header advert
Orthopaedic Proceedings Logo

Receive monthly Table of Contents alerts from Orthopaedic Proceedings

Comprehensive article alerts can be set up and managed through your account settings

View my account settings

Visit Orthopaedic Proceedings at:

Loading...

Loading...

Volume 92-B, Issue SUPP_III July 2010

S Pilankar N Harshavardhana N Patil V Bagaria A Karkhanis

Purpose: To eliminate iatrogenic Ulnar Nerve injury.

Methods: We prospectively reviewed 25 consecutive paediatric gartland’s type 3 supracondylar fractures with a minimum follow-up of 1 yr operated by our novel technique. Good reduction was achieved with closed reduction in 20 and 5 cases warranted an open reduction. Our technique involved passage of two percutaneous 1.6 mm smooth K-wires supero-medially from lateral condyle across the fracture site to obtain a purchase in upper medial cortex of proximal fragment. A third K-wire was passed percutaneously from lateral supracondylar pillar proximal to the fracture site in infero-medial direction to gain purchase in distal fragment’s subchondral bone of medial condyle thus creating a cross construct. Care was taken not to breach the subchondral bone so as to avoid ulnar nerve injury. All patients were operated in supine position under general anaesthesia and lateral collateral approach was used with same K-wire construct in cases that needed open reduction. Stability was checked post-operatively by rotation under real time imaging. The mean age of patients was 6.8 yrs. The mean time from sustaining the fracture to operative pinning was 24 hrs. An above elbow immobilisation backslab was applied for 3 weeks. The K-wires were removed at 3 and 4 weeks in cases that had closed and open reduction respectively and active assisted movements were initiated. All patients were followed up at 1/52, 3/52, 6/52, 3/12, 6/12 and 1 year post-operatively.

Results: Flynn’s criterion was used for post-op functional evaluation. 20 cases had excellent and 5 had good outcome at end of 1 year. There was no case of nerve palsy (superficial radian or ulnar N), pin-tract infection, loss of reduction or late cubitus varus/valgus or hyper-extension deformities.

Conclusion: Our innovative technique is an excellent alternative option without compromising on fracture stability in the treatment of these fractures.


D M Lang P Monga

Aim: To review the outcomes for avulsion fractures of the tibial spine in children managed by arthroscopic internal fixation using a canulated screw.

Materials & Methods: A retrospective review was performed of 8 tibial spine avulsion fractures in children managed operatively by arthroscopic canulated screw fixation over a 4 year period. All fractures were graded grade III or IV (Meyer and McKeevers) in severity. Notes and radiographs were reviewed and Lysholm scores were obtained. The average age of our patients was 10.6 years and the average duration of follow up was 23.6 months (Range: 3–52 months). The average Lysholm score achieved was 88.9 (median 94.5, range 61–100) with the score demonstrably improving after the first year from injury. Bony healing was seen in all cases. One patient needed manipulation under anaesthesia to realize full movement.

Conclusions: On the basis of these results, we recommend arthroscopic canulated screw fixation as the treatment of choice for tibial spine avulsions. It takes over a year, however, to achieve optimal results. This series represents the largest collection of these uncommon injuries hitherto reported from the UK.


L M O’Connor-Read J The K Willett

Spiral fractures are one of the most common fractures seen in non-accidental injury. In such cases, with radiographic evidence for the mechanism of injury, the physician is more capable of identifying any inconsistencies in the offered explanatory history.

The objectives of the study were to detail and differentiate the fracture patterns created by rotation forces in different directions and to determine the reliability of that recognition method applied to standard radiographs.

Twenty rabbit femurs were fractured using a torque transducer and imaged using standard anterior-posterior and lateral radiographs. The radiographic interpretation skills of paediatric, radiology, orthopaedic and emergency room doctors were assessed before and after being given the findings of this study.

The radiographic propagation of the spiral fractures was consistent and followed six simple principles. There was a statistically significant difference in the numbers of correctly diagnosed radiographs, before and after the explanation of our findings, by these doctors (chi-squared=14.06, df=1, p=0.002).

The direction of the torsional force producing spiral fractures can be determined from characteristic features on routine radiographs but does not seem to be intuitive. These derived six principles will be a useful aid to physicians who manage paediatric spiral fractures where non-accidental injury is being considered.


T N Theologis S Matthews CLMH Gibbons G Kambouroglou

The purpose of the study was to establish an algorithm for the treatment of pathological fractures in children.

Pathological fractures can compromise radiographic and histological diagnosis. The need for histological diagnosis and indications for surgical treatment are not clearly defined.

We reviewed our Centre’s Tumour Registry records of children who presented over the past 7 years with a fracture as the first manifestation of primary bone pathology. There were 23 patients (average age 12 years and 2 months).

There were 9 fractures through simple bone cysts, all treated conservatively initially. All patients were subsequently treated with needle biopsy and bone marrow injection. Three patients suffered refracture and underwent flexible intramedullary nail fixation.

There were 5 cases of fibrous dysplasia. Histological diagnosis was obtained in all cases, followed by prophylactic intramedullary nailing in 3 patients.

There were 2 patients with giant cell tumour, 3 with aneurysmal bone cyst and one with chondroblastoma. Histological diagnosis preceded curettage and grafting in all cases.

Finally, there were 3 patients with Ewing’s sarcoma of the femur. One underwent palliative intramedullary nailing for extensive local disease. The second patient was treated conservatively initially. She subsequently underwent segmental resection and vascularised fibular graft. The third patient underwent internal fixation in another unit for what was considered to be a benign lesion. The histological diagnosis of Ewing’s sarcoma was based on intra-operative specimens. Definitive surgery required wide resection and prosthetic replacement.

We recommend that primary fixation of pathological fractures should be avoided until histological diagnosis is obtained. All lesions should be appropriately imaged and biopsied if aggressive characteristics are present. However, if radiographic appearances are reassuringly benign, biopsy can be delayed until conservative fracture management is completed. Definitive treatment of benign lesions with protective intramedullary nailing or curettage and grafting can follow frozen section under the same anaesthetic.


P A Templeton DJC Burton E Cullen H Lewis V Allgar R Wilson

Purpose: To determine if oral midazolam reduces the anxiety of children undergoing removal of percutaneous Kirschner wires (K-wires) from the distal humerus in the Orthopaedic Outpatient Department.

Methods: This was a prospective double blind, randomised controlled trial. 46 children aged between 3 and 12 years who had supracondylar fractures of the distal humerus internally fixed with K-wires were randomised into 2 groups. 0.2mg/kg oral midazolam (active group) or the same volume of an oral placebo (control group) was administered 30 minutes prior to removal of K-wires.

Venham Situational Anxiety Score was performed before and immediately after removal of K-wires. University College London Hospital sedation score was recorded every 20 minutes.

Results: 42 children with an average age of 7.1 years (range 3.6–12.3 years) had complete documentation for analysis. The two groups had similar demographics. All wires were removed in the clinic with or without midazolam.

There was no significant difference in anxiety scores between the groups either before or after wire removal. The change in scores was not significantly different between the 2 groups. However, 45% of children in the active group had reduced anxiety levels in the active group compared to 18% of children given placebo but this difference was not significant (p=0.102). No child was excessively sedated but one in the active group became agitated and restless.

Conclusions: The anxiety scores before and after wire removal in the active group were not significantly different from the placebo group scores. We do not recommend the routine administration of midazolam (0.2 mg/kg) to all children requiring k-wire removal in the outpatient department.


D Jackson E Main M Mayston D M Eastwood

Purpose: In neuromuscular conditions, ankle foot orthoses (AFO) prevent deformity and improve functional balance by increasing the base of support, stabilizing the ankle joint and influencing the kinematics of more proximal joints; this study was designed to evaluate the role of fixed AFOs on balance in spastic diplegic children.

Methods: 12 children (age 7–15yrs) with spastic diplegia were recruited. All were community ambulators (GMFCS II/III). All had used AFOs for 12 months. Each child walked along the GAITRite electronic walkway at their preferred speed: barefoot, in shoes, and in AFOs with shoes. The order of the walks was randomized limiting the effects of fatigue and confidence. Normalized velocity, cadence, stride length and percentage of gait cycle in single leg support were selected as surrogate measures of stability. The child’s balance during other functional activities was assessed with the paediatric balance scale (PBS).

A two-way analysis of variance (ANOVA) explored differences in gait between the various walks. Fried-man’s test tested for differences in PBS scores between subjects and conditions.

Results: Significant improvements were seen in mean values for normalized velocity (p=0.02), stride length (p< 0.01) and percentage of gait cycle in single leg support (p< 0.01) in footwear-AFO compared to barefoot. Whilst there were also improvements in mean values for these parameters in shoes alone compared to barefoot, only the difference in stride length reached statistical significance (p< 0.01). There were no significant differences in PBS scores in shoes alone or with AFOs compared with walking barefoot.

Conclusions: AFOs improved balance during gait but had no effect on balance during other activities. Whilst shoes alone had a positive impact on gait, the most significant effects were seen in the AFO-footwear combination.

Significance: Advice regarding AFO use and footwear choice should consider the effects on gait as well as prevention of deformity.


DP Williams A Carriero A Zavatsky T Theologis J Stebbins SJ Shefelbine

Purpose: The aim of this research was to characterize the correlation of magnetic resonance image (MRI) measurements of femoral anteversion and tibial torsion with transverse plane kinematics from the gait analysis of ten healthy and nine cerebral palsy (CP) children.

Methods: The bone morphologies of nine spastic diplegic CP and ten healthy children were obtained by analysis of 3D MRIs. Location of anatomical landmarks along the femur and tibia were detected using medical imaging software. Each point was then defined with respect to bone-embedded femoral and tibial Cartesian coordinates, allowing 3D reorientation of the bone independent of the patient position within the scanner. Femoral anteversion was defined as the angle between the femoral neck and the transcondylar plane. Tibial torsion was defined as the angle between the transcondylar axis of the proximal tibia and the bi-malleolar axis.

Three-dimensional motion of the lower limbs was measured using gait analysis. Transverse plane kinematics, including hip rotation and foot progression angles were recorded.

Results: A moderate correlation was found between femoral anteversion, and maximum and average hip rotation in CP children (0.64 and 0.65). A high correlation was also seen between tibial torsion and maximum and average values of hip rotation for CP children (0.71 and 0.74). In healthy children, the only correlation observed was between femoral anteversion and average foot progression in stance (0.75).

Discussion: In healthy children, femoral anteversion appears to influence foot progression angle, implying that this can lead to an internally rotated gait. In CP children, the correlation between femoral anteversion and hip rotation is only moderate. The interaction between different joints is more complex and the rotation of joints is determined by multiple factors. This study showed that tibial torsion also plays a role in determining hip rotation during gait.


S Masud S Ansara S S Geeranavar

Aim: To assess the risk of iatrogenic ulnar nerve injury using the mini medial incision to reduce and stabilise displaced supracondylar fractures of the humerus in children with crossed K-wires.

Methods: We performed a retrospective evaluation of 26 children with closed Wilkins type IIB and III supracondylar fractures of the humerus, without vascular deficit, between January 1999 and April 2007. Mean age was 5.5 years (2.5–11 years). All were treated with open reduction and crossed K-wire fixation using a mini medial incision (5cm). Our modification is that we do not expose the fracture site or the ulnar nerve. It is a “feel” rather than “see” approach. The medial K-wire is placed under direct vision. All patients had early and late (4 months) post-operative ulnar nerve assessment. Patient outcome was assessed clinically using Flynn’s classification and radiologically using the metaphyseal-diaphyseal and humerocapitellar angles. Mean length of follow-up was 5 months (4–8 months).

Results: There was no post-operative ulnar nerve injury. Clinically and radiologically there were 23 excellent and 3 good results.

Conclusions: The mini medial incision is simple. It provides an excellent view for correct medial pin entry; hence it reduces the risk of iatrogenic ulnar nerve injury. Crossed K-wires provide a stable and reliable fixation.


C Blakey L Biant R Birch

Purpose: To investigate the mode of presentation, management and outcome of ischaemic contracture following a supracondylar fracture with a pink, pulseless hand.

Methods: We reviewed the database at our tertiary referral unit to identify cases over a 20 year period who had been referred for complications of a supracondylar fracture and/or a Volkmann’s ischaemic contracture.

Results: We identified 20 children with Volkmann’s ischaemic contracture following a supracondylar fracture. Of these, 4 patients (mean age 5, range 2–11) were referred to us with evidence of an ischaemic contracture but they had always had a pink albeit pulseless hand. Two of these 4 had undergone vascular exploration at 48 hours and at 72 hours but despite this developed an ischaemic contracture.

The 2 patients with the most severe contractures have undergone surgical intervention for their contracture, and 2 were managed conservatively with splinting. All 4 cases have residual problems with hand function (mean follow-up 5.5 years, range 2–11).

Conclusions: Volkmann’s ischaemic contracture should be a preventable condition. The pink albeit pulseless hand is at increased risk of ischaemic muscle and nerve damage and should not be ignored as the consequences are potentially devastating.

Significance: Clinicians must consider whether they feel that their management protocols for the pink, pulseless hand are robust and defensible.


Y V. Joshi V K. Peter A Bass

Purpose: Some patients with Cerebral Palsy who had a de-rotation osteotomy performed for correction of excessive anteversion had persistence of internal foot progression even after the surgery. The aim of this study was to see if there is any relationship between significant abductor weakness [less than Grade III: MRC] and persistence of internal foot progression.

Methods: We included all ambulatory patients with cerebral palsy who had had a de-rotation osteotomy between the periods of 2000 – 2005, who had also had a pre and post operative gait analysis, assessment of ante-version, muscle charting and hip range of movements.

There were 12 patients [17 hips, 5 bilateral] 5 male 7 female with an average age of 13. Seven were diplegic, two hemiplegic and three had asymmetric diplegia. Data was assessed using SPSS 13.0. As the data was found to be normally distributed the Fisher exact test and the Spearman’s Co-relation Coefficient was used.

Results: Of the 17 limbs operated, preoperative femoral anteversion was 20–60 degrees [mean: 45] and post op femoral anteversion was 0–35[mean: 15]. Of these 7 hips had persistent internal rotation gait on gait analysis. None of these patients with persistent internal rotation had any hip capsular contractures, and there was no significant change in abductor power after surgery.

On testing the hypothesis it was found that there is no relationship between weak hip abductors and persistent internal rotation. [Fisher exact test: p value: 0.8, r = -0.07]

Conclusion: Weak abductors may not be a cause of persistent internal rotation following de-rotation osteotomy. Weak abductor power is not a contraindication to de-rotation osteotomies and do not affect outcome of surgery.


GH Prosser PR Glithero JN O’Hara

The purpose of the study was to assess the usefulness of this combination of operations in this challenging patient group.

18 patients (19 hips) with cerebral palsy and painful subluxed or dislocated hips underwent hip resurfacing with shortening and rotation osteotomy of the femur between 1999 and 2005. The mean age was 25 (range 14–59) and follow-up averaged 47 months. Eleven patients were quadriplegic, five were diplegic and two were hemiplegic.

There were no infections. There were two plate cut-outs and two dislocations. All stabilised following necessary treatment. Four plates were removed after about one year. All quadriplegic and four of the diplegic patients were chair-bound pre-operatively. Their carers all felt that their comfort sitting had improved. Seventeen patients (eighteen hips) were pain-free at latest follow-up. One patient, whose plate had not been removed had some lateral tenderness on transferring, but no apparent pain on sitting. Three of the previously chairbound diplegic patients were able to stand and one was able to walk.

As all eighteen of the carers were very satisfied with the outcome, this approach to the treatment of these challenging patients has proved promising


P Torres R Taranu J Quinby

The aims of this study were to compare the outcome of epiphysiodesis in patients with limb length discrepancy (LLD) as a result of cerebral palsy with those as a result of other causes in order to test our hypothesis that the hemiplegic / monoplegic limb may respond differently to epiphysiodesis, to evaluate the accuracy of the Moseley method and evaluate whether there is any difference between the outcomes of left or right hemiplegic limbs with LLD bearing in mind that the left hand is used for bone age calculations.

We reviewed the case notes and radiographs of 34 children who had undergone epiphysiodesis for the management of LLD by the same surgeon, using the Moseley method between February 1999 and May 2005 to final follow up at skeletal maturity. Of the 34 patients, 9 had a LLD as a result of cerebral palsy (4-Left, 5-Right) and 25 as a result of other causes. In the cerebral palsy group the mean residual LLD was 0.59cm and in the other group it was 1.18cm. Both groups were similar in terms of age and sex distribution. There was no demonstrable statistically significant difference in outcome between the 2 groups (unpaired T test, P=0.734). The Moseley method appeared accurate and there was no difference demonstrated in the outcome between left and right hemiplegic LLD.

We conclude that the Moseley method is reliable. We have not found any evidence that the hemiplegic limb behaves any differently. We have not demonstrated any difference in the outcome of left or right hemiplegic limbs.


R Kanwar K Johnson H Prem

Aim: Assess healing pattern of Achilles tendons across gap created by percutaneous tenotomy and maintained by cast in club feet.

Methods and Results: 21 tenotomies in 16 patients (Age range 12 weeks–36 months) were monitored with dynamic and static ultrasonographic studies. Ultrasounds performed before, immediately after and at approximately 3, 6, 12 weeks post tenotomy. Cast removal was done at 3 weeks. Two patients above age of two were casted for 6 weeks.

The healing pattern went through different phases although they were not distinctively exclusive from each other and did show considerable overlap. First phase showed formation of bulbous mass with some continuity of scar tissue across tendon gap. The transition zone between new fibre and the original tend quite distinct. However dynamic ultrasound showed the Achilles tendon moved as a single unit. Second phase showed fibres resembling normal tendon crossing the gap and reduction of bulbous mass. The transition zone was still discernible. Final stage demonstrated more homogenous fibres of Achilles tendon with an indistinct transition zone. Two older children showed a distinctly longer process of healing.

At 3 weeks there was no evidence of healing.

At 6 weeks an irregular mass of fluid and soft tissue structures was seen.

At 12 weeks there was evidence of continuation of tendon fibres, but transition zone partly visible.

Conclusion: Young Child (< 1 Year): When cast immobilisation is discontinued, the tendon is in mid phase of healing. There may be a positive effect on continued improvement in dorsiflexion while using boots and bars.

Older Child-Safe to consider percutaneous tenotomy in children up to 3 years of ages provided the period of immobilisation is extended.


SA Clint O Malaga-Shaw B Rudge MJ Oddy M Barry

Although Bohler’s & Gissane’s angles are measured in adult calcaneal fractures, it is not known if such measurements are reliable in children nor how such measurements vary with the age of the child.

The Picture Archiving and Communications System (PACS) databases of 2 London Teaching Hospitals were searched and all children who had a lateral ankle xray taken as part of their attendance to the A& E department were identified. Films were excluded if there was a fracture of the calcaneus or if the film was oblique or of poor quality. Bohler’s and Gissane’s angles were measured using the image viewer software. All patients’ films were measured on two separate occasions and by two separate authors to allow calculation of inter- and intra-observer variation. Interclass Correlation Coefficients (ICC) were used to assess the reliability of the measurements.

347 children were identified and after exclusions, 218 films were used for the study. The overall ICC for Bohler’s angle inter-obsever error was 0.91 and for intra-observer error was 0.92, giving excellent correlation. This reliability was maintained across the age groups. Gissane’s angle inter-observer error was very poor and the intra-observer error poor across the age groups, although accuracy did improve as the patients approached maturity.

Further analysis of the Bohler’s angle showed a significant variation in the mean angle with age. Contrary to published opinion, the angle is not uniformly lower than that of adults but varies with age, peaking towards the end of the first decade before attaining adult values.

We feel that measurement of Gissane’s angle is unreliable in children but measurement of Bohler’s angle is accurate and reproducible. Bohler’s angle varies with age and knowledge of Bohler’s angle variation is important in the evaluation of os calcis fractures in children.


A Khurana S Kadambande V Goel A Ahuja D Baker KJ Tayton

Introduction: Physical challenges and a long term treatment for Perthes disease can affect patients’ behaviour in their adolescence. We carried out a study to assess the long term psychosocial development of children treated non-operatively using abduction cast and brace.

Methodology: 104 patients treated for Perthes disease between 1992 and 2001 were recruited for a retrospective study. Besides clinical review, patients and their main carers were asked to fill in Strengths and Difficulties Questionnaires (SDQ). SDQ included scores for total difficulties, emotional symptoms, conduct problems, hyperactivity, peer problems, social behaviour and total impact. 70 controls, matched for age and sex, attending the clinics for other unrelated pathology were requested to fill in the same questionnaires along with their main carers.

Results: Data from 91 patients was available for assessment. Age at diagnosis was 1.9 to 7.3 years (median 3.9 years). Follow-up duration was 5.6 to 15.1 years (median 8.7 years). The age of subjects at final follow up was 8.9 to 20.4 years (median 15.3 years). The mean duration of treatment in abduction cast or brace was 2.4 years.

57 controls and 69 subjects were found to be low risk for emotional disorder (p> 0.05).

Similarly 58 control and 74 subjects were predicted to be low risk for behavioural disorder. 16 controls and 18 subjects had medium or high risk for hyperactivity or concentration disorder (p> 0.05; student t test). There was no significant difference between the self report and parent questionnaires for difficulties or their impact.

Conclusion: Perthes disease and the resultant restricted physical activities in early childhood does not affect the emotional and mental well being of patients in a long term.


R Kanwar C Lever CE Bache

Aim: To audit the impact of emergency hip ultrasound in the management of suspected hip septic arthritis.

Methods and Results: Case series – Review of 13 consecutive patients who presented with acute hip pain, where clinical examination and inflammatory markers, highly suspicious of Septic arthritis.

Emergency ultrasound was only available in 9 patients.

Only 5 (38%) of these 13 patients had septic arthritis.

Septic arthritis group.

– Emergency ultrasound unavailable in 2 patents. They proceeded straight to arthrotomy yielding pus.

– 3 had a preoperative ultrasound which confirmed the hip joint had an effusion.

“Non Septic Arthritis of Hip” (8 patients).

– In 2 patients emergency ultrasound unavailable. They underwent emergency arthrotomy with negative findings of pus.

– 1 actually had septic arthritis of knee.

– 6 patients did have emergency ultrasound which showed no effusion. Emergency arthrotomy was cancelled.

– They proceeded to MRI of Hip. MRI revealed pathology close to but not involving the hip:

Pelvic osteomyelitis,

Psoas abscess,

Gluteal abscess secondary to small bowel fistula

Cellulitis of medial thigh

Femoral Epiphysis osteomyelitis

and inflammation of tendon secondary to line insertion.

Inflammation of rectus femoris tendon (secondary to central line insertion). Conclusion: Use of ultrasound avoided unnecessary arthrotomy in 6 patients (48%).

If ultrasound was available in all cases, then 8 (63%) patients would have avoided an unnecessary arthrotomy.

Out of hours urgent hip ultrasound may be difficult to request. However our recent experience leads us to propose that if available ultrasound should be performed in all suspected case of hip septic arthritis prior to surgical drainage.

Pathology in the vicinity of the hip can often masquerade convincingly as a septic hip joint.


MK Osman DJ Martin DA Sherlock

Aim: To assess the outcome for Perthes disease in children over eight treated by observation, varus osteotomy, abduction plasters and acetabular augmentation.

Methods and results: A retrospective case note review of prospectively collected data for 44 children (48) hips with Catterall grades 2, 3 or 4 Perthes’ disease with onset age eight or older and followed to maturity was performed. The groups were demographically similar. For all groups combined 60% had a satisfactory Stulberg grade I to III outcome. Poorer outcomes (as assessed by Stulberg, centre edge angle and Reimer’s migration index) were associated with increasing age, greater initial head deformity and greater head involvement. Initial head deformity did not remodel for any treatment group. Indeed, progressive head deformity occurred despite plaster treatment or varus osteotomy but not after acetabular augmentation. Hips managed by acetabular augmentation also had better outcomes than the other groups for Stulberg, Reimer’s index and centre-edge angle.

Conclusions: Whatever the treatment the outcome for Perthes’ disease in children over eight is poorer with increasing age. No treatment offers the prospect of a good result in the older child with significant head involvement or significant initial deformity but acetabular augmentation seems to improve Stulberg, Reimer’s migration and centre-edge angle outcomes and prevents progressive femoral head deformity compared with observation, varus osteotomy and plaster treatment.


PD Mitchell R Redfern

The aim of the study is to highlight the skeletal changes that result from untreated DDH if it is decided to leave the hip unreduced, as may occur if a child presents at a late age. This is of interest today as the data with which we try to determine prognosis in such cases is very old and comprised of small patients numbers. The method used is the study of c.10,000 human skeletons excavated from the medieval cemetery of Spitalfields in London, dating from 1100–1530AD. Diagnosis was made by the presence of an abnormal true acetabulum incompatible with articulation with a femoral head in life, with an associated false acetabulum on the iliac wing. The results demonstrated a range of skeletal consequences in the 13 dislocated hips present. At the hip joint itself, degenerative change was only present in cases with a well developed, cup-shaped false acetabulum. Only 17% of cases had such a cup-shaped false acetabulum. Cases with no such false acetabular cup (83%), presumably with soft tissue articulation, showed no degenerative change. Hip adduction with valgus knee was common, as was femoral neck anteversion with compensatory tibial torsion. Scoliosis in unilateral cases caused lateral wedging of vertebral bodies and markedly asymmetric degenerative change in older individuals. We conclude that the presence or absence of a deep cup-shaped bony acetabulum at late presentation may have prognostic implications as to whether degenerative change in the hip, and so pain, may occur in adulthood. If confirmed by clinical studies, this may influence whether an attempt at reduction should be made. From the viewpoint of the spine, if a hip is reduced late, surgeons should be aware that the scoliosis may not correct as they would expect if the vertebrae are already laterally wedged by the time the child presents.


H L George Y Joshi L E James D Shivrathri C E Bruce

Purpose: Scarf osteotomies are commonly performed in adults with symptomatic bunions. We have reported the radiological and clinical outcome of this procedure in the treatment of moderate to severe hallux valgus among adolescent children.

Methods: Data was collected retrospectively from a tertiary referral children hospital between April 2001 and June 2006. The pre and postoperative intermetatarsal angle (IMA), hallux valgus angle (HVA) and distal metatarsal articular angle (DMAA) were determined. Patients were followed up for a mean of 8.6 months (3–18).

Results: 23 scarf osteotomies were performed in 16 patients with a mean age of 14.3 years (12–18). The mean pre operative IMA of 14.4 degrees was improved to a postoperative value of 9.3 degrees, p< 0.0001. The mean HVA angle was improved from 34.7 to 16.5 degrees, p< 0.0001. The DMAA was improved from 13.1 to 8 degrees, p< 0.0001. There were 2 cases of superficial wound infections successfully treated with oral antibiotics. One patient developed a complex regional pain syndrome that resolved with physiotherapy and analgesia.

Conclusion: We believe that scarf osteotomy is a safe and effective option for the management of the adolescent symptomatic bunions.

Significance: There are no published reports in the English literature of scarf osteotomy in the management of adolescent children with symptomatic hallux valgus. The aim of this paper is to report the radiological and clinical outcome of scarf osteotomy in the treatment of moderate to severe hallux valgus among adolescent children.


Full Access
E Bache

Introduction: Approximately 5% of grade III supracon-dylar fractures are associated with vascular compromise. Following closed reduction and K wire stabilisation 60% of childrens surgeons in UK would adopt a policy of observation providing the hand is well perfused. We have retrospectively compared 2 groups of patients to determine whether observation or exploration leads to the best outcome.

Materials and Methods: Over a 7 year period 18 patients were identified with pulseless pink hands. Management following reduction and K wire fixation was at the discretion of the admitting consultant. 10 Patients were managed expectantly and 8 patients had immediate exploration of the vessel.

Results: Of 10 patients managed by observation, 3 had secondary exploration of the vessel and one patient has developed forearm claudication. Although a palpable radial pulse was present in all cases by 3 months it had returned within 24hrs (suggesting spasm of the artery) in only 3 patients.

In 6 of 8 primarily explored brachial arteries the vessel was observed to be tethered to the fracture site.

Following release, in 6 of 8 cases the radial pulse had returned within 24hrs. Satisfactory radiological reduction of the fracture does not preclude vessel entrapment.

In 8 cases there was an associated median nerve palsy. All of these cases were found to have an anatomical obstruction to the brachial artery.

Conclusions: In the majority of cases absent pulse is due to vessel entrapment. Long term perfusion of the forearm is due to collateral circulation. Providing a near anatomical reduction is achieved observation for 24 hours would seem reasonable course of action. If the pulse has not then returned further imaging (arte-riograme/MRA) may be advisable. If there is associated nerve palsy immediate exploration is warranted


Y Chee KH Teoh N Shortt D Porter

Introduction: We conducted a prospective study on 29 patients comparing the medium-term outcome between intramedullary nail fixation and plate fixation in paediatric forearm fractures.

Materials and Methods: The criteria were patients who had a nail (10) or plate fixation (19) for a single or both bones forearm fracture between 2004 and 2006. All these patients were recalled following ethical approval for assessment of their grip strength using a hand dynamometer, forearm and elbow range of movements, scar assessment, POSNA outcome questionnaire and new radiographic views of the forearms.

Results: Mean age of 10.4 years for both groups (4–16), All fractures were caused by low velocity falls. Grip strength is reduced in 83% of patients, comparable in both groups. Elbow flexion is more reduced in the plating group but more reduction in extension in the nailing group. The reduction in forearm pronation (69% of patients) and supination (61%) were comparable in both groups. Using the ‘Manchester scar proforma’; the plating group scored worse with 14/21; nail 11/21. ‘POSNA outcome questionnaire’ score showed the nailing group had 90% excellent or good result and plating group 74%. The moderate and poor POSNA outcome (26% plate, 10% nail) were associated with pain, restricted rotation, bad scarring and difficulty lifting heavy objects. Nails were removed after bony healing but all plates were left in situ. Complete remodeling of forearm bones were seen in all radiographs in both groups. One case of non-iatrogenic ulnar nerve injury and two cases of wound infection were noted; all made full recovery.

Conclusion: The medium-term outcome at 2.5 years following either fixation method is generally comparable and good. The obvious differences were; a higher (better) POSNA score in the nailing group, larger scar formation in plating, elbow extension restriction in nailing and elbow flexion restriction in plating group. Factors that were comparable were grip strength, forearm rotation and radiographic remodeling and outcome.


J Bell S Dass S Viswanathan G Donald

Introduction: Forearm fractures are the most common long bone fracture in the paediatric population. Associated neurological injury is a well recognized complication of these injuries yet is generally considered to beuncommon. This study sought to evaluate the incidence of neurological impairment in children referred for manipulation by the orthopaedics team in this tertiary referral hospital.

Materials & Methods: A retrospective chart analysis was performed of the first 100 children to be referred for orthopaedic assessment. This represented 43% of the total number of children presenting to the emergency department in this time period. Inclusion criteria involved a fracture of any segment of the radius and/or ulna on radiological examination. Exclusion criteria included concomitant ipsilateral upper limb fracture, and compartment syndrome.

Results: A total of 96 cases met the inclusion criteria. The cohort had a mean age of 8.04. Males were more likely to be injured as was the left forearm. The distal metaphysis was the segment most likely to be fractured and compound injuries were uncommon. The incidence of associated neurological impairment was 15.6%. The median nerve was most commonly injured, comprising 60% of nerve injuries. Distal physeal fractures were the most common fracture pattern to be associated with neurological impairment, with a rate of 37%.

Conclusions: Forearm fractures requiring manipulation in the paediatric population are commonly associated with nerve injuries, with distal physeal fractures having a particularly strong correlation. Clinicians require a high index of suspicion for nerve injury when evaluating forearm fractures to avoid underdiagnosis. Failure to recognize neurological injury at the time of initial assessment has the potential to delay time to reduction due to the injury being misclassified as non-urgent. This delay has the potential to cause a prolonged or failed recovery of nerve function.


B Kowalczyk T Lejman

Background: Pediatric comminuted femoral shaft fractures are not frequent but difficult in treatment due to concomitant injuries and instability. Although orthopaedic literature is rich in reports on paediatric femoral shaft fractures only few focus on comminuted ones.

Purpose: The aim of the study is to present results and complications of surgical treatment in comminuted femoral shaft fractures during growing age.

Material and Methods: Between 2001–2006 twenty eight children presented with 29 wedge or complex femoral shaft fractures. All children underwent clinical and radiographic examination on follow up and their medical data was retrospectively reviewed. TEN scoring criteria, time to solid union, early and late complications were of the primary interest during follow up assessment.

Results: There were 18 boys (64,3%) and 10 (35,7%) girls. Their mean age during injury was 10,1 years and average follow up period was 35,7 months. In 15 children (53,6%) multiple injuries were present. Three fractures were treated conservatively, the remaining 26 underwent closed or open reduction with stabilization using EBI external fixation, intramedullary Rush or TEN rodding, multiple screws or plate osteosynthesis.

On follow up there were 12 (41,4%) excellent, 14 satisfactory (48,2%), 3 poor (10,4%) results. All fractures united and a mean time to achieve solid union was 20,7 weeks. Leg length discrepancy occurred in 20 children (71,4%), and in 10 (35,7%) was greater than 10 mm. Four children required in early secondary surgical procedures to achieve better alignment or fracture stabilization. One femoral osteomyelitis required in surgical drainage and prolonged intravenous antibiotic therapy.

Conclusions: Comminuted femoral shaft fractures in children heal well after surgical treatment although the risk of serious complications is high. Intramedullary rodding seems to be sufficient in most cases. Screw fixation alone should be avoided.


K K Stöhr M Dobson A Roposch

Purpose: To determine the effect of the ossific nucleus on avascular necrosis (AVN) of the hip in the treatment of hip dislocation.

Methods: A systematic review was performed in MED-LINE, EMBASE, DARE, and Cochrane Library. Two independent reviewers evaluated all articles. Interrater agreement was determined by the kappa statistic. Quality of evidence was evaluated by the GRADE statement. A meta-analysis was performed on the main outcome, AVN 2 years after reduction.

Results: 6 observational studies met the inclusion criteria. Inconsistency was found in that half of the studies reported a protective effect of the ossific nucleus, whereas half of the studies did not. A meta-analysis of all studies (415 patients) showed no statistical significant effect of the ossific nucleus on the development of AVN, with 42 (17%) cases of AVN in infants with the ossific nucleus present at reduction compared with 47 (28%) in the group without a ossific nucleus (RR 0.60, 95% CI 0.28 to 1.27). If only radiographic changes of grade ≥II were considered AVN, a significant difference in the prevalence of AVN was found, with 15 (6%) cases of AVN in infants with the ossific nucleus compared with 28 (20%) without the ossific nucleus (0.34, 0.17 to 0.67). Subgroup analysis showed that the presence of the ossific nucleus reduced the probability of AVN by 70% (0.30, 0.14 to 0.62) in case of a closed reduction, but no significant effect was found for open reduction (0.87, 0.50 to 1.54). All studies demonstrated methodological weaknesses compromising the quality of evidence.

Conclusion: We could not demonstrate a significant effect of the ossific nucleus on the development of AVN. The meta-analysis suggested that the ossific nucleus might have a protective effect against the development of more severe forms of AVN.


J D Annan R B Abu-Rajab D Young G C Bennet

Introduction: Growing pains are a common complaint in school age children, but no definite organic causes have been identified. An association between musculoskeletal pain and joint laxity has been proposed. This study therefore investigates the relationship between growing pains and joint hypermobility in children.

Materials and Methods: Thirty three children with growing pains and thirty one controls of similar age and sex were recruited from outpatient clinics of a specialist paediatric hospital. Joint hypermobility was assessed in each group using the Beighton score. A Beighton score of greater than or equal to 4 out of 9 was considered hypermobile.

Results: The median Beighton scores were 6 for the study group and 0 for the control group. 93.3% of the study group had a Beighton score of equal to or greater than 4, compared to 22.6% of the control group. There was a highly significant difference in Beighton score between the two groups (P< 0.0001), with an estimated difference of 4 points 95% CI 4–6.

Discussion and Conclusion: A link between joint hyper-mobility and musculoskeletal symptoms has been demonstrated in adults. There is also some evidence that hypermobile children are more likely to experience musculoskeletal pain, particularly articular, but the extent to which joint hypermobility is related to growing pains specifically has been poorly defined. We have investigated a selective population of children with growing pains and have shown them to be significantly more hypermobile than the control children. The aetiology of growing pains remains unclear. While the growing pains will get better, in view of the possible association of joint hypermobility and other musculoskeletal complains, these children should be carefully assessed for joint laxity.


A S Bajwa RJ Montgomery

Background: Aim of the study was to evaluate the clinical results of Montgomery Hip Screw for fixation of proximal femoral osteotomies. There are a number of devices for proximal femoral fixation, including sliding hip screws. Rotational instability of the proximal femoral segment can be a problem. To overcome this, a hip screw has been introduced with two screws in the proximal segment.

Methods and Results: A prospective cohort undergoing osteotomy was followed up. Inclusion criteria included consecutive patients < 16 years of age, with an indication for elective proximal femoral osteotomy. All operations were performed by senior author or under his supervision using a standard postero-lateral approach. Further incisions for adductor/psoas release and pelvic osteotomy were added as indicated. In 23 cases MHS was used with a mean follow up of 10 months (6 to 24). In 9 patients there was an underlying neurological problem, one case of LCPD, and the rest had DDH. Previous surgery with a hip screw on the contralateral side had been undertaken in 5 cases. The mean age was 5 years (range 1 to 12) and mean time to union was 6.3 weeks. There were no occurrences of rotational instability or failure of fixation. No wound complication was encountered in the cohort.

Conclusions: Early results indicate that Montgomery Hip Screw is a safe device for fixation of proximal femoral osteotomy with the added advantage of rotational stability.


J. Barnes S. Thomas J. Wedge

Introduction: A criticism of innominate osteotomy is that it causes relative acetabular retroversion, predisposing to osteoarthritis. This study was designed to address this hypothesis.

Materials and Methods: We had access to radiographs of 30 patients that had undergone open reduction and innominate osteotomy for late presenting developmental hip dislocation. The patients are now middle-aged and formed part of a previously reported study on the long term outcome of this protocol. Standardised, well-centered anteroposterior standing hip radiographs had been obtained. We used the validated method of Hefti (1995) to measure anterior and posterior acetabular coverage and contact area. All measurements were made by a single independent investigator.

Results: 10 operated hips had advanced osteoarthritis which made it impossible to identify acetabular landmarks. 26 hips were readable despite signs of mild to moderate osteoarthritis in some (Group A). 20 contra-lateral hips without DDH which appeared radiographically normal formed control group B.

Discussion: We were unable to assess operated hips which had gone on to replacement or severe osteoarthritis. This is a flaw as those hips with better radiographs have been selected out for study. Nonetheless this was a unique opportunity to assess the effect of innominate osteotomy on acetabular development in good numbers of hips with a variety of evolved outcomes.

Conclusion: Acetabular coverage and load area in hips with a good outcome after innominate osteotomy with open reduction were not different to a control group of radiographically normal hips without previous DDH. Innominate osteotomy before the age of 5 years has the potential to facilitate, or at least not prevent, normal acetabular development and version.


S Thomas J McCahill J Stebbins C Bradish M McNally T Theologis

Introduction: Fibular hemimelia (FH) is a congenital limb reduction deficiency characterised by partial or complete absence of the fibula and a spectrum of associated anomalies. For children with a major anticipated limb length discrepancy and severe foot deformity, management (amputation or limb reconstruction) is controversial.

Materials and Methods: 8 children who are now adults (average age 28 years) underwent limb reconstruction as children in one of two UK centres for severe fibular hemimelia. All 8 participants were recalled to our institution for instrumented gait analysis. The SF-36 and lower limb domains of the Toronto Extremity Salvage Score (TESS) questionnaires were also administered.

Results: Partcipants scored well for general health but had functional limitations reflected in lower TESS scores. Kinematic analysis revealed decreased sagittal knee motion and valgus knee alignment. Also ubiquitous were anterior pelvic tilt and obliquity with incomplete hip extension and reduced range of hip abduction. Kinetic analysis showed reduced peak plantar flexion moment with reduced push-off power and an internal hip adduction moment in late stance. These parameters are compared to control data for below knee amputees.

Discussion and conclusions: Although the number of participants is small, this is the first study to use instrumented gait analysis for severe fibular hemimelia managed with limb reconstruction. The results add objective data to the debate over limb reconstruction or amputation in this group of children.


S McMahon J Reidy JMH Paterson

Introduction: Osteomyelitis remains a rare diagnosis and a difficult one to make. Acute osteomyelitis in the context of sickle cell disease remains the subject of some controversy, particularly with regard to aetiology. It is known that Salmonella species are more commonly the cause of acute bone infection in sickle cell patients than in patients with normal red blood cell morphology, but there has long been an argument as to whether Staphylococcus Aureus is in fact still the most common bacterial cause overall in this patient group, as it is in the population overall. We present a consecutive case series of 12 cases of acute osteomyelitis in paediatric patients in East London over the last twenty years.

Materials and Methods: Retrospective review of 12 consecutive cases. Medical Notes along with microbiology records and radiographic results were cross referenced with a paediatric sickle cell data base held by the haematology department.

Results: 10 of the 12cases had an organism isolated from either blood or bone culture(s). Salmonella spp in cases, S. Aureus in 2 cases and Pseudomonas in the remaining case

Discussion: The question of causative organism is complicated by the fact that most case series’ have bracketed adults and children together, and that conflicting conclusions have resulted from quite small, usually retrospective studies at different times and from different parts of the world – Nigeria, Saudi Arabia and the United States of America. It appears that endemicity is a result of many factors including age; race and socioeconomic factors all play a role.

Conclusion: These results reveal that in our paediatric sickle cell population, Salmonella infection occurs ore commonly than Staphylococcus.


B Kowalczyk T Lejman

Purpose: The main purpose of the study is to present our experience with the Ponseti casting followed by an Achilles tendon (AT) tenotomy in children with arthrogryposis multiplex congenita (AMC).

Methods: 7 children with 14 severe clubfeet were treated by us with a Ponseti manipulations and casting followed by AT tenotomy. 5 children (10 feet) were followed at least 24 months after the AT tenotomy and were selected for the final evaluation. Their mean age at follow up was 38,4 months and average follow up period was 35,8 months. The treatment was begun within first month of life, the AT tenotomy to correct rigid equinus was performed at 14,4 weeks of life on average, after 7–10 cast changes (mean 8,4). Niki H. et al. clinical criteria and standard standing AP and lateral radiographs were analyzed for final evaluation.

Results: There were 7 feet with clinically satisfactory results. Among 3 unsatisfactory feet there were two (1 child) with rocker-bottom pseudocorrections after repeated bilateral AT tenotomies and one recurrent clubfoot (1 child). Six feet required in soft tissue releases in 3, 12 and 21 months after the AT tenotomy due moderate equinus and adductus. 3 feet underwent repeated AT tenotomies in 6 and 15 months after the primary procedure. The mean interval between initial AT tenotomies and redo surgical procedures was 10,5 months (range 3–21 months). Two feet (20%) remain without significant deformity after AT tenotomies.

Conclusion: Clubfeet in AMC respond initially to the Ponseti method of casting and the deformity may be corrected or diminished. In some children wide surgical treatment can be avoided, in other delayed. Despite necessity for additional surgical intervention, the Ponseti method of casting and Achilles tenotomy does seem to be an alternative for initial treatment in children with AMC.


S Tennant M Sinisi S Lambert R Birch

Introduction: Shoulder relocation is commonly performed for the subluxating or dislocated shoulder secondary to Obstetric Brachial Plexus Palsy (OBPP). We have observed that even when relocation is performed at a young age, remodelling of the immature, dysplastic glenoid is often unreliable, resulting in recurrent incongruity and requiring treatment of the glenoid dysplasia.

Methods and results: In a series of 19 patients, we used a posterior bone block to buttress the deficient glenoid at the time of shoulder relocation. At a mean follow up of 28 months (6–73 months), we describe failure in at least 50% with erosion of the bone block, progressive subluxation and resultant pain.

A different technique of glenoplasty is now used. An osteotomy of the glenoid is performed postero-inferiorly, elevating the glenoid forward to decrease its volume. Bone graft, often taken from an enlarged and resected coracoid is then packed into the osteotomy and the whole assembly is held with a plate. In a series of 11 patients with a mean age of 6.7 years (1–18 years) we describe good results at short term followup, suggesting that this is a technique warranting further investigation.

Conclusion: We believe that where a deficient glenoid is found at surgery for relocation of the shoulder in OBPP, a glenoplasty should be performed at the same time whatever the age of the patient, as glenoid remodelling will not reliably occur. We no longer advocate posterior bone block in these cases as it has a significant failure rate.


N Jagodzinski R Begum S Khanum H Prem

Purpose of study: To compare our practice of paediatric foot and ankle surgery with other hospitals in the UK and to assess the safety and patient satisfaction of day-case procedures on an afternoon list.

Methods and Results: A postal questionnaire was sent to 135 consultant members of BSCOS to identify which foot and ankle operations were being performed as inpatients (“Major surgery”) and day-cases (“Minor surgery”). We received 87 (64%) replies over 3 months. The survey revealed that certain procedures were being performed as a day-case in fewer than 35% of centres in the UK. These included excision of tarsal coalitions, tendon transfers, metatarsal osteotomies and open posterior releases for equinus. These same procedures are performed routinely as day-cases at Birmingham Children’s Hospital.

We focussed on a single surgeon series with a once weekly afternoon operating list. We identified 24 “major operations” on 19 patients that were performed as a day case over 21 months. The parents of each patient were contacted by telephone to complete a satisfaction survey. We demonstrate that there were no problems that should have warranted an inpatient stay.

Conclusions: Most paediatric foot and ankle surgery can be performed satisfactorily as a day case which has obvious cost implications for the NHS. Although this is an accepted practice among adults, the majority of paediatric orthopaedic units are yet to accept this protocol.


C. J. Ingham A. Andreas Rehm

Introduction: We describe the successful treatment of advanced Perthes’ disease in 5 patients using a combined pelvic and femoral osteotomy. To our knowledge, there are no reports in orthopaedic literature describing simultaneous pelvic and femoral osteotomy as treatment for healed Perthes disease.

Method: There were 4 males and 1 female, age range 10 years to 18 years (mean 13 years). All five patients were rated as Stulberg IV. We used a Tonnis pelvic osteotomy and a 20° valgus femoral osteotomy. Clinical parameters, measured pre and post operatively, included range of movement, Harris hip and pain scores (patient and parent perception of pain on an analogue scoring system).

Results: The mean improvement in Harris hip score was 30 points and the mean reduction in pain score was 6. Range of movement was not affected. Complications included one case of non-union of the femoral osteotomy, successfully treated by open reduction and internal fixation with bone graft.

Conclusions: Simultaneous pelvic and femoral osteotomy may improve symptoms and function in symptomatic patients with healed Stulberg IV Perthes disease


S Khan C Blakey K Logan A Hashemi-Nejad

Introduction: Abnormal hip morphology, seen with conditions such as slipped capital femoral epiphyses and femoral head necrosis, can lead to repetitive contact between the femoral neck and the acetabular rim. Impingement is a significant cause of hip pain in young adults and may be a mechanism for the development of early osteoarthritis. The senior surgeon has modified a technique to debride the pathology responsible for femoroacetabular impingement through a mini anterior approach, obviating the need to dislocate the hip. We describe this technique and present early clinical outcomes.

Method: Between Jan 2006 and June 2008, ‘notchplasty’ for the surgical treatment of femoroacetabular impingement was performed by the senior author (AHN) or directly under his supervision in 38 hips. There were 17 male patients and 21 female patients with an average age of 31 years. Patients have been followed according to a prospective protocol with Oxford and Iowa hip scores obtained pre-operatively, at 3 months and at 1 year.

Results: This study is still in progress. Twenty nine patients have had 3 month follow up and 13 of these have now been followed up to one year. Four patients are still less than 3 months post op. Data was unobtainable for 5 patients. 1 patient was excluded from the study.

The overall Oxford hip score improved significantly from a mean pre-operative value of 35 to a mean post operative value of 22.9 at 3 months (p< 0.001).

The mean score at 1 year increased slightly to 27.3 points but this remains lower than the pre operative average.

We report no cases of osteonecrosis. One patient has since been scheduled to undergo resurfacing arthroplasty.

Conclusions: The technique described is a new method for managing these patients whilst avoiding the pit-falls of current operative methods. The method avoids detaching the straight head of rectus, thereby tremendously improving postoperative mobilisation. However, the long term benefit of debridement of the head-neck junction for Cam-type femoroacetabular impingement remains to be seen.


M Padman S S Madan S Jones J A Fernandes

Introduction: Obligatory external rotation during flexion is well recognised as a cardinal feature of Slipped Upper Femoral Epiphyses (SUFE). We have evaluated the significance of acetabular version in contributing to the external rotational deformity that is seen in otherwise normal hips. We present a small case series focussing on the characteristics of this pathology, highlighting its significance and outlining a treatment strategy.

Method: Five patients (eight hips) presented with disabling hip pain during non-sporting activities. All their hip radiographs had been reported as normal. The rotational profile of both acetabulum and femur in these patients was evaluated by MRI and CT scans.

Results: Clinical examination revealed otherwise normal hips but for an external rotation deformity which got worse on hip flexion. The average external rotation deformity with the hip in extension was 60 degrees, which worsened to 90 degrees during hip flexion. Three of these hips had been previously treated with in situ pinning for SUFE. Other hips were in patients who were either skeletally mature or close to skeletal maturity. We found that all were “profunda hips” with severe acetabular retroversion. The abnormality in acetabular version was best defined on axial imaging.

Conclusions: The femoral head is a spherical conchoid. The concept of version of the hip (both femoral and acetabular) as described by McKibbin, Tonnis and Ganz is reviewed. Femoral retroversion is common in patients with SUFE, but the addition of acetabular retroversion makes these hips disproportionately symptomatic. This deformity causes a combination of pincer and cam impingement, which is responsible for the marked disability. SUFE alone causes cam impingement, whilst a corresponding degree of slip without retroversion and profunda of the acetabulum is not that disabling.


T J McBride S Hutchings C E Bache

Aim: To compare outcomes in patients who suffered a severe slipped upper femoral epiphysis (SUFE) treated by either a modified Dunn or Imhauser Osteotomy.

Method: A consecutive group of patients were identified retrospectively from the operative records of a single surgeon at two hospitals since 2003. Patient Notes were used to extract age at presentation, duration of symptoms, stability, and time to surgery. Radiographs were examined to determine: the slip angle; and the degree of correction achieved. Patients were assessed using the Harris and Oxford Hip Scores.

Results: Seven patients had a modified Dunn osteotomy and 11 patients an Imhauser osteotomy. Of those only 6 of the Dunn patients and 7 of the Imhauser patients could be recalled for clinical assessment. The average time to clinical assessment from osteotomy was 13.5 months for the Dunn group and 32 months for the Imhauser group. Post-operative lateral radiographs showed a mean angle of deformity correction of 63 degrees in the Dunn and 36 degrees in the Imhauser groups. There were no postoperative complications in either group, specifically no avascular necrosis.

In the Dunn group the Harris Hip Score ranged from 78 to 100, mean 92 (excellent) and the Oxford Hip scores from 12 to 21, mean 17. The Harris Hip Score for the Imhauser group ranged from 50 to 98, mean 76 (fair), and the Oxford scores from 13 to 34, mean 25. Range of motion was similar for both groups in all directions.

Conclusions: The Dunn and Imhauser osteotomies both give good clinical results in the severe SUFE patient. However the Dunn Osteotomy group had better Harris and Oxford Hip Scores, reflecting improved functional outcome.


M N Woodsford U G Narayanan R Leahy J Janicki S Faust N M P Clarke

Introduction: Methicillin-sensitive staphylococcus aureus (MSSA) has been the predominant aetiological agent in acute osteomyelitis (AHO) in children. Recent studies from the United States have demonstrated an increase in community-acquired Methicillin-resistant Staphylococcus aureus (CA-MRSA) infections, which have been linked to increased morbidity.

Aim: a) to compare the patterns of AHO including the incidence of CA-MRSA in two tertiary children’s hospitals in Canada (The Hospital for Sick Children) and the United Kingdom (Southampton General Hospital) respectively, b) to compare the clinical course of MSSA versus CA-MRSA AHO in children in these two institutions.

Method: A retrospective review was carried out of all children up to 16 years, who were diagnosed with AHO at both centres over a five-year period. Demographic information, diagnostics, aetiology, treatment and outcomes was collected for comparison across both institutions and between MSSA and CA-MRSA identified patients.

Results: 99 cases of AHO were identified in Toronto (HSC) and 82 cases in Southampton (SGH) over the given time frames. The male: female ratios were 1.5:1 at HSC and 1.7:1 at SGH. The most commonly identified organism at both sites was MSSA, representing 42% of cultures at HSC and 22% at SGH. 2 Cases of CA-MRSA were identified at HSC, while 1 case was identified in Southampton, confirmed to be PVL-positive. No cases of Haemophilus influenzae were identified at either site. There were no significant differences in the median lengths of stay, rates of operative intervention, or complications between the two institutions. CA-MRSA cases were on average younger (7.5 yrs vs 9 yrs) and were all girls, compared with 32% girls in the MSSA group. CA-MRSA patients had similar initial laboratory profiles with the MSSA patients, except for significantly higher C-Reactive Proteins (200 vs 64) (p < 0.05). CA-MRSA patients experienced a significantly longer hospital stay (23 vs 8 days); were more likely to undergo surgical intervention (2/3 vs 34/59); were treated with longer duration of IV antibiotics (34 days vs 10.5 days); and longer total duration of antibiotics (61 days vs 46 days). 1/3 CA-MRSA patients required admission to the ICU for sepsis

Conclusions: MSSA remains the predominant aetiological agent in AHO at two large children’s hospitals in Canada and the UK. The patterns of infection are similar at both sites. CA-MRSA AHO infections have been identified at both centres, and although these remain uncommon, they are associated with a more severe clinical course. One can expect the incidence of CA-MRSA strains to rise, necessitating increased vigilance.


A Roposch G Spence R Hocking J H Wedge

Aim: To compare acetabular development and hip stability over time in patients treated for developmental dysplasia of the hip (DDH) by open reduction combined with either varusderotation (VDRO) or innominate (IO) osteotomies.

Method: Patients who underwent open reduction for DDH, combined with either VDRO (38 patients) or IO (33 patients), between 15 months and 4 years of age were reviewed. Both groups comprised a single surgeon consecutive series, differing only in the type of osteotomy performed. A total of 490 postoperative radiographs over a maximum follow-up period of 13.6 years were analyzed. We used repeated measures analysis of variance to compare the change in acetabular index (AI) as well as several other radiographic indices of acetabular development and hip stability over time.

Results: After osteotomy, the AI decreased in both groups but the magnitude of the decrease was significantly different between groups over time (p< 0.0001). The AI of patients undergoing VDRO never decreased as much as that of patients undergoing IO, with a mean difference of 10.4 degrees after 4 years (p< 0.0001). Similarly the IO group demonstrated more favourable acetabular architecture and hip stability over time compared to the VDRO group, as quantified by change in the acetabular floor thickness (p< 0.03), lateral centring ratio (p< 0.0001) and superior centring ratio (p < 0.0001).

Conclusions: Acetabular remodelling after IO was more effective at reversing acetabular dysplasia and maintaining hip stability than VDRO. Long-term follow-up of VDRO will be necessary to determine if late improvement occurs. IO may be preferable over VDRO in the treatment of hip dislocation after walking age.


M. Barakat F. Monsell

Introduction: Blount’s disease is an idiopathic, non-physiological form of genu varum. Deformity usually occurs in the proximal tibia with progressive varus, but also with valgus in the distal femur. Treatment in the infantile stage includes observation or bracing, and surgery for acute marked proximal tibial varus. Recurrence is common with conventional surgery after the age of four.

Method: A new surgical technique is proposed as definitive treatment of this condition which includes an arthrogram to visualise the knee joint, acute elevation of the varus aligned medial tibia plateau with second plane correction of posterior slope deformity, lengthening and derotation of the tibia by application of a Taylor spatial frame, application of an 8 plate on the distal femur to correct valgus deformity and finally proximal tibial and fibular epiphysiodesis to prevent recurrence.

Results: Five patients with Blount’s disease had this definitive corrective procedure performed at a mean age of 9.8. Radiographs and CT scans taken pre-operatively demonstrated marked medial plateau varus deformity and increased posterior slope. Surgery was performed by the senior author. Follow-up X-rays demonstrated satisfactory alignment, length and rotation of the lower limb.

Conclusions: This new surgical technique allows correction of all deformities of Blount’s disease at one operation and maintains alignment, length and rotation clinically and radiologically at follow-up.


M. Zgoda K. Cheng M. Osman N.I.L. Wilson

Introduction: Early treatment with antibiotics is advocated in the management of septic arthritis. Whilst some argue for mandatory arthrotomy we have used arthrotomy selectively. The results of this approach over a ten year period were reported 20-years ago.

Aim: To review the outcome of joint aspiration and selective rather than mandatory arthrotomy for the management of septic arthritis in children.

Method: We compared the outcome for cases of septic arthritis in children reported from this centre in the decade 1982–1991 (Group I) with a contemporary cohort, from 1997–2006 (Group II) using the same criteria for diagnosis and the same treatment principles.

Results: Group I comprised 61 children, Group II 42. The mean incidence of septic arthritis in children (< 13 years old) was similar for Groups I and II (2.9/100,000 and 3.1/100,000). Infection caused by Haemophilus species declined from 10 of 56 (18%) in Group I to none in Group II. Staphylococcus Aureus reduced from 27/56(48%) in Group I to 13(31%) in Group II. As previously, infections particularly of the infant hip were at highest risk of causing permanent joint damage. There were eleven (18%) sequellae in Group I and two (5%) in group II.

Conclusions: These results continue to support joint aspiration for the management of early acute septic arthritis in children. However involvement of the hip in infants requires arthrotomy, as does late (≥4 days) diagnosis in older children.


S S Madan R Maheshwari J Fernandes S Jones

Introduction: Percutaneous in situ pinning of severe SUFE can lead to problems. We describe our technique and results for surgical dislocation to reduce severe SUFE.

Method: Ganz’s approach of greater trochanteric flip, safe dissection and surgical dislocation to preserve the femoral head blood supply was followed to anatomically reduce the femoral head. We have treated 16 cases in this way, but describe nine with a minimum follow up of 2 years. Their mean age was 13.6 years (9 to 16 years). All had severe SUFE with four acute on chronic and two unstable slips. Two were previously pinned and another had a partially fused growth plate. The mean follow up was 3.1 years (2.1 to 4.6 years).

Results: All patients had a good to excellent outcome. Their pre-operative deformity was 84 degrees (65 to 110) measured by AP and cross table lateral x-rays, CT or MRI scans. The average hip external rotation deformity was 70 degrees. Post operatively internal and external rotation and all other movements were similar to the contra-lateral uninvolved hip. None developed avascular necrosis (AVN) or chondrolysis

Conclusions: This technique is demanding but can give good results for severe SUFE.


K Ho C Modi G Thomas J Gilbody I D Dunn-van der Ploeg

Introduction: The management of spasticity of children with cerebral palsy is often complex and challenging. Effective treatment requires a multidisciplinary approach involving paediatricians, orthotists, occupational therapists, physiotherapists and orthopaedic surgeons. Botulinum toxin A therapy in the lower limb has been shown to relieve spasticity and to improve the function in the short term. However, the use of Botulinum toxin A in the upper limb remains controversial.

Aim: To assess any improvement following upper limb Botulinum toxin A injections and to evaluate patient’s and parents’ expectation and satisfaction of the procedure.

Method: During 2007 a total of 36 spastic cerebral palsy patients underwent 47 episodes of Botulinum toxin A injections to the upper limb. There were 22 male and 14 female with a mean age of 6 years old. A questionnaire was devised to assess the outpatient consultation, peri-operative care and the post-operative outcome. Subjective improvement and the patient’s and parents’ evaluation of the procedure were also recorded.

Results: Good to excellent results were achieved in most areas. Daily activities were improved by 52% with an average duration of 4 months. The majority of the patient achieved their expectation. Most patients/parents were satisfied with the procedure and would consider further injections.

Conclusions: Botulinum toxin A injection to the upper limb was generally well received with good short term results. Most would consider further injections.


R A Kucharski D Campbell M J Bell

Aim: To evaluate the accuracy of ultrasound to locate the gastrocnemius musculotendinous junction (GMTJ) prior to surgery. There is no clear clinical method to precisely localise this junction, either in the paediatric or adult populations.

Method: Twenty calves in 12 paediatric patients with a diagnosis of spastic gastrocnemius muscle (GM) contracture underwent ultrasound examination prior to slide lengthening (Strayer). Surgeons did the ultrasound examination after only a short introduction to the method, using a portable ultrasound machine (Sonosite 180 PLUS) with a linear (5–10 MHz frequency range) transducer.

Only the GMTJ of medial head was located as it usually has a lower attachment and is thicker. The soleus muscle has short multipennate fibres running obliquely between aponeuroses overlying its anterior and posterior surfaces. GM has long parallel fibres and merges distally with the posterior aponeurosis of the soleus muscle. The GMTJ has a unique conical appearance on ultrasound. Pre operative skin markings were compared with the location of GMTJ during surgery.

Results: All ultrasound-guided locations of GMTJ were found to be accurate within 5mm at time of surgery.

Conclusions: This study indicates that ultrasound of the calf muscles by a surgeon prior to surgery is an accurate and reliable way of centering the incision over the GMTJ. The distinct morphological structure of the soleus muscle and overlying GM heads means that even surgeons with little ultrasound experience can perform the examination.


V. Goriainov M.G. Uglow

Aim: To determine the value of the Pirani clubfoot-scoring system at initial presentation in predicting subsequent relapse.

Method: All clubfoot patients treated by one surgeon from 2002 to 2006 were included. Treatment followed the standard protocol, involving weekly stretching and casting until the foot was corrected, followed by Achilles tenotomy and plasters for 3 weeks. Thereafter, the child was placed in a foot abduction splint.

Relapses within 6 months of instigating the foot abduction splint were classed as early and subsequent relapses as late.

The severity of clubfoot was assessed using the Pirani scoring system which comprises two sub-scores – Midfoot Contracture Score (MFCS) and Hindfoot Contracture Score (HFCS). MFCS and HFCS can each be 0.0–3.0, giving rise to a Total Pirani Score (TPS) of 0.0–6.0.

Results: Sixty-one clubfoot patients were treated, with five lost to the follow-up. A total of 89 clubfeet were treated. There were 3 early and 19 late relapses. The average interval between initiating the foot abduction splint and late relapse was 23 months. TPS median was 4.5 in the no relapse group, 4.0 in the early relapse group, and 5.0 in the late relapse group. MFCS median was 2.0 in the no relapse group, 2.0 in the early relapse group, and 2.0 in late relapse group. HFCS median was 2.5 in the no relapse group, 2.5 in the early relapse group, and 3.0 in the late relapse group. Higher HFCS was statistically significant when comparing the late and no relapse groups (p< 0.05, 95% CI −0.5–0.0).

Conclusions: Higher Pirani scores were associated with late relapses, but HFCS is a stronger predictor of potential late relapse. Close follow-up is advised for patients at risk.


N. Vasukutty B. Theruvil M. Uglow

Introduction: Previous studies on ankle arthroscopy have reported the results of treatment in adult patients. To our knowledge there are no studies reporting the out-come in children.

Aim: To analyse retrospectively the outcome of ankle arthroscopy in children.

Method: Between March 2005 and September 2007, twenty-two children (14 boys and 8 girls) underwent ankle arthroscopy for post-traumatic pathology. Their average age was 13.5 years (range 8.6 to 18). The symptoms were ankle pain (21 out of 22), instability (7) or clicking (6). Indications for arthroscopy were no response to conservative treatment, including physiotherapy, for at least 12 weeks or a grade 3 or 4 osteochondral defect (OCD) on imaging.

In five patients radiographs revealed an OCD. MR scans were obtained in eleven patients, which revealed OCDs in five, evidence of tarsal coalition in two, features suggesting posterior ankle impingement in 1 and normal scans in the remaining three.

At arthroscopy OCDs were visualised in nine cases, two of which were grade 4, four were grade 3 and three were grade 2. The grade 4 lesions were debrided and drilled, the grade 3 lesions had their edges debrided and the rest were stable. There were 3 false positive MRI scans where an OCD was reported but not seen on arthroscopy.

Impingement lesions were seen in twelve ankles (8 antero-lateral, 2 syndesmotic, 1 medial and 1 posterior), which were debrided. MRI scans had been performed in eight of these twelve cases but only one suggested an impingement lesion.

Results: Seventeen of our twenty- two patients had complete relief of symptoms at 3 months. They were back to their normal activity including sports. Three patients had persistent pain at 3 months. Two of these showed features of instability, one of which went on to have a Brostrom repair; the second had a repeat arthroscopy and debridement while the third improved with restricted activity. The average AOFAS score improved from 52 pre-operatively to 79 at 3 months following surgery.

Conclusions: Ankle arthroscopy has a successful outcome in paediatric patients with a painful ankle where conservative treatment has failed. MR imaging lacked sensitivity for diagnosing soft tissue impingement of the ankle.


V Lenin Babu A Shankar A Rignall S Jones AG Davies JA Fernandes

Aim: To review our experience with epiphysiodesis using three different methods to correct LLD and to establish the efficacy of these procedures.

Method: A retrospective review of 42 patients from 1999 to 2008 with at least one year follow-up recorded type and location of the epiphysiodesis, average operating time and hospital stay, complications, method of prediction, timing and the final LLD. CT scanograms and mechanical axis view with grids were used to assess LLD.

Results: Epiphysiodesis was as per Canale for 26, by Metaizeau screw in 14 and by staples in 2. Average operation time was 42 minutes for Canale type, 45 minutes for the screws and 56 minutes for the staple cases. The pre operative LLD of 3.7 cms In the Canale group, improved to 1.2 cms over an average follow-up of 2.1 yrs. There were 4 minor and 2 major complications with a 92% success rate. For the screw group, the mean change was 1.8 cms over 2.2 yrs with 2 minor and 2 major complications giving a success rate of 85%. With staples the success rate was 100% and the mean change was 1.8 cms at an average of 2.3 yrs. In 14 cases where bone age reports were available, the multiplier method seemed better at predicting estimated LLD at skeletal maturity and timing of epiphysiodesis than the Moseley chart.

Conclusions: Percutaneous epiphysiodesis by any method is reliable, minimally invasive and with acceptable complication rate when compared to a corrective osteotomy or open Phemister-type epiphysiodesis. Our experience suggests that the Canale method has the least complications and best success rate. Paleys multiplier method was better at predicting LLD and timing of epiphysiodesis than the Moseley Chart.


V Lenin Babu A Shankar SZ Shah MF Flowers S Jones JA Fernandes

Aim: To review our experience with hemi-epiphysiodesis using different methods for the correction of angular deformity about the knee.

Method: This was a retrospective review of 73 patients (101 knees) who underwent hemi-epiphysiodesis from 1999 to 2008. Assessment looked at the type and degree of deformity, implants used, average operating time and hospital stay, complications, degree of correction and the average time to correction.

Results: There were 50 boys and 23 girls with bilateral deformity in 28 cases. There were 88 valgus and 13 varus knees. Average follow-up was 17 months. Staples were used in 28 cases, “8” Plates in 24, Screws in 16 and Drilling in 5 cases. The distal femoral physis was involved in 46 knees, the proximal tibial physis in 21 and both physes in 34 knees (total 135 physes). Average operation time and hospital stay were similar for all methods. There were 6 minor and 3 major complications with staples with an average correction time of 14 months, 3 minor complications with an average correction time of 11 months with “8” plates, 3 minor and 1 major complication with an average correction time of 14 months with screws and 1 minor complication with drilling with an average correction time of 13 months. The outcome was considered as resolved in 47 and pending in 26 cases, with all showing progressive correction of deformity.

Conclusions: Hemi-epiphysiodesis by any method is an effective way to correct angular deformities about the knee in skeletally immature individuals within a reasonable time limit and with minimal morbidity when compared to a corrective osteotomy. Our experience suggests that “8” plates achieve faster correction with the least complications when compared to other methods. Valgus knee deformities corrected faster than varus ones.


H Sharma R Reid AT Reece

Introduction: Benign bone-forming tumours are common in children and adolescents. Careful radiographical and histological study is necessary to distinguish slow growing from more aggressive bone forming tumours. We reviewed 25 cases of primary benign bone forming tumours of the spine to investigate whether there were any obvious differences in their biological behaviour in adults compared to children.

Materials and Methods: Twenty five cases of primary benign bone forming tumours of the spine were identified from the Scottish Bone Tumour Registry: this data is collected prospectively. A retrospective review of this data was performed. There were 9 osteoid osteomas, 15 osteoblastomas and 1 aggressive osteoblastoma. These cases were divided into group A (children) and group B (adults).

Results: There were 16 patients in group A (6-osteoid osteoma, 9-osteoblastoma, 1-aggressive osteoblastoma), 10 boys and 6 girls. The mean age was 12.1 years (range, 6–16 years). There were 2 cervical, 4 thoracic, 8 lumbar and 2 sacral tumours. There were 9 patients in Group B (3-osteoid osteoma, 6-osteoblastoma), 7 boys and 2 girls. The mean age was 26.6 years (range, 18–53 years). There were 1 cervical, 6 thoracic, 2 lumbar and none sacral tumours.

Twenty two tumours were excised and 3 had curettage performed (1 child and 2 adults). There were 2 recurrences (one osteoid osteoma, one osteoblastoma), one from the excision group and one who had curettage, both in adults. These were successfully treated with re-excision. Mean follow-up was 8 years and all were alive at the time of final follow-up.

Conclusions: Benign bone forming tumours of the spine are extremely uncommon. In children they occur more commonly in lumbar spine, while thoracic involvement predominates in adult patients. Good outcomes are obtained with surgical treatment. Recurrence occurred only in the adult group: both of these patients had successful outcomes following further treatment.


V Selvaratnam J Kandasamy M Jenkinson T Pigott

Purpose: To compare the postoperative cerebrospinal fluid (CSF) leak rate in two consecutive cohorts of patients undergoing intradural spinal tumour excision with 2 different dural closure techniques.

Methods and Result: Data for this study was collected retrospectively from case notes. Between January 1994 and December 2001 forty seven intradural (thirty two extramedullary and fifteen intramedullary) spinal tumour excisions were performed. The dural incision was closed using vicryl 6.0. Operations of nine patients in this group (19 %) were complicated by CSF leak. From 2002 onwards the closure method for dural incisions was changed to single layer continuous prolene 6.0 suture in conjunction with a check valsalva manoeuvre prior to closure of wound incision in an attempt to reduce the incidence of CSF leak. Fifty three (thirty three extramedullary and twenty intramedullary) patients underwent intradural spinal tumour excision between January 2002 and October 2008. Three (5.7%) patients developed cerebrospinal fluid leak and one (1.9%) patient developed a pseudomeningocele post operatively. All four patients were subsequently managed with a lumbar drain. In both groups of patients good exposure of the proximal and distal aspect was achieved prior to dural closure. Statistical analysis comparing the outcome of both groups was performed using Fisher’s exact test – p values calculated were 0.0381 (one-tailed) and 0.0618 (two-tailed).

Conclusion: Single layer continuous prolene suture in conjunction with a check valsalva manoeuvre is superior to vicryl alone for the closure of the dura post intradural spinal tumour excision. The reduction in the leak rate may be due to the valsalva manoeuvre itself rather than the different suture material. Along with good exposure to the proximal and distal aspect of the incision we feel that this can reduce post operative cerebrospinal fluid leak in intradural spinal tumour excision operations.


A Konyves N Chiverton DL Douglas LM Breakwell AA Cole

Purpose of study: There is a controversy in the surgical treatment of unstable thoracolumbar burst fractures scoring high on the Load Sharing Classification (LSC). We have been treating unstable thoracolumbar fractures with postero-lateral fusion using short segment instrumentation and in this study we investigated our complication rate.

Methods and results: We retrospectively reviewed notes and radiographs of patients presenting with thoracolumbar burst fractures and stabilised with a short-segment instrumented postero-lateral fusion between 1998 and 2007. We identified 31 patients who had adequate documentation and radiographs. Twenty patients had a high (> =7) LSC score and none of these fixations failed. Overall early and late complication rate was low (one wound infection, one dehiscence and four unrelated infections), the one metalwork failure related to infection. Fifty-five percent of patients returned to full-time work. Approximately 50% of correction of kyphosis was lost but the average kyphosis at final follow-up was 11 degrees that we thought was acceptable.

Conclusion: We concluded that treating unstable burst fractures with posterior instrumented fusion alone using a pedicle screw construct does not result in late instrumentation failure, high complication rate or unacceptable final deformity.

Ethics approval: None

Interest Statement: None


H Sharma R Reid AT Reece

Introduction: A retrospective analysis was performed to determine the oncological outcome of patients with Ewing’s sarcoma of the spine treated with combined chemotherapy and radiotherapy for definitive local control.

Materials and Methods: Fifteen patients were identified from the Scottish Bone Tumour Registry with a histologically confirmed Ewing’s sarcoma affecting the axial skeleton. All case notes and imaging were retrospectively reviewed.

Results: Primary vertebral Ewing’s sarcoma accounted for 8.3% of all malignant spinal lesions in our registry. The mean age was 17.8 years (between 4 and 39 years). There was a male predilection with 9 male and 6 female patients. Site was evenly distributed between cervical (4), dorsal (5) and lumbosacral (6) regions. Progressively worsening back pain was the first symptom in all the patients. Satisfactory imaging studies were available in all with plain radiographs (15), bone scan (11), CT-scan (12) and MR Scan (9) patients.

Biopsy was performed in 11 patients and surgical treatment was carried out in 3 patients including curettage (2) and excision with bone grafting (1). All patients were treated with adjuvant radiotherapy while 87% also received adjuvant chemotherapy. Seven patients were alive with no evidence of disease at a mean 6 year follow-up. Six patients died of metastatic disease, one due to local recurrence and one with persistent primary disease. The mean follow-up time was 65 months (median 28 months; ranging from 12 to 218 months).

Conclusions: Primary vertebral Ewing’s sarcoma comprised 8.3% of our National Registry’s primary malignant spinal lesions. Progressive vertebral pain in the late second decade and male gender should raise the suspicion of Ewing’s sarcoma. Ewing’s sarcoma of the spine treated with combined chemotherapy and radiotherapy for definitive local control achieved a 45% five year survival.


AJ Highcock L Moulton K Rourke M de Matas R Pillay

Introduction: The management atlanto-axial fractures, particularly those of the odontoid peg, remains controversial. We managed patients with C1/C2 fractures non-operatively in rigid immobilization until CT-scanning confirmed bony union, rather than for the standard 3-month period. We examined whether this improved outcomes and reduced the need for surgery.

Method: All patients admitted to our unit with atlanto-axial fractures between 2001–2007 were retrospectively analyzed. All fractures had the ‘intention-to-treat’ conservatively in either halothoracic vest (85%) or Aspen collar (15%). Rigid immobilization was maintained until CT-scanning demonstrated bony fusion. Functional stability was subsequently assessed with flexion-extension radiographs after removal of rigid immobilization.

Results: Twenty-seven patients were studied. Nineteen had odontoid peg fractures (10 type II; 9 type III). The remainder consisted of 3 Hangman’s, 3 lateral mass and 2 atlas ring fractures. 83% of patients progressed to union at an average of 13.2 weeks (range 5–22). Six complications related to halo immobilization were observed (three skull perforations/pin-site infections). All of these patients progressed to union non-operatively.

Failure of non-operative management was deemed as non-union or poor patient tolerance of halo, and occurred in 4 patients (17%). All four had type II odontoid peg fractures, and had transarticular screw fixation. One postoperative complication of screw fracture was recorded.

Conclusion: Non-union rates of conservatively managed atlanto-axial fractures with standard 3-month rigid immobilization have been reported as high as 35%. In our series, CT-imaging to confirm bony union prior to removal of the rigid immobilization (prolonging immobilization where necessary) significantly lowered the rate of non-union and therefore the need for subsequent surgery.

Ethics approval: None Audit

Interest Statement: None


RJ Newsome M Reddington LM Breakwell N Chiverton AA Cole

Purpose: To investigate whether patients who present with Lumbar radicular signs and symptoms and who have MRI scans reported as showing no nerve root compression, improve following Nerve Root Injection (NRI).

Methods: The clinic notes and MRI results of 127 patients who underwent NRI under the care of two spinal surgeons were reviewed retrospectively. Those patients with radicular pain and MRI scans reported as showing no nerve root compression were evaluated further. All patients had a selective NRI using a standard image intensifier guided oblique approach with 40 mg Kenalog and 1 ml 0.25% bupivacaine injected around the nerve root. The patients’ symptoms and signs were noted at the follow up appointment six weeks later.

Results: 43 of the 127 patients who underwent selective NRI had MRI scan reports suggesting no nerve root compression. Of the 47 patients 30 (69%) reported a significant improvement (p=0.0009) in their leg pain following the NRI, the remaining 13 patients reported no relief.

Conclusions: Clinicians treating patients presenting with lumbar radicular signs and symptoms should not rely on MRI report alone in the diagnosis and management of the patient. The results show that patients who exhibit lumbar radicular signs and symptoms who have non-concordant MRI results may still benefit from treatment (NRI).

Ethics approval: None required

Statement of interest: None


D Makki R Francis D Hamed R Nawabi A Hussein

Purposes: To assess the influence of patients’ positioning following caudal epidural injections on the outcome.

Methods and Results: 58 patients with low back pain and sciatica undergoing caudal epidural injection were prospectively and randomly allocated into 2 groups. 28 patients (Group 1) were positioned on the side (same side of sciatica) following the injection while 29 patients (group 2) were laid on the back. Patients were assessed using Oswestry disability index and the leg pain intensity was scored using Numerical pain intensity scale before surgery and after 6 weeks following the procedure. Pre-and postoperative pain scores were reviewed for each individual patient and the rate of improvement or worsening was noted. In group 1, 92.8 % of patients had their leg pain improved and 7.2 % remained unchanged. In group 2 however, 77% of patients did improve whereas 13.7% failed to do so and 6.8 deteriorated on the pain scale. There was a statistically significant difference in the degree of pain score improvement in favour of Group1 (Mean: 2.75 points on the scale for group 1 versus mean: 1.31 for group 2, P< 0.001, Mann-Whitney test). No difference was noted between the two groups in the improvement in the disability index (P< 0.14).

Conclusions: Lying on the symptomatic side following caudal epidural injection has improved the result in terms of pain control. Such a simple manoeuvre could add benefit to the injection in terms of pain for which the procedure is mainly indicated. The longstanding functional disability remained unchanged.

Ethics approval: None

Interest Statement: None


RS Ahluwalia JM Powell DJ Sharp NA Quraishi

Introduction: There is little evidence for the long term efficacy of selective nerve root injections (SNRI) in the control of lumbar radiculopathy. We report the 5 year results of a prospective study of SNRI in the lumbar spine.

Methods: All patients considered to be operative candidates by two treating surgeons (JMP and DJS) with unilateral/bilateral radicular leg pain were included. Patients had a mean history of radicular symptoms of 12.8 months (4 months–3 years). All had an SNRI under image intensifier control with local anaesthetic and steroid. Each patient was evaluated pre-operatively, 2 months, 6 months, 1 year, 2 year and 5 years with VAS and ODI scores.

Results: Sixty-two consecutive patients were reviewed. The mean age of patients was 54.5 years (36–80 years). 92 injections were performed. Symptoms were caused by degenerative disease (n=32), disc herniation (n=25), and previous surgery (n=3).

The ‘disc’ group was significantly younger than ‘degenerative’ group (49.4 yrs vs. 58.4 yrs; p=0.004). There were significant improvements in low back pain (LBP), leg pain (LP), and ODI at 2 months in all patients. At 5 years the disc group did better with both leg and back pain; whilst there was only a significant reduction in leg pain in the degenerative group. Over 90% (n=56) of patients had no operative intervention; a subgroup of 8 had further injections. Within the degenerative group, ODI and VAS deteriorate early on indicating that a second injection option in this group may be worthwhile.

Conclusion: At five-years, most patients avoid operative treatment because of improved symptom control with SNRI. Regression analysis showed “duration of symptoms” and “age” is predictive of good outcome at one year post SNRI, but gender and, diagnosis are not.


RS Ahluwalia A Karthikesalingam NA Quraishi

Background: Nerve Root pain is a problem caused by mechanical compression from disc herniation or foraminal stenosis, which stimulates an inflammatory response. We present a review of the evidence for corticosteroid infiltration in nerve root infiltration (NRI).

Methods: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised controlled trials of the use of NRI in the treatment of radicular pain. For the purpose of this meta-analysis, the control group “no steroid” was chosen to encompass various subtypes. The primary outcomes were Oswestry Disability Scores (ODI) and Visual Analogue Scores (VAS) for pain. Outcomes were compared at 3 and 6 months from injection. For the purpose of the meta-analysis, repeat injection and progression to surgery are grouped as a composite endpoint.

Results: We identified 96 papers; but only 5 RCT’s which included 402 patients receiving NRI; 202 were randomised to receiving steroids. No trials reported significant intergroup differences in baseline VAS or ODI.

At 3 months there was no significant difference in VAS or ODI between the groups. Only two trials reported ODI data at 6 months but a significant effect in favour of the control arm was noted (P = 0.040). Four of the five trials reported the need for further injection or surgery due to failure but no significant difference between the groups was found (P = 0.038).

Conclusion: Our analysis suggests that the addition of steroids to local anaesthetic agents or placebo solutions confers no additional benefit, but the theoretical risk of infection. Further information is needed on hospital stay, economic and long term responses, and is required to counter confounding with small trials and study numbers, and any methodological heterogeneity.


GS Barham A Hilton

The study was designed to quantify the hit/miss ratio of non-radiologically assisted caudal epidurals, assessing both accuracy of entry into the epidural space and adequacy flow of contrast and therapeutic agents to the level of pre-defined pathology.

We studied 146 consecutive patients listed for a caudal epidural under sedation for either radicular pain or spinal stenosis. When the surgeon was happy with placement of the needle its position was assessed using image intensifier and injection of radio-opaque dye (Omnipaque). The epidurogram was also used to confirm the level of pathology had been reached by the steroid and local anaesthetic.

Three patients were excluded because of inadequate records. Five patients did not attend for their procedure. Of the remaining 138 patients Consultant spinal surgeons carried out 75 procedures and the remaining 63 cases were performed by “middle grade” surgeons. 36 of 138 patients (26%) had placement of spinal needle outside the epidural space after first blind placement. Hit rate was not related to surgeon grade, patient age or patient diagnosis. In 6% of cases the radio-opaque dye did not reach the level of documented pathology had been reached by the dye. 2 patients had a “spinal” pattern of block requiring overnight admission, there were no other complications recorded.

A miss rate of 26% in the blind placement of spinal needles through the sacral hiatus in caudal epidurals is unacceptable. We would therefore recommend position of the needle is confirmed radiologically and epidurogram is used to confirm accurate delivery of the therapeutic agents.

Interest statement: none

Ethics approval: none (study of current practice)


A Sivaraman F Altaf AK Bhadra A Singh AS Rai AT Casey RJ Crawford

Objective: We prospectively compared the techniques of skip laminectomy and laminoplasty for the treatment of cervical spondolytic myelopathy in terms extent of decompression achieved, axial pain, postoperative range of cervical motion, patient and surgical outcomes.

Methods and results: We studied fifty consecutive patients operated on for cervical spondolytic myelopathy and spinal cord compression as demonstrated on MRI between the levels C3–4 to C6–7. Each patient had a minimum follow-up of two years (2.2 – 4.3 years). Twenty-five patients underwent skip laminectomy and twenty-five patients underwent laminoplasty. Decompression was assessed by pre- and post-operative MRI. Cervical range of motion was assessed by pre- and postoperative flexion and extension radiographs. Patient outcomes were assessed by evaluation of pre-and postoperative neurology and SF12 scores for mental health, physical health and axial pain.

Less blood loss and operative times were found with skip laminectomy. Similar degrees of decompression with both techniques. Significantly improved axial pain scores with skip laminectomy. Significantly improved preservation of range of movement with skip laminectomy.

Conclusion: Skip laminectomy is an effective procedure for reducing the incidence of postoperative morbidities, such as persisting axial pain, and restriction of neck motion often seen after laminoplasty, and provides adequate decompression of the spinal cord as demonstrated on MRI for a minimum follow-up of two years.


VN Vakharia MJ Guilfoyle RJ Laing

Objective: To assess outcome in patients with syrinx and non-syrinx associated Chiari malformations undergoing Foramen Magnum Decompression (FMD).

Methods: 61 patients undergoing FMD for Chiari malformations were prospectively studied with disease specific, generic (SF 36) and subjective (surgeon assessed) outcomes. 34 patients had complete data. Disease specific outcomes were visual analogue pain scores, Neck and Myelopathy disability indices and the Hospital anxiety and depression score. SF 36 scores were compared to normative data. Data were collected pre-operatively, at 3 months and during long-term follow up (12–60 months).

Results: Subjective improvements in headache and neck pain post-operatively were seen in both syrinx and non-syrinx associated patients. Visual Analogue scores showed an improvement in Arm pain, Paraesthesia and Hand tingling by 3 months in the syrinx group only. Non-syrinx patients showed significant improvement post-operatively in the Neck disability index and the SF-36 domains for physical function, role physical and bodily pain by 12 months. Comparison with the SF 36 normative data showed that patients still have significantly impaired quality of life 12 months post operatively despite the improved scores achieved following surgery.

Conclusion: FMD is able to relieve symptoms and improve quality of life in patients with both syrinx and non-syrinx associated Chiari malformations. The SF-36 data presented in this paper allows the health gain associated with FMD to be quantified but its utility as a sole measure of outcome in this complex disorder will be discussed.

Ethics approval: None

Interest Statement: None


J Cowie I Beggs JNA Gibson

Background: Several recent studies have compared incorporation of autograft with that of allograft or synthetic bone substitutes in anterior cervical discectomy and fusion (ACDF). These studies have almost universally relied on plain radiography to assess bone incorporation despite the fact that we know, from similar lumbar spine studies, that bone ingrowth is over-estimated.

Our aim was to determine the exactly whether bone incorporation may be correctly assessed by this method by comparing the results to those obtained by spiral CT imaging.

Methods: 15 patients underwent ACDF. Helical CT scans were obtained. Fusion was defined as trabecular continuity across the disc space anterior, through and posterior to the cage proximally and distally and assessed by two of the authors independently.

Results: 14 of the 15 patients appeared to have solid incorporation of bone graft/substitute on plain radiography, 19 out of 20 cages. These findings were not however replicated on CT imaging. The autograft was not considered to have been incorporated proximally above the cage in 5 cases and distally in 6 cases.

Discussion: The implication of our results is that there is at least a false positive rate of bone incorporation of 20–25%. Pseudarthroses are generally painful and therefore we would recommend that spiral CT imaging is performed in patients who have ongoing pain following ACDF.

Ethics approval: COREC Ethics committee number 06/S1104/34

Interest Statement: None of the authors have received any grants to carry out this research.


JR Panchmatia ATH Casey

Statement of purpose: To profile the neurological lesions associated with scoliosis, evaluate the role of preoperative MRI and determine the proportion of patients requiring surgery for an intradural lesion.

Methods: The records of patients undergoing surgery to treat scoliosis over a 5 year period were reviewed as part of this retrospective single centre study.

Results: 1926 patients underwent 2714 procedures to treat scoliosis. 45 patients from this cohort were referred for an opinion regarding at least one of the following neural axis abnormalities: Syrinx (47%); Chiari malformation and cerebellar ectopia (40%); tethered cord (13%); persistent central canal (9%); diastematomyelia (7%); neurofibromata (7%); syndromes other than neurofibromatosis (7%); tumours (4%) and vascular lesions (2%).

18 patients underwent surgery to treat a neural axis lesion: Foramen magnum decompression (12); cord untethering (4) and the surgical treatment of diastematomyelia (2).

Conclusions: The authors believe their series to be the largest to date.

Preoperative MRI scans should extend from the cranio-cervical junction to the sacrum, reflecting the potential locations of neural axis lesions.

Radiologists present at units treating scoliosis should be able to identify both commonly occurring lesions such syrinx and intradural pathology.

A significant proportion of patients required surgery to treat their neural axis lesions. Centres treating patients with scoliosis should therefore have the necessary facilities to treat not only scoliosis but also its associated intradural spinal lesions.

Ethics approval: None Audit

Interest Statement: None


JCD Leach EAC Pereira H Chandran TAD Cadoux-Hudson

Purpose of study: To demonstrate the safety and efficacy 3 and 4-level ACDF with stand-alone (no additional anterior fixation) intervertebral cages.

Methods and results: A consecutive cohort of 19 patients undergoing 3 (n=15) and 4-level (n=4) ACDF with Solis cages over 4 years was studied (mean follow-up 24 months). Outcome measures were clinical (VAS scores for neck and arm pain, myelopathy scores) and radiological (disc height, kyphotic angles, fusion).

Neck pain scores improved from 5.1 pre-operatively (range 0–10, s.d. 4) to 2.8 post-operatively (range 0–10, s.d.5), t=3.7, P< 0.0002.

Arm pain scores improved from 5.3 pre-operatively (range 0–10, s.d. 5) to 2.5 post-operatively (range 0–8, s.d. 3), t=2.8, P< 0.009.

Pre-operative myelopathy scores averaged 10.6 (range 7–16, s.d. 4.7) rising to 12.8 post-operatively (range 10–17, s.d. 3.9). Although there was no statistically significant change in myelopathy scores, no patient experienced a worsening of their myelopathy score after surgery.

There were no operative complications. Radiological follow-up demonstrated early improvement in disc space heights (pre-op 3.1 mm, range 1–6 mm; post-op 5.6 mm, range 4–9 mm) but, at 12 months, two patients demonstrated asymptomatic evidence of cage settling and loss of disc height. There was no incidence of pseudarthrosis. No patient has thus far required further surgery.

Conclusion: Multi-level cervical disc disease can be managed safely and effectively by 3 or 4-level discectomy and fusion with stand-alone intervertebral cages.

Ethics approval: None – audit

Interest Statement: None


AA Kamat NA Farroqi JJD Bosma

Purpose of study: Cervical corpectomy is a well established procedure for spinal pathology. We have applied this technique using a titanium standalone cage or a cage with cervical locking plate filled with bone debris of the corpectomy for vertebral reconstruction. The study was aimed to determine the efficacy and assess the morbidity of this procedure.

Methods: Case notes of all patients who underwent cervical corpectomy from March 2004 to September 2008 were reviewed retrospectively.

Results: 47 patients were identified 28 male and 19 female. The mean age was 58 (range 40 to 82). Single level corpectomy was performed in 21 patients, 2 levels in 19 and 3 levels in 6 patients. One case was abandoned and one had additional laminectomy and lateral mass fusion. 89% of cases needed corpectomy for degenerative disease, whilst 11% for malignant disease.

Complications included dural tear in 5 patients, subsidence in 4, laryngeal nerve palsy in 2, postoperative haematoma in 2 and infection in 1 patient.

At mean follow-up of 25 months (range 3 to 52), 84% were better, 10% remained same and 4 % of patients worsened.

Conclusion: Cervical corpectomy is a safe and effective method of managing cervical pathology. It not only provides stable vertebral reconstruction but also eliminates donor graft site related morbidity.

Ethics approval: None Audit/service standard in trust Ethics committee COREC number:

Interest Statement: None Local grant/National grant Commercial/industry support


E Bayley Z Zia R Kerslake Z Klezl B Boszczyk

Aim: In sub-axial cervical vertebrae the lamina appears to project perpendicular to the ipsilateral pedicle axis, and forms a reliable trajectory for avoidance of vertebral artery injury in lateral mass (LM) screw placement: the aim is to confirm these observations.

Material and Methods: 51 digital cervical spine CTs (255 vertebrae; 25 female 26 male; mean age 37.4 range:18–80). Exclusions: Severe degeneration, malformation, tumour, trauma.

Measurement (axial view):

Angle of ipsilateral outer lamina cortex to pedicle axis

Virtual screw trajectory 2 mm from and parallel to the lamina was placed through the LM. Potential violation of the transverse foramen and LM width available for screw purchase was assessed

Results: Average lamina-pedicle angle (standard deviation):

Females: Right: C3–84.8°(2.6), C4–85.2°(3.1), C5–86.7°(3.3), C6–89.2°(2.5), C7–92.3°(2.4);

Left: C3–84.0°(3.1), C4–84.5°(3.9), C5–86.6°(3.7), C6–89.6°(2.6), C7–92.1°(2.3)

No significant difference between males and females (P< 0.05)

Violation of transverse foramen C3–C7: 0%

LM width (trajectory parallel to LM) in millimetres (standard deviation):

Males: Right: C3–5.5(0.7), C4–6.1(0.7), C5–6.8(0.8), C6–7.1(1.1), C7–6.1(1);

Left: C3–5.2(0.8), C4–5.9(0.8), C5–7(1.2), C6–7.3(1.1), C7–6.3(1.4)

Females: Right: C3–5.3(0.8), C4–5.5(0.9), C5–6.6(1.2), C6–6.3(1.3), C7–5.4(1.4);

Left: C3–5.2(1), C4–5.7(1), C5–7.1(1.1), C6–6.5(1.3), C7–5.5(1.6)

Conclusion: The angle formed by the lamina and ipsilateral pedicle ranges from 84° at C3 to 92° at C7. Although the angle is not exactly perpendicular at all levels as hypothesised, the lamina forms a useful reference plane for pedicle screw insertion in the sub-axial cervical spine.

LM screws placed parallel to the lamina find sufficient LM width and are highly unlikely to injure the vertebral artery in bi-cortical placement. This technique appears favourable over conventional 30° LM placement.

Ethics approval: None needed

Interest Statement: None


P Sell M Newey

Purpose: To determine the clinical effectiveness of a stand alone interspinous distraction device

Method: Prospective consecutive longitudinal study in five hospital sites. Outcome measures Oswestry Disability Index (ODI), Visual Analogue score for leg and back (VAS Leg, VAS Back). Implant failure determined by removal and revision.

A cohort of 69 patients having clinical and radiological evidence of spinal stenosis. Selected according to recommendations of clinical trials groups for the x-stop, i.e. sitting tolerance of greater than 30 minutes.

Clinical outcome data at average of 10 month (6–24) available for 66 patients (95% FU).

Average age 67 years ( Range 49–84). The average outcomes were Pre op ODI 42, Post op ODI 27. A change from baseline of 15 points. Pre op VAS leg 7.2 post op 4.4, and VAS Back Pre 4.8, post op 3.6

Taking a 16 point change in ODI as representing a clinically significant improvement half the study group failed to achieve this. A small number (17 patients 25%) had a dramatic improvement of greater than 24 points, which significantly skews the average change from baseline.

17 Revisions have occurred so far (24% failure rate)

Conclusion: A small proportion of successful results occur, however implant failure and revision rate is high.

Ethics approval: NPIAG registered audit

Interest Statement: No commercial or grant support


CE Gilkes JC Hobart T Germon

Purpose: To determine if the short term benefits we reported from X STOP implants for lumbar radiculopathy were maintained at 2 yr follow up

Methods and Results: We followed all patients, of one neurosurgeon (TG), having XSTOP implants to treatment lumbar radiculopathy secondary to foraminal stenosis. We measured patient-reported pain and disability outcomes (Oswestry disability index, ODI; Short Form 36 bodily pain scale, SF-36 BP) immediately pre-op and approximately 2 years post op. Changes were examined in terms of statistical significance (Wilcoxon signed ranks test) and clinical significance (effect sizes – mean change divided by SD change).

2 yr follow up data were available for 13 of the 15 people who had the surgery. One had died of an unrelated condition before follow up, the other had further lumbar surgery thus affecting the interpretation of the data. Mean duration of follow up was 30.5 months.

Both ODI and SF-36 BP detected sustained improvements 2 yrs after surgery. Results for both scales were statistically significant (z = −3.059 & −3.062; p = 0.002). Mean change scores for both scales were substantial (ODI = 31.7; SF36 BP = 47.4), and effect sizes were very large (ODI = 1.35; SF-36 BP = 1.37) indicating clinically significant improvement. There have been no complications.

Conclusions: These provisional data, albeit from a small sample, provide increasing evidence to imply that the X STOP procedure may suit people with radiculopathy secondary to foraminal stenosis. Moreover, it has been safe and does not jeopardise future surgery in the event of failure.

Ethics approval: None, Audit

Interest Statement: None


P Sell

Purpose: To describe the clinical, biomechanical and radiological features of a spinal implant failure

Method: Over a two year period 45 patients had treatment of spinal stenosis with the X-stop device. 38 had a single level treated, 7 had two level implants. Average age 68. Pre op walking distance 120 meters, Pre op Oswestry Disability Index (ODI) 45%.

11 patients have had implants removed, a 24% implant failure rate. Clinical failure also occurred in two patients unfit for revision. Prospective data on standard spine outcomes were analysed as well as the radiological and biomechanical features of failure.

Results: One year survivorship was 71%. At 6 months the average walking distance improved to 1430 meters, and the average ODI improved to 26%. Some patients exhibit dramatic improvements which obscures the failures.

There were two modes of failure, early, with a failure to improve after the procedure, and late, with an initial improvement and subsequent deterioration.

A consistent feature of late failure is bone resorption around the implant. This is apparent on post operative radiographs and is a progressive. Scalloping and erosion of bone is seen at revision surgery with the implant within a fibrous capsule. Late spinous process fracture occurred in a two level implant as a result of erosion.

Retrieved implants demonstrate scouring of the PEEK surface which increases with time.

Conclusion: Long term surveillance should be mandatory. The implant should be withdrawn from clinical use until trials establish long term efficacy and safety.

Ethics approval: Registered with Hospital new procedures advisory group audit

Interest Statement: No commercial support


M Katsimihas CS Bailey K Issa P Rosas-Arellano SI Bailey K Gurr

Purpose: To report the clinical and radiographic prospective results of a consecutive series of patient with a minimum two year follow-up with the Charite Total Disc Arthroplasty (TDA).

Methods: Between 2001 and 2005 sixty patients underwent a Charite TDA (Depuy Spine, Raynham, MA) at either L4–5 or L5-S1. The primary indication for surgery was discogenic low back pain confirmed by provocative discography. Clinical assessment was carried out preoperatively and postoperatively at 3, 6, 12 months, and once a year thereafter using the Oswestry Disability Index (ODI), Visual Analogue Scale (VAS) for back and leg pain, and SF-36. Radiographic analysis included: angle of sagittal rotation, translation of the rostral vertebra onto the caudal vertebra, anterior vertical motion (AVM), middle vertical motion (MVM), posterior vertical motion (PVM), pre- and post-operative lumbar lordosis, disc height and subsidence of the TDA. The radiographic measurements were performed using the GE Medical Systems Centricity PACS Software Version 1.0.

Results: There were 36 female and 24 male patients with a mean age of 39 (range 21–59). The mean duration of low back pain was 70 months. Twenty-five percent claimed work compensation status. The mean post-operative hospital stay was 4.8 days. A statistical significant improvement was demonstrated between the mean pre-operative ODI (50) and all post-operative intervals (p< 0.0001) which had declined to 27.7 by one year. Similarly, pre-operative VAS back pain (8.0), leg pain (6.1), SF-36 physical component summary score (33.5) and mental component summary score (41.8) remained improved (p< 0.0001) by three months (4.1, 3.1, 51.7, 62.0 respectively).

The mean pre and post-operative lumbar lordosis was 34.58 and 53.48 respectively. The mean sagittal rotation was 6.5 degrees at 5 year follow-up, while the mean translation was 0.83 mm. The mean AVM, MVM and PVM were 0.59 mm, −3.96 mm and 3.69 mm respectively at 5 year follow-up.

Conclusion: This study demonstrates satisfactory clinical results in carefully selected patients. The radiographic assessment confirmed preservation of movement at the replaced disc during flexion and extension of the lumbar spine.

Interest Statement: No financial benefits or funding has been received for the completion of this study.


M Reddington N Chiverton

Aims: To establish whether self rated disability and physical function in people with Chronic Low Back Pain (CLBP) are correlated.

Design/Methods: The study was observational/correlational in design. One hundred patients attending orthopaedic surgical clinics or for physiotherapy at the Northern General Hospital (NGH) site of Sheffield Teaching Hospitals (STH) were recruited for the study. Once consent was obtained patients were asked to complete the Oswestry Disability Index (ODI) and undertake the Harding battery of physical performance.

Results: The Pearson product moment correlation coefficients were calculated for the group using SPSS v.13. The results show low negative correlations for the whole group with low to moderate negative correlations for the male group. There were no statistically significant correlations for the physical performance measures and ODI in the female sub-group.

Pearson correlation Co-efficient results for all participant

Conclusions: The lack of correlation between self-rated disability and physical performance suggests that the two constructs are un-related and as such should be measured separately. There were significant differences between the physical performance parameters between genders. This enhances the findings of previous studies which, together with this study suggest that the level of physical performance should not be extrapolated from self-rated disability questionnaires.

Ethics Approval: The study was approved by the North Sheffield ethics committee (ref: 07/H1308/120) and Sheffield Teaching Hospitals NHS Foundation Trust (ref: STH 14280)

Statement of interest: None


M Katsimihas CS Bailey A Ignitiuk J Fleming K Issa P Rosas-Arellano SI Bailey K Gurr

Purpose: To investigate subsidence of the Charite total disc arthroplasty (TDA) and to identify if a discrepancy between vertebral endplate and the Charite footprint predispose to subsidence.

Methods: Between July 2001 and May 2008 64 patients underwent a Charite TDA (DePuy Spine, Raynham, MA). They were prospectively followed at 3, 6, 12 months, and once a year thereafter.

The following measurements were performed on the replaced motion segment using a lateral radiograph:

The anterior-posterior (AP) dimension of the end plates.

Amount of subsidence.

The distance between the TDA and the posterior and anterior borders of the vertebra bodies (to represent the extent of uncoverage of the endplate by the TDA).

The AP dimension of the TDA metal endplate.

The ratio between the actual and radiographic AP length of the metal endplate was calculated and utilized as the correction factor for the error of magnification on all other radiographic measurements.

Results: At L5-S1 the mean subsidence was 1.87 mm and occurred exclusively at the posterior part of the inferior end plate of L5. The mean posterior uncoverage was 3.5 mm (L5) and 0.27 mm (S1).

At L4–L5 the mean subsidence was 1.48 mm (L4) and 0.56 mm (L5). Posterior uncoverage of L4 and L5 vertebrae were 4.81 and 2.22 mm, respectively.

Subsidence of more than 1 mm was present in all cases where the posterior uncoverage of the end plate with the TDA was more than 2 mm (odds ratio: 5.7). Subsidence was non – progressive in all cases.

An anatomic mismatch exists between L5 and S1 endplates in the AP dimension; in more than half the patients S1 is shorter than L5.

Conclusion: The radiographic measurements suggest an increased likelihood of subsidence with more than 2 mm of posterior uncoverage of the end plate by the TDA. The endplate AP length of S1 is frequently less than that of L5. Implant selection based on the smaller S1 endplate may produce worrisome uncoverage of the L5 inferior endplate leading to an increased risk of subsidence and possible catastrophic failure. TDA design should afford modularity to compensate.

No financial benefits or funding has been received for the completion of this study.


KT Tsang JC Hobart N Sudhakar TJ Germon

Aims

to determine what aspects of people’s lives (domains of impact) where most affected by their spinal problems,

to determine the extent to which the SF-36 and ODI represent these domains,

to compare the domains of impact resulting from neck and low back pain.

Methods & Results: Data was collected prospectively. New patients attending the spinal clinic completed a questionnaire about their symptoms. They were also asked to list, in order of importance to them, the 3 aspects of their daily life most affected by their symptoms. Responses were in free text format, summarised with the most appropriate single word response (e.g. walking) and grouped. Thoraco-lumbar and cervical pain/pathology were analyzed separately. We computed: (1) the total number of domains of impact identified; (2) the frequency (%) each domain was listed 1st; (3)the frequency (%) each domain was listed 1st, 2nd, or 3rd

Cervical pathology (n=200 people).

19 domains were identified. Of domains identified as first most important (n=164) 3 domains predominated: work (28%), sleep (24%), walking (24%). Others ranged from 0 – 7.6%. Of all domains identified by all people (n=399), 4 predominated: sleep (62%), work (54%), walking (41%) sitting (36%). Others ranged from 0.6% to 9.8%.

Thoraco-Lumbar pathology (n=537 people).

25 domains were identified. Of domains identified as first most important (n=429) 4 domains predominated: walking (49%), working (18%), sitting (12%) and sleeping (11%). Others ranged from 0 – 7.6%. Of all domains identified by all people (n=1096), 4 predominated: sleep (76%), work (50%), walking (47%) sitting (45%). Others ranged from 0.2% to 11.9%.

Conclusions: People with spinal problems consistently identify 4 main domains of impact: working, walking, sleeping and sitting. This is not reflected by SF-36 and ODI. Further work is required to ensure that scale selection for assessing the impact of spinal pathology and its management is evidence based.

Ethics approval: none

Interest statement: none


S Chaudhry P Fenton D Baker D Sethi M Grainge

Racial and ethnic disparities in pain perception diagnosis and management have become apparent in different specialities.1,2 We aimed to assess the differences in symptom perception, as expressed in the oswestry disability score, between different ethnic groups in a UK population before and after surgery.

Oswestry Disability Scores (ODI) (completed at every outpatient visit), and other information were obtained retrospectively for 1568 patients seen at our spinal unit over the last two years. Statistical analysis using analysis of variance (ANOVA) was used to determine any true difference in ODI scores between Caucasian, Afro-Caribbean and South Asian different groups pre and post surgery.

Overall scores were significantly higher for the South Asian group when compared with the white using analysis of variance (ANOVA) p< 0.001. Afro-Caribbean patients also showed a trend to higher overall scores from the white group p=0.091 (least squares difference post-hoc test).

From a total of 280 patients who had undergone surgery, South Asians had significantly higher pre-operative scores compared to Caucasians (p> 0.001). Afro-Caribbean’s also scored higher than Caucasians pre-operatively although the difference was not significant (p=0.091). Scores for South Asians and Afro-Caribbean’s remained higher than those for Caucasians postoperatively. All groups however, did show a statistically significant reduction in ODI score compared to the pre-operative score.

Despite the differences in symptom perception or expression we have found to exist between ethnic groups, we conclude that in appropriately selected patients, this does not affect their ability to benefit from surgery

Ethics approval: none

Interest statement: none


Full Access
GFG Findlay B Balain DC Jaffray JM Trevedi

Introduction: There is still no standard approach to applying the Romberg test in clinical neurology and the criteria for and interpretation of an abnormal result continue to be debated.

Methods: Detailed clinical examination of 50 consecutive patients of cervical myelopathy was performed prospectively. For the walking Romberg sign, patients were asked to walk five metres with their eyes open. This was repeated with their eyes closed. Swaying or inability to complete the walk with eyes closed was interpreted as a positive walking Romberg sign. This test was compared to common clinical signs to evaluate its relevance.

Results: Whilst the Hoffman’s reflex (79%) was the most prevalent sign, the walking Romberg sign was present in 74.5% of the cases. The proprioceptive deficit was evident by only using the walking Romberg in 21 out of 38 patients that had a positive Romberg sign. Though not statistically significant, the mean 30 metre walking times were slower in patients with standing Romberg test than in those with positive walking Romberg test and fastest in those with neither of these tests positive. The combination of either Hoffman’s reflex and/or Walking Romberg was positive in 96% of patients.

Conclusion: The walking Romberg sign is more useful than the standing Romberg test as it shows evidence of a proprioceptive gait deficit in significantly more patients with cervical myelopathy than is found on conventional neurological examination. The combination of Hoffman’s reflex and walking Romberg sign has a potential as useful screening tests to detect clinically significant cervical myelopathy.

Ethics approval: none

Interest statement: none


I Siddique M Khatri H Norris R Ross

Aim: To analyse the impact of implant position in the outcome of Charite III Disc Replacement implants.

Methodology: 160 Charite III Lumbar Disc Replacements that were implanted between 1990 and 2000. The average age was 46 years with 62 Males and 98 Female subjects. An independent observer (HN) administered Pain score (VAS 1–10) for Low Back Pain (LBP) and Oswestry Disability Index (ODI). These clinical outcome parameters were compared with coronal and sagittal position of the implants from the latest available radiographs. Those with operation at L3L4 (small numbers = 20) and inadequate radiographs were excluded.

Results: 48 implants were optimally placed and 70 implants were placed sub optimally. Both the groups were in similar age groups (45.02 years, SD 7.61 and 48.31 years, SD 8.04). Clinical: No statistical or clinically significant difference was observed in LBP on VAS (4.92 V/S 4.41), ODI (42.8 V/S 38.0) and in Patient Satisfaction at an average follow up of 70 months. Movements: Average movement at optimally placed discs at L4L5 was 4.4o(95% CI 2.3–6.7) and at L5S1 was 5.9o(95% CI4.2–7.5) and at sub optimally placed disc at L4L5 was 3.8o(95% CI 2.4–5.1) and at L5S1 was 3.8o(95%CI 2.3–5.3).

Conclusions: Clinical and radiological results after Charite III Disc Replacement is NOT dependent on positioning of implants.

Ethics approval: None

Interest Statement: None


T Okoro B Sell P Sell

Purpose: Self reported walking distance is a clinically relevant measure of function, our aim was to report patient accuracy and understand factors that might influence perceived walking distance.

Method: A prospective cohort study. 103 patients were asked to perform one test of distance estimation and 2 tests of functional distance perception using pre-measured landmarks. Standard spine specific outcomes included the patient reported claudication distance, Oswestry disability index (ODI), Low Back Outcome Score (LBOS), visual analogue score (VAS) for leg and back, and other measures.

Results: There are over-estimators and under-estimators. Overall the accuracy to within 10 yards was only 5% for distance estimation and 40% for the two tests of functional distance perception. Distance: Actual distance 121.4 yds; mean response 268yds (95% CI 192.8–344.15), Functional test 1 actual distance 32 yards; mean response 78.4 yds (95% CI 58.6–97.3) Functional test 2 actual distance 21.4yds; mean response 51.9yds (95% CI 38.3–65.5). Surprisingly patients over 60 years of age (n=43) are twice as accurate with each test performed compared to those under 60 (n=60) (average 70% overestimation compared to 140%; p=0.06). Patients in social class I (n=18) were more accurate than those in classes II–V (n= 85): There was a positive correlation between poor accuracy and increasing MZD (Pearson’s correlation coefficient 0.250; p=0.012). ODI, LBOS and other parameters measured showed no correlation.

Conclusions: Subjective distance perception and estimation is poor in this population. Patients over 60 and those with a professional background are more accurate.

Ethics approval: not required

Interest Statement: none


I Siddique M Hakimi Z Javed R Smith M Khatri

Introduction: Current evidence on the indications for and efficacy of non-rigid lumbar stabilisation remains unclear. The aim of this study was to review the results of this system in thirty four patients who underwent this procedure between 2002 and 2006.

Methods & Results: Validated outcome measures including Visual Analog Score (VAS), Roland Morris Disability Questionnaire (RMDQ), Modified Zung Score and Modified Somatic Perception Questionnaire (MSPQ) were evaluated preoperatively and at 1 year post operatively. Subjective patient outcome (much better, better, same, worse) was assessed at final followup Kaplan-Meier Survival analysis was performed using need for revision surgery as endpoint. The indications for surgery in thirty patients was radicular pain and back pain, these patients underwent discectomy (12 patients) or decompression (18 patients) in addition to Dynesys. Two patients who had only back pain underwent Dynesys alone. There were statistically significant improvements in VAS, RMDQ, Modified Zung and MSPQ scores at 1 year. However at final followup 46% of patients had a unsatisfactory subjective patient outcome (worse or the same). 25% of patients required revision surgery (posterolateral fusion) for ongoing pain (seven patients) or infection (one patient).

Conclusion: We recommend that all patients undergoing this procedure are counselled regarding the high rate of revision surgery and patient dissatisfaction. Routine use of this implant should be subject to the findings of larger studies and randomised controlled trials.

Ethics approval: None

Interest Statement: None


JCD Leach RG Bittar

Purpose of the study: To determine the safety of the use of bone morphogenetic protein-7 (BMP-7) in anterior cervical surgery

Methods and results: A prospective consecutive cohort of 132 patients underwent anterior cervical discectomy and fusion using interbody cages. In 123 of these patients BMP-7 was also used. The dose of BMP-7 was controlled (one half to one unit; 1.75–3.5 mg BMP-7 & 0.5–1.0 gm collagen) and contained (no BMP-7 was placed outside the cage).

The primary outcome measure was the presence of clinical adverse events during the first 30 days. The secondary outcome was the extent of radiological soft tissue swelling at the C6 level as measured on plain radiographs in the early post-operative period and compared to a historical post-operative anterior cervical fusion cohort.

There was no mortality and no re-operation in this series. 2.4% of patients experienced complications: transient brachalgia (1/123), persistent dysphagia (1/123), sudden dysphagia and dysphonia (1/123).

Mean pre-vertebral soft-tissue measurement in 20 patients from the BMP-7 group was 20.9 mm (16–27 mm). This compared with 18.7 mm (15–25 mm) in 7 patients from the non-BMP-7 group, and 18 mm in the historical control group.

Conclusions: BMP-7 can be used safely in anterior cervical fusion surgery. A slight increase in post-operative pre-vertebral swelling was not clinically significant. The effect of BMP-7 on the rate and timing of fusion, as well as clinical outcome, is yet to be elucidated.

Ethics approval: None-audit

Interest Statement: None


Full Access
NS Harshavardhana J Hegarty BJC Freeman BM Boszczyk HV Dabke J Weston A Race

Purpose: To review the existing practice of coding in spinal surgery and ascertain its accuracy for surgical procedures, co-morbidities and complications.

Methods: A retrospective review of 70 cervical and 100 lumbar consecutive spinal surgeries performed since April 2006 was conducted. The clinical coding data and hospital notes were reviewed.

Results: Coding data of 5 cervical spine surgeries were not available. Of the 165 cases, the accuracy of primary procedural codes was 93.9% (90.8% cervical & 96% lumbar). This reduced to 77.6% (75.4% cervical & 79% lumbar) when the accuracy for entire description of performed surgery was considered. Medical co-morbidities were coded appropriately in 64.2% of the patients (55% cervical & 70% lumbar). The procedural codes did not specifically reflect the surgery performed and lacked reproducibility. Surgical levels were coded incorrectly in 9% of the cases. Cervical surgeries were coded as lumbar in 4 and posterior surgery as anterior in 3 cases respectively. The commonly missed co-morbidities were drug allergies, hypercholesterolemia, smoking and alcoholism. Post-op adverse events were coded in 75% of the cases (16/20 cervical & 5/8 lumbar). The accuracy was better for lumbar as compared to cervical spinal surgeries.

Conclusion: Coding is a universal language of communication and its accuracy is important not just for PbR, but for data quality, audit and research purposes too. The financial implications regarding PbR governed by HRG codes (dictated by OPCS 4.4 & ICD–10 codes) are discussed. Following this study, a clinical coding facilitation form has been introduced to improve data quality.

Ethics approval: None

Interest statement: None


HV Dabke JH Kuiper C Mauffrey JM Trivedi

Introduction: Spinous process osteotomy (SPO) and multiple laminotomy can be used for multi-level lumbar decompression. We conducted an experimental study to compare the effects of these two methods on spinal kinetics.

Method: Ten fresh calf spines (L2- sacrum) were mounted in dental stone and segmental motion of L3 relative to L5 was assessed using an electromagnetic 3-D motion detection system (FASTRAK, Polhemus, Colchester, VT, USA). Pure moments of 0, 2.5, 5, 7, and 10 Nm were used in flexion/extension, right/left lateral bending, and right/left axial rotation. The moments were generated by applying two equal and opposite forces (weights) to the perimeter of a plastic circular disc, which was fixed to the superior end plate of L3 by three screws. In five spines decompression was performed at L3/4 and 4/5 using standard laminotomy technique. Decompression using SPO was done at L3–5 through a unilateral approach in the rest. Segmental mobility between the two methods was compared using the Mann-Whitney test.

Results: Mean range of motion in the specimens before intervention was-lateral bending (32.70 ± 7.6 SD), rotation (13.10 ± 4.8 SD), flexion/extension (19.30 ± 7.1 SD). There was statistically significant difference between mean increase in lateral bending after SPO to that following laminotomy (4.00 ± 1.5 SD vs 0.60 ± 1.6 SD; p=0.008). Mean increase in flexion- extension after SPO was not significantly different from that after laminotomy (4.50 ± 1.1 SD vs 3.90 ± 3.8 SD; p= 0.75). There was no difference in the mean increase in axial rotation after SPO compared to that following laminotomy (7.90 ± 3.6 SD vs 6.80 ± 5.0 SD; p= 0.75).

Conclusions: Both laminotomy and SPO produced increased range of motion in a calf spine model. SPO produced significant increase in lateral bending although its clinical significance is unknown.

Ethics approval: none

Interest Statement: Local grant (Research Fund, Centre for Spinal Studies, Robert Jones and Agnes Hunt Hospital, UK


NM Orpen T Barton R Ahmad I Nelson J Hutchinson

Spinal lipomatosis is seldom reported in spinal literature and although the condition occurs commonly, we seldom recognise it in reviewing spinal MRI scans. We aim to highlight the condition and show MRI signs to allow easier recognition. We also introduce a new method of evaluation of the severity of the condition using T1 MRI axial views to evaluate the area of the spinal canal involved in the pathological process.

We have evaluated 30 patients with a diagnosis of spinal lipomatosis made on sagittal MRI scanning of the spine. The T1 and T2 axial images have been evaluated using standard digital software which allows calculation of the surface area occupied by fat and allows representation of this as a ratio to total canal diameter. This has then been correlated to the traditional method of classifying lipomatosis on sagittal MRI sequences.

We have found this method useful and believe it provides a more accurate representation of how fat in the canal may produce symptoms of nerve compression. This shows that the condition behaves more like our traditional understanding of spinal stenosis with symptoms more likely when the relationship of fat to canal reaches greater than 50%. This approach to spinal lipomatosis has not been described before but we feel produces a better understanding of the condition than we have had before by using a classification based on purely on sagittal MRI sequences.

Ethics approval: None Audit

Interest Statement: No conflict of interest


F Dakhil-Jerew JAN Shepperd

Introduction: In this study we have studied the range of motion within Dynesys treated discs and levels adjacent to flexible stabilisation.

Dynesys was designed to offer physiological motion at the lumbar spine. An advantage which is superior to abolishing movements through spinal fusion.

Methods: A cohort of 75 post-Dynesys patients had weight-bearing lateral lumbar spine x rays in flexion/extension positions. Evaluation was done through PACS™ digital software. Flexibility at individual disc level was measured as the differences between flexion/extension angles accurate to within 1°. Motion was evaluated at the index and immediate adjacent levels.

Results: Patients with single level Dynesys had an average ROM of (3+/−4.7) at L5-S1 and (5.1+/−2.9) at the immediate adjacent level. Two levels Dynesys was associated with a ROM of 5+/−3.6 at L5-S1 & L4–5 and 3.5+/−1.8 at their immediate neighbour disc. Across three levels, Dynesys favoured a ROM of 5.3+/−2.5 at the operated sites and 1.6+/− 2 at the adjacent level.

Discussion & Conclusion: This study is the first radiological research to confirm the flexibility of Dynesys. Controlled motion at the dynesys treated disc levels share to distribute global spinal movements. This will advantage the next disc segments and protects them from risk of developing “accelerated adjacent segment disease”.


P Kempshall P Jemmett S Evans P Davies DA Jones J Howes S Ahuja

This study aims to evaluate the accuracy of sheer off self limiting screw drivers and to assess repeatability with age.

It has been reported that overzealous tightening of halo pins is associated with co-morbidity. Our unit has recently received a tertiary referral where the patient over tightened a pin leading to intracranial haematoma, hence our interest in this subject. The torque produced by six new and nine old screw drivers was tested using an Avery Torque Gauge and a Picotech data recorder. These devices are designed to produce a torque of 0.68 Nm, any greater than this is potentially hazardous. Accepted error for each device was +/− 10%. The average torque produced by the new screw drivers was 0.56 Nm with a range of 0.35–0.64 Nm (SD 0.120). The older screw drivers produced an average torque of 0.67 Nm ranging from 0.52–0.85 Nm (SD 0.123).

In conclusion, sheer off self limiting screw drivers are not accurate devices. The older devices are more likely to produce a torque exceeding a safe range and therefore we would recommend the use of new devices only.

Ethics approval: none audit.

Interest statement: none local grant.


S Ramakrishna S Ahuja

Introduction: Spinal surgical procedures are associated with significant morbidity. It is vital the patients are aware of the potential complications and the implications. The General Medical Council published guidelines regarding consent in June 2008.

Aim: To examine the adequacy for consenting for spinal surgical procedures and focussing on documentation of serious risks.

Methods: Case notes of seventy consecutive patients who had undergone spinal surgery were retrospectively reviewed. The consent forms were examined for documented procedures, complications, grade of the consenting member and timing of the consent.

Results: The documented procedure on the consent form and the operation sheet matched in all seventy cases (100%). Consent was taken by the consultant in 50% of the patients, 30% were consented by middle grade doctors and 20% were consented by the junior doctor. The consenting person was present at the procedure in 63% of the cases. Sixty percent (60%) of the patients were consented in the pre-admission clinic, 23% were consented on the day before the procedure and 17% were consented on the day of the procedure. Common and serious complications such as infection (84%), bleeding (76%), pain (67%), bladder and bowel problems (84%), paralysis (70%) and nerve root damage (67%) were clearly documented.

Conclusion: Two-thirds of the patients are given adequate information to obtain informed consent in the pre-admission clinic. Majority of the patients are aware of the common and the serious risks associated prior to the procedure.

Interests: None

Ethics approval: None


H Sharma R Reid AT Reece

Introduction: Giant cell tumours are locally highly aggressive and extremely unpredictable bone tumours. Treatment of spinal GCTs remains controversial. We report our experience of 11 Giant cell tumours of the spine identified from the Scottish Bone Tumour Registry.

Materials and Methods: Details of 11 cases of histologically confirmed Giant cell tumours of the spine (9 benign and 2 malignant) between 1960 and 2004, were extracted from the Scottish Bone Tumour Registry. The casenotes and radiographs were retrospectively reviewed.

Results: There was a slight feminine predominance of 7 cases. Mean age was 34 years (range, 16 to 61 years). The sacrum (5) was most common location, followed by lumbar (3), thoracic (2) and rarely in cervical (1). Operative intervention was carried out in 5 (curettage-1; excision-5). Three also received supplemented bone grafts. Radiotherapy (including some of the operative cases) was administered in 9 patients. There were 5 recurrences (45.4%). There were 7 survivors 2 of whom still had evidence of persistent primary disease. Two died with unrelated illnesses and two from local recurrences.

Conclusions: Axial GCTs behave aggressively with a high recurrence rate (45%). Radiotherapy is useful in the management of GCTs of the spine and conservative surgery with local radiotherapy is a viable treatment option in some selected patients.


SR Hadgaonkar A Kasis G. Reddy C. Bhatia M. Hernandez M. Krishna T. Friesem

Purpose: To assess the outcomes in consecutive 32 patients of two level cervical disc replacement

Methods: In this article, we report 2-year results of anterior cervical decompression and two level cervical disc replacements (prestige) in 32 patients with a diagnosis of symptomatic cervical spondylosis. Dynamic assessment with lateral radiographs of the cervical spine in flexion/extension was done pre and post op. All of them had partial uni/bilateral uncinectomy, which adds in lateral bending. The median age of all patients was 46 years (range 32–61). Levels of surgery included between seven C3–C7, most common were C5–6, C6–7.

Results: Neck and arm pain as well as disability scores (VAS, ODI and SF36) were significantly improved by 3 months and remained improved at 2 years. Radiography revealed the complete motion (From flexion to extension) at upper disc replacement level of 11% and 9.6% at the lower level. There is a significant decrease of the facet joint articulation overlap in the sagittal plane. As the diameter of socket is slightly larger than the ball in prestige disc replacement, it helps in additional axial movement. There was reduction in motion at the adjacent segments above and below, preventing adjacent segment problems.

Conclusion: Twenty-four months after surgery, patients who underwent two level cervical disc replacements demonstrated greater improvement in neurologic function and neck pain. It helps in restoring sagittal balance, functional outcome of patient because of increased lateral bending, axial rotations and flexion-extension.

Ethics approval: done from appropriate authorities

Interest Statement: There is no local grant, national grant, commercial/industry support for this article. There are no interest or gain from any source for this article.


KT Tsang JC Hobart TJ Germon

Aim: To investigate the incidence of headache and facial pain in patients with neck pain and/or brachalgia and determine any potentially causal relationship.

Methods & Results: Sequential patients referred to the spinal clinic for assessment of their cervical spine were asked to shade on pain drawings, the distribution of pain and sensory disturbance which they were experiencing.

The distribution of shading was categorised as head pain (subdivided into face, vertex and occiput) and arm pain. The incidence of head pain and its distribution was analysed along with its relationship to arm pain.

Data collected from patients presenting with thoracolumbar pain over the same period was used as a control.

Of 200 patients presenting to the clinic with cervical problems, 58 had head pain. 50 had occipital pain, 28 had vertex pain and 8 had facial pain. None of the thoracolumbar patients had head pain although 12 had upper limb pain.

Of the 26 cervical patients who had unilateral arm pain & head pain, the head and arm pain were always on the same side.

Conclusion: Head & facial pain in association with neck pain and brachalgia is common. The homolaterality of symptoms suggest the potential for causal relationships hitherto unrecognised in the literature. It is possible that some patients given medical diagnoses for their headache (e.g. migraine) might have surgically treatable cervical pathology. Clearly, further investigation to elucidate this potential relationship is required.


J McRoberts MJLP Porteous

Introduction. A redesign of a joint replacement service to increase throughput and reduce length of stay despite a reduction in junior doctors hours, recognised that Orthopaedic Nurse Practitioners (ONP) based on the US Surgeons’ +

+ Assistant model would play a pivotal role in managing patient flow efficiently.

Redesigning the Service. The ONP has input at every step of the patient journey. In Outpatient Clinic they see follow-up and selected new patients, commencing the informed consent process if appropriate. They run an information program to patients awaiting surgery, are involved in Pre-Admission clinic, assist in theatre and oversee post-operative care monitoring progress, ensuring earliest possible safe discharge and prescribing as necessary. Continual Audit, Research and development to improve the service are part of the role.

Outcomes. The impact of the introduction of the role after 4 years together with service redesign has been:

An increase in the number of new referrals seen in OPD by 50% from 8 to 12 per clinic.

An increase in the volume of hip & knee replacements from 490 in 2003 to 834 in 2007.

Increased theatre efficiency with routinely 2 joints per session.

A reduction in length of stay from mean of 10.75 days in 2003 to 6.89 days in 2007.

Continuous monitoring of post-operative infections with current cumulative rate of 0.71%.

Improved patient satisfaction as measured by patient feedback sessions.

Conclusion. Based on the US Surgeons’ Assistant model, with involvement at every step of the patient journey, ONPs have been the most important single element in the redesign of the joint replacement service to meet a massive increase in demand. Further ONPs are being recruited to fill the gap envisaged by a reduction in junior doctors hours as a result of the European Working Time Directive.


W Dandachli S Ulislam M Liu R Richards JD Witt

Introduction: The diagnosis of acetabular retroversion has traditionally been established by the presence of a cross-over sign on a plain pelvic radiograph. This however can be greatly influenced by the radiograph’s quality and degree of pelvic tilt. The aim of this study was to look at the relationship between cross-over and true anatomical version as measured in relation to an anatomical reference plane. The secondary aim was to determine whether in true retroversion there was excess coverage of the femoral head anteriorly.

Materials and Methods: Radiographs of 33 patients (64 hips) being investigated for symptoms of femoro-acetabular impingement were analysed. The presence of a cross-over sign was documented and the extent of cross-over was measured by noting the point on the rim where the cross-over occurs. CT scans of the same hips were analysed to determine anatomical version, and to calculate total, anterior and posterior coverage of the femoral head. This was done in relation to the anterior pelvic plane after correcting for pelvic tilt.

Results: The sensitivity, specificity and positive and negative predictive values for the cross-over sign were 92%, 55%, 59% and 91% respectively. The cross-over distance was correlated with 3D version (p=0.01). There was no significant difference in total cover of the femoral head between the anteverted and retroverted subgroups (71% vs. 72% respectively; p=0.55). Anterior cover was higher in the retroverted subgroup (35% vs. 32%; p = 0.0001), and posterior cover was significantly lower in this subgroup (37% vs. 39%; p = 0.002).

Discussion: Although the cross-over sign was sensitive enough to identify 92% of the retroverted cases, its specificity was low with just under half of the anteverted cases being labelled as retroverted. The findings for femoral head cover suggest that retroversion is characterised by posterior deficiency and increased cover anteriorly.


A Sahu N Jain S Dalal BD Todd

Aim: Our aim was to find the effect of implementation of European working time directive (EWTD) on current Orthopaedic training in England. Hip fracture surgery is one of the most frequently performed operation on the trauma lists and hence it is considered mandatory to independently able to perform hip fracture surgery in the registrar training curriculum.

Methods: This reaudit was performed over four month period in 2007 (1st April to 31st July) collating information on 1010 hip fracture patients undergoing surgery in 14 NHS hospitals in the North Western deanery of England.

Results: An orthopaedic trainee of registrar level (Speciality trainee year 3–6) was the lead surgeon in 37% of cases while only 4% of operations were performed by a Speciality trainee year 1–2 or Foundation year 2 (senior house officer grade) in 2007. These findings varied amongst the audited hospitals but in one hospital, trainees operated on only 12% of hip fractures. In previous audits done in 2003 and 2005, Orthopaedic registrar’s operated on 52 % and 50% of hip fractures respectively. Similarily senior house officers had hands on experience on 11% and 9% of hip fractures in 2003 and 2005 respectively.

Discussion: European working time directive has reduced the working hours, leading to decreased hours of surgical training. The Orthopaedic Competence Assessment Project (OCAP) and the Intercollegiate Surgical Curriculum Project (ISCP) expects trainees to achieve core competencies in key procedures such as hip fracture surgery. In the context of shorter training and reduced working hours, to achieve these core competencies it is imperative to maximise operative exposure and experience for trainees. If the findings of this reaudit in Northwest of England are mirrored elsewhere in United Kingdom, the implications for orthopaedic training are significant.


D. P. Hall D. Srikantharajah R.E. Anakwe P. Gaston C.R. Howie

Introduction: Patient-reported outcome and satisfaction scores have become increasingly important in evaluating successful surgery. There is continued enthusiasm for metal-on-metal resurfacing of the hip, particularly as an alternative to total hip replacement (THR) in young, active patients with osteoarthritis. However, although mid-term survivorship data is promising, it remains unclear whether patient-reported outcomes following resurfacing match those following THR.

Patients and Methods: This case-matched control study compared patient-reported outcome and satisfaction data following hip resurfacing and total hip arthroplasty. Thirty-three consecutive patients selected for hip resurfacing were compared with 99 patients undergoing cemented total hip replacement (THR), matched for age, sex and pathology. Participants completed a Short-Form 12 Health Survey (SF-12) and Oxford Hip Score (OHS) questionnaire pre-operatively and 6 months post operatively, with an additional patient satisfaction questionnaire.

Results: There was no difference in length of hospital stay. Both groups reported improved outcome scores, with mean OHS improvements of 19.5 (95% CI: 17.0–22.1), and 20.6 (95% CI: 18.6–22.5) following resurfacing and THR respectively. There were similar improvements in SF-12 PCS of 14.2 (95% CI: 9.5 to 14.2) and 15.2 (95% CI: 13.2 to 18.2) for the resurfacing and THR groups respectively. The improvement in outcome scores did not differ between the two groups on multivariate regression analysis (P=0.509 for OHS, P=0.629 for SF-12 PCS). Both groups reported high levels of satisfaction, which tended to be better in patients undergoing hip resurfacing (97.0% vs 92.9%), with resurfacing patients reporting better pain relief (P=0.022) and better heavy lifting (P=0.038) at 6 months.

Discussion: This study shows that the short-term patient-centred outcome scores for hip resurfacing are at least as good as for conventional hip replacement, with slightly higher levels of satisfaction.


T. Kamal S. Garg Z. Win

Introduction: Patients presenting with fracture of the femoral neck are usually elderly, and often have extensive co-morbidity. Patients who are considered too unwell for surgery are often keep being delayed until assumed optimised or treated non-operatively. These patients have a high morbidity and mortality and present significant nursing difficulties.

Materials and Methods: We describe a technique of fixation of fracture of the femoral neck under direct infiltration local anaesthesia; that can be performed on the sick elderly patient without the risks associated with general or regional anaesthesia. In a series of twenty eight patients all diagnosed with serious co-morbidity (ASA4) on pre-operative assessment. Twenty three patients suffered from extracapsular fracture neck of femur and five intracapsular fracture neck of femur. All patients were informed about the risks of anesthesia by the senior anesthetist prior to surgery. A mixture of 20 mls n.saline + 20mls of 1% lignocaine with 1:200,000 adrenaline + 20mls 0f.25% plain marcaine (total 60 mls used). This can be increased up to 140 mls in the same ratios.

Results: All patients were operated by various grade registrars. Twenty four (24) DHS and four Hemiarthro-plasty were performed. The patients were all able to complete the surgery using this technique; none required conversion to another form of anaesthesia.

The average duration of surgery was 44 min. All patients survived the procedure and until discharge form hospital.

Discussion: Finlayson and Underhill (1988) suggested that extracapsular fractures are supplied predominantly by the femoral nerve and are therefore more amenable to this type of treatment.

We recommend the consideration of this technique for management of patients with severe co-morbidity and fracture of the femoral neck in order to optimise their chance of survival and avoid the morbidity associated with bed rest.


SS Madan M Leunig R Ganz

Introduction: Patients who develop proximal femoral growth arrest present a typical deformity of short femoral neck, high riding greater trochanter, and caput valgum. This is seen usually seen in Perthes, AVN due to treatment of CDH, and sometimes in epiphyseal dysplasia.

Method: We present a series of 34 cases (34 hips) treated at the above institutes. The cases treated in Berne were prior to 2002. Twenty patients were females. There were 24 patients with Perthes, nine with old healed and treated DDH, and one with epipyhseal dysplasia. All had Trendelenburg or delayed Trendelenburg sign. They had an average shortening of 3.5 cms, and their age range was 14 yrs to 64 yrs. Pre-op assessement was done with plain radiographs, CT scan, and or MRI scan.

Results: Their Merle D’Aubigne score improved from 13 (10 to 15) to 17 (15 to 18) at the latest follow up. Twenty four (70%) had good to excellent result. Five have since undergone a total hip replacement, and five have some pain but can do reasonable amount of activity. The follow-up is 6 years (2 to 13 years). There was one trochanteric non-union, but no cases of AVN.

Discussion: We describe the technique of biomechanically improving the moment arm and muscle length with this procedure. This helps the soft tissues to strengthen, improve force vectors in the correct direct in the hip, perhaps improve the longevity of the joint and also prepare the hip soft tissues for future THR.


TCB Pollard RN Villar M Willams MR Norton ED Fern DW Murray AJ Carr

Introduction: Femoroacetabular impingement (FAI) causes pain in young adults and osteoarthritis. Genetic factors are important in the aetiology of osteoarthritis. We aimed to investigate the extent to which FAI has an underlying genetic basis, by studying the siblings of patients undergoing surgery for FAI and comparing them with controls.

Methods: 66 patients (probands, 29 male, 37 female, mean age 39.1 years) treated surgically for FAI provided siblings for the study. Probands were classified as having cam, pincer or mixed FAI. 101 siblings (55 male, 56 female, mean age 38.2 years) were recruited. The control group consisted of their 77 partners and was age and gender-matched. All subjects were assessed clinically and radiologically (standardised AP Pelvic and cross-table lateral radiographs of each hip). Radiographs were scored for the presence of osteoarthritis, and morphological abnormalities.

Participants were classified as:

Normal morphology, no clinical features

Abnormal morphology, no clinical features

Abnormal morphology, clinical signs but no symptoms

Abnormal morphology with symptoms and signs

Osteoarthritis.

Results: The sibling relative risks were significant for groups b, c, and d (ranging between 2–5, p< 0.01). Pro-bands and siblings shared the same pattern of abnormal morphology. Gender specificity was apparent: pincer abnormalities common in sisters but not in brothers. The brothers of probands with cam deformities almost universally demonstrated the same deformity, but only 50% of sisters did.

Discussion: Genetic influences are important in the aetiology of FAI. Whether the morphological abnormality is determined at conception or by an inherited predisposition to an acquired event during development warrants further study. Symptoms are variable, indicating a spectrum of disease progression. These cohorts present an opportunity to prospectively study the natural history of the condition, improve understanding of the mechanisms and pathology, and potentially to be recruited into clinical trials.


V Khanduja K Sisak RN Villar

Aim: The aim of this study was to assess the role of Hip Arthroscopy in the patient with a symptomatic Resurfacing arthroplasty of the hip.

Patients and Methods: Twelve consecutive patients who presented to our clinic with a painful resurfacing and indeterminate or normal investigations underwent an arthroscopy of their resurfacing were prospectively enrolled into the study following appropriate consent. The pre-operative investigations included haematological indices and acute phase reactants to rule out infection along with plain radiographs and an isotope bone scan.

Results: (table deleted)

Conclusions: Assessment of a symptomatic resurfacing is usually difficult and becomes more challenging in the background of normal or indeterminate investigations. However, in this situation, we found that in experienced hands, hip arthroscopy can be utilised as an effective tool for aiding diagnosis and offering therapeutic interventions in these patients.


TCB Pollard EG McNally DC Wilson B Maedler DR Wilson M Watson AJ Carr

Introduction: Subtle deformity of the hip joint may cause osteoarthritis. In femoroacetabular impingement (FAI), cam deformities damage acetabular cartilage. Whether surgical removal of cam lesions halts progression is unknown. Sensitive, non-invasive assays of chondral damage are required to evaluate early treatment efficacy.

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) permits inference of glycosaminoglycan (GAG) distribution. We aimed to determine whether hips with cam deformities have altered GAG content, using dGEMRIC.

Methods: Subjects were recruited from a prospective cohort study. All were clinically and radiographically assessed. Hips with a normal joint space width (> 2.5mm) were eligible for dGEMRIC. 32 Hips (18 male, 14 female, mean age 51.7 years, none of whom had been investigated for hip pain) with (n=21) and without (n=11) cam deformities were scanned.

2 regions of interest (ROI) were studied:

acetabular cartilage from 12 to 3 O’Clock (T1-Index-acet).

total cartilage (femoral and acetabular) for the joint from 9 to 3 O’Clock (T1-Indextotal).

The average of all pixels within the given ROI defined the T1-index.

For each hip, the ratio of the GAG content T1-Index-acet/T1-Indextotal was calculated. Mean T1-Indexto-tal and T1-Indexacet/T1-Indextotal were compared.

Results: T1-Indextotal were similar (689ms v 700ms, p=0.79) but T1-Indexacet/T1-Indextotal was lower in cam hips (0.93 v 1.01, p=0.017), indicating localised depletion of GAG content. Cam hips with positive clinical signs had lower T1-Indextotal than cam hips without (629ms v 717ms, p=0.055), and non-cam hips (629ms v 722ms, p=0.049).

Discussion: Cam hips have lower GAG content of their anterosuperior acetabular cartilage. dGEMRIC identified more generalised disease in cases with positive clinical findings. Ratios of GAG content for specific ROIs enable mapping of chondral damage. This may aid understanding of early disease mechanisms, track progression, and facilitate assessment of the efficacy of surgical procedures.


AS Desai TN Board A Karva B Derbyshire ML Porter

Introduction: The clinical results of the modular Charnley Elite total hip system have been the subject of some interest in recent years. Some studies have shown significant subsidence and rotational instability in stems when used with low-viscosity cement. These unstable stems have been shown to fail early. The purpose of this study is to demonstrate our conflicting clinical results.

Materials and Methods: 616 modular Charnley Elite total hip arthroplasties were inserted between 1995 and 2002 at Wrightington Hospital, which is a tertiary referral centre and centre of excellence for joint replacement in United Kingdom. Both Consultants and trainees performed operations and a variety of surgical approaches were used. Normal viscosity bone cement was used in all patients. All patients were followed up prospectively.

Results: At mean follow-up of 8 years (range 5–12), 471 hips were available for review. 87 patients had died and 12 were lost to follow-up. 2.7% (13 cases) of femoral components and 2.9% (14 cases) of acetabular components had been revised for aseptic loosening. 10 hips (2.1%) underwent revision for deep infection and 2 (0.04%) for recurrent dislocation. The overall survival with aseptic loosening as an end point was 97% and for revision for any reason was 94.5%.

Conclusion: Our results show acceptable clinical survivor-ship for this implant when used with standard viscosity cement. This contrasts with the lower survivorship rates published by other centres. Our result should reassure patients and surgeons alike that this prosthesis can be associated with acceptable results in the medium term.


A Augustine D Macdonald H M Murray A Mohammed RMD Meek S Patil

Introduction: Infection following hip arthroplasty although uncommon can have devastating outcomes. Obesity, defined as a BMI of ≥ 30, is a known risk factor for infection in this population. Coagulase negative Staph Aureus (CNS) is the commonest causative organism isolated from infected arthroplasties. This study was performed to determine if there has been a change in the causative organisms isolated from infected hip arthroplasties and to see if there is a difference in obese patients.

Methods: Data on all deep infection following primary and revision hips was obtained from the surgical site infection register from April 1998 to November 2007. All case notes were reviewed retrospectively.

Results: There were 49 patients with 51 infected arthroplasties; 25 infected Primary THAs and 26 infected Revision THAs. We found a female preponderance in the infected primary and revision THAs (n=30). 65.3% of all patients had a BMI of ≥ 30. Over the period studied, Coagulase negative Staph was the most common organism isolated (56.8%) followed by mixed organisms (37.2%) and Staph Aureus (25.4%). Multiple organisms were found exclusively in obese patients. In more than half of cases the causative organisms were resistant to ≥ 2 antibiotics.

Discussion: This study shows that over the last 10 years, CNS continues to be the most frequently isolated organism in infected hip arthroplasties. Multiple organisms with multiple antibiotic resistances are common in obese patients. On this basis we recommend that combination antibiotic therapy should be considered in obese patients.


X. Flecher O. Pearce S. Parratte D. Grisoli M. Helix JM. Aubaniac JN. Argenson

Introduction and Method: For 16 years, now, we have been using custom made femoral stems (titanium stem, HA coated) based on preoperative patient CT scans in young patients presenting with symptomatic osteoarthritis of the hip. The aim was to provide optimum initial fit-and-fill of the stem in the femoral medullary canal, conferring the best chance of secondary osteoin-tegration. This, with a goal of long term survivorship. The custom stem also enables dialling-in correction of the (often abnormal) femoral neck version (in young patients presenting with arthritis) to a more normalised 15 degrees of anteversion.

Results: We present the long term results (5–16 year, mean of 10 years), clinical, survivorship and radiological, of 312 primary total hip arthroplasties in 280 patients, all of whom were under the age of 50 years of age (mean age 40).

At 10 years we have a survivorship, if femoral aseptic loosening is used as an end point, of 97.6%. There was a deep infection rate of 1.2%, and a dislocation rate of 1.9%. There were no cases of thigh pain, and no intra-operative femoral neck/shaft fractures.

Discussion: The under 50’s with hip arthritis requiring total hip arthroplasty are a highly challenging group, they are young, active and tend to have distorted anatomy. Our results are superior to those previously published using either cemented or standard uncemented stems. Thus, justifying the increased initial financial outlay on the custom-made stem.


I Gill A Malviya M Reed

Aim: To assess the infection rate following Primary Lower Limb Arthroplasty using single dose gentamicin antibiotic prophylaxis compared to a traditional three doses of cephalosporin.

Material And Methods: All patients undergoing primary Total Hip and Knee joint replacements over 6 months (October 2007 to March 2008) at 3 participating hospitals were prospectively followed up to assess perioperative infection rates. Joint replacements were defined as having infection by the UK Health Protection Agency Surgical Site Surveillance (SSI) criteria. All patients received single dose antibiotic prophylaxis using intravenous Gentamicin 4.5mg/kg body weight adjusted for body mass index.

This group of patients were compared with previous data collected over a 6 month period (Jan to Mar 2007 and Oct to Dec 2005) from the same hospitals for infection rates in Lower Limb Arthroplasty using 3 doses of Cefuroxime 750mg as antibiotic prophylaxis.

Return to theatre data was collected independently after introduction of gentamicin to compare with previous data.

Results: 408 patients underwent Total Hip Replacements (THR) and 458 patients underwent Total Knee Replacements (TKR) during the study period. This was compared with 414 patients who underwent THR and 421 patients who underwent TKR during a 6 month period over 2 years.

Surgical site infection was detected in 9 THRs (2.2%) and 2 TKRs (0.44%) in the study group as compared to infection in 13 THRs (3.1%) and 12 TKRs (2.9%) in the control group.

Using the Fisher Exact test the infection rates in THRs were not significantly different between the 2 groups (p value – 0.52) but the infection rates were significantly reduced in the study group for TKRs (p value – 0.005).

There were no complications with the use of Gentamicin as antibiotic prophylaxis.

The return to theatre was 2.42% (28/1157) after introduction of Gentamicin as compared with 1.85% (37/2005) [p value – 0.172] before this. This was a cause for concern, although not a significant difference.

Cefuroxime is known to promote Clostridium difficile infection and was removed from the hospital pharmacy to help meet a UK government targets to reduce the incidence. The rate of Clostridium difficile infection was reduced within the hospital with the use of single dose antibiotic prophylaxis although other measures to reduce its incidence were also introduced.

Conclusions: This study shows that the use of single dose antibiotic prophylaxis using Gentamicin is effective in preventing SSI as defined in the HPA definition. It is safe to use and reduces rate of Clostridium difficile associated diarrhoea.

However, be wary of increased rate of return to theatre following use of gentamicin.

Further period of evaluation and study is needed before it is recommended for routine use in present or modified form.


M Rookmoneea M Maru IW Wallace

Introduction: REEF™ is a modular distal locking implant, indicated for use in extensive loosening of femoral stems, peri-prosthetic hip fractures, and tumour surgery requiring distal anchorage to allow resection of the femur proximally. Very little experience with the REEF™ has been reported.

Objective: We report on a single surgeon series of 16 patients who underwent femoral reconstruction using the REEF™ during revision hip arthroplasty (THA).

Methods and Results: This is a retrospective analysis of prospectively collected data on 16 patients (14 females) who underwent revision THA using the REEF™, between 1998 to 2007with a mean follow-up of 16 months (range, 3 to 60).

Indications were peri-prosthetic fractures in 9 cases (Vancouver B1 in one case, B2 in 4 cases and B3 in 4), aseptic loosening with significant bone loss in 3 (Paprosky IIIA in one case, Paprosky IIB in one and Type IV in one), osteolysis (Paprosky IV) secondary to infection in 1, non-union of peri-prosthetic fracture in 2 (Vancouver B2 and B3) and fracture around a spacer in one case.

The mean HHS at 3 months post-operatively was 72 (range, 57 to 76). The median pre-operative/pre-injury University of California, Los Angeles hip rating system (UCLA) was 1. The median UCLA at longest follow-up was 3.5 (range, 1 to 4) with 10 patients having a score greater than 3. Mean time to clinical evidence of implant integration was 4 months (range, 2 to 12). No evidence of subsidence was noted. Four dislocations were seen. No dislocation was seen in the 6 patients who had a Posterior Lip Augmentation Device (PLAD™) inserted at the time of revision THA. One stem fracture occurred requiring revision surgery with a longer REEF™ implant. Two patients died in the immediate post-operative period.

Conclusion: Results of revision THA using the REEF™ implant are encouraging. We recommend the use of the REEF™ with the judicious use of PLAD™ in difficult revision THA.


J Dahl J Rydinge SM Rohrl F Snorrason L Nordsletten

Introduction: C-stem is a triple taper polished femoral stem. The rationale for this design is to achieve an evenly distributed proximal loading of the cement mantle. This design is thought to enhance stability of the stem inside the mantle and lead to bone remodelling medially. There is to our knowledge no randomized trial comparing this stem to a well documented stem. We chose to compare it to the best documented stem in the Norwegian arthroplasty register, the Charnley monoblock.

Methods: 70 patients scheduled for total hip replacement were randomized to either C-stem or Charnley monoblock. All received a 22 mm stainless steel head, OGGEE cup and Palacos Cement with Gentamycin. We used a transgluteal approach in all cases. Harris and Oxford hip scores were measured preoperatively and after two years. Standard X-rays were taken postoperatively and after two years. Radiostereometry (RSA) was done postoperatively and after 3,6,12 and 24 months.

Results: There was no significant difference in Harris or Oxford hip scores after two years.

RSA after two years: (table deleted)

Discussion: Polished tapered stems are designed to sink inside the mantle. Our results confirm this theory for the C-stem. The subsidence is comparable to other collarless tapered stems with good long-term survival. For all other migrations/rotations the C-stem is as stable as the Charnley monoblock. This predicts good long-term results for this stem.


G Cheung JE Oakley AJF Bing MR Carmont N Graham RJ Alcock

Introduction: Primary total hip replacement remains one of the commonest orthopaedic procedures performed. It is yet to be clearly demonstrated whether use of a postoperative drain is of benefit in these procedures.

Methods: We carried out a prospective randomised study comparing the use of autologous reinfusion drains, closed suction drains or no drain to determine their influence on allogenic blood transfusion requirements, length of hospital stay and infection rates. Stratification was carried out for confounding factors.

Results: 153 patients were recruited into the study and randomised to one of the three closely matched groups. There was no significant difference between the mean intra-operative blood loss or post-operative haemaglo-bin levels between the 3 groups. 42% of the suction drain group required post-operative transfusion as compared to 17% of the reinfusion drain group and 12% of the group with no drains. This difference was highly significant (P=0.02) Mean time for the wound to become dry was 3 days, 3.9 days and 4 days in the no drain, re-transfusion drain and suction drain groups respectively. This difference was statistically significant (P=0.03). There was no statistically significant difference in the mean length of inpatient stay.

Discussion: This study demonstrates a significantly higher transfusion rate with closed suction drains compared to reinfusion drains or no drains. With the drive to reduce hospital stay our study supports the considered use of no drain or a reinfusion drain.


A S Rajeev D K Mishra RG Kakwani Shankar N Kashyap

One of the many challenges in revision hip arthroplasty is massive bone loss. Subsidence of the collarless stem with impaction allografting has been reported by several authors. Impaction grafting has emerged as a useful technique in the armamentarium of the revision total hip arthroplasty surgeon. The original technique proposed by Ling has been associated with complications, including femoral shaft fractures, recurrent dislocations, and uncontrolled component subsidence. Modifications in that technique seem to be associated with a reduction in complications.

The aim of this study was to assess the functional outcome of radial impaction grafting in femoral bone defects and the use of collared long stem prosthesis.

A total of 107 patients underwent radial impaction allografting and collared long stem prosthesis during revision THA between 1997 and 2005. The patients with Paprosky type II, IIIA and IIIB defects were included in this study. Average duration between the primary and revision surgery was 9.4 years (Range 6–23 years). Assessment was done using Oxford Hip Score, Harris Hip Score and with plain X-rays. Three patients were lost to follow-up and three patients died due to unrelated causes.

The follow-up period lasted between 12 to 114 months (average – 68.8 months). Three patients who sustained post-operative peri-prosthetic fracture had standard stem inserted in them. None of the patients with long stem sustained peri-prosthetic fracture. Four patients had infection and underwent revision procedure. In this study, using revision for any cause as the end-point, survival of the femoral stem was 93.8%. Subsidence was not recorded in any of the patients in this study. Oxford Hip Score improved from mean pre-operative value of 41.2 to 19.2 post-operatively. Mean Harris Hip Score improved from 40.8 pre-operatively to 83.4 post-operatively.

Subsidence of the prosthesis is commonly encountered with collarless stems and this was not a problem in this study. The risk of peri-prosthetic fracture can be reduced by using long stem prosthesis which bypasses the existing cement mantle by at least two femoral diameters. The radial impaction grafting technique permits the use of revision femoral components with variable stem lengths, neck lengths, and neck offsets.

We conclude that radial imaction graftind along with collared long stem prosthesis is a good solution for massive femoral bone defects while performing total hip arthroplasty.


RW Westerman R Slack

Introduction: In a climate of tightening budgets and rising cost the pressure on those performing complex and expensive surgery is ever increasing.

Patients requiring revision hip surgery are a particular burden on such limited resources.

Hospital trusts are dependent upon adequate remuneration for such complex procedures, a process reliant on accurate coding.

Methods: We performed a retrospective audit of our coding for revision hip surgery. This highlighted significant shortfalls in the coding process. We implemented necessary changes prior to a further prospective audit.

Results: The primary procedure was correctly coded in all our cases throughout, creating a standard tariff (mean £6,897).

However certain procedures enable an additional tariff uplift of up to 70%. Yet these additional procedures (performed in 81% of our procedures) had not been coded; loosing these additional tariff uplifts of 70%.

We involved and educated our coding staff, creating a ‘tick box’ sticker to be placed on every revision hip operation-record and completed by the operating surgeon.

Our subsequent tariff uplifts for these procedures have been significant.

Discussion: Joint replacement surgery is being performed in an ever younger and more active population. Patients are increasingly likely to outlive their prosthesis and peri-prosthetic fracture rates are set to continue rising.

In the modern NHS, surgeons must have a good understanding of complex tariffs. Coding staff are a notoriously poorly paid and undervalued component of any Hospital Trust, and invariably lack the surgical experience to interpret complex procedures.

Trusts must take measures to ensure such large tariff uplifts are not missed for complex procedures.

We explain the tariff process and discuss how improvements can easily be achieved by individual trusts.


J Singh A Malhotra P Mitchell P. G Denn

Introduction: Numerous studies have been carried out to assess the efficacy of tranexamic acid on intra and post operative blood loss and its implications. Many of these studies conclude that there is a need to study the effects of tranexamic acid on actual post Operative blood transfusion, thromboembolic events and hospital stay.

We analyzed the effects of Tranexamic acid on Intra- operative blood loss, post Operative haemoglobin and haematocrit drop, blood transfusion requirement, incidence of deep vein thrombosis and hospital stay in Patients undergoing Total hip arthroplasty.

Methods: Prospective case control study involving 50 patients (25 in each category, ASA class I to III) operated by a single consultant. Patient were given single dose of Intra venous Tranexamic Acid (10 mg/kg,10 minutes pre-incision) and Intra operative blood loss was compared to control group analyzing dry and wet swab weights and irrigation fluid. The actual haemoglobin drop, blood transfusion requirement, average length of stay in hospital and incidence of DVT were noted.

Results: There was 30% reduction in intra operative blood loss in the study group. None of the other parameters show evidence of a statistically significant difference between the groups. The average hospital stay was 7 days in both the groups.

Discussion: We found out that Tranexamic acid makes little difference in terms of actual haemoglobin and haematocrit drop, blood transfusion requirement and hospital stay. Our study didn’t show any rise in deep vein thrombosis in treatment group. The only difference it made was reduction of intraoperative blood loss by 30%. To the best of our knowledge, ours is the only study which combines all these parameters.


NW Emms SC Buckley I Stockley AJ Hamer RM Kerry

Introduction: Between 1990 and 2000 we reconstructed 123 hips in 110 patients using impaction bone grafting with frozen, morsellised irradiated femoral heads and cemented sockets. This review presents the medium to long term survivorship of irradiated allograft in acetabular reconstruction in our cohort of patients.

Patients and Methods: Patients were reviewed in out-patients. Radiographs were examined for union, lucency and component migration.

The mean age at revision with allograft was 64.3 years (26 to 97). 86 hips (70%) in 74 patients were reviewed both clinically and radiologically.

At the time of review 28 patients (29 hips) had died and 5 patients (5 hips) were lost to follow up. Of those patients who had died 18 hips had been followed up to a mean of 66 months (12–145). A further 3 hips were unable to attend for clinical review but had accurate implant-allograft survivorship data.

Their data were included in survivorship analysis to the time of last clinical review.

Results: There have been 19 revisions; 9 for infection, 7 for aseptic loosening and 3 for dislocation. In surviving acetabular reconstructions, union of the graft had occurred in 64 out of 67 hips (95.5%). Radiolucent lines at the bone cement interface were seen in 12 hips (17.9%; 9 in a single DeLee zone and 3 in multiple zones) but none were considered loose. Migration of the acetabular component greater than 5mm was seen in 3 hips (4.5%). Survivorship analysis using revision as an end point for all indications at 10 years was 83.3% (95% C.I. 68 to 89%) and 71.3% (95% C.I. 58 to 84%) at 15 years

Conclusion: Acetabular reconstruction using irradiated allograft and a cemented cup is an effective reliable technique with good results in the medium to long term comparable to series using non irradiated freshly frozen bone.


BM Wroblewski PD Siney PA Fleming

Introduction: Leg length discrepancy in general and leg lengthening in particular has emerged as a topic of interest and a common cause for litigation

Theoretical considerations: Painful mobile hip functions in abduction. The load on the hip is reduced by pelvic tilt to the symptomatic side. For this to be possible the proximal lever - the head neck and the acetabulum - must be relatively intact.

Methods: A method to identify patients at risk for limb lengthening after total hip arthroplasty by establishing the aetiology of abduction deformity of the osteoar-thritic hip.

Clinically: by pelvic tilt to the symptomatic side apparent limb lengthening, restriction of adduction.

Radiologically: by a relatively well preserved geometry of the hip and infero-medial femoral “head –drop” osteophyte.

Results: In a group of 5000 patients presenting for primary Charnley low-frictional torque arthroplasty: 182 (3.64%) 80 males, 102 females, mean age 63 (20–80) were identified as being at risk for post-operative limb lengthening.

Aetiology – Primary: Unilateral 130, Bilateral 10.

– Secondary: Post-surgery 23, post-trauma 10, spinal 6, mixed 3.

122 (67%) had apparent limb lengthening – mean 3.2% and in 43 (24%) limb lengths were equal, 91% had a well preserved architecture and the proximal lever system.

Discussion: The tell tale signs in patients at risk for limb lengthening after total hip arthroplasty are: pelvic tilt to the symptomatic side with apparent limb lengthening, restricted adduction, history of backache, well preserved hip structure and normal contralateral hip.

Conclusion: Awareness of the pattern identifying patients at risk, detailed pre-operative assessment, avoidance of capsule excision and tight hip reduction are essential.


CW McBryde K Theivendran RBC Treacy PB Pynsent

Introduction: Hip resurfacing has gained popularity for treating young and active patients with arthritis. Recent literature has reported increase revision rate amongst females as compared to males undergoing resurfacing. The aim of this study is to identify any differences in survival or functional outcome between male and female patients treated with metal-on-metal hip resurfacing.

Methods: All procedures performed between July 1997 to July 2003 were extracted from the database and grouped based on gender. 1266 patients (1441 hips, 582 female and 859 male patients) were identified. The preoperative diagnosis, Oxford hip score, component size, post operative complications and revisions were recorded. Failures included revision of either the femoral or acetabular components.

Results: The mean follow up was 5.5 years. There were 52 revisions in total (30 in female and 22 in male group). The 8 year survival in the male and female groups were 96.1% and 91.5% respectively which is significantly different (p=0.0006). The size of the femoral component was significantly associated with revision (p=0.0008). Cox proportional hazard modelling including gender, aetiology and femoral component size identified a diagnosis of osteoarthritis reduced the risk of revision of 0.2 times (p=0.0004). However, SUFE was significantly associated 5.57 times increased risk of revision (p=0.0019). With every millimetre increase in head size there was a reduction in risk of revision of 0.89 (p=0.0098). By inclusion of all variables in this model gender was found not to be significantly associated with failure.

Conclusion: This study demonstrates that although females may initially appear to have a greater risk of revision this is related to differences in the femoral size and pre-operative diagnosis between the genders. Patient selection for resurfacing is best made on size and diagnosis rather than gender.


H. Wynn Jones T. Harrison R. Clifton B. Akinola K. Tucker

Introduction: Leg length discrepancy (LLD) following total hip replacement (THR) is not uncommon. Some patients are symptomatic, with problems such as gait imbalance or back pain. LLD is a potential cause of litigation following THR.

We have observed that some patients perceive their LLD to be much greater than the true LLD. A large LLD is sometimes reported by therapists, despite only a small true LLD.

We have found that abduction tightness is a potent cause of apparent LLD, and report our investigations into this phenomenon.

Method: We have identified a series of patients with abductor tightness and a significant apparent LLD. The LLD becomes apparent when the operated leg is adducted to the midline (or when the patient stands with their ankles together). This causes the contralateral pelvis to elevate and the un-operated leg to “shorten”.

Clinical photographs and videos have been produced to demonstrate this phenomenon.

A 2-dimensional model has been made to demonstrate how the degree of abduction, offset and over-lengthening affect this phenomenon.

A computer model has been used to quantify these effects.

Results: An abduction contracture after THR will cause the un-operated leg to be apparently and functionally short, even in the absence of a true discrepancy.

Even with only minor abductor tightness, increasing the true length will disproportionately increase the apparent LLD.

In the presence of tight abductors, increasing the offset will cause apparent shortening in the contra-lateral limb.

Patients are who have adequate adduction are frequently unaware of true lengthening.

Conclusion: An abduction contracture is a potent cause of apparent LLD. Even a small degree of true over lengthening will be greatly magnified by this phenomenon. We recommend careful clinical assessment for abductor tightness when examining patients complaining of a LLD after THR.


SS Jameson DJ Langton AVF Nargol

Introduction: Excellent medium term results have been reported with the BHR hip resurfacing implant. A number of modifications have been made to the latest designs in an attempt to preserve acetabular bone stock, improve function and prolong survival. We present the clinical and radiological results from the first independent series of ASR resurfacings.

Methods: The first consecutive series of 214 ASR hip resurfacings (192 patients) were followed up prospectively. No patients were lost to follow-up. The mean age of patients at implantation was 56 years and 40% were female. All patients had pre- and 2-year post-operative Harris Hip Scores (HHS) and UCLA activity scores. Radiographic and implant survival analysis was performed at 24–54 months following implantation.

Results: One hundred and seventy-three hips (87%) had an excellent Harris Hip Score (90 or above). Mean postoperative UCLA activity score was 7 and 92% were highly satisfied with the outcome. There were eleven revisions (5.1%). Four (1.9%) had femoral neck fractures (three had a femoral neck notch), two (0.9%) collapsed secondary to avascular necrosis and five (2.3%) were revised because of ongoing pain, as a result of metal wear debris.

Discussion: Although the fracture rate is similar to reports in the literature, the overall revision rate was higher. Rates of wear debris-related failure is concerning. Further investigation of specific implant failure is necessary.


B. J Ollivere C. Darrah T. Barker J. Nolan M. Porteous

Introduction: As candidates for arthroplasty become younger and life expectancy increases the required working life of a total hip arthroplasty continues to rise. Hip resurfacing offers potential further advantages in young patients as minimal bone resection makes for easier revision, and the design allows for an increased range of movement. The Birmingham Hip Resurfacing (BHR) is the first of the second generation hip resurfacings.

Reports are beginning to emerge of unexplained failure, pseudotumour formation, individual cases of metallosis. Joint registry data also demonstrates an unexplained high early failure rate for all designs of hip resurfacing. This paper examines the rate and mode of early failures of the BHR in a multi-centre, multi-surgeon series.

Methods: All patients undergoing BHRs in our two centres were recruited prospectively into our arthroplasty follow up programme. Patients have been followed up radiographically and with clinical scores.

Results: Mean radiographic and clinical follow up was to 43 months (range 6 – 90 months). Of the 463 BHRs two have died and three are lost to follow up. Thirteen arthroplasties (2.8%) have been revised. Eight for pain, three for fracture, two for dislocation and one for sepsis. Of these nine were found to have macroscopic and histological evidence of metalloisis. Survival analysis at 5 years is 95.8% (CI 94.1 – 96.8%) for revisions and 96.9% (CI 95.5 – 98.3%) for metallosis.

Discussion: Histopathological examination demonstrated a range of inflammatory changes including necrosis, inflammation, ALVAL and metal containing macrophages. Not all features were associated with each patient and it is likely that these features form part of the spectrum of metal wear debris disease.

The likely rate of metallosis is 3.1% at five years. Risk factors for metallosis in this series are female sex, small femoral component, high abduction angle and obesity. We not advocate use of the BHR in patients with these risk factors.


T Madhu M Akula R Raman H Sharma GV Johnson

The aim of the paper is to provide an independent single surgeon experience with BHR after a seven-year follow-up.

A cohort of 117 hips in 101 consecutive patients operated by the senior author between Jan 1998 and Dec 2002 were assessed to note their clinical, radiological and functional outcome after a mean follow-up of 7 years (5–9.4 years). Primary osteoarthritis was seen in 73 hips and secondary in 44 hips. Their mean age at surgery was 54 years (range 20–74years). At latest follow-up their mean flexion was 100°and their mean functional outcome scores were respectively: Oxford hip score of 21.5 (12–52, mode 12); Harris hip score of 84.8 (25–100, mode 97), Charnley modification of Merle d’ Aubigné and Postel scores were 4.8 for pain, 4.3 for walking and 5.4 for movement; and SF-36 (physical component 43.9 and mental component 51.45). Failure in the study was defined as revision for any reason. Revision was undertaken in 8 hips (6.8%), five within the first year for periprosthetic fracture neck of femur and 3 hips after the end of 5-year follow-up (2 for advance collapse of the femoral component in patients’ with avascular necrosis of the femoral head and 1 hip for sepsis).

The Kaplan-Meier survival with revision as end point at minimum 5-years of follow-up was 95.7% (95% CI 92–99%) and overall survival at an average 7-years was 91.7% (95% CI 86–97.6%). All the failures were due to the femoral component. However, the reported survival with the use of traditional uncemented and cemented femoral stems is beyond 99% at similar period of follow-up. Patient selection particularly in patients with secondary osteoarthritis is therefore a critical factor when choosing BHR components.


DJ Langton AP Sprowson S Jameson TJ Joyce M Reed P Partington I Carluke AVF Nargol

Background: There are no large comparative metal ion studies of commercially available hip resurfacing devices which have taken into account the effects of femoral size and cup inclination and anteversion.

Patients and methods: Metal ion analysis is carried out routinely at our independent centre. We present the metal ion results of 95 unilateral ASR patients and 70 unilateral BHR patients. For all patients, acetabular cup orientation was assessed using EBRA software. Patients with other metallic implants and those within 12 months of surgery were excluded.

Results: Whole blood/serum chromium (Cr) and cobalt (Co) concentrations were inversely related to femoral component size in both the ASR and BHR group (p< 0.05). Cr and Co levels were only seen to increase in the BHR group when the cup was implanted with an inclination greater than 55°. A significant relationship was identifed between the anteversion of the BHR cup and Cr and Co (p< 0.05 for Co, Spearman Rank correlation), with an increase in ions observed at anteversion angles > 17°. Cr and Co were more strongly influenced by cup position in the case of the ASR, with an increase in metal ions observed at inclinations greater than 45° and anteversion angles of < 10° and > 20°.

Discussion: The increased tolerance of the BHR cup to inclinations between 45–55° is likely due to the larger BHR cup providing greater protection against edge loading. When the cohort was divided by gender, the median Cr concentrations of the male ASR patients were significantly lower than those of the BHR males (p< 0.001). This suggests that in larger components positioned at more satisfactory angles of inclination and anteversion, the lower clearance of the ASR proves more significant than the extra coverage provided by the BHR cup. The BHR appears to be more sensitive to changes in anteversion than inclination.


YM Kwon S Ostlere P Mclardy-Smith R Gundle D Whitwell CLM Gibbons A Taylor H Pandit S Glyn-Jones N Athanasou D Beard HS Gill DW Murray

Introduction: Despite the satisfactory short-term implant survivorship of MoM hip resurfacing arthroplasty, symptomatic abnormal periprosthetic soft-tissue masses relating to the hip joint, ‘pseudotumours’, are being increasingly reported. These were found be locally destructive, requiring revision surgery in 75% of patients. Asymptomatic pseudotumours have not been previously investigated.

Methods: The aims were: (1) to investigate the prevalence of asymptomatic pseudotumours; and (2) to investigate their potential association with the level of metal ions. A total of 160 hips in 123 patients with a mean age 56 years (range 33–73) were evaluated at a mean follow-up of 61 months (range 13–88). Radiographs and OHS were assessed. Patients with a cystic or solid mass detected on the ultrasound/MRI had an aspiration or biopsy performed. Cobalt and chromium levels were analysed using Inductively-Coupled Plasma Spectrometer.

Results: Pseudotumours were found in 6 patients (5F: 1M). In 80% of bilateral cases, it was found in both sides. Histological examination showed extensive necrosis and diffuse lymphocyte infiltration. The presence of pseudotumour was associated with higher serum cobalt (9.2 μg/L vs. 1.9μg/L, p< 0.001) and chromium levels (12.0μg/L vs. 2.1μg/L, p< 0.001); higher hip aspirate cobalt (1182 μg/L vs. 86.2μg/L, p=0.003) and chromium levels (883μg/L vs. 114.8μg/L, p=0.006); and with inferior OHS (23 vs. 14 p=0.08).

Discussion: The prevalence of asymptomatic pseudotumour (5%) was higher than previously reported for the symptomatic pseudotumours (1%). There was a sixfold elevation of serum and a twelve-fold elevation of hip aspirate levels of cobalt and chromium in patients with pseudotumours. This suggests that pseudotumours may be a biological consequence of the large amount of metal debris generated in vivo. The association between pseudotumour and elevated metal ion levels might theoretically be explained by either systemic hypersensitivity responses to metal ions or local cytotoxic effects due to a high level of metal ions.


R Gilbert G Cheung A Carrothers J Richardson

Introduction: Conversion of failed femoral components of total hip resurfacing to conventional hip replacement is reportedly a straightforward procedure. There is little published to qualify this and what is available suffers from small study numbers and various combinations pre and post-operative implants.

Method: Between 1997 and 2002, the Oswestry Outcome Centre prospectively collected data on 5000 Birmingham Hip Resurfacings (BHRs) performed by 141 surgeons, at 87 hospitals. To date 4526 have survived, 135 died and 165 are lost to follow-up.

174 have been revised, of which 60 were failures of the femoral component.

We reviewed modes of failure and post-revision clinical outcomes in this sub-group.

Results: Isolated femoral component failure accounted for 60 hips (1.2%). 28 femoral neck fractures, 14 femoral head collapses, 13 femoral component loosenings, 3 avascular necroses (AVN), 1 femoral loosening followed by fracture and 1 dislocation. Mean time to revision surgery was 2.6years (1.8years for neck fracture; 3.4years femoral loosening, head collapse and AVN).

All acetabular components were left in situ. At revision surgery 25 cemented, 25 uncemented and 10 unknown femoral prostheses were used with 56 BHR modular heads, 2 custom-made Exeter heads and 2 Thrust Plate heads.

47 patients completed outcome scores post-revision surgery. Median modified Harris Hip Score was 82 (IQ range=63–93) and Merle d’Aubigne score was 14 (IQ= 9.5–15) at a mean follow up of 3.9years post-revision.

The 4526 surviving resurfacings had a median hip score of 96 (IQ=87–100) p≥4.558x10-8 and median Merle score of 17 (IQ=14–18) p≥1.827x10-7. Mean 7.0 years follow up.

There was no difference in outcomes between cemented and uncemented revision components nor were there differences between fractured neck of femur and femoral loosening, head collapse or AVN.

Discussion: Following revision of the femoral component to a conventional hip replacement, function is significantly worse than surviving resurfacings.


DJ Langton SS Jameson TJ Joyce S Natu R Logishetty C Tulloch AVFN Nargol

In our independent centre, in the period from January 2003 to august 2008, over 1100 36mm MoM THRs have been implanted as well as 155 Birmingham Hip Resurfacing procedures, 402 ASR resurfacings and 75 THRs using ASR XL heads on SROM stems.

During this period we have experienced a number of failures with patients complaining of worsening groin pain at varying lengths of time post operatively. Aspiration of the hip joints yielded a large sterile effusion on each occasion. At revision, there were copious amounts of green grey fluid with varying degrees of necrosis. There were 11 failures of this nature in patients with ASR implants (10 females) and 2 in the 36 MoM THR group (one male one female).

Tissue specimens from revision surgery showed varying degrees of ‘ALVAL’ as well as consistently high numbers of histiocytes. Metal debris was also a common finding.

A fuller examination of our ASR cohort as a whole has shown that smaller components placed with inclinations > 45° and anteversions < 10 or > 20° are associated with increased metal ion levels. The 11 ASR failed joints were all sub optimally positioned (by the above definition), small components.

Explant analysis using a coordinate measuring machine and out of roundness device confirmed greater than expected wear of each component. The lower number of failures in the 36mm MoM group, as well as the equal sex incidence, suggests that the majority of these failures are due to the instigation of an immune reaction by large amounts of wear debris rather than adverse reactions to well functioning joints. It is likely that small malpositioned ASRs function in mixed to boundary lubrication, and this, combined with the larger radius of these joints compared to the 36mm MoM joints, results in more rapid wear.


G Grammatopoulos H Pandit Y Kwon PJ Singh R Gundle P. McLardy-Smith DJ Beard HS Gill DW Murray

Introduction: Metal on metal Hip Resurfacing Arthroplasty (MoMHRA) has gained popularity due to its perceived advantages of bone conservation and relative ease of revision to a conventional THR if it fails. This retrospective study is aimed at assessing the functional outcome of failed MoMHRA revised to THR and comparing it with a matched cohort of primary THRs.

Method: Since 1999 we have revised 53 MoMHRA to THR. The reasons for revision were femoral neck fracture (Group A, n=21), pseudotumour (Group B, n=16) and other causes (Group C, n=16: loosening, avascular necrosis and infection). Average follow-up was 3 years months (1.2–7.3). These revisions were compared with 106 primary THRs which were age, gender and follow-up matched with the revision group in a ratio of 2:1.

Results: The mean Oxford Hip Score (OHS) was 20.1 (12–51) for group A, 39.1 (14– 56) for group B, 22.8 (12–39) for group C and 17.8 (12–45) for primary THR group. In group A, there were three infections requiring further revisions. In group B, there were three recurrent dislocations, three patients with femoral nerve palsy and one femoral artery stenosis. In group C, there were no complications. The differences in clinical and functional outcome between group B and the remaining groups as well as the difference in the outcome between group B and control group were statistically significant (p < 0.05).

Conclusions: THR for failed MoMHRA was associated with significantly more complications, operation time and need for blood transfusion for the pseudotumour group. In addition, the revisions secondary to pseudotumour also had significantly worse functional outcome when compared to other MoMHRA revisions or primary THR.


J Daniel H Ziaee C Pradhan DJW McMinn

Introduction: Modern metal-metal (MM) Hip Resurfacing (HR) was developed as a conservative option for young patients with severe arthritis. Whilst some centres have reported excellent early results, other series have found a high incidence of osteolysis and still others reported soft tissue necrosis and periarticular changes. These are not always detectable with conventional imaging. This is the first 10 year clinico-radiological and multi-slice CT assessment of hip resurfacings.

Methods: The study includes 124 consecutive single-surgeon HRs (113 patients), mean age 52.8 years (27 to 75), mean follow-up 10.6 (10.4 to 10.8 years). Diagnoses include primary osteoarthritis (102), osteonecrosis (6), dysplasia (12) and others (4). Five patients (7 hips) died 5 to 10.3 years later from unrelated causes. Unrevised patients are reviewed with questionnaires, conventional radiographs and CT assessment.

Results: With revision for any reason as the end-point there were seven failures 0.4 to 9.7 years after operation (one failed from femoral neck fracture, four due to femoral head collapse and two were deep infections, 94% 10-year cumulative survival. Five cases showed osteolysis and four had neck thinning. No aseptic loosening, migration or malorientation is found. No patient is awaiting a revision.

Discussion and Conclusion: The performance of MMHR continues to be good at 10 years. Arthroplasty devices are known to manifest two phases of failure, one during early years and another in later years. Early failure with this device has been low. The interim years continue to be promising and we are yet to find out when the late failures are likely to occur.


J Daniel H Ziaee C Pradhan DJW McMinn

Introduction: End-stage hip arthritis secondary to femoral head avascular necrosis (AVN) in young patients is a therapeutic challenge. Hip resurfacing (HR) has been showing excellent medium-term results in patients with osteoarthritis. Destructive changes in a large segment of the femoral head from AVN can increase the risk of postoperative femoral neck fracture or femoral head collapse following a resurfacing procedure. Careful patient selection and precise operative technique are vital to success. This is a study of the results of HR in patients with arthritis secondary to femoral head osteonecrosis.

Methods: This is a single-surgeon consecutive series with a 4 to 14-year (mean 8.6) follow-up. 95 patients (104 hips) with Ficat-Arlet grade III or IV osteonecrosis and treated with HR at a mean age of 43 (range 18 to 68) years. Two patients died due to unrelated causes and none is lost to follow-up. Revision for any reason was the end-point. Unrevised patients were assessed clinically and with Oxford hip scores and AP and lateral radiographs.

Results: Nine failures (1 fracture, 5 femoral head collapse, 2 infections, 1 cup loosening) give a failure rate of 8.7% and a cumulative survivorship of 89% at 14 years. In one further patient the femoral component has tilted into varus. He is asymptomatic but knows that he may need a revision if symptoms develop. No other patient shows clinical or radiological adverse signs.

Discussion and Conclusion: Several studies suggest that the results of arthroplasty are generally worse in AVN compared to those in osteoarthritis. HR has demosntrated good results in young patients with good quality femoral head bone. Reviewing the above results it appears to us that the relatively poorer cumulative survival observed in patients with a diagnosis of AVN (89%) makes AVN a relative contraindication to hip resurfacing.


M Hossain A Ali J Andrew

Introduction: We prospectively followed all hip fracture patients admitted between 2004–2006, identified cases where the intention was to treat conservatively and compared their functional outcome and mortality with a similar cohort treated surgically over the same period.

Methods: We recorded length of hospital stay, place of discharge, pre and post-fracture mobility and residence, 30 day and 1 yr mortality, re-admission and delayed surgery. The group treated surgically was recruited and matched for age, gender, pre and post fracture mobility, mental confusion and independence with the conservatively treated group.

Results: 25 patients were treated conservatively. 22 patients treated surgically over the same period were recruited. The mean hospital stay was 13 days in both groups. There were 4 extracapsular (3 displaced) and 21 intracapsular fractures (5 displaced) in the conservative arm and 11 extracapsular and 9 intracapsular fractures in the surgically treated arm. 4 patients from the conservative treatment group underwent late surgery 20 days – 2 months after the index event. Surgically treated group had 11 dynamic screw fixation, 1 cannulated screw, 1 total hip replacement and 7 hemiarthroplasty. 9/14 of the conservatively treated patients were mobile independently or with aid after treatment compared to 11/16 patients after surgery. 7/16 patients treated conservatively were living independently in their own residence, compared to 10/14 patients in the operatively treated patients. 1 month and 1 year mortality in conservatively treated group was 4/21 and 7/21 respectively compared to 1/20 and 5/20 in the operative fixation group. There was no statistically significant difference in mobility, residence or mortality between the two groups (Fisher exact test, p > 0.05).

Discussion: Conservative management after hip fracture in medically unfit patients does not result in statistically significant difference in functional outcome or mortality compared to patients treated surgically.


M Hossain DJ Parfitt DJ Beard D Murray J Nolan JG Andrew

Introduction: We investigated the relationship between psychological distress and outcome after total hip replacement (THR) in the Exeter Primary Outcome Study (EPOS).

Materials & Methods: Data were collected from a number of centres across England between January 1999 and January 2002 for patients undergoing primary hip replacement using the cemented Exeter femoral component (Stryker). We recorded the Oxford Hip Score (OHS) for physical function and SF36 questionnaire for both physical and mental domain assessment annually for five years. We dichotomised the patients into the mentally distressed (MHS < 50) and the not mentally distressed (MHS ≥ 50) groups based on their pre-operative Mental Health Score (MHS) from the SF36 score.

Results: Complete data were available for 455 (407 not distressed and 48 distressed) patients. Pre-operative OHS and SF-36 score was significantly worse in the distressed group (both p< 0.001). Mean OHS improved from 43 to 20 at 1 year after surgery and remained the same thereafter in the non distressed group. In the mentally distressed group pre-operative mean OHS of 48 improved to 22 at 1 year after surgery. Maximum improvement in OHS occurred in the 1st yr after surgery. Mean MHS improved from 76 to 81 at 1 year after surgery and remained the same thereafter in the non distressed group. Mean MHS improved from 35 to 62 at 1 year after surgery, reaching 65 at 5 years after surgery in the mentally distressed group. The maximum improvement in MHS occurred in the 1st yr after surgery.

Conclusion: Pre-operative psychological distress did not compromise functional outcome after hip arthroplasty. There was a substantial improvement in mental distress in patients with mental distress prior to surgery. Both groups of patients experienced improvement in Oxford Hip Score, which was maximal by 1 year after surgery and was maintained over the 5 year follow up.


N.A. Sandiford S.K. Muirhead-Allwood J. Skinner C. Kabir J. Hua

Background: There is no consensus on the most appropriate prosthesis for treating osteoarthritis (OA) of the hip in young, highly active patients. Modern hip resurfacing is bone conserving, more stable and theoretically easier to revise than total hip arthroplasty. Early results of metal on metal resurfacing have been promising. We have compared two well matched cohorts of patients with regard to function, pain relief and patient satisfaction.

Methods: This prospective study included 2 cohorts of well matched patients treated with hip resurfacing (137 patients, 141 hips) and custom uncemented (CADCAM) stems (134 patients, 141 hips). All procedures were performed by a single surgeon. Outcome measures included Oxford, WOMAC and Harris hip scores. Statistical analysis was performed using the unpaired student’s t- test.

Results: One hundred and thirty four and 137 patients were included in the hip replacement and resurfacing groups respectively. The mean age of these patients was 54.6 years. The mean duration of follow up for the resurfacing group was 19.2 months compared to 13.4 months for the replacement group.

Pre operative oxford, Harris and WOMAC scores in the THA group were 41.1, 46.4 and 50.9 respectively while the post operative scores were 14.8, 95.8 and 5.0. In the HR group, pre- operative scores were 37.0, 54.1 and 45.9 respectively compared to 15.0, 96.8 and 6.1 post operatively. The degree of improvement was similar in both groups.

Conclusion: There was no significant difference in short term outcome between the groups of patients treated with hip resurfacing and total hip arthroplasty in the short term.


H Ziaee C Pradhan J Daniel DJW McMinn

Introduction: Metal-metal (MM) hip resurfacing is being increasingly used in the young. The main concern is the invariable systemic metal ion release. In young women the concern is that metal ions cross the placenta in pregnant women with MM bearing arthroplasties. We earlier presented an interim report on this subject the results of which ate established in a larger cohort

Methods: This is a controlled cross-sectional study of women of child-bearing age with MM resurfacings. (n= 22, mean age: 32 years, mean duration after resurfacing 60.3 months, 3 bilateral). The control group consisted of 24 pregnant subjects who did not have a metallic implant (mean age 31.3 years). Whole blood specimens were obtained from the mothers and umbilical cords at delivery.

Results: None of the babies had a congenital anomaly. Cobalt and chromium were detectable in all specimens including all controls. In the study group, mean cord metal ion levels were significantly lower than the maternal cobalt (p < 0.05) and chromium (p < 0.0001). In the control group, the mean cord blood metal levels differed very little from the maternal levels (p > 0.5). The mean difference in cord chromium between the study (0.33 μg/l) and control groups (0.21 μg/l) was not statistically significant, although the difference in cord cobalt was significant (0.41 μg/l).

Discussion: The differences between maternal and cord metal ions in the control patients is very small indicating that, under these circumstances the placenta allows an almost free passage of metal ions. The relative levels in the study group reveal that the placenta exerts a modulatory effect on metal transfer when maternal levels are above normal. Cobalt and chromium cross the placenta, irrespective of the presence of metal devices and therefore there is a need to continue efforts to reduce metal ion release.


Theruvil N Vasukutty D Higgs N Hancock DG Dunlop JM Latham

Introduction: The advantages of metal on metal bearings (MoM) include improved wear characteristics and lower dislocation rate. Metal sensitivity and Aseptic Lymphocyte Dominated Vasculitis Associated Lesion (ALVAL) reaction are becoming increasingly recognised. The BOA has recently issued a statement regarding MoM bearings. They suggested that any revisions for symptoms of pain and soft tissue reaction should be reported to the MHRA and histological specimens forwarded to the Stanmore Retrieval Centre.

Methods and results: We report four patients (all females), who presented with late dislocation of a large diameter MoM bearing (three following total hip replacements and one following resurfacing). They all made good initial recovery with complete relief of pain. They developed pain around groin between one and two years following the surgery. Inflammatory markers were normal. MRI/Ultrasound scanning showed the presence of cystic lesions around the hip. They all presented with relatively late dislocation (26 months to six years). At exploration there was a large joint effusion with necrosis and detachment of the abductors. A characteristic finding was an avascular bare trochanter stripped free of any soft tissues. Histology showed a predominantly histiocytic response in keeping with the findings of Willert and Pandit.

Discussion: In the absence of any obvious causes for dislocation, one should have a high index of suspicion for the possibility of metal hypersensitivity causing joint effusion, muscle necrosis and thereby leading to instability due to the progressive periosteal and soft tissue erosion. These patients should be considered for early revision of the bearing surface to prevent further damage to the muscle and bone. If the abductors are completely detached a more constrained type of bearing should be used to improve the stability. To the best of our knowledge this is the first report of this unusual complication following MoM bearings.


BGI Spiegelberg SA Hanna S Tai K Gokaraju R Pollock RWJ Carrington SR Cannon TWR Briggs

Introduction: Metal-on-metal arthroplasties are being used for their increased durability and reduced requirement for revision. Previous data reports that metal-on-metal bearing surfaces release three times more cobolt and chromium ions than metal-on-polyethelene hip replacements. Data also suggests that these metal ions can cause DNA damage.

Method: A prospective study of patients (aged 60–80), meeting exclusion criteria were selected and randomised to metal-on-metal or metal-on-polyethylene articulation. Patients were reviewed preoperatively (control model) and at 3 months, 6 months and one year postoperatively. On each occasion blood tests were taken to quantify metal ion levels (chromium, cobalt, nickel, vanadium and titanium) and chromosome aberrations in T lymphocytes using 24 colour fluorescent in situ hybridization (FISH).

Results: The number of chromosome aberrations increased with time; in particular there was a statistically significant increase in aneuploidy after one year, there was also an increase in chromosome translocations. There was a similar increase in blood concentration of metal ions over this same time period which proved significant. Higher levels of metal ions were seen in the metal-on-metal group when compared with the metal-on-polyethylene.

Conclusion: This study has highlighted the effects of metal ions on chromosome replication in particular causing aneuploidy aberrations. This provides evidence of the short-term effects of metal-on-metal arthroplasty but further research needs to be undertaken to assess long-term risk and also the risk associated to other cell lines.


J Dahl B. Nivbrant P Søderlund L Nordsletten Stephan M. Röhrl

Introduction: Increased wear is associated with aseptic loosening and late dislocations. Hard on hard bearings may reduce wear but still have topics of concern such as free metal ions in metal on metal bearings and the risk for fracture in ceramic articulations. Ceramic heads against conventional polyethylene is also used with the intention to reduce wear. But this effect has not been conclusively documented in the literature and is still discussed. 87 patients were operated consecutively by the same surgeon with the same surgical technique. All patients received a cemented all poly cup sterilized with irradiation in inert atmosphere and a cemented stem. Head size was 28 mm in all patients. 40 patients received cobalt-chrome heads and 47 patients aluminiumoxid heads. The patients were followed with RSA for 10 years and analysed for wear.

Results: Mean (SEM) wear for the group with cobalt chrome heads was 0.93 mm (0.13) and for the group with aluminiumoxide was 0.43 mm (0.08) (p = 0.001).

Discussion: We found significantly less wear with aluminumoxide heads compared to cobalt-chrome heads. The wear results in the cobalt-chrome group correlate well to wear values in the literature for conventional polyethylene. Although the polyethylene in this study is partly cross-linked (3Mrad) it is not clear whether these results can be extrapolated directly to the use of highly cross-linked PE. If longer follow-ups confirm the mechanical stability of highly cross-linked PE, ceramic heads might contribute additionally to the reduction of wear.

In conclusion we found significantly reduced wear for aluminumoxide heads compared to cobalt chrome heads which could be beneficial for young and active patients.


AJ Hart JN Lenihan JP Cobb J Henckel

Introduction: The successful outcome from metal-on-metal hip resurfacing is partly dependent on the restoration of the natural biomechanics of the hip joint. Valid measurement of the geometry of the reconstructed hip is challenging using plain radiographs. CT is more accurate and precise yet rarely used to assess hip geometry. Our aims were 1) to quantify the agreement between radiographic and CT measurement of horizontal femoral offset (HFO); 2) to determine the relationship between HFO and patient gender and size; and 3) To compare HFO of the reconstructed hip to the contralateral hip.

Method: We used plain radiograph and CT data from 42 patients (23 male and 19 female) from a consecutive series with unilateral metal-on-metal hip resurfacings. We measured HFO of both hips (component and contralateral) using plain radiographs (with PACS) and CT (with Robin 3D software). Pelvic width and radial head sizes were measured on CT. Measurements were made in triplicate by 2 observers.

We graded the contralateral hip for severity of joint space narrowing on plain radiographs.

Results: There was considerable disagreement between CT and plain radiographs for HFO. HFO was statistically different between genders (p=0.0004). HFO correlated with femoral head radius (0.57, p=0.0002), but not patient size (for height (0.29, p=0.13), or pelvic width (0.25, p=0.11). There was a wide range of HFO of the contralateral hips that was comparable to the reconstructed hip.

Conclusion: To our knowledge this is the first study to show the importance of measuring HFO using CT. HFO was found to be correlated to gender and femoral head radius, but not with any other parameters of patient size. The wide range of offset was considerably greater than is available from current total hip replacement designs. Hip resurfacing may overcome this.


SJ Bennet OMB Berry J Goddard JF Keating

Introduction: We investigated the incidence, risk factors and outcome of acute renal dysfunction (ARD) in patients with a fractured neck of femur.

Methods: 170 consecutive patients were prospectively included in the Scottish hip fracture audit database and retrospectively analysed. Historically, lack of consensus definition hindered accurate reporting of ARD. We defined ARD using the ‘RIFLE’ criteria recently described by the Acute Dialysis Quality Initiative (ADQI) Group.

Results: 27 patients (16%) developed ARD. Risk factors were male sex, vascular disease, hypertension, diabetes, chronic kidney disease and pre-morbid use of nephro-toxic medications (p< 0.01). Inpatient, 30 and 120 day mortality was higher in the ARD group 19%, 22% and 41% respectively, versus 0%, 4% and 13% in the non-ARD group (p< 0.01) Length of hospital stay was significantly longer in the ARD group; 20 days compared to 13 days for patients in the non-ARD group (p< 0.01). Pre and post-operative complications were 12 and 5 times more frequent respectively in the ARD group (p< 0.01).

Discussion: Acute renal dysfunction is an important adverse event in this population. Awareness of risk factors and serial measurements of renal function will enable early identification and focused monitoring of these patients.


S Rajkumar GC Singer

Introduction: Peri-prosthetic fractures following hip resurfacing arthroplasty are difficult fractures to treat. The surgeon is faced with the task of either attempting to fix the fracture if feasible or revise the resurfacing implant to a conventional total hip replacement.

Method & Results: Here we report of a novel way of fixing a peri-prosthetic fracture following resurfacing hip arthroplasty using Polyaxial locking plate fixation. A 53 year old man sustained a intertrochanteric fracture below his resurfacing metal on metal hip prosthesis following a fall. He had his hip resurfaced 3 years back for osteoarthritis in another hospital. He underwent surgery to fix the fracture using a polyaxial locking plate with no post-operative complications. He was mobilised non-weight bearing for the initial six weeks and weight bearing as tolerated thereafter. He went on to union and was moblising without any problems in three months time. His follow-up x-rays at 8 months showed fracture healed with no evidence of prosthesis problems.

Discussion: There are various methods of treating a periprosthetic fracture of a well fixed resurfaced hip implant. The two types of management are open reduction and internal fixation and revision to a stemmed hip implant. These fractures can be fixed with cannulated hip screws, blade plate device or plating with screws avoiding the stem of the resurfacing prosthesis. We used the polyaxial locking plate device with good result thereby avoiding the need for revision surgery with its attendant risks. Using this implant is a useful alternative for these fracture patterns.


S Rajkumar J Humphries J Howarth R Kucheria

Introduction: We undertook an audit study to find out patient perception of being seen by a nurse practitioner in the clinic for a follow up appointment instead of a consultant and satisfaction with the joint clinic.

Methods and materials: 100 patients were surveyed following their post-operation review with the nurse. Data was collected prospectively over a period of 6 months. Patients were asked to complete the questionnaire on the day of their appointment and to hand the survey prior to leaving. Hence we had 100% response rate.

Results: Majority of the respondents were female (61%) with 50 % having had total hip replacements and the rest had knee replacements. 99% of respondents (94/95) felt that enough time was spent with them during the appointment. All respondents (100%) reported that they were able to ask questions and were answered satisfactorily. The consultant saw 26% of respondents; further 6% was seen by a registrar and the rest 68% were seen by the nurse specialist. Reasons for being seen by a doctor included check up or assessment, reviewing stitches and infection. 42% of respondents (33/79) were referred for further treatment either by the consultant (33%), nurse (64%) or registrar (3%). Reasons for further treatment included physiotherapy, plaster room, and further follow up (check up) appointment at 3–6 months to review the patient following surgery. 100% of respondents (97/97) were satisfied with the combined consultant/nurse clinic. 3 did not record their response. The vast majority of respondents (80%, 79/99) reported that they ‘don’t mind’ who they would have been seen by in the clinic.

Discussion: The results indicate that patients are satisfied with the current clinic arrangements i.e. nurse-led clinic with the consultant being available. Hence there is a definite role for nurse led clinics for joint replacement surgery follow-ups.


S W Veitch J R Howell M J Hubble G A Gie JA Timperley

The review of the first 325 Exeter Universal hips reported good long term survivorship despite the majority of cups being metal backed. We have reviewed the long term performance of the concentric all-polyethylene Exeter cups used with the Universal Exeter stem.

Clinical and radiographic outcomes of 263 consecutive primary hip arthroplasties in 242 patients with mean age 66 years (range, 18 to 89) were reviewed. 118 cases subsequently died none of whom underwent a revision. Eighteen hips have been revised; thirteen for aseptic cup loosening, three for recurrent dislocation and two for deep infection. Three patients (four hips) were lost to follow-up. The minimum follow-up of the remaining 123 hips was 10 years (mean 13.3 years, range 10–17). Radiographs demonstrated 6 (6%) of the remaining acetabular prostheses were loose. The Kaplan Meier survivorship at 14.5 years with endpoint revision for all causes is 91.5% (95% CI 86.6 to 96.2%). With endpoint revision for aseptic cup loosening, survivorship is 93.3% (CI 88.8 to 97.8%).

This series included a number of complex cases requiring bone blocks and/or chip autograft for acetabular deficiencies. The concentric all polythene Exeter cup and Exeter stem has excellent long term results particularly when factoring in the complexity of cases in this series.


N Vannet N Ferran A Thomas A Ghandour D O’Doherty

Introduction: Trochanteric bursitis is a common hip problem that can be refractory to treatment. The available modalities of treatment can be less effective. We evaluated the use of extra-corporeal shockwave therapy treatment for trochanteric bursitis.

Methodology: 22 patients with the clinical and radiological (in 6 patients) diagnosis of trochanteric bursitis were treated in a dedicated shockwave therapy clinic using Swiss dolocast radial shockwave therapy machine. 3 sessions of treatment were given one week apart, delivering 2000 impulses at 10 Hz at each session. Patients were evaluated prior to treatment, 3 months, 6 months and 12 months following their treatment. The visual analogue score (VAS) was used in all patients pre and post treatment. Hip disability and osteoarthritis score (HOOS) was performed post-treatment.

Results: Between December 2005 and November 2008 22 patients were treated for symptoms of trochanteric bursitis. There were 17 women and 5 men. The average age was 55.8 years (range 33–76 years). 6 patients had proven increase signal on MRI scan the rest were mainly clinical diagnosis and after a limited response to steroid injections. Their VAS improved from 10 to 5. Their post-treatment HOOS score averaged 255.

Of the 6 patients who had MRI proven increased signal 5 patients had significant improvement. The average improvement in the VAS was 10 to 2.3 and their HOOS scores were 349.2 (range 427–243).

Conclusion: Though the number of patients in this study is only 22 it seems that radial shockwave therapy treatment for trochanteric bursitis is promising, especially on those who have got high signal on MRI scans.


R Malhotra V Kumar

Introduction: There has been an introduction of short femoral stems with the aim of conserving bone. We present the short term results of short metaphyseal cement-less stem(Proxima®, Depuy).

Material and methods: 25 patients in age group (25–40yrs), 15 males,10 females were implanted with a short metaphyseal cementless stem (Proxima®, Depuy) and cementless acetabular cup. The average follow up was 2.3 years (1.4–2.5 yrs). Clinical evaluation using Harris Hip Score, Radiological evaluation and Bone Mineral Density were evaluated at 2weeks, 6 months, 12 months and yearly thereafter. a new zonal method suitable for short stem was used for radiological evaluation.

Results: The mean Harris Hip score improved from 44 to 95 at final follow up. There was no evidence of any radiolucent lines or osteolysis around the stems. All the stems showed evidence of osseointegration at one year follow up. There was no decrease in bone mineral density around the stems.

Discussion: The Short Metaphyseal cementless femoral stem is a bone conserving as well as bone preserving option for young patients especially in those in whom surface replacement is not an option.


M Rookmoneea A Khunda A Mountain A Hui

Introduction: Previous studies have demonstrated the value of the tip-apex distance (TAD) and the location of the screw in the femoral head in predicting cut-out. Similarly surgeons’ volume has been shown to affect mortality and morbidity in various surgical specialties, including in trauma and orthopaedics.

Aim: To determine whether re-operation due to cut out at six month can be predicted using TAD, location of the screw and fracture type; and whether the experience of the surgeon is important.

Methods: Logistic regression was used to analyse data collected retrospectively from 241 patients with extracapsular fractures (Jensen’s modification of Evans’ classification: Class I – 90, Class II – 93 and Class III – 58), treated with a dynamic hip screw, classic hip screw or intramedullary hip screw from April 2005 to October 2007.

Results: There were 7 cut outs (2.5%) requiring re-operation within 6 months – 1 in the consultant group and 6 in the trainee group,. The model used was statistically significant (X2=23.6 [13df], p< 0.05). The tip-apex distance was a strong predictor (p< 0.05) of cut-out requiring re-operation at six months. The odds of the patient requiring re-operation due to cut out increases by a factor of 1.2 for each millimetre increase in the TAD. Location of the hip screw and fracture type were however not significant predictors. The first surgeon was a consultant in 54 cases and trainee in 187 cases. There was no statistically significant difference in re-operation rate due to cut out between patients operated on by consultants compared to trainees.

Conclusion: The TAD is a strong predictor of cut out requiring re-operation at 6 months. No difference was found in our series in re-operation rate due to cut out among cases performed by consultants compared to trainees.


V Kumar R Malhotra S Bhan

Background: Joint replacements are being performed on ever younger patients at a time when average expectancy of life is continuing to rise. Any reduction in the strength and mass of periprosthetic bone could threaten the longevity of implant by predisposing to loosening and migration of prosthesis, periprosthetic fracture and problems in revision arthroplasty.

Aims & Objectives: This study aims to analyse and compare prospectively the femoral periprosthetic stress-shielding around 4/5th and 1/3rd porous coated cementless femoral stems in patients undergoing unilateral cementless total hip replacement done using DEXA scan by quantifying the changes in bone mineral density around femoral component.

Material & Method: Femoral periprosthetic bone mineral density was measured in the seven Gruen Zones with DEXA scan at 2 weeks, 1 years and 2 years after surgery in 60 patients who had undergone unilateral cementless total hip replacement, of which 30 patients had been implanted with 4/5th porous coated stems and other 30 patients with 1/3rd porous coated stems.

Results: At both one and two years postoperatively, bone loss due to stress-shielding was seen in both stems with maximum loss in zone VII and minimum in zone III, IV, V. The maximum mean percentage bone mineral density loss in 4/5th porous coated stems in zone VII was 16.03% at one year and 22.42% at 2 years as compared to loss of 10.07% and 16.01% in 1/3rd porous coated stems. Increased bone loss was seen in patients who had larger diameter stem (> 13.0 mm) and in patients with low bone mineral density in the unoperated hip.

Conclusion: Bone loss as a result of stress-shielding is more pronounced in 4/5th porous coated stems as compared to 1/3rd porous coated stems.


AS Desai TN Board

Leg length discrepancy (LLD) following total hip arthroplasty (THA) is a well-known and documented phenomenon. LLD can pose a substantial problem for both the patient and the surgeon. Patient dissatisfaction with LLD after THA is the most common reason for litigation against orthopaedic surgeons. Failure to restore limb length may lead to an unstable hip, whereas over-lengthening may cause low back pain, sciatic nerve palsy and early mechanical loosening.

Several intra operative techniques both invasive and non invasive have been reported in the literature to over-come LLD during THA. The accuracy of all the methods that measure from pins anchored into pelvis to point on the greater trochanter may be affected by the inherent variability of the leg position when measurements are made. Bending or dislodging the pins and using of calliper devices can be cumbersome during the THA surgery and can compromise the measurements.

Hence we describe a simple, safe and reliable intra operative technique to overcome LLD by using a stout braided suture material tied to the stout Judd pin used to retract the soft tissues in posterior approach. Utilising the routine incision for the posterior approach to the hip, this technique can be easily carried out in primary THA surgery as compared to other techniques used to avoid LLD, which require further incision, and specialised equipment which are time consuming, cumbersome and may not be very secure. This technique of using a suture mark over the Judd pin is simple, inexpensive and easily adaptable.


B Derbyshire PR Kay ML Porter

Introduction: “Force-closed”, tapered, polished, collarless stems, (e.g. C-stem, Exeter), are designed to subside in response to a gradual expansion of the cement/bone complex.

Above a certain threshold, distal migration may predict medium-to-long-term failure of “shape-closed” (collared, textured) stems. However, no such threshold exists for “force-closed” stems, and these may continue to migrate after 3 years. We believe that the tendency towards stabilisation 2–3 years postoperatively could be the best predictor of good long-term performance.

Method: Twenty OA patients (12F, mean age 66.6 years) were recruited for primary hip replacement with beaded C-Stem femoral components. Tantalum marker beads were injected into the proximal femur, and stems were inserted using CMW1 cement and the latest generation cementing technique via: a posterior approach (17), and a lateral, trochanteric approach (3). RSA X-ray examinations were performed at 1 week, 6 weeks, and at 3, 6, 12, 24 and 36 months postoperatively. The UmRSA system was used to measure and analyse the radiographs.

Results: By 36M the mean stem subsidence (1.05 mm) had levelled off to a low rate, and the mean internal rotation (2.5°) had not significantly changed during the final year (p = 0.08). The mean posterior migration of the stem centroid was 0.54 mm and posterior migration of the femoral head was 1.66 mm (0.25 mm/y during final year).

Discussion: At 36M the mean subsidence rate was very low, and the mean posterior migration was about one third of that reported by Sundberg et al. (BHS Meeting, 2007). Although the mean internal rotation was greater than that reported for the Exeter stem, it had stabilised during the final year. These low rates of migration at 3 years are consistent with the good results found in clinical studies of this femoral component.


MSA Couch JL Carson P Griffiths M Barrett S Scott

Introduction: Modular prostheses were first developed for use in total hip arthroplasty (THA) in the 1980s as a potential solution to the problem of leg length inequality. There is much literature discussing the advantages and disadvantages of modularity in THA but there are few studies directly comparing modular and non-modular prostheses and their accuracy in restoring normal anatomy. Our aim was to assess whether modularity in THA improves the restoration of femoral offset and leg length.

Methods: An analysis of post-operative radiographs of 76 patients who underwent THA - 38 using modular and 38 using non-modular prostheses was undertaken. The femoral offset and leg length of the operated and un-operated hip were measured for each patient. Inter-and intra-observer errors were reduced to a minimum. A two-tailed T test was then applied to the data.

Results: Restoration of leg length (to within +/− 10mm of the un-operated hip) was achieved in 81.6% of patients in the non-modular group, compared to 78.9% in the modular group (p=0.60). On average, the modular system increases leg length of the operated hip by 0.64mm compared to the non-modular system, which reduces leg length by 3.76mm (p=0.016). The femoral offset is restored to within 5mm of the un-operated hip in 60.5% of modular THA and in 55.3% using a non-modular prosthesis (P=0.48). On average, modular prostheses increased offset by 0.85mm and non-modular prostheses by 0.15mm (P=0.64).

Discussion: The modular and non-modular hip prostheses are equally successful in achieving restoration of leg length and femoral offset to the pre-pathological state.


R J Macfarlane S Hadi M Binns

Introduction: Trochanteric bursitis (TB) in association with increased femoral offset components in THA has not previously been reported. We report 15 cases of postoperative TB, all of whom were noted to have high offset femoral implants. Increasing awareness of this complication when inserting femoral components is an important consideration for the arthroplasty surgeon, emphasizing the need for preoperative templating.

Methods: We retrospectively reviewed casenotes and postoperative radiographs patients attending outpatients following THA, with lateral hip pain. A diagnosis of trochanteric bursitis was made in individuals complaining of lateral hip pain, worse on exercising, and tenderness over the trochanter. The presence of a high offset femoral component was noted from casenotes radiographs. Patients with pre-existing TB, recent local trauma, or inflammatory disease which may contribute to TB, were excluded.

Results: 15 cases were identified in a 3 year period. Female to male ratio 1.3:1. The mean age was 68 yrs with a range of 54–81yrs. 7/15 cases (46%) underwent posterior approach to the hip, 8/15 (54%) underwent a Hardinge lateral or modified lateral approach. All patients had clinical features of TB at first postoperative follow up. Mean time to onset of symptoms was 7.2 months, range 2–12 months. All femoral implants had 5mm offset or greater. Postoperative X-rays showed a mean increase in offset of 10.2mm, range 3–18mm.

Discussion: The results indicate that an increase in femoral offset may increase a patient’s risk of trochanteric bursitis, following THA. The data suggest the operating surgeon should consider carefully the use of increased-offset implants, particularly in those at a higher risk or TB e.g inflammatory disorders. This study emphasises the importance of preoperative templating in total hip arthroplasty.


FA Shah JD Moorehead SJ Scott

Introduction: Leg length discrepancy (LLD) following hip arthroplasty can produce abnormal loading leading to pain, increased wear and loosening of implants. The aim of this study was to investigate the relationship between LLD and static limb loading.

Methods: A pedobarograph was used to measure the limb loading of 19 normal volunteers aged 18 to 58. Each volunteer was asked to stand on the Pedobarograph with both feet so that their weight could be recorded. The load through the left leg was then recorded with the right leg on a platform level beside it. The platform was then raised in 1 cm increments to 6 cm, to simulate different levels of LLD. In each position 3 readings were taken with the right knee flexed (pelvis level), and straight (pelvis tilted).

Results: When the feet were level the left leg took 53 % of the load. As the height of the right foot was increased the load through the left leg increased in a non-linear fashion.

With the knee flexed, a 1 cm difference produced a 3 % increase in loading. This was significant (P< 0.05). All subsequent increases were also significant. The largest increase in load was observed between 1 cm & 2 cm (+5 %). At 6cm the left leg load was 70.9 %.

With the pelvis tilted, there were smaller increases in loading. These did not become significant until a difference of 5 cm. The maximum load was 62.1 % at 6 cm.

Discussion: The length-loading relationship was non-linear. The pelvis tilted stance produced less loading asymmetry, but more discomfort than the flexed knee stance.


K Periasamy S Spencer S Patil A Mohammed H Murray WS Watson RMD Meek

Introduction: The ideal acetabular component has low wear, permanent fixation and physiological bone loading. Recently trabecular metal has been promoted as reproducing the modulus of trabecular bone with a cementless fixation. The aim of this trial was to see if a monobloc trabecular backed polyethylene acetabular component loaded the pelvis physiologically as a cemented polyethylene component.

Method: Between 2004 and 2006 54 patients were ran-domised to a cemented polyethylene acetabular component versus a monobloc trabecular backed polyethylene acetabular component. The primary outcome measurement was bone density in peri-prosthetic acetabular regions of interest measured preoperatively and post operatively at 6 weeks and 1 year. Secondary outcomes measured were radiographic and functional outcomes (HHS and Oxford score).

Results: Radiographically 8 patients in the trabecular group had a significant gap in zone II which resolved in 6 by 1 year. The cemented group had 3 patients with a radiolucent line (zone 1) at 1 year. HHS and OXFORD scores improved with no significant difference between the groups. Both groups had significant loss of bone density in the ilium and ischium. The trabecular group produced a significant increase in bone density in the superolateral region. The cemented group produced increased bone density in the superomedial region.

Discussions and Conclusions: There is a significant reduction in BMD for both groups in the upper pelvis and ischium in keeping with finite element modelling predictions. The press-fit group relative to the cemented group resulted in decreased BMD in the superomedial peri-prosthetic region. The trabecular monobloc cup therefore behaves more like a rigid cementless shell despite the properties of trabecular metal.


G Antoniades S Wearing A Deakin M Sarungi

Introduction: The geometry of uncemented press-fit ace-tabular cups is important in achieving primary stability to ensure bony ingrowth. This study compares the in vitro primary stability of two widely used designs.

Methods: The primary stability of two uncemented ace-tabular cup designs (true hemispheric and peripherally enhanced) with the same 52mm diameter and produced by the same manufacturer, was tested in vitro. Polyethylene blocks of low and high density -representing softer and harder bone- were reamed using the manufacturers’ reamers. The cups were seated using an Instron 5800R machine. Peak failure loads and moments during uniaxial pull-out and tangential lever-out tests were used as measures of primary stability. Eighty tests were performed.

Results: Low density substrate: no difference between the two designs for seating force or stability, with the substrate under-reamed by 2mm.

High density substrate: the cups could not be adequately seated with a 2mm under-ream. Seating was achieved with 1mm under-ream for the hemispheric and 1mm over-ream for the peripherally enhanced design. There was a statistically significant difference in seating forces, with the hemispheric cup requiring less force (6264±1535N vs 7858±2383N, p< 0.05). There was a statistically significant difference in the stability ratio of pull-out force to seating force, favouring the hemispheric cup.

Discussion: No difference was seen in the low density substrate between the 2 cups.

In the high density, the hemispheric design had better characteristics (lower seating force and higher pull-out force to seating force ratio) than the peripherally enhanced design, which are more favourable in clinical settings.


AP Cooper L Prtak R Townsend SC Buckley

Introduction: Direct exchange of total hip arthroplasty as a single stage revision procedure for aseptic loosening represents a significant proportion of the revision surgeon’s case load, accounting for 38% of cases in the Sheffield Lower Limb Arthroplasty Unit. In our unit current practice is to obtain preoperative negative hip aspirates and normal inflammatory markers and take 5 intraoperative deep tissue samples for microbiological culture. The aim of this retrospective, observational study was to evaluate the necessity of this technique.

Method: 100 consecutive direct exchanges to total hip replacements for aseptic loosening performed in our unit between 03/10/2005 and 31/07/2007 were identified using the arthroplasty database and their case notes reviewed. The microbiological results were evaluated by a microbiology consultant and the notes were examined. A minimum of 1 year follow-up was obtained in all patients.

Results: 42 patients were found to have one or more positive sample. Of these 37 were deemed by the microbiologist to be contaminants and 5 to have a significant growth. Of the 5 with significant growth, 2 patients were treated with systemic antibiotics as a result of microbial tissue sample growth. At the latest follow up appointment (range 22–33 months) these 5 patients were all clinically not infected.

Conclusion: The practice of obtaining routine deep tissue samples is essential for revision surgery performed for aseptic loosening. 5% of patients in our series had a significant bacterial growth despite being presumed to be aseptic which would otherwise not have been detected. The support of a microbiologist with dedicated arthroplasty interest is vital in determining the relevance of sample results.


S Rajkumar S Tavares

Introduction: We undertook a questionnaire study to assess the compliance with DVT prophylaxis following lower limb arthroplasty surgery and evaluate reasons for non-compliance (if any).

Method: Following joint replacement surgery, 50 patients (45 had THR, 5 had TKR) were asked to fill in anonymised questionnaire at 6 weeks. They were asked about awareness for DVT, information given, prevention methods, duration and type of prophylaxis given and their compliance with treatment.

Results: Most of the patients (45) were aware of the risk of DVT while 2 were not aware and 3 were not sure. 37 patients were given information during their clinic visit while 7 did not receive any information and 6 can’t remember. 32 patients remembered discussing risk of developing DVT while 9 did not and 9 were not sure. 34 patients (68%) were aware of prophylactic methods. Except for 2 patients, the rest 48 patients (96%) confirmed receiving prophylaxis. 48 patients (96%) had mechanical prophylaxis in the ward while 6 continued at home as well. 46 patients (92%)remembered receiving chemical prophylaxis both in the ward and at home thereafter.

36 patients received chemical prophylaxis (injections) for 10 days, 5 for 7 days, 8 for a few days and 1 patient for 6 weeks post-op. 38 patients (76%) self administrated the injections while 6 had family members help and 3 had district nurse visit. 47 patients (94%) received injections for the complete duration. 3 patients did not receive injections regularly at home (missed nurse visit – 1, not advised – 1, forgot to inject – 1).

Discussion: DVT compliance is still an issue in surgery especially when patients were asked to self-administer the injections. We achieved 94 % compliance with our protocol. This study shows that greater emphasis on patient education, awareness and motivation may help improve compliance.


Full Access
N Bali P Leggetter R Sidaginamale P Pynsent D Dunlop A Pearson

Introduction: The Corail stem is a well proven femoral implant used for the past 22 years. It is the most common uncemented femoral stem used for total hip replacements in the UK. The stem was modified in 2004 with an increased neck taper to allow for an increased range of bearings and modular heads. This study reviews a series of primary total hip replacements using this recently modified Corail stem to assess if this implant is still performing to acceptable standards.

Method: A prospective patient database collated by 2 arthroplasty surgeons recorded data at the time of operation and subsequent follow up. All intra-operative and post-operative complications were recorded. Pre and postoperative oxford hip scores were analysed.

Results: 751 cases were reviewed. The average age was 63 with females accounting for 69%. The pinnacle cup was used in 83% of cases, with a polyethylene bearing in 48%. Survival of the stem at 3 years was 99.9% (1 periprosthetic fracture following a fall), the cup 99.6%, with overall survival of 99.5%. The most common intra operative complication was calcar fracture occurring in 0.9%. Dislocation occurred in 0.5%, subsidence in 0.3%, deep infection in 0.1% and leg length discrepancy requiring shoe raise in 0.1%. Average 3 year oxford hip score was 12.

Discussion: 3 year survival of both the femoral stem and the total hip replacement are above the quoted rates in the National Joint Registry’s 4th annual report for corail and uncemented stems (98.8% and 98.1% respectively), and also exceeds that of cemented stems (99.1%). The same report quotes similar rates of calcar fractures (0.8%), although we recorded no other perioperative complications. We conclude the new generation of Corail stem has excellent 3 year performance.


PE Coyne R Tate PA Banaszkiewicz

Introduction: Intra-articular injection (IAJ) with cortico-steroid and local anaesthetic has been used as both diagnostic and therapeutic intervention in osteoarthritis of the hip. Doubt remains about its efficacy in confirming the source of symptoms in patients with both hip and spinal arthritis. There are also concerns about the introduction of infection for patients undergoing surgery.

Methods: All patients undergoing Hip IAJ for osteoarthritis within a 6-month period in 2007 were reviewed for three surgeons at one institution retrospectively. Data was collated and analysed using a set protocol allowing 18 months follow-up period.

Results: 41 procedures (38 patients) had injections within the study period. Male: Female ratio was 17:24. Average age was 52 years. There were 54% right-sided procedures.

25/41 patients had full response to the injection. 80% were listed for surgery as a result (documented reasons in those not listed). 6/41 patients had a partial response to the injection – 66% were managed conservatively (due to co-morbidities elicited at review, or spinal pathology). 10/41 patients had no benefit – 3 were offered surgery (one after MRI confirmation, one after prolonged physiotherapy and one after discussion about diagnostic overlap).

Hip replacement completely reduced symptoms in 19/21 (90%) and partially in 2/21 (10%) (1 had undergone a successful pre-operative IAJ).

There were no deep infections in patients undergoing surgery after injection. 1 patient had a superficial infection (resolved at review).

Discussion: Diagnostic IAJ can be of value in patients when there are concerns whether the origin of symptoms is truly ascribable to the hip. Patients where injections are successful go on to undergo successful surgery without an increased risk of infection.


C Kabir N Sandiford J Hua J Skinner S K Muirhead-Allwood

Introduction: One of the most important factors affecting the outcome of revision THR of the femoral stem is the variability of femoral endosteal geometry after removal of the in-situ stem. A custom made implant would greatly reduce the inventory of the ‘Off the shelf” (OTS) components. This study presents the medium to long-term results of a cohort of patients with this revision prosthesis.

Methods: During the period November 1991 to November 1998, 158 patients were implanted with a computer-assisted design and computer-assisted manufactured (CAD-CAM) revision prostheses (Stanmore Implants Worldwide, Biomedical Engineering Unit, RNOH) by the senior author (SMA). There were 97 males and 61 females. The average age was 63.1 years (34.6 – 85.9). The indications for revision surgery were aseptic loosening (135 cases, 85.4 %), peri-prosthetic fractures (6 cases, 3.8 %), infection (12 cases, 7.6%) and liner wear (3 cases, 1.9%).

Results: At 10 years all patients reported relief of pre-operative pain and the average hip flexion was 95o (90 o –110o). Oxford, Harris and WOMAC hip scores in the pre-operative and post-operative period were 41.1, 44.2 and 52.4 respectively and 18.2, 89.3 and 12.3 respectively (p< 0.0001, p< 0.0001, p< 0.0001).

There were 6 complications (3.8%) in this series; a periprosthetic fracture of the femoral diaphysis (1), posterior dislocation (2), failure secondary to aseptic loosening of the implant (1) and deep vein thromboses (2)

Discussion: These ten year results are encouraging and suggest that there is a role for the use of custom implants in revision THR, particularly where the anatomical variance of the proximal femur makes the use of OTS implants unsuitable.


P Vaughan P Johnston G Keene

Introduction: Serial reamers of incremental diameter are used in the preparation of the acetabulum in Total Hip Arthroplasty. If the reamer is blunt then the size of the reamed acetabulum may not accurately represent the size of the last reamer used. This inaccuracy may then adversely affect implant selection or implantation.

Methods: Traditional debris-retaining cheese grater ace-tabular reamers were used to create a cavity in a foam block, following a standardised technique. A casting was then made of the cavity, the diameter of the cast measured and compared to that of the reamer. Accuracy was defined as the difference between the observed and expected diameters. Measurements were collected for five different hip systems (78 reamers in total)

Results: Sixty-four out of the seventy-eight reamer tested were inaccurate. There was a significant difference between groups. Only reamers from one of the five systems tested consistently created cavities which accurately matched their stated size. Two systems consistently produced a cavity that was at least 1mm smaller than intended. In the majority of cases the mid-range reamers, sizes (46–52mm) were the most inaccurate.

Discussion: The majority of acetabular reamers in our study were inaccurate. If this is unintentional, it suggests reamers may become increasingly blunt with use and should be calibrated, sharpened or replaced.


N.A. Sandiford C. Kabir S.K. Muirhead-Allwood J. Skinner

Introduction: While the explant device has made revision of uncemented acetabular components technically easier, the unique design of the Birmingham Hip Resurfacing(BHR) acetabular component precludes the use of the standard explant extractor. The dual radius geometry of this socket causes impingement and damage to the curved blade of this device.

A novel adaptor was designed to correct for the differential radii and enable removal of the well fixed BHR socket with the explant. We present the results of our initial experience with this device.

Method: A prospective study was performed to evaluate the effectiveness of this device for revising the well fixed BHR socket. All cases were performed by a single surgeon via a posterior approach.

The explant cup extractor was used with its standard centering head and curved blades. The size of the explanted cup, last reamer size and size of the implanted component were recorded

Results: Three males and 7 females were included. Their average age was 58.1 years (48–65). Average time to revision of the BHR sockets was 24.2 months (7–40). Average explanted cup size was 51mm (46–58) and final reamer size 53.8mm (51–59). Average final socket size was54.8 (50–62). Overall there was a mean 2.8.mm size difference between the explanted cup and the final reamer.

Discussion: The thickness of the blade of the explant was 2mm therefore only 0.8 mm of bone was lost on average. The device enables a simple reproducible removal of the well fixed BHR sockets with preservation of acetabular bone stock.


C Kabir G Stafford J D Witt

Introduction: We present the results of a prospective study of the blood transfusion requirements in patients undergoing a Bernese periacetabular osteotomy (PAO) with the use of an intra-operative cell-saver and without pre-donated blood. These data were compared with an earlier audit of patients who underwent this procedure without use of a cell saver.

Material and Methods: A cohort of 50 patients (56 hips) underwent a PAO for hip dysplasia between December 2006 and November 2008 performed by the senior author. The average age was 29 years (17–51) and there were 38 females and 12 males. The average weight was 69.96 kg (46–110) and the mean duration of operation was 136 minutes (100–240). A cell saver (Fresenius-Hemocare, Germany) was used intra-operatively for this cohort. Pre-operative Hb, post-operative Hb taken the day after surgery and any units transfused were documented. A post-operative transfusion policy was adopted where a haemoglobin (Hb) concentration of < 7.5 g/dl was an indication for transfusion or where a patient was sufficiently symptomatic

Results: The mean pre-operative Hb was 13.60 g/dl (10.8–15.9) and the mean post-operative Hb was 9.91 g/dl (6.4–11.8). Overall 4 patients received post-operative allogenic blood transfusion; 3 patients receiving one unit and one patient receiving 2 units. No patients received intra-operative allogenic blood.

Conclusion: Compared to our previous audit, the use of the cell saver resulted in an improvement in the mean post-operative Hb, (9.2 g/dl compared to 8.0 g/dl). The transfusion rate was also reduced (7.27% compared to 10.8%)..


A. Gordon AJ. Hamer I. Stockley R. Eastell JM. Wilkinson

Introduction: Polymorphisms within genes encoding bone regulatory cytokines influence individuals’ susceptibility to osteolysis after THA. We aimed to determine whether single nucleotide polymorphisms (SNPs) within these genes influence the severity of these osteolytic lesions in 272 patients with established aseptic loosening.

Methods: Assessment of osteolytic lesions was made from pre-revision radiographs in conjunction with direct visualisation in those subjects undergoing surgery. Osteolytic lesions were defined as linear (AAOS pelvic and femoral osteolysis classification grade 0) or expansile, in the presence of segmental or cavitary defects (AAOS grade 1 or greater). We analysed 11 SNPs in the pro-inflammatory cytokines IL-1A, IL-1B, IL-1RA, IL-6 and TNF; 2 SNPs within the FRZB gene, which modulates osteoblast function; and 6 SNPS in the RANK/RANKL/OPG pathway, that modulates osteoclast function.

Results: Femoral Osteolysis: Carriage of the IL-6 −174C allele was 60% in the expansile osteolysis group versus 80% in the linear osteolysis group (χ2 test p=0.007). Carriage of the OPG −163G allele was 34% in the expansile osteolysis group versus 18% in the linear group (χ2 test p=0.03). The odds ratios for expansile osteolysis associated with carriage of IL-6-174G and OPG −163G were 2.7 (1.3 to 5.7, p=0.008) and 2.3 (1.1 to 5.0, p=0.03) respectively.

Acetabular Osteolysis: No differences in SNP genotype were found between osteolysis groups.

Discussion: The IL-6-174G allele and the OPG-163G allele are over-represented in subjects with expansile femoral versus linear osteolysis, but do not relate to severity of pelvic osteolysis. These differences in association may reflect differences in the mechanism of osteolysis between the bone sites, however, replication of the results are required to confirm this differential association.


AS Desai A Dramis M Agarwal TN Board ML Porter

Introduction: Total hip replacement (THR) in young patients is a controversial subject due to high failure rates reported in the literature. The purpose of this study was to show our short term results of primary total hip replacement in patients younger than 30 years of age.

Methods: Patients who underwent THR prior to the age of 30 years between 1998 and 2007 were identified and records of all patients were reviewed together with the radiographs till the last follow up.

Results: Forty three THRs were performed on 36 patients with an average age of 24.4 years (range, 17–30) and an average follow up period of 47 months (range, 7–109 months). There were 5 cases of Juvenile chronic arthritis, 2 Rheumatoid arthritis, 11 DDH, 2 septic arthritis, 1 pseudoachondroplasia, 4 Perthes disease, 2 seronegative arthitides, 2 SUFE and 7 AVN [alcohol, leukaemia, fracture, SLE (2), mannosidosis, idiopathic].

Thirty cemented THRs and 13 hybrid THRs were performed through trochanteric osteotomy approach (23), posterior approach (17), Hardinge approach (2) and anterior approach (1). In the cemented group there were 3 cases of superficial wound discharges, 1 recurrent dislocation, 1 complete femoral nerve palsy, 2 cases of neuropraxia and 1 case with persistent hip pain but no cases of infection. In the hybrid group there was one case of partial femoral nerve palsy. None of the patients has undergone any revision surgery till the latest follow up. Radiologically only one case showed aseptic loosening in both femoral and acetabular components, which is not revised as the patient is asymptomatic.

Discussion: THR is an elegant procedure and should be certainly considered in young patients suffering with disabling arthritic conditions affecting the hip joint. Our results show that THR - both cemented and hybrid types - is a successful and durable treatment.


DJ Langton TJ Joyce SS Jameson AVF Nargol

Background: There is a paucity of published literature with regard to metal ion levels following bilateral hip resurfacings.

Method: Recent research has identified femoral component size and acetabular cup anteversion and inclination as important variables involved in metal ion release into the blood. We compared 13 patients with bilateral joints resurfaced using the ASR and 11 patients with bilateral BHRs to those with unilateral joints of similar size and cup inclinations/anteversions. Patients were excluded if the last procedure was within 12 months of blood sampling and if they had other metallic implants. Analysis of standing radiographs to determine cup orientation was carried out using EBRA software. Blood samples were analysed using ICPMS.

Results: Median whole blood Cr and Co values were higher in the BHR bilateral group when compared to the unilateral BHR group by a factor of 1.12 and 1.24 respectively. (5.17 vs 4.59 for Cr, 2.40 vs 1.93 for Co). The difference was significant for Co (p=0.030) but not for Cr (p=0.136). For the large ASR joints (53mm), median Cr and Co values were higher in the bilateral group by a factor of 1.5 and 1.85 respectively. (4.55 vs 2.97 (Cr) 2.83 vs 1.53 (Co)). The difference was significant for both Cr (p=0.001) and Co (p=0.022). For the small ASR joints (< 53mm), median Cr Co values were higher in the bilateral group by a factor of 1.95 and 2.30 respectively. (8.29 vs 4.25 (Cr), 6.78 vs 2.94 (Co)) (p=0.019 Co) (p=0.007 Co).

Conclusion: Metal ion concentrations are significantly greater in patients with bilateral resurfacings. The Cr Co concentrations observed in our patients with bilateral small ASR joints are double those in the published literature on bilateral 28mm metal on metal(MoM) joints implying that the lubrication achieved by small ASRs is sub optimal.


S.J. Parsons I. Starks G. Bancroft C. Baker P.J. Roberts

Introduction: The national comparative audit in 2007 of blood use in primary elective hip replacement, showed a 25% transfusion rate. Of those 93% received two or more units. Orthopaedic surgeons are large users of blood, so reducing blood use, should save costs and reduce risk from unnecessary donor exposure.

Methods: Over two years 221 consecutive primary total hip replacements were performed, on 84 male and 137 female patients, average age 70 years (42–91yrs). For each the Haematinics cell salvage system was used. Throughout the surgery the cell salvage system was used. At the end of the operation all swabs were washed, the washings were salvaged. Iodine/peroxide contaminated washing and swabs were discarded.

Results: Were we using blood at the level suggested by the comparative audit, 55 patients would have received an average of 2.4 units (132 units total). The actual number of patients transfused was 12, receiving an average of two units (24 units total). This is 108 units less with 43 fewer patients receiving allogenic blood. Using a test of proportions using the Normal distribution then the significance probability is extremely small (SP< 0.001) indicating that this group of patients had a significantly smaller number of transfusions than would be expected compared with the National Average. The transfused patients were older (78.9 vs. 69.8, p< 0.01), had a greater Hb drop (45 g/l vs. 31.2 g/l, p< 0.01), had a lower pre-op Hb (121.3 g/l vs. 138 g/l, p< 0.001), and a greater length of stay (12.8 days vs. 5.8 days, p< 0.05). Gender was not significant.

Discussion: Using the cell salvage system leads to a significant reduction in allogenic blood use. It may not be cost neutral once the use of disposables is factored in, but may represent a useful tool to cost effectively reduce allogenic blood use.


TN Board WL Walter

Introduction: Acetabular cup inclination is associated with higher wear in both UHMWPE and ceramic-on-ceramic hips. It has also emerged recently as a critical factor in the success of hip resurfacing. A direct correlation between socket inclination and serum metal ion levels has been demonstrated and concerns remain regarding edge loading and hypersensitivity. Resurfacing socket designs vary and manufacturers do not recommend specific inclination angles for their products. The aim of this study was to investigate the effect of cup geometry on the effective inclination for a variety of different designs of resurfacing socket.

Methods: The internal geometry of every available size of Birmingham Hip Resurfacing(BHR-Smith & Nephew), ASR(DePuy) and MITCH TRH(Stryker) socket was measured using X-ray templates. This data was used to calculate the difference between the apparent inclination and the true inclination for all sockets.

Results: BHR and MITCH TRH cups have lateralised internal geometries in that the centre of the internal surface is lateralised by 3.5mm in the case of the BHR and varies from 2 to 3.8mm in the MITCH TRH system. The ASR is concentric but the bearing surface is less than a hemisphere and there is also an internal groove which further reduces the bearing surface. The difference between apparent and true inclination was greatest in the ASR socket (13o–18 o) followed by the BHR (7o–10o) and then the MITCH TRH (6o–8o). This difference increased with decreasing socket size in both the BHR and ASR but was more or less constant in the MITCH TRH.

Conclusion: These results show that a socket measured at 45o of inclination may have a true inclination of up to 63o. This has important implications for surgeons who should have full knowledge of the design geometry of the socket being implanted and adjust the inclination angle accordingly.


LK Smith MC Parry MJ Barakat RF Spencer

Introduction: Of all hip arthroplasties conducted annually, a proportion will subsequently require revision for aseptic loosening and periprosthetic osteolysis. Osteolysis may develop ‘silently’ and monitoring of patients is recommended. This should include x-rays as progressive changes in size of a lesion may indicate a potential failure. Area measurement of osteolysis has been achieved in a number of ways but with techniques that are not readily available in routine clinical practice. The aim of this study was to develop a method for routine assessment of hip arthroplasty to quantify osteolytic changes seen on x-ray, applicable by any health professional and with good inter-observer reliability.

Methods: A morphometric grid is superimposed on an object of interest and the number of test points that fall within a defined area counted. A specialized grid was developed and initial testing was conducted on twenty simulated osteolytic lesions. Subsequent testing was on thirty-five arthroplasty x-rays with evidence of osteolytic lesions. Four observers recorded the number of crosses seen over each lesion. The observers were representative of health professions and levels of experience involved in arthroplasty review.

Data was analysed for both inter-observer and test-retest reliability using the intra-class correlation coefficient and the Bland-Altman method (use of two methods provides a better estimation of accuracy).

Results: The results for intra-class correlation coefficients on both simulated and actual lesions were all excellent (range 0.90 to 0.98) as confirmed by visual representation using the Bland-Altman method.

Discussion: Regular follow-up of hip arthroplasty with x-ray ensures that changes are monitored even when symptoms are absent. We believe that this tool can improve the process through quantitative assessment of osteolytic lesions. The scientific development supports the reliability of the tool when used by a number of raters and the simplicity of application makes it a useful addition to an arthroplasty clinic.


O Grant P Diggory P Fadero G Howell F Kashif G Nunn

Introduction: It is well established that prompt medical management and early surgery for patients with fractured neck of femur has been shown to reduce mortality and reduce hospital length of stay. A Trauma Pathway Group (TPG) was established at Mayday Hospital, in August 2007 to assess local practises and to implement improvements, led by senior clinicians in Orthopaedics, Anaesthetics and Orthogeriatrics, and liaising with senior hospital managers within the trust. Here we present results after one year of the TPG.

Means and methods: We reviewed all patients admitted to Mayday with a fractured neck of femur over 60 years of age at admission between 1st October 2006 and 31st September 2007 (prior to the TPG) and between 1st October 2007 and 31st September 2008 (after the TPG).

We compared these two groups, focussing on pre-operative delays, length of stay in hospital and in-hospital mortality.

Results: There were 185 patients admitted to Mayday University Hospital between 1st October 2006 and 31st September 2007, and 212 between 1st October 07 and 31st September 2008. The average age of patients admitted was 83. 75% were female. There was no significant difference in mean age or sex between the two groups. The mean wait for surgery was reduced from 4.3 days to 1.3 days (p< 0.001). The mean length of stay was reduced from 33.5 days to 26.2 (p< 0.005). The in-hospital mortality was not significantly altered - 14.6% in the first year, and 16.0% in the second.

Discussion: The TPG has had a significant impact on the management of patients with fractured neck of femur. Our figures and feedback from staff and patients has been positive, and the work has increased the prominence of the care of these patients, so has enabled us to significantly improve the care of this extremely vulnerable group.


S Bhatnagar DJ Langton S Aval JP Holland AV Nargol

Background: Resurfacing cups may produce significant clinical problems when placed at the extremes of version, including increased production of metal debris and psoas tendonitis.

Methods: We obtained the femoral and acetabular components of two unused ASR (Articular Surface Replacement) and BHR (Birmingham Hip Resurfacing) devices. The components were placed in moulds at varying degrees of inclination and anteversion in a grid to simulate pelvic landmarks and AP radiographic images were captured. The true radiological anteversion was determined by rotating the x-ray beam so that it was perpendicular to the acetabular axis and measuring the angle subtended by the cup rim and the vertical axis.

Five blinded orthopaedic registrars then used EBRA (Einzel-Bild-Roentgen-Analysis, University of Inns-bruck, Austria) software to determine the radiological anteversion from the AP films. Twenty-five ASR and twenty-five BHR images were analysed.

At the same time each observer was asked to grade the cups as “1” (< 10°) “2” (10–20°) “3” (20–30°) or “4” (> 30°) depending on the appearances of the cup vertices.

Results: Mean error for each observer was −0.7 (minimum) to 1.6° (maximum). The range of standard deviations of error for each observer was +/− 2.2 (minimum) to 3.5° (maximum). Retroverted cups were not identified in the majority of cases.

Cups graded as “1” or “4” showed high sensitivity and specificity for the true grade as determined on the lateral radiographs.

Conclusions: EBRA software can be used to calculate the anteversion of resurfacing cups to a clinically acceptable degree. The clinician must be aware of the limitations of the software most notably the difficulty in identifying a retroverted cup and errors arising from poor quality radiographs in terms of pelvic rotation. The presented clinical grading system can be used as a rapid assessment tool to identify cups at the extremes of anteversion.


L M Jennings M Al-Hajjar I J Leslie J Fisher

Introduction: There is increasing interest in the use of ceramic on ceramic bearings for hip replacement, due to recognition of their extremely low wear and biocompatibility of the wear debris [1].

The aim of this study was to investigate the influence of cup inclination angle and head position on the wear of ceramic-on-ceramic total hip replacements.

Methods: The wear of Biolox Delta alumina matrix composite ceramic (CeramTec AG, Germany) was investigated using the six station Leeds II Physiological Anatomical hip joint simulator, using 25% bovine serum as a lubricant. Three ceramic-on-ceramic bearings were mounted with the cup providing a clinical angle of 55o (representing the standard condition) and three were mounted to provide a clinical angle of 65o (representing the steep cup angle condition). Simulator studies were carried out under standard gait conditions for 2 million cycles, and under micro-separation conditions for a further 3 million cycles. Micro-separation and dynamic lateralisation of the position of the head replicate head/cup rim contact at heel strike and simulate stripe wear on a ceramic femoral head as found on ceramic-on-ceramic retrievals [2]. Volumetric wear was determined gravimetrically and statistical analysis was performed using One Way ANOVA.

Results: There was no difference in the wear rates under standard gait conditions for the standard and steep cup angles, with a wear rate of 0.05 mm3/million cycles. Under micro-separation conditions the wear rates increased significantly to 0.13 and 0.11 mm3/million cycles for the standard and steep cup angles respectively. However, there was no significant difference between the standard and steep cup angle groups.

Discussion: Micro-separation and dynamic lateralisation of the position of the head during gait simulation significantly increased wear. However, the inclination of the cup in ceramic-on-ceramic THRs did not have a significant effect on the wear under either standard gait or micro-separation conditions.


P Thorpe S Duckett FA Carroll

Introduction: With recent concerns about the prevalence of Clostridium difficile, some Orthopaedic departments have changed their antibiotic prophylaxis for hip arthroplasty patients. Are these decisions evidence-based and are the changes in the best interests of the patient? We have gathered information from hospitals across the UK to investigate whether prophylactic regimens are changing and what is driving this change.

Methods: Information was gathered using a questionnaire. This was sent via e-mail to hospitals in the Mersey Deanery, the East Anglian Deanery and other hospitals across the UK.

Results: Replies were received from 21 hospitals in total. The vast proportion is still using cefuroxime 1.5g on induction with 2 post-op doses of cefuroxime 750mg. Those that have changed are mainly using flucloxacillin/gentamicin although decisions regarding prophylaxis are being driven by microbiologists/management (cost implicated in 10%) rather than clinicians/clinical evidence.

Discussion: The AAOS has recommended that antibiotics used for prophylaxis should be carefully selected. They should be consistent with current recommendations in the literature, taking into account issues of resistance and patient allergies. In 2007, the DoH recommended prudent antibiotic prescribing to reduce the use of broad spectrum antibiotics as an important component in preventing and controlling Clostridium difficile. Nelson postulated in a Cochrane Database Review in 2007 that in treating Clostridium difficile-associated diarrhoea in adults, teicoplanin appeared to be the best choice because evidence suggests that it is better than vancomycin for bacteriologic cure and has borderline superior effectiveness in terms of symptomatic cure. The combination of teicoplanin (covering Gram positive organisms including MRSA and enterococci) an gentamicin (covering aerobic Gram negatives and staphylococci) would surely be in the best interests of the patient despite the cost.


RP Sidaginamale P Leggetter N Bali P Pynsent DJ Dunlop

Introduction: The senior author undertakes single stage revision hip arthroplasty for cases with no preoperative evidence of infection based on history and examination, ESR and CRP results and negative results from selective aspirations. Despite this a large proportion of intra-operative samples are positive for infection. The purpose of our study is to look at the results of intra-operative histology and microbiology samples in these cases and to assess the subsequent incidence of infection.

Methods: Retrospective case study comprising of 230 single stage revision total hip arthroplasties carried out by a single surgeon over 5 year period (2003–2008). Intra-operatively tissue samples were taken from multiple sites and sent for both histology and microbiology. Microbiology results were reported at 24hrs, 48hrs, 7 days and 21 days and correlated with histology reports.

Results: From a total number of 230 patients, we had 98 left and 132 right hip revision arthroplasties. There were 95 men and 135 women with a mean age of 73 years (range 40–93). Intra-operative microbiology was negative in 108 patients (46.95%), of which 3 patients’ histology samples were consistent with infection. Of the 122 microbiology positive patients (53.04%), there were 8 histology samples consistent with infection. The most frequent growths were of Coagulase negative Staphylococcus (64 cases) and Propionibacterium (18 cases). 3 cases subsequently developed deep infection.

Discussion: This study highlights a significant discrepancy between intra-operative microbiology and intra-operative histology results. There is also a very high discrepancy between pre-operative assessment and intra-operative microbiological findings although the majority of cases subsequently did not show any clinical evidence of infection.


MC Rao SJ Phillips M Hemmady JP Hodgkinson

Introduction: Trochanteric osteotomy provides excellent exposure to perform hip replacement surgery. In the UK, 5.9% of primary hip replacements are performed using an osteotomy. Trochanteric non union is one of the complications of this approach. The aim of this study was to investigate the role of release of posterior trochanteric soft tissue release on the incidence of trochanteric non-union.

Method: We present the results of 100 patients who underwent primary cemented total hip replacement at our centre using the biplanar, intracapsular osteotomy. Group A (50 patients) had received a posterior trochanteric soft tissue release as part of the approach and Group B (50 patients) had not. Patients were followed up clinically and radiologically.

Results: In group A the trochanteric non union rate was 12% and in group B 2% (p< 0.05). According to the Hodgkinson’s classification of trochaneric non-union, all the non-unions in group A were grade 3 (> 1.5 cm migration) and group B was grade 2 (< 1.5cm migration).

Discussion: The two different techniques were examined on cadaveric specimens and it was noted that the obturator externus tendon was consistently cut as a part of the posterior soft tissue release. We conclude that this important structure should not be released as part of this approach to hip replacement. Obturator externus is an important adductor of the trochanter and preserving it decreases the incidence of trochanteric non-union.


AMH Jones AM New BJRF Bolland ROC Oreffo DG Dunlop

Introduction: Impaction bone grafting (IBG) for revision hip surgery can be a difficult surgical skill with a fine line between construct failure from insufficient compaction and intraoperative fracture from high impaction forces. Following on from our experience in the femur, in this study we used an acetabular model to test the hypothesis that the use of vibration for IBG could reduce the peak stresses thus reducing the intraoperative fracture risk and also improve the reliability and reproducibility of the impaction technique.

Methods: Revision hemi pelvis models were made (Pra-prosky Type 2a). A standard impaction technique was used for the control group, and the impactor tamps were coupled with a pneumatic hammer for the vibration group. The cavity was filled in 6 set steps with strain gauge readings taken throughout. The pelvis construct was then mechanically loaded. Graft compaction and micro motion post mechanical testing was assessed with micro CT.

Results: Vibration impaction led to a significant reduction (p=0.03) in the peak stresses during the impaction process. There was also significantly less variability in peak stresses for the vibration group compared to standard, both in sequential impactions by the same surgeon and between different surgeons. One medial wall fracture occurred in the control group only, similar to fractures encountered in the clinical situation. There was no significant difference in the degree of graft compaction or in the subsidence of the cup.

Discussion: We believe that this new technique of applying vibration to the IBG process can reduce the risk of intraoperative fracture whilst achieving good graft compaction and implant stability. This technique therefore has the potential to widen the ‘safety margins’ of IBG and reduce the learning curve allowing more widespread adoption of the technique for replacing lost bone stock.


E Yates A Goel JD Moorehead SJ Scott

Introduction: Posterior dislocation of replacement hips may occur during extreme hip flexion and adduction. Hip braces restrict movement, but they are uncomfortable and have a low patient compliance. Knee braces are more comfortable, and also restrict hip movement, by tightening the hamstrings. This study investigated the effect of a knee brace on hip movement.

Methods: A magnetic tracker was used to measure the movement of 20 normal hips in 20 volunteers, aged 25–62. Sensors were attached over the iliac spine and lateral thigh. Subjects were asked to lie on a couch and flex and adduct their hip three times with their knee bent and three times with their knee braced in extension. During each movement the tracker recorded hip flexion and adduction angles, with an accuracy of 0.15 degrees.

Results: With the knee flexed, the mean hip flexion angle was 66.00 (SD 11.0). With the knee braced, the mean hip flexion angle was 35.30 (SD 15.4). Hence the knee brace reduced hip flexion by 46 % (30.70) (paired t-test, P < < 0.001).

With the knee flexed, the mean hip adduction angle was 23.70 (SD 7.1). With the knee braced, the mean hip adduction angle was 21.60 (SD 5.6). Hence the knee brace reduced hip adduction by 9 % (2.10). This was not significant (paired t-test, P = 0.3).

Discussion: These results indicate that a knee brace can restrict hip flexion by almost 50%. This information may be useful for patients in whom restriction of hip flexion provides hip stability. As the knee brace is more comfortable than the hip brace, a better patient compliance is expected.


AWG Kinninmonth D McDonald E Lamont H Monaghan C Lawson J Brown R Siegmeth N Scott

Introduction: We report an evolving technique for managing peri-operative pain relief that has enabled early mobilisation and facilitated early discharge after primary Total Hip Arthroplasty (THA).

Methods: Our organisation has instituted a regime covering all aspects of the peri-operative care for THA. This includes: pre-operative counselling and preparation; multimodal anaesthesia and analgesia regime; intra-articular analgesia for 24 hours post-operation; early mobilisation regime. We carried out an audit of prospectively collected data of all patients undergoing primary THA in the six months from January to June 2008 (total of 138 patients), including pain scores, discharge from physiotherapy and follow up data at six weeks.

Results: A total of 122 THAs with complete data sets were included in the analysis. Of these 27% were mobilised on the day of surgery and 97% by post-operative day 1. Catheterisation rates were 16% and the need for post-operative intra-venous fluids was 15%. In-house physiotherapy discharged 58% of patients by day 3 and 87% by day 5. The visual analogue pain scores (on movement) on day zero and day one were within acceptable limits (medians were 2.5 and 2 respectively) and 84% of patients experienced no nausea or vomiting.

Functionally 14% of patients required out-patient physiotherapy assessment. At three months the median Oxford scores had improved from 43 pre-operatively to 20.

Discussion: This regime offers an efficient method for post-operative pain relief and early mobilisation with the added benefit of reducing post-operative catheterisation, intra-venous fluid requirements and the need for post-operative physiotherapy. It compares very favourably with published data on other peri-operative regimes using regional anaesthesia.


AMH. Jones TS Foong AM New BJRF Bolland DG Dunlop ROC Oreffo

Introduction: One of the main factors in the success of impaction bone grafting (IBG) in revision hip surgery is its ability to resist shear and to form a stable construct. Bone marrow contains multipotent skeletal stem cells and we propose that in combination with allograft will produce a living composite with biological and mechanical potential. In this study we looked at whether coating of the allograft with type 1 collagen followed by seeding with human bone marrow stromal cells (hBMSC) would enhance the grafts mechanical and biological properties.

Methods: A control group of plain allograft and three experimental groups where used to determine the effects that collagen and hBMSC have on IBG. The samples where impacted in standardised fashion previously validated to replicate femoral IBG, and cultured in vitro for 2 weeks. The samples then underwent mechanical shear testing and biochemical analysis for DNA content and Osteogenic activity.

Results: In isolation, both Collagen coating and seeding with hBMSC significantly enhanced the mechanical properties of the construct compared to the ‘gold standard’ of plain allograft. This was further enhanced (p=0.002) when the two processes are combined both with shear strength (245 vs. 299 kPa) and cohesion between the graft particles (46 vs. 144 kPa). The collagen coated group also showed increased osteogenic cell proliferation.

Discussion: This study has shown a role in the improvement of the mechanical properties of IBG coated with collagen and seeded with hBMSC. Collagen coating of IBG is a simple process and translation of the technique into the theatre setting feasible. The improvement in shear strength and cohesion could lead to earlier weight bearing for the patients and allow quicker recovery. The therapeutic implications of such composites auger well for orthopaedic applications. We are currently strengthening the above findings with an in vivo study.


A Kamali J Pamu A Hussain C Li JT Daniel L Counsell

Introduction: To develop a more physiologically relevant hip simulator test protocol and study the effect of microstructure on the wear performance of as-cast (AC) and double heat treated (DHT) devices under the new protocol.

Methods: Three pairs of AC and four pairs of DHT 50 mm CoCr metal-on-metal (MoM) devices were tested. The lubricant used was bovine serum. Stop-start motion was implemented between the two sets of kinetics and kinematics that alternated every 100 cycles throughout the test. Condition one: The flexion/extension was 30° and 15° respectively. The internal/external rotation was ±10°. The force was Paul type stance phase loading with a maximum load of 3 kN and a standard ISO swing phase load of 0.3 kN. Condition two: The flexion/extension was ±22°. The internal/external rotation was ±8°. The force was a maximum stance phase load of 2.2 kN and a swing phase load of 0.24 kN at 0.5 Hz frequency. Wear was assessed gravimetrically.

Result: The masking effect of 1 Hz speed and uninter-rupted motion, in providing exaggerated lubrication regime, was exposed under more physiologically relevant test conditions. The AC devices have significantly reduced wear when compared to the DHT devices. It can also be seen that from 0.5 to 2 Mc the divergence in wear has increased.

Conclusion: A more physiologically relevant hip simulator test protocol was successfully developed and implemented, in showing the effect of microstructure on wear as seen in vivo, where high wear of DHT devices has been observed. 295


A Hussain L Counsell A Kamali

Introduction: The purpose of this study was to determine the effects of edge loading on in vivo wear of hip resurfacings from retrievals.

Methods: The wear of retrieved BHR heads and cups was assessed using a Taylor-Hobson Talyrond 290 roundness machine. The maximum deviation of the profile from an ideal circle was taken as the maximum linear wear. Edge loaded devices (Figure 1a) were classified as cups which showed the maximum area of wear crossing over the edge of the cup. For all non-edge loaded pairs (Figure 1b), the wear area on the cup was within the sphere of the cup. In this study 50 pairs (diameter size 38 mm to 54 mm) were analysed.

Results: 28 pairs were classified as edge loaded, and 22 were not. Edge loaded pairs display greater linear wear than non-edge loaded components (Table 1). Edge loaded components showed no correlation between time in vivo and linear wear.

Discussion: Edge loaded pairs have a far greater range of linear wear which may be due to the variation of the angles of the components in vivo. Edge loading may be caused by an open cup, impingement and/or high combined anteversion angle of both the head and cup. The success of a hip resurfacing depends strongly upon articulation occurring within the sphere of the cup, which is reliant upon good component orientation.


ABY Ng KH Lee BC Se To

Introduction: Gentamicin is one of the most commonly used antibiotics in orthopaedic practice. It is mostly used as prophylaxis either through intravenous route, incorporated into bone cement or as local irrigation intra-operatively. The former two have been well studied. However, the literature on the therapeutic efficacy and safety of gentamicin irrigation is sparse. The objective of this study is to assess the safety of gentamicin irrigation in joint replacement surgery and associated infection rate.

Methods: This is a non-randomized, prospective study whereby patients undergoing joint replacement surgery were treated with gentamicin irrigation intra-operatively. Patients with pre-existing renal impairment were excluded. Two ampoules of Gentamicin (160mg) were irrigated into the wound before implants insertion and wound closure respectively. Cefuroxime was given pro-phylactically for all patients but none of them had intravenous gentamicin. Gentamicin level in the blood was assayed at 4 hours and 24 hours post-operation.

Results: A total of 138 patients were divided into two groups in this study. Group A (98 patients) consisted of patients with Total Joint Replacement and group B (40 patients) consisted of patients with hemi- arthroplasty of the hips and shoulders. There were 16 patients in group A (16%) and 12 patients in group B (30%) found to have plasma gentamicin level above 2mcg/ml. All but 6 of them had their gentamicin level dropped to below 2mcg/ml after 24 hours. The incidence of superficial wound infection was 6.1% (6 patients) in group A. No infection was reported for group B.

Discussion: Although none of them developed systemic complications, the plasma gentamicin level is high enough to raise an alarm. In this study, there was no apparent reduction in infection rate as compared to literatures reported. However, there was significant systemic blood gentamicin absorption.


J Daniel H Ziaee C Pradhan DJW McMinn

Introduction: In vitro simulation experiments and in vivo metal ion studies have been used to investigate metal-metal bearing wear. In vitro studies demonstrate an early high wear phase followed by a rapid decline to a significantly lower steady state phase. Clinical metal ion studies have never shown such a significant fall in later years although they reveal early high wear. This study compares in vitro and in vivo wear rates.

Methods: In vivo measurements were obtained from daily cobalt excretion in 26 patients with 50 and 54mm resurfacings up to 4 years. Their activity averaged 2Mcyc-per-yr. In vitro measurements were obtained from gravimetric wear rates (Prosim hip simulator) of ten 50 mm diameter resurfacings of the same design. Diluted calf serum was the lubricant.

Results: Simulator results, shown in fig 1, are wear per day equivalent. In fig 2 it is seen that during the first year simulator results predict wear that exceeds metal ion output. This can be accounted for by postulating that particulate debris is higher during the early years. Subsequently the plots converge showing that particulate debris release is progressively reduced in comparison to metal ion release. At 3 years the simulator predicts lower wear than that observed in the metal ion study. This can be accounted for by postulating that corrosion of previously shed particles is responsible for the difference.

Discussion: From these results it can be stated that during the run-in period, 4/5ths of bearing wear occurs as insoluble particles and the rest is soluble metal ions. This relationship progressively changes through the steady state phase. At around the 3-year stage, even if we assume that most bearing wear releases soluble metal ions, nearly a fifth (2.8/14.4) can only be accounted for through passive corrosion of wear particles.


S Konan FS Haddad

We describe our novel approach to managing infected periprosthetic fractures using a revision implant for temporary fracture stabilisation.

A series of 12 consecutive patients aged between 74 and 83 years (average age 81.51, SD 6.32) who were referred to the senior author with periprosthetic fracture and microbiologically proven infection, were managed by radical debridement and antibiotic therapy along with temporary implantion of a long stem cannulated, proximally hydroxyappatite coated and distally locked femoral prosthesis (Cannulock, Orthodesign, Christ-church, UK). Strut grafts, demineralised bone matrix and cable plating system where used in addition where indicated. Post operatively patients were allowed to mobilise as allows and antibiotics were continued until biochemical markers returned to normal.

A good clinical outcome and excellent functional outcome was noted in all 12 cases. No cases of immediate post operative complications such as DVT or PE were noted in any cases. In particular there were no instances of infections associated with prolonged immobilisation and hospital stay. Ten patients underwent a definitive revision hip replacement procedure within an average of 4.3 weeks (range 3.9 to 5.7, SD 2.15). Two patients required a second debridement and delayed definitive treatment due to persistently high inflammatory markers.

We believe that this novel approach significantly improves functional outcome in the management of infected periprosthetic fractures.


Alister J Hart Ashwath Bandi Paul Maggiore John A Skinner Richard Underwood Phillippa Cann

Data on retrieval analysis of current generation metal on metal hip replacements is scarce. Such analysis may help to reduce the incidence of failure and revision procedures. Our aim was to investigate the wear characteristics of explanted (ie failed) metal on metal (MOM) acetabular components in terms of; 1) wear rate; and 2) distribution of the wear (specifically edge loading).

30 hips were collected from 20 centres. The types of prostheses were: 15 BHR; 10 Cormet and 5 ASR. Wear of the acetabular components of the prostheses was measured using an out of roundness (Rondcom 60A) machine. We recorded the implantation and removal date of each hip.

The median linear wear rate was 7.32μm/year; this is at least 3 times greater than steady state wear rates reported for similar components worn in hip simulator studies. For 24 out of 30 cups, the greatest linear wear was recorded at the cup edge.

Failed metal-on-metal acetabular components were associated with higher than expected wear rates. The highest wear was seen closest to the cup edge in the majority of patients suggesting edge loading had occurred and probably explained the high wear rates. Accurate cup placement (to avoid edge loading) may reduce the failure of MOM hips.


H Ziaee J Daniel C Pradhan DJW McMinn

Introduction: Systemic metal ion elevation continues to cause concern with metal-on-metal (MM) bearings, particularly in young people, in view of their expected long life-time usage. Reducing bearing clearance is claimed to be a means of reducing metal ion release.

Methods: 26 consecutive male patients (mean age 55 years, mean BMI 26) who fulfilled the inclusion criteria and received a 50mm bearing (diametral clearance 100 μm) were included. Clinico-radiographic review and urine and blood specimens were obtained before and periodically after the procedure. Two hips were excluded during follow-up, (one revision and another contralateral hip arthroplasty). Results were compared with a similar design bearing, 50 or 54 mm diameter and conventional clearance.

Results: At the four-year stage all patients had excellent hip function. However three patients had progressive acetabular radiolucent lines. Cobalt and chromium in both cohorts at all follow-up levels were significantly higher than the preoperative levels. Compared to the conventional clearance (CC) group, the pre-operative urine chromium and 6M to 48M urine cobalt and chromium were significantly lower in the LC group (p < 0.005). Blood metal levels were lower in the LC group at 1-year follow-up but showed a converging trend thereafter. At 4-year follow-up, the differences are considerably less, with no significant difference in blood cobalt (figure).

Discussion: Under ideal conditions, closely matched components (lower clearance) would lead to a thicker fluid film and less wear. However a larger clearance than ideal is needed to allow for asphericities, surface roughness, deformation and the evolution of in vivo lubricant. Peri-acetabular radiolucent lines cause concern. Attempts to reduce systemic metal exposure should not adversely affect other bearing characteristics such as friction. The search for a bearing which would generate low wear without producing a detrimental effect on other bearing attributes, such as friction, should continue.


R Shariff S Panchani JD Moorehead SJ Scott

Introduction: Activities that require extreme hip movement can dislocate hip implants in the early post operative phase. The aim of this study was to assess the movement of the hip using four different techniques to retrieve an object from the floor.

Methods: An electromagnetic tracker was used to measure hip movement during these retrieval techniques:-

Flexing forward to pick up an object between the feet

Standing to the side of the object and bending

Squatting to pick up an object between the feet

Kneeling on one knee to pick up.

Measurements were taken from 50 hips in 25 normal subjects aged 21 to 61. Sensors were attached over the iliac crest and the mid-shaft of the lateral thigh. Data was collected as each technique was repeated 3 times. The tracker recorded hip flexion and rotation data at 10 hertz, with an accuracy of 0.15 degree.

Results: For each of the four techniques the respective mean (SD) movements were:-

Flexion: 75.8(28.6), 79.2(27.2), 87.5(29.7) and 30.4(17.3).

Extension: −0.2(2.5), 0.5(1.9), 0.1(2.3) and −0.4(3.3).

Internal rotation: 2.9(5.2), 1.4(3.4), 10.1(9.9) and 8.5(6.9).

External rotation: 12.6(10.3), 20.1(12.1), 11.9(6.5) and 7.3(7.1)

Kneeling had significantly less flexion and external rotation than all the other techniques (paired t-test, P< < 0.001).

Discussion: Flexion and external rotation were the most significant movements for each technique. The movements with the least and most flexion were kneeling (30.40) and squatting (87.50). The movement with the least and most external rotation were kneeling (7.30) and side pick up (20.10).

Kneeling has the least amount of movement, therefore, it minimises the risk of dislocation when retrieving an object from the floor.


H Ziaee J Daniel C Pradhan DJW McMinn

Introduction: Metal-on-metal (MM) bearing wear releases soluble metal ions which enter the systemic circulation and insoluble metal particles which collect in the periprosthetic tissues and disseminate through the lymphoreticular system. Disseminated particles also release ions through corrosion. The rate of metal ion level reduction following revision of a MM bearing offers insights into the relative contribution of metal ions from the bearing and from disseminated particles.

Methods: Whole blood concentrations and daily output of metal ions were studied, prospectively over a period of one year, in seven patients whose MM resurfacings were revised to metal–polythylene THRs. None of the patients had other metal devices or compromised renal function.

Results: Preoperative levels in these patients were highly elevated as expected from a failing device. Thereafter there is a trend of reducing metal levels in whole blood and urine in a biphasic manner. Over the first four weeks there is a rapid decline, followed by a period of slow decrease over the next twelve months (figure).

Discussion: The steep reduction of cobalt release immediately following revision supports the reported short half-life of cobalt ions. The later protracted trend can only be accounted for through progressive corrosion from previously worn particles. However this trend is also not sustained indefinitely and tends to approach control levels eventually.

Some authors have suggested that metal wear in patients with well-functioning MM bearings occurs only during the run-in wear phase and that continued corrosion of metal particles released during that period is responsible for metal level elevation later on. However the reducing trend in the later phase following revision in this study suggests that metal ion elevation from corrosion is not sustained indefinitely and therefore cannot by itself account for the persistent elevation of systemic metal levels throughout. Bearing wear continues to occur throughout bearing life.


N Demosthenous D MacDonald AH Simpson

Introduction: Limb lengthening with external fixators has been associated with many complications including pin tract infections, damage to neurovascular structures, joint stiffness, delayed consolidation, and pain. These can lead to a detrimental functional outcome and psychological upset with a consequent negative impact on patients’ quality of life. The Intramedullary Skeletal Kinetic Distractor (ISKD) is a fully implantable device that may offer a better functional and psychological outcome. The aim of this study therefore was to evaluate the functional and psychological outcome in a series of patients undergoing femoral lengthening with the ISKD.

Methods: Twenty patients underwent intramedullary lengthening via ISKD. Eighteen of these had lost femoral bone length secondary to trauma, and two were affected by congenital limb shortening (one had both femora lengthened at different time intervals). Patients completed Toronto Extremity Salvation Score (TESS) (to evaluate subjective physical disability), and Short Form 36 (SF36) questionnaires pre and post-operatively.

Results: Patients’ post operative TESS scores demonstrated a significant improvement in patient perception of their physical disability. SF36 responses after surgery improved in several areas including physical functioning, role limitation due to emotional problems, social functioning, mental health, pain experienced and change in health; the greatest improvements seen in role limitation due to emotional problem, social functioning, mental health, pain, and change in health.

Discussion: These results indicate that limb lengthening with the ISKD improves patients’ overall quality of life decreasing post operative pain, improving their social functioning and mental health, overall ISKD lengthening improves how the patients perceive their health and physical disability.


Puneet Monga R A Wilkes

Introduction: Limb lengthening using external fixation may be associated with problems such as pin-track infections, poor patient acceptance, muscle transfixation, secondary axial deformity and re-fractures. Intramedullary lengthening nails have been designed to address these issues.

Aim: To review the outcomes for femoral limb lengthening in adults managed by intramedullary lengthening nails.

Materials and Methods: A retrospective review was undertaken for 8 femoral lengthening procedures performed using intra-medullary lengthening nails over a three-year period. The average age of our patients was 34 years and the average duration of follow up was 26.5 months (Range 8 to 40 months). Either an Albizzia nail (5 femurs) or an ISKD (3 femurs) nail was used for the procedure.

Results: Target lengthening was achieved in 7 out of 8 femurs with a average of 38 mm (Range 19 to 70 mm) length gained. The distraction index (length gained per day) was 0.68 on an average and the consolidation index (length of bone consolidating per day) being 0.27 on an average. Premature consolidation in 4 cases, runaway acute lengthening in one patient, prominent metalwork in 4 patients and a bent nail were frequent obstacles and meant multiple visits to theatre.

Conclusions: The desired femoral lengthening is achievable using intra-medullary lengthening nails, thereby avoiding problems associated with callostasis using external fixation methods. It is however, important to counsel patients regarding possibilities of significant obstacles and multiple visits to theatre during the process.


PBM Thomas OW Ennis WW Wagner CI Moorcroft PJ Ogrodnik

Introduction: In a new external fixation system for tibial fractures, accurate reduction was achieved with a complex temporary device, the Staffordshire Orthopaedic Reduction Machine (STORM) following which the fracture was fixed using a simple titanium bar fixator (IOS). The fixator was designed to allow controlled bending to optimise movement at the fracture site for callus growth. Ideal mechanical properties are approached: elastic return is to the reduced position; epicentric placement minimises shear and distraction on weightbearing. Integral healing assessment measures bending stiffness. The device is single-use.

Methods: Closed or grade I compound unstable tibial shaft fractures in 38 patients were externally fixed using the STORM in the operating theatre to reduce the fracture prior to application of an IOS fixator. Immediate full weight-bearing was encouraged. Bending characteristics of the fixator allowed 1 mm of axial movement for 20 kg loading. Fixator removal time was determined by fracture stiffness measurements against which the integral IOS stiffness measurement was compared.

Results: Mean healing time was 18.1 weeks, shortest time 9.5 weeks. The healing endpoint was fixator removal at a bending stiffness of 15 Nm/deg in two orthogonal axes. There was no subsequent creep or re-fracture. Good reduction, defined as less than 3 deg of maximum angulation and less than 3 mm of maximum translation, was achieved and maintained.

Discussion: The IOS/STORM system allows safe and effective treatment of tibial shaft fractures. With the fracture reduced, the external fixator screws can be placed in optimum positions. Good reductions were achieved and maintained. The IOS bending characteristics appear to approach the optimum for callus growth. The simple integral fracture stiffness measurement method has been validated against more complex devices.


MA Rashid M Vincent MG Dennison SL Royston

One of the most challenging cases encountered by orthopaedic surgeons is chronic osteomyelitis. The mainstays of successful treatment include: radical debridement, stabilisation of the bone if necessary; control of infection and finally skin cover or closure.

Negative pressure dressings have been used for over 10 years in the treatment of acute and chronic wounds with recognised benefits. Topical negative pressure wound therapy with instillation of solution in the local area (VAC Instill Therapy System®) is a new device available in the armamentarium of a limb reconstruction surgeon. This device automatically delivers instillation fluid into the infected wound, where this fluid is held for a while before application of topical negative pressure. This cycle helps remove infectious material leading to clean closed moist environment for better wound healing.

Senior authors (MGD and SLR) have used this VAC Instill therapy in 10 cases of chronic osteomyelitis from April 2007 to November 2008. All patients have been included in this study. All patients had (thorough) bony and soft tissue debridement followed by application of VAC Instill therapy with local delivery of antibiotics.

All patients were male with mean age of 39 years (range 20–56 years). There were eight cases of tibial osteomyelitis, one distal radial and one calcaneal osteomyelitis. Most had mixed growth, with Staphylococcus being most common infecting organism. Average duration for VAC Instill therapy was 32 days (range 20–71 days). Average hospital stay was 33 days (range 15–85 days) and average time to wound closure was 39 days (range 19–90). There were two failures of treatment one later had Lautenbach procedure and other had below knee amputation.

We conclude that VAC Instill therapy is very successful in the management of chronic osteomyelitis. These are the only early results available in the literature. Further studies are needed to back these findings.


B Davis S Nayagam

Sub-muscular plating is an established technique in the management of long-bone fractures and reconstruction. In the femur, the presence of the vascular structures medially favours the lateral approach and as such, the technique of medial femoral sub-muscular plating has not, to the authors knowledge, been previously described.

We report a series of 5 patients employing the medial approach to femoral sub-muscular plating. The indications and limitations of the technique are discussed with particular reference to reducing external fixation times, avoidance of stress risers and areas of previously traumatised or infected tissues. The surgical technique for medial femoral sub-muscular plating with emphasis on the role of vastus medialis in the protection of the vascular structures, together with cross sectional anatomy is described.

Medial femoral sub-muscular plating is a useful technique in specific indications and can be performed safely with an understanding of the relevant anatomy.


Full Access
JV Banks S Panchanni B Davies JC Widnall N Giotakis B Narayan S Nayagam

Introduction: The treatment of femoral nonunions remains challenging despite modern surgical techniques and adjuncts to fracture healing. We present a series of 14 patients in whom a bifocal treatment technique has been used in order to achieve bony union and correct limb length.

Methods: Patients were identified from theatre records and their hospital notes and x-rays were retrospectively reviewed. All patients underwent bifocal treatment for femoral nonunions – debridement and internal fixation (single or double plating) of the nonunion and lengthening at the opposite end of the bone to correct limb length discrepancy. Initially the procedures were staged, with treatment of the non-union then subsequent lengthening. However, our technique has evolved to perform all procedures in a single stage. All lengthening procedures were done with a monolateral (Orthofix LRS) fixator.

Results: 11 patients had distal and 3 proximal femoral nonunions. 13 patients were male and 1 female. The non-union united with the index procedure in 13 patients, 1 is still undergoing treatment. Limb length discrepancy range 2–5 cm was fully corrected in all patients with no axial deviation of the regenerate. There were no pin site problems.

Discussion: Femoral nonunions are challenging due to multiple previous procedures, insecure grip on the smaller fragment and bone loss. Successful union can be achieved by ORIF with bone grafting, but this does not restore length. Treatment by the Ilizarov method alone is associated with significant morbidity, particularly knee stiffness. A bifocal strategy provides stable internal fixation of the non-union to allow bone healing, and any consequent loss of length is safely restored. We believe this to be a safe and effective technique to treat femoral nonunions.


R Sharma N Shaikh A Khaleel

Introduction: The use of Ilizarov frames is contraindicated in patients with psychiatric conditions, thought to be due to non compliance. We present our experience of treating five fractures with Ilizarov frame in four patients who sustained their injuries through parasuicide.

Method: Consecutive series of patients treated by a single surgeon at our institution. Five fractures in four patients, (one bilateral fracture) were treated with an Ilizarov fine wire frame. All fractures were comminuted distal tibia (pilon): one was B3.3, two C3.2 and a further two C3.3 using the AO system. Four out of five fractures were open Grade IIIA. Outcome was based on functional score (Olerud and Molander); SF 12 and radiological assessment.

Results: There were three females and the mean age was thirty-one years. Of the five fractures, three united successfully, at eight months; one achieved a malunion and one an aseptic non-union at 1 year

Discussion: Our experience suggests complex fractures can be treated favourably with circular frames in parasuicide patients. The patients were generally compliant with frame care and the outpatient monitoring was no different from any other patient with similar injuries.


PBM Thomas OW Ennis WW Wagner CI Moorcroft PJ Ogrodnik

Introduction: The Staffordshire Orthopaedic Reduction Machine (STORM) was developed to assist in the reduction of tibial shaft fractures prior to the application of an external fixator. Its use has now been extended to fractures of the tibial plateau and plafond, where it has been utilised to gain and hold a good reduction prior to the application of various internal and external fixation techniques.

Methods: The STORM was used sterile within the operative field on a standard radiolucent operating table. It was applied with two tensioned 2 mm wires: the distal through the calcaneum; the proximal through the proximal tibia for shaft and pilon fractures, and through the distal femur for plateau fractures.

Controlled traction was applied through these two wires. Torsion was independently corrected and locked. Translation and angulation was corrected using two translation arms each applied to the tibia with a single unicortical screw. The STORM was removed at the end of each operation.

Results: The STORM was used in 241 cases.

Pilon (n=42): bridging hinge 23 (t [mean operation time in minutes]=102.9), percutaneous plate 10 (t=131.4), ring fixator 5 (t=140), screws and fibula plate 3 (t=77), other 2.

Plateau (n=23): ring fixator 11 (t=129.7), LISS plate 8 (t=98.6 mins), monolateral Garches fixator 3 (t=64.4), screws only 1 (t=15).

Shaft (n=176): monolateral fixator 138 (t=69.1), ring fixator 37 (t=131.2), nail 1 (t=65).

Ilizarov rings up to 200 mm were accommodated.

Discussion: The STORM is a safe device for reliable reduction of tibial plateau, shaft and pilon fractures which allows good access for internal or external fixation. No significant complications attributable to the use of the current design of the STORM were encountered.


S Panchani J Banks B Davis S Nayagam N Giotakis B Narayan

Introduction: The subtrochanteric area of the femur is subject to large tensile and compressive forces. The rate of nonunion following operative fixation of such fractures is about 7–20%. Revision surgery to obtain union is difficult because of the small size of the proximal fragment, muscle forces acting in 2 planes, and bone loss.

We present the results of a series of 9 consecutive patients with subtrochanteric non-unions treated by double plates.

Methods: Retrospective analysis of 9 consecutive subtrochanteric nonunions treated with double plates and additional osteoinduction (bone graft, or BG+BMP-7).

Results: There were 5 male and 4 female patients, with ages from 50–82 years (mean 65). All were treated in a single-stage procedure by implant removal, a lateral plate and a separate anterior plate. One patient had had a previous unsuccessful revision procedure with an intra-medullary device.

One patient with liver cirrhosis died 5 days postoperatively. Two patients are currently 8 weeks post surgery. All the others healed in a mean of 5.1 months (range 4–6 months).

Two patients underwent distal femoral lengthening to compensate for bone loss.

Discussion: The high muscle forces around the proximal femur require a sound mechanical environment for bone healing to occur. This is particularly marked in nonunions. The small size of the proximal fragment can result in suboptimal fixation. The addition of the anterior plate provides better fixation and also neutralizes the sagittal forces.

We believe that double plating neutralizes all the forces around the proximal femur, providing the best mechanical environment. Given the limits of the small numbers and the retrospective nature of the study, we believe that this method of treatment offers a sound surgical strategy, reflected by our success rate.


M Ramappa N Rajesh R J Montgomery

Introduction: Infected non-union in the forearm is a rare and challenging situation. It can result in persistent deformity, shortening, bone loss, joint stiffness and disability. Secondary procedures are often required for correction of bone defects and deformity. Bone transport may be the only realistic method of treatment.

Case presentation: 56-year-old gentleman referred with an infected non-union of left distal radius. He underwent bone debridement with ilizarov frame application for distraction osteogenesis. After a period of one month, a longitudinal transport wire was inserted through the distal segment to the proximal segment and distraction was carried using this wire. This was supplemented by iliac crest bone graft and OP-1 substitute at docking stage. The frame was removed at 18 months, following which he sustained a refracture. ORIF with bone graft was performed. Finally a good consolidation was achieved. There was about 50% loss in pronation and supination and about 15 degrees short of full extension at the final followup.

Another 57-year-old gentleman referred for an infected non-union of the ulna with a severe bone defect. He was treated with a TSF application and corticotomy for distraction osteosynthesis. There has been a satisfactory progress in the bone transport and recently underwent a docking procedure with bone graft insertion.

Discussion: Post traumatic infected non-union with segmental bone defect in the forearm can be successfully managed with bone transport. Unlike tibia, where this procedure is commonly done, forearm bones have a complex soft tissue envelope which can rule out the use of external transport, especially in the radius. We found the longitudinal wire technique useful for transport of radius. Internal fixation can be used to salvage initial failures, provided that infection and substantial bone defects have been eliminated. This treatment is intensive and difficult for patient and surgeon.


DM Taylor Y McManus N Day HK Sharma

Introduction: Obtaining adequate images can be difficult in ring fixator patients during outpatient follow-up. Following a recent publication, we introduced the spirit level technique as an effective method to ensure better quality images for interpretation, reduce unnecessary x-ray exposure, and improve clinic efficiency.

Method: A comparison was made of radiograph quality, patient inconvenience and x-ray exposure between standard X-ray techniques and those with a frame mounted spirit-level in all patients attending the senior author’s outpatient clinic for routine follow up following Ilizarov and Taylor-Spatial frames.

Prospective data was collected using a paper proforma in frame clinic. Information was gathered on all patients sent for plain radiographs. Radiographers collected data regarding time taken in the X-ray Department and total number of radiographs taken to gain the images required. The senior author recorded if these images were satisfactory and if returned to the department for further imaging. The radiation dose was retrieved from the Radiology computer.

The control group consisted of patients from clinics prior to implementation of the spirit-level device. Following a period of familiarization, data was collected from the study group using the spirit-level.

Results: (Table deleted)

Conclusion: The implementation of a simple frame mounted spirit-level as a guide for the radiographers in the outpatient clinic improves x ray quality, to assess healing, and significantly reduces the number of suboptimal images. The data does not support a significant impact on patient inconvenience.


WGP Eardley DM Taylor PJ Parker

Introduction: Complex extremity injury remains a challenge to those involved in both its emergent and definitive care. Anecdotal concerns exist regarding exposure of orthopaedic trainees to such cases in the light of recent changes in surgical training. We aim to establish the perceived confidence, exposure to caseload and adequacy of training of United Kingdom (UK) Orthopaedic Specialist Trainees in the management of significant extremity trauma.

Method: A web-based survey was sent to a sample of orthopaedic trainees. 222 responses from 888 trainees were required to achieve a 5% error rate with 90% confidence. 232 responses were received.

Results: Perceived confidence and adequacy of training in wound debridement and fasciotomy is high despite infrequent exposure and training is perceived as adequate. With regards to assessment of limb viability and amputation for extremity injury, exposure is minimal, perceived confidence is lower, particularly in the case of amputation and for this scenario over a third of trainees report their training as inadequate. Perceived confidence in dealing with hand trauma is low and is associated with sparse exposure to cases resulting in a quarter of trainees reporting their training as inadequate. For all scenarios, confidence is seen to increase with time spent in training with the notable exception of post-CCT trainees whom report a lower confidence to their colleagues in the latter years of training.

Discussion: Despite infrequent exposure, it has been demonstrated that perceived confidence and adequacy of training in many aspects of extremity injury is high. Concerns are apparent with the management of hand trauma and amputation surgery. This study is the first of its kind to offer a valuable insight into the current training perceptions and requirements of junior orthopaedic surgeons at a national level.


YHK Lodhi KR Durve PR Padala M El-Shazly O Schindler

Introduction: We present preliminary short term results of medial opening wedge high tibial osteotomy with hemicallotasis using a monolateral external fixator, combined with microfracturing, in younger active patients with established Grade IV medial compartment osteoarthritis.

Methods: Prospectively collected data was analysed for 28 consecutive knees in 27 patients undergoing this procedure. Mean age was 47 years (range 28 to 64); follow up was 23 months (range 7 to 61).

Results: Mean Lysholm scores improved from 63.6 before surgery (range 42 to 85) to 81.6 at latest follow-up (range 46.5–100) (p< 0.001). Similarly, the mean Tegner activity scale improved from 1.7 (range 1–4) to 3.3 (range 1–6) (p< 0.001). Average IKDC score at last follow-up was 68 (range 35.6–100). Mean pain score (visual analogue scale 0 to 10) improved from 5.5 pre-operatively (range 1–9), to 3.5 at latest follow-up (range 0–8) (p< 0.001). All but 4 patients reported improved pain scores, one of whom had patellofemoral pain. Superficial pin site infection occurred in 6 patients (21.4%) and settled with oral antibiotics in all cases.

Discussion: The use of hemicallotasis for high tibial osteotomy in association with extensive microfracturing of medial compartment provides a viable, minimally invasive method for management of the young active patient with medial compartment osteoarthritis, without the risk of serious complications. In the short term even with advanced full thickness damage, this provides effective pain relief, helps put off more major arthroplasty alternatives and allows patients an improved activity level. The external fixator provides a very stable functional stabilization, superior to other available methods of internal fixation.


PM Robinson MC Papanna BV Somanchi SA Khan

Introduction: The treatment of isolated medial compartment osteoarthritis (OA) in the young or physically active patient is a challenging problem for the orthopaedic surgeon.

The rationale for high tibial osteotomy (HTO) in medial compartment OA with varus deformity is to correct varus malalignment and to redistribute load to the non-diseased lateral compartment of the knee. Here we present our early to mid-term clinical and radiological findings.

Methods: Between October 2005 and April 2007 9 patients underwent HTO and TSF application. Pre-operative OA grade was recorded using the Ahlbäck classification. Radiographs were used to calculate the pre and post operative measurements for the tibiofemoral angle, the mechanical axis deviation and the tibial slope. Correction planning was carried out using the Spatialframe software package. All operations were performed by a single experienced consultant orthopaedic surgeon specialising in Ilizarov and limb reconstruction surgery. Pre and post-operative Oxford knee scores were collected for each patient.

Results: Median follow-up was 19 months (range 15–35). Median age at operation was 49 years (range 37–59). On preoperative radiographic examination eight knees were Ahlbäck grade 1 and one knee was Ahlbäck grade 2. The median time spent in the frame was 18 weeks (range 12–37). The median total angle of correction according to correction program given was 14 degrees (range 10–22) and the median duration of correction was 18 days (range 14–36) with 6 patients requiring an additional correction program.

2 patients subsequently underwent matrix induced autologous chondrocyte implant (MACI) for osteochondral defects.

In the primary OA group we found an improvement in mean Oxford knee score after HTO from 28.3 to 37.8/48 post-operatively. 1 patient was non-compliant with the correction and required a total knee replacement (TKR) for continued pain at 36 weeks post frame removal. 1 patient required fibular osteotomy during their correction.

6 (67%) of the 9 patients had a documented pin site infection. The median Otterburn grade was 3 (range 0–4). There were no cases of chronic bone infection.

Conclusions: High tibial osteotomy performed with the Taylor spatial frame presents a viable treatment option in active patients with early medial compartment OA. With TKR as an end point the survival rate of HTO for treatment of OA was 88.9% at a median of 19 months follow-up. Our results also indicate successful use of the technique in combination with MACI.


PM Robinson MC Papanna SA Khan

Introduction: The Taylor spatial frame (TSF) (Smith & Nephew) is a hexapod ring fixator that utilises the Ilizarov principles. The TSFs design is based on the Stewart-Gough platform, the use of which was originally described in mechanical engineering. Due to its unique design the TSF is extremely versatile in limb reconstruction surgery, allowing six degrees of freedom bone fragment manipulation with a high degree of precision that is aided by correction planning software.

Methods: Between October 2003 and December 2008 66 consecutive patients were treated using the TSF by a single consultant surgeon. Median patient age was 45 (range 20–69). The original pathology included 18 mal-unions, 13 acute fractures, 10 medial compartment osteoarthritis (OA) of the knee with varus deformity, 8 infected nonunions, 7 limb length discrepancies, 5 nonunions, 3 ankle OA, 3 post traumatic posterolateral corner of the knee instability, 1 multiple epiphyseal dysplasia, 1 lateral compartment OA of the knee with valgus deformity, 1 deformity secondary to Polio. There were 10 ankles, 19 knees (1 femur, 18 tibiae) and 37 tibiae.

Results: The procedures performed were 16 high tibial osteotomies, 2 frame assisted platings, 8 bone transports, 32 deformity corrections, 14 Ankle arthrodesis (9 primary, 5 revision after nonunion), 9 limb lengthening and 1 derotation. The median bone transport distance and lengthening achieved is reported.

The median time spent in the frame was 21 weeks (range 9–81), including 8 patients who required 2 frames to complete their treatment.

54 cases had a satisfactory outcome in terms of union and deformity correction using only the TSF, 5 cases were ongoing. Complications included 1 below knee amputation, 2 docking site nonunions requiring ORIF, 2 nonunions after ankle arthrodesis requiring T2 nails. 2 frames were removed due to compliance issues. 2 patients developed deformity requiring Tendo-achilles lengthening. There were 2 DVTs and 2 non-fatal PEs. 1 patient suffered a fracture at a femoral pin-site after TSF removal which was treated with external fixation. The median Otterburn grade of pin-site infection was 2 (range 0–4).

Conclusion: The Taylor spatial frame was used successfully in several different pathologies ranging from acute trauma to chronic deformity. The TSF provides the surgeon with a reliable treatment strategy that is both versatile and accurate.


P O’Toole M Noonan S Byrne P Kiely J Noel E Fogarty D Moore

Introduction: Percutaneous epiphysiodesis is a well established procedure in the treatment of leg length discrepancy. Many techniques have been described ranging from an open technique to the more recently described percutaneous technique. This study assesses the percutaneous single portal technique, in combined distal femoral and proximal tibial lower limb epiphysiodesis, performed by a single surgeon.

Methods: We performed a retrospective review of cases performed in a single institution by a single surgeon from 1994 to present. A total of 45 combined epiphysiodesis were performed. 40 patients qualified for the study group with at least 2 years follow up. There were 19 female and 21 male patients, with the operative side equally shared between left and right.

Results: The mean predicted leg length discrepancy using the Mosley Straight Line Graph was 2.43 cm. The mean final leg length discrepancy, at an average follow up of 31 months, was 1.5 cm with a range of 0 to 2.81 cm. There were no angular deformities at follow up. One female patient had a knee effusion which resolved spontaneously. One male patient complained of anterior knee pain initially post surgery however this resolved at final follow up without treatment. The majority of patients (n=34) were inpatients, however more recently this procedure has been successfully carried out as a day case (n=6).

Discussion: Percutaneous epiphysiodesis has been accepted as a standard technique to treat leg length discrepancy of 2 cm to 5 cm. Several techniques have been described in the literature with varying complication rates. This study shows that single portal combined epiphysiodesis is successful and has a relatively low complication rate.


S Atherton R Davies A Lee S Nayagam

Introduction: Lengthening for congenital femoral hypoplasia is associated with a significant refracture rate and problems in recovery of knee motion. We present a series of 7 patients where two techniques of lengthening were used and recovery of knee motion compared.

Methods: This is a retrospective study. The outcome of interest was recovery of knee motion. All children were diagnosed to have congenital femoral hypoplasia. In two patients (group A), conventional metaphyseal osteotomies of the femur and tibia, with ankle and knee bridging fixators were applied. In the remaining five (group B), a combination of soft tissue releases, patella ‘capture’, a modified external fixator configuration and early conversion to internal fixation was used. Osteotomies of tibia and femur were performed in the mid-shaft and lengthening progressed at 0.75 mm per day. At 4 months, before regenerate consolidation, both femur and tibia were plated using a submuscular technique. The limb was supported in a cast, which was replaced by a brace at 3 weeks and knee motion exercises started. Lengthening was kept to within 15% in both groups.

Results: Recovery in knee flexion to greater than 90 degrees was accomplished by 4 of the 5 Group B patients by 4 months. One patient failed to attend for physiotherapy and did not progress with knee motion recovery. One patient sustained a fracture proximal to the submuscular plate which needed revision surgery. This did not hinder progress with knee motion recovery. In comparison, patients in group A reached 90 degrees of flexion at 12 months with one patient not exceeding 85 degrees at final follow up and subsequently needing a quadricepsplasty.

Conclusion: Recovery of knee motion may be assisted by soft tissue releases in combination with early conversion to internal fixation.


P O’Toole M Noonan A North J Stratton P Kiely J Noel E Fogarty D Moore

Introduction: Bone transport, or distraction osteogenesis, is a recognised technique to reconstruct extensive bony defects resulting from excision of bony tumours. Ilizarov demonstrated bone formation under tension allowing the movement of a free segment of living bone to fill intercalary defects. This study assesses the use of bone transport in the management of patients with resectable long bone tumours.

Methods: We retrospectively reviewed patients who underwent bone transport in two institutions, performed by a single surgeon. A total of 14 patients were included in the study. There were 11 males and 3 females. Histological results demonstrated osteosarcoma (n=7), Ewing’s sarcoma (n=6), and parosteal chondrosarcoma (n=1). The site of the tumour was the femur and tibia in 8 and 6 cases respectively.

Results: Bone transport was fully completed in 9 patients. Of the 5 patients remaining, 3 are currently in cast, 1 is currently undergoing tibial lengthening, and 1 patient died from local recurrence and distant spread of disease. The average length of bone resected in the tibia was 11 cm (range 8–15 cm), while in the femur the average was higher at 16.5 cm (range 12–27 cm). All patients underwent autologous bone grafting of their docking site from either the anterior or posterior iliac crest on the ipsilateral side. The average time in frame was 24.8 months. One patient undergoing tibial bone transport fell and sustained an ipsilateral supracondylar femoral fracture which was successfully treated with an external ring fixator.

Discussion: Bone transport is a recognised method of reconstructing extensive bony defects and is beneficial for patients with a good prognosis. It is a specialised technique and requires a multidisciplinary approach. Other techniques can be less time consuming however distraction osteogenesis avoids the complications associated with prosthetic or allograft replacements.


R Nanda M Ramappa R J Montgomery

Introduction: Arthrodesis of the knee nowadays is used as a salvage procedure, commonly for patients with a failed TKR or in infected trauma cases. We present 4 patients with extensive bone defects following septic sequelae of trauma treated by Arthrodesis of the knee joint.

Materials and Methods: Four patients (avg. 46.5 years; range 37–57 years; three male and one female) with longstanding infected non-union fractures (3 months–2 years) at the knee joint (three Tibial plateau and one distal femur) were treated by initial debridement and removal of dead or infected bone. This led to substantial bone defects (6–12 cm) of the debrided bone at the knee joint. The patients then underwent bone transport with a circular frame to compensate for this bone defect before achieving an Arthrodesis of the knee joint. Three patients also had a free muscle flap for soft tissue coverage before bone transport was begun.

Results: Arthrodesis of the knee was achieved in all patients at an average time of 26 months (20–32 months). None of the patients have any active infection of the limb.

Discussion and Conclusions: Knutson et al (1984) said that massive bone loss may substantially reduce the success rate of Arthrodesis of the knee. Wilde and Stearns (1989) noted decreased fusion rates with greater degrees of bone loss. In our series the bone defects were a sequelae of infective non–union, this further complicates the healing process. However, using circular frame for Bone transport to overcome the defect and to achieve compression at the Arthrodesis site is a useful technique for such challenging cases.


A.D. Gorva T. Mathews SS Madan S Giles S. Jones J.A. Fernandes

Introduction: Plastic deformation of the regenerate bone is a complication noted soon after limb lengthening. However, less is known about the factors responsible for the development of plastic deformation.

Materials and Methods: Retrospective analysis of 35 X-rays of achondroplast children who had limb lengthening were reviewed. The study compared Monofocal Vs Bifocal and Long lengthenings(> 10 cms) Vs modest lengthenings(≤ 10 cms) of tibial lengthening. Other parameters included in study were Bone healing Index, total length gained and sagittal and coronal axial deformities. There were 20 females and 15 males, 21 long lengthenings and 14 modest lengthenings in the study. The joint orientation and diaphyseal angles(antero-posterior and lateral X-ray views) was used for the measurement of plastic deformation of the regenerate bone.

Results: The mean age at operation was 10 years (range; 6–16 years). There were 29 cases of monolateral fixator and 6 of Ilizarov ring fixator, Of which 26 had monofocal lengthening and 9 had bifocal lengthening (34 callotasis and 1 chondrodiastasis). The total average length gained was 10 cms (range; 23–152). The mean bone healing index and external fixation index/time were 41 days and 352 days respectively. Plastic deformation of the regenerate bone was seen in 26 cases in total. 24 out of 29 cases of monolateral fixator (82%) developed plastic deformation. 44%(4/9) of bifocal group and 84%(22/26) of monofocal group showed evidence of plastic deformation. The long lengthenings showed plastic deformation in 85% (18/21) of the cases, whereas only 57%(8/14) of the cases were positive in modest lengthening group. Most of the axial deviation was in the coronal plane in 92% (24/26) and the sagittal plane accounted to only 23%(6/26) requiring surgical correction.

Conclusions: Long lengthenings and monofocal techniques showed more plastic deformation than bifocal and short lengthenings. However, Ilizarov ring fixator with bifocal corticotomy seemed to be promising with less association with the above entity in our recent experience.


ML van der Linden PJ Rowe RW Nutton

The primary aim of this study was to investigate whether objective daily physical activity, measured using an activity monitor one year after Total Knee Arthroplasty was different from that measured before surgery.

An activity monitor (activPAL) which records the number of steps in addition to the time spent sitting or lying, standing and ‘stepping’ was used to quantify physical activity. Forty-five patients with osteoarthritis (average 69.8 years old) were assessed an average of 38 days before and 368 days after total knee arthroplasty-before. A group of 40 age matched controls were also recruited. In addition to objective daily physical activity, knee range of motion, pain using the visual analogue score and the Western Ontario McMaster University Osteoarthritis Index (WOMAC 3.1) were also recorded before and after surgery.

Patients reported a significant decrease in pain (54%, p< 0.001) and increase in function (62% p< 0.001) after surgery. However, measures of physical activity showed much smaller improvements which were mostly statistically non-significant. The number of steps taken on one day increased by 19% (from 6438 to 7634 steps, p=0.119) and time spent stepping increased from 7.9% to 8.7% (p=0.27). Only average cadence and estimated energy expenditure were statistically significantly higher after surgery, 8% improvement, p=0.003 and 8% improvement, p=0.026 respectively. Stepwise regression analysis showed that only 11.4% of the improvement in physical activity was due to the decrease in pain.

One year after TKA levels of physical activity were still significantly (p< 0.05) lower than those of a group of age matched controls. In conclusion, other factors not measured in this study are to a large part determining the amount of physical activity in patients after knee surgery. Future studies aiming to identify those factors are warranted.


S Al-Naser ETR James A P Davies

Aims: To establish whether pre-existing anxiety and depression negatively impacts symptomatic and functional outcome of knee arthroplasty.

Methodology: A prospective study. Ethical approval was obtained prior to the study. Psychological status was assessed using the Hospital Anxiety and Depression Scale; a validated self-assessment tool for detecting anxiety and depression. The Oxford and the American Knee society scores were used to assess the knee status. All scores were documented pre-operatively and at six weeks post-operatively. Results were submitted for independent statistical analysis.

Results: 105 consecutive primary knee replacements were included in the study. 39% (41 patients) had abnormal pre-operative anxiety states. This percentage dropped to 28.2% (29 patients) post-operatively (P=0.034). 25.7% (27 patients) had abnormal pre-operative depression states which improved to 15.5% (16 patients) post-operatively (P=0.011). There were high degrees of correlation between abnormal anxiety and depression states both pre-operatively (P< 0.001) and post-operatively (P< 0.001). Patients with abnormal anxiety pre-operatively had worse knee scores both pre-operatively (P=0.17) and post-operatively (P=0.009) than those who did not. Patients with abnormal depression pre-operatively had worse pre-operative Oxford scores (P=0.036), and worse Oxford (p=0.006) and AKSS knee scores post-operatively (0.043).

Conclusions: Abnormal anxiety and depression states are common in patients with knee arthritis presenting for knee arthroplasty. These conditions can improve post-operatively. Patients with abnormal pre-operative anxiety and depression do less well following knee arthroplasty than those who do not. Pre-operative psychological assessment is easy to perform and does act as a predictor of early outcome. Further research is needed to assess whether treating these psychological conditions prior to knee arthroplasty improves the outcome or not.


S Hakkalamani P Mereddy M Nixon R Finley N J Donnachie

A consecutive group of 150 patients undergoing primary TKA performed by a single surgeon using single prosthesis were studied prospectively. The purpose of this study was to compare the clinical and radiographic results of TKA in obese and non-obese patients.

The patients were categorized into two groups: non-obese (body mass index (BMI < 30 kg/m2) and obese (BMI > 30 to 40 kg/m2). The Primary outcome measures: SF-12 and WOMAC scores were used as generic outcome measures, and the Knee Society scores were used to assess clinical outcome of TKA. The scores were done pre-operatively and at 1, 3 and 5 years post-operatively. Secondary outcome measures included patellar position, anterior knee pain, infections, revision rates, deep-vein thrombosis and pulmonary embolism, length of hospital stay and mortality.

Seventeen patients have died since and none were lost to follow-up. Obese patients had less benefit and overall KSS outcome scores at one year (p-value 0.05) but had similar scores at 3 and 5 years (p-values 0.3 and 0.5). Pre-operative WOMAC and SF-12 scores were significantly worst in obese patients (p-value 0.009 and 0.005) but had the similar outcome at 1, 3 and 5 years. Three patients in the series required revision surgery for infection. One patient had DVT and another had PE post-operatively.

Overall obese patients although had lower KSS scores at one year but had better outcome in SF-12 and WOMAC scores at one year. There was no difference at 3 and 5 years. We found that body weight did not influence adversely the outcome of TKA at medium term.


ML van der Linden PJ Rowe RW Nutton

The aim of this study was to investigate the effects of implant design and gender on the outcome of Total Knee Arthroplasty (TKA) in patients with osteoarthritis (OA).

In this double blind randomised controlled trial, patients with OA received either a standard posterior stabilised implant (n=28) or high flex version of this implant (n=28). Walking speed, knee flexion under anaesthesia (‘drop test’), knee flexion in sitting and during functional activities as measured by electrogoniometry, daily number of steps, Quality of Life (SF36), the function component of the Knee Society Score, pain (Visual Analogue Score) and extensor strength were measured before and one year after TKA.

Type of implant did not have a significant effect on any of the outcome measures recorded, while gender showed significant effects both before and after surgery. Before surgery, females had a significantly lower knee range of motion, (both passive and functional), lower Knee Score function component, walking speed and strength. After surgery they had a statistically significant lower range of knee motion during functional activities such as walking up and down a slope. Strength was also still significantly lower but post-operative self-reported function were similar for both genders. There was also no difference between male and female participants regarding Quality of life, objective daily physical activity or pain.

The results of this study showed that there is a clinically and statistically significant difference between the function of female and male patients both before and after total knee arthroplasty. Although female patients seem to benefit more from TKA than males, on average they do not achieve the same functional knee motion after surgery. Unlike gender, implant design did not influence the knee motion or function in this group of patients. This has important implications for future research and treatment planning in order to maximise the functional outcome after TKA.


Junjie Wu Aditi Augustine David Deehan Jim Holland Emma Reay

The Kinemax Plus knee replacement has a reported 10 year survival of around 96%. However we found the survival rate of this implant in our cohort to be 75% at 9 years. No abnormalities were found for clinical and radiological parameters. At reoperation the most striking feature was that of significant ultra-high molecular weight polyethylene (UHMWPE) failure. Oxidative and structural analysis of the polyethylene components was therefore undertaken.

Ten Kinemax Plus tibial inserts were analysed; one was a shelf-aged unused implant, the others were explants. An FTIR analysis of the data showed that oxidation is present in all samples. The degree of oxidation however varied with depth and location. Except for a sharp oxidative peak approximately half way into the sample, the shelf aged samples had a fairly constant level of oxidation. The retrieved implants had an overall higher level of oxidation in both bearing and non-bearing regions. The latter had less of a variation in oxidation which implies that in vivo loading exaggerates the degree of oxidation. In the non-articulating regions oxidation of the explants was found to peak often at the region of about 40% from the bottom surface in all retrieved samples. By contrast, most articulating region had two oxidative peaks; one occurring at approximately 1–1.5mm from the surface, which is consistent with findings on subsurface oxidation, and another occurring about 2–3mm from the bottom surface.

SEM imaging provided evidence for the presence of fusion defects by indicating grain boundaries through-out the explants. This indicates a compromised material which is more susceptible to damage. Fatigue loading of the implant has also been seen to produce a subsurface stress maximum at approximately 1 to 2mm below the articulating surface. It is thought that maximum contact stresses within this region cause Type 1 and Type 2 defects to open or become more pronounced. This in turn will increase the local concentration of oxygenating material as it will be present in these defects and voids where surface areas are greater for oxidative reaction. We therefore hypothesise that these fusion defects are the cause for the early failure of the Kinemax implants.


G M Whatling M Larcher P Young J Evans D Jones S A Banks B J Fregly A Khurana A Kumar R W Williams C Wilson C A Holt

Introduction: Inaccuracies in kinematic data recording due to skin movement artefact are inherent with motion analysis. Image registration techniques have been used extensively to measure joint kinematics more accurately. The aim of this study was to assess the feasibility of using MRI for creating 3D models and to quantify errors in data collection methods by comparing kinematics computed from motion analysis and image registration.

Methodology : 5 healthy and 5 TKR knees were examined for a step up/down task using dynamic fluoroscopy and motion capture. MRI scans of the knee, femur and tibia were performed on the healthy subjects and were subsequently segmented using ScanIP(Simpleware) to produce 3D bone models. Registration of the models produced from fine and coarse scan data was used to produce bony axes for the femoral and tibial models. Tibial and femoral component CAD models were obtained for the TKR patients. The 3D knee solid models and the TKR CAD models were then registered to a series of frames from the 2D fluoroscopic image data (Figure 1) obtained for the 10 subjects, using KneeTrack(S. Banks, Florida) to produce kinematic waveforms. The same subjects were also recorded whilst performing the same action, using a Qualisys (Sweden) motion capture system with a pointer and marker cluster-based technique developed to quantify the knee kinematics.

Results: The motion analysis method measured significantly larger frontal and transverse knee rotations and significantly larger translations than the image registration method.

Conclusion: The study demonstrated that MRI, rather than CT scan, can be used as a non-invasive tool for developing segmented 3D bone models, thus avoiding highly invasive CT scanning on healthy volunteers. It describes an application of combining fine and coarse scan models to establish anatomical or mechanical axes within the bones for use with kinematic modeling software. It also demonstrates a method to investigate errors associated with measuring knee kinematics.


JR Fountain C Jakaraddi J Pope JS Davidson AJA Santini

We present a prospective trial examining the effect of posterior tibial slope at total knee arthroplasty (TKA) on the range of movement and functional outcome.

Current literature shows little difference clinically in TKA with increasing posterior tibial slope. Previous studies have been retrospective or involved small numbers and may represent poor ligament balancing or inaccurate alignment.

In a prospective, double-blinded, randomised controlled trial, 250 patients undergoing primary Profix TKA, were randomised to receive either a 0 or 4 degree posterior tibial cut. Range of movement (ROM) was measured pre-operatively, at 3 months and 1 year by a single clinical physiotherapist. SF-12 and WOMAC scores were calculated at the same visit. Both patient and physiotherapist were blinded to the angle of tibial slope.

Mean one year post operative ROM was greater by 2 degrees (p=0.470) in those with a 4 degree tibial slope. Post operatively both groups had significant improvement in functional outcome scores. A 0.2 (p= 0.892) and 0.51 (p= 0.707) greater improvement in SF12 physical score and mental scores respectively was found in the 0 degree group at one year. There was also a 1.09 (p=0.718) greater improvement in WOMAC score with a 0 degree slope.

In conclusion increased posterior tibial slope gives a marginally better but non-significant post operative ROM and makes no significant difference to functional outcome.


F S Hossain S Patel J Tahmassebi F S Haddad

Aim: To ascertain if a medial rotation platform knee replacement design (MRK; Finsbury Orthopaedics) exhibits improved range of motion (ROM) and functional outcome compared to a conventional single radius condylar knee replacement system (PFC Sigma; Depuy) at one year.

Methods: Eighty patients undergoing total knee arthroplasty(TKA) were prospectively randomised and allocated to either receive the MRK or PFC Sigma pros-thesis. Patients were blinded to the choice of implant. Follow-up clinical and radiological evaluations were carried out by a single clinician so as to avoid interob-server error. Validated patient based scores including the Total Knee Function Questionnaire (TKFQ) were used to assess patient function.

Results: The average ROM in the MRK group was 108.53°. In the PFC Sigma group it was 94.16°. Statistical significance was demonstrated between the two groups.

The MRK group showed superior results in the TKFQ score which assesses activities of daily living as well as recreational and sporting activities. The movement and lifestyle component of the TKFQ, and the Knee Society Score were better in the MRK group with statistical significance.

No difference was demonstrated between the two groups with respect to radiological analysis, WOMAC Knee, Oxford Knee and SF-36 scores.

6 out of 40 patients in the MRK group compared to 5 out of 40 patients in the PFC group said that they had forgotten about their TKA at one year.

Conclusions: The medial rotation platform design confers increased ROM at one year with an associated benefit in movement and lifestyle and resultant patient satisfaction.


A Karim AMJ Bull O Kessler NP Thomas AA Amis

AIMS: To determine the effects of tibial component rotation and posterior slope on kinematics following Scorpio CR navigated TKR in cadaver specimens.

METHODS AND RESULTS: Knee kinematics were monitored using a validated IR Navigation System. Ten normal comparable cadaver specimens were mounted in a custom rig allowing assessment of kinematics under various loading conditions. The specimens then underwent Navigated TKR. The surgery was performed as per normal operating surgical protocols by an expert knee surgeon. However an augmented tibial component was implanted allowing the researchers to precisely modify its rotation and posterior slope. A pneumatic cylinder attached to the quadriceps tendon was then used to repetitively flex and extend the knee with a variety of applied loads.

Kinematics were different after TKR. Increasing posterior slope resulted in increasing posterior position of the femur, particularly at maximum flexion. Posterior slope also resulted in a deviation of the neutral path of motion and alteration of the normal envelope of laxity. Tibial component malrotations over 5 degrees resulted in deviations of the neutral path of motion without affecting the envelope of laxity. Combined malrotations over 10 degrees with posterior slopes over 6 degrees resulting in prosthetic subluxation under certain loading conditions.

Discussion: Knee kinematics are different after TKR. Increasing internal and external tibial component malrotation as well as the addition of posterior slope resulted in deviations of TKR kinematics through alteration of the neutral path of movement and or the envelope of laxity. Combined misalignments of slope and rotation resulted in the greatest deviations from normal kinematics and in some cases, prosthetic subluxation. Incompatibilities of alignment may result in increased ligament tension and component articulation dysfunction that may contribute to premature wear and loosening. Surgeons should be aware of this when considering the addition of posterior slope or assessing tibial component positioning in TKR.


R Maheshwari A Siegmeth

Purpose: In order to determine the incidence of allogenic blood transfusion in patients undergoing primary total knee arthroplasty (TKA) at our centre, we performed a retrospective analysis of prospectively collected data for all patients who underwent TKA between 1 April 2006 and 31 March 2008.

Methods and Results: In 2006/2007 there were 650 primary TKA patients (group 1) and in 2007/2008 this increased to 841 (group 2). Allogenic blood transfusions were administered according to hospital policy. The transfusion threshold was haemoglobin of 8g/dl or less or a symptomatic patient. For transfused patients data were collected for haemoglobin levels (pre-operative, post-operative and pre-discharge), duration of operation, ASA grade, number of transfusions, use of tranexamic acid and suction drains, and relevant clinical data including post-operative medical and surgical complications.

In group 1 27 patients were transfused (group 1T) and in group 2 10 patients were transfused (group 2T). This was a significant reduction in allogenic blood transfusions (4.5% vs. 1.2%, p < 0.001). The two transfused groups were similar with respect to age, gender, ASA, BMI, duration of operation, pre- and post-operative haemoglobin and tranexamic acid usage. In group 1T, the usage of suction drains was greater than in group 2T (48% vs. 20%) although this was not statistically significant (p = 0.27).

Conclusion: This study indicates that a low rate of allogenic blood transfusion can be achieved by using tranexamic acid and minimising insertion of suction drains. To the best of our knowledge, we report the lowest rate of allogenic blood transfusion for primary TKA. Our data have important implications in the management of patients undergoing TKA, particularly with respect to the need to cross-match all patients.


V Upadhyay A Sahu R Sharma W Farhan TK Kumar

Purpose of the study: Our aim was to look at, how we are following the British Orthopaedic Association (BOA) guidelines regarding the clinic times. The decrease in doctor working hours and increase in sub-specialisation has added to the problem.

Methods: 55 Orthopaedic clinics were observed and time mapped to the nearest second by an independent observer. 5 clinics observed for each of 11 clinicians (5 Consultants and 6 Registrars). The patient factors viz age, sex, mobility, BMI, site of disease were recorded. The clinician factors viz. seniority, sub-specialisation were also recorded.

Results: Of total Clinic time, 45% spent for consulting follow-up cases, 26% for new cases and 29% lost in in-between patient transit time. Of the total clinic time, patient time was 75%, procedures 4%, investigations 3%, consent 4%, dictation 13%, teaching 1%. Mean time for consultation was 13 minutes 6 seconds for new and 8 minutes 43 seconds for follow up patients which was significantly less than that recommended by BOA guidelines (15 – 20 minutes for new and 10 –15 minutes for follow up patients).

Conclusion: Since the British Orthopaedic Association (BOA) guidelines in 1990, there has been a change in patient’s expectation, responsibility of the clinician towards well informed patients, detailed investigation, consenting in clinics etc. Despite the clinics over running in time the BOA guidelines are not being adhered to potentially compromising quality consultation and training at the cost of pressures to see the recommended 22 unit patients per clinic. There is a need to revise BOA guidelines regarding clinics to provide more time in clinics per patient to maintain quality of care and training.


L McGonagle S Hakkalamani F A Carroll

Introduction: Reinfusion drains are used to minimise the need for allogenic blood transfusion, and its potential complications. Tranexamic acid {TA} is an antifibrinolytic agent that is used to decrease blood loss in total knee arthroplasty surgery. The effect of TA on reinfusion volume of drained blood has received little attention. The aim of our study is to measure the effect of TA on reinfusion volumes in primary total knee replacement {TKR}.

Methods: A cohort of consecutive patients undergoing primary total knee replacement between November 2006 and January 2008 were studied. Each patient was operated upon by the same surgeon, and had the same pros-thesis inserted. Patients operated upon before June 2007 did not receive TA but had reinfusion drains, while those who underwent surgery after June 2007 received TA along with the reinfusion drain. We measured pre and post operative haemoglobin {Hb}, drainage volume and reinfusion volume. The need for allogenic blood transfusion was recorded. TA and non TA groups were compared.

Results: Seventy patients were included in the study. There was no significant difference between the TA and non TA groups in pre operative Hb {13.2, 13.1g/dl} or post operative Hb {10.95, 10.9}. There was a significantly lower drainage volume {250 v 600ml} and subsequent reinfusion volume {100 v 465ml} in the TA group versus non TA groups respectively. There were no cases of thromboembolism or allogenic blood transfusion in either group.

Conclusion: Tranexamic acid significantly decreased post operative blood loss and subsequent reinfusion volumes in TKR. TA and reinfusion drains greatly decrease the demand for allogenic blood transfusion. Drainage volume is so low when TA is used in routine primary TKR, that the need for reinfusion drains is questionable. TA is cost-effective compared to reinfusion drains in TKR.


M Rashid R Squires A Khaleel

Aims: To compare rates of blood transfusion post knee arthroplasties for patients treated with and without tranexamic acid (TA) and assess for any haemoglobin change perioperatively between the groups.

Methods: This retrospective observational study included 207 patients undergoing primary unilateral knee replacement surgery who were divided by administration of TA intraoperatively (n=120) or without (n=87). The TA group was further subdivided into patients undergoing a standardised autogenic retransfusion procedure (n= 86) and those without (n=44). Case notes and laboratory results were used to study pre and post operative haemoglobin, administration of TA and blood products. The exclusion criteria consisted of patients in ASA classes III & IV, revision surgery, and patients undergoing bilateral or unicompartmental knee replacements. Analysis of haemoglobin change was undertaken using the student t-test. Significance was concluded when p < 0.05.

Results: The average haemoglobin drop in the TA group (without auto-transfusion) was 1.96g/dL versus 1.8g/dL in the no drug group which was not significant (p= 0.459). The average drop in the TA group (with auto-transfusion) was 1.78g/dL, also not significant (p=0.922). 3 of the 44 patients (7%) from the TA group (without auto-transfusion) required blood transfusions compared against 7 of the 87 non tranexamic acid group (8%) which was not significant.

Conclusion: There was no significant difference between all three groups. This study raises questions over the efficacy of TA treatment as a means to reduce perioperative blood loss in total knee replacements. Further, TA does not reduce blood loss and transfusion requirements even when autogenic retransfusion was used.


A S Rajeev S Senevirathna N S S Kashyap

Knee arthroscopy is the most commonly performed orthopaedic operation world wide. There is however little data on the incidence of DVT and consequently there is no consensus regarding the need for periopeartive thromboprophylaxia. Hoppener et al,2003 reported a high incidence of 11% DVT without the use of thromboprophylaxis.

The aim of our study was to establish the incidence of venous thromboembolic complications in day case knee arthroscopy without any thromboprophylaxis

A retrospective review of 458 consecutive knee arthroscopies done in our unit between Feb 1998 to May 2007 were carried out. They were all day cases and did not receive any chemical thromboprophylaxis. All the case notes were carefully scrutinized for any readmissions for symptoms of venous thromboembolism(VTE). The clinical signs documented were pain, tenderness, swelling or redness of the legs, dyspnoea, chest pain and haemoptysis leg pains or redness following the surgery.

There were 278 males and 180 females. The age group ranged from 15 to 88 years. The average age group was 57.7years. The primary out come of the study was the incidence of symptomatic and asymptomatic venous thromboembolic complications after the knee arthroscopy during the 2 week and 8 week followup period. Our study showed there were no cases of symptomatic deep vein thrombosis in any of the patients.

The pooled overall estimate of the incidence of all VTE, without the use of thromboprophylaxis was 7.4%, symptomatic 2% and asymptomatic 5.4%. This is not in agreement with our study. The limitation of our study, it is a retrospective analysis and no investigative tools were used.

We conclude that until more extensive studies have been performed, it seems justified to withhold thromboprophylaxis in patients undergoing uncomplicated knee arthroscopic procedures in a daycare setting..


R S Kotwal A Scholz A Robertson M C Forster

Purpose of the study: The aim of this study was to determine risk factors for clinically relevant pulmonary embolism (PE) in patients undergoing elective knee arthroplasty.

Methods and results: We performed a retrospective analysis of 956 total knee arthroplasties performed at our institution between June 2007 and May 2008 to identify patients with postoperative PE confirmed by computed tomography pulmonary angiogram (CTPA). All patients had received foot pumps, thromboembolism deterrent stockings and 75mg of Aspirin postoperatively. Patients with PE were matched for age, gender, surgeon, date and type of surgery with a control group of 32 patients. Patients case notes were reviewed to identify known risk factors for PE such as age, gender, ASA grade, BMI, medical comorbidities, pre-operative haemoglobin (Hb), postoperative Hb, drop in Hb, day mobilised postoperatively, tourniquet time and temperature in the postoperative period. Statistical analysis was performed using Statistical Package for the Social Sciences version 12.0 (SPSS Inc., Chicago, Illinos).

Twenty one (2.2 %) cases were identified with CTPA confirmed PE. Of the various risk factors studied, delay in postoperative mobilization was the only significant risk factor for PE (p=0.019). None of the other risk factors were significant for PE. Postoperative pain was the commonest reason for delayed mobilisation followed by lower limb paraesthesia from regional nerve blocks.

Conclusion: We found that a delay in postoperative mobilization was the most significant risk factor for clinically relevant PE in our patient population following knee arthroplasty. The use of chemical thromboprophylaxis for all patients undergoing elective knee arthroplasty is currently under debate. Not all patients are at equal risk, however, and chemical prophylaxis is not devoid of complications. Early postoperative mobilization of all patients may help prevent this potentially fatal complication.


G Williams

Introduction: Failure to meet rehabilitation targets after total knee replacement is the main reason for delayed discharge in our orthopaedic unit. Low haemoglobin levels are associated with increased length of stay possibly due to poor participation in physiotherapy and delayed attainment of the functional goals necessary for safe discharge. This report describes the rehabilitation of patients with post operative haemoglobin levels between 7.1–8g/dL and provides a comparison with individuals rehabilitating with much higher levels.

Materials and Methods: Case notes of 64 primary total knee replacements over the period January – October 2007 (10 months) were reviewed in a comprehensive retrospective analysis. All aspects of care were standardised. Joint replacements were performed using recognised surgical techniques and implants.

Patients were given access to a minimum of two physiotherapy sessions each day, 6 days a week. Typical gait re-education began with the delta rolator frame progressing to walking sticks, stair assessment and finally discharge. Care pathways, operative and medial notes were reviewed for postoperative haemoglobin levels, complications and achievement of functional physiotherapy targets.

Results: 8 of 64 patients were found to have a postoperative haemoglobin level bellow 8g/dL (sample average 10.2g/dL). 3 of these patients underwent transfusion for levels bellow 7g/dL and were excluded from further analysis. 5 patients began rehabilitation with haemoglobin levels between 7.1–8g/dL. All 5 mobilised with the delta frame on post op day one, progressed to sticks between days two to four and managed a stairs assessment on postoperative days two to five with an average inpatient stay of six days.

Conclusion: These gains were almost identical to the overall sample average suggesting that in isolation, haemoglobin levels between 7.1–8g/dL do not significantly impede postoperative rehabilitation. It would seem there is no justification for ‘top up’ transfusions to expedite rehabilitation after joint replacement surgery in this patient group.


A S Desai A Karmegam T N Board V V Raut

Introduction: Stiffness is a disabling problem following TKR surgery. The overall incidence is 1–3%. Though multiple factors have been implicated in development of stiffness, it still remains an incompletely understood condition. Furthermore, opinion is divided about the efficacy, timing and the number of MUA’s post TKR surgery, as there are no definitive guidelines.

Aims & Objectives: The aim of this study was to assess the predisposing factors for stiffness following TKR surgery, to determine the efficacy of single and multiple manipulations and to investigate the most appropriate timing for manipulation.

Material & Methods: We retrospectively reviewed 86 patients who underwent manipulation for stiffness post-primary TKR surgery with at least one-year follow up. The number of manipulations, predisposing factors, the flexion gain at different intervals, final gain in flexion and range of movement was noted till the end of 1 year.

Results: Results were assessed by timing and number of MUA’s performed. Sixty five patients underwent single MUA and 21 had multiple MUA. At the end of one year the single MUA group showed 310 of sustained gain in flexion and in the multiple MUA group only 90 flexion gain was noted (p=0.003). MUA within 20 weeks of primary surgery showed 300 of flexion gain, whereas only 70 of flexion gain was seen when MUA was undertaken after 20 weeks (p=0.004). Patients on warfarin (9.5%) and with previous major surgeries to the knee prior to TKR (11.5%) had increase incidence of stiffness and poor flexion gain.

Conclusion: The timing of the 1st MUA is crucial, with better results achieved in MUA performed less than 20 weeks (particularly between 12–14 weeks) from primary surgery. Age, sex and type of disease do not influence the severity of stiffness in this study. There appears to be no added benefit in re-manipulation.


A Sahu T Wilson SJ Anand DS Johnson PG Turner

Purpose of the study: What is the effect on the length of a procedure and the number of procedures performed on the list when a trainee is involved? What percentage of cases had trainee involvement for orthopaedic surgery?

Methods: Data was taken from two different sources, firstly, the ORMIS theatre system and patient operation notes. These were used to determine the length of six different types of orthopaedic procedures and the level of the main surgeon. The second source used was a consultant’s logbook comprising 227 primary total knee replacements between 2004 and 2008.

Results: The data collected via the ORMIS system produced trends suggesting trainees took longer to perform procedures than consultants. The data from the consultant logbook statistically proved this. List times appeared unaffected by trainee presence. In Orthopaedic surgeries, 92% times trainees were present during the procedure and out of this 17% cases were performed by trainees. For total knee replacements done by trainees the procedure took significantly longer surgical time than consultant performed procedures (p = 0.0337).

Among these cases, 71% were performed by senior trainees. The consultant’s log book data also suggested the similar trends. Statistically, trainee performed with consultant scrubbed versus consultant performed (P = < 0.0001), trainee performed with consultant in theatre versus consultant performed(P = 0.0318) and trainee performed with consultant scrubbed versus trainee performed with consultant in theatre (P = 0.002)

Discussion & Conclusion: To train the surgeon adds to the length of procedures and this is currently not accounted for, in the finance received to perform the operation by the hospital.

To counter this, training hospitals should be given financial incentives to train in surgery, or procedures performed by trainees should be priced differently to account for the time lost by training.


R S Kotwal N Prasad R Morgan-Jones

Purpose of the study: The purpose of this study is to present our initial experience of single stage revision surgery for infected total knee arthroplasty (TKA).

Methods and results: 12 patients underwent single stage revision for infected TKA. The average patient age was 72.5 years and M: F was 2:1. 5 of the 12 patients had frank infection with presence of discharging sinuses pre-operatively. The procedure involved explantation, debridement, subtotal synovectomy, use of high pressure carbon dioxide (Carbojet) and re-implantation using revision prosthesis and antibiotic laden cement. Utmost care was taken to restore the balance and stability of the revised knee. All the patients were given appropriate intravenous and oral antibiotics in the peri-operative period. Oxford knee scores (OKS) were obtained pre-operatively and at the latest follow-up. Patient satisfaction was also assessed.

At the latest follow-up, none of the patients had recurrence of the infection nor did they need any further surgical procedure. There was no radiographic evidence of loosening of the prosthesis. The OKS had improved from a mean of 17 pre-operative to 41 at the latest follow-up. All the patients were extremely satisfied with the outcome.

Conclusion: Knee function and patient satisfaction improved significantly after single stage revision for infected TKA. None of the patients needed further surgery in the short term. Early results are very encouraging and this change in practice may save on costs and patient morbidity associated with the second stage.


A Sahu N Nazary NS Harshavardana SJ Anand DS Johnson

Purpose: Our aim of this study was to find out the abstract to publication ratio (APR) in peer-reviewed indexed journals of abstracts presented at BASK annual meetings. We also wanted to identify the publishing journals and to look at the amount of time taken for publication.

Methods: We obtained permission from BASK executive committee and retrieved all presentations (podium & poster) over six year period (2000–2005). An extensive PubMed database search was performed to determine whether or not the abstract had been published as a full paper up to the beginning of Nov 2008.

Results: A total of 294 abstracts identified, 114 of them were published as 101 full-text articles in 21 different journals. ‘The Knee’ Journal was the most popular destination with 47 publications (41.2%) followed by JBJS (British) with 28 publications (24.5%). The overall abstract to publication ratio (APR) at BASK annual meetings was 38.77%. The mean duration between presentations to publication was 3.96 yrs (range 0 to 7.2 yrs, median 3.4 yrs).

Conclusion: On bench marking the APR ratio at BASK presentations, it is comparable with those of BOA (33.1%), other BOA affiliated societies (26–50%) and medical specialties (32–66%). Abstract to publication ratio (APR) is considered as a measure of the quality of scientific meetings and our results indicates the higher credentials of BASK meetings. It is very difficult to exactly determine the reason for abstracts failing to indexed publications; it is arguable that some of these projects did not meet the scientific scrutiny of the peer-review process required for full publication. We recommend authors to submit the full manuscript of paper after acceptance of their abstracts for the BASK meeting as done in AAOS meeting in order to encourage them to complete their manuscript before presentation.


N Prasad V Peringe R Kotwal A Ghandour R Morgan Jones

Aim: To review our practice of performing two-stage revision for infected total knee arthroplasty by using articulating interval prosthesis and short course parenteral antibiotic therapy

Patients and Methods: We included 70 patients treated by a single surgeon using a uniform protocol since 2001. All patients were planned to have two- stage revision for infected total knee arthroplasty with an articulating interval prosthesis made up of cruciate retaining femur and all poly tibia at stage one. All patients were given short course parenteral antibiotic therapy (5 days IV) followed by and 6 weeks dual oral therapy.

Results: The average age was 68 yrs at the time of first stage. Five patients required repeat of 1st stage procedure because of persistent infection. Twenty six (40%) patients opted not to have a 2nd stage procedure because of eradication of infection after 1st stage and good functional result with interval prosthesis. We had recurrence of infection in 6 patients after two-stage procedure at a mean follow up of 42 months. Four patients out of these six had multiple surgeries for infection before our two-stage protocol

Conclusion: Articulating interval prosthesis gives excellent function and also makes subsequent revision easier with well preserved soft tissue balance. It also takes pressure off on the time constraint for the 2nd stage and good number of them may not require a 2nd stage at all. Our results of recurrence are comparable with published literature evidence and we don’t think that prolonged parenteral antibiotics therapy is required provided adequate surgical debridement has been performed.


C K Tan S Panchani V Selvaratnam R H K Tan P B Carter G J Kemp

Introduction: Intra-articular steroid injection has long been used to treat osteoarthritis of the knee and hip by orthopaedic surgeons, rheumatologists and general practitioners. Recent literature has shown conflicting results with regard to its safety. We aimed to investigate whether a relationship exists between preoperative intra-articular steroid injection and postoperative infection in total knee arthroplasty (TKA).

Patients and Methods: We reviewed the records of all patients having TKA between April 2005 and April 2007 in University Hospital Aintree, Liverpool. The operations were carried out by 6 consultants. Exclusion criteria for analysis were: previous knee infection, revision knee surgery, fracture around the knee, skin disorders, diabetes, blood transfusion, rheumatoid arthritis and immunosuppressive medication. Eligible patients were divided into two groups: group I had received intra-articular steroid injection (each subject receiving 1–3 (mean 1.6) injections between 1–12 (mean 5) months before TKA); group II had received no injection. Mean follow-up was 17 months.

Results: 425 patients had TKA, of which 361 met our criteria. 121 patients in group I and 240 patients in group II. No-one in group I developed acute infection. In group II, 7 patients developed acute infection (5 superficial and 2 deep) between 1 and 6 weeks (mean 3.7 weeks) post-operatively. There were no late infections. The difference in infection rate between groups I and II was not statistically significant (P=0.1, Fisher’s exact test).

Conclusion: We found no evidence that intra-articular steroid injection prior to TKA increased the incidence of postoperative infection.


M A McCleery M J Chambers W J Leach T Norwood

Aims: To determine the rate of early and late infection amongst patients with renal disease undergoing TKA.

Methods and Materials: Review was undertaken of the Scottish National Arthroplasty Project data for the period from April 1985 to March 2008. Data was examined for the rate of infection amongst patients under-going TKA with a diagnosis of renal transplant, renal dialysis or renal failure. Early infection was classed as occurring within 90 days of the index procedure and late infection as occurring after 90 days. Renal failure, dialysis and transplant were identified using ICD 9 and 10 codes. The 4th revision of the OPCS codes was used to search for renal transplant, renal dialysis and knee arthroplasty.

Results: In total, 59288 TKAs were performed in Scotland over the period analysed. There were 651 early infections and 1296 late infections giving overall early and late infection rates of 1.1% and 2.2% respectively. 10 patients had renal transplant prior to TKA with 1 early infection (infection rate 1%) and no late infections. 44 patients had a renal transplant before or after TKA with 1 early and 6 late infections giving an early infection rate of 2.27% and late infection rate of 13.64% for this group. 17 patients undergoing renal dialysis underwent TKA with no early infections but a single late infection, giving a late infection rate of 5.8%. 2920 patients had a diagnosis of renal failure prior to or after TKA with 48 early and 138 late infections. Infection rates for this group were 1.64% early and 4.73% late.

Conclusions: TKA patients with renal transplant, renal failure or undergoing dialysis are at increased risk of infection. In particular, renal transplant patients are most at risk of late infection. Renal patients must be counselled of these increased risks prior to orthopaedic or transplant surgery.


A Alani C Esler

Purposes of the study: Demographic s Description and Pattern Recognition.

Methods: We reviewed the revision total knee replacements performed between 2001 and 2005, which were recorded on the Trent and Welsh knee register. We looked at the total number recorded in the register, the number of operations entered every year and the performance of each of the hospitals on the register through the 5 years period. We looked as well at the male: female ratio, the median age of revisions, the side of the operation, whether the implants were cemented or not and the seniority of the operating surgeon.

Results: Total number of revisions between 2001–2005 was 662. In the year 2001 we had 69 revisions, in 2002 we had 129 revisions, in 2003–2004 we had 201 revisions and in 2005 we had 263 revisions.

Out of the grand total of 662, 3 were form Bangor hospital, 10 were from Barnsley, 20 were from Basset-law, 2 were from Cardiff, 1 was from Claremont, 38 were from Derby, 18 were from Doncaster, 138 were from Leicester, 1 was from Glan Glwyd, 17 were from Grantham, 121 were from KMH, 2 were from Lincoln, 23 were from Llandough Hospital, 131 were from NGH, 86 were from Nottingham City, 2 were from Parkhill Hospital, 1 was from Pilgrim Hospital, 2 were from Prince Phillip Hospital, 4 were from QMC, 28 were from Royal Gwent, 2 were from Rotherham, 1 was from Thornbury Hospital, 4 were from WWG, 3 were from WWQ. The rest of the revisions were anonymous to place.

344 cases were males, 304 were females and the rest were anonymous.

The average age for males was 74 years and the average age for females was 75 years.

330 operations were carried out on right knees, while 302 were on the left side. The rest were anonymous.

491 revisions were carried out by Consultants, 19 were carried out by a Staff Grade, 37 were carried out by Registrars, 28 were carried out by others and the rest were anonymous. To be noted is that in 414 revisions the surgeons had no assistant.

253 knees were cemented, 10 were marked as uncemented and the rest were anonymous. Bone Grafts were used in 71 patients and augments were used in 107.

Conclusions: The input of the numbers of revisions has improved over the years. Poor documentation of whether the implant was cemented or not. 84 revisions were performed by Trainees/Staff Grades, does this have an impact on the outcome?. In 414 revisions the consultants didn’t have an assistant, this should not occur as revisions are complex operations and the lack of an assistant might have an impact on the outcome.


R S J Nickinson T N Board A K Gambhir M L Porter P R Kay

Aim: To identify the microbiology of infected knee arthroplasty, emerging patterns of resistance over the last decade, and suggest appropriate empirical treatment.

Methods: A retrospective analysis was conducted of 121 patients with microbiologically proven infection, who underwent revision TKA between 1994–2008. The causative organism was identified from microbiological samples and the corresponding sensitivities recorded. The data was then collated to determine the most common causative organisms, changing patterns of antibiotic resistance over the time frame, and the antibiotics currently most effective at treating deep infection. A theoretical model combining gentamicin with other antibiotics was used to determine the most effective antibiotics for use as empirical treatments.

Results: Coagulase negative Staphylococcus (CNS) was the most common causative organism (49%). Staphylococcus aureus (SA) accounted for 13% of cases. The prevalence of CNS appears to be increasing, while that of SA and other organisms is decreasing. Vancomycin and teicoplanin were the most effective antibiotics with overall sensitivity rates of 100% and 96% respectively. Levels of resistance were significantly higher among the antibiotics more commonly used in the community. Antimicrobial resistance was higher when the causative organism was CNS, suggesting that multi-drug resistant CNS is becoming a problem in knee arthroplasty. Our theoretical model showed that gentamicin combined with vancomycin would be the most effective empirical treatment.

Conclusion: Understanding the microbiology of deep infection of the knee allows surgeons to treat this complication as effectively as possible. Vancomycin and teicoplanin appear to be the most effective antimicrobials, with relative invulnerability to the development of resistance. Given the effectiveness of these antibiotics, the use of vancomycin in gentamicin bone cement, combined with IV teicoplanin potentially allows for infected knee arthoplasties to be treated with a one-stage procedure. The rational use of antibiotics may help limit the amount of antibiotic resistance which develops in the future.


Y Fortems

Purpose: Characterized chondrocyte implantation (CCI) uses an autologous cartilage cell population capable of making stable cartilage in vivo. Despite comparable short-term improvement after intervention, clinical follow-up was to determine long-term clinical benefit of CCI in the repair of full-thickness knee cartilage lesions.

Methods: In a randomized controlled clinical trial comparing CCI to microfracture, patients with single ICRS grade III/IV symptomatic defects of the femoral condyles were randomized to receive either treatment (n=57 vs. n=61, respectively). Clinical improvement was measured up to 36 months using the KOOS, Visual Analogue Scale for knee pain (VAS) and Activity Rating Scale (ARS). Treatment failures and safety were monitored throughout.

Results: At baseline, KOOS was comparable between treatment groups (Mean ± SD: CCI, 56.30 ± 13.61; microfracture, 59.53 ± 14.95); improvement from baseline in adjusted mean ± SE of the overall KOOS at 36 months was 21.25 ± 3.60 for the CCI group and 15.83 ± 3.48 for the microfracture group. In a mixed linear model (with LOCF imputation), significantly greater improvements were shown for CCI vs. microfracture in change from baseline in all KOOS domains (p-value for the Overall KOOS = 0.0007) except for ‘Sports’. Between-group improvements from baseline to month 36 in VAS and ARS scores were similar. For CCI and micro-fracture groups, the percentages of treatment responders (improvement of 10 percentage points or more) were 83% (n = 34 of 41) vs. 62% (n = 31 of 50) on the KOOS and 83% vs. 66% on the VAS. Time to treatment failure was not statistically significant between the groups (n CCI/MF = 7/9). There was no change in safety profiles in comparison to the previous recorded data.

Conclusions: The initial superior structural outcome with CCI after 12 months post-surgery was substantiated by superior clinical benefit at 36 months compared to microfracture.


R S Kotwal K Brakspear C Wilson R Williams D J Mason

Purpose of the study: Since glutamate can activate both nociceptive and pathological processes, we have investigated glutamate signalling in patients with painful and asymptomatic meniscal tears to determine which components are expressed, whether this varies in different anatomical regions of the meniscus and whether it is influenced by pain or degeneration.

Methods and results: Meniscus samples were obtained from two patients undergoing arthroscopic partial meniscal resection for chronic degenerate painful meniscal tears, from one patient with a torn painless meniscus and from the less affected compartment of the knee joint of three patients undergoing total knee arthroplasty. Menisci were dissected into anatomical regions (anterior horn, body, posterior horn, inner vascular, outer avascular), cryosectioned and RNA extracted. RNA was reverse transcribed and PCR performed for the housekeeping gene GAPDH and glutamate receptor subunits (NR2A, AMPA GluR3, KA1). Absolute quantitative RT-PCR assessed mRNA expression of glutamate transporters (EAAT-1, EAAT-1ex9skip) and type I collagen after normalisation to GAPDH or total RNA.

Human meniscus expressed GAPDH, type 1 collagen, EAAT-1, EAAT-1ex9skip, NR2A, AMPA GluR3 and KA1 mRNAs. Levels of EAAT-1 expression, normalised to GAPDH, did not differ between the inner and outer halves, or in the anterior, middle or posterior regions of menisci from the less affected compartments of arthritic knees. EAAT-1 expression appeared greater in the 2 painful, compared with the single non-painful meniscus. Interestingly, EAAT-1ex9skip was significantly more common within the outer zones (ANOVA, P=0.040) and in the posterior horns of the menisci (ANOVA, p=0.038).

Conclusion: We have shown for the first time that glutamate receptors and transporters are expressed in human meniscus providing a potential mechanism underlying the pathophysiology of pain associated with a torn meniscus. Our preliminary data indicate that EAAT-1 and EAAT-1ex9skip expression may vary with extent of damage and anatomical location in the human meniscus.


A Datta M David K Baloch

Unicompartmental knee replacement (UKR) is an increasingly popular alternative to total knee replacement in medial compartment disease. Early problems include unexplained pain, stiffness, infection and technical errors leading to dislocation of bearing or fracture. This study is the first to highlight re-intervention as an outcome measure when assessing the success of a partial joint replacement.

All Oxford UKRs undertaken at ROH during November 2002 and December 2007 were reviewed to identify patients who required a further procedure.

383 UKRs were implanted. 21 (5.5%) patients underwent further re-intervention. Twelve (3.1%) were for persistent post-operative pain, three (0.8%) for stiffness and six (1.6%) had a combination of symptoms. one re-intervention was for a tibial plateau fracture. Initial re-interventions included eleven arthroscopies and three manipulations.

Nine (2.4%) patients subsequently underwent revision procedures, eight to a total knee replacement with one revision to a fixed bearing unicompartmental prosthesis. There were no revisions for infection. Manipulation improved stiffness in all the patients. Outcome following re-interventions for persistent pain were less predictable. Arthroscopy improved symptoms in only 36% of patients but eight of the nine (88.9%) patients that were formally revised had an improvement in symptoms.

Our early re-intervention rate of 5.5% and the out-come of subsequent surgery provides a valuable evidence based resource to discuss potential post operative expectations and complications with patients awaiting an Oxford UKR.


P.D. Gikas R. Carrington J. Skinner T.W.R. Briggs G. Bentley

Introduction: Autologous Chondrocyte Implantation (ACI) is a treatment option for full-thickness chondral, or osteochondral injuries that are painful and debilitating. Goals of surgery and rehabilitation include replacement of damaged cartilage with hyaline or hyaline-like cartilage, leading eventually to improved level of function. Intermediate and long-term results are promising in terms of functional and clinical improvement.

Purpose: To explore the hypothesis that the quality of the repair tissue, formed following Autologous Chondrocyte Implantation (ACI), improves with time post-surgery.

Methods and Results: Two hundred and forty eight patients who underwent autologous chondrocyte implantation in our institution were studied after having had post implantation biopsies of the repair tissue. Mean timing of biopsy was 14.8 months (range 3–55). 59 biopsies gave hyaline tissue (24%), 67 mixed hyaline and fibrocartilage (27%), 113 biopsies were fibrocartilage only (46%) and 9 patients had a fibrous tissue biopsy result (9%). Due to NHS restraints and waiting list targets biopsies were actually performed at various time points post implantation allowing us to statistically correlate histological findings with the maturity of the repair tissue.

Our statistical analysis suggests that if time post implantation doubles then the likelihood of a favourable histological outcome increases significantly.

Conclusion: Autologous chondrocyte implantation forms a durable repair tissue that remodels and continues to improve in quality with time. It is recommended that for future research/study purposes 24 months is used as an optimal time to look at histology, since our data show that outcome is still improving until this point.


B J L Kendrick D Simpson N J Bottomley B Marks H Pandit D Beard H S Gill C A Dodd D W Murray A J Price

Purpose: This study was designed to establish the poly-ethylene wear rates in the Oxford medial unicompert-mental knee replacement.

Introduction: The Oxford meniscal bearing knee was introduced as a design to reduce polyethylene wear. There has been one previous retrieval study of the Oxford UKA, which reported very low wear rates in some specimens, but abnormal patterns of wear in others, including impingement. There has been no further investigation of these abnormal wear patterns.

Methods: Forty-seven bearings were retrieved from patients who had received a medial Oxford UKA for anteromedial osteoarthritis of the knee, none of which had previously been studied. Mean time to revision was 8.4 years (SD 4.1) and 20 had been implanted for over 10 years. The macroscopic pattern of polyethylene wear and the linear penetration (dial gauge measurement) was recorded for each bearing.

Results: The mean linear penetration rate (LPR) was 0.07mm/year. The patterns of wear fell into 4 categories, each with a different LPR; 1) No abnormal macroscopic appearance, n=16 (LPR = 0.01mm/year), 2) Abnormal macroscopic wear with extra-articular impingement, n=16 (LPR = 0.05mm/year), 3) Abnormal macroscopic wear with intra-articular impingement, n=6 (LPR = 0.10mm/year), 4) Abnormal macroscopic wear with impingement and signs of incongruous articulation, n=9 (LPR = 0.14mm/year). The differences in LPR were statistically significant (p< 0.05).

Conclusion: The results show that very low polyethylene wear rates are possible if the device functions normally. However if the bearing displays abnormal function (extra-articular, intra-articular impingement or incongruous articulation) wear rates increase significantly.


D J Mason K Brakspear C Wilson R Williams R S Kotwal

Purpose of the study: Since the neurotransmitter glutamate mediates nociceptive and pathological processes in arthritis, we have investigated how glutamate receptor and transporter expression varies with anatomical site or disease severity in subchondral bone of patients with osteoarthritis.

Methods and results: Subchondral bone was sampled from tibial cuts derived from total knee arthroplasty (n=2, TKR, Kellgren Lawrence grade 3) and from tibial drill hole sites from high tibial osteotomy (n=2, HTO, KL grades 2 and 3) for osteoarthritis. RNA was extracted, reverse transcribed and RT-PCR performed for the housekeeping gene GAPDH, the glutamate transporter EAAT-1, and glutamate receptors (NR2A and KA1). Quantitative RT-PCR assessed differences in the expression of EAAT-1, a dominant negative splice variant called EAAT-1ex9skip and osteocalcin after nor-malisation to GAPDH.

Good quality RNA was obtained from bone cores removed from drill holes during HTO surgery, with GAPDH, EAAT-1, NR2A and KA1 expression detected. Osteocalcin expression was high indicating RNA was derived from osteoblasts and osteocytes, but did not vary with anatomical site or disease status. End-stage RT-PCR indicated differential expression of EAAT-1 between medial and lateral bone samples in total knee arthroplasty, however these differences were not significant by quantitative RT-PCR. In one patient, EAAT-1 expression was significantly reduced in the anterior zone versus the middle or posterior zones (ANOVA, p< 0.001). EAAT-1ex9skip represented a significant proportion of the total EAAT-1 mRNA expression in bone from TKR patients, but appeared less abundant in HTO samples.

Conclusion: We have shown for the first time that glutamate transporters and receptors are highly expressed in subchondral bone of patients with osteoarthritis and that EAAT-1 expression may vary with anatomical location and pathology. Activation of these receptors and transporters by the increased synovial fluid concentrations of glutamate that occur in arthritis may contribute to pathological changes and nociception.


A Getgood R Brooks L Fortier N Rushton

Introduction: Platelet rich plasma (PRP) has been hypothesised to be of potential benefit to articular cartilage tissue engineering, through its release of autologous growth factors.

The aim of this study was to ascertain whether the addition of thrombin is required to achieve platelet activation and sustained growth factor release in-vitro, when PRP is applied to a collagen based osteochondral scaffold.

Methods: Collagen/glycosaminoglycan scaffolds were fashioned, to which equal combined volumes of test substances were added (n=3): 500μl PRP; 375μl PRP + 125μl autologous thrombin (3:1); 455μl PRP + 45μl bovine thrombin (10:1). One ml of DMEM/F12 medium was added to each scaffold and changed completely at 12/24 hours, and 3/10 days, following which release of TGF-β1, PDGF-AB and bFGF were measured using ELISA. Secondly, equal sized collagen/glycosaminogly-can and polylactide co-glycolide scaffolds were fashioned to which 500μl of PRP were added (n=3). Similar conditions were followed as previously except that only PDGF-AB was assayed.

Results: A similar cumulative release profile of all growth factors was found over the 10 day period. Greater growth factor release was seen in the PRP only group at all time points with PDGF-AB in particular reaching statistical significance at all time points (p< 0.006). These findings remained apparent when a correction for volume was made (p< 0.028) suggesting a particular role of the collagen in platelet activation. This was shown in the second experiment, in which a significantly increased cumulative volume of PDGF-AB was released from the collagen/glycosaminoglycan scaffold without thrombin activation (p< 0.04).

Discussion: This study shows that collagen is a potent activator of platelets, requiring no further addition to achieve satisfactory growth factor release when applied clinically. These results suggest that if PRP is combined with polylactide co-glycolide scaffolds, it should be activated with thrombin to achieve optimum growth factor release.


A Getgood R Brooks A Lynn T Simon H Aberman N Rushton

Introduction: Current treatment options for small, contained articular cartilage defects include microfracture, osteochondral autograft plugs or newer synthetic plugs. Chondromimetic is a novel biphasic biological scaffold composed of collagen and glycosaminoglycan. The addition of brushite provides the scaffold with a regionally specific component enabling the scaffold to mimic both phases of the osteochondral unit.

The aim of this study was to show the efficacy of Chondromimetic in repairing a surgically created osteochondral defect in a caprine model.

Methods: Osteochondral defects were made in the lateral trochlear sulcus (LTS) and medial femoral condyle (MFC) of nine goats. Chondromimetic scaffolds (6x6mm) were inserted into each defect (n=6), while three controls had defects left empty (n=3). All animals were sacrificed at 26 weeks postoperatively. Macroscopic evaluations and quantitative stiffness properties were assessed. Histological sections were taken at approximately the centre of the defect, stained with Safrinin O/Fast Green and scored using a validated quantitative assessment tool.

Results: Macroscopically, the repair tissue scored higher in the filled MFC and LTS (p< 0.05) compared to controls. In all defects, the mechanical stiffness was found to be within one standard deviation of native cartilage, except the LTS controls. Histologically, the predominant tissue in the cartilage layer was hyaline-like in three of six filled MFC defects, and five of six filled LTS defects according to the modified Sellers score. This was compared to one in three and zero of three in the MFC and LTS controls respectively.

Discussion: These results represent the early findings from an ongoing in-vivo study in which a further group of animals will be sacrificed at one year. At six months, the histology and mechanical properties are encouraging and should continue to improve with time. These results show that Chondromimetic may represent an acceptable alternative to marrow stimulation in the treatment of osteochondral defects.


AJ Price D Longino U Svard KT Kim P. Weber N Fiddian D Shakespeare G Keys D Beard H Pandit CAF Dodd DW Murray

Purpose: The purpose of this study was to report the mid-term survival results of Oxford UKAs in patients of 50 years of age or less, using (1) revision surgery and (2) Oxford Knee Scores (OKS) as outcome measures.

Method: A literature review identified studies of Oxford mobile bearing UKAs containing individuals 1) 50 years old or less with 2) medial osteoarthritis and 3) 2 years or longer follow-up. Authors were approached to participate in a multi-centre survival analysis by submitting all their patients, 50 years of age or less, who received a medial UKA for osteoarthritis. Patients who had died, been lost to follow-up or who underwent revision were identified. OKS were established for all patients with surviving implants.

Results: Seven centres submitted 107 patients. The mean age was 47 years (range 32–50). The average follow-up was 4 years (range 1–25). Forty-seven patients had follow-up into their fifth year or longer. The cumulative 7-year survival using revision as the endpoint was 96% (CI 8). The mean post-operative OKS for surviving implants was 38 (CI 2) out of a possible 48.

Conclusion: While early survival rates and function are encouraging, long-term follow-up is required before concluding UKA is a viable treatment option in young patients with unicompartmental knee arthritis.


J J Matthews K Williams G Mahendra D Mahoney C Swales A Sabokar A Price NA Athanasou C L M H Gibbons

Inflammatory changes in synovial tissues occur commonly in knee osteoarthritis (OA) and are termed “inflammatory OA”. The pathogenic significance of this inflammatory OA is uncertain. It is also not known whether inflammatory changes in the synovial membrane are reflected in the synovial fluid (SF) and whether the SF contains a similar inflammatory cell infiltrate.

This study examined 34 cases of knee joint OA and cytologically and immunohistochemically characterised inflammatory cells in the synovial membrane and SF. Specimens of SF and synovial membrane were taken at the time of knee arthroplasty.

All cases of inflammatory OA synovium contained (CD68+) macrophages; several cases also contained a scattered, focally heavy (CD3+) lymphocytic infiltrate and occasional lymphoid aggregates. Inflammatory changes in OA SF reflected this cell composition with numerous CD68+ macrophages and CD3+ lymphocytes being noted in inflammatory OA cases. The SF volume was greater (> 5ml) in cases of inflammatory OA. Non-inflammatory OA knee joints contained very few inflammatory cells, which were mainly macrophages, in both the synovial membrane and SF.

Our findings indicate that inflammatory changes in the synovial membrane of OA knee joints are reflected in the SF and that the volume of SF is commonly increased in cases of inflammatory OA. Both macrophages and lymphocytes in the inflammatory infiltrate of knee joint SF may contribute to joint destruction in OA by providing mononuclear phagocyte osteoclast precursors and the production of inflammatory cytokines and growth factors that promote osteoclastogenesis.

In conclusion, the cytology of SF and synovitic membrane are similar in inflammatory OA. With knee effusions of greater than 5mls and inflammatory synovitic membrane consideration of total knee arthoplasty in the presence of single compartment disease should be considered because of the risk of further joint destruction.


P Makrides MR Carmont M Dhillon P Thompson T Spalding

Purpose: To report on our early experience with a synthetic meniscal substitute inserted for symptomatic post meniscectomy medial or lateral knee pain.

Methods and results: Six patients underwent underwent insertion of a collagen meniscal implant (Menaflex, Hospital Innovations, UK). These were inserted onto a trephinated rim of vascular meniscus to permit the structural incorporation of healing tissue. Specific rehabilitation included 8 weeks on crutches and restricted activity for 6 months. Patients were prospectively analysed documenting KOOS, IKDC, Lysholm and SF36 outcome scores.

All patients were male, 4 patients had deficiencies in the right knee, 2 the left knee and the mean patient age was 28.8years (range 17–45). Four CMI were inserted for lateral meniscal deficiencies, two medial. The mean length of implant sutured in place was 41mm (range 35–55). Median pre op scores were KOOS P/S/ADL/QOL 53/100, 54/100, 66/100, 25/100, 44/100, IKDC 49.43%, Tegner 3, SF-36 35.38 PCS and 27.48 MCS and Lysholm 87/100. The mean elapsed time post meniscectomy was 20 months (range 2–51). All but one of the implants used were 9.5mm in width and sizes ranged 35–45mm.

At early follow up there have been no complications and background pain has improved in all 6. MIR imaging has shown that none have separated. Post operative follow up suggest improved outcome.

Conclusion: Though this is very early data, close scuritny of new treatment options is essential. So far the clinical outcome is favourable and we believe that CMI may be beneficial in reducing post menisectomy pain. Hopefully, in the future CMI may become a means of preventing post meniscectomy osteoarthrtitis.


S Needhi Rajan A Gandhe C M Fergusson

Aim: The purpose of this study is to evaluate the long term results of modified Elmslie-Trillat procedure. We have also reviewed the various modifications and its outcome seen in the literature to the original conventional Elmslie-Trillat procedure. Our modified surgical technique is described.

Materials and Methods: The patients were evaluated functionally using Kujala and Fulkerson scoring system. Clinical examination was performed to look for patella apprehension, tracking of patella, crepitus and range of movement. X rays were done to look for degenerative changes. The primary end point in our study was evidence of recurrent instability and the secondary end point was functional scoring and evidence of degenerative changes.

Results: Out of 38 patients and 42 knees available from our records from 1991 to 2005, 16 patients and 20 knees were available for functional and clinical review. The mean age at operation was 27 years. The average follow up was 9 years. 74% of the knees scored excellent to good with kujala and Fulkerson scoring. There was no episode of recurrent dislocation post-operatively in our series. Minimal degenerative changes were noted in 15% of knees. 37% of knees needed removal of screw. 58% of knee had some numbness around the scar. 80% of them returned back to original occupation. 60% of them went back to original sporting levels. All patients felt happy to recommend the operation.

Conclusion: We conclude that our modified Elmslie-Trillat surgical procedure is very successful in eliminating recurrent patellar dislocation and instability. We present the literature available on the various modifications of Elmslie-Trillat procedure and its outcome.


WGP Eardley PN Baker AG Jennings

Background: In a recent publication from the National Joint Registry it was suggested that prosthesis type influenced patient satisfaction at one year following knee arthroplasty. In this report Unicondylar Replacement (UKR) was associated with lower levels of patient satisfaction when compared to cemented TKR. The unicondylar group did however have a significantly lower Oxford Knee Score (OKS) than the TKR group and this occurred irrespective of patient age.

A common perception is that UKR is only offered to patients with lesser disease, with a decreased clinical profile. This may explain their higher levels of dissatisfaction as the overall change in their OKS from pre to post operation would be relatively smaller than for TKR.

Aim: We hypothesised that patients listed for UKR have less severe disease and therefore a lower preoperative OKS when compared to TKR.

Methods: After sample size calculation we retrospectively analysed 76 patients who underwent either UKR or TKR under the care of a single surgeon. OKS was recorded at a dedicated pre-assessment clinic. The decision to offer UKR was based on clinical and radiological criteria as outlined by the Oxford group.

Results: There were 38 patients in either group. The mean pre-operative OKS was 39.5 (26–56, SD 7.6) in the UKR group and 41.6 (31–51, SD 5.7) in the TKR group. There was no statistical difference between these two groups (p=0.18).

Discussion: Patients listed for knee replacement have significant pain and functional impairment. In our population those suitable for UKR have similarly severe symptoms to those who do not meet the criteria for UKR and are only eligible for TKR. It remains unclear why patients undergoing UKR should be less satisfied when they have better post operative patient reported outcome scores. It emphasizes the need for careful patient selection and counselling in patient undergoing UKR.


S H Zaki P J Rae

Purpose of the study: To evaluate the medium-term results of Valgus High tibial osteotomy using tomofix plate in patients with medial compartment arthritis with varus deformity.

Method: A total of 46 patients (50 knees) underwent Valgus High tibial osteotomy. The mean duration of follow-up was 60 months (36 – 72 months). The mean age was 39.5 (range 30–49) and all were male.

The patients were assessed on the basis of pre and post-operative Oxford and Knee society score, range of motion, radiological evidence of healing of the osteotomy site and alignment of the extremity.

Indication for the operation was medial compartment degeneration associated with varus malalignment.

The mean preoperative oxford knee score was 48 (range 38–54) and postoperative score was 22 (range 17–31). The knee score improved from the preoperative mean of 38 (range 30 – 55) to postoperative mean of 82 points (range 45 – 92). The mean preoperative functional score was 35 (range 25 – 55) and mean postoperative functional score was 75 points (range 50 – 95). The preoperative average knee flexion was 110 (Range 90 –130) which at the final follow-up remained unchanged. The mean preoperative Tibio-Femoral angle (mechanical) was 7 degrees varus (range 6–10) and mean postoperative Tibio-Femoral angle was 6.5 deg valgus (range 7–11).

There were no non-unions at the osteotomy site and the medial open-wedge filled-in without any need for bone graft or its substitutes

Conclusion: Our study shows that Valgus High tibial osteotomy for medial compartment arthritis using Tomofix plate gives good medium-term resutls. Longer-term follow-up is needed to establish its effectiveness in deferring joint replacement surgery.


M Odumenya M L Costa S J Krikler N Parson J Achten

Purpose of Study: To identify the functional outcome, quality of life and prosthesis survivorship in patients who have undergone the Avon patellofemoral arthroplasty at an independent centre.

Method and Results: Sixty-three patellofemoral arthroplasty (PFA) procedures were undertaken on 44 patients between May 1998 to May 2007. The primary and secondary outcome measures were knee function and quality of life, respectively. These outcomes were determined using the Oxford Knee Score (OKS) and EQ-5D and visual analogue score. Out of the forty-four patients 6 were deceased and 6 were lost to follow-up. Therefore, thirty-two patients (50 PFAs) were included; nine males and 23 females. Seventeen patients had bilateral PFA. The mean age of the patients was 65.8 years (SD 9.2). Follow-up averaged at 5.34years (range 2.1–10.2years) (SD2.64). The Oxford Knee Scores in this population showed a bimodal distribution. One group centred around 35 and the other around 60. The median Oxford knee score was 42.5 (IQR 34.25 to 54.25). Two sample t-test analysis of the population, divided as those above and below an OKS of 42, showed that follow-up time and age, did not differ between the groups (p=0.325, p=0.255 respectively). The quality of life outcome scores were significantly lower for bilateral compared to unilateral patients, with median scores of 50 and 72.5 respectively (p=0.03829). The cumulative survival at 5years for those with minimum 5 year follow-up (32 out of 50 PFA) was 100%. Three knees in total were revised. One patient developed bilateral tibiofemoral osteoarthritis, requiring revision to total knee replacement (TKA) at seven and 10 years. Another had persistent anterior knee pain and was converted to a TKA.

Conclusion: The Avon patellofemoral arthroplasty provides good functional outcome. The survivorship rate is promising although longer follow-up is required. Prudent patient selection is needed avoid high rates of revision to TKA.


Full Access
Z Abiddin K Howard CP Charalambous P Sutton R Parkinson

We report our experience with LCS Patellofemoral joint replacement. Between September 2003 and November 2007, 66 consecutive patients were reviewed retrospectively who underwent LCS patellofemoral joint replacement. There were 13 males and 51 females with a mean age of 61.6 years (range 43–78). The average follow-up was 22 months (range 11–51 months). To assess the outcome, revision for any cause was taken as the end point for this study.

A total of 14 (21.2%) revision operations were carried out at an average of 15.6 months (range 8–29 months) from the initial operation. The reasons for revision were mal-tracking of patella (3), dislocated patellar button (2), persistent unexplained pain (5) and progression of arthritis (4). Amongst the remaining 52 patients, 8 are still experiencing pain and not entirely satisfied with the procedure. 42 patients (63%) have a satisfactory outcome so far. All of them who underwent revision to a total knee replacement were satisfied with their outcome with relief in their symptoms. Revision to a total knee replacement is not a straightforward procedure, especially removing the metal backed patellar component.

The revision rate of over 21% is unacceptably high to recommend the procedure as a routine. Based on our experience, we conclude that LCS patellofemoral replacement should be used with caution.


JB Aderinto JF keating P Walmsley

Purpose: To determine the outcome following anterior tibial spine avulsion in skeletally mature patients.

Summary: The study group comprised 83 knees with anterior tibial spine avulsion. The mean age of patients at injury was 35. Twenty knees with displaced tibial spine fractures were treated with fixation of the tibial spine and 63 patients with undisplaced or minimally displaced fractures were treated non-operatively.

Twenty two percent of the non operatively managed knees developed symptomatic instability and 10% of knees treated with tibial spine fixation developed instability (p=0.22). Stiffness was more common in knees treated with tibial spine fixation than in knees managed nonoperatively (60% vs 19%, p < 0.0005). There was a tendency for increased stiffness in older patients treated with surgical fixation of the tibial spine.

Conclusion: Tibial spine fracture in skeletally mature patients is associated with significant risk of knee stiffness and instability.


S Patel F S Hossain B Paton F S Haddad

Purpose: To determine if a multi-modal programme including non-operative measures of physiotherapy and education can improve the symptoms of osteoarthritis of the knee.

Methods/Results: 72 patients with osteoarthritis of the knee confirmed on radiographic or arthroscopic evidence were referred over a 13 month period (April 2007 – May 2008) for a lower limb programme. The programme consisted of 12 classes over 6 weeks of group physiotherapy and included education on osteoarthritis, diet and exercise.

The total number of knees affected was 98. The mean number of compartments affected was 1.2 with the medial and patellofemoral compartment most affected. The mean number of classes attended was 8.3. Pre-intervention, the mean WOMAC score was 64.7 and the mean Oxford knee score was 31.9. Post-intervention at a mean follow up of 12 months (range 7 – 22 months), the mean WOMAC score was 29.4 and the mean Oxford knee score 22.4. The change in scores following intervention was statistically significant (p < 0.05). Of the cohort, 9 patients were subsequently offered or went on to have knee joint arthroplasty.

Conclusions: At 12 months, a multi-modal programme consisting of non-operative interventions has an excellent impact upon osteoarthritis of the knee with improved patient reported scores. This modality should be considered for all patients with mild to moderate osteoarthritis in whom surgical options are not otherwise indicated. Further work is required to see which components most influenced patients’ outcomes, the impact of education and group classes on maintaining physiotherapy exercises in the long term, the benefits conferred even for those patients who subsequently undergo joint arthroplasty, and whether referral to the programme from a primary care setting will lower the number of referrals of knee osteoarthritis to orthopaedic units which are ultimately managed without surgical intervention.


JP Peehal FW Smith SL Barker

Purpose: To see if the symptoms of mild to moderate degenerative knee osteoarthrosis are improved clinically by magnetic resonance therapy (MRT).

Method: This a double blind randamised control mono-centric study involving 100 volunteer patients recruited form the outpatient clinics who met the set inclusion and exclusion criteria of mild to moderate Osteoarthrosis of the knee joint. AD Elektronik GmbH, Wetzlar, Germany supplied the devices for giving MRT, which involved five sessions of one hour each on five consecutive days. These devices work with a coded chip card and only half of the 100 cards were coded to provide MRT. Base line assessment and follow up at 1 week, 1 month, 3 month and 6 months included clinical examination and Oxford and WOMAC Knee scores. Radiological assessment included baseline plain radiographs of the knee joint in standing position (AP and Lateral views) and positional MRI scan. At three months MRI scan was repeated. Data was analysed using SPSS 16.0 software and Mann-Whitney and Chi–square Tests were used.

Results: No adverse effects were reported during the study. The treatment and the placebo groups were comparable except that the male: female ratio was 1: 2. Placebo group had statistically significant improvement in the WOMAC Pain OA index at 3 months (p=0.017). There was statistically significant improvement in the range of movements at 6 months (p=0.010), but this was clinically not significant as the mean increase in Range of Movement was 4°. At the end of 6 months there was not difference between the two groups.

Conclusion: This study has found that five 1 hour sessions of MRT is a safe mode of treatment, but fails to support that it has a beneficial effect on Knee Joint Osteoathrosis.


HB Colaço S Oussedik B Paton FS Haddad

Introduction: The aim of this study is to investigate the relationship between patient psychological characteristics, adherence to rehabilitation physiotherapy and outcome at one year following anterior cruciate ligament reconstruction.

Methods: A group of 57 patients undergoing ACL reconstruction received a pre-operative psychological assessment comprising of five questionnaires; Athletic Identity Measurement Scale (AIMS), Recovery Locus of Control Scale (RLCS), Self-Motivation Inventory (SMI), Hospital Anxiety and Depression Scale (HADS), and Short Form Social Support Questionnaire (SSQ6). Four functional questionnaires were completed pre-operatively by the patient; Subjective Knee Evaluation Form (IKDC 2000), Tegner Activity Scale (TAS), Lysholm Score (LS), and Lower Extremity Functional Score (LEFS). Final outcome was assessed by repeating the functional questionnaires at 1-year post-operatively following rehabilitation. Anterior displacement of the tibia was recorded using a KT1000 arthrometer pre-operatively and at 1 year postoperatively. Adherence to rehabilitation was recorded using the Sport Injury Rehabilitation Adherence Scale (SIRAS) and attendance to physiotherapy appointments.

Results: The data were analysed using regression analysis. Self motivation, a higher athletic identity, good social support and an internal locus of control are all positive predictors of final outcome. Poor self motivation and an external locus of control are associated with less successful final outcome. Rehabilitation adherence is also a positive predictor of final outcome, although psychological factors were not found to be predictive of adherence to rehabilitation.

Discussion and Conclusion: Self motivation and an internal locus of control are positive predictors of adherence to physiotherapy and final outcome. These aspects can be reinforced during rehabilitation. Patients with an external locus of control and poor self-motivation can be identified and their pre- and post-operative management adapted to achieve optimal outcome.


N K Patel A Bucknill J Denning D Ahearne K Desai M Watson

Purpose: To determine if early MRI diagnosis in the acutely injured knee affects management, use of resources and patient satisfaction compared to conventional management with physiotherapy.

Methods: Patients referred to fracture clinic with acute knee injury in whom a specific clinical diagnosis could not be made were randomised to one of two groups. The MRI group had a scan within 2 weeks and were then reassessed in clinic with management according to the results. The control group received physiotherapy and then reassessed. Patients were assessed in clinic on presentation, at 2 weeks and then by a telephone questionnaire at 3 months. Electronic medical records were also reviewed.

Results: 48 patients were recruited in total: 23 in the MRI group (78.2% male, 21.8% female) and 25 in the control group (68% male, 32% female). The mean age was similar in the two groups (29 years (range 18–61) vs. 30 years (18–50)). The MRI group had significantly less physiotherapy appointments (5 ± 3.42 vs. 2.52 ±1.93, p=0.003) on average until definitive treatment but not outpatient appointments (2.72 ± 1.1 vs. 2.43 ±0.66, p=0.27). Median time to surgery was less in the MRI group (138 (31–199) vs.180 days (33–826) vs.) but not statistically significant (p=0.19). A similar number of patients returned to work in both groups (82.6% vs. 76%) but the MRI group had less time off work (15.82 ±22.26 vs. 20.56 ±25.38 days, p=0.48) and statistically better satisfaction scores (2 ±2.68 vs. 3.5 ±2.75, p=0.048) than the control group.

Conclusion: We have shown that early MRI in acute knee injury can provide early diagnosis of internal derangement and therefore allow targeted treatment. These patients had significantly less physiotherapy appointments and less time off work which may offset the cost of the MRI. Moreover these patients were significantly more satisfied with the service.


PJ Kempshall AN Moideen D Pemberton S Roy

Aim: To evaluate the effectiveness of all inside meniscal repair technique in treating bucket handle tears of the meniscus in the athletic population.

Method: From 2005–2008, 40 patients underwent meniscal repair for bucket handle tear of the meniscus, either as a primary procedure or combined with ACL reconstruction. All patients were contacted by clinical review, letter or telephone retrospectively. All patients were scored using the Tegner Knee score. All patients had been participating in sport at international level, semi professional level or club level. Failure was defined as a recurrence in symptoms necessitating reoperation and success as a return to competitive sport.

Results: There were 27 medial meniscal tears and 13 lateral, in 38 knees. The average age was 23 years (16–39). The average length of follow up was 1.5 years (0–2–3.1) years, and the average time from injury to surgery was 47 weeks. 9 patients were treated with fast fix (Smith and Nephew Endoscopy) and 31 Rapidloc (DePuy Mitek). There was an average of 2.85 sutures used. The overall cumulative survival rate at two years was 83.9% (4 Failures). All reoperations were preceded by a subsequent traumatic event to the knee resulting in a recurrence of symptoms. Time to return to sport in patients with associated ACL reconstruction was not affected by conincidental meniscal repair. Of the primary meniscal repairs the time to return to previous sport was less than 4 months.

Conclusion: This study shows that meniscal repair has a high success rate for sporting individuals with meniscal tears and has a high chance of the individual returning to competitive sports.


JV Banks I Pengas A Hatcher P Meyers D Sprott MJ McNicholas

This prospective case-controlled study evaluates the outcome of chronic combined anterior cruciate ligament (ACL) & posterolateral corner (PLC) knee reconstruction.

Twenty-six patients (23 male) underwent combined ACL & PLC reconstruction between October 2001 and October 2006 (Group ACL/PLC). Mean age 30.2 years (range 17–44). Mean follow-up 51 months (range 27–109). The commonest mode of injury was football. Seven patients had concomitant lateral, and 9 medial meniscal procedures, 1 osteochondral defect was micro-fractured. All procedures were performed at the same operation. Prospective scoring was done pre-operatively and 3,6,12, and 24 months post-op using Lysholm, IKDC 2000 and KOOS scoring systems. These scores were compared to an age, sex and injury matched control group of patients who also underwent ACL reconstruction without posterolateral corners injury (Group ACL).

Functional scores showed a significant improvement in all patients in both ACL/PLC and ACL groups postop (p< 0.05). Pre-op scores for Lysholm (p=0.005), IKDC (p=0.03), KOOS sports (p=0.03) and quality of life (QOL) (p=0.03) were significantly lower in Group ACL/PLC compared to Group ACL. Other significantly reduced KOOS scores were - sports 12 (p=0.04) & 24 months (p=0.004); and QOL 12 (p=0.01) & 24 months (p=0.006).

Conclusions: Injury to the posterolateral stabilizing structures of the knee usually occurs in association with other ligamentous injuries. The recognition and adequate management of this injury is crucial. Knees with combined ACL & PLC injuries have reduced function compared to ACL injuries alone. Patients undergoing combined ACL & PLC reconstruction should be made aware that the nature of their injury is such that postoperatively they may have ongoing functional limitations with respect to return to sport and quality of life.


M. Snow W.D. Stanish

Introduction: Recent data suggests that Double Bundle ACL reconstruction is bio-mechanically and potentially clinically superior. The success of Doudle bundle ACL reconstruction is dependent on tunnel placement. Of clinical concern is the increased technical difficulty and the potential for complications. The aim of our study was to determine how big the learning curve was for a high volume ACL Surgeon.

Methods: Ten Double bundle ACL reconstruction procedures were carried out on suitable individuals. Following the procedure all patients underwent a CT scan of the relevant knee. Femoral tunnel placement was measured according to the quadrant technique described by Bernard and Hertel. The ideal tunnel locations used for analysis were those described by Zantop et al. On the tibial side, the radiographic measurements were performed according to Staubli and Rauschning. The centres of the AM and PL bundles were expressed as percentages of the maximum tibial sagittal diameter. The tibial ACL attachment at the centre of the AM bundle was taken to be 30% of the maximal tibial diameter and the centre of the PL bundle was located at 44%.

The tunnel positions were measured for each patient.

Results: Good tunnel placement was achieved in the majority of patients. There was an initial learning curve with improvement in tunnel placement as experience increased. Femoral tunnel positions had the greatest variation. There were no complications. The technical challenges are discussed.

Conclusion: We have shown that it is possible for a high volume ACL surgeon to convert from a single bundle reconstruction technique to a double bundle reconstruction with relative accuracy.


S Al-Naser A P Davies

Unicompartmental knee arthroplasty remains controversial in some quarters and has been subject to recent negative press. The aim of the present study was to determine the differences in pre-operative status and early post-operative improvement between patients having unicompartmental knee Replacement (UKR) and Total Knee Replacement (TKR).

Methods: A Prospective study. Ethical approval was obtained prior to the study. Patients undergoing knee arthroplasty by two orthopaedic surgeons were included. Decision to proceed to unicompartmental or total knee replacement was at the surgeons’ discretion and was not randomised. The Oxford and the Ameri-can Knee Society scores were used to assess outcome. (Oxford score was used as a 0–48 scale; 0 being better and 48 worse). Scores were documented pre-operatively and at six weeks post-operatively.

Results: 104 patients were included in the study. 84 patients had TKR and 20 patients had UKR. Patients under going TKR had significantly worse Oxford, knee and function scores pre-operatively (32.2, 29.2 and 39.6) as compared with the UKR patients (28.5, 40.5 and 46.7) (P= 0.03, 0.001 and 0.026 respectively). TKR was associated with greater improvements in Oxford (P= 0.025), knee (P=0.0.027) and function (p=0.06) scores. However, the post operative scores were comparable; 20.4, 78.9 and 58.7 for TKR and 20.7, 80.9 and 57.9 for UKR.

Conclusions: It could perhaps be expected that patients with unicompartmental disease would have better pre-operative knee status than patients with more advanced multicompartmental disease. It is therefore understandable that patients receiving total knee replacements are able to improve more post-operatively than those receiving unicompartmental devices. Unicompartmental knees achieve only marginal initial superiority in terms of knee scores at 6 weeks follow-up. This is important and if clinical superiority and prosthesis longevity are not proven at longer term follow-up it would question the use of unicompartmental arthroplasty.


JV Banks I Pengas A Hatcher P Meyers D Sprott MJ McNicholas

The purpose of this study was to evaluate the outcome of posterior cruciate ligament (PCL) reconstruction with a double tunnel technique, using prospective pre & post-operative functional scoring and clinical evaluation.

We reviewed those patients who underwent PCL reconstruction between October 2001 and October 2006. 24 patients were identified, 23 male and 1 female. Mean age 30.1 years (range 17–43). Mean follow up 56 months (range 29–86). The commonest mode of injury was football. 3 patients had isolated PCL injuries, 21 had concomitant knee ligament injuries which were treated surgically at the same operation. Patients were prospectively scored pre-operatively and at 3, 6, 12 & 24 months post-op using the Lysholm, IKDC 2000 & KOOS scoring systems. These scores were compared to an injury matched control group who underwent comparable knee ligament reconstructions, but who had intact PCL’s.

The knee scores showed a significant improvement in all PCL reconstructed patients post-op (p< 0.05). However, significant differences were found between the PCL reconstructed and PCL intact groups. Both groups had high return to employment and return to sports rates. We describe our method of double tunnel reconstruction.

Conclusions: PCL injury is usually associated with concomitant soft tissue knee injuries. PCL deficiency contributes significantly to the morbidity of the multiple ligament injured knee. Reconstruction with the double tunnel technique described gives excellent functional improvement and high rates of return to employment and sports.


V Shanbhag S Sarasin A Robertson MC Forster

Purpose: Anterior cruciate ligament (ACL) reconstruction techniques have traditionally focused on reconstruction only of one bundle of the ACL providing good to excellent results in most cases. Biomechanical studies have shown increased anterior and rotational stability with double bundle(DB) compared to single bundle(SB) anterior cruciate ligament(ACL) reconstruction. A systematic review and meta-analysis was performed to compare double bundle and single bundle methods of anterior cruciate ligament reconstruction.

Methods and results: Medline (1966 onwards), EMBASE (1980 onwards) and the Cochrane database were searched retrieving 8465 possible articles, but only 5 studies fulfilled all the inclusion criteria. To be included, the study had to be prospective, randomised or quasi-randomised, comparing DB and SB grafts inserted using an arthroscopically assisted technique and have a minimum 18 month follow-up for all patients.

358 patients, 190 SB and 168 DB were considered for statistical analysis from these five papers. Outcome measures assessed included pivot shift testing, KT1000 arthrometer testing and IKDC knee scores. Using Review Manager 4.2 for statistical analysis; for dichotomous data, odds ratios and 95% confidence intervals were calculated and for continuous data, weighted mean difference and 95% confidence intervals were calculated.

Patients in the double bundle group were significantly less likely to have a positive pivot shift test (P< 0.0001). KT1000 arthrometer testing demonstrated greater antero-posterior stability with the DB group (P=0.002). There was no difference between the groups in terms of IKDC score.

Conclusion: The use of a double bundle technique improved both anteroposterior and rotational stability but not the clinical IKDC score suggesting that recovery of knee stability alone is not sufficient for achieving a better outcome.


A Getgood A Dickinson TPS Bhullar

Introduction: Double bundle anterior cruciate ligament (DBACL) reconstruction has been shown to improve objective measurements of rotational stability. However, subjective improvement in patient outcome has yet to be shown. The aim of this study was to investigate whether double bundle ACL reconstruction could provide satisfactory subjective and objective outcome in a consecutive patient series at a minimum of two years post operatively.

Methods: From May 2006 a consecutive group of patients underwent double bundle ACL reconstruction using doubled semitendinosus (anteromedial bundle) and gracilis (posterolateral bundle) tendons fixed with interference screws in both femur and tibia. Pre and post operative subjective and objective IKDC 2000 knee scores were collected including pivot shift and KT-1000 arthrometer assessments. A comparison was made to a cohort of single bundle ACL reconstructions performed by the same surgeon whose data was collected previously.

Results: The group included 29 patients (26 male, mean age 30; range 18–47). A significant improvement in subjective IKDC 2000 score between preop (54.8) and last follow up (76.3) was shown (p = 0.00); 96% of subjects were IKDC grade A or B; 85% of subjects had a negative pivot shift on last review with 15% eliciting a pivot glide. There were no differences in subjective or objective outcomes between the double bundle and single bundle groups.

Discussion: This data compares favourably with other published series of double bundle ACL reconstruction. Although subjective improvement in functional outcome is seen, early results do not show an improvement over single bundle reconstruction. It remains to be shown if this technique will confer an overall improvement in long term outcome via the more anatomical reconstruction.


P Baker WGP Eardley H Versey AG Jennings

All patients undergoing knee arthroplasty at our institution complete Oxford Knee Scoring (OKS) at nurse-led pre-assessment and again at an admission physiotherapy visit on the ward which may be up to 2 months later.

The aim of this study is to establish the extended reproducibility of the OKS by statistical analysis of scores taken at these intervals.

44 patients were required to achieve a 90 % probability to detect a difference at a two-sided 5 % significance level with a minimum clinical difference of 3 points, a cut off used in previous works regarding the use of OKS.

Both the overall population means and the differences between individual questions were analysed by a paired samples t test and a Wilcoxon Signed Ranks Test respectively.

Mean interval between attendance for pre-assessment and admission visit was 16 days (7–60).

A statistically significant result at the 5% level was observed for the t test t= 2.197 (44df), p= 0.03. OKS at pre-assessment was lower than at admission to the ward by 1.1 point. (−2.1 – 0.9 95% CI).

Analysis of difference between individual questions revealed only three of the pairs achieved statistical significance and in each case, the difference was less than 3 scoring units.

This study demonstrates that although there is a difference in total scoring using the OKS between two patient episodes prior to arthroplasty, a clinically relevant difference is not detected, and neither is a statistically significant difference detected when all scoring steps are analysed.

The original validation of the OKS was obtained using test-retest reproducibility over a 24 hour period. This work shows that the OKS is robust to violations in reproducibility at duration much greater than this and for practical purposes is valid if taken at any point during the pre-admission phase of care.


VB Bagaria NS Harshavardhana VR Sapre AS Chadda AM Kuthe

Purpose: There is no data concerning morphological dimensions of distal femur(DF), proximal tibia(PT) and thickness of patella(TP) in Indian population and our objective was to analyse the anthropometric data in Indian knees and to correlate them with existing knee arthroplasty systems.

Methods: MRI scans of 25 patients(15M;10F) who underwent bilateral knee scans for ligamental injuries were collected. Patients with arthritis, bone loss, varus/ valgus deformity of > 150 and those with immature skeleton were excluded. The mean age was 32 years (range 18–53y). Three surgeons independently measured medio-lateral(ML), antero-posterior(AP) lengths & aspect ratio(AR) of DF, PT and TP on three occasions one week apart to account for intra & inter-observer variability. The resultant data of 50 knees was analysed using SPSS v16.0 and compared with five different knee arthroplasty systems (PFC sigma/NexGen/Scorpio/IB-II/ Gender specific knee).

Results: The mean ML & AP for proximal tibia was 73.3±5.3 & 47.8±4.3 mm. The mean ML & AP (lateral condyle) for distal femur was 74.3±5.9 & 65.4±5.0 mm. The mean unresected thickness of patella was 24.7 & 21.8 mm in males & females respectively. The ML & AP showed a statistically significant positive correlation with person’s height (ML®=0.55;AP®=0.50 & p=0.01). A decrease in AR for increasing AP dimension was noted for both distal femur and proximal tibia (Tibia®=0.153;p=0.29 & Femur:®=−0.91;p=0.001).

Discussion: None of the prosthesis designs mimicked this decrease in AR and NexGen infact showed increase in AR.

Only Gender specific knee closely mimicked normal variation in AR and is available only for females (in India). Most of the available TKR prosthesis designs differ from true knee morphometry of Indian population. These data provides the basis for designing optimal prosthesis for people of Indian/Asian origin in UK/overseas.


NJ Bottomley EG McNally S Ostlere DJ Beard HS Gill BJL Kendrick W Jackson A Gulati DJ Simpson DW Murray CAF Dodd AJ Price

Introduction: This study explores whether modern magnetic resonance imaging (MRI) with improved cartilage sequencing is able to show a more detailed view of anteromedial osteoarthritis of the knee (AMOA). Preoperative assessment of patients and selection of intervention is very important and preoperative imaging forms an integral part of this. Modern MRI technology may allow us to visualize in great detail the structures and cartilage within the knee, providing a better understanding of the pathoanatomy of AMOA. This will be useful in preoperative assessment and surgical management of patients.

Methods: 50 patients with a radiographic diagnosis of anteromedial osteoarthritis of the knee and had been listed for unicompartmental knee arthroplasty (UKA) had MRI as part of their pre-op workup. At operation all were deemed suitable for UKA using the current Oxford indications. The image sequences were coronal, axial and sagittal with a predetermined cartilage protocol. The state of the ACL, cartilage wear location and pattern, presence of osteophytes and subchondral high signal were assessed.

Results: All the ACLs were visualized and in continuity, however 40% showed intrasubstance high signal.

100% of medial compartments showed full thickness anteromedial loss with preservation of the posteromedial cartilage. When present, the meniscus was extruded in 96% of cases.

90% of lateral compartments were normal and none had full thickness cartilage loss. However 10% showed high signal in the tibial plateau.

There was a highly reproducible pattern of osteophyte formation; 94% posteromedial and posterolateral aspect of medial femoral condyle; 90% medial tibial; 80% medial femoral and 84% lateral intercondylar notch.

Discussion: This study maps the pattern of anteromedial osteoarthritis using modern MRI techniques. This has importance in determining preoperative indications (preservation of ACL and posteromedial cartilage); surgical technique (determine pattern of osteophytes requiring resection) and potentially important for long-term outcome (early lateral compartment changes).


F Alvi C P Charalambous P Phaltankar O Gagey

Purpose: To determine whether the tendon harvester can influence harvested tendon characteristics and soft tissue disruption

Summary: We compared two harvesters with regards to the length of tendon obtained and soft tissue disruption during hamstring tendon harvesting. Thirty six semitendinosus and gracilis tendons were harvested using either a closed stripper or a blade harvester in 18 paired knees from 9 human fresh cadavers. Use of the blade harvester gave longer lengths of usable tendon (p=0.002), whilst minimising the stripping of muscle (p=0.013).

Conclusion: Our results suggest that the type of harvester per se can influence the length of tendon harvested as well as soft tissue disruption. Requesting such data from the industry prior to deciding which harvester to use seems desirable.


J E Arbuthnot R B Brink

Purpose: Anterior Cruciate Ligament (ACL) deficiency can result in symptomatic instability of the knee resulting in subsequent functional instability regardless of the patient’s age.

We reviewed a single surgeon database of 908 ACL reconstructions (ACLR’s) carried out in the last 20 years. 14 patients were identified who were 55 years or over at the time of ACLR (mean age: 60 years, range: 55–75 years). Patients were evaluated clinically and with clinical outcome scoring and KT-1000 arthrometry assessment. One patient had died but the other 13 patients were available to attend for follow-up at an average of 9.7 years post-ACLR. One patient had undergone total knee replacement. For the remainder: the most recent mean Lysholm score was 76 - improving from 35 pre-ACLR (p< 0.05); KT-1000 testing at 30 degrees flexion with 30lbs force demonstrated a side-to-side difference > 2mm in only one knee; only the same knee demonstrated a pivot shift. The most recent mean Tegner score was 3.10.

Conclusion: Anterior cruciate ligament reconstruction with autograft in the over-55 patient with minimal arthrosis is a safe procedure that returns stability to the knee and allows for return to a reasonable level of activity over the medium to long-term in the majority of cases.


A D Carrothers B Spencer Jones A Devaney R Houghton R Spencer Jones

Introduction: As knee arthroplasty is becoming more commonplace in the working population its outcome and probability of return to work is of interest. Despite a wealth of anecdotal evidence about patient return to work post knee arthroplasty there is nothing published in the recent literature. The NHS Direct patient information website quotes patients return to work about 6 to 8 weeks post knee arthroplasty. In order to address this lack of informed information we conducted a retrospective survey.

Methods: 148 consecutive patients of working age, who underwent knee arthroplasty in 2007 were identified by our Electronic Patients Record. (52 male, 96 female, average age 58 years (range 37–65 years)) They were asked to complete a simple questionnaire relating to their occupational history, arthroplasty satisfaction and their current working capacity.

Results: Our survey had a response rate of 67% (99/148 responders, 64 female and 35 male), with a range of follow up from 7 to 19 months. 39% of patients were in employment at the time of their arthroplasty, with 46 % (46/99) returning to some working capacity post surgery. 32% (32/99) patients were able to return to their exact same employment. 88% (28/32) of these patients had worked up to the date of their arthroplasty. There was no correlation between operative indication or type of prosthesis implanted and patients who returned to employment and those who did not.

Conclusion: Despite high expectation in lay literature of ability to work post knee arthroplasty, only 46% of our patients returned to any form of employment. For patients who returned to work, the duration of sick leave prior to their surgery was a strong predictor of whether they returned to any form of employment. Caution must be exercised when informing patients of likelihood of return to work post knee arthroplasty.


H Davies B Twaddle

Purpose: To examine if and when patients return to sporting activity following surgery and how their subjective assessment of ability to perform activities was affected by their injury and surgery. We also wished to examine if there was any difference in the timing of return to sport between different sporting activities and by graft (hamstring or bone, patella tendon, bone (BTB)) used for ACL reconstruction.

Method and Results: 252 ACL reconstructions were followed up for 2.5 years post surgery. Theyere evaluated pre and post surgery with Mohtadi activity scores evaluating their function for their primary and secondary sporting activities. They were also evaluated regards exactly when they got back if at all to their primary and secondary activities. 84.2% returned to activity1 at a mean of 9.3 months 87.2% returned to activity 2 at a mean of 8.5 months. 60.7% of patients who returned to activity 1 returned at the same level as prior to their injury. 69.8% of those who returned to activity 2 returned at the same level as prior to their injury. There was no significant difference in timing of return to sport between hamstring or BTB graft.

Discussion: We can conclude from this study that the mean time to return to sport following ACL reconstruction is close to what most surgeons) are telling their patients (i.e. 6 to 9 months). However there is wide variation between subjects with a number of complex factors affecting when a person returns to their activity. It is probably wrong for us to give the expectation to all patients that they will be back to their preferred activities at 6 to 9 months.


BJF Dean JJ Matthews DW Reed H Pandit E McNally N Athanasou CMLH Gibbons

The infrapatellar (Hoffa’s) fat pad can be affected by a variety of tumours and tumour-like conditions which can occasionally present a diagnostic and therapeutic challenge to the treating surgeon. The fat pad can be affected by diffuse or solitary disease. Solitary tumours are relatively uncommon but with widespread uptake of Magnetic Resonance Imaging Scans (MRI) an increasing number of Hoffa’s fat pad tumours (HFP) are being recognized.

Between 1999 and 2008, 20 patients with HFP pathology referred to Oxford bone and soft tissue tumour service underwent resection and histological examination. Clinical records, imaging and histological findings were reviewed. Histology showed eight different diagnoses with Pigmented Villonodular Synovitis (PVNS) and ganglia being the most common pathology.

In one patient, MRI identified the cause of hypophosphataemic osteomalacia as an HFP phosphaturic mesen-chyma tumour despite the lack of local symptoms.

In conclusion, the majority of solitary HFP tumours are benign and maybe cystic or solid. MRI and plain radiographs are the imaging of choice. Cystic tumours maybe aspirated but the definitive treatment of both cystic and solid tumours should be open arthrotomy and excision biopsy. Arthroscopic resection is not advised, as complete excision is not always possible. None of the 20 patients in this series had a malignant tumour but this has been reported in the literature. Calcification on plain radiographs may indicate a malignant lesion. All patients in our series reported substantial improvement in symptoms following open tumour resection.


M Cartwright-Terry A Ahmed M J McNicholas

Aim: To report outcomes of high tibial osteotomies (HTO) in the treatment of patients with symptomatic varus-osteoarthritic knees.

Methods: Fourteen patients had a medial opening wedge HTO between 2001–2008. Twelve were male, mean age 42.2 years (range 33–49). Follow-up range 8–72 (mean 31 months). Six had simultaneous ACL reconstruction (one a revision another part of multiligament reconstruction). X-rays were taken at follow-up at 6, 12, 24, 36 and 52 weeks. Patients had pre- and post-operative KOOS assessment.

Results: All patients achieved a pain free leg with radiological evidence of union at mean 4.7 months (range 3–9). Two major complications occurred in one patient (PE and sensory neuropraxia). Minor complications in three patients: cellulitis, donor site infection, 1cm limb length discrepancy. Six patients required 7 further procedures: 2 arthroscopic chondral debridements, 2 microfractures and 3 arthroplasties. Tibial knee varus angles improved from mean 4.7° to 0.28°. KOOS scores improved in all domains: pain 28.5 to 52.8 (P< 0.01), symptoms 30.4 to 48.2 (P< 0.01), ADL 31.3 to 54.4 (P< 0.05), sport and recreation 2.5 to 7.5 P=0.125 and QOL 4.69 to 17.2 (P< 0.05). Kaplan-Meier survival analysis with failure defined as conversion to TKR shows a survivorship of 78.8% at 3 years.

Conclusions: Young patients with medial compartment osteoarthritis can have improved pain and function after HTO.

Better results are reported in the literature. However, some papers suggest osteotomies have been carried out in relatively asymptomatic patients and others accept significant pain in longer follow-up intervals without their patient cohorts having been offered alternative pain relieving strategies, such as chondral resurfacing or arthroplasty.

Patients require careful counselling that they will not achieve normal function and have a high incidence of need for further intervention.


VA Currall U Butt R Greenwood S Robinson WJ Harries

Purpose: After surgeons at a regional centre for orthopaedics began to use a simplified version of multimodal analgesia protocol in total knee arthroplasty (TKA), using intra-operative periarticular infiltration of bupivacaine and epinephrine, it was decided to review which methods of anaesthesia and analgesia were being used in the unit and how effective these were in terms of postoperative analgesic requirements and patient mobility.

Methods: A retrospective casenote review was conducted of 67 consecutive patients undergoing primary TKA. Data were collected in the areas of demographics, anaesthetic analgesia, mobility and length of stay.

Results: Of 67 patients, 31 received periarticular local anaesthetic, 23 underwent femoral nerve block and 13 had neither. Patients who had the periarticular injection required significantly less morphine. In addition, length of stay was shorter and mobility was achieved sooner in these patients.

Discussion: Our technique of periarticular injection is the simplest to be described to date, using injection of bupivacaine and epinephrine alone. Unlike most previous studies, we have shown a significant improvement in postoperative mobility and a reduction in length of hospital stay, as well as confirming previous findings of a reduction in the use of opioids. This study also confirms the efficacy of bupivacaine in periarticular injections, as most previous trials have used ropivacaine, and shows that the technique is practical for use in an NHS orthopaedic unit.

Conclusion: This study has described the use of a simple technique of analgesia by periarticular injection, which has reduced the amount of opiate analgesia required postoperatively, as well as showing benefits in mobility and length of hospital stay.


I P Hamid A Williams

Purpose: Lateral meniscectomy is thought to confer a less optimal prognosis compared to medial meniscectomy however little information exists on the effect on elite sportsmen in the context of career performance and sporting ability.

Study type: Retrospective case study.

Methods: 61 international or premiership level sportsmen (36 Football, 22 Rugby, 3 Cricket) who had no previous significant knee surgery, received either medial or lateral partial meniscectomy by a single surgeon. Their subsequent career performance was analysed over a 1 to 5 year follow-up period to highlight differences in their recovery and maintenance of an elite sporting career.

Results: From our cohort 96% of sportsmen from the medial meniscectomy group were able to return to professional sports, compared to 88% in the lateral meniscectomy group. The average time to return to sports was 3.5 weeks in the medial meniscectomy group compared to 8 weeks in the lateral meniscectomy group. A statistically significant decrease in performance was noted in the lateral group, whereby 14 of the 36 sportsmen subsequently played in lower level leagues, or suffered premature retirement compared to only 1 sportsmen out of the 25 sportsmen who received a medial meniscectomy.

Conclusions: The majority of elite sportsmen who undergo partial meniscectomy are able to return to high level sporting activities and maintain their career. Unfortunately, sportsmen who undergo Lateral meniscectomy are at higher risk of not returning to their previous performance. If they do return to sport they are more likely to have diminished performance compared to those who have a medial meniscectomy. Lateral meniscectomy is associated with a relatively unpredictable recovery time-frame and higher risk of premature retirement. Athletes should be warned of these findings when treatment decisions are made.


KR Durve PR Padala M El-Shazly O Schindler

Introduction: We present preliminary short term results of medial opening wedge high tibial osteotomy with hemicallotasis using a monolateral external fixator, combined with microfracturing, in younger active patients with established Grade IV medial compartment osteoarthritis.

Methods: Prospectively collected data was analysed for 28 consecutive knees in 27 patients undergoing this procedure. Mean age was 47 years (range 28 to 64), follow up was 23 months (range 7 to 61).

Results: Mean Lysholm scores improved from 63.6 before surgery (range 42 to 85) to 81.6 at latest follow-up (range 46.5–100) (p< 0.001). Similarly, the mean Tegner activity scale improved from 1.7 (range 1 – 4) to 3.3 (range 1 – 6) (p< 0.001). Average IKDC score at last follow-up was 68 (range 35.6 – 100). Mean pain score (visual analogue scale 0 to 10) improved from 5.5 pre-operatively (range 1 – 9), to 3.5 at latest follow-up (range 0 – 8) (p< 0.001). All but 4 patients reported improved pain scores.

Superficial pin site infection occurred in 6 patients (21.4%) and settled with oral antiobiotics in all cases. One patient had persistent patellofemoral (PF) pain.

Discussion: The use of hemicallotasis for high tibial osteotomy (HTO) in association with extensive microfracturing of the medial compartment provides a viable, minimally invasive method for management of the young active patient with medial compartment osteoarthritis, without the risk of serious complications. In the short term even with advanced full thickness cartilage damage, this provides effective pain relief, helps put off more major arthroplasty alternatives and improves activity levels.


S Jones M Alnaib M Kokkinakis M Wilkinson A St Clair Gibson D Kader

The aim of this study was to evaluate the impact of a preoperative education programme on length of hospital stay for primary and revision knee arthroplasty patients.

The programme was introduced at our hospital in October 2006 to encourage patients to play an active role in their postoperative recovery process. It was delivered by a multi-disciplinary team consisting of an arthroplasty nurse, ward physiotherapist, occupational therapist and orthopaedic consultant. Patients were educated about their care pathway, knee surgery, pain management, the expected discharge goal, post operative inpatient and outpatient rehabilitation. Data was prospectively reviewed for 472 patients who underwent (primary or revision) knee arthroplasty for the period between January 2006 and November 2007. There were 150 patients in the Conventional group and 322 patients in the Educational group. The mean length of stay reduced significantly from 7 days in the Conventional group to 5 days in the Education group (P< 0.01). In addition 20 percent more patients were discharged early (within 1 to 4 days) in Education group compared to the Conventional group (P< 0.01). There was no statistically significant difference in the percentage of inpatient complications and readmissions between the two groups.

Our study demonstrates that preoperative education is a safe and effective method of reducing length of stay for knee arthroplasty patients. Significantly more patients achieved discharge within four postoperative days.


GN Hill ST O’Leary

Aim: Patient Relevant Outcome Measures are increasingly used to assess the quality of care and clinical effectiveness of surgical intervention but lack clear definitions of success or failure. We sought to evaluate and compare the ability of two outcome scores, the Lysholm and the KOOS, to determine a successful outcome following ACL reconstruction by defining discrete criteria.

Methods & Results: 204 patients underwent single bundle ACL reconstruction (four strand hamstring graft) from 2003 – 2007 and had minimum 12 months follow up. 118 (58%) patients had complete KOOS and Lysholm scores recorded pre-operatively and at 12 months post operation.

Lysholm scores at 12 months gave an average score of 90 with 82% of scores categorised “good” or “excellent” according to previously published ratings.

The 12 month KOOS were then analysed against previously published, calculated KOOS cut-off criteria for a symptomatic knee and in addition, the magnitude of change in pre- & post-op scores, as reported by the Scandinavian Ligament Registries. Applying these two patient derived definitions produced results with noticeably varied rates of success. For the most valid and sensitive KOOS subscales - Sport & Recreation and Quality of Life – the results ranged from 95% to 37%, depending on criteria selected.

Conclusions: The Lysholm Score and KOOS have to date been used primarily for comparison studies in ACL reconstruction. There has been no consensus regarding specific scores that define ‘successful outcome’ following a surgical intervention. We have shown that a patient derived KOOS could be used with a combination of absolute values and change in score to identify a successful surgical outcome.

Use of “Change in Score” represents the “Value – Added” effect of surgical intervention and demonstrates clinical effectiveness, as well as permitting comparison of individual surgeon’s performance with the standards being established by the Scandinavian Ligament Registries.


N R Howells J D Eldridge

Objective: Prospective analysis of early clinical outcome in patients treated with medial patellofemoral ligament reconstruction using an autologous semitendinosus graft plus objective arthroscopic assessment of graft tension and subsequent patella tracking.

Method: 47 consecutive patients underwent 48 procedures between September 2005 and February 2008. All procedures were performed by the senior author using a standardised technique. A semitendinosus autograft is passed extrasynovially between the isometric attachments to the patella and femur and secured with an endobutton and interference screw. The technique includes arthroscopic assessment through a superolateral portal before and after graft placement ensuring correct graft tension and patella tracking before graft fixation. Patients received pre and post operative clinical evaluation, radiological assessment, outcome scoring systems and a satisfaction questionnaire.

Results: 47 patients were followed up with mean age 26 (range 16–49) and minimum follow up of 6 months (mean 13, range 6–35). 26 were male and 22 female. Indications were atraumatic recurrent patella dislocation in 30 patients, traumatic recurrent dislocation in 15 patients, instability in 2 and anterior knee pain in 1 patient. There have been no recurrent dislocations/ subluxations, 2 have had intermittent feelings of instability 6 have complained of medial knee pain and 3 have required further surgery. Kujala Scores improved from 53 (95%CI 28–78) to 78 (95%CI 70–85) and this was statistically significant (p< 0.05). This improvement is mirrored by the other scoring systems used. 94% of patients were satisfied with their operation.

Conclusions: This technique of medial patellofemoral ligament reconstruction is the first described which allows for objective intraoperative evaluation of the required graft tension to optimise patella tracking. The early results of this technique are encouraging.


N Jacobs TPC Kane HJ Clarke

Aim: To investigate the magnitude of revenue lost by the Department of Trauma and Orthopaedics at Ports-mouth Hospitals NHS Trust in 2007 as a result of providing outpatient viscosupplementation joint injections.

Methods: Data was collated on all outpatient intra-articular hyaluronic acid viscosupplementation performed by our department in 2007. Information on existing HRG tariffs for orthopaedic outpatient attendances as well as clinical coding of joint injections by our department was also gathered.

Results: The 2007/2008 tariffs for orthopaedic outpatient first and follow-up appointments were £147 and £73 respectively for adults, and £157 and £85 respectively for children (under 17 years of age). No additional mandatory tariff currently exists for joint injections performed in the outpatient setting. During our study period, the cost of a dose of viscosuplementation (Hyaluronic acid 60mg/ 3 ml) varied between £213 and £248. A total of 812 doses of viscosupplementation were administered to outpatients by our department resulting in pharmaceutical costs of £175,126. Only 751 cases of outpatient appointment with joint injection (all types) were recorded and coded by the department.

Conclusions:

As long as no mandatory DoH tariff exists for out-patient joint injections, outpatient viscosupplementation remains an expensive service for trusts to provide and may warrant rationalisation.

Under Payment by Results it is imperative that the quality of data capture and clinical coding improve, if trusts are to maximise financial gains.

Clinicians need to be made more aware of the processes and implications of Payment by Results.

In order for trusts to receive fair remuneration it is essential that reasonable national tariffs be set for all types of procedure or service delivered.


CA Jakaraddi M Garcia-Finana T Neal A Navin JS Davidson AJA Santini

Aim: To compare the in-vitro elution characteristics of CMW1 and Palacos R bone cements containing gentamicin or teicoplanin or a combination of both.

Materials & Methods: Four types of bone cement discs (28x22mm) were prepared.

Disc 1(control) contained Palacos R or CMW1 cement without any added antibiotic.

Disc2 contained Palacos R or CMW1 with gentamicin.

Disc 3 contained Palacos R or CMW1 with teicoplanin.

Disc 4 contained Palacos R or CMW1 with gentamicin and teicoplanin powder.

The discs containing teicoplanin were prepared by adding teicoplanin powder (2gm) to the respective cement powder (40 gm with or without 0.5gm of gentamicin) and then adding the monomer (vacuum mixing).

All the discs were immersed in 50 ml normal saline bath in a sterile pot and maintained at temperature of 37 deg Celsius. 24 hours later a 5ml sample was taken from each pot for assay, to measure the amount of antibiotic eluted, using fluorescence polarization immuno-assay technique. The discs were then removed from the pots, washed with normal saline and reimmersed in a fresh 50 ml saline pot. This procedure was repeated at hours 48, 72, 120 and week 1, 2, 3 & 6 for all discs.

Results: All discs and assays were done in triplicate and average total value at 6 weeks (μ gm/ml) taken for statistical analysis.

CMW1:

Gentamicin eluted from disc4 was higher than disc2 (94.9 v 34.37. p< 0.0003).

Teicoplanin eluted from disc4 was higher than disc3 (202.1 v 147.57. p< 0.004).

PALACOS R:

Gentamicin eluted from disc4 was higher than disc2 (144.17 v 86.43. p< 0.0004).

Teicoplanin eluted from disc4 was less than disc3 (140.17 v 213.73. p< 0.008)

Conclusion: Palacos R cement elutes more antibiotic than CMW1 and antibiotic combination in bone cement resulted in, mostly, synergistic effect of increased elution of individual antibiotic.


A Kinninmonth D McDonald E Lamont H Monaghan C Lawson J Brown R Siegmeth N Scott

Purpose: We report an evolving technique for managing peri-operative pain relief that has enabled early mobilisation and facilitated early discharge after primary Total Knee Arthroplasty (TKA).

Methods and Results: Our organisation has instituted a regime covering all aspects of the peri-operative care for TKA. This includes: pre-operative counselling and preparation; multimodal anaesthesia and analgesia regime; intra-articular analgesia for 24 hours post-operation; early mobilisation regime. We carried out an audit of prospectively collected data of all patients undergoing primary TKA in the six months from January to June 2008 (total of 319 patients), including pain scores, discharge from physiotherapy and follow up data at six weeks.

A total of 305 TKAs with complete data sets were included in the analysis. Of these 36% were mobilised on the day of surgery and 93% by post-operative day 1. Catheterisation rates were 12% and the need for postoperative intra-venous fluids was 10%. In-house physiotherapy discharged 58% of patients by day 3 and 85% by day 5. The visual analogue pain scores (on movement) on day zero and day one were within acceptable limits (median = 3) and 80% of patients experienced no nausea or vomiting.

Functionally, the median range of movement at discharge was 85° with 31% of patients requiring out-patient physiotherapy assessment. At six weeks the median range of motion was 95° with only 5% of patients having a reduced range of motion (reduction of > 10°) when compared to discharge. The median Oxford scores improved from 43 pre-operatively to 26 at six weeks.

Conclusion: This regime offers an efficient method for post-operative pain relief and early mobilisation with the added benefit of reducing post-operative catheterisation, intra-venous fluid requirements and the need for post-operative physiotherapy. It compares very favourably with published data on other peri-operative regimes using regional anaesthesia.


P R Loughenbury D A MacDonald

Introduction: Tibial augments are required to replace bone loss in the proximal tibia during revision total knee replacement and can be either a rectangular ‘block’ shape or an angled ‘wedge’ shape.

Purpose of study: We have identified a high failure rate with the ‘wedge’ shape currently used in the Co-ordinate (DePuy) revision knee system.

Methods: We report a series of revision total knee replacement procedures performed using the Co-ordinate system. All revision ‘angled’ tibial wedge implants were selected from our prospective database containing follow up records for knee replacements. Patients underwent clinical and radiological review at three months following the procedure, on the anniversary of surgery and then on a yearly basis. Those with fewer than 12 months follow-up were excluded.

Results: Between December 1993 and February 2006, a total of 34 patients (19 female, 15 male) required revision knee arthroplasty with an ‘angled’ wedged tibial augment. Mean age at surgery was 59.3 years (range 46–93). Five cases were excluded due to absence of follow-up (four requiring further surgery for infection and one due to unrelated medical complications). Of the remaining 29 cases, 16 (55.2%) had no problems with the tibial implant, while 13 (44.8%) exhibited radiological changes on review. Tibial implant migration was seen in 5 cases (17.2%), all within three years of surgery. One of these has needed further revision surgery and the other four are expected to need revision in the future. Seven (24.1%) were found to have a tibial radiolucent zone, which was progressive in four cases. There was one case of stem dissociation.

Conclusion: ‘Angled’ tibial wedge implants are associated with a high rate of implant migration and loosening, presumably due to the effect of shear forces. Use of these implants should be reserved for low demand patients.


D J M Macdonald A Augustine S Farrell A Mohammed

Aim: To determine the epidemiology of total knee replacement in our hospital over two 12 month periods 5 years apart to see if patient BMI and demographics have changed.

Methods: Hospital theatre log books were examined to determine all primary total knee replacements carried out in our hospital during May 2000 – April 2001 and May 2005 – April 2006. Patient notes were examined and the following details were recorded: age, sex and BMI. Data was recorded on an excel spreadsheet.

Results: There was a significant increase in the number of patients undergoing TKR in the 2005 – 2006 time period despite no change in population served (100 vs 228, p< 0.0001). This is also a higher than expected increase in TKR surgery when compared to the national data from the arthroplasty register. There was no significant change in the age of patients undergoing TKR. There was a significant increase in the average BMI of female patients 30.2+\−5.33 vs 32 +\− 6.98 (p=0.03) but no significant difference in the BMI of males. There was also a significant increase in the number of female patients with morbid obesity (BMI> 40) 3\64 vs 19/153 p=0.047.

It would appear that there has been a significant increase in the demand for TKR over a relatively short time period and that there are approximately twice as many women needing TKR than men. Within the females there has been a significant increase in BMI and also a significant increase in those who are morbidly obese undergoing TKR. This data helps predict future demand for both primary and revision arthroplasty services in our hospital.


R Malikian K Maruthainar JA Skinner R Carrington N Maruthainar SR Cannon TWR Briggs G Dowd GW Blunn

Purpose: To determine if Cobalt-Chrome (CoCr) femoral components of knee replacement components roughen significantly, and when significant roughening may start.

Methods:

Retrieval study:

14 knee replacement components were retrieved after revision procedures. The average surface roughness (Ra) of the articulating regions of each condyle was measured by surface profilometry and compared to Ra of non-articulating regions, which acted as controls on each implant.

In vitro testing:

Pin-on-plate testing of 6 paired CoCr pins and vacuum γ-irradiated UHMWPE discs was carried out under a force of 2.3kN at 1Hz to investigate how the articular Ra of CoCr pins varied with increasing number of cycles. Ra was measured at 0, 10, 100 and 1000 cycles using surface profilometry.

Results:

Retrieval analysis:

Average medial femoral condyle Ra was significantly greater than control Ra (p=0.040). Average lateral femoral condyle Ra was not significantly greater than control Ra (p=0.158). Significantly higher average Ra was seen on the medial condyles when compared with the lateral condyles (p < 0.05). 8/14 retrieved femoral components had ≥1 significantly roughened condyle (p< 0.05).

In vitro testing:

At 100 and 1000 cycles the Ra of the CoCr pins was significantly greater than Ra at 0 cycles (p< 0.05).

Conclusion: A large proportion of femoral components of knee replacement implants roughen significantly in vivo, a finding supported by our in vitro testing which indicates that roughening may begin very early on. This may have important implications for aseptic loosening of knee replacement components. However, the average Ra of those CoCr surfaces significantly (p< 0.05) roughened was within acceptable limits for orthopaedic implants (0.050μm).


R S Kotwal J Fairclough R Morgan-Jones

Purpose of the study: We report an unusual complication of patella tendon rupture that occurred secondary to the use of static cement spacer blocks in a series of three patients undergoing staged revision total knee arthroplasty (TKA) for infection.

Methods and results: 3 male patients developed patella tendon injury secondary to anterior subluxation of static cement spacer blocks used at the first of a two-stage revision procedure for infected TKA. Average patient age was 70 years. The interval between the 1st and the 2nd stages varied between 3.5 to 24 months. At the second stage, it was observed that the patella tendon was completely severed and irreparable in one case, whereas it was partially injured and repairable in the other two cases. In the case with irreparable tendon injury, stable joint reconstruction could not be achieved at the second stage and ultimately resulted in knee arthrodesis. In the other two cases, 2nd stage revision was performed using hinged revision knee components and the tendon injury was repaired and protected with a circlage wire. None of the patients were satisfied with their outcome at the final review.

Conclusion: This is the first report in the literature reporting the complication of patella tendon rupture secondary to the use of static cement spacer blocks in staged revision knee arthroplasty. The injury can either be repairable or irreparable. The functional outcome and satisfaction is not good after the salvage procedures. Therefore, we recommend that these spacer blocks should not be used in revision knee arthroplasty.


R S Kotwal V Shanbhag M Forster A Robertson

Purpose of the study: We describe a new modified arthroscopic technique of surgically treating avulsion fractures of the tibial eminence using the Scorpion device (Arthrex, Naples, FL).

Methods and results: A 57 year-old female who sustained a type II fracture of the tibial spine was treated with arthroscopic fracture fixation using the Scorpion device to place a whip stitch into the substance of the anterior cruciate ligament (ACL). Tibial tunnels were made on the anteromedial aspect of the tibia using the Acufex ACL guide (Smith and Nephew, Mansfield, MA) and the sutures were passed through these tunnels and tied over a bony bridge. At 6 months after surgery, the patient was asymptomatic and had returned to her daily activities. She had regained full range of movement and had a clinically stable knee, confirmed on KT 2000 arthrometer. Radiographs showed anatomic reduction and fracture union.

Conclusion: The Scorpion device which is commonly used in arthroscopic shoulder surgery provides significant advantages as it can be used arthroscopically to place a whip stitch in the substance of the ACL. The hook at its end can be used to retrieve suture loop from the joint, thus reducing instrumentation and operating time. It is a user friendly arthroscopic technique that restores the necessary tension in the ACL, provides stable fracture fixation, and also results in a cosmetic end result.


D Marsland N W Bradley

We describe the use of a dental tool for the removal of excess cement during unicompartmental knee arthroplasty (UKA).

Retained excess cement following UKA is a well recognised complication. It may result in pain, impingement, loose body symptoms, vascular problems and damage to the prosthesis or structures within the lateral compartment. Symptomatic patients require additional surgery to manage such complications. The removal of excess cement becomes technically difficult during cementation of the prosthesis because there is limited surgical exposure. Consequently, the incidence of retained excess cement associated with minimally invasive knee arthroplasty ranges from 8 to 21%.

The senior author uses a ‘flat plastic’ dental instrument that is ideally shaped for use in UKA. The tool has blunt ends aligned at 90 degrees to each other which are perfectly angled to allow the rapid removal of excess cement from the femoral component and tibial tray during prosthesis insertion. It can be manoeuvred easily to break off excess bits of cement and also to retrieve them by sweeping around the prostheses from back to side. It is also used to assess alignment of the tibial tray medially and posteriorly to feel for over or under hang.

The ‘flat plastic’ dental tool helps to avoid retained excess cement and its associated complications in UKA, and is applicable in other minimally invasive arthroplasty procedures.


J H F McConway R Wilson D Molloy S O’Brien P Archbold D Beverland

Aim: To develop a flexion jig that would reliably hold the post-op knee in fixed flexion for a defined time period and determine its influence on peri-operative blood loss, transfusion, pain, and complications (specifically nerve palsy)following TKA.

Methods/Results: A previous study in this department showed immediate postoperative flexion to significantly reduce blood loss following TKR. Following this study, time in flexion was increased to 12 hours in an attempt to further reduce blood loss., some patients then developed a painful lower limb nerve palsy. This palsy was caused by pressure from the jig in the popliteal fossa/calf on nerves. The design of the jig was altered to remove pressure from these areas. Because of this design change, we were unsure whether the new jig would have the same blood saving effect, necessitating a new study.

This prospective randomised controlled trial recruited 420 patients into 3 equal groups: extension, 3 & 6 hrs flexion.

This trial found a significant reduction in blood loss(12%, p=0.006) and length of stay(1/2 day, p=0.006) in the 6 hour flexion group, compared the extension group.

There was no significant difference in pain or complication rates (excluding nerve palsy).

2 patients in the 6 hour group had postoperative nerve palsy, however, this palsy was sensory only and markedly different to that found previously. Although the palsy rate in this study is similar(1.4%) to quoted literature rates (1.3%) for TKA, it is difficult to know if the jig was the cause of palsy as the there was a difference between those caused by the old metal jig (painful) and those in this study (sensory loss only).

Conclusion: The results of this study show post-op flexion for 6 hours to significantly reduce perioperative blood loss. Palsy was reduced to match rates as quoted in the literature.


JTK Melton L Bray J Tong AJ Cossey

We performed a study to evaluate the material properties of a new cylindrical scaffold plug licensed for the treatment of osteochondral defects as prior to the removal of a core of normal femoral condylar bone, it is imperative that the biomechanical properties of replacement implant material are known.

TruFit CB plugs (Smith and Nephew) are resorbable material composed of polylactide-co-glycolide (PLG) copolymer, calcium-sulfate, polyglycolide (PGA) fibres and surfactant. The implants are 7mm, 9mm and 11mm cylindrical plugs. The stress/strain relationships of both the dual layer implant and the base layer material were examined. Compressive load testing at selected strain rates was performed in both confined and unconfined models in a substitute body fluid filled chamber.

Compressive failure was found to occur between 40–60% strain with maximum stresses at failure for the dual layer implants occurring at 5.5MPa (7mm), 5.8MPa (9mm) and at 8.5MPa (11mm). The mechanical strength under constrained loading conditions is higher than in unconstrained loading (compressive stress required to develop 5 percent strain being 0.6MPa unconfined to 1.1MPa confined for 7mm; 0.6MPa to 1.4MPa for 9mm and 1.0MPa to 3.2MPa for 11mm implants). This demonstrates the importance of a close press fit. The modulus of elasticity was calculated at 50 MPa (7mm), 60 MPa (9mm) and 80 MPa (11mm). The larger the plug size, the higher the strength shown under test conditions at all strain rates.

Prior to this study, the material properties of this implant have not been characterized. The Young’s moduli of the implants are in keeping with previous estimated values for successful regeneration of cartilage within a synthetic scaffold. The biomechanical properties described in this study will help to guide surgeons in TruFit CB use and guide the rehabilitation programmes of those patients who have had osteochondral lesions treated with TruFit CB scaffold plugs.


G S Matharu P B Pynsent

Study Objective: To determine the proportion of patients proceeding to elective total knee arthroplasty with pre-operative anaemia.

Background: Over 60,000 primary total knee replacements are performed in England and Wales each year. Blood transfusion can be associated with serious complications. A pre-operative haemoglobin of less than 12 g/dl increases the likelihood of blood transfusion in the peri-operative period by threefold [1]. Published BOA guidelines recommend patients with pre-operative haemoglobins of 12 g/dl or below in males or 11 g/dl or below in females should have their anaemia investigated and treated prior to total knee arthroplasty.

Methods: Patients having elective total knee arthroplasty at our hospital over three-months formed the study population. Data were collected on age, sex, pre- and postoperative haemoglobin, transfusion requirements in the peri-operative period, and whether the patient had inflammatory arthritis. Patients were classified according to the recommended BOA guidelines for deferring elective surgery using pre-operative haemoglobin levels. Post-operative haemoglobin drop was also calculated.

Results: Fifteen patients (7%) out of 212 had pre-operative haemoglobins below guideline thresholds. The age range of these patients was 59–84 yr. Nine patients were female. Pre-operative haemoglobin ranged from 9.2–12.0 g/dl. Post-operative haemoglobin drop ranged from 0.5–4.3 g/dl. Six patients received blood transfusion in the peri-operative period (maximum of three units). One patient had a diagnosis of inflammatory arthritis.

Discussion: Pre-operative anaemia is common in patients having elective total knee arthroplasty. In this study most anaemic patients did not have anaemias attributable to inflammatory arthritis. Using cell salvage techniques did not prevent peri-operative blood transfusion in anaemic patients.

Conclusion: Anaemic patients wanting arthroplasty in favour of surgical deferral and treatment of their anaemia must be made fully aware of the serious complications associated with blood transfusions.


M A McCleery M J Chambers W J Leach

Aims: To determine the usefulness of preoperative CRP, ESR, WCC and joint aspirate in the diagnosis of infective loosening before revision TKA.

Methods and Materials: Retrospective review of patients undergoing revision TKA for the period May 1998 to May 2008 was performed, examining the results of preoperative CRP, ESR, WCC, joint aspirate and intra-operative microbiological samples. Positive results were CRP ≥10 mg/dL, ESR ≥ 22mm/hr, WCC ≥11 g/dL and positive growth on culture unless stated as contaminant. The data was analysed to determine sensitivity, specificity, negative and positive predictive values of the tests for single stage and staged revisions.

Results: 51 patients underwent single stage revision with 10 positive cultures. CRP and WCC were highly specific for infection (84%, 98%) with low sensitivities (10%). ESR was 66% specific and 25% sensitive. All had high negative predictive values (76–86%).

23 patients underwent staged revision. 17 cases had positive cultures at 1st stage and 8 at 2nd stage. 1st stage CRP, ESR and WCC had low sensitivity (67%, 59%, 17%). WCC was 80% specific whereas CRP and ESR had low specificity (25%, 20%). All had high positive predictive value (71–80%). 2nd stage CRP and ESR were specific for infection (71%) but had low sensitivities (22 and 44%). WCC was 0% sensitive but 87% specific. Negative predictive values of CRP, ESR and WCC were 63, 71 and 62%.

For both single stage and 1st stage staged revisions, pre-operative joint aspirate was 100% specific with sensitivities of 0% for single stage and 50% in staged revisions.

Conclusion: All patients undergoing both staged and single stage revision arthroplasty should routinely have preoperative inflammatory markers and joint aspirate. However, positive intraoperative cultures may still be obtained despite negative preoperative investigations.


A Mofidi S Bajada A P Davies

The aim of this study was to document the thickness of the patellofemoral joint before and after unicompart-mental joint replacement and to correlate these data with knee outcome scores.

Seventeen patients (22 knees) who underwent Patello-femoral replacement with FPV (Wright Medical) prosthesis between 2006 and 2008 were identified retrospectively and analyzed using chart and radiological review. Oxford and AKSS knee scores were gathered prospectively pre-operative and at follow-up.

Trochlear height was measured using lateral radiograph of the knee by measuring the distance between anterior distal femoral cortex and the highest point of trochlea. Trochlear height was compared pre and postoperatively. The range of movement and the Oxford and American knee society knee scores at six weeks postoperatively were noted. Association between increased trochlear height and improved range of motion was studied.

All but two patients regained full knee extension. Postoperative mean range of flexion of the knee joint was 114 degrees. The mean Oxford knee score at 6 weeks postoperatively was 21 points. The mean American Knee Society Knee Score was 85 points and function score 60 points.

We found the average trochlear height to be 6.2 mms pre and 9.7 mms post operatively with an average increase of 3.5 mms. We found no relationship between range of motion of the knee and knee function and trochlear height. This is important because there has been concern that ‘overstuffing’ of the patellofemoral joint can lead to stiffness and failure of resolution of pain post-operatively. Rather it appears that the FPV prosthesis restores the previous anatomical thickness of this compartment.

We conclude that FPV Patello-femoral replacement results in correct anatomical reconstruction of the trochlear height. This should in turn result in durable improvements in pain and function


Neal L Millar Angela Deakin Lauren L Millar Frederic Picard

The influence of BMI on outcomes from TKA remains unclear. The purpose of this study was to evaluate if navigation affected the outcomes of TKA in obese patients.

Sixty-four (mean age 65 yrs±7) consecutive computer navigated TKA’s were compared with a matched group of 64 (65yrs±8) conventional TKA’s in patients with a BMI > 35. The groups were matched for age, gender, diagnosis and operative technique. Patients were reviewed pre-operatively and 6 weeks and 1 year post-operatively. All patients had clinical and radiological assessment and were scored using the Oxford knee score.

There were significant improvements (p< 0.001) in all clinical outcomes at 6 weeks and 1 year post-operatively in both groups. No significant differences were found between groups 6 weeks post surgery. The computer navigated group performed significantly better in post operative knee flexion (Nav 99° ± 10, Conv 94° ±12, p< 0.05) and Oxford scores (Nav 20 ± 10, Conv 25±12, p< 0.01) at 1 year compared to the conventional group. There were significantly (p< 0.05) more flexion contractures one year post-operatively in the conventional group which correlated significantly (p< 0.001) with decreased maximal knee flexion at one year.

This study suggests that navigated TKA produces better early clinical outcomes than conventional TKA in the obese patients possibly due to improved sagittal alignment as evidenced by the lack of flexion contractures 1 year post-operatively.


Neal L Millar Angela H Deakin Lauren L Millar Frederic Picard

Computer navigated total knee arthroplasty (TKA) has several proposed benefits including reduced post operative blood loss. We compared the total blood volume loss in a cohort of morbidly obese (BMI> 40) patients undergoing computer navigated (n=30) or standard intramedullary techniques (n=30) with a cohort of matched patients with a BMI< 30 also undergoing navigated (n=31) or standard TKA (n=31). Total body blood loss was calculated from body weight, height and haemotocrit change, using a model which accurately assesses true blood loss as was maximum allowable blood loss. The groups were matched for age, gender, diagnosis and operative technique.

The mean true blood volume loss was significantly (p< 0.001) less in the computer assisted group (1014±312mls) compared to the conventional group (1287±330mls). Patients with a BMI > 40 and a computer navigated procedure (1105 ±321mls) had a significantly lower (p< 0.001) blood volume loss compared to those who underwent a conventional TKA (1399±330mls). There was no significant difference in the transfusion rate or those reaching the maximum allowable blood loss between groups.

This study confirms a significant reduction in total body blood loss between computer assisted and conventional TKA in morbidly obese patients. However computer navigation did not affect the transfusion rate or those reaching the transfusion trigger in the morbidly obese group. Therefore computer navigation may reduce blood loss in the morbidly obese patient but this may not be clinically relevant to transfusion requirements as previously suggested.


Full Access
A P Monk D J Simpson S Ostlere C A F Dodd H Doll A J Price D J Beard H S Gill D W Murray C L M H Gibbons

Introduction: Patellofemoral joint subluxation is associated with pain and dysfunction. The causes of patel-lofemoral subluxation are poorly understood and multi-factorial, arising from abnormalities of both bone and soft tissues. This study aims to identify which anatomical variables assessed on Magnetic Resonance (MR) images are most relevant to patellofemoral subluxation.

Method: A retrospective analysis of MR studies of 60 patients with suspected patellofemoral subluxation was performed. All patients were graded for the severity/ magnitude of radiological subluxation using a dynamic MR scan (Grade 0 [nil] to Grade 3 [subluxed]. The patient scans were assessed using a range of anatomical variables, these included:

Patella alta,

Patella type (Wiberg classification),

Trochlea sulcus angles for bone and cartilage,

The shortest horizontal distance between the most distal part of the vastus medialis obliquis (VMO) muscle to the supra-medial aspect of the patella,

Trochlea and patella cartilage thickness (maximum depth),

The horizontal distance between the tibial tubercle and the midpoint of the femoral trochlea (TTD),

Patella Engagement – represented as the percentage of the patella height that is captured in the trochlea groove when the knee is in full extension,

A Discriminant Analysis test for multi-variant analysis was applied to establish the relationship between each bony/soft tissue anatomical variable and the severity/magnitude of patellofemoral subluxation.

Results: The distance of the VMO from the patella (p < 0.001), TTD (p < 0.001) and Patella Engagement (p < 0.001) showed highly significant relationships with patellofemoral subluxation.

Conclusions: The following three anatomical variables are associated with patellofemoral subluxation: the distance of the VMO muscle from the patella, TTD and Patella Engagement.

This is the first study to establish that patella engagement is related to PFJ subluxation showing that the lower the percentage engagement of the patella in the trochlea, the greater the severity/magnitude of patellofemoral subluxation. The finding provides greater insight into the aetiology and understanding of the mechanism of symptomatic PFJ subluxation.


R S J Nickinson C Darrah S T Donell

Aim: To determine the accuracy of clinical diagnosis in patients undergoing arthroscopic surgery of the knee.

Methods: A retrospective analysis of patients who had undergone knee arthroscopy at the Norfolk and Norwich University Hospital was performed from a prospectively gathered database. Pre-operative diagnosis was compared with operative diagnosis to determine the accuracy, sensitivity and specificity of the clinical diagnosis. The data was then analysed to determine how many patients underwent a beneficial procedure, which was defined as “a procedure from which the patient is likely to have benefited, either as a result of confirming the diagnosis or therapeutic intervention”. Finally, the results were compared with those from studies where the accuracy of MRI was assessed, to determine whether MRI is a more accurate diagnostic modality than clinical examination.

Results: The data of 698 patients was analysed. Of these 64% were male and 36% were female. The mean age at operation was 41 years (9 to 92). The overall accuracy, sensitivity and specificity of clinical diagnosis was 99%, 70% and 99% respectively. 90% of patients underwent a beneficial procedure, while 10% had a normal knee diagnosed at operation. Medial meniscal tear was the hardest pathology to diagnose, with accuracy, sensitivity and specificity rates of 82%, 92% and 79%. The results fell within the range of those found in studies, which examined the accuracy, sensitivity and specificity of MRI.

Conclusion: Our results show that clinical examination remains an accurate method of diagnosing intra-articular pathologies of the knee. Medial meniscal tear appears to be the hardest pathology to diagnose, and was the only condition with an accuracy rate under the 90th percentile. This is probably because medial tibio-femoral articular dysfunction has similar clinical findings. MRI was found to be no more effective than clinical examination at diagnosing pathologies of the knee.


E Oburu A H Deakin C Wilson

Purpose: The aim of this study was to evaluate the rate of surgical site infection (SSI) in all patients undergoing a primary total knee arthroplasty (TKA) and to audit the outcomes for those who were obese.

Methods/Results: We retrospectively reviewed data for 839 primary TKAs done at a National Arthroplasty Centre over one year (April 2007 – March 2008). BMI data was available for 824 (98%) of the patients. SSI data had been collected prospectively by the Infection Control team for up to 30 days post-operatively and was available for all patients. Patients were grouped based on their BMI and the WHO classifications (WHO Technical Report Series 894).

31.2% of the patients were obese class I (BMI 30 – 35), 19.0% were obese class II (BMI 35 – 40) and 8.6% were obese class III (BMI > 40). There were 23 patients with SSIs, 22 having superficial SSI and only one patient with a deep SSI. The overall superficial SSI rate was 2.7%. The superficial SSI rates for each group were as follows: normal (BMI < 25) = 1.3%; overweight (BMI 25 –30) = 2.3%; obese class I = 1.6%; obese class II = 3.2%; obese class III = 8.5%. The Fisher’s Exact Test between all obese patients and those with BMI < 30 showed no significant difference in superficial SSI rates (p = 0.39) but did show a significant difference between superficial SSI rates in the obese class III patients and the rest of the cohort (p = 0.008).

Conclusions: Obese class III (BMI > 40) patients are at an increase risk of superficial SSI as compared to other patients undergoing primary TKA. However, obese class I and II patients do not appear to have an increased likelihood of superficial SSI as compared to patients who have BMI < 30.


J A Pope

This study reports on the follow-up of Total Knee Arthroplasty patients in secondary care, by a physiotherapist working in an extended scope practitioner role, as a member of the orthopaedic team, and who had undertaken a negotiated work based learning module (NWBL) to develop practice skills in image interpretation at the School of Health Sciences, University of Liverpool.

Following successful completion of the NWBL by the physiotherapist an audit was undertaken of the patients seen in a total knee arthroplasty review clinic during a twelve month period. The patients were reviewed at one, three, five or seven years post-operatively on the behalf of two orthopaedic consultants specialising in total knee joint replacement (TKR). A total of 508 TKR’s were reviewed in 438 patients. Of these 37 (7%) were booked for further review by the consultants; 24 (4.7%) regarding management of their TKR, 7 (1.5%) regarding management of their contra-lateral knee and 9 (2%) regarding management of another joint. Radiographs of a further 34(6.7%) patients were discussed with the consultants (usually within a week) but did not require a review appointment by them.

The number of cases who had radiographs discussed with the consultants, but who did not require a further review appointment, suggests that the practitioner erred on the side of caution in image interpretation.

The results suggest a physiotherapist working in an extended scope practitioner role can carry out yearly follow-up of TKR patients, provided the appropriate practice skills have been developed, thereby reducing the congestion in busy follow-up clinics and allowing the surgeons to concentrate on more complex cases.

Practitioners working in such roles should be members of the orthopaedic team with regular communication with the orthopaedic surgeons.


M Ramappa I McMurtry A Port

Introduction: Periprosthetic infection with extensive bone loss is a complex situation. The appropriate management of large bone defects has not been established. Without reconstruction amputation/disarticulation is the likely outcome.

Aim: To Analyse preliminary results of direct exchange endoprosthetic reconstruction for periprosthetic knee infection associated with segmental bone defects.

Methods: Study of patients with periprosthetic knee infection and severe osteolysis treated by direct exchange tumour prostheses between June, 2005 and May, 2008 (4 - Distal femoral & 2 - Total femoral Replacements). Exclusion criteria included polymicrobial infection, resistant organisms, depressed immunity and poor peripheral perfusion. At each clinical visit they were monitored for clinical, microbiological, haematological and radiological evidence of infection. Community based antibiotic therapy was provided by specialist microbiologists. All patients were counselled and consented by the operating surgeon and specialist microbiologist prior to surgery.

Results: The mean age and follow up were 70.2 years and 30.5 months respectively. The most common infecting organism was Staphylococcus epidermidis (four), followed by Streptococcus species. Mean duration of antibiotics was 6 weeks intravenous(community based) and 8 weeks oral. 1 patient required intervention by plastic surgeons at index procedure. Radiographs showed no changes at final followup. One patient had superficial wound infection, which was successfully debrided. Knee range of movements averaged full extension to 95 degrees. The mean oxford knee scores pre and post operatively were 58 and 39.4 respectively.

Conclusion: Salvage direct exchange endoprosthetic reconstruction has provided effective pain relief, stability and improved mobility in our experience. Isolation of sensitive organism, specialist microbiologist input, availability of specialist physiotherapy and plastic surgery service, appropriate community care, good patient compliance and surgeon’s experience are key to success in these patients. Morbidity was significantly reduced due to early mobilisation.


E Reay J Wu J Holland D Deehan

We aim to explain the significant difference in survivor-ship found between two cohorts of patients who underwent different total knee replacements. The first cohort included 70 patients who underwent Kinemax Plus total knee replacement, the second cohort included 58 patients who underwent PFC Total Knee replacement. All patients were under the care of one Consultant Orthopaedic Surgeon.

Interestingly, the Kinemax Plus cohort was found to have a higher rate of revision as compared to the PFC cohort. A detailed comparison was then carried out between the two groups to identify any obvious cause for the disparity.

The two cohorts were found to be well matched with respect to age, sex, ASA grade, underlying pathology and operative technique. Median follow up being 6 years and 5 years for the Kinemax and PFC groups respectively. There were 11 failed prostheses in the kinemax cohort, 7 undergoing revision with the remaining 4 patients offered revision but unwilling have surgery. Wear of the polyethylene tibial insert was the most obvious finding at revision, present in six out of the 7 revisions. 97% of the Kinemax Plus Prostheses were intact at 5 years but by 8 years only 87% were intact.

There were no revisions performed in the PFC cohort.

Post operative x-ray analysis was undertaken to rule out prosthesis misalignment as a cause for the increased failure rate. The coronal alignment of the prostheses (CAK) was calculated and all post operative x-rays were within the normal limits of 4–10 degrees.

Analysis of the explanted Kinemax Plus polyethylene liners was undertaken. In six cases, the polyethylene bearing surfaces displayed severe surface and subsurface delamination at both medial and lateral sides. This suggests massive fatigue and fatigue wear. Only one inplant showed localised delamination. The surface characterisation suggests the hypothesis of weak UHMWPE particle interface strength.


G.A.J. Robertson S.G. Coleman J.F. Keating

Aims: The aims of this study were to define the incidence of knee stiffness following ACL reconstruction, to determine which patient factors were associated with this, and to assess how effective arthroscopic arthrolysis has been in treating the stiffness.

Methods: To define the incidence of stiffness, we reviewed the patient records of a consecutive cohort of 100 primary isolated ACL reconstructions using quadruple hamstring autografts (2004–2006). Stiffness was defined as any loss of motion as compared to the contra-lateral leg. The mean age at reconstruction was 30 years and the median delay between injury and operation was 15 months. To assess the effectiveness of arthroscopic arthrolysis, we then reviewed all the patients who had undergone this procedure following primary isolated ACL reconstruction (n=18: 1997–2008). The mean age at arthrolysis was 31 years and the median delay between reconstruction and arthrolysis was nine months.

Results: Following primary ACL reconstruction, the incidence of stiffness was 12% six months postoperatively. Poor compliance with physiotherapy (p< 0.005), previous knee surgery (p< 0.005), and anterior knee pain (p< 0.029) were significantly associated with stiffness. A binary logistic regression found both poor compliance with physiotherapy (Exp(B)=6.931; 95%CI, 1.609–29.859; p< 0.009) and previous knee surgery (Exp(B)=6.383; 95%CI, 1.548–26.322; p< 0.010) to be significant predictors of the stiffness. The rate of stiffness fell to 5% at 12 months, without operative intervention. Of the 18 patients who underwent arthroscopic arthrolysis, the mean extension loss improved from 7° to 1° and the mean flexion loss improved from 8° to 2°. Arthroscopic arthrolysis was significantly more effective in restoring extension loss (p< 0.029) if carried out within eight months of the primary reconstruction.

Conclusions: Knee stiffness remains a significant problem post ACL reconstruction. This can however be effectively improved by appropriately timed arthroscopic arthrolysis.


C Rowlands G I James A Khurana S A Jones

Objectives: To ascertain the frequency and causes of both re-admissions and re-visits (i.e. those not requiring overnight stay) to the hospital following primary and revision TKRs.

Methods: All TKRs performed between April 2007 and March 2008 were included in the study. Mean follow-up period was 9 months (range 3–15 months). Patient data was accessed via computerized patient information systems giving access to the details of inpatient admissions, A& E attendances, laboratory results, radiology reports and clinic letters. Pattern of re-hospitalisation with regards to the cause and time period post-surgery was recorded as well.

Results: Total number of primary TKRs performed in the year was 839 and the re-admission and re-visit rates were 8.22% and 4.17% respectively. The overall re-hospitalisation rate was 12.4%. Most common causes for readmission were pain/stiffness requiring MUA (1.67%) and superficial infections (1.55%). Majority of the revisits were for continuing joint pain (1.67%) and suspected DVT.

Total number of revision TKRs was 136 with a readmission and re-visit rate of 9.7% and 1.49% respectively. The total re-hospitalisation rate was 11.19%. Deep Infections were a prominent cause of readmission (4.4%).

Discussion: Around half (49.5%) of re-hospitalisations were seen in an Orthopaedic setting, the remainder presented to A& E (19.23%), Medical Assessment Units (16.35%) or General Medical Wards (7.7%). Following a primary TKR DVT/PE rates were less than 1% (0.83%). A vast majority (48.6%) of all re-admissions however, occurred within 28 days of discharge. The tradition of seeing patients for the first time in clinic postoperatively after 6–12 weeks may not be appropriate if the majority of re-admissions occur within 28 days.

Conclusion: Idiopathic joint pain and early infections are a major cause of re-hospitalisation. Re-scheduling the first follow-up appointment within the first month after a joint replacement can decrease the overall re-hospitalisation rates and also decrease the impact of these patients on other departments.


H Shahin H HD Suhani Q Lydia N Nair V Khanduja

Aim: The aim of this study was to study the course of the infra-patellar branch of the saphenous nerve (IPBSN) and describe its anatomical variations and relations.

Materials and Methods: Twenty-eight formalin-fixed cadaver lower extremity specimens were methodically dissected in the University Department of Anatomy. Dissection included identifying the saphenous nerve and tracing it distally till it pierced the deep fascia between the tendons of gracilis and sartorius. At this point, the saphenous nerve gave a branch that pierced the sartorius and became subcutaneous, known as the infrapatellar branch. The association of the nerve trunk with the sartorius muscle in terms of whether it originated above it, below it or pierced through it was studied. Following this the nerve was dissected along its course distally to the point of its termination where it gave one to three branches. The relationship of the point of termination of the IPBSN with bony surface landmarks like the medial border of the patella, the apex of the patella and the tibial tuberosity were also studied. The distance of the trunk from medial margin of patella was measured.

Conclusions: The anatomy of the IPBSN along with its branches is quite variable and a thorough knowledge of the same is essential to any knee surgeon to avoid injury to this structure.


O Shannak Z Dahabreh S Gonsalves M R Philipson S J Calder

Aim: Assessment of a new protocol, were acute soft tissue knee injuries are referred initially to a physiotherapy led knee assessment clinic.

Patients and methods: Patients reviewed in the acute knee assessment clinic (KAC) over a 6 month period were included. Patient demographics, specialist referrals, investigations, surgical interventions, and clinical outcomes were analysed.

Patients who were managed by the KAC only, were followed up for a minimum of 6 weeks and were asymptomatic at discharge.

Patients referred to a specialist were followed up prospectively in order to identify the accuracy of the initial diagnosis made in the KAC.

Results: The study included 191 patients (125 males, 66 females) with a mean age of 34.6 years.

Patients were seen in the KAC after an average 10.5 days from injury. Initial diagnoses included 35 patelo-femoral pathologies, 30 non-specific soft tissue injuries, 28 collateral ligament injuries, 27 cruciate ligament injuries, 21 combined meniscal and ligamentous injuries, 19 meniscal injuries, 17 patients with knee arthritis, 2 combined cruciate and collateral ligament injuries, 5 patellar dislocations, and 7 non-specific knee effusions.

Overall, only 52 patients (27.2%) were referred to a rheumatologist (n=6) or an orthopaedic surgeon (n=46). A total of 25 patients were referred for further investigation (Magnetic resonance imaging (MRI) n=14, Arthroscopy n=10, or both n=2). Patients who missed > 2 appointments and had no further episodes were excluded from further analysis (n=20).

The initial diagnosis correlated positively with that of the specialist in 26 out of 32 patients (81.3%) who completed a full treatment episode. The diagnosis by the physiotherapist and the specialist correlated with MRI or arthroscopy findings in 85.0% and 95.0% of cases respectively.

Conclusion: We believe that our physiotherapy led acute knee assessment clinic is effective and safe as a first referral point for acute knee injuries.


A Saithna K Dunne T Kuchenbecker P Thompson M Dhillon T Spalding

Aim: To relate clinical progress following cartilage repair using TruFit plugs with appearance on MRI imaging with a view to determining safe healing in order for patients to return to activity, without needing invasive assessment.

Methods: 26 active sporting patients underwent cartilage repair using TruFit CB plugs (Smith & Nephew) for symptomatic chondral defects in the knee between February 2006 and September 2008. The plugs are a biphasic synthetic implant designed to reform both bone and articular cartilage. As part of this prospective series patients underwent MRI at post op time-points of 6, 12, 18 and 24 months. MRI was performed using a 1.5 Tesla scanner and later using a 3T scanner. We report the results of both including T2 cartilage mapping.

Results: All 26 patients were improved at latest follow-up when compared to pre-operative scores (mean follow up 15 months (range 6–30 months)). MRI evaluation demonstrates oedema like signal surrounding the plugs at an early stage but by 6 months the oedema resolves and the subchondral lamina is seen to reform. By 12 months the bone part of the plug has similar appearance to host bone and the neo-cartilage shows similar signal to native cartilage on all MRI modalities (1.5T, 3T and T2 mapping). This suggests that the repair tissue contains a high percentage of hyaline like cartilage. In one patient slow clinical improvement was reflected in the MRI appearance.

Conclusion: MRI imaging appears to relate to clinical improvement according to KOOS, IKDC, Lysholm, Tegner and SF36 scores. This indicates that MRI is a useful imaging tool for assessing healing, and knowledge of the recovery pattern is important for quantifying healing and for better advising patients on when it may be safe to load repaired areas.


A Saithna J Arbuthnot B Almazedi T Spalding

Purpose: To investigate the validity of previous observations that meniscal repair has a better success rate when associated with ACL reconstruction.

Methods and Results: The case notes of 170 patients who underwent meniscal repair between May 1999 and May 2007 were analysed for causes of re-operation and relation to status of the ACL. Mean age at the time of surgery was 28 years.

41 patients underwent re-operation at a mean time interval of 21 months (range 2 weeks - 87 months). 79 patients (Group A) had isolated meniscal tears. 44 patients (Group B) had meniscal repair at the same time as elective ACL reconstruction and underwent brace-free, accelerated rehabilitation. 47 patients (Group C) had meniscal repair in association with ACL disruption and underwent staged ligament reconstruction.

In Group A, 23 patients underwent re-operation (Indications; meniscal symptoms 21, stiffness 1, infection 1). Nineteen repairs (23.8%) were found to have failed. In Group B, 15 patients underwent re-operation (Indications; meniscal symptoms 12, stiffness 1, revision ACL 2). Twelve (27.2%) repairs were found to have failed. In Group C, Nine (19.6%) repairs were found to have failed. 6 at the time of staged ACL reconstruction and 3 subsequently, at further arthroscopy. There was no statistical difference between the groups with respect to the incidence of failed meniscal repairs.

Analysis of possible predictive factors including age, gender, location of lesion and the type of repair did not show statistical significance.

Conclusions: Reoperation rate following meniscal repair is high. Meniscal repair for tears associated with ACL disruption in this group did not appear to have a higher success rate compared to isolated tears. This raises questions regarding the current practice of ignoring meniscal repair and instituting brace-free, early, aggressive rehabilitation following concomitant ACL reconstruction.


H Toumi TM Best MC Forster J Fairclough

Purpose: A relationship between vastus medialis oblique (VMO) strength and anterior pain and disability has been suggested. A biomechanical protocol was used to access the deficiency of the quadriceps muscles in patients with anterior knee pain.

Methods and Results: A biomechanical evaluation was conducted on 54 patients with anterior knee pain (34 females and 20 males). All patient x-rays were normal through interpretation by a blinded radiologist. A Kistler force plate, a VICON motion analysis system and surface electromyography were used to quantify biomechanical function during isometric, walking and squatting exercises.

For 42 of the 54 (78%) subjects, during isometric and walking exercises we observed that activation of the VMO, rectus femoris (RF) and vastus lateralis (VL) muscles of the symptomatic leg was not significantly different from those of the asymptomatic leg (p< 0.01). However, for 31 patients (57%) during the eccentric phase of the squat exercises, the symptomatic leg presented with high activation of VL compared to VMO and RF (p< 0.01). During the concentric phase, 45 patients (83%) presented with higher activation of the VL compared to the VMO.

Conclusion: VMO activity during squatting for the symptomatic patient with anterior knee pain leg differs fundamentally during walking and isometric exercise compared to squatting tasks. Moreover, the relative contribution of the VL compared to the VMO during the eccentric phase of the squat exercises was different to those recorded during the concentric phase. Therefore, we suggest that maximal isometric and or isokinetic exercises are not sufficient to access the quadriceps function in relation to anterior knee pain. A thorough biomechanical assessment, including functional testing to reproduce the patient’s pain and locate the nature of the symptoms is suggested.


A Vasireddy B Navadgi S Deo V Satish IMR Lowdon

Purpose of study: With the increasing demand for arthroplasty surgery, it is important to maintain a high quality of care. We describe a clinical governance framework for a simple, easy to implement method of assessing and monitoring radiological outcome following total knee arthroplasty.

Methods: We completed a two-year prospective study (January 2006 to December 2007 inclusive) of all total knee arthroplasty operations. This included 1,295 procedures, the majority of which were undertaken by two Consultant Surgeons and up to eight independent middle grade surgeons. The two Consultant Knee Surgeons assessed component position on standard post-operative weight-bearing antero-posterior and lateral knee radiographs on a weekly basis. They were blinded to both the patient and surgeon details, and used our own simple grading system, whose weighted Kappa variance showed ‘moderate’ interobserver (K = 0.41) and intraobserver reliability (K = 0.51). Our system comprised of only three ordinal scores, which were good (score of 1), acceptable (score of 2) and poor (score of 3).

Results: We provided individual surgeons with their results on a six-monthly basis. The average score for all the surgeons was good. The scores of the independent middle-grade surgeons were analysed by the Consultants, and feedback was provided in the form of formal advice and supervised surgical sessions. Repeat proportional analysis of their radiological scores showed significant improvements for all the individual surgeons (Pearson-Chi Square p value < 0.05).

Conclusions: Clinical governance is an important facet of excellence in medical practice. Our system allows continued prospective assessment of radiological outcome following total knee arthroplasty. By utilising such systems and ensuring an atmosphere of clinical excellence, we are able to employ more surgeons and undertake an increased workload, whilst maintaining high standards. This assessment tool can also be used to assess and appraise trainees during their progression.


C Ward A Hayward DJ Deehan R Aspden AG Sutherland

Surgical reconstruction of the injured Anterior Cruciate Ligament (ACL) is an effective solution to knee instability, but not all grafts incorporate well. The biological environment in the knee that controls graft integration is not well understood, and this study aims to fill that gap as the first step towards a translational approach to optimise outcomes.

Over two stages, tissue samples and knee fluid samples were harvested from patients undergoing ACL reconstruction. These samples were cultured and stored to allow batch analysis for a variety of cytokines, growth factors and collagenases.

Stage 1 (n=14) identified the presence of specific pro-inflammatory cytokines, growth factors and latent collagenase. Information gathered allowed a more targeted approach to be used in stage 2 (n=18). Stage 2 data from tissue cultures suggest that collagenase activity peaks later than 6 hours post-op. The relationships between collagenase activity and levels of TNF-alpha, IL-1beta and bFGF are of potential interest, and the profiles of patients will be compared with longer term follow-up data to determine any effects on outcomes.

Further detailed assessment of the biology of ACL graft incorporation is required, but these preliminary data have clarified some of the details worthy of further study.


R W Trickett C Wilson

We describe a new method for reconstructing the patellar tendon following combined injury to the patellar tendon and anterior cruciate ligament (ACL).

Combined injuries to the patellar tendon and the ACL represent a rare and potentially serious injury pattern. The injury to the patellar tendon can often go undiagnosed at primary presentation. Reconstructive options for the patellar tendon are described but can be technically difficult, particularly if ipsilateral hamstring has been used for anterior cruciate ligament reconstruction. Evidence suggests combined injuries generally lead to poor long term outcome.

We describe a case of a 26 year old male who presented with a reconstructed ACL and a patellar tendon deficient knee. Diagnosis was confirmed on Magnetic Resonance Imaging (MRI). Ipsilateral hamstrings had been used as donor for ACL reconstruction. An Achilles tendon allograft with distal bone block was used in combination with contralateral semitendinosus and gracilis autograft to reconstruct the three bundles of the patellar tendon. The patient experienced no postoperative complications and was followed up radiologically and clinically. Computer Topography imaging performed at 6 months post-operatively showed union of the bony Achilles tendon block. MRI performed 1 year post-operatively showed good incorporation of the tendinous grafts and no evidence of degeneration or tearing. Oxford knee score at 6 months post-operatively was 31/48. One year post-operatively full pre-injury activity level had been achieved.

We believe this method to provide adequate strength and integrity, enabling early rehabilitation following this rare injury. It has also been shown to give a good functional outcome.


ML van der Linden PA Roche PJ Rowe RW Nutton

The aim of this study was to investigate the pre-operative factors predicting the knee range of motion during stair ascending and descending a year after total knee arthroplasty.

The pre-operative and one year post-operative results of fifty six patients with osteoarthritis were analysed. Range of knee motion during stair ascent and descent was recorded using electrogoniometry. Pre-operative measures were grouped in three different domains; the Demographic Domain with age and Body Mass Index (BMI), the Body Function Domain with knee range of motion in long sitting (ROMsit), Knee extensor moment, Pain on a Visual Analogue Scale and the stiffness component of the Western Ontario McMaster University Osteoarthritis Index (WOMAC) and thirdly the Psychosocial Domain with the Tampa scale for ‘fear of movement’ (TSK) and the sense of helplessness due to pain. Hierarchical Multiple Regression was used to analyse the relative importance of measures grouped into the three domain blocks on range of motion of the operated knee during stair ascent and descent. Model 1 contained domain block 1, model 2 included domain blocks 1 and 2 and model 3 included domain blocks 1,2 and 3.

Learned helplessness was a significant predicting factor for stair descent (beta; −0.538, p=0.025) while for stair ascent, age (beta 0.375, p=0.005) and ROMsit (beta 0.365, p=0.021) were significant predicting variables.

These results show that postoperative stair ascent and descent are predicted by different pre-operative factors. For stair ascent the demographic factors age and function factor ROM are important, while for stair descent, only the addition of the psychosocial factors in model 3 resulted in a significant change. These results indicate that treatment of patients with end-stage osteoarthritis should not only be aimed at improving range of motion of the knee but should also take into account psychosocial variables such as a sense of helplessness due to pain.


S Srinivas F Cacciola I E Collins S M H Mehdian

Purpose: To determine frequency of reoperations after definitive spinal fusion in patients with AIS and identify factors responsible

Methods and results: We undertook a retrospective review of surgical logs of patients with AIS who underwent surgical fixation during 1994–2004 and detailed case notes review of patients who required > 1 operation after definitive fusion. Results were compared according to approach used during primary operation.

We reviewed surgical logs of 310 patients who underwent instrumented spinal fusion for AIS. Approach at primary operation was anterior 101, posterior 109 and combined 100. Of these, 33 patients underwent 58 reoperations (10.6 %) after definitive fusion. Median age was 14.7 years; median follow up 5.4 years. Amongst these, primary operation was Anterior in 5 patients (7 reoperations, 5%), Posterior 13 patients (25 re-ops, 11.9%) and Combined 15 patients (26 re-ops, 15%). 12 patients required more than 1 reoperation.

Common indications were infection (9), failure of fixation either due to curve progression (10), junctional kyphosis (7) or pseudoarthrosis (3). 16 revisions were undertaken due to implant related symptoms. 5 patients with posterior instrumentation requested removal of implant. Only 1 patient had a neurological deficit that required removal of implant. 13 patients required secondary costoplasty.

Discussion: Risk of reoperation after definitive fusion in AIS is 10.6 % in our institution. Reoperation rates were maximal with combined approach and least with anterior approach (15% v 5%). Common indication with posterior instrumentation was implant related and in anterior surgery due to curve progression (wrong level fixation).

Ethics approval: Audit/service standard in trust number: 1236

Interest Statement: None


JA Short LM Breakwell AA Cole

Purpose: To ascertain whether the methods of prone positioning we use have any influence on the incidence of perioperative critical incidents and development of postoperative liver dysfunction in our scoliosis patients.

Methods: A retrospective review of 72 patients undergoing posterior correction and fusion for scoliosis from August 2006 to November 2007. Details were recorded from anaesthetic charts, operation notes, blood results and cell salvage data.

Results: Patients ranged in age from 2 to 24 years. The methods of prone positioning were Transverse Bolsters (23), Allen Frame 4-point support (25), Lateral Bolsters (11) and the Knight Table (13). Perioperative haemodynamic instability was noted in 8% of patients on the Allen Frame, 43% on transverse bolsters, 15% on the Knight Table and 55% on lateral bolsters. Two cardiac arrests, one fatal and one with good recovery, both occurred on transverse bolsters. Of 22 other complications attributable to mechanical effects of prone positioning, 16 occurred on transverse bolsters, 4 on the Allen Frame, 1 on lateral bolsters and 1 on the Knight Table. 34% of patients had liver dysfunction postoperatively. None had been positioned on the Knight Table or lateral bolsters. There was no significant difference between the incidence of liver dysfunction associated with the Allen Frame or transverse bolsters.

Conclusion: Transverse bolsters are associated with a high number of critical incidents and should be avoided if possible.

Ethics approval – not required

Interest Statement - none


PR Loughenbury BT Brooke AC Gardner L Berry AS Rao RA Dunsmuir PA Millner

Purpose of the study: To investigate whether autologous blood transfusion (ABT) drains and peri-operative cell salvage reduce allogeneic transfusion requirements for scoliosis surgery in our unit.

Methods: Prospective data collection on transfusion requirements of patients undergoing scoliosis surgery between January 2006 and February 2008. Cases were split into three groups, representing recent stepwise changes in transfusion practice. Group A received ‘traditional treatment’ of allogeneic red cell transfusion (ARCT) in response to intra- or post-operative anaemia (Hb< 8g/dL or symptomatic anaemia). Group B received peri-operative cell salvage in addition to ‘traditional treatment’. In group C, ABT wound drains were used alongside peri-operative cell salvage and ‘traditional treatment’.

Results: ARCT was required for 23 of the 35 procedures (66%) in group A, 22 of 37 (59%) in group B and 10 of 20 (50%) in group C. Where patients required ARCT, those in group C received fewer units (mean 2.6) than group B (mean 3.1) and group A (mean 3.7). There was no difference in mean preoperative haemoglobin levels (A – 13.56g/dL SD 1.36; B – 13.35g/dL SD 1.46; C – 13.94g/dL SD 1.25). Mean length of inpatient stay was lowest in group C (9.11 days), and lower in group B (12.02) than group A (13.75).

Conclusion: Use of ABT drains and peri-operative cell salvage lead to reduced allogeneic transfusion needs for scoliosis surgery in our unit. Lowest transfusion rates were seen when both were used together, leading to a 16% reduction in the need for ARCT.

Ethics approval: None

Interest Statement: None


E H Seel K Wainwright E M Davies

Purpose of study: Evaluate our surgical site infection (SSI) rate in scoliosis surgery against nationally agreed standards, examine local practices to limit SSI and compare metalwork survivorship in the presence of infection.

Methods and Results : Retrospective analysis of patients undergoing instrumented correction of scoliosis with or without fusion between September 2003 and January 2009. Clinical and laboratory records of 134 patients (age range 10 months to 22 years) were examined for any evidence of SSI. There were 14 (10.4%) SSI cases, of which 8 (5.9%) were clinically significant deep SSIs, which is slightly higher than a pooled SSI rate of 2.2% from a meta-analysis of infection in spinal surgery (range 1.2 to 8.5%)1. Half of our deep SSIs occurred in neuromuscular scoliosis corrections with the most prevalent pathogen being E. Coli (28%) overall. All deep SSI patients underwent surgical debridement and iv antibiotics and we were able to retain the metalwork in all early (within 21 days) SSIs (6 of 8) but in neither late SSI (588 and 814 days). No single common variable was identified from our data-set as a risk factor for SSI although high staff numbers in theatre was noted. Infection rate increased toward the end of our series which coincided with a change in antibiotic prophylaxis protocol and paradoxically with a move to a laminar flow theatre.

Conclusion : Our SSI rate in scoliosis surgery was not significantly higher than previously published pooled rates. No single common variable was identified as risk factor for SSI. An empirical return to previous antibiotic prophylaxis could be recommended along with limiting staff numbers and movements within the operating theatre.

Ethics approval: Audit/service standard in trust

Conflict of Interest Statement: None


BEWARE OF SRS PRESENTATIONS Pages 426 - 426
Full Access
R Mehdian JL Nutt NS Harshavardhana SMH Mehdian

Purpose: To determine presentation to publication conversion rate(PPCR) in peer-reviewed indexed journals of abstracts presented at SRS annual meetings and to evaluate for consistency between abstracts and subsequently published full-text articles(FTA).

Methods: We reviewed all presentations (podium & posters) of past SRS annual meeting proceedings(2000–04) and undertook a comprehensive PubMed search to determine if the abstract was followed by a publication subsequent to its presentation as FTA up to Dec 2008. The published FTA was compared with original abstract(OAb) and evaluated for consistency with respect to study cohort/design, conclusion and authorship against a structured proforma.

Results: 1063 abstracts(452 podium;611 posters) were identified. 560 (295 podium;265 posters) were published as FTA in 51 journals. The overall PPCR was 52.68%(65.26 for podium;43.37% for posters). Two-thirds of them were published in Spine (361 FTA). 87.32% of them were published within 3 years of presentation(489/560). Interestingly 16 presentations were already published as FTA before their sub-mission(2.85%). The PPCR was 1.5 times higher for free-papers as compared to posters and was statistically significant (p< 0.0001) and OR 2.45(1.90–3.15).

Conclusion: The PPCR of SRS presentations is better than AAOS(34.2%;Bhandari et al, JBJS(Am)2002:84(4),615–21) and stands high in comparison to other medical specialties (32–72%). Though the studies were of high quality/content, changes to the cohort, authors or/& conclusion was common (seen in two-thirds of FTA). The acceptance of an abstract for podium presentation at SRS annual meeting is a benchmark of quality. However they (esp. posters) should be interpreted with caution until their subsequent publication as a FTA.

Ethics approval: Not applicable

Interest Statement: None (No grants obtained from any agency).


N. Suzuki K. Kono

Purpose: To introduce our new surgical technique for better correction of scoliosis and rib hump deformity.

Surgical technique: The technique consists of rib mobilization (RM) and hook rotation maneuver (HRM). RM is to release costo-vertebral connection bilaterally from T5 to T10 to mobilize ribs obtaining more flexibility of the spine. HRM is to rotate convex side hooks on transverse process ventrally pushing down the ribs, thus giving derotational force while compression force is applied.

Subjects: Forty-six idiopathic cases with minimum 1 year follow-up were reviewed. The average F-up period is 15.1m( 12 – 24). The average age at surgery was 20.1 y(12–57). Conventional multiple hooks, screws, wires and rod system was used. Results: The average Cobb angle was 56.0 ( 40 – 93) degrees. The average rib hump was 22.5 mm in height and 13.9 degrees by scoliometer. At 3 w post-op, 6 m post-op, and at F-up, the average Cobb angle was 13.0 (77.9%), 15.6 (73.4%), and 16.0 (72.6%, 43 – 100%)) respectively. The average rib hump at 6m post-op and at F-up was 9.7 mm in height and 6.8 degrees, and 10.3mm and 6.4 degrees respectively. The hump index at thoracic level was 5.49 pre-op, 3.73 at 6m and 4.25 at F-up.

Conclusion: Our new technique improved the correction of not only scoliosis but also thoracic hump significantly. The derotational force by HRM is weaker than direct derotation by pedicle screw. However, it is undoubtedly a safer and less expensive technique than thoracic pedicle screw, providing significant correction of rib hump.


S. Valanejad E.B. Ahmed V. Jasani P. Heath

Purpose of Study: To observe the efficiency of the combined motor-somatosensory monitoring and somatosensory-alone monitoring to identify the intra-operative neurologic changes.

Methods and Results: We retrospectively assessed 123 cases in our centre, who had complete neurophysiological report while undergoing corrective spinal deformity surgery with spinal monitoring, from 2004 to 2008. Combined motor-somatosensory, somatosensory-alone and motor-alone monitoring were applied in sixty five, fifty and eight operations, respectively. We also looked at the factors that could potentially affect the neuro-physiologic monitoring, such as preoperative neurological status, anaesthetic method, blood loss, competency level of the monitoring team and the reaction of the surgical team to a significant monitoring event. In total, there were only two cases of true positive event, defined as a significant intraoperative event and postoperative neurological deficit. Both of these cases had combined monitoring during their procedures. No case of false negative was observed. There were also five cases with a significant intraoperative event without post operative neurologic sequel (false positive). Four of these had combined monitoring, with complete normal sensory monitoring and abnormal motor monitoring, which prompted the operating team to the appropriate action.

Conclusion: Based on this observation, it is felt that the combined monitoring during spinal deformity correction procedures is superior to the sensory-alone monitoring for identifying the impending neurologic deficits. This is in accordance with the previous reports and recommendations.


A A Irwin A L Khan D Fender P L Sanderson M J Gibson

Background: Selective lumbar nerve root blocks (SLNRB) are widely used as a diagnostic tool. The usefulness of this technique depends on the ability to accurately infiltrate the desired nerve root without blocking the traversing nerve root to the next level. The aim of this retrospective study was to ascertain the accuracy of SLNRB’s in adult deformity.

Method: 30 SLNRB’s were performed by one surgeon on patients with adult deformity.Pre-operative AP + lateral lumbar films were used to quantify the degree of deformity using the Schwab grading system. An AP fluoroscopic film was taken and analysed to determine the flow of injectate in relation to pedicle anatomy. The results were analysed to determine the accuracy of SLN-RB’s in adult deformity.

Results: Of the 30 patients with deformity 17 needle tips were positioned lateral to the middle third of the pedicle and 13 under the middle third of the pedicle. Of the 17 needle tips placed laterally 8 (47%) had flow into the nerve root sheath, 6 (35%) into the nerve root sheath + canal and 3 (17%) into the canal alone. Overall accuracy with no epidural spread was 40% compared the published standard of 61%.

Conclusions: The accuracy of SLNRB in adult deformity was significantly less than the published standard in patients without deformity. In addition the accuracy of SLNRB with needle tip position lateral to the pedicle was only 47% compared to 96% in previous studies. The suggestion of this author is that contrast is used in all SLNRB’s in patients with deformity in order to allow accurate clinical interpretation of results.


Full Access
S Srinivas R Shetty F Cacciola I E Collins S M H Mehdian

Purpose: To determine the incidence and outcome of late costoplasty in surgical management of IdS.

Methods and results: A retrospective review of prospectively collected data on patients with IdS who underwent costoplasty after definitive fusion during a 10 year period (1994–2004).

We reviewed surgical records of 318 patients who underwent instrumented spinal fusion for IdS at our centre. Amongst these, 15 patients had undergone late costoplasty. Pre-operative assessment included rib hump measurement, photographs and plain radiographs. 4 patients had computerised tomography to evaluate deformity. Outcome measures included patient satisfaction and clinical evaluation.

Results [Mean (SD)]: Age at primary operation was 12.3(3.3) years; age at costoplasty 17.1(2.7) years. Pre-operative Cobb angle was 64.1 (19.5) and postoperative Cobb 36.9 (15.7) degrees. Median time between primary operation and costoplasty was 4 years. Median follow up was 7 years. Indication for costoplasty was cosmetic deformity with prominent rib hump (n=9) and curve progression (n=6). Approach at primary operation was anterior 1 case, posterior 3 and combined 9 cases. Median length of stay was 5 days.

All patients except 1 had significant reduction in rib hump deformity. Complications included 1 case of surgical scar tenderness, 1 transient neuralgia and 1 patient required a chest drain due to haemothorax.

Discussion: Costoplasty is a cosmetic procedure for the correction of rib prominence in scoliosis. There is low incidence of late costoplasty (i.e. after definitive spinal fusion) in IdS. Following costoplasty, patients were satisfied with their cosmetic appearance; no major complications occurred and no further reoperation was needed.

Ethics approval: Audit/service standard in trust number: 1236

Interest Statement: None


W Bertram R Ahmad N Orpen T Barton I Nelson J Hutchinson

The main objective of our review was to access the inter-net websites providing information on non operative treatment of scoliosis and to assess the evidence for each treatment in the medical literature.

Methods: We identified top five search engines at the site www.searchengines.com. The search term “scoliosis treatment” was entered into each search engine. The websites were reviewed and each search engine produced from 145,354 to 5460,000 results. We identified twenty non operative treatments for scoliosis. We further evaluated and studied these non operative treatments by using each treatment as a search term. The accuracy of these treatments was checked by doing a medical literature review. We used Medline 1950 to November 2008 and Embase 1980 to November 2008.

Results: 260 websites were duplicated in the five search engines, 103 websites only mentioned surgical treatment of scoliosis, and 10 websites could not be accessed at the time of the study. We evaluated the remaining 127 websites using the key words “scoliosis treatment” to generate a list of twenty unique non operative scoliosis treatments. These treatments when entered individually into the search engines enabled us to produce a list of these treatments in decreasing order of frequency. This was based on the number of results that each treatment generated.

These treatments were then entered for search in Medline and Embase, only 45% (9/20) of these treatments were found to have been described in the medical literature.

Conclusion: Our study did reveal that information on non operative treatment of scoliosis leaves much to be desired. Based on this study we recommend that it is the duty of the treating surgeon to warn the patients of the potential danger of misinformation that is abundant on the internet.

Ethics approval: None

Interest Statement: None


I Siddique R Sacho NJ Oxborrow JE Wraith JB Williamson

Aim: This study presents analysis of the largest case series to date in the published literature of patients with Hurler Syndrome, to identify the severity of thoraco-lumbar kyphosis, risk factors for progression and results of intervention.

Methods and Results: Forty two patients with MPS-I had treatment with Bone-marrow transplantation and/ or enzyme replacement therapy between June 1995 and October 2007. These patients had regular systematic clinical review and were seen at least annually. Standing lateral radiographs of the thoracolumbar spine were retrieved and analysed.

At initial examination (average age 1y 1m) the thoracolumbar kyphosis measured a mean of 39.6 degrees (SD 12 degrees). Analysis of non-operatively treated patients revealed that patients with an initial kyphosis angle (average age 1y 2m) of less than 40 degrees were significantly less likely to develop progressive kyphosis over the average follow-up period of 3.5 years (mean initial angle 30 degrees and at final follow-up 34 degrees) than those with an angle greater than 40 degrees (mean angle initially 46 degrees and at final follow-up 61 degrees), p=0.005 (repeated measures ANOVA). Seven patients underwent surgical intervention at mean age of 3 years for progressive deformity with favourable results.

Conclusion: Thoracolumbar kyphosis is of variable severity in Hurler’s syndrome and patient’s who present with a kyphosis angle of greater than forty degrees on initial radiographic examination are significantly more likely to develop progressive kyphosis.

Ethics approval: None

Interest Statement: None


S. Mukhopadhyay S Batra S Kamath S Ahuja

Incidence of pars defect associated with idiopathic scoliosis has been reported as 6% based on roentgenographic evaluation in previous studies. (Fisk et al, 1978). We aim to present our results in an MRI based study.

Methods: 229 patients of adolescent idiopathic scoliosis (AIS) who had an MRI scan over a period of three years (2006–2008), performed either as a preoperative investigation or due to other symptoms were reviewed. All MRI scans were reviewed by two experienced musculoskeletal radiology consultants independently.

Result

Among 229 patients 18 (7.86%) patients were found to have pars defect. Mean age-group of patients were (19 years, range-11–40). Male-5 (26.3%), female- 4(73.6%). Majority of the patients with were females (72.2%). There was varying severity of curve patterns, major thoracic curve-10, major lumbar curve-4, mild thoracic curve-3 and mild lumbar curve in one. Bilateral pars defect was noted in 14 (77.7%) patients.

Discussion

Previous studies (Fisk et al, 1978; Mau H 1977) have described the incidence of pars defect as approximately 6.2%. Recent studies have emphasized use of MRI to diagnose pars defect based on signal changes in the pedicle (Jon R. Davids et al, 2004). Our study reveals the incidence of pars defect in AIS to be 7.86 % based on MRI diagnosis which does not seem to be different to previous roentgenographic studies.


R.E. Foulkes S. James A. Jones J. Howes P.R. Davies S Ahuja

Background: It remains unclear and controversial whether preoperative magnetic resonance imaging (MRI) in patients with adolescent idiopathic scoliosis (AIS) should be mandatory.

Aim: (1) To review our own practice, (2) conduct a national survey of United Kingdom Consultants, and (3) to perform a literature review.

Methods: Our own practice was established by identifying patients with AIS and examining whether an MRI scan was performed preoperatively. A survey of Consultants practice in the UK (British Scoliosis Members) was conducted by either an e-mail or telephone conversation. Finally, a literature survey was performed to establish current views.

Results: 118 patients with AIS were identified between 2003 and 2007. 78% of these patients underwent pre-operative MRI scans. Neural axis abnormalities were found in 8% of these patients. They included syrinx’s, chiari malformations, tonsillar herniation, cord tethering, central canal dilatation and undiagnosed spina bifida. Only 1 patient required intervention by the neurosurgeons. 92% of respondents to the national survey routinely performed preoperative MRI scans. The literature was not conclusive with regards to mandatory preoperative imaging.

Conclusion: Despite the literature showing little evidence, our survey shows a widespread consensus in clinical practice across the UK that routine preoperative MRI should be performed from a risk management viewpoint. It is mandatory in our unit to perform pre-operative MRI scans on all patients with AIS and would recommend that this becomes standard practice in all other units.

Ethics Approval: None/Audit

Interest Statement: None


NS Harshavardhana UK Debnath HV Dabke SMH Mehdian J Hegarty JK Webb

Purpose: There is no consensus regarding indications for anterior release and causative factors of junction kyphosis(JK) in Scheuermann’s Kyphosis(SK).

Methods: A retrospective review of 35 patients(19♂; 16♀) who underwent surgery for SK with a minimum follow-up of 5 years was undertaken. The mean age & follow-up were 20.5(13.25–45.75y) and 9 years(5–22y) respectively. Patient demographics, clinicoradiological parameters & functional outcomes (ODI/SRS-22) were assessed. The incidence of JK was correlated with radiographic parameters & instrumentation levels. Outcomes of posterior instrumentation(GroupI-13) were compared with anterior release & posterior instrumentation(GroupII-22).

Results: Cobb Λle of ≥600 hyperextension radiographs and presence of anterior bony bridge required anterior release. JK(≥100) was seen in 12 cases (7 proximal & 5 distal). PJK was seen in cases where T3-4 was the upper instrumented vertebra(UIV). DJK was seen in patients with body mass index(BMI) of ≥30 and when LIV did not include 1st lordotic disc. There was significant difference in mean thoracic kyphosis(TK) correction between the 2 groups (35.70vs44.50;p=0.003). The mean loss of correction at 9 yrs was 5.90 and 3.40 respectively. 33/35 were subjectively satisfied with cosmesis and 28/35 patients returned to their previous occupation. Three were off work due to chronic back pain and four patients had job modifications.

Conclusion: Stiff curves require anterior release. PJK could be overcome by including T2 as UIV.

DJK could be prevented by including 1st lordotic disc in LIV. Extending lower Instrumentation to L3 would reduce the risk of implant failure in obese patients. There was no advantage of cages over rib grafts.

Ethics approval: Not applicable

Interest Statement: None (No grants obtained from any agency)


G M Quan M J Gibson

Objectives: To evaluate the early coronal and sagittal correction of main thoracic adolescent idiopathic scoliosis using pedicle screw instrumentation and to determine whether implant density influences correction.

Methods and results: 49 consecutive patients with Lenke I main thoracic adolescent idiopathic scoliosis underwent single stage posterior correction and instrumented spinal fusion with pedicle screw fixation between 2006 and 2008. All surgeries were performed in a single institution by a single surgeon using identical surgical technique and type of instrumentation. Pre- and postoperative radiographs were analyzed. The pre-operative main thoracic curve of 60.0 ± 13.4° was corrected to 17.4 ± 6.9° (69.9% correction) on the post-operative radiographs. The pre-operative thoracic kyphosis of 20.0 ± 10.2° decreased to 11.6 ± 4.9° post-operatively. There was a significant correlation between decrease in sagittal kyphosis and magnitude of coronal Cobb angle correction (P = 0.002). There was no correlation between implant density and magnitude of coronal or sagittal curve correction, with and without curve flexibility taken into consideration.

Conclusions: Pedicle screw constructs provided excellent coronal correction of thoracic idiopathic scoliosis, however this was at the expense of sagittal contour. Decrease in sagittal kyphosis correlated with magnitude of coronal correction. Bilateral segmental pedicle screw fixation did not improve curve correction compared with unilateral or alternate segmental fixation.

Ethics approval: None required. Caldicott and Data Protection Approval No. 661.

Interest Statement: None.


S Lyons S Batra A Jones J Howes P R Davies S Ahuja

Background: Satisfaction following anterior and/or posterior spinal fusion varies greatly between individuals. The aim of this study was to assess patient satisfaction with the post-operative scars following surgical correction of scoliosis.

Methods: Prospective study; 31 patients (range 10–37 years), minimum of 2 months post-operation, interviewed in clinic or over the telephone using a questionnaire.

Results: Overall, 18 (58%) patients were disappointed with their scar; it was not what they expected, Patients with anterior scars or both anterior and posterior scars were the most disappointed groups.

39% of patients felt they were inadequately informed or not informed of the nature of scar. However, over 50% of those who had a specialist spinal nurse (SSN) consultation reported the scar to be as they expected. Scar length was the main source of disappointment. 55% reported their scars as being raised (keloid), particularly at the ends. Scar colour and shape was an issue for 23%, whilst 39% experienced prolonged healing. 19 patients had a pre-op consultation with the SSN, 11 did not get this opportunity, 1 declined.

Conclusion: Clearly there’s a need for improved education and understanding with regard to the nature of the scoliosis surgical scar(s). Input from a SSN is important and surgeons must clarify exactly what they mean when discussing operations with patients. This could be done with the aid of pictograms or leaflets detailing issues discussed in consultations along with the opportunity to meet patients who have already had surgery. These measures may lead to increased patient satisfaction with surgery.

Ethics approval: Audit

Interest Statement: None


NS Harshavardhana HV Dabke UK Debnath BJC Freeman

Introduction: Capasso’s method(CM) has been described in orthopaedic textbooks to be the most sensitive tool for measuring Cobb angle in scoliosis. This method based on “bi-univocal principle” views the scoliosis curve to be an arc of circumference, to be a true reflection of angular values and hence geometrically more valid. However there is no comparative study between the established measurement tools i.e. Oxford cobbometer(OC) & Traditional protractor(TP) vs. CM. Our objectives were to to evaluate the sensitivity of CM against OC & TP in scoliosis and to determine intra & inter-observer reliability of the three methods.

Methods: Three independent blinded observers measured 24 digital AP radiographs of scoliosis on three separate occasions one week apart by CM, OC & TP. The three sets of readings obtained were statistically analysed for intra-observer (Cronbach’s alpha) & inter-observer [Inter-class correlation coefficient(ICC)] reliability.

Results: The mean Cobb angle measured by OC was 42.4(r13-91), by TP was 45.1(r16-89) and by CM was 70.4(r 20-148). The cronbach’s was 0.94 for OC, 0.91 for TP & 0.88 for CM. The ICC was 0.96 for OC, 0.90 for TP & 0.71 for CM. The measurements obtained by CM were higher than the other two methods for all magnitudes of the curves.

Conclusion: CM based on sound geometric principles is perceived to be superior to Cobb angle and has reasonable correlation(Pearson’s®=0.74) with it. However CM overestimates the magnitude of scoliosis as compared to other standard measurement tools. Management decisions based on CM would be inappropriate by current guidelines.

Ethics approval: Not applicable Interest Statement: None


S Sadani C R Jones A Seal P McShane B Bhakta R M Hall M C Levesley

The purpose of this study was to establish the a)feasibility, b) reproducibility of spinal Quantec scans (a non-intrusive surface topography system) and c) the validity of the Quantec Q-angle against Cobb angles from spinal radiographs, in non-ambulant children with cerebral palsy (CP).

Eighteen non-ambulant children (aged 5–11 years) with CP had successful clinical, radiological and Quantec assessment of their spine while seated in a supportive seating system.

Scoliosis incidence was 72%, Cobb angles ranged from 1–73° (mean 18.2°). Quantec scanning was feasible with appropriate postural support. Mean interobserver differences were 0.5 ± 5.8° (median 1.3°, 5 / 95th percentiles lying at −7.3 / 8.5° respectively). Mean differences between Cobb and Q-angle were 0.02 ± 6.2° (median 1.0°, with 5 / 95th percentiles lying at −8.2 / 7.7° respectively).

Surface topography may be used to safely monitor the spine for non-ambulant CP children. Results show similar or improved trends to previous comparisons with idiopathic scoliosis. Ovadia (2007) showed an interobserver mean difference of 6.3 ± 4.9° using an Ortelius800TM system. Thometz (2000) showed mean differences between Cobb and Q-angle ranging from 1.1–12.6 ± 4.9–10.2°. Further research is needed for the user group described in this study with larger spinal curves.

Ethics approval: Ethics approval granted by Leeds (West) Research Ethics Committee

COREC number: 08/H1307/22

Interest Statement: None


P D Turnpenny A Offiah P Giampietro B Alman A Cornier K Kusumi S Dunwoodie A Wade O Pourquié

The study aimed to develop and assess a new classification system for Segmentation Defects of the Vertebrae (SDV), a frequent cause of congenital scoliosis. Existing nomenclature for the wide range of SDV phenotypes is inadequate and confusing eg ‘Jarcho-Levin syndrome’.

A multidisciplinary group of the International Consortium for Vertebral Anomalies and Scoliosis (ICVAS) met to formulate a new classification system, based primarily on radiology. SDV are identified by number affected, contiguity, and spinal region(s). The size, shape and symmetry of the thoracic cage, and rib number, symmetry and fusion are included, and familiar vertebral morphology terms retained, together with accepted syndrome names. The terms spondylocostal and spondylothoracic dysostosis apply only to phenotypes typified by the monogenic disorders due to mutated DLL3, MESP2, LNFG and HES7 genes.

Five ICVAS members (Group 1) then independently assessed 10 new cases, inter-observer reliability assessed using kappa. Seven independent radiologists (Group 2) then assessed the same cases before and after introduction to the new system. Inter-observer reliability for Group 1 yielded a kappa value of 0.21 (95% confidence intervals (CI) 0.052, 0.366, p=0.0046). For Group 2, before introduction to the new system, 1/70 responses (1.4%) agreed with the Group 1 consensus,12 different diagnoses were offered, and 38/70 (54.3%) responses were ‘Unknown’. After introduction to the new system 47/70 responses (67.1%; 95% CI 55.5, 77.0) agreed with Group 1 consensus, a 65.7% improvement (95% CI 52.5, 75.6, p< 0.00005). The system was well received by 6/7 radiologists.

The new system was found to be reliable and acceptable.

Ethics approval: None

Interest Statement: None


TM Barton N Orpen R Ahmed

To identify changes in curve magnitude in patients with degenerative scoliosis between the lying and standing positions.

Thirty five patients who underwent surgical correction of a degenerative scoliosis were identified. The pre-operative standing antero-posterior radiographs were compared with the coronal MRI images and Cobb angles measured.

The mean patient age was 64 years old. The mean increase in Cobb angle in the degenerative curve on standing was ten degrees. This was not associated with age or magnitude of curve.

A degenerative scoliosis is often considered inflexible. These results show that such curves do retain some flexibility and therefore patients may present with dynamic symptoms not represented on supine MRI images. Furthermore, pre-operative supine radiographs will identify the degree of flexibility that can be expected intra-operatively.

Ethics approval: none

Interest statement: none


J A Cordell-Smith M Izatt C. Adam R Labrom G Askin

Study Aims: This study’s objectives were to measure pre-operative and postoperative axial vertebral rotational deformity at the curve apex in endoscopically-treated anterior-instrumented scoliosis patients using CT, and assess the relevance of these findings to clinically measured chest wall rib hump deformity correction.

Introduction: Thoracoscopic instrumented anterior spinal fusion for adolescent idiopathic scoliosis (AIS) has clinical benefits that include reduced pulmonary morbidity, postoperative pain, and improved cosmesis. However, quantitative data on radiological improvement of vertebral rotation using this method is lacking.

Methods: Between November 2002 and August 2005, 20 AIS patients with right-sided thoracic major curves underwent endoscopic single-rod anterior fusion. Preoperative and two-year postoperative CT was performed to assess axial vertebral rotation at the curve apex. Correlation between apical vertebral rotation measured on CT and rib hump measured using a scoliometer was assessed.

Results: The mean angle of correction achieved in axial vertebral body derotation at the apical vertebra measured by CT was 7.9° and equated to 43% improvement. Preoperative and postoperative rib hump deformity correction correlated significantly with CT measurements using regression analysis (p=0.03). The mean improvement in rib hump deformity was 55%. Conclusion: We believe this is the first quantitative CT study to confirm that endoscopic anterior instrumented fusion for AIS substantially improves axial vertebral body rotational deformity at the apex of the curve. The margin of correction of 43% compares favourably with historically published figures of 24% for patients with posterior all-hook-rod constructs. CT measurements correlated significantly to the clinical outcome of rib hump deformity correction.

Ethics: local committee approval

Statement of Interest: none


NW Gummerson NJ Bishop AA Cole

Purpose: to analyse the outcomes of scoliosis surgery in osteogenisis imperfecta (OI) in this single–surgeon series.

Methods: Case notes of OI patients having scoliosis surgery from September 2003 were analysed.

Results: 15 patients (three male) were identified. Mean age was 15.6 years (range 10–23). There were 11 cases of OI III and 4 cases of OI IV. The mean duration of bisphosphonate treatment was 6.1 years (range 2–10). The mean BMD was 0.840 g/cm2.

There was a double-curve in 10 cases, single-curve in 5. The mean Cobb-angle was 72°.

The standard construct was a double rod with pedicle/pelvic screws at the base, double claw at the proximal end and sublaminar wires at intervening levels. The most proximal level was T1–T4 in 13 cases. Instrumentation was carried to the pelvis in 7 cases. Intra-operative fractures occurred in 5 cases.

The mean blood loss was 999 mls (range 295–5500).

Spinal cord monitoring was abnormal in 3 cases. 1 case resulted in postoperative lower limb paralysis, which recovered.

The mean hospital stay was 7.5 days. Serious postoperative complications included one case of bilateral anterior compartment syndrome and one tibial fracture.

The mean curve correction was 31%. Two cases required revision surgery: extension of fusion to the pelvis.

The mean follow-up was 22.7 months (range 4–40). There was no measurable change in position over time.

Conclusion: Scoliosis surgery in OI is effective, but may have serious complications. Fusion to the pelvis should be considered, especially in OI III.

Ethics approval: None – Audit

Interest statement: None


C R Jones S Sadani A Seal B Bhakta R Hall M Levesley

The purpose was to develop an objective measurement system to assist in the prescription of supportive seating for non-ambulant cerebral palsy children with scoliosis.

Currently the prescription of patient’s bespoke seating setup relies on clinical skills and knowledge of trained seating staff (physiotherapists and engineers). Therefore to develop an objective measurement system to supplement this clinical approach, a user centred design approach was used.

Standard design processes presented in Pahl’s ‘Engineering Design’ (2007) were adopted, allowing in depth user involvement. Stakeholders (clinical, seating, and technical staff) were interviewed to develop requirements lists for each group. Following each development stage; task clarification; concepts; embodiment; detailed design; manufacture; and commissioning, these requirements were reviewed with stakeholders.

Requirements lists were collated to form the device specification, involving all stakeholders allowed the discussion of contradicting requirements. The final design incorporated critical aspects of seating while measuring important outcomes such as force distribution and spinal deformities.

A user centred design approach allowed for informative decision making from stakeholders, highlighting the fundamental requirements and facilitated effective solutions to meet these requirements.

The manufactured device complies with the collaborated specification, utilising stakeholder defined spinal and seating parameters. This was commissioned for use in a pilot study involving twenty non-ambulant cerebral palsy children aged 5–11 years, with high risk of scoliosis.

Ethics approval: Ethics approval granted by Leeds (West) Research Ethics Committee

COREC number: 08/H1307/22

Interest Statement: None


M N Yasin N J Oxborrow

Study Design: Case Report

Purpose: To evaluate the role of using VEPTR™ to treat kyphosis in children with Hurler’s syndrome.

Summary of Background Data: Spinal manifestations are common in children with mucopolysaccridosis (MPS) and likely to increase with advances in bone marrow transplantation. However, no optimal treatment exists in treating kyphosis in children with MPS. VEPTR™ has not been previously used in children with MPS.

Methods: Evaluate the early results of one ambulating child with Hurlers syndrome who underwent treatment for their kyphosis using VEPTR™

Results: Early results at 7 months are excellent, despite an initial wound infection treated with dressing and antibiotics. No concerns arise with their gait and they have undergone their first lengthening. Excellent correction of their kyphosis has been achieved.

Conclusion: VEPTR™ offers an excellent implant in treating a selective group of children with MPS, who may have previously been declined surgery. To our knowledge this is the first case where this technique has been attempted on an ambulating MPS child.

Ethics Approval: None

Interest Statement: None


G Cooke LM Breakwell DL Douglas AA Cole

Purpose: To assess quality of life in quadriplegic cerebral palsy (CP) after scoliosis surgery.

Methods: This is a study of 43 consecutive patients undergoing instrumented scoliosis correction for quadriplegic CP (2003–2008). The parents completed (telephone) the original DuPont questionnaire (Tsirikos et al 2004, JPO) and 4 additional questions. Each of the 17 items scores from 1 (best) to 5 (worst) with 3 being no change. Retrospective case note and radiograph review was performed.

Two patients had died by the time of follow-up (1 perioperative, 1 unrelated) leaving 41 patients (23 female, 18 male) for analysis. Mean age was 14.0 at surgery, mean follow-up of 2.6 years (0.25–5.3). GMFCS types 2–4 (8), 5 (31). Mean preoperative Cobb angle 78° and pelvic obliquity 18°. There were 34 posterior and 7 anterior and posterior instrumentations.

Results: Mean DuPont score for the original 13 questions was 2.00 compared with 1.75 in the DuPont study. The scores for individual questions ranged from 1.35 to 2.76. The mean score of the 4 additional questions was 2.43, related to transfer ability, reflux and communication. 95% of parents would recommend the surgery again. 75.6% reported an improvement in their child’s ability to sit. Cobb angle correction was 53%, pelvic obliquity correction was 47%. The mean DuPont score is not significantly correlated with Cobb angle or pelvic obliquity correction.

Conclusions: This is the first UK study evaluating the parental view of outcome for scoliosis surgery in quadriplegic CP. Outcome does not seem to be related to radiographic correction. 39 of 41 parents would recommend the surgery.

Ethics approval: none – Clinical Effectiveness Department & PALS

Interest Statement: None


C Barrett D Fender M Gibson J Nissen

Purpose of Study: Literature suggests that decompression of Chiari malformation for syrinx may influence the need for surgical correction of scoliosis: we therefore wished to review the clinical presentation, indications for surgery, complications and requirement for scoliosis correction after foramen magnum decompression in patients with syrinx, secondary to Chiari malformation.

Methods: A retrospective review of the available clinical information including clinic letters, case notes and radiology.

Results: 9 patients were identified. (Age range 4–16) 8 patients had progressive curves.

Neurological symptoms: 2 patients significant, 4 insignificant, 3 none.

Of 9 patients, 1 has not had surgery.

8 patients have had foramen magnum decompressions (+/− laminectomy, +/− duroplasty).

Complications: 1 patient required revision surgery for a radiculopathy > 1year post first operation: this patient required prolonged ventilation for MRSA chest sepsis. 1 patient developed a symptomatic pseudomeningocoele requiring lumbar drainage. All patients had improvement of neurological symptoms.

Of 8 patients having a foramen magnum decompression, 5 required scoliosis correction and 3 did not.

Conclusions: Foramen magnum decompression can relieve neurological symptoms in this cohort of patients.3 of 8 (38%) patients avoided scoliosis correction after decompression and decompression may therefore influence curve progression.

Ethics approval: Not applicable

Interest Statement: None


R. Ladenstein U. Pötschger M.C. Delay J. Whelan M. Paulussen O. Oberlin A. Craft

The Euro-E.W.I.N.G. 99 trial aimed to improve the dismal prognosis of patients with primary disseminated multifocal Ewing tumors (PDM-ET) with a dose-intense treatment concept.

From 1999 to 2005, 281 patients with PDM-ET were enrolled onto the EURO-E.W.I.N.G. 99 trial. Median age was 16.2 years (0.4–49). Recommended treatment consisted of 6 VIDE, one VAI cycle, local treatment (surgery and/or radiotherapy), and high-dose busulfan-melphalan followed by autologuous stem cell transplantation (HDT/SCT).

After a median follow up of 3.8 years, event-free survival (EFS) and overall survival (OS) at 3 years for all 281 patients were 27%±3% and 34%±4%. Six VIDE cycles were completed by 250 patients (89%); 169 (60%) received HDT/SCT. Forty-six children less than 14 years and HDT/SCT achieved a 3-year EFS of 45%. Cox regression analyses demonstrated increased risk at diagnosis for patients over 14 years (HR 1.6), a primary tumor volume > 200ml (HR 1.8), more than one bone metastatic site (hazard ratio: HR 2.0, bone marrow metastases (HR 1.6) and additional lung metastases (HR 1.5). An “up front” risk score based on these HR factors identified three groups with EFS rates of 50% for score ≤3 (82 patients), 25% for score > 3 to < 5 (102 patients), and 10% for score ≥5 (70 patients), p< 0.0001.

PDM-ET patients may survive with intensive multimodal therapy. Age, tumor volume, and extent of meta-static spread are relevant risk factors. A score based on these factors identifies PDM-ET patients may facilitate risk adapted treatment approaches.


H. Juergens D. Manner J. Gerss A. Ranft M. Paulussen U. Dirksen

Tumor size and metastases are known risk factors in Ewing tumors. Adequate staging is essential to stratify treatment intensity, but TNM staging is not established.

The validity of TNM staging was tested based on tumor volume (T1 ≤200 ml; T2 > 200 ml ≤500 ml; T3, > 500 ml), the presence or absence of lymph node metastases (N0, N1), and distant metastases (M0, no metastases; M1 lung/pleura metastases; M1a ≤5 nodules; M1b > 5 lesions; M2 bone metastases; M2a, 1 lesion; M2b > 1 lesion and/or microscopic bone marrow contamination; M3, multi-system metastases). 1799 Ewing sarcoma patients of the (EI)CESS/EE99 studies entered into the Muenster database from 1981–2008 were analyzed.

Ten-year event-free survival (EFS) was 0.46. EFS in patients without metastases (T1-3N0M0) was 0.56 compared to 0.22 in metastatic patients (T1-3N0,1M1-3), p< .0001. In non-metastatic patients, tumor volume discriminated EFS: T1:0.62; T2:0.43; T3:0.40, p< .0001. The rare event of lymph node metastases correlated with unfavorable prognosis (N0:0.47, N1:0.12, p< .0001). The difference in EFS between pulmonary, skeletal and multi-system dissemination was significant: M1:0.29, M2:0.23; M3:0.12, p< .0001. The discrimination of M1 subgroups (M1a/M1b) was of prognostic relevance (p=.0050); M2 subgroups (M2a/M2b) discriminated outcome less clearly (p=.0457).

TNM staging is appropriate in Ewing tumors and should be incorporated in future trials.


J.S. Whelan

Sarcomas account for 10% of cancers occurring in 15–24 year olds. Within this group there is considerable clinical and biological heterogeneity and incomplete understanding of optimal treatments.

Most clinical research attention has focused on the management of bone sarcomas, particularly osteosarcoma and Ewing’s tumours. Several factors have been studied which consistently identify patient groups with differing outcomes. Age at diagnosis appears to affect prognosis in Ewing’s tumours but less obviously in localised extremity osteosarcoma. Any underlying biological or treatment delivery variables which may explain these observations have yet to be elucidated. Whether different treatment approaches for bone sarcomas should be adopted for teenagers and young adults (TYA) is unclear and will require systematic prospective evaluation.

Soft tissue sarcomas affect all ages. The numerous histiotypes are not evenly distributed across all age ranges. In the progression from childhood through adolescence to adulthood, rhabdomyosarcoma is replaced as the commonest subtype by the many different subtypes recognised by adult oncologists. There is little guidance about appropriate management of ‘adult-type’ soft tissue sarcomas occurring in TYA and this group have not been systematically studied. Their representation within clinical trials may be biased towards those with adverse features. There is considerable variation in practice particularly regarding the use of adjuvant chemotherapy. Few studies address whether specific approaches to treatment are appropriate for TYA with soft tissue sarcoma.

In the future, biologists and clinicians familiar with sarcomas affecting TYA and adults need to work together to share understanding and to design rational treatment programmes aimed at improving outcomes for TYA.


I. Sultan I. Qaddoumi S. Yaser C. Rodriguez-Galindo C. Meazza M. Casanov A. Ferrari

Rhabdomyosarcoma (RMS) is one of the typical tumors of childhood and adolescence, but it is exceedingly rare in adults. Unfortunately, the treatment success achieved over the years for pediatric RMS has not translated into better cure rates for adults, who continue to have a very poor prognosis (overall survival rates of only 20–40%). To better characterize adult RMS, we performed an analysis of all RMS cases registered on the Surveillance Epidemiology and End Results (SEER) public-access database collected from various geographic areas in the United States from 1973 to 2005.

We analyzed 2600 patients, 1071 adults (> 19 years) and 1529 children (≤19 years). Tumors in adults were more likely to be at an unfavorable site (65% vs. 55%; P< 0.0001) and to have histologies that are unusual during childhood, particularly the pleomorphic subtype (19%) and not otherwise specified (43%). Regional and distant spread was not significantly higher in adults.

Adults had significantly worse outcome than children (5-year overall survival 26.6% and 60.5%, respectively; P< 0.0001). Adults had significantly worse outcome also analyzing subset of patients with similar tumors (i.e. same histotype, same stage). The most significant difference was in localized disease; 5-year overall survival rates were 82.2% and 46.8%, respectively (P < .0001). Multivariate analysis showed that age, histologic subtype, primary site location, stage, treatment with surgery, and treatment with radiation were significant predictors of survival. However, alveolar subtype and unfavorable primary site lost significance when analysis was restricted to adults.

In conclusion, our analysis confirmed that adult RMS was associated with a very poor outcome, especially in contrast to the significant improvements achieved in children treated contemporarily. The outcome for adults is consistently worse regardless of clinical characteristics, suggesting that factors other than an unfavorable clinical presentation might be involved in their unsatisfactory treatment results.


R. Gorlick

Osteosarcoma despite considerable biological and molecular heterogeneity, being defined by a phenotypic program resulting in the production of osteoid, is a relatively consistent clinical entity. Over the past 20 years a large catalogue of genetic alterations present in osteosarcoma has been compiled, but unfortunately this information has yielded little biological understanding or widely accepted prognostic factor. In an analogous manner nearly two decades of clinical trials, most incorporating new agents or intensifying therapy have not further improved the prognosis of patients with osteosarcoma. This would lead to considerable pessimism if it were not for the dramatic expansion in availability of osteosarcoma models, tissues resources as well as new agents, particularly antibodies targeted to various cell surface receptor proteins. Selecting and applying these agents will require an understanding of osteosarcoma’s unique dependencies and may also have the potential to yield biological insights. Defining these dependencies has been complicated by osteosarcoma’s genetic complexity as well as redundant expression of cell surface receptors, but efficacy of antibody-based targeted therapies may assist in defining the relative importance of receptors as well as their downstream signal transduction pathways. The availability of these new tissue resources and murine models may assist in understanding osteosarcoma’s complex biology, aid identification of biological features that can serve as prognostic factors as well as assist in the selection of new agents for clinical trials. These new resources may permit one to define the feasibility of performing a biologically based treatment selection and may have implications for cooperative group interaction. During this presentation the molecular biology of osteosarcoma will be reviewed, the available tissue resources and models will be outlined, some of the preliminary data available thus far will be presented, and this will be placed in the context of ongoing as well as planned phase 1 and phase 2 osteosarcoma clinical trials.


Full Access
S. Cockshott K. Hayward R.J Grimer

Synovial Sarcoma of the foot is the most common soft tissue sarcoma to present in the foot. Despite this, diagnosis is often delayed and treatment may be difficult. The aim of this paper is to review the presenting features, management and outcome of synovial sarcoma of the foot and to try and identify areas for improvement. 33 patients with synovial sarcoma were treated at out unit over a 25 year period. The average duration of symptoms was 125 weeks. The age range at presentation was 11 to 80 years (mean 44). The mean size of the tumour at diagnosis was 5cm in diameter (range 1–10cm). 75% of the tumours were deep at the time of diagnosis. Treatment was by amputation in 21 patients and limb salvage in 11 with 1 patient receiving palliative chemotherapy. Only one patient had local recurrence and presented with lung metastases. Four patients had metastases at diagnosis and nine developed them subsequently. Overall survival at 10 years was 53%. These results have shown that late diagnosis is common for synovial sarcoma of the foot and that by the time of diagnosis 75 % have invaded extra-compartmentally leading to a high risk for amputation. 20 patients had an inadvertent excision of the tumour before referral to our unit. Local control was best achieved with amputation. Overall survival was surprisingly poor despite successful local control. Earlier aggressive investigation of patients with foot pain or swelling but no other features may change their long term prognosis.


A. Pradhan R. J. Grimer A. Abudu R. M. Tillman S. R. Carter L. Jeys

Ewing’s sarcoma principally arises in bone but can also present as a soft tissue tumour. Very few studies have assessed the outcomes of extra-skeletal Ewing’s sarcomas. This study compares the oncological outcomes of the two forms of Ewing’s sarcomas to see if there is any difference in prognostic factors.

198 patients with primary, non metastatic Ewing’s sarcoma diagnosed between 1980 and 2005 were identified from our database. There were 118 males and 80 females with a median age of 15 years. The three most common sites of diagnosis were the femur (24%), pelvis (15%) and tibia (13%). There were 169(85%) bony Ewing’s and 29 (15%) extra-skeletal Ewing’s sarcomas. All patients received chemotherapy. 86% of the patients had surgery for local control but 28(14%) patients had radiotherapy.

The overall survival at five years was 89% and was related to the age of patient (92% < 16years p=0.005), size (p=0.03) and site of tumour (p=0.004) as well as the response to chemotherapy. There was no difference in the overall survival of patients with bony Ewing’s (90%) and extra-skeletal Ewing’s (85%) (p=0.85). There was a 10% risk of local recurrence at 5 years with site of tumour (p=0.01) and surgical excision (p=0.05) being significant prognostic factors. The risk of local recurrence was also not related to the type of Ewing’s sarcoma.

This large series has shown that the oncological outcomes of Ewing’s sarcoma is related to tumour characteristics, patient age and treatment factors and not determined by the tissue component.


D. Carrle B. Blank M. Paulussen P. Reichardt S. Bielack

Purpose: Compared to paediatric cancer patients adolescents and young adults may have disadvantaged access to care. Therefore we investigated the correlation of patient, tumour and institutional characteristics with the outcome of osteosarcoma in this age group.

Method: Analysis of consecutive patients aged 15–24 years with newly diagnosed high-grade osteosarcoma entered into the Cooperative Osteosarcoma Study Group(COSS) registry 1980–2004 and treated in pediatric (PO) or medical oncology institutions (MO). Standardised multimodal therapy according to a COSS-protocol. Event-free survival rates (EFS) evaluated in relation to patient demographics and registering institution (MO vs PO and treatment volume as: < 1, 1–3 or > 3 osteosarcoma/year).

Results: 944 patients identified (median age: 17.35 years; range: 15.01–24.99; 79% aged < 20 years). Patients > 20 years were more likely than younger patients to be treated in centers with low treatment volume (p< .0001) and MO (p< .0001) but otherwise comparable. After a median follow-up of 5.59 years (range: 0.12 – 27.92) for all patients and 8.08 years (range: 0.19 – 27.92) for 617 survivors, actuarial 5/10 year event-free survival probability (EFS) was 58%/54%. Upon univariate analysis of the total cohort neither of the institutional variables correlated significantly with EFS. There was a correlation between treatment in PO and improved EFS for patients > 20 years (p=.001) and for those with primary metastases (p=.009). Upon multivariate testing type of center (odds ratio: 1.26; p=.022) but not treatment volume were significant.

Conclusion: Within a framework of standardised regimens and consultation supportby our group’s infrastructure, similar EFS-probabilites were obtained regardless of institutional treatment volumes. Observed variations in outcome between PO and MO may be partly due to different distributions of presenting factors but deserve further investigation.


F. Sinnaeve R.J. Grimer S.R. Carter R.M. Tillman A. Abudu L. Jeys

Aim: To review our experience of managing patients with aneurysmal bone cysts (ABCs).

Method: We reviewed the medical records and radiographs of all patients with ABCs treated at our unit over a 25 year period. During that time the policy of the unit was to treat ABCs with biopsy/curettage without use of adjuvants or bone grafting. Patients were followed up with regular Xrays until healing had taken place. Local recurrences were again treated with curettage, occasionally supplemented with embolisation or bone grafting.

Results: 237 patients (128 female, 109 male), with a median age of 14 yrs (range 1 to 76), received treatment. The cyst size varied from 1 to 20 cm and the median duration of symptoms was 16 weeks (range 0 to 8 yrs). The most common sites were the tibia (55), followed by the femur (41), then the pelvis (29) and the humerus (27). Thirty-five (15%) of the patients presented with a pathological fracture.

Primary treatment was by curettage alone in 195, curettage and bone grafting in 7, aspiration and injection of steroids or bone marrow in 7, excision in 5 and observation alone in 17. The rate of local recurrence requiring further surgery was 12% with all local recurrences (but one) arising within 18 months. Local recurrence was not related to site, age, sex or whether the patient had previous treatment or not. Local recurrences were managed with curettage alone in 19 of the 23 cases, with one having embolisation, one excision and 2 curettage and bone grafting. This was successful in all but 3 cases who were controlled with a third procedure.

Conclusion: The local control rate of ABCs with simple curettage is 88%, which is as good as the results published for any other technique. We recommend biopsy in all cases with limited curettage at the same time, and many ABCs will heal with this simple procedure. Full curettage is needed for those showing no signs of healing within 4 weeks. Local recurrence is very unusual after 18 months.


J. Bokun Z. Bekic D. Grujicic Lj. Minic J. Sopta

Purpose: Treatment results in patients with Ewing tumors of the vertebrae were analyzed.

Patients and Methods: Between June 2000 and April 2007 7 patients with primary tumors of the thoracic or lumbar vertebrae were treated. No one patient had primary tumor of the cervical vertebra. The median ageat diagnosis was 13 years (range, 12 to 18 yrs.). Primary sites: thoracic5, lumbar 2. No one had metastases at diagnosis. Surgery was performed in 5 pts. Complete surgical excision in 2 and maximal tumor reduction in 3.Only biopsy was in 2pts. After surgery all pts. received chemotherapy: EICESS 92 (EVAIA chemotherapy regimen) in 4 pts. and Euro Ewing 99 in 3 pts. Radiotherapy was performed in 6 patients: after 2 cycles of chemotherapy in 2 pts., after 3 cycles in 4 pts. Median dose 5040cGy (range 5018–5400cGy) in conventional fractionation. Daily fractionation from 180–193cGy.

Results/Discussion: The mean follow-up was 41 months (range 4–104 months). Overall survival (OS) rate was 71,42 %. One patient progressed and died after complete treatment, another one died during chemotherapy before radiotherapy. In our series of Ewing’s Sarcoma of the vertebrae, good surgery initialy, early definitve radiotherapy and aggressive multimodal therapy (surgery/radiotherapy/chemotherapy) may be effective in disease control and survival.


AH Krieg M Mani BM Speth PD Stalley

This study reviews the implantation of extracorporally irradiated autografts as a treatment modality and alternative for pelvic Ewing’s Sarcoma.

We identified 13 cases between 1994 and 2004 (7 male, 6 female), with mean age 14 years (6.5–34.5). The disease free survival was 69% overall, (75% excluding one case initially treated elsewhere) with a mean follow-up of 6.1 years (3.1 – 8.2). Four patients died with distant metastases at a mean time of 17 months (13–23).

Functional results showed a median MST-Score of 86% (IQR 68.5 to 91.5), a median TES-Score 85% (IQR78.5 to 93.5) and a median Harris Hip-Score 89% (IQR 82.5 to 96.5).

Solid bony union was observed at all osteotomy sites. Consolidation was achieved after median 6 months (IQR 5 to 7).

There were three complications (23%) which required operative intervention, one (8%) due to infection, which required removal of the autograft.

Advantages with this technique include ideal fit in the defect and thus promotes healing through greater contact at osteotomy junctions. It avoids early and late loosening and/or breakage of a prosthesis. It acts as a biological bridge for creeping substitution and bony incorporation in the defect. It allows re-attachment of tendons and ligaments, and thus preserves anatomic relationships. There is no risk of disease transmission or immunological reactions. It is cost effective and convenient in any institution with radiotherapeutic equipment.

We conclude this is an appropriate treatment option for localised and resectable pelvic Ewing Sarcoma.


M. Paulussen A. Ranft U. Dirksen H. Jürgens

Background: Intensive chemotherapy in sarcoma treatment may lead to weight loss, and in turn reduce dose intensity. A possible correlation between weight loss under treatment and outcome has never been analysed in sarcoma treatment. Ewing sarcoma (ES) patients undergoing intensive non-corticosteroid-containing chemotherapy commonly experience weight loss. The German Paediatric Oncology/Haematology Society (GPOH) Ewing sarcoma trials (CESS, EICESS) registry was analysed with respect to weight loss and outcome.

Patients and Methods: Body weight (BW) both at diagnosis and after a median of 12 courses of chemotherapy was available in 837 of 1549 ES patients, excluding amputees. Changes in BW were calculated as percentage of initial BW; outcome was determined as event-free-survival (EFS) from diagnosis according to Kaplan-Meier. Correlations of BW and outcome and potential confounders like disease stage or tumour volume were estimated uni- and multivariately.

Results: Weight loss was not correlated with inferior outcome: A loss of 10%–20% of BW was associated with a slightly more favourable outcome (3-year EFS 0.64 +/−0.106, N=82) than weight gain of 10%–20% of BW (3-year EFS 0.58 +/−0.098, N=97), p=0.101. Multivariate analyses revealed no confounders interfering with these results.

Conclusions: In 837 ES-patients analysed, weight loss did not correlate with inferior outcome. This should be observed in discussions about tube feeding and/or parenteral nutrition under cytostatic therapy. Future analyses of the prognostic impact of extreme under- or overweight both at diagnosis or under treatment are warranted in order to develop appropriate guidelines. Validity of this observation should be analysed for other solid tumours.

Supported by EC Biomed and Deutsche Krebshilfe


Y. Panchwagh N. Fabbri M. Serra S. Ferrari P. Picci M. Mercuri

Osteosarcoma is the most common second malignancy seen in retinoblastoma survivors. Risk of developing osteosarcoma in this group is estimated approximately 500 times higher than the general population. Prognosis in this setting has been reported significantly worse than conventional osteosarcoma despite multimodal management. Purpose of this study was to evaluate clinical features, molecular aspects and outcome of treatment in this subgroup of osteosarcoma patients.

Between 1985 and 2004, from a total of about 1100 osteosarcomas, 7 survivors of retinoblastoma developing high-grade osteosarcoma as second malignancy presented at the authors’ Institution. Retrospective study was undertaken to analyze presentation, tissue expression of RB1, P53, PGP and DHFR, treatment and outcome of both retinoblastoma and osteosarcoma.

Retinoblastoma was bilateral in 5 cases and unilateral in two. All the patients had been treated with a combination of surgery +/− chemotherapy +/− radiation.

None of them had evidence of retinoblastoma at the time of second malignancy diagnosis. Average age at diagnosis of osteosarcoma was 14 years (9–17 years), mean interval between the two malignancies was 155 months. All the osteosarcomas were in the appendicular skeleton, all but one around the knee. Molecular analysis showed defective RB1 gene in all cases All the seven patients received contemporary multimodal management for osteosarcoma. All but one patient died of osteosarcoma within 30 months from diagnosis. The living patient had local recurrence 9 years after limb salvage and is currently disease free following amputation.

Prognosis of osteosarcoma in retinoblastoma patients remains poor as compared to conventional high grade osteosarcoma despite multimodal management. No obvious correlation was found between poor prognosis and P53, PGP and DHFR expression.


A.V. Igoshin A.V. Shvarova N.M. Ivanova M.D. Aliev

We analyzed the results of the intensive multimodality therapy of children with localized Ewing’s family tumors of the ribs (EFTR). 22 patients with localized EFTR were treated in our institute between 1996 and 2006. The age is ranged from 4 to 15 years. 10 patients were male, 12 – female. Eight patients had a classic Ewing sarcoma(ES), 14 – PNET. The high risk criterion was tumor volume over 100 ml. The treatment plan included intensive induction chemotherapy (adapted to risk group) consist of 5 courses (1, 3, 5 courses – vincristine, adriamicin, cyclophosphamide, 2, 4 courses – ifosfamide and etoposide) and local control (surgery and radiotherapy), and consolidation with or 5 courses standard therapy or high-dose chemotherapy with stem-cell rescue. 4 patients underwent high-dose chemotherapy, 18 – consolidation with standard arm.

Two patients died from complications of chemotherapy, 20 patients completed the treatment. 5-year overall survival (OAL) of patients was 70±10,4%, 5-year event-free survival (EFS) was 58,9±11,4%. We conclude that Ewing’s family tumors are the most common tumors of ribs in childhood. Improved EFS requires more aggressive systemic chemotherapy and surgery (removing of entire affected ribs). Long-term survival is possible, even for high risk patients.


Z. Bekic D. Mandaric Z. Vucinic V. Ilic I. Tufegdzic J. Sopta

Objective: The aim of our study was to evaluate results of chemotherapy regimens and analyse prognostics factors in children with relapse of osteosarcoma.

Patients and methods: From 2000–2007, we treated 57 patients with non metastatic osteosarcoma, median age 15,5 years (range 3–18). 29 pts relapsed. 26 pts with osteosarcoma relapse were treated, and 3 pts with OS relapse refused the treatment. In 24 pts pulmonary metastases were detected (7 solitary), while 2 pts had local relapse of disease. Disease free interval (DFI) was more than 1 year in 12 patients. Surgery was performed in 20 pts (17 thoracotomy, 3 amputation). Chemotherapy regimens administered were: HD IFO-VP16 (11 pts), HDMth/IFO-VP16 (6 pts), HDMth/Carbo-VP16 (9 pts).

Results : During 8–116 months follow up period (Me=32 mts), disease free suvival rate was 33.12%. There was no significant difference in survival in relation to the type of chemotherapy regimen applied.Prognostic factors that influenced survival were: presence of a solitary metastasis (p= 0.026), local relapse of disease (p= 0.002), completeness of resection (p=0.043) and DFIlonger than 1 year (p= 0.039).

Conclusion: The use of aggressive multimodal therapy (surgery/chemotherapy) and evaluation of prognostic factors are necessary for successful treatment in patients with osteosarcoma relapse. Chemotherapy regimen HD IFO-VP16 had better initial tumore response, but in longer follow up the survival rate was similar to other chemotherapy groups.


E. Ebeid W. Ebeid

Osteosarcoma is the most common bone tumour of the paediatric age. Long time survival can be reached in 70% of patients when metastatic disease is absent at presentation. But in spite of aggressive chemotherapy regimens, about 30% of patients die of the disease.

This retrospective study was carried on 120 patients with primary non-metastatic osteosarcoma of the extremities, attending at Cairo University Hospitals (Faculty of Medicine and National Cancer Institute) between January 1993 and June 2006. The patients’ functional outcome was evaluated according to the Musculoskeletal Tumor Society Functional Rating System.

All patients have undergone surgical resection of the tumour and limb salvage. They have received different chemotherapy regimens depending on the time of entry to the study. Four patients were treated according the Osteosarcoma Group Study I (OSGI): six courses of adjuvant cisplatin and doxorubicin. Twenty patients received OSGII: 2 neoadjuvant and 4 adjuvant courses of cisplatin and doxorubicin. Twenty-nine patients received OSGIII: high-dose methotrexate, ifosfamide, doxorubicin, and cisplatin. Sixty-seven patients received OSGIV: high dose cisplatin, ifosfamide, doxorubicin and a cardioprotective agent. Patients with limb salvage surgery were divided into 3 groups: mobile joints (33 patients), fused joints (75 patients) and rotation plasty (12 patients).

The 5-year event free survival and overall survival for the 120 patients were 70.9 % and 71.3% respectively at median follow-up of 54.5 months and a range of 5–153 months. Functional outcome for available patients according to MST rating system was < 70% in 34 patients and > 70 % in 86 patients. There was not a statistically significant difference between survival and different prognostic factors (age, sex, tumour site, tumour size, tumour necrosis, pathology and time of chemotherapy). Only serum LDH and alkaline phosphatase were statistically significant when correlated with survival.

The results of this study seem to be in accordance with other studies in the literature.


A.T. Amiraslanov

Purpose of this study was to share our experience with combined therapy of patients with osteosarcoma of long tubular bones.

We have analyzed 173 patients with osteosarcoma-99 males and 74 females. The mean age was 18,5 years. Anatomical location included: femur-89 (51,4%) pts, tibia-41 (23,7%) pts, humerus-35 (20,2%) pts, other long tubular bones-8 (4,7%) pts. The following surgical procedures were performed: prosthetic reconstruction of the knee joint-71 (41,1%) pts, prosthetic reconstruction of the shoulder joint-14 (8,1%) pts, interscapular-thoracic resection-16 (9,2%) pts, segmental resection of bones with applying of Ilizarov’s device-4 (2,3%), amputations and exarticulations-68 (39,5%) pts.

In all patients we have carried out combined therapy. In case of lower extremity tumour localisation at the first stage we have performed intra-arterial preoperative chemotherapy of DOX 90 mg/m2 as 72-hour, at the second stage surgery. The histological response was evaluated according to Huvos score. Adjuvant chemotherapy in good responders (grade III-IV) comprised the drugs used preoperatively, in poor histological responders (grade I–II) CAP scheme. In some patients ifosfamide and etoposide were added. In case of upper extremity tumour localisation induction chemotherapy consisted of 3 cycles of CAP scheme, surgical treatment and adjuvant chemotherapy with CAP scheme (3 courses) in good responders. In poor histological responders we have added ifosfamide and etoposide.

At localised forms of osteosarcoma 5-years survival rate was 52,1±1,4%. Functional results are good in most patients. Without extra support move about 80% patients. At local-spread forms survival at 5-years is worse- 48,1±1,2%.

In patients with metastatic disease we have not observed full remission. Achieved results testify that combined therapy (surgery and chemotherapy) is optimum at treatment of patients with osteosarcoma at present day and permits to attain full recovery and to improve life quality of patients.


G. Machak B. Polotsky I. Tiurin O. Meluzova I. Chernov M. Aliev

The purpose of study was to evaluate retrospectively the efficacy of Ifosfamide-Carboplatin containing chemotherapy in recurrent/refractory osteosarcoma and MFH of the extremities.

Twenty seven osteosarcoma and 2 MFH pts who had achieved complete surgical remission after multimodal treatment and then progressed soon after en-bloc bone resection or developed recurrent disease were included in two chemotherapy protocols. There were 20M/9F with ages ranging from 15 to 36 yrs (mean 20). Chemotherapy consisted of ifosfamide (median dose per cycle 7.5 g/m2) + carboplatin (median dose 350 mg/m2) + etoposide (median dose 450 mg/m2) – (regimen ICE) or doxorubicin 60 mg/m2 (regimen ICA). Response was evaluated according to RECIST. Survival was calculated from the time of R1 to death and analyzed as February 11, 2009.

In total 93 (from 1 to 5. mean 3) cycles were administrated between October 2003 and December 2008. Of 17 ICE pts 3 had PR (17.6%), 10 had SD (58.8%) and 4 (23.5%) – PD. Among 12 ICA pts 3 (25%) had PR, 6 (50%) had SD and 3 (25%) had PD. Sixteen pts (55%) without progression during chemotherapy achieved second surgical remission. At last follow-up 12 pts died of disease, 8 are AWD and 9 are NED. Actuarial 5-year survival was 35±16%, median 38 mos. Outcome was related to relapse-free interval. Five-year survival was 23±18% among patients who relapsed < 12 mos after CR1 and 64±18% among pts who relapsed later, p=0.3. 5-year survival was significantly better in pts in whom chemotherapy was followed by surgery for distant metastases − 37.8±27% (median 38 mos), versus 23.3±19% (median 11 mos.) in patients treated without surgery, p< 0.05.

We conclude that retrieval chemotherapy stopped disease progression in the majority of cases. Followed by surgery it was associated with better survival. These regimens and treatment strategy need further investigation in prospective trials.


W. Ebeid A. Ghoneimy A. Nassef E. Ebeid

Patients with high-grade osteosarcoma who have been previously misdiagnosed as benign lesions or infection and accordingly been treated by curettage, internal fixation or drainage present a challenge in deciding the most appropriate treatment plan. Since one of the contraindications of limb salvage is the inability to achieve a wide surgical margin, there has been a tendency to treat these patients by amputation. Due to contamination by previous surgeries, limb salvage surgery was thought to be associated with a higher risk of local recurrence.

The aim of this study was to evaluate the oncologic outcome following limb salvage surgery done for high-grade osteosarcoma patients who were initially treated inadequately by curettage, internal fixation or drainage.

The study included 24 patients (14 males and 10 females) with an average age of 19 years (range 7 to 39 years). All the patients had high-grade osteosarcoma of the extremities. Seven were located in proximal tibia, six distal femur, four proximal humerus, three proximal femur, two distal tibia, one distal radius and one fibula. 14 patients were previously diagnosed as benign lesions and treated by curettage. 5 patients were diagnosed as regular fracture and internally fixed. 5 patients were diagnosed as osteomyelitis and treated by drainage. The patients were staged then treated by neoadjuvant chemotherapy and limb salvage surgery. The average time between the initial procedure and the limb salvage procedure was 7 months (range 3 to 36 months). A wide resection margin was achieved in all patients.

The average follow up period was 40 months (range 18 to 110 months). Local recurrence occurred in three patients (12.5%). Three patients developed chest metastases and one patient developed bone metastases.

We conclude that patients who had an inadequate surgical procedure prior to the diagnosis of a high-grade osteosarcoma could still be treated by neoadjuvant chemotherapy and limb salvage surgery without a significant increased risk of local recurrence and chest metastases.


I. Ługowska W. Woźniak T. Klepacka E. Michalak M. Karwacki M. Rychłowska-Pruszyńska K. Szamotulska

In osteosarcoma, treatment guidelines recommend standard chemotherapy regardless of severity of disease. Treatment individualization will minimize risk of failure and adverse effects, specially in patients who have good prognosis. Therefore, there is a pressing clinical need to develop a risk adapted strategies and to adjust chemotherapy to prognostic factors.

Aim: to asses usefulness of Classification and Regression Tree Analysis (C& RT) for stratifying patients with localised osteosarcoma to the risk groups according to clinical and biological markers.

Material and methods: 100 patients with localised osteosarcoma were included, aged 5–23 years (mean 14), with extremity localisation of the primary tumour. Follow up – at least 5 years since a date of diagnosis. We analysed clinical prognostic factors (tumour size, pathological fracture, alkaline phosphatase, age), histological prognostic factors (% of viable tumour cells after pre-operative chemotherapy, subtype of osteosarcoma and its aggressiveness) and biological factors (expression of VEGF, Ki-67, Topoisomerase II alpha and P glycoprotein). The expressions of proteins were measured immunohistochemically in biopsy samples. C& RT model included all described above factors.

Results: C& RT analysis revealed that the most important prognostic factors in localised osteosarcoma were: VEGF, Topoisomerase II alpha and tumour size. This markers were included into the risk classification and three risk groups were proposed: with poor prognosis (n=13) – 5 year OS 31%, moderate (n=57) – 5 year OS 63% and with good prognosis (n=30) – 5 year OS 93%), P=0.000.

Conclusion: C& RT is useful method for stratifying patients with osteosarcoma to risk groups. The stratification should include biological and clinical prognostic markers.


A. Bonevski J. Stepan Giljević G. Jakovljević M. Rimac M. Nakić

Osteosarcoma is the most frequent bone tumor in adolescents and young adults. Already, the bisphophonates were introduced as the first line therapy for metastatic disease as well as the maintenance therapy, but new drugs are still in researchers interest.

Between 2005 and 2008, we have been treated 17 osteosarcoma patients, from 4 till 18 years of age. All patients have been followed up for 11 months average (range 4–18). At the time of diagnosis 15 of them had local disease, and 2 had metastatic disease. They were treated according to EURAMOS protocol. There were two groups of patients; the high risk patients who has received the pamidronat disodium (pamidronat) after the standard postoperative chemotherapy, and the other group who hadn’t received pamidronat. One patient, who had bone and pulmonary metastasis at the diagnosis, received the pamidronat as the first line therapy. We have introduced the 2 mg/kg mothly of pamidronat to 7 patients, median age of 13. Patients have received 8 cycles average of pamidronat (range 4–12). Two patients had to be excluded from therapy due to nephrotoxycity and pregnancy. The patient with metastatic disease, bone and lung metastasis, at the diagnosis, had died, and two patients who had pulmonary metastasis, afer the surgery and second line chemotherapy, showed no disease progression during the pamidronat therapy. In the other group of patients, who hadn’t received the pamidronat, one patient with metastatic disease had died, 2 of them had local reccurence, and 2 died due to disease progession.

Introducing the pamidronat has been a big step forward for osteosarcoma patients, because, according to our results, during the pamidronat therapy they haven’t developed local recurrence and/or disease progression.


A.V. Shvarova K.F. Savlaev M.S. Kubirov A.V. Igoshin N.M. Ivanova M.D. Aliev

The aim of our study was to increase of survival of children with osteosarcoma by intensification of chemotherapy by inclusion of high dose methotrexate. 53 patients were treated in our centre between 2003 and 2007. Age are ranged from 5 to 16 years. 23 (43,4%) patients had metastetic disease. Polychemotherapy consist of alternating courses of CDDP, adriamicin, ifosfamide and etoposide and high-dose methotrexate (8–12 g/m2). In 25 (51%) cases have been received objective response (CR+PR). 38 (71,7%) patients alive at present time. 2 patients died from complications of treatment. 7 patients had PD, 1 — local relapse, 4 — metastatic relapse, 1 — combined relapse. 2-year OAS was 75,2±6,8%, 2-year RFS was 65±7,8%.


Full Access
P.C.W. Hogendoorn

While classically bone tumors were classified according to the differentiation and cellular morphology at the light microscopical level, it has become clear that over the past decade the array of knowledge which became available on the cytogenetic and molecular genetic level should influence tumor classification. This lead to an integrated approach in drafting the 2002 WHO nomenclature for bone tumors in which morphology was combined with the evolving genetic information. With regard to bone tumorigenesis distinct patterns can be recognized with regard to underlying genetics:

balanced translocations such as in Ewing sarcoma, or aneurysmal bone cysts

numerical chromosomal abnormalities like in adamantinoma

complex karyotypes with as yet no identified starting point from a genetic point of view such as in osteosarcomas or central chondrosarcomas

single gene events such as in fibrous dysplasia or osteochondroma

These different pathways in oncogenesis open an array of possibilities for studying the drivers in oncogenesis. Especially those pathways essential in keeping the proliferative state as opposed to the ones governing differentiation might proof to be potential targets for tailored drug treatment. Here high throughput screens focusing on kinase activity appear especially of interest. Within the EuroBoNeT consortium (www.eurobonet.eu) several working groups act transnationally together in unraveling these events. Important key elements of study are the molecular-genetic networks involved in skeletogenesis as well, which amongst others are studied within the consortium using in vitro systems as well as in vivo models using xenografted mouse models, mesenchymal stem cell models and models exploring zebrafish development.


I. Ługowska W. Woźniak J. Ambroszkiewicz J. Gajewska K. Szamotulska

Serum level of the extracellular domain of HER-2 (ECD/HER2) has been suggested to be a tumor marker in breast cancer. The aim of this study was to assess the prognostic value of baseline level of ECD/HER2 and changes in levels over time in children and adults with osteosarcoma during chemotherapy.

Materials and methods: We analysed 33 newly-diagnosed osteosarcoma patients treated at the Department of Paediatric Oncological Surgery of the Institute of Mother and Child, Warsaw, Poland between 2005–2008. Patients characteristics: age 8–18 years (median 15); staging at diagnosis: disease localised (18) and dissemination (15); disease progression (13); deaths (6). Follow-up: 8–37 months (median 19). ECD/HER2 was measured in 118 serum samples using a validated ELISA kit: at the time of diagnosis (1), after preoperative chemotherapy (2), 2 weeks after surgery (3) and 3–6 moths after surgery (4).

Results: The baseline level of ECD/HER-2 in serum ranged 3.8–34.4 ng/mL (median 5). The elevated baseline ECD/HER2 was associated with decreased progression free survival (ECD/HER2 ng/mL> 5 vs ECD/HER2 ng/mL≤5: 44% vs 77%; p=0.039) and decreased overall survival (ECD/HER2 ng/mL> 5 vs ECD/HER2 ng/mL≤5: 69% vs 94%, p=0.115). The concentration of ECD/HER2> 6 ng/ml during treatment (specially postoperative chemotherapy) was associated with early disease progression (p=0.095).

Conclusions: The high level of ECD/HER2 at the time of diagnosis may be a marker of poor prognosis in osteosarcoma. Additionally, we suggest that changes of this marker concentration over time could be helpful for treatment monitoring.


H. Bürger

Networks of Excellence (NoE’s) are an instrument to overcome the fragmentation of the European research landscape with the objective to strengthen European excellence in a given area. Their purpose is to reach a durable restructuring/shaping and integration of efforts and institutions or parts of institutions in areas where this is necessary. The success of a NoE is not measured in terms of scientific results but by the extent to which the social fabric for researchers and research institutions in a given field has changed due to the project and the extent to which the existing capacities become more competitive as a result of this change. With that background a “European Network to promote research into uncommon cancers in adults and childrens: Pathology, Biology and Genetics of bone tumours” was initiated and founded by the European Commission in 2005 with the involvement of more than 20 institutions all over Europe.

Osteosarcoma research represents an own research line within this network. Up to now a multitude of experience has accumulated over the years which will be presented. The obvious advantages of a close cooperation between the network partners are a major hallmark and success of the network and should further lead to an improved translation of the basic research results towards a clinical application.


L. Aung Y.H. Chan A.M. Tan S.S. Nathan E.J. Yeoh T.C. Quah R.W. Pho

We attempted to investigate the incidence, the treatment modalities used and the outcome of Osteosarcoma (OS) patients treated at the two major Pediatric Oncology Hospitals in Singapore. A comprehensive list of patients with OS treated at the National University Hospital and KK Women’s and Children’s Hospital Singapore between April 1980 and May 2006 was generated. During the study interval, patients received neoadjuvant chemotherapy followed by definitive surgery consisting of either limb salvage or amputation followed by adjuvant chemotherapy. Chemotherapy was as per the European Osteosarcoma Intergroup (EOI) and as per the Memorial Sloan-Kettering Cancer Center’s (MSKCC) T12 protocols. Treatment of subsequent relapses consisted of various combinations of Methotrexate, ifosfamide, etoposide, other, and/or surgery.

Of the total 49 patients with OS, 30% presented with metastatic OS. Median age of diagnosis of OS was 12.4 years. For the cohort, two and five-year overall survival were 71% and 55% respectively. The two-year overall survival was 73% for patients who were treated as per the MSKCC protocol. At last follow-up, median 4.3 years (range, 0.3 – 21.6 years), 25 were alive with no evidence of disease and 16 were dead of disease.

Survival from OS in Singapore appears to be improving. Rarity and complexity of OS makes it crucial for patients to seek a centralized multi-disciplinary Musculoskeletal Oncology team involving surgeons and Pediatric Oncologists dedicated to the care of these young patients with the intent to cure.


B. Morland G. Vassal H. Caron

ITCC was created in 2003 as a European network to support the introduction of new therapies into the paediatric cancer population. There are two core arms to the network. Firstly a biology programme to evaluate new compounds in a preclinical setting with the aim of prioritising drugs for further clinical evaluation. Secondly a network of clinical centres in Europe able to deliver high quality Phase I and II clinical trials.

To date nine research laboratories are participating in the biology programme linked by a consortium agreement. These laboratories include specialist units focusing on rhabdomyodsarcoma, Ewings sarcoma and osteosacrcoma. A large biological resource of tumour samples, cell lines and gene profile data is available through this network. The clinical trials programme has identified and accredited 36 centres in six EU Member States to conduct clinical trials.

ITCC has become recognised as the major academic network for drug development in paediatric cancer in Europe. Strong collaborations have been forged with the pharmaceutical industry, and regulatory authorities to capitalise on the emerging EU legislation facilitating the development of drugs for children. We are also in a strong position to advise and partner with the major disease-specific groups developing Phase III trials in a range of tumours such that new therapies can be introduced appropriately into front-line treatment.


U. Dirksen M. Nathrath K. Agelopoulos S. Fulda G. Richer D. Dilloo U. Kontny P. Lang P. Bader J.T. Hartmann E. Korsching L. Schäfer St. Bielack T. Klingebiel H. Jürgens

Sarcomas are rare malignant tumors of mesenchymal origin and primarily occur in children, adolescents and young adults. With multimodal treatment concepts survival has significantly improved and is now in the range of 60–70 %. Following relapse or metastasis, however, the prognosis still is poor as is also the case for patients presenting with primary disseminated disease. TranSaR-Net aims to develop novel treatment strategies overcoming tumor cell resistance directed against novel targets. To achieve this goal the German pediatric, adolescent and adult sarcoma research groups have formed a collaborative network linking the nationwide and European trial groups with access to over 90 % of all pediatric and adolescent sarcoma patients and a large number of adult sarcoma patients to basic and translational sarcoma research groups. Within TranSaRNet a registry for patients at relapse is established as target cohort for innovative treatment strategies as well as a biomaterial banking network in order to facilitate the availability of tumor and other biomaterial for basic and translational research. A joint bioinformatics platform will integrate existing array data, to standardize laboratory and evaluation procedures and for modeling new theoretical concepts in a joint effort. Within the basic and translational research work packages, the sarcoma research groups in Germany have coordinated their research activities in a joint effort. The basic research work package (WP1) includes projects on genomic (WP1.1) and epigenetic (WP1.2) tumor characterization as well as identification of the tumor initiating cell (WP1.3) and resistance mechanisms (WP1.3 und 1.4), and the identification of new targets in apoptotic pathways (WP1.4, 2.4) and tumor-induced angiogenesis (WP1.5). The translational research work package (WP2) is focused on innovative immunological treatment strategies including sarcoma specific T-cells (WP2.1), dendritic cells (WP2.2), NK- cells (WP2.4) and tumor imaging (WP2.3).

A brief overview of the projects will be provided.


JY Blay

The CONnective TIssue CAncers NETwork to integrate European Experience in Adults and Children (CONTICANET) is dedicated to improve the outcome of connective tissue cancers in adults, adolescents and children. Funded by the European Commission’s Sixth Framework Program (FP6-018806), this Network of Excellence kicked off in February 2006 for a five-year period. Ten work packages are grouped around the themes of “Integration” “Common research programme” and “Dissemination of excellence”. A consortium of 24 different organisations – cancer centres, academic institutions, patient advocacy groups and private enterprises – hailing from 9 countries (Belgium, France, Germany, Ireland, Italy, the Netherlands, Spain, Slovenia, UK), including > 250 researchers, is involved in collaborative research efforts that will help propagate excellence in the field. Improving the management of these tumours will come out the following outputs of the network activities:

Epidemiology

Molecular characterisation and nosological classification

Understanding the deviations of medical practices and initiating corrective strategies

Identifying new molecular targets and targeted treatments

Promoting clinical research on very rare subtypes

Addressing specific age (paediatrics, adolescents) or condition (Recklinghausen) group issues

Organisation of the collection and storage of biological samples

Standardisation of their management

Identification of centres of excellence for pathological and biological management and clinical management, and the scientific promotion of shared and multidisciplinary research programs.

In addition, CONTICANET will integrate the expertise from other networks through collaborations, such as clinical research networks (EORTC, National sarcoma groups), other networks (EUROBONET, networks on rare tumors and paediatric/adolescent tumors). Afyer 5 years a legal entity will continue to spread excellence in several directions: enlarging the network with academic and private organisations; continuing to enhance relations with EMEA, health authorities, patients advocacy groups, cancer leagues. Together, we aim to a European research foundation able to support integrated research actions and make available new treatments in these diseases.


K. Scotlandi A. Bernard F. van Valen S. Knuutila A. Llombart-Bosch H. Kovar B. Perbal C. Malvy M. Gottikh

With modern polychemotherapy Ewing’s sarcoma exhibit remarkable chemosensitivity leading to 5-year survival rates approaching 60–70%. However, in the last decade, no significant progress has been achieved in terms of improved cure rates and quality of life. In addition, prognosis is poor either in relapsed patients and in patients with metastasis at diagnosis. Thus, it is imperative to develop novel therapeutic strategies and to identify markers for risk-adapted therapies.

The PROTHETS European Consortium through collaborative studies defined prognostic markers and new therapeutic targets in the Ewing’s sarcoma family of tumours (ESFT), to provide rigorous scientific justifications for the development of clinical trials for this rare disease. Genetic studies have been performed for the screening of high-risk patients and patients responding differently to chemotherapy.

Between others, these studies identified in gluthation metabolism a major pathway regulating Ewing’s sarcoma chemoresistance. The prognostic relevance of glutathione metabolism pathway was validated by RT-PCR and the expression of MGST1, the microsomal glutathione transferase (GST), was found to clearly predict EWS prognosis. MGST1 expression was associated with doxorubicin chemo sensitivity. This prompted to assess the in vitro effectiveness a new anticancer agent (NBDHEX) that efficiently inhibits GST enzymes..

The consortium have collected more than 600 cases in specific tissue arrays for validation studies. Their use allowed the identification of some markers of prognosis, either conventional or new (ki-67, adhesion proteins, GAL3BP). Overall, theses studies started to define possible forthcoming risk-adapted strategies.

Another goal of the project was the creation of new tools and drugs as well as the optimization of molecular approaches against three therapeutic targets, EWS-FLI1, CD99 and IGF-IR that have great potential in terms of clinical application. The studies on IGF-IR have provide the rationale for the currently on-going clinical studies in Ewing’s sarcoma.


H. Caron G. Vassal T. Pietsch O. Delattre M. Serra J. Shipley M. Boer den S. Clifford A. Verschuur R. Versteeg

In this lecture I will present an update on the activities of the European KCK (KidsCancerKinome) consortium. Nine European research centers devoted to molecular-biologic, pharmacologic and clinical studies of childhood cancers and two SMEs are engaged in the KidsCancerKinome consortium. The research centers already have an established collaboration for pre-clinical evaluation of anti-cancer compounds in the European ‘Innovative Therapies for Children with Cancer’ consortium (ITCC).

The KidsCancerKinome consortium aims to perform a comprehensive analysis of the human protein kinase family in childhood tumors, as protein kinases are excellent targets for small inhibitory molecules designed for adult tumors, and many more of such drugs are currently in development. Six aggressive childhood tumors, killing ~2000 children in Europe annually, will be addressed, i.e Ewing sarcoma, osteosarcoma, rhabdomyosarcoma, neuroblastoma, medulloblastoma and ALL.

The KCK consortium has generated gene expression profiles (Affy U133plus2 arrays) of > 500 tumor samples form those six tumortypes. We have performed extensive analyses of mRNa expression of human kinases. Examples of interesting expression patterns of the human kinome will be presented. Detailed analyses for the first 5 kinases for which targetted drugs are available, i.e. PI3K, IGF1R, AURKA+B, and CDK2 will be presented.

Lentiviral shRNA mediated knockdown of kinase protein expression has been used in cell lines to validate those kinases as drug targets.

Many novel kinase inhibitors are under development for adult oncology and KCK will test their in vitro activity against the tumor-driving kinases identified in this program. We are currently testing small molecule inhibitors for the first 5 kinases. For those kinases that have no small molecule inhibitors, a novel generation of siRNA based nucleic acid drugs (LNAs), produced by the Santaris company, will be applied and tested in vitro. Successful small molecule inhibitors and LNAs will be taken further to in vivo validation in established xenograft models of the six childhood tumor types. Pharmaco-kinetic studies of these drugs will finally prepare them.


S. Smeland S. Bielack M. Sydes T. Butterfass-Bahloul G. Calaminus N. Marina M. Tomiczek J. Whelan M. Bernstein

The European and American Osteosarcoma study group (EURAMOS) was formed by four multinational study groups (COG, COSS, EOI, SSG) based upon a common understanding that broad international collaboration facilitating randomised trials was important for further progress in the field of osteosarcoma. Representatives from each group reached quick agreement on a study design; to determine whether altering post-operative therapy based on response to pre-operative chemotherapy improves outcome. Additionally, a quality-of-life sub-study was included in the project. After a three-year process to resolve regulatory and organisational issues the study opened for accrual in April 2005. Important for an efficient conduction of the trial a common infrastructure was established with central sponsorship (Medical Research Council, UK), one coordinating data centre (MRC Clinical Trials Unit, UK) and a common Safety Desk and a coordinating Quality-of-life data centre (Münster, DE).

As of Dec 2008, a total of 1268 patients from 290 institution in 15 countries have been registered into the trial (AUS 16 patients; B 27; CAN 54; CH 26; D 266; DK 12; FIN 3; H 14; NL 61; NOR 23; NZ 8; OST 7; SWE 25; UK 174; USA 552) and 937 patients participate in the quality-of-life evaluation. 697 patients have been randomized and 53% are assessed as good histological responders. Due to a lower than expected randomisation rate and a higher than expected number of patients with a good histological response the accrual time will be extended by one year to summer 2010.

In conclusion, EURAMOS-1 may serve as a model for a successful non-commercial multinational clinical trial in times of increasing economic and regulatory pressure. It is the fastest accruing and largest osteosarcoma trial ever. In addition, to addressing important questions in a randomised setting a common language in osteosarcoma has been established.

Supported by the European Science Foundation (ESF) under the EUROCORES Program European Clinical Trials (ECT), through contract No. ERASCT-2003-980409 of the European Commission, DG Research, FP6


S. Ferrari S. Smeland S. Bielack A. Comandone P. Dileo P. Picci K. Sundby Hall M. Eriksson H. Honegger P. Reichardt

EUROpean Bone Over 40 Sarcoma Study (EURO-B.O.S.S.) is the first prospective multicenter international study for patients 41–65 year old with high-grade bone sarcoma

Patients with HG Osteosarcoma (OS), HG sarcoma NOS (S), Fibrosarcoma, MFH, Leiomyosarcoma, Dedifferentiated Chondrosarcoma (DCh) were included. Chemotherapy: Combinations of cisplatin/doxorubicin (CDP 100mg/m2/ADM 60mg/m2), ifosfamide/CDP(IFO 6g/m2/CDP 100mg/m2) and IFO/ADM (IFO 6g/m2/ADM 60mg/m2) were repeated three times (9 cycles). Surgery was planned after 3 cycles. Methotrexate (8g/m2) was postoperatively added in poor responders. Immediate surgery was allowed and 9 cycles with CDP, ADM, IFO were postoperatively given.

At December 2007, 140 patients were registered (median age 51 years). OS (51%), S (16%), and DCh (11%) were the more frequent histotypes. Synchronous metastases in 30 (21%) patients, central location of tumor in 45(32%).Surgical complete remission (SCR) was achieved in 84% of patients, (localized 91%, meta-static 37%) without difference among the histology groups. One surgical-related and one chemotherapy-related death were reported.

Grade4 WBC and PLT incidence was 55% and 17%.Renal toxicity and peripheral neurotoxicity were reported in 16% and 20% of patients. With a median follow-up of 25 months (4–68) 3 year OS was 58% (95%CI 48–68%) [7% (95%CI 0–19%) without SCR]. In patients with SCR, 3-year OS and EFS were 46% (95%CI 9–83%) and 0% in case of synchronous metastases and 69% (95%CI58–80%) and 45% (95%CI33–57%) for localized patients; 50% (95%CI 29–71%) and 40% (95%CI 20–59%) for patients with central tumor, 73% (95%CI61–85%) and 44% (95%CI31–57%) for those with extremity tumor; 68% (95%CI 52–83%) and 46% (95%CI 32–54%) for OS, 64% (95%CI 42–85%) and 48% (95%CI 25–71%) for S, 48% (95%CI 13–82%) and 27% (95%CI 1–54%) for DCh.

The protocol is feasible, but the chemotherapy-related toxicity is remarkable. Surgical complete remission is the main factor influencing survival. Central location and synchronous metastases are negative prognostic factors, but 50% 3-year OS can be achieved with aggressive local and systemic treatment. Osteosarcoma and high-grade sarcoma NOS benefit from chemotherapy more than patients with dedifferentiated chondrosarcoma.


C. Moquin-Pattey

Investigator-Driven Clinical Trials (IDCT) form a key part of patient-oriented clinical research, the basis for continually improving patient care. Such research is under strain in Europe for a multiplicity of reasons, and because of this the European Medical Research Councils (EMRC) of the ESF has undertaken in 2007 a Forward Look exercise. This Forward Look represents what is probably the most comprehensive examination of IDCT in Europe in recent years. A thorough analysis of the problems faced by academic investigators conducting IDCT was carried out through a series of workshops covering different themes and attended by active and acknowledged experts in the field. These workshops identified specific issues that need to be addressed:

- Categories and Design of Investigator-Driven Clinical Trials

- Regulatory and Legal Issues, Intellectual Property Rights and Data Sharing

- Management of Investigator-Driven Clinical Trials

- Education, Training, Career Tracks and Authorship

- Funding and Models of Partnership

- Status of Investigator-Driven Clinical Trials in Central and Eastern European Countries

A range of possible solutions were proposed and five among the 26 recommendations as ranked by the consensus conference, held on 29–30 September 2008, were considered as top priorities to strengthen IDCT in Europe:

To improve the education, training and career structure for scientists involved in patient-oriented clinical research.

To increase levels of funding for IDCT.

To adopt a ‘risk-based’ approach to the regulation of IDCT.

To streamline procedures for obtaining authorisation for IDCT.

To ensure that IDCT are carried out with an appropriate number of patients to produce statistically reliable results – that the trials are ‘correctly powered’.

To help implement the recommendations expressed in the report for strengthening patient oriented research in Europe a broad dissemination to the four stakeholder groups identified as key players will be assured.We clearly think that if we can collaborate on this important issue and improve conditions for clinical research, we can contribute to bringing better health and prosperity to Europe.


J. Demotes-Mainard

Clinical research needs distributed infrastructures: efficient patient recruitment is a major bottleneck to clinical research, whereas quality of investigation, credibility of data, and compliance with regulation require professionalized support. The European Clinical Research Infrastructures Network (ECRIN) is designed to support multinational clinical research in the European Union. It is based on the connection of national hubs, each coordinating a national network of generic clinical research centres or of disease-oriented networks. Supported by the European Commission (FP7 Infrastructure programme) as an ESFRI roadmap infrastructure, it promotes multinational collaboration within the European Union, taking advantage of the EU population size and unlocking latent scientific potential.

Building such a distributed, pan-European infrastructure requires addressing the challenge raised by the fragmentation of health and legislative systems. Networking of national clinical research infrastructures led to the development of common standards, of harmonised tools and practice. In addition, ECRIN provides integrated, ‘one-stop shop’ services to investigators and sponsors in multinational studies: patient recruitment and investigation, quality assurance, monitoring, ethical and regulatory requirements, adverse event reporting, circulation of medicinal products and of blood and tissue samples, data management. Information and consulting also help investigators prepare their study: ethical and regulatory requirement, insurance, centre selection, cost evaluation, funding opportunities. Access is given to users (mostly investigators and sponsors in the academic institutions that often lack the capacity to act as a sponsor in the conduct of EU-wide studies) after assessment of the protocol by the scientific board. Services provided by ECRIN are particularly relevant for research on rare diseases and neglected diseases, for clinical trials in elderly and paediatric populations, for academic clinical research institutions, and for clinical trials steered by biotechnology SMEs.


A. Parafioriti S. Del Bianco E. Armiraglio P.A. Daolio S. Mapelli

Epithelioid hemangioendothelioma (EHE) is a rare vaso-formative tumor of variable biological behavior that has been considered a tumor of borderline malignancy and low-grade angiosarcoma. The majority of cases are associated with low mortality, but some metastasize and cause patient death. Its principal sites of occurrence are soft tissues, liver, lung, and bone. EHE develops as a solitary, painful mass in superficial or deep soft tissue of the extremities and it generally arises from a vessel. Cytogenetic findings are very limited and comprises three reports on totally 4 cases, describing translocations between chromosomes 1 and 3 in two cases, chromosomes 7 and 22 in one case and chromosome 10 and 14 in the last case.

We characterized immunohistochemically 5 cases of this tumour type and currently we are performing Real-Time PCR assays to analyze the expression of two genes (MDM2 and CDK4) known to be involved in pathogenesis of tumours.

Three out 5 patients presented epithelioid hemangioendothelioma of the bone while two affected soft tissues. All the samples showed positivity for CD34 and CD31; 4 samples out 5 were also positive for FLI1. We tested Factor VIII immunostaining on 3 of these cases which resulted positive; EMA was positive on 3 samples out 5. Cytocheratins (AE1/AE3, CAM 5.2 and CK7) were always negative except in one case which showed CAM 5.2 positivity. Our preliminary results by Real-Time PCR analysis performed on 5 cases suggest that MDM2 and CDK4 have a different expression in epithelioid hemangioendotheliomas compared to normal tissue.

Our study shows that use of molecular techniques such as Real-Time PCR could complement histopathological diagnosis in order to identify a marker of biologic behaviour of this enigmatic tumour type.


Judith V.M.G. Bovée

Over the years, the terminology and classification of vascular tumors of bone has been highly controversial and in literature a great variety of names has been proposed. The large variety of entities of vascular tumors of bone suggests that it should be regarded as a spectrum with on one side the overtly benign lesions and on the other side the frankly malignant lesions. In between there is the intermediate category in which numerous histomorphological diversity can be seen and for which classification is most difficult. Benign vascular lesions of bone (solitary haemangiomas) at the one end of the spectrum, are relatively common and occur most frequent as an asymptomatic incidental finding in the skull or spine, although extraspinal locations are also reported. At the other end of the spectrum, primary malignant vascular tumors of bone are rare, representing less than 1% of primary malignant bone tumors.

Angiosarcoma is the most acceptable term for high-grade malignant vascular tumors of bone, which is highly aggressive with an ominous prognosis. The classification of the intermediate category of vascular tumors of bone, in particular of so-called haemangioendotheliomas, is extremely difficult due to the lack of uniform terminology and accepted histological criteria. Many authors have proposed different classification systems, but due to small numbers of cases, their large diversity and the lack of good correlation with clinical outcome none of them have been generally accepted so far. Within this intermediate category, epithelioid hemangioendothelioma is a separate and well recognized entity with morphological features exactly similar to its soft tissue counterpart, and is often multifocal.

Epithelioid hemangioma is a recently described entity characterized by a moderately differentiated, lobulated proliferation of epithelioid endothelial cells. The lesion can be multifocal, and behaves in a benign fashion although local recurrence (8%) and spread to the lymph nodes (2%) may occur. There is considerable overlap with the entity previously described as haemangioendothelioma of bone which has variable histological patterns and no distinguishing histological features could be proposed. Moreover, the entity hemangioendothelioma of bone may not only overlap with epithelioid hemangioma of bone, but also with the rare low grade angiosarcoma of bone. Therefore, there is increasing evidence that haemangioendothelioma of bone seems to represent two different entities and the use of this term should be avoided.


M. Alberghini P. Ruggieri A. Angelini G. Ussia M. Gambarotti C. Ferrari D. Vanel P. Picci M. Mercuri

Forty-six hemangioendotheliomas (HE) of bone treated at Rizzoli from 1985 to 2004 were studied with minimum follow up of 4 years: 19 females and 27 males, mean age 37 years, mean follow-up 9 years, 35 cases unifocal at diagnosis (10 spine – 1 with lung metastasis also- 11 lower limb, 8 upper limb, 6 pelvis) and 11 with multifocal involvement. In 10 patients intralesional surgery was previously performed elsewhere. In 27 patients primarily treated at Rizzoli with unifocal localization, surgery was used in 15 cases, surgery and radiotherapy in 7, surgery with radio/chemotherapy in 1 and no surgery in 4 (2 radiotherapy, 1 radio/chemotherapy and 1 embolization). Eight unifocal patients already treated elsewhere had surgery in 3 cases, surgery and radiotherapy in 3, surgery with radio/chemotherapy in 1 and surgery plus chemotherapy in 1. Three of the unifocal cases had further bone involvement subsequently. Nine multifocal patients primarily treated at Rizzoli had surgery in 4 cases, surgery and radiotherapy in 4, surgery with radio/chemotherapy in 1. The 2 previously treated multifocal HE had 1 surgery and 1 radiotherapy.

Six patients died: 3 of disease, 1 of radio-induced osteosarcoma, 2 of different disease. Two patients are AWD. Of remaining 40 patients, 26 are NED (mean follow up 9 years), 11 NED after treatment of recurrence, 1 NED after treatment of radio-induced sarcoma. No lung metastases were diagnosed after treatment. All 10 cases previously treated intralesionally had recurrence. Two of 15 unifocal cases treated with surgery recurred (13%). None of 9 resected unifocal cases previously untreated recurred. Two of 21 pts. with radiotherapy (9.5%) had radio-induced sarcoma.

Surgery is recommended, resection when feasible. Radiotherapy, implying risk of induced sarcoma, should be reserved to multifocal or unresectable cases. Adverse prognostic factor was previous intralesional surgery.


J. Bruns

Clear cell sarcoma (CCS) is a rare and highly malignant soft-tissue sarcoma (STS) constituting 1% of all STS. It most often appears in the soft tissue closely assocíated with tendons, aponeuroses or fascial tissue of the distal extremities. It shares features of melanomas, hence is dubbed as a soft-tissue melanoma or clear cell sarcoma of the tendons and aponeuroses (CCSTA). CCS differs from the more common STS by its more aggressive growth and greater propensity to metastasise to lymph nodes, bones and lung. On a molecular basis, CCS is characterised by the chromosomal translocation.

Clinically, the tumor is firm, slowly growing and painless in half of the cases, thus rarely awakening suspicion of a STS. Thus, the diagnosis is difficult. Furthermore, on an MRI the tumor exhibits mostly a homogenous mass with a higher signal intensity as compared to muscle on T1-weighted images and implies a benign tumor.

The most important treatment is a wide resection to ensure local control. Little is known about neo- and/or adjuvant chemotherapy or radiation. Regarding chemotherapy different substances (doxorubicin, ifosfamide, cisplatin, mesna, dacarbazine, cyclophosphamide) have been administered under different conditions (single or combined substances, different doses, neo- or adjuvant). There are also some reports displaying the advantages of caffeine-assisted chemotherapy.

Under similar different circumstances radiation therapy was applied.

Most important prognostic factors are the presence of tumor necroses, size and regional lymph node metastases, local recurrence and distant metastases.

The reported 5-year survival ranges from 48% to 68%, the 10-year survival from 36% to 41%. Summarising all reports there is a need at least for a retrospective study to gather information about more patients.


S.L.J. Verbeke F. Bertoni P. Bacchini R. Sciot H.M.H. Kroon P.C.W. Hogendoorn J.V.M.G. Bovée

High-grade angiosarcomas (HGAS) of bone are rare and represent less than 1% of the primary malignant bone tumours. Because of their rareness little is known. Clinically, it is accepted that they are extremely aggressive. Due to the lack of uniform terminology and accepted histological criteria, terminology and classification of primary malignant vascular tumours of bone has been highly controversial. Today, angiosarcoma is the most accepted term for high-grade primary vascular tumour of bone, recognized by the 2002 WHO Classification. However, distinct histological hallmarks to define a HGAS of bone are not clear.

We collected 64 HGAS of bone diagnosed between 1964 and 2007 from the files of the departments of pathology, Leiden University Medical Center (Leiden), Rizzoli Institute (Bologna) and University Hospitals (Leuven). All clinical, radiological, and pathological data were reviewed and different histological criteria were scored. A tissue micro-array was constructed containing 57 HGAS of bone. To confirm the vascular origin of all lesions and to investigate the diagnostic value of commonly used markers, immunohistochemistry was performed for CD31, CD34, Factor VIII, and keratin AE1/AE3. Staining was evaluated positive or negative.

Among 64 patients with HGAS of bone, there are 41 males and 23 females. There is a wide age distribution, with a nearly equal distribution from the second to the sixth decade. The solitary cases are mostly located in the extremities (66%) followed by trunk (12.8%), axial/central location (10.6%) and pelvis (10.6%). 17 cases (73%) have multifocal bone lesions. HGAS of bone show variable histological patterns. Association with clinical outcome (chi-square test) reveals that there is a significant poor survival when the tumour has tree or more mitoses (p=0.001), a macronucleoli (p=0.011) or there is an absence of an eosinophilic infiltrate (p=0.023). The HGAS of bone are positive for CD31 in 53/55 (96%), CD34 in 33/57 (58%), Factor VIII in 47/55 (86%), and keratin in 40/57 (70%). Only 15 out of 40 (38%) keratin positive angiosarcomas, showed an epithelioid phenotype at classical morphology. All tumours with an epithelioid phenotype are keratin positive.

Although HGAS of bone in general have a poor outcome, histological criteria such as three or more mitoses, the presence of a macronucleolus and the absence of an eosinophilic infiltrate can be useful to predict a more aggressive course, consistent with the clinical behaviour of a high-grade angiosarcoma. CD31 and Factor VIII are the best diagnostic markers for HGAS of bone. It is striking that keratin positivity is seen in the majority of cases, and is independent of epithelioid morphology. Pathologists should be aware of this to avoid misinterpretation as metastatic carcinoma.


S.H.M. Verdegaal J.V.M.G. Bovée T.C. Pansuriya R.J. Grimer B. Toker P.C. Jutte M. San Julian D.J. Biau I.C.M. van der Geest A. Leithner A. Streitburger F.M. Lenke F.G. Gouin D.A. Campanacci P.C.W. Hogendoorn A.H.M. Taminiau

Enchondromatosis is a non-hereditary disease, characterised by the presence of multiple enchondromas. While Ollier Disease is typified by multiple enchondromas, in Maffucci Syndrome they are combined with haemangioma.

Due to the rarity of these diseases, systematic studies on clinical behaviour providing information how to treat patients are lacking.

This study intends to answer the following questions: What are predictive factors for developing chondrosarcoma? When is extensive surgery necessary? How often patients die due to dedifferentiation or metastasis?

Twelve institutes in eight countries participated in this descriptive retrospective EMSOS-study. 118 Patients with Ollier Disease and 15 patients with Maffucci Syndrome were included. Unilateral localization of disease was found in 60% of Ollier patients and 40% of patients with Maffucci Syndrome.

One of the predictive factors for developing chondrosarcoma is the location of the enchondromas; the risk increases especially when enchondromas are located in the scapula (33%), humerus (18%), pelvis (26%) or femur (15%). For the phalanges, this risk is 14% in the hand and 16% in the feet. The decision whether or not to perform extensive surgery is difficult, especially in patients who suffer multiple chondrosarcomas.

Malignant transformation was found in fourty-four patients with Ollier Disease (37%) and eight patients with Maffucci Syndrome (53%). Multiple synchronous or metachronous chondrosarcomas were found in 15 patients.

Nine patients died (range 21–54 yrs). Seven of them died disease related due to pulmonary metastasis (2 humerus, 2 pelvis, 3 femur). Two patients died from glioma of the brain.

In conclusion, one important predictive factor for developing chondrosarcoma is the location of the enchondromas; interestingly, only patients with chondrosarcoma outside the small bones died of their disease. In this series, no dedifferentiation of chondrosarcoma was seen. A first design flow-chart how to approach chondrosarcoma in patients with Ollier Disease and Maffucci Syndrome is in preparation.


M. Balke A. Neumann K. Agelopoulos E. Korsching J. Hardes C. Kersting H. Buerger G. Gosheger M. Hagedorn

Because of the lack of a suitable in vivo model for giant cell tumors of bone little is known about their biological behavior and mechanisms of metastasis. No existing cell line contains all tumor components, so that testing of anti tumor agents is hardly possible. We therefore modified the chick chorio-allantoic membrane (CAM) assay for giant cell tumor of bone (GCTB).

Out of tumor tissue obtained during surgery of 5 patients a solution was produced. The solute was grafted onto the CAM at day 10 of embryonic development. The growth process was monitored by daily observation and photo documentation using in vivo microscopy. After 5 to 6 days of tumor growth the samples were fixed in formalin and further analyzed using standard histology (hematoxylin and eosin stains).

The tissue solute of all 5 patients formed solid tumors when grafted to the CAM. In vivo microscopy and standard histology revealed a rich vascularisation of the tumors. The tumors were composed of the typical components of GCTB including multinuclear giant cells.

A reliable protocol for grafting of human giant cell tumors onto the chick chorio-allantoic membrane was established. This model is the first in vivo model for giant cell tumors of bone. Further characterization of the growing tissue is necessary in further experiments.


C.R. Galia C.A.S. Macedo R. Rosito C.V. Diesel V. Penna R.G. Becker C.A. Pinheiro E.A. Toller

Gorham syndrome is a rare disease of unknown cause. It is characterized by the massive bone destruction associated to bone angiomatosis. It was first described by Jackson in 1838. Gorham and Stout published their initial report in the fifth decade of the last century. The diagnosis depends on the exclusion of other diseases that cause bone lysis. The treatment has no uniformity between the oncologists, and different modalities of therapeutic procedures are being used as radiotherapy, biphosphonates, interferon and surgery.

This case reports a man, 44 years old, caucasian farmer that had a progressive pain in the left groin one year ago. The pain was getting worst and migrated to the left hip. A pelvis X-ray revealed isquiatic lysis with total disappearing of the bone. The left hip presented diffuse lytic areas too. The clinical profile of the patient was good and it was discrepant when compared to the X-rays with bone destruction.The investigation was done with bone scintilography, MRI of the pelvis, computed tomography (CT) of abdomen and chest, blood analysis of PTH, calcium, phosphate, eletrophoresis of proteins, PCR, hepatic function, and two consecutive bone biopsies of the left hip and pelvis. All exams excluded metastatic or primary bone tumors. A multi-disciplinary team of clinical oncologists, endocrinologists, nephrologists excluded other neoplastic, metabolic and rare diseases as Hadju and Cheney acro-osteolysis, carpal and tarsal osteolysis, multicentric osteolysis with nephropaty, hereditary multicentric osteolysis, Joseph acro-osteolysis, Shinz acro-osteolysis, Faber disease and Winchester disease. A multidisciplinary meeting decided by the orthopaedic surgery and radiotherapy to relieve the pain and to achieve the pathological diagnosis. The girdlestone surgery was done and the histopathological analysis showed diffuse angiomatosis in the specimen, diagnosing Gorham syndrome.

Gorham syndrome diagnosis depends on a tripod: clinical exclusion of other pathologys, image investigation and histopathology diagnosis. All three characteristics are primordial to the diagnosis of this pathology and a full investigation in a multidisciplinary level is necessary.


P. Ruggieri M. Alberghini M. Montalti C. N. Abati L. Zanella D. Vanel M. Mercuri

Gorham-Stout disease (GSD) is rare, characterized by proliferation of vascular channels resulting in progressive distruction of bone. In the Rizzoli files we found 15 cases of GSD from 1968 to 2008. Two were excluded for insufficient documentation. For 13 cases clinical data, imaging and histology were analysed. Histopathologic features included benign vascular proliferation, vascular pattern of osteolytic angioma, fibro-connective tissue component and bony destruction. A final diagnosis was established based on clinical, radiological and histopathologic features.

Imaging included X-rays in 11 cases and CT or MRI in 5. All lesions were lytic, with associated sclerosis in two cases. There was one lesion only in 4 cases, multiple lesions in the same bone in 1 and multiple bones involved in 6. Primary sites were proximal femur in 7 cases, pelvis in 2, hip and knee, calcaneus, humerus and cervical spine in 1 case each. Two patients had no treatment, 2 conservative treatment (cast or brace), 5 surgery, 6 medical treatment (byphosphonates, calcitonin, zoledronic acid, interferon, steroids), 1 radiotherapy, 2 selective arterial embolization. Surgery consisted of internal fixation of pathologic fractures in 4 patients and reconstruction of the entire humerus with a double composite allograft in 1. Treatment was surgery only in 2 patients, medical treatment in 4 (1 also embolization), surgery and medical treatment in 2 (1 also embolization), radiotherapy only in 1, conservative treatment in 2. Four patients were lost at follow up. Mean follow up was 17 ys.(min 2, max 30) in 9 patients: 2 dead, 3 healed, 3 with stable disease, 1 alive with disease at 24 ys.

No conclusive treatment recommendations are possible; surgery is indicated in pathologic fractures or reconstruction of massively destroyed bones, medical treatment and selective embolization are helpful. In literature prosthetic reconstruction is preferred due to the risk of allografts resorption.


CLMH Gibbons F. Jones R. Taylor H. Knowles P Hogendoorn JAH Wass M Balke3 C Gebert3 N A Athanasou

Giant cell tumour of bone (GCTB) is an expansile osteolytic tumour of bone which contains numerous osteoclast-like giant cells. GCTB is a locally aggressive tumour which can cause extensive bone destruction that can be difficult to control surgically, up to 35% of cases recurring after simple curettage. Bisphosphonates are anti-resorptive agents that have proved effective in the treatment of a number of osteolytic conditions.

In keeping with its known effect on osteoclasts, we found that the aminobisphosphonate zoledronate abolished in vitro lacunar resorption in cultures of osteoclasts isolated from GCTB. The effect of zoledronate and other bisphosphonates on 15 cases of recurrent primary GCTB, four of which had metastasised to the lung, was assessed clinically. Most recurrent tumours did not exhibit progressive enlargement and, in some cases, both primary and metastatic GCTBs showed a degree of radiological improvement following treatment However, tumours did not diminish in size and, in some cases, no apparent treatment effect was noted.

Our findings provide in vitro evidence for the use of bisphosphonates to inhibit the progressive osteolysis associated with GCTB. In vivo, these agents produced a degree of clinical and radiological improvement in some cases. This study reports results from three European centres where bisphosphonates are being used to treat recurrent GCTB and highlights the fact that these centres are all employing different clinical indications and different regimes of bisphosphonate treatment. Bisphosphonates have significant side effects and indications for treatment and standardisation of drug type and dosage regimes (and measurement of agreed outcome measures to determine treatment efficacy) should be established before these agents are included as part of a treatment protocol to control GCTB tumour growth and osteolysis.


P. Daolio S. Bastoni R. Zorzi F. Lazzaro P. Zacconi A. Parafioriti R. Bergamaschi S. Mapelli

EH of bone is a rare vascular neoplasm, subtype of hemangioendothelioma, characterized by mesenchimal cells that have an epithelioid endothelial appearance. There are different kinds of EH: the benign epithelioid hemangioma, and the malignant epithelioid angiosarcoma.

This tumors can occurs in soft tissue, lung, liver and bones and often are multicentric.

EH generally involve the bone of the spine and lower limb and is very rare in the upper limb and the hands. The main symptom is pain; pathological fracture may occur in aggressive lesions.

Radiographically the EH is a ostelytic lesion with variable peripheral sclerosis, cortical destruction and periosteal new bone.

Treatment of EH is curettage and local adjuvants in benign lesion, en bloc resection in the low-grade forms and wide or radical surgery in the high-grade forms. Radiation therapy is suggest in inoperable situations.

In the present report we describe the clinical features, the oncological treatment and the reconstructive solutions of two cases of EH of the hand treated in the Orthopedic Oncological Center of Gaetano Pini Institute of Milan. Both cases had multiple locations in the carpus, metacarpus and phalanges. The involvement of more joints caused a delayed diagnosis (> 1 year). Exer-esi and reconstruction of several segments of the wrist and hand has led to considerable technical difficulties resolved with the collaboration of the microsurgeon and plastic surgeon.


K. Pfeifenberger A. Leithner W. Maurer-Ertl A. Beham R. Windhager

Epitheloid haemangioendothelioma is a rare tumour of vascular origin. It is characterised by the appearance of epitheloid endothelial cells and occurs typically in soft-tissue, skin, and liver. Less frequently it is found in bone. The tumour is more often located in the long bones of the lower extremities, and the pelvis than in the upper extremities, vertebral column, and flat bones. The lesion nearly affects all age groups and there is a male predilection.

Case 1: A 71-year old woman had pain in the area of her right hip after a downfall. X-ray showed a lucency of the cortical substance of the right femur. Scintigraphy showed a cortical lesion, oedema of the bone-marrow and an involvement of soft-tissue. Carcinoembryonic antigen, CD 31, and CD 8 were positive. An open biopsy verified an epitheloid haemangioendothelioma. Staging was negative. A wide resection of the proximal femur and reconstruction with a tumour-prosthesis were performed. Four months later the patient had osteolytic metastases of os ilium, os pubis, acetabulum and in the fifth lumbar vertebra. The patient died 8 months after the wide resection of the tumour because of myocardial infarction.

Case 2: An epitheloid haemangioendothelioma of the liver was diagnosed in a 21-year old male patient. Twelve years after the primary tumour the patient had osteolyses of the first cervical vertebra, manubrium sterni, and ribs. An open biopsy verified the metastatic spread. Local radiotherapy was performed. Furthermore the patient developed a destruction of processus spinosus and a pathologic fracture of first thoracic vertebra. The patient died of metastatic disease 2 years later or 14 years after the initial diagnosis.

Epitheloid haemangioendothelioma of bone is a rare tumour and the diagnosis is quite difficult. Metastatic rate is about 20–30% and mortality about 10–20%. As presented in our cases bone involvement could either be attributed to primary haemangioendotheliomas of bone or to metastases of non-osseous forms. As in our cases it has been reported, that predicting prognosis is difcult, however nuclear atypia, mitotic activity, spindling of cells, and necrosis have been reported as negative prognostic factors.


M. A. G. Sousa D. Freitas M. Massada C. Santos P. Cardoso

Intramuscular hemangyomas are benign tumours (0,8% of all hemangyomas). Their aetiology is uncertain but they are possibly congenital, although some seem to be related to trauma. Symptoms (usually pain and swelling) may be present for years. Histological subtypes are cavernous, capillary and mixed. Optimal management includes precise diagnosis and wide excision to prevent local recurrence.

Authors present a case of a 79 years male with cavernous hemangyoma of the thigh with three years of evolution. The tumour eroded the femur and the patient had a mass all over the thigh with tension and pain. Diagnosis was suspected by phleboliths seen on x-ray and MRI and was confirmed by open biopsy.

Treatment was a complete excision with double approach, medial and lateral, plus prophylactic nailing of the femur.

With a four years follow – up, the patient has no sign of recurrence and has a normal function of the inferior limb and a normal gait.


E.L. Staals M. Nogales M. Alberghini M. Gambarotti M. Mercuri

Solitary fibrous tumour (SFT) is a relatively uncommon mesenchymal neoplasm that most frequently arises in the pleura, but is also known to affect extrathoracic sites. About 15 % of SFT’s behave in an aggressive way, giving rise to local recurrence and/or distant metastasis. However, the behaviour of SFT remains unpredictable and due to the rarity of this tumour, it is difficult to define prognostic factors. The purpose of this study was to describe our experience with SFT, trying to define the pathologic features of this rare entity and better understand its clinical behaviour.

We performed a clinicopathologic review of all cases treated for a SFT at the Istituto Ortopedico Rizzoli in Bologna, between 1996 and 2008. We included 24 patients, nine males and fifteen females, ranging in age from 22 to 82 years (median 43.5 years). The anatomical sites involved were: the thigh (12 cases), shoulder region (four cases), gluteus (three cases), foot (two cases), extrapleural thoracic wall (two cases), and the lower leg (one case).

The tumour was > 5 cm in 15 cases, ranging in diameter from 2.5 cm to 18 cm (median 7.5 cm). Pain and swelling were the most frequently reported symptoms at presentation, with a mean duration of symptoms of 10 months. All patients were treated by excisional surgery (wide margins in 11, marginal margins in 13). Three patients had undergone pre-operative radiotherapy (44Gy) and one of these had also adjuvant radiotherapy after marginal excision of the tumour. Six tumours showed at least one atypical histologic feature (moderate to marked cytological atypia, extensive tumor necrosis, ≥ four mitoses per ten high-power fields, or infiltrative margins). On immunohistochemistry, 21 cases were positive for CD-34, 10 for CD-99, 17 for vimentin, three for CD-31, four for actin and one for S-100. Subsequent follow-up (average 33 months, range 5 to 112 months) revealed tumour relapse in only one case: a bone metastasis after 36 months of follow-up. The initial lesion was considered a large, deep, malignant SFT of the thigh, treated with wide surgical excision.

In the current review, including 24 extrathoracic solitary fibrous tumours, all lesions but one had a benign course. Nevertheless, this entity has a potential to recur or metastasize, and therefore careful long-term follow-up is necessary for all patients, even after wide excisional surgery. Although specific prognostic factors are yet to be defined, a high degree of suspicion for malignant behaviour is warranted for those cases in which atypical histologic features are present, particularly in the context of a deep tumor > 5cm in diameter.


S. Ash L. Kachko J. Katz M. Mukamel D. Weigel L. Kornreich M. Feinmesser I. Yaniv

Hemangioendothelioma is a rare vascular tumor that is infrequently recognized in bone. It can be multicentric and often painful with an indolent course. The treatments of choice include curettage, resection, radiation, systemic medications or a combination of these modalities.

O.G. 5 years old girl, presented with left ankle pain and limping, without response to non steroidal anti-inflammatory drugs for few months. Radiological investigation (MRI) showed a lytic vascular lesion in the methadiaphysis, invading the epiphysis of the distal left tibia and lateral cartilage of the ankle, with atrophy of the left lower limb. Bone scan showed high uptake in this area. Histology showed fragments of bone, infiltrated by a vascular lesion with nodular pattern, well differentiated vascular spaces and endothelial cells with few mitotic figures. Immunostains were positive for CD31 and F8. The pathology report confirmed hemangioendothelioma.

As the lesion invaded the growth plate of the distal tibia, surgical or radiation therapy at this age could cause a permanent damage. We therefore successfully treated the child with Interferon α–2β 0.5 million IU three times a week for 18 months. She was pain free after the first few months of therapy with full recovery of daily function and activity. Radiological evaluation showed improvement on X-ray and MRI, and shrinkage of the lesion to the epiphysis area only.

Unfortunately, 3 years later the pain and limping reappeared. MRI showed a lytic lesion in the diamethaphysis of the left tibia. Re-biopsy supported the diagnosis of recurrent hemangioendothelioma. She was retreated with Interferon α–2β using the same protocol with considerable improvement of the pain and limping.

We present here a non invasive option for therapy with Interferon α–2β for bony lesion of hemangioendothelioma that enable us to spare the growth plate in a growing prepubertal child.


J. Rössler M. Lauten C. Martini J. E. Otten S. Knöller M. Uhl M. Henschen C. M. Niemeyer

Vascular anomalies with skeletal involvement are rare. To ameliorate diagnostics and therapy the classification of the International Society for the Study on Vascular Anomalies (ISSVA) should be applied where proliferating vascular tumours are separated from malformations, which are hereditary and do not change. Furthermore, blood and lymph vessel lesions are distinguished. In addition to isolated local or multifocal bone lesions, involvement of soft tissue and/or other organs can be observed.

Here, we report on 6 patients with lymphangiomatosis. Diagnostic workup using whole body MRI is most sensitive to detect all lesions. Localisation was the mandible (n=2), spinal column (n=4), femur (n=1), tibia (n=1), pelvis (n=1), humerus (n=1), scapula (n=1) and rips (n=1). Soft tissue involvement was observed in all patients, 1 patient showed additional lesions in the kidney and spleen, 3 patients in the lung. These 3 patients could be diagnosed with Gorham’s disease, a potentially lethal form of skeletal lymphangiomatosis, with thoracic involvement.

Next to the difficulty to find the correct diagnosis, therapy is not standardized. A major problem is the treatment of Gorham’s disease. In the literature, case reports on surgery as well as interferon alpha, chemotherapy, bisphosphonates and radiation therapy can be found. We performed surgery (n=2), radiotherapy (n= 1), polychemotherapy (n=1), bisphosphonates (n=2) and conservative therapy (n=3). One of the patients with Gorham’s disease died because of progressing pulmonary insufficiency.

It is still unclear if prophylactic therapy for skeletal involvement should be administered and which therapy is effective. An international register and a multicenter clinical trial are urgently needed.


F. Sinnaeve R.J. Grimer S.R. Carter R.M. Tillman A. Abudu L. Jeys

Disappearing bone disease is also known as vanishing bone disease, phantom bone disease, massive osteolysis, Gorham’s disease or Gorham-Stout disease. Basically, it is characterised by osteolysis in (contiguous) bone segments, due to localised proliferation of thin-walled vascular channels in the bone and surrounding soft tissues.

The etiology and pathophysiology of this condition remain poorly understood and largely unclear, but there is increasing evidence that disordered lymphangiogenesis plays a role. It is an extremely rare cause of osteolysis, so all other differential diagnoses should be considered and ruled out before retaining the diagnosis of disappearing bone disease.

Treatment is fairly disappointing and no single treatment modality has proven effective in actually arresting the disease. Conservative treatment includes ant-resorptive agents (bisphosphonates), immunomodulating substances and radiation therapy, whereas surgical treatment options include resection and reconstruction with bone grafts and/or prostheses versus amputation.

We report on the only two cases that were identified in our database between 1984 and 2008, both affecting the lower limb (one tibia, one femur). In an attempt to limb salvage, these patients initially underwent endoprosthetic replacement of the affected bone segment, but due to disease progression both eventually ended up with a hip disarticulation.

Conclusion: Although benign, this condition can be very aggressive, necessitating amputation to achieve local control.


M. Hiz S. Ustundag T. Aksu S. Dervisoglu N.M. Mandel F. Dincbas

Haemangioendothelioma of bone is a rare intermediate grade malignancy. Because of its rareness there is a lack of information in the literature about the well established treatment strategies depending on series with large numbers. The outcome of wide resection with postoperative external irradiation would be presented.

4 patients (2 females, 2 males) with a mean age of 40.5 (26–52) with solitary haemangioendothelioma of bone admitted with local pain on the affected bone and limited restriction of function. Anatomical sites were scapula, calcaneum, midshaft of radius and metaphysodiaphyseal region of femur. Plain X-ray, CT, MRI, Tc 99 tecnetium wholebody bone scan investigations were applied. All lesions were hot on bone scan and lytic irregular permeative lesions T1 hypo, T2 hyper with gadolinium enhancement were present. Open biopsy resulted with the diagnosis of intermediate haemangioendothelioma of bone. Wide resection of tubular bones and intercalary lyophilised allograft recostruction with IM rod and cerclage wire and total calcaneum resection and allograft replacement with talar arthrodesis, total scapulectomy subsequent autoclaved bone reimplantation were the surgical procedures applied. Mean follow-up was 96 months (40–132). Three patients except scapula case received 50 Gy external irradiation. No patient developed local recurrence in the follow up. Regarding complications calcaneum patient developed skin necrosis after the irradiation which led to removal of the allograft but eventually healed. Scapula patient had late infection treated by antibiotics. All patients had satisfactory function. Intercalary allografts united in 6 months time. Calcaneum patient developed multiple small lung metastasis 1 year after the operation and treated by adriamycin based chemotherapy and interpherone. The lung lesions showed slight regression but the patient is alive since 112 months with no further relapse.

Wide excision with subsequent irradiation and wide excision of total scapula resulted with no local recurrence in our small group of patients with this rare malignancy. Irradiation provided relatively less soft tissue sacrification and a sufficient local tumour control without risking the patient to an impending amputation in the occurence of local recurrence.


S.L.J. Verbeke C.D.M. Fletcher P. Picci S. Daugaard H.M.H. Kroon P.C.W. Hogendoorn J.V.M.G. Bovée

Haemangiopericytoma (HPC) was first described by Murray and Stout as a soft tissue neoplasm with distinct morphologic features, presumably composed of pericytes. Over the years, it became clear that many tumours could mimic a HPC-like pattern. These days, it is accepted that in soft tissue most lesions diagnosed as HPC in the past are actually solitary fibrous tumours (SFT), synovial sarcomas (SS) or myofibromatoses. It has been unclear whether the very rare HPC of bone is atrue entity, or that the HPC-like vessels are non-specific and part of other, different entities.

We collected 10 primary HPC of bone from four institutions diagnosed between 1952 and 2002. All data were reviewed. Immunohistochemistry was performed for CD31, CD34, factor VIII, SMA, keratin AE1/AE3 and EMA. Staining was evaluated as focal positive, diffuse positive or negative.

There were five female and five male patients between 21 and 73 years of age (mean 45.3 y). All tumors were located within bone. The primary site of the tumour was the femur in two patients, humerus in one, fibula in one, sacrum in two and vertebra in three. All tumours showed the presence of prominent thin-walled branching vessels surrounded by more undifferentiated spindle or round cells. However these cells showed some variation in their morphologic pattern: five tumours showed a patternless architecture and varying cellularity, consistent with SFT. Three tumours showed more densely packed sheets of poorly differentiated cells, similar to SS, and one case each represented paraganglioma and PEComa, possibly metastatic. Tumours resembling SFT showed usually focal to diffuse staining for CD34. All tumours were negative for SMA. Two tumours more similar to SS showed focal positive staining for keratin AE1/AE3 or EMA (66%). Some tumours showed severe decalcification artefact. None of the 10 tumours show CD31 and factor VIII expression. FISH is performed to study SYT rearrangements.

Our retrospective review of tumours diagnosed as HPC of bone in the past revealed the absence of true pericytic differentiation and the existence of both SFT of bone and SS of bone. Therefore, as in soft tissue tumours, HPC-like features are non specific. Diffuse CD34 staining is helpful to diagnose SFT of bone, whereas keratin/EMA staining is suggestive for SS of bone.


Full Access
H. Ozger A. Kochai B. Alpan M. Sungur B. Toker L. Eralp

Aneurysmal bone cysts are benign lesions of bone that tend to recur if they display an aggressive behaviour. In this study, an aggressive lesion is described as one with almost completely lost cortices on standard x-rays, mimicking ‘vanishing bone disease’. Purpose of this study is to retrospectively analyse the treatment results in this special patient subgroup.

Sixteen patients with a mean age of 23.1 (6–44) were included in this study. Femur (%25) was the most commonly affected bone. Spinal lesions were excluded. All lesions were diagnosed by preoperative tru-cut biopsy, however open biopsy was also done if requested by the pathologist. All lesions were preoperatively examined by contrast enhanced MRI. They were evaluated as having almost no cortical bone rim but a periosteum like soft tissue envelope. Intraoperatively, following an extended curettage, this tissue was observed as an alive periosteal layer. Phenolisation was added and cavities were filled with allograft bone chips. The periosteum was sutured around the grafts. Additional stabilisation was performed by external fixator in 3 patients, dynamic compression hip screw in 1.

Patients were followed up for a mean period of 47.8 months (9–84). Lesions healed after a mean period of 28.2 weeks (6–126). There was recurrence in 5 patients. The number of additional procedures necessary for relapsed lesions was 3 for one patient, 2 for another patient and 1 for the remaining 2 patients. Time to healing was not included for 1 patient who refused surgery for relapse and another patient who recently underwent surgery for relapse. One patient healed with a deformity.

Aneurysmal bone cysts may present as highly aggressive local bone lesions. Even in such a subgroup, resection to prevent relapses seems an exaggerated procedure. Extended curretage and packing may yield satisfactory results, with acceptable recurrence rates.


U. Albertini R. Piana G.C. Gino E. Boux S. Marone M. Boffano A. Linari C. Faletti E.M. Brach del Prever

Giant cell tumor (GCT) of bone is an aggressive tumor with high rate of recurrence. Bad prognosis factors were inquired, without a definite identification: type of treatment, soft tissue invasion, high proliferation rate at histology, pathologic fracture.

From January 2000 to February 2008, 38 patients affected by GCT were treated in a regional reference centre, 17 male, mean age 32 (range 16–69, median 29); one patient had 2 localizations (tarsal bone and proximal tibia); 3 were recurrences previously treated in other hospitals. Seven cases were in upper limb, 1 case in the sacrum, 30 in lower limb (20 around the knee); fracture at presentation was present in 6 cases; bone aneurismal cyst (ABC) was associated in 4 cases. Five cases in stage 3 were treated by bone resection followed in 4 cases by allograft and/or prosthesis (no reconstruction in 1 proximal fibula excision); 33 cases were treated by curettage, local chemical (phenole) and mechanical adjuvants (burring), filling with bone grafts in 13 cases, cement in 8 cases, cement and allografts in subchondral area in 11 cases. The sacral lesion was only curetted.

Seven patients developed a local recurrence, in 2 patients twice, for a total of 9 recurrences (19% of treatments). Recurrences occurred in 2 proximal tibia, in 2 distal femurs, in 1 proximal femur, in 1 distal radius and in 1 proximal fibula. The first treatment was bone grafts in 3 cases (23% of recurrence), bone cement and grafts in 2 cases (18% of recurrence), cement in 1 case (12% of recurrence), resection in the proximal fibula with severe soft tissue invasion. Two patients with associated ABC developed a recurrence and two with fracture at presentation.

In this study, increased rate of recurrences occurred with pathologic fracture at presentation, soft tissue invasion and ABC association.


M. Alberghini K. Kliskey T. Krenacs P. Picci N. A. Athanasou

Giant cell tumour of bone (GCTB) is a primary tumour of bone characterised by a proliferation of mononuclear stromal cells and infiltrating macrophages and osteoclast-like giant cells. GCTB has a variable and unpredictable course and can produce metastatic lesions, mostly in the lungs, in up to 3% of cases. Whether these represent tumour implants rather than true neoplastic secondaries is uncertain. In this study, we analysed morphological and immunophenotypic features of primary GCTBs which metastasised to the lung as well as the metastatic lesions themselves in order to determine if these would provide a clue as to the mechanism of lung metastasis in GCTB.

17 cases of primary GCTB which metastasised to the lung and the lung metastases in these cases were obtained from IOR, Bologna. Morphologically, primary tumours showed variable features, often containing both giant cell-rich and mononuclear stromal cell-rich areas. Mononuclear cells showed frequent mitotic activity and a degree of nuclear pleomorphism; none of the tumours showed cytological features of malignancy. The tumours were highly vascular and frequently contained dilated thin-walled blood vessels and large areas of haemorrhage. GCTB lung metastases were generally small and contained osteoclast-like giant cells and mononuclear stromal cells which showed typical mitotic activity; cytologically, the metastatic tumours were relatively bland and showed little nuclear pleomorphism. Expression of HLA-DR (an allele of which has been associated with a more aggressive GCTB phenotype) and smooth muscle actin (SMA) was noted in stromal cells in primary and secondary GCTBs; frequently, the same pattern of SMA expression was seen in both primary and secondary lesions. Osteoclasts were vitronectin receptor+, CD14-HLA-DR- in both primary and secondary GCTBs.

Our findings indicate that mononuclear stromal cells in lung metastases of GCTB often recapitulate the immunophenotype of the primary tumours from which they derive. Taken with the morphological finding that many primary GCTBs are highly vascular and contain areas of haemorrhage, it is possible that the lung “secondaries” of GCTB more likely represent tumour implants than true neoplastic metastases.


V. Penna E. Babeto E. Toller R.G. Becker C.A. Pinheiro L. Pires M. Valsechi L. Kerr P. Peitl P. Rahal S. Morini

The giant cell tumor of bone (GCT) is a locally aggressive intraosseous neoplasm, with an uncertain biological behavior, constituted of giant multinuclear cells spread over tumoral tissue with a nucleus presenting the same features of the ovoid and fusiform cells forming its stroma. The local recurrence of GCT is often observed, mainly in the first three years after treatment, giving a rate of recurrence ranging in 20 to 50% of cases. Further aggravating the recurrence is the fact that after the relapse, the patient often also presents metastases in other organs.

The aim of this study was to identify and to characterize differentially expressed genes that can be used in the prognostic, treatment and understanding of this physiopathology. To identify novel genes differentially expressed in GCT, we have applied rapid subtractive hybridization (RaSH). Samples of GCT and normal tissues were obtained at Tumor Bank of Barretos Cancer Hospital. After RNA extraction and cDNA synthesis the samples were submitted to Rapid hybridization Subtraction (RaSH) methodology for subtractive libraries elaboration.

The RaSH subtractive libraries reveals the presence of 619 different clones including both normal and tumor tissues were identified. Of these, 450 in tumor sample and 169 in control tissue. Four biomarkers candidates were selected for validation: ZAK, KTN1, NEB, and ROCK1 genes, whose functions are, related to cell cycle checkpoint, transport of organelles, cytoskeletal matrix and cell adhesions. The validation of selected differentially expressed genes was performed using real time PCR. The putative molecular markers found in this work may help to find the basis for a molecular comprehension of GCT, thus improving diagnosis, treatment and outcome for patients with this tumor.


T. Fladischer M. Glehr G. Gruber M. Zacherl A. Leithner R. Windhager

Background: Desmoplastic fibroma (DF) of bone is a very infrequent non-metastasizing osseous tumour with local aggressive appearance. The tendency of local recurrence in published cases is high.

Case reports: We present the clinical and radiological data of a male (35 years) and a female (37years) patient suffering from desmoplastic fibroma. Although in literature spinal lesions are severity rare, in our database two lesions located in the spine (C6 and L4) were identified. The first disturbances have been variable: The lesion in C6 was an accidental finding due to a control examination of a thyroid-ca, whereas the relapse-tumour of the L4 induced lumbago and hypaesthesia of the left heel.

Due to the importance of the thyroid treatment it was decided to control the lesion in C6 in close intervals. The lumbar tumour was initially treated outside and the first relapse was marginal resected at our department 11 years after the first diagnosis. The bone alterations appeared radiographically lytic and cystic.

Discussion: The spine is an unusual location of desmoplastic fibroma which arises in 56% at the long tubular bones followed by the mandible. To our knowledge only a few cases are reported to be located in the spine. DF located spinal, is a very untypical tumour and initial symptoms can be very unequal. Due to this dissimilar symptoms and variable histological appearance the diagnosis can be tricky. At least marginal resection should be achieved because intraleasional resected lesions show a local recurrence of 43%.


M. Balke H. Ahrens A. Streitbuerger G. Koehler W. Winkelmann G. Gosheger J. Hardes

Although the recurrence rate of giant cell tumors of bone (GCTB) is relatively high exact data on treatment options for the recurrent cases is lacking. The possible surgical procedures range from repeated intralesional curettage to wide resection.

214 patients with histologically certified GCTB have been treated at the authors department from 1980 to 2007. 67 patients with at least one local recurrence were included in this study. The mean follow-up was 77.3 months. The data was evaluated according the re-recurrence rate with regard to the surgical procedure for the recurrence.

The mean time until the first local recurrence was 22.0 months; the mean number of recurrences per patient was 1.4. The recurrence occurred in 69.7 % (46 out of 66 patients) within the first two years. If after intralesional procedures (curettage or intralesional resection) no adjunct was used the re-recurrence rate was 58.8 % (10 out of 17 patients) and decreased to 21.7 % (5 out of 23 patients) if a combination of all adjuncts (PMMA + burring) was used. The likelihood of re-recurrence was reduced by the factor 5.508 which was clearly significant (p = 0.016). In case of wide resection no re-recurrence occurred. Seven patients (10.5 %) developed pulmonary metastases. Fourteen patients (20.9 %) finally received an endoprosthesis; 12 due to tumor recurrence, 2 due to secondary arthritis.

Recurrent GCTB can be treated by further curettage with additional burring and cementing with an acceptable re-recurrence rate of 21.7 %. The rate of patients finally needing an endoprosthesis is 20.9 %. Due to the high rate of pulmonary metastases recurrent GCTB may be considered as a severe disease.


G. Kuerzl W. Maurer-Ertl A. Leithner B. Liegl-Atzwanger H. Dobnig R. Windhager

Multifocal osteolytic lesions of the skeletal system are a challenge regarding diagnosis especially when multi-nucleated giant cells which are not specific for a tumour entity are found in the histological specimen. Therefore multiple differential diagnosis have to be considered such as metastases, primary malignant bone tumours, multicentric giant cell tumour of bone and brown tumours of primary hyperparathyroidism.

A 49 year old woman underwent medical investigation in an external surgical department due to right hip pain after a fall. The radiologic skeletal status surprised with multiple osteolytic pelvic lesions and one tumour in the left scapula and first histological diagnosis described a giant cell tumour of bone with malignant aspects. After confirmation of this diagnosis by a second histopathological inquiry accomplished by a bone tumor specialist the patient was transferred to our tumour centre. To exclude the differential diagnosis of brown tumours a close look on the parathormon level was done which revealed an exorbitantly high serum amount of 922.7 pg/ml (normal 15–65 pg/ml). Further examination confirmed a parathyroid adenoma. After its extirpation serum levels of parathormon decreased and two months after therapy with high dose calcium substitution radiologic controls show a decline of osteolysis with bone consolidation.

Brown tumours of hyperparathyroidism have always to be considered as a rare differential diagnosis of multiple giant cell containing tumours. The disease cannot be distinguished by the histological pattern but can very easily be excluded by normal parathormon levels. First step of therapy in brown tumours should be surgical extirpation of parathyroid adenomas or carcinomas followed by an endocrinological regime. Only failure of this treatment requires further surgical stabilisation of the bone lesions.


T. Lovse W. Maurer-Ertl M. Pechmann M. Glehr A. Leithner R. Windhager

Giant cell tumor of the distal radius is associated with a high local recurrence rate. En bloc resection of the distal radius and reconstruction using osteoarticular allograft, curettage with PMMA blomb, and allograft arthrodesis are established methods. The aim of the study was to evaluate the functional outcome of our patients with the DASH-Score and the Mayo Wrist score.

In the last 7 years six patients were treated at our department due to a giant cell tumor of the distal radius. Two patients were primary treated with an en bloc resection. The other four were primary treated with curettage packing of the defect with polymethylmethacrylate. In two of these cases a secondary en bloc resection was performed for local recurrence. For evaluation of function in daily live we used the DASH score and the MAYO wrist score.

The mean bone resection length was 5,25cm (5–6 cm).All four patients treated with en bloc resection (primary or secondary) had no recurrence but in two out of that cases a re-operation was necessary because of non union.

At a mean follow up from 27 months (4–95) there were no recurrences or metastases at all.

The flexion/extension of the wrist in currettaged radius was 60°/80° compared with 38°/68° in reconstructed radius. The pronation/suppination was 90°/90° in the currettaged ones versus 77°/77° in the allograft replaced ones.

The functional outcome evaluated with Mayo Wrist Score and DASH score showed an excellent outcome for both groups (84/7,7 Allograft < -> 85/10 Currettage)

Functional outcome of distal radius resection reconstruction using an allograft is highly satisfactory compared with the literature, however we experienced a high risk for pseudoarthrosis. For prevention of non union simultaneous bone grafting at the index operation could be advisable.

Thus allograft reconstruction of the distal radius represents a valuable alternative to arthrodesis.


B. Lehner A. Dimitrakopoulou-Strauß S. Weiss D. Witte

Following intralesional resection of giant cell tumour local recurrence happens in up to 40% depending on type of treatment. Common plain radiography or Magnetic resonance tomography (MRI) often has the problem not to discriminate between scar and recurrent tumour tissue in the cement-tissue border of lesions treated with cement packing. The value of Positron emission tomography (PET) for diagnosis of tumour and recurrence was investigated in these patients.

In 19 patients with giant cell tumour dynamic PET using F18-Fluordeoxyglucose for estimation of FDG turnover was carried out. PET was performed before surgery and as follow up. In all patients giant cell tumour was treated by curettage followed by burring and cement packing. Giant cell tumour was shown by histology in all patients.

All giant cell tumours showed a specific PET pattern with a very high standard uptake value (SUV) of 4.8 in median. In follow up after surgery this value dropped to 0.3. In one case also pulmonary metastasis could be demonstrated. Recurrence was suspected in the follow up in 5 patients by MRI or plain radiography. In all these patients PET could show an elevated SUV above 4.0. In these 5 patients surgery was performed and recurrence could be proven by histology. In one patient MRI showed signs of recurrence but PET showed a SUV of 1.3. In the revision surgery no tumour could be found. In one patient MRI was negative but PET showed a SUV of 5.2 indicating re-recurrent tumour which could be demonstrated by histology.

We conclude that PET is a very helpful tool not only in the first line diagnosis of giant cell tumour but also in diagnosis of metastatic disease and especially for detection of recurrent tumour.


AP v Noort-Suijdendorp JR Kroep H Gelderblom PCW Hogendoorn AHM Taminiau PDS Dijkstra

Giant cell tumour of bone (GCT) is a primary osteolytic neoplasm, histopathologically characterized by osteoclast-like giant cells and clinically characterized by local bone destruction and high recurrence rates. There is a need to identify risk factors for recurrence. In order to reduce the recurrence rate we initiated an international, multicenter, randomised phase II trial with adjuvantzoledronic acid as compared to standard care for high risk GCT patients.

One hundred and sixteen GCT patients, treated at the LUMC from 1971 to 2006, with a minimal follow-up of a year, were retrospectively analysed for the following risk factors for local recurrence: GCT grade III and tumour involvement into soft tissue caused by ingrowth or fracture. Resection was used as treatment in 21 patients (group A), intralesional surgery with cement or adjuvant in 24 (group B) and intralesional surgery with cementation and adjuvant in 71 patients (group C).

GCT recurred in 5% (1/21) in group A. Risk factors were found in 90% of patients without recurrence (18/20). Group B shows a recurrence of 25% (6/24). Risk factors were found in 83% (5/6) of recurring GCTs, compared with 28% in patients without recurrence. In group C, a recurrence rate of 23% (16/71) was found. Risk factors were present in 94% (15/16) of recurrences, compared to 36% (20/55) in patients without recurrence.

Soft tissue involvement and GCT grade 3 and up are risk factors for recurrence in GCT. Recurrence rates are lowest when resection is used. Risk factors may influence the choice of treatment. High risk patients may benefit from resection or systemic treatment with adjuvant therapy.


A.P. v. Noort-Suijdendorp P.D.S. Dijkstra A.H.M. Taminiau

Giant cell tumors (GCT) of the sacrum have a high recurrence rate, up to 33%. Treatment of Giant Cell Tumors (GCT) of the sacrum has many options. Although curettage is more often performed than partial sacral resection the indications are not well described. Large resection in the sacral area is limited, and adequate local adjuvant therapy potentially damages the nervous system. Therefore the type of surgical treatment of sacral GCT is still under debate.

The purpose of this study was to compare clinical outcome after surgical treatment in GCT of the sacrum using two different surgical techniques: curettage and Extended Cortical Excision (ECE).

Pre-operative embolisation was routinely performed, followed by curettage or PSR followed by reconstruction if indicated. Between 1994–2005 11 patients were treated for GCT of the sacrum. Eight were female, 3 men. The median age was 43.5 (14–66) years. The median follow-up period was 60 (6–156) months. Five patients were eventually treated by ECE. The other patients were operated on using different techniques, mainly curettage and/or adjuvant therapy.

Two patients died disease-related 42 and 6 months after primary treatment, both metastasized. All other patients are alive and currently disease-free. Six patients had a recurrence, after 33 (4–140) months. Three patients had a recurrence twice. Three patients received radiotherapy, 1 as palliative treatment and 2 as (adjuvant) therapy for recurrence. No recurrences were seen after ECE compared to 86% (6/7) after curettage only, and 50% (2/4) after curettage with adjuvant therapy.

Extended cortical excision may improve the recurrence rate in sacral GCT.


C. Menna R.J. Grimer S.R. Carter R.M. Tillman A. Abudu L. Jeys

Low grade central osteosarcoma is a rare intramedullary bone producing tumour. It accounts for only 1–2% of all osteosarcomas. Due to the indolent nature of low grade central osteosarcoma, achieving a correct and prompt diagnosis is the real challenge both from imaging and histology, particularly as it may resemble a benign condition, i.e. Fibrous Dysplasia.

We have reviewed 15 cases of low grade central osteosarcoma with long term follow-up (2 to 22 years) to identify problems in diagnosis and treatment and to assess outcome.

There were 7 females and 8 males with a mean age of 37 yrs (range 11 to 72 years); 13 cases arose in the lower limb (8 femur, 4 tibia, 1 os calcis), 1 in the pelvis and 1 in the upper limb. The average duration of symptoms prior to presentation was over 2yrs. A primary diagnosis of low grade central osteosarcoma was achieved for only 6 cases (4 open and 2 needle biopsies), in the other 9 the primary diagnoses were GCT, cystic lesion or fibrous lesion (both benign and malignant) and all of them had undergone treatment (usually curettage with or without bone grafting for this). Definitive treatment was with surgery attempting to obtain wide margins. Marginal excision was associated with local recurrence in three cases but there were no local recurrences in patients who had a wide excision, even in those with prior treatment. Only one patient has died following the development of multiple metastases after 9 years. The survival rate is 90% at 15 years.

We present this study to show the difficulties in diagnosing this rare type of osteosarcoma and to highlight the importance of wide surgical margins to obtain local control.


L. Coll Mesa M. González Gaitano N. Hernández de Leòn P. Sánchez Hernández M. A. Ayala Rodrigo J. Vega Sanginés M. Porras Sánchez

Osteosarcoma arising on the periosteal aspect of bone comprises a biologically heterogeneous group of neoplasm. Parosteal osteosarcoma is a low-grade malignant tumour originates at the surface of bone comprising 3–6% of all osteosarcomas and 2% of primary osseous neoplasms. It is most common in young and middle-aged adults and occurs most frequently on the posterior aspect of the distal femur or tibia. The radiologic appearance is often characterized by a large, lobulated, ossific mass in a juxtacortical position. Cortical thickening without aggressive periosteal reaction can be present. Typically the medullary canal is uninvolved. Wide surgical resection and reconstruction is the treatment of choice. The overall prognosis for patients with this lesion depends on the stage of the tumor at presentation. The prognosis for a Parosteal osteosarcoma is generally excellent.

We present an uncommon case of elderly women 70 year-old with a surface osteosarcoma in right femur concomitant with disseminated Breast Carcinoma. The radiological findings showed a juxtacortical mass on the anteromedial aspect of the junction between the mid-third and the distal third of the right femur with areas of new bone formation mimicking Periostal osteosarcoma. We observed a typical Parosteal osteosarcoma when the biopsy was performed. The elected treatment was a wide resection with PTR MUTARS and adjuvant chemotherapy controlling local and systemic diseases.

In conclusion, due to the treatment for the juxtacortical osteosarcomas varies with the diagnosis, an accurate evaluation and appropriate management must be executed to have the best outcomes.


A. Kumar R. Kinkar Jha S. Alam Khan C. Shekhar Yadav S. Rastogi S. Bakshi

Clear-cell sarcoma is a very rare tumor, and is almost always associated with tendons or aponeuroses or is metastatic from other organs. Sporadic cases only have been reported involving primarily the bone or extending from soft tissues to surrounding bones. To our knowledge, the ilium has not been previously reported as the primary site for clear cell sarcoma.

We report a rare case of Primary clear cell sarcoma involving right ilium region in a 18-year-old boy presented with a painful swelling over right ilium and limp on right lower limb of ten month duration. He was initially suspected having tuberculosis based on clinicoradiological evaluation and diagnosis of primry clear cell sarcoma could be established on histopathology. Patient was treated with partial excision of the ilium, the remaining ilium was fused with sacrum. Stabilization was achieved with a cortical autograft harvested from the right fibula and fixation with a titanium plate.

The patient had no local recurrences but the plate holding ilium to sacrum broke and was removed in the subsequent surgery after which he developed Trendelenberg’s gait.


Y. Yurttaş M. Başbozkurt M. Kürklü B. Demiralp H. Özkan S. Bilgiç

Giant cell tumor of the tendon sheath (nodular synovitis) is a benign soft tissue tumor, usually affecting older women, that most often occurs in the interphalangeal joints of the fingers, wrist or knee. Malign giant cell tumor of the tendon sheath is rare.

We present a case of a 56-year-old woman presented with a slow-growing, painless mass on the anteromedial aspect of the ankle 5 year duration. Apparent rapid enlargement of the mass was observed and went under surgery. The resected tumor, measuring 50x21x28 mm.cm, was encapsulated and located on the tibialis anterior tendon sheath of the ankle.

The tumor was intracapsular and its margins was clear. We performed radioterapy. The patient was quite well at the last follow-up 12 months after wide excision. It seems likely that may expect the good outcome, superficial location and the minority of the tumor composed of malignant component. However, long-term follow-up is mandatory, due to the poor prognosis.


H. Nouri L. Abid M.H. Meherzi M. Ouertatani K. Zehi M. Mestiri H. Jaafoura

Adamantinoma is a primary low-grade, malignant bone tumor that is predominantly located in the mid-portion of the tibia. The aetiology of the tumor is still a matter of debate. Histologically, classic adamantinoma is a biphasic tumor characterized by epithelial and osteofibrous components that may be intermingled with each other in various proportions and differentiating patterns.

We report here a particular morphologic variant of adamantinoma characterised by the loss of classic epithelial differentiation. A 17 year-old teenager presented with a long history of a tumor in the left leg. Explorations revealed an osteolytic lesion of the middle shaft of the left tibia with a huge mass invading soft tissues. An intra medullar bone lesion with benign appearance was observed in the right tibia. CT of the chest revealed lung metastases. Histologically, we observed in the left side a pattern of spinde-celled high grade sarcoma without any evident differentiation. Spindle-shaped tumor cells express cytokeratins and vimentin. Ultrasturctural study showed tonofibrils and desmosomes and was helpful to recognize the epithelial nature of the tumour. The diagnosis of dedifferentiated adamantinoma was retained. In the right tibia biopsy revealed fibrous dysplasia. Amputation above the knee was performed followed by chemotherapy. One year later, the patient is still alive with multiple lung metastases.

In our study, we discussed the clinico-pathologic features of this particular pattern of adamantinoma as well as its association with fiobrous dysplasia in this case. A review of literature was done.


H. Nouri L. Abid M.H. Meherzi M. Ouertatani K. Zehi M. Mestiri

Clear cell meningioma is a rare subtype of meningiomas graded II according to the World Health Organisation classification. In spite of its benign appearance, clear cell meningioma has an aggressive behaviour and it is characterized by its inordinately tendency to metastasize.

The purpose of this study is to discuss the clinico-pathological features of this subtype of meningiomas as well as the metastatic pathways.

We wish to report a rare case of a clear cell meningioma metastasizing to the sacrum 17 years after the removal of the primary tumour. A 26 year-old man was referred to our centre for low back pain related to a lytic lesion of the sacrum. He had a history of a tumour of the forth cervical vertebra that was removed when he was 9 year-old. CT scan revealed an osteolysis of the entire sacrum invading the intrapelvic organs and the sacro-iliac joints. Open biopsy revealed a clear cell meningioma. That was the same pattern of the tumour removed 17 years earlier. Chest CT showed lung metastases. The patient was managed conservatively by palliative radiation therapy. One year later, he experienced improvement of pain and walk. The mass was stable.

Clear ell meningioma is an aggressive tumour with a potential to spread via cerebro-spinal fluid and haematologically. Patients with such a tumour should be closely followed for a long time.


M.T.R. Parratt D. Delaney K. Gokaraju B.G.I. Spiegelberg A.M. Flanagan S.R. Cannon T.W.R. Briggs

Primary solitary fibrous tumour (SFT) of bone is extremely rare with few cases reported in the literature. The incidence of the lesion is 0.08% of all primary bone tumours (0.1% of primary malignant bone neoplasms). Previously, such lesions may have been reported as haemangiopericytoma (HP).

Despite being previously considered as separate entities, the two types of tumour (SFT and HP) are now generally accepted as related, sharing similar morphological and immunohistochemical features. Cytogenetic and molecular analysis has, so far, been unable to unite or divide the two. Although frequently having a histologically benign appearance or being labelled as intermediate grade, these tumours may exhibit an unpredictable clinical course and behave in an aggressive manner. We present two cases of osseous solitary fibrous tumour (cellular haemangiopericytoma).

Using the histopathology and bone tumour databases at our institution, we identified two patients (one female aged 21 and one male aged 40) with a histopathological diagnosis of osseous SFT. The site of primary tumour in both patients was the sacrum. In the female patient, the lesion was confined to the sacrum and she underwent curettage. In the male patient, the tumour extended beyond the sacrum to the sacro-iliac joint, ilium and gluteal mass, therefore, total sacrectomy was performed. At presentation neither patient had evidence of metastatic spread.

The female patient was disease free at four years with no evidence of recurrence of metastases. The male patient developed metastases in both lung fields and bone (ribs, vertebrae) three years post-operatively and died four years post-operatively.

Orthopaedic surgeons and histopathologists should remain aware of SFT due to its erratic behaviour and the recent move towards unifying it with HP in a continuous spectrum. We recommend early staging and treatment of these tumours, even for histologically benign/low grade lesions, due to their potentially aggressive behaviour.


F. Ott A. Leithner M. Pechmann B. Liegl-Atzwanger R. Windhager

Periprosthetic osteolysis after total joint replacement is a well described complication. This normal slowly increasing process is caused by infection, implant loosening or more special, debris induced. However malignant processes may rarely occur at exact this location too. Based on clinical presentation and imaging it is sometimes difficult to exclude a local malignant process. We report two cases of extensive osteolysis after total hip replacement, including their follow up and a review of the relevant literature.

Two female patients developed massive osteolysis in periprosthetic areas (pelvic area and proximal femur as well as distal femur) after being treated by total hip arthroplasty 14 and 18 years ago. In both cases a tumorous process was suspected after imaging and they were therefore referred to our clinic. In one case a rapidly progressing soft tissue swelling with extensive peri-articular osteolysis was considered to be a malignant tumour. After an incisional biopsy, an embolisation had to be performed due to continuous massive bleeding. Histology revealed a superinfected polyethylene disease, treated with a two stage revision surgery. The second patient presented with an impending fracture due an unusual osteolysis at the tip of the stem. Here again polyethylene debris was found at biopsy.

Extensive osteolysis and/or soft tissue swelling caused by polyethylene debris may sometimes be difficult to differ from a tumorous process. As a guideline presented by Min WK. et al in 2008 a reactive bone-destroying process normally proceeds slowly in contrast to a more rapid progression in malignant disease. However, as presented in the first of our cases, exemptions may occur. In these cases a biopsy or at least a frozen section at operation should be obtained in order to exclude a real neoplasm.


B. Rose G. Tamvakopoulos E. Yeung R. Pollock J.A. Skinner T.W.R. Briggs S. Cannon

Granular Cell Tumours are rare mesenchymal soft tissue tumours that arise throughout the body and are believed to be of neural origin. They often present as an asymptomatic slow-growing benign solitary lesion but may be multifocal. One to two percent of cases are malignant and can metastasise.

Described series in the literature are sparse. We examined our database and identified eleven cases in ten patients treated surgically and followed-up for a period of over six years (May 2002 to January 2009) in our regional bone and soft tissue tumour centre.

Five tumours were located in the lower limb, four in the upper limb and two in the axial skeleton. Mean patient age was 31.2 years (range 8 to 55 years). Excision was complete in one case, marginal in five cases and intra-lesional in five cases. No specimens showed evidence of malignancy. No patients required postoperative adjuvant treatment. Mean follow-up was 19.3 months (range 1 to 37 months), with no cases of local recurrence. One case was multi-focal.

Histopathological examination revealed the classical features of granular cell tumour in all cases. Typically, tumour cells were diffusely and strongly positive for S100 protein by immunohistochemistry, whereas the other markers tested were negative.

We believe this case series to be the largest of its type in patients presenting to an orthopaedic soft tissue tumour unit. We present our findings and correlate it with findings of other series in the literature.


S. Tauber S. Scheipl G. Ranner A. Leithner M. Sperl R. Windhager

Epimetaphyseal lesions may occur within congenital dysplasia or can be linked to metabolic, inflammatory and systemic diseases. They can also be caused by trauma or be due to malign or benign neoplasms.

Our case-report concerns a 4-year old boy who was x-rayed the day after falling from a chair and twisting his right ankle. X-ray showed an epimetaphyseal lesion of about 2 cm in diameter, located eccentrically in the lateral site of the distal tibia. A unilamellar periostal reaction could be detected in the lateral slices. On MRI, the lesion seemed to be of chondromatous origin and showed smooth borders with no evidence of surrounding oedema. The adjacent epiphyseal plate appeared as untypically fragmented. In CT-scans, the ventrolateral cortical bone was partially perforated and the lesion showed a tender sclerotic border. Due to the benign aspect, we agreed upon radiologic controls in order not to harm the epiphyseal plate by biopsy. MRI follow-ups revealed a slight but continuous growth. The lesion assumed an increasingly eccentric, tongue-shaped configuration with simultaneously increasing calcifications and mineralisations. After 5 years of radiological surveillance, the patient showed no evidence of growth-disturbance and did not report pain, but an increasing feeling of pressure when wearing boots.

Traumatic causes as well as metabolic, inflammatory and systemic diseases can, considering the patient’s history and clinical status, be put aside. The benign aspect combined with the long-term follow-up rules out malignancies. A chondroid matrix with increasing areas of mineralisation imply the diagnosis of a chondromatous tumour, although radiomorphology does not support this assumption; especially not, if age, clinical presentation, eccentric epimetaphyseal location and the involvement of the epiphyseal plate are taken into account. Among the entities left for differential-diagnosis, a dysplastic process e.g. Dysplasia hemimelica, must be considered, although doubts remain. For confirmation of diagnosis, further radiological and clinical surveillance will be conducted.


B.G.I. Spiegelberg M.D. Sewell M.T. Parratt K. Gokaraju G.W. Blunn S.R. Cannon T.W.R. Briggs

This case highlights the close association between osteo-fibrous dysplasia (OFD) and adamantinoma, drawing attention to the role for more radical treatment options when treating OFD. We discuss the advancements in joint-sparing endoprostheses using bicortical fixation. Finally we describe a unique biomedical design allowing for manufacture of an end cap to allow amputation through a custom made joint-sparing proximal tibial replacement as opposed to an above knee amputation.

A 37 year old presented 7 years ago having sustained a pathological fracture of her tibia. Subsequent biopsy revealed OFD, curettage with bone graft was performed. She later developed recurrence, two percutaneous biopsies confirmed OFD. 6 years following her initial diagnosis she was referred to RNOH with further recurrence, a biopsy at this stage revealed a de-differentiated adamantinoma. A joint-sparing proximal tibial replacement was performed and adjuvant chemotherapy administered, she remained well for one year. Recurrence was noted at the distal bone-prosthesis interface, histology revealed a high grade dedifferentiated osteosarcoma, limb preservation was not deemed possible and an amputation was performed through the prosthesis. The proximal tibial device was uncoupled leaving a residual 7 cms insitu, a small custom made end cap was attached to the remaining prosthesis and a myocutaneous flap fashioned over it, this ultimately enabled the patient to mobilise well with a below–knee orthotic device.

This case highlights the need for more radical surgery when treating cases of OFD and the relationship between OFD and adamantinoma. It also introduces a joint-sparing proximal tibial device for use in proximal tibial tumours that do not invade the proximal tibial metaphysis. The biomechanical design solution has given us the unique option of preserving the knee joint allowing the patient a below knee amputation whereas previously an above knee amputation would have been performed thereby significantly reducing her functional outcome.


Y. Yurttaş M. Başbozkurt M. Kürklü B. Demiralp H. Özkan S. Bilgiç

Although soliter lipomas are very common soft tissue tumors, osteolipomas are rare.

We present a case of a solitary osteolipoma of the inguinal region in a 37 year-old male who was referred for a inguinal mass causing pain and compression of the neurovasculer structures of the inguinal region. The computed tomography scan helped to clinch the diagnosis and histpathology confirmed it. The well- demarcated, firm tumor was excised arising adjacent to the neurovasculer structures of the inguinal region.

Osteolipomas should be kept in mind in the different diagnosis of soft tissue masses as an extremely rare benign lesion.


Full Access
L. Coll Mesa M. González Gaitano N. Hernández de Leòn R. Ucelay Gòmez P. Sánchez Hernández M. A. Ayala Rodrigo J. Vega Sanginés M. Porras Sánchez

Primary vascular leiomyosarcoma is a rare, aggressively malignant connective tissue tumour, which arises from smooth muscle cells of the vessel walls. This neoplasm involves the extremities in about of 30% reported cases. Preoperative angiograms with CT scans and MRI in conjunction with the clinical signs of vascular and biopsy and immunohistochemical studies are useful tools in the diagnostic and operative planning of intra-vascular leiomyosarcoma.

We report the case of a 34 year-old woman who was referred to us presenting pain, palpable mass in the right inguinal area and tenderness, deep venous thrombosis symptoms and motor dysfunction of her right leg. Biopsy was performed with the diagnosis of Leiomyosarcoma (IIB) of iliac and femoral right veins treated with wide resection and reconstruction of vessels with vascular prosthesis achieving excellent results.

In conclusion, complete surgical resection of the vessel segment is the therapy of choice. Adjuvant therapy, chemotherapy or radiation therapy combined with surgery, is often used for patients with poor prognosis.


V. Kumar K. Manish A. Javed S. Alam Khan C. Shekhar Yadav S. Rastogi

Ossyfying periarticular lipoma is a very rare entity. Lipomas undergo involutional changes like chondrification, calcification and very rarely ossification. These changes result in altered clinical, radiological and histopathological features leading to diagnostic challenge in differentiation from the soft tissue tumor like synovial sarcoma, liposarcoma and rhabdomyosarcoma.

We present a series of three cases of ossifying lipomas presenting as soft tissue tumor around the knee, shoulder and hip joints. All the tumors revealed calcification and ossification on plain X-rays and on MRI/CT Scans. Clinico-radiological evaluation lead to a similar diagnostic dilemma in our series and a confirmed diagnosis of ossifying lipoma became possible only after histopathology. All the three tumors were excised completely without any recurrence during last 3 1/2 years of follow-up.

We recommend the early imaging by MRI/CT scan with closed core biopsy to exclude the malignant pathology and complete excision of the tumor with early mobilization of the adjacent joint.


T.G.P. Grunewald I. von Luettichau G. Weirich U. Behrends R. Gradinger G. Jundt A. Wawer S.S. Bielack S. Burdach

Sclerosing epitheloid fibrosarcoma (SEF) is an extremely rare soft tissue sarcoma arising from connective tissue cells of mesenchymal origin. SEF mostly occurs in extraosseous sites in the soft tissue; however two cases of primary localization in the bone have been described. Despite benign cytological features the clinical course is complicated by a high local recurrence rate and late metastases. SEF represents a clinically challenging entity especially because no standardized treatment regimens are available.

We report a 16-year old female patient who showed persistent load-dependent pain focused on the right proximal tibia. Radiological evaluation revealed an osteolytic lesion and the diagnosis of a benign bone cyst was consented. The tumor was surgically removed. Only after recurrence of the tumor and repeated histopathological analysis diagnosis of SEF could be established.

Because of the bone localization of the tumor the patient underwent standardized neoadjuvant chemotherapy analogous to the European-American EURAMOS-1 protocol for the treatment of osteosarcoma followed by tumor resection and endoprothesis. Histopathological analysis of the resected tumor showed > 90% vital tumor cells suggesting no response to the neoadjuvant chemotherapy. Therefore, therapy was reassigned to the CWS protocol of the German Society for Pediatric Oncology and Hematology (GPOH) for treatment of soft tissue sarcoma. To date, the patient is alive and no metastases of the primary tumor can be detected.

SEF represents a taunting clinical entity due to deceptive histopathological features and rare occurrence. Localization in the bone represents an additional challenge with regards to the therapeutical approach. Standardized treatment regimens are currently not available for SEF. This case report, to our knowledge, is the first outlining a therapeutic approach in detail. Our data suggest that SEF may be resistant to a chemotherapy regimen containing Cisplatin, Doxorubicin and Metho-trexate despite close association to the bone, possibly indicative of the soft tissue histogenesis of this tumor. The response to the soft tissue sarcoma targeting CWS chemotherapy remains to be determined.


M. Jagodic

A case of advanced retroperitoneal leiomyosarcoma is reported in a patient, who experienced a complete regression of her fatal illness.

A 66-year old woman presented with a 1-year history of intermittent lower abdominal pain. An ultrasonogram (USG) and computed tomography (CT-scan) revealedmultiple soft tissue masses particularly in the lower retroperitoneal space and also 3 liver nodules. USG-guided biopsy was done and histologically confirmed poorly differentiated leiomyosarcoma. The patient underwent successful macroscopically complete en bloc resection of all tumor masses with the exception of 12 liver metastases which had been resected 6 weeks after the initial surgery. 11 months later USG showed disease progression with diffuse inoperable liver metastases, intraperitoneal and retroperitoneal tumor nodules. We introduced salvage chemotherapy (ChT), using intravenous infusion of ifosfamide 1.8 g/m2 on days 1–3 with mesna, and intravenous bolus injection of doxorubicin 60 mg/m2 on day 1. After 4 courses of treatment USG showed partial regression of metastatic disease. When the patient received the 8th, i.e. the last cycle of ChT, USG confirmed further disease regression with only 2 residual metastases in liver. 6 months later USG showed further regression of liver metastases. Another follow-up USG at 9 months and 12 months did not reveal evidence of residual metastases. Almost 2 years after the end of ChT the patient is asymptomatic, well and has no evidence of disease at 41 months after the diagnosis.

The “spontaneous” further regression of metastatic leiomyosarcoma after the end of salvage ChT in our patient would be exceptional phenomena. Although we cannot exclude the remote possibility of “delayed” further response to ChT, generally poor response rate to ChT in leiomyosarcoma would make it very unlikely.


Y. Yurttaş M. Başbozkurt M. Kürklü C. Yıldız H. Özkan S. Bilgiç

Echinococcal cysts are mostly found in the liver followed by the lungs, spleen, ovaries, kidneys, brain, bones and heart, but rarely elsewhere in the body. Disease can take place either directly from contact with infected dogs or indirectly from the ingestion of contaminated water or food. Skeletal disease is rare and is usually due to secondary extension after haematogenous spread of the infection.

We present a case of hydatid cyst involving superior and inferior pubic ramus and retrorectal space in a 22 years old male patient, which is not a common site for the occurrence of this disease. Total cystectomy was performed for retrorectal cyst, curettage and bone cementing was done for the bony involvement.

He was well after 1 year follow up. Diagnosis is usually difficult and MRI is a good tool for reaching diagnoses. Curettage and bone cementing can be a treatment option for decreasing bony recurrences.


J. Melo Sousa A. Pereira P. Costa J. Seabra Lopes P. Cardoso

Condromixoid sarcoma is a rare tumor (about 2,3% of soft tissue sarcomas in one of the series published) occurring mainly in muscular part of extremities. The reconstruction after block resection of tumor lesions of dorsal column invading the thorax almost always represents a great challenge to the surgical team. The case presented reports an infrequent location of this rare tumor what highlights it in an oncologic point of view. From the surgical point of view the surgical steps of wide tumor resection are described and of the reconstruction of the dorsal column and the involved thoracicregion (adjacent to vital structures) what resulted in an asymptomatic correction.

The authors present a case of a 47 years old patient operated to a volumous dorsal condromixoid sarcoma, practically asymptomatic, with invasion and compression of the neurological space and thoracic cavity. After biopsy, a wide resection of the tumor was made, using a double surgical approach (anterior and posterior), with resection of posterior part of vertebras D6–D9 and part of the 7th, 8th and 9th costal arches. The reconstruction consisted in correction of thoracic wall with prosthesis and stabilization of column with pedicular instrumentation from D5 to D11. The post-operatory recover had no complications and in clinically the patient is asymptomatic.

Only the elevated level of suspicion conducted the realization of biopsy in an apparent innocent lesion. The Condromixoid sarcoma occurs rarely in the nervous axis, what created some difficulties in the histological diagnosis. The dimensions of the tumor mass and its localization were object of great discussion and of detailed surgical planning. After a massive surgical resection, the clinical result after 2 years of follow-up is excellent (patient asymptomatic). The almost inevitable oncological decision of surgery in a malignant tumor with medullar cord compression was the only effective way of treatment.


B. Rose G. Tamvakopoulos K. Dulay R. Pollock A. Flanagan J.A. Skinner T.W.R. Briggs S. Cannon

Low-grade fibromyxoid sarcoma (LGFMS) is a rare soft tissue neoplasm most commonly presenting in young to middle-aged adults. LGFMS is an indolent tumour with a deceptively benign histological appearance. Local recurrences are not uncommon and the tumours can metastasise. A particular gene translocation, FUS-CREB3L2, has been shown to occur commonly in cases of LGFMS. The literature suggests that the FUS-CREB3L2 fusion-gene is a specific marker for LGFMS.

We report the cytogenetic analysis of 29 cases of LGFMS, and clinical outcomes of 21 patients treated surgically between 1998 and 2008 at our regional bone and soft-tissue tumour centre. The mean age was 45.4 years. The most common location of tumours in our series was the lower limb. The mean follow-up was 30.1 months (range 0 to 125 months). To date, there have been no cases of local recurrence or metastasis.

Fifteen of our patients (52.2%) were FUS-CREB3L2 translocation-positive. This suggests either that the translocation incidence in our LGFMS series is lower than other studies, or that reverse-transcriptase polymerase chain reaction (PCR) is substantially less sensitive than the literature suggests. The patients in this series testing positive presented at a younger age (38.2 years, compared to 45.6 years), and had larger tumours than their negative counterparts (mean diameter 97.6mm, compared to 65.2mm), although there was no difference in clinical outcome.

We conclude that PCR testing for the FUS-CREB3L2 translocation is a useful tool for confirming the diagnosis of LGFMS, but has no role in predicting short-term clinical outcome. In our experience it is not necessary to perform wide excision, and marginal margins are adequate. Longer-term follow-up is required to elucidate whether the previously reported recurrence and metastasis rates are a true reflection of the nature of this tumour, and may identify differences in the long-term clinical outcome between translocation-positive and negative patients.


T.C. Pansuriya J. Oosting K. Szuhai A.H.M. Taminiau S.H.M. Verdegaal L. Sangiorgi R. Sciot P.C.W. Hogendoorn J.V.M.G. Bovee

Ollier disease is a rare skeletal disorder. It is characterized by the occurrence of multiple enchondromas with a marked unilateral predominance mainly affecting medulla of the metaphyses and diaphyses of the short and long tubular bones of the limbs, especially the hands and feet. The risk of malignant transformation is suggested to be up to 35%. We hypothesise that Ollier disease is a mosaic condition as it is polyostotic and because of its unilateral predominance. Here we aimed to identify molecular defects in Ollier disease related enchondromas and chondrosarcomas using high resolution single nucleotide polymorphism (SNP) array approach. Affymetrix SNP 6.0 was performed on 67 samples which include 10 blood samples and 3 matched blood-saliva samples as a control; 13 enchondromas and 26 chondrosarcomas of different grades from 30 Ollier patients and normal DNA from 12 Ollier patients for paired comparison.

All samples were divided into three groups: normals, enchondromas and chondrosarcomas. The number of numerical genomic changes in the chromosomes were not different for the enchondromas (p=0.36) while large genomic aberrations were seen in chondrosarcomas as compared to normals (p=0.01). Copy number variation (CNV) analysis showed 95K amplification at 4q13 in 5 out of 13 enchondromas and a 2K deletion at 14q11 in 6 out of 13 enchondromas. Paired loss of heterozygosity (LOH) analysis failed to show LOH in 5 enchondromas at higher resolution. Paired LOH was observed at 3q, 5p, 6p, 6q, 7q, 9p, 12p, 13p and 13q in 7 high grade chondrosarcomas associated with loss of chromosomes.

The results of this study indicate involvement of chromosomes 4 and 14 for the development of enchondromas. We were unable to detect LOH in enchondromas at 1Mb resolution containing approximately 500 SNP probes. High grade chondrosarcomas showed LOH at different chromosomes. In future, we will study LOH and CNV changes at gene level and select candidate genes.


Full Access
M.T.R. Parratt J. Donaldson B.G.I. Spiegelberg K. Gokaraju R. Pollock J.A.M. Skinner S.R. Cannon T.W.R. Briggs

Elastofibroma dorsi is a rare, benign, slow-growing ‘pseudotumour’ classically presenting as an ill defined mass at the inferior pole of the scapula. Typical symptoms include mass, pain, scapular snapping and impingement like features. There is a predilection for females after the fifth decade of life. The aetiology is unclear.

We identified 15 patients (21 tumours) with a diagnosis of elastofibroma. Seven lesions were found on the left side and fourteen on the right; bilateral lesions were found in six patients. The male:female ratio was eight:seven and mean age at presentation was 60.9 years (range 40 – 71). The mean duration of symptoms (most commonly pain, mass and scapular snapping) prior to presentation was 25.8 months. Eighteen tumours were excised with a mean follow-up of 4.2 years (0.25–16). Four lesions were diagnosed by combined MRI and CT guided biopsy, the remainder identified using MRI alone. All patients were asked specifically about symptoms, occupation, family history and employment history (including hobbies). Pain was assessed using the Visual Analogue Score (VAS) and functional outcome using the Stanmore Percentage of Normal Shoulder Assessment (SPONSA) Score. Range of forward flexion of the shoulder joint was also assessed.

In the operative group, the mean VAS score improved from 4.6 (0–10) pre-operatively to 2.5 (0–8) post-operatively. Mean SPONSA scores improved from 61.5% (20 – 100) to 81.8% (30 – 100). Mean pre-operative forward flexion was 135 degrees (70 – 180), this improved to 166 degrees (100 – 180) post-operatively. A high number of patients had been involved in occupations involving heavy lifting. MRI had a 100% sensitivity in identifying elastofibroma when correlated with histopathological evaluation.

This series demonstrates that elastofibroma may be reliably diagnosed using MRI alone and, in the symptomatic patient, pain and function may be improved through operative excision.


M. Massada A. Pereira R. Sousa P. Cardoso J. Lourenço

Primary synovial chondromatosis, defined by Jaffe (1951), is a rare, benign arthropathy, of unknown aetiology, distinguished by the chondroid metaplasia of the synovial membrane of the joint, bursa or tendon sheath, which leads to the formation of loose bodies, usually intra-articular. It is characteristically monoarticular and the knee, hip and elbow are the joints most commonly affected. The shoulder is a rare localisation and the extra-articular involvement even rarer, with only few cases presented in the literature.

The diagnosis is possibilited by the clinical examination and by the confirmation of the presence of multiple intra-articular loose bodies by roentgenographic studies and magnetic resonance (MR). The treatment is always surgical. Malignant degeneration of synovial chondromatosis into chondrosarcoma is described, although rare.

We report an exceptionally rare case of synovial osteochondromatosis of the shoulder with combined intra and extra-articular involvement in a 28 years old female patient, former athlete. She presented with a five-year history of shoulder pain and slight limitation of motion. Radiographic examination and magnetic resonance imaging led us to the diagnosis of synovial chondromatosis of the shoulder. The patient underwent arthroscopic removal of the intra-articular loose bodies and partial synovectomy. The subscapularis recess was then identified through an anterior deltopectoral incision and multiple loose bodies were removed from within.

Primary synovial chondromatosis of the shoulder is rare (5% of the cases) and the involvement of the extra-articular shoulder site is even rarer. Bloom and colleagues reported ten cases involving the shoulder in a meta-analysis of 191 synovial chondromatosis cases.

The arthroscopic removal of the loose bodies combined with the partial sinovectomy has demonstrated efficacy and low recurrence rates, allowing excellent visualization of the joint, decreased morbidity and early functional return. Nevertheless, we think that this approach may become insufficient when the extra-articular involvement is verified.


R. Rossi B. Rose N.D. Riley R. Jennings A. Saifuddin J.A. Skinner S.R. Cannon T.W.R. Briggs R. Pollock

Within a study group of 102 consecutive patients diagnosed at a supra-regional bone tumour unit with chondrosarcoma of the femur, tibia or humerus, an association with previously treated breast cancer was noted.

There were 58 female patients and 44 male patients. The study group contained six females (10%, mean age 53 years) who had previously been treated for breast cancer, a higher proportion than would be expected. They were referred following identification of a solitary area of increased activity on routine screening with isotope bone scan, presumed to be a solitary bony metastasis.

Most (86%) of this breast carcinoma sub-group had developed low-grade bone chondrosarcoma (Trojani grade 0.5-I) and only one case (14%) had developed high-grade chondrosarcoma (Trojani grade II-III).

A suspicious long bone lesion on bone scan in a patient with a past medical history of breast cancer must, therefore, not be assumed to be a metastasis without further investigation; the possibility of a chondral lesion should be considered. It is important that patients receive a full multidisciplinary team investigation prior to treatment in order to obtain the correct tissue diagnosis, as the management of these conditions is often different.

Our study suggests there may be a relationshipbetween patients previously treated for breast cancer and the development of subsequent chondrosarcoma.


A Schoenfeld J Kreshak N Kukkar P Nielsen A Rosenberg T Delaney W Kobayashi Z Duan K Raskin D Springfield H Mankin S Ferrone F Hornicek J Schwab

Chordoma is the second most common primary malignant tumor of the spine. These tumors rarely metastasize but are considered malignant and, when present in younger individuals, can be aggressive. In the setting of unresectable primary, recurrent, or metastatic tumors the current armamentarium of adjuvant therapy for this condition is very limited. Recent research, however, has identified potential targets for immunotherapy, including the tumor associate antigens High Molecular Weight Melanoma Associated Antigen (HMW-MAA) and B7H3.

The goal of this investigation was to correlate expression of B7H3 and HMW-MAA in chordoma tumors with disease severity and clinical outcome.

Tissue MicroArrays (TMA) were constructed using an automated arrayer to include 70 conventional chordoma tumors obtained from archives at our institution. Triplicate cores (0.6 mm in diameter) from each sample were created and two sets of cores were created for each chordoma specimen. One triplicate sample was incubated in a closed humid chamber with a pool of HMW-MAA-specific mAb, while the other was incubated with mAb specific for B7H3. Samples were washed in PBS and incubated with a secondary antibody for one hour. Staining was evaluated independently by two researchers and scored using validated systems. A retrospective chart review was performed for each chordoma specimen to determine demographic data, disease course, disease status at final follow-up and mortality. Clinical outcomes were then correlated to the expression of HMW-MAA and B7H3 within the chordoma lesions. Kaplan-Meier curves and Cox proportional hazard regression analysis were utilized to facilitate comparisons.

Chordoma tumors from 70 patients were included in this study. Average age at the time of presentation was 57.4 years (31–88 years). Average follow-up was 5.5 years (3.6 months-21 years). Forty-three patients developed recurrences and 10 had metastatic disease. Twenty-three patients (33%) had died of disease at the time of final follow-up. Ninety-seven percent of chordoma tumors stained positive for B7H3 while 44% stained positive for HMW-MAA. No correlation could be drawn between clinical course, recurrence rate, or mortality and tumor expression of B7H3 and HMW-MAA. Kaplan-Meier analysis did demonstrate a shorter survival time for patients whose tumors stained positive for HMW-MAA compared to those whose tumors were negative for the antigen.

The goal of this investigation was to correlate expression of B7H3 and HMW-MAA in chordoma tumorswith disease severity and clinical outcome. Results indicate that expression of HMW-MAA may be predictive of more aggressive disease and shorter survival. HMW-MAA and especially B7H3, in light of its near universal expression in the chordoma tumors studied here, may serve as potential targets for adjuvant immunotherapy.


A. Peyser D. Katz T. Berenstein Y. Applbaum

Percutaneos radiofrequency (RF) ablation of osteoid osteoma has been proved as an effective treatment. However, there is limited data regarding other tumors. It also has been described in the treatment of other benign and malignant tumors like chondroblastoma and metastasis. In fact, one of the reported cases of chondroblastoma that were treated with RF was radiological small lesion erroneously diagnosed prior to treatment as osteoid osteomas. It was diagnosed as chondroblastoma only retrospectively. The aim of this study is to describe the success of RF as a definitive treatment and as an alternative to traditional surgery for the treatment of large chondroblastoma and chondromyxoid-fibroma which were diagnosed as such prior to ablation.

From April 2006 to April 2007, 3 patients with chondroblastoma and 1 patient with chondromyxoid-fibroma were treated with RF ablation using cool-tip probe. Three procedures were done in the CT suit and one in the operating room. There were 3 girls and 1 boy. Mean age was 12 y 9 m (range 11 y 6 m – 14 y 6 m). Clinical and radiological follow-up was performed to assess outcome. The mean follow-up was 23.25 months (range 20–32 months).

Three patients healed after single treatment and one needed repeated treatment. No immediate or delayed complications were observed. Follow up MRI showed no enhancement in the lesion and an extra-lesional sclerotic ream signifying RF effect beyond the lesion area. All patients returned to complete normal painless function.

In spite of the small number of patients, percutaneous RF ablation was shown to be an effective and safe minimally invasive procedure for the treatment of chondroblastoma and chondromyxoid-fibroma, avoiding the morbidity of commonly used wide excision surgeries.


P.D.S. Dijkstra C.L.A. Vleggeert-Lankamp W.A. Moojen A.D.G. Krol A.H.M. Taminiau

Sacrococcygeal chordoma is a slow growing, malignant tumour with a clinical poor outcome due to a high local recurrence (LR) rate. Several studies emphasize that margin-free tumour resection is the most important predictor of survival and LR in patients with sacrococcygeal chordoma. However, a high recurrence rate still remains. The purpose of this report is to define the role of postoperative radiotherapy (RT).

15 patients (7 females and 8 males) underwent surgical treatment for sacrococcygeal chordoma between 1981 and 2003. The mean age at surgery was 54 (range 31–70) years. The mean follow up was 8.5 (range 4 – 20) years. Most patients suffered from local swelling and pain; only one patient had a mild urinary continence being the only pre- and postoperative neurological deficit. Mean time of preoperative complaints was 4.5 (range 0.8 – 8) years. In 9 patients an en bloc resection was performed, in 6 patients a subtotal resection was achieved. Most patients with a subtotal resection received RT (5/6 patients) following surgery, patients with en bloc resection only received RT (> 50Gray) after LR (6/9 patients).

After en bloc resection (no initial RT) all patients had local recurrence of the tumour with a mean time to recurrence of 3 (range 0.8 – 13) yrs. Only two patients in the group with subtotal resection had LR after 11 yrs. Six of 9 patients with LR after en bloc surgery received RT after recurrence and had a survival of at least 9 (range 5 – 20) years. There were no major complications. The time to recurrence was significantly longer in the group that received immediate RT after surgery, even after resection with irradical margins. There was no difference in survival between both surgical groups.

Our results suggest that postoperative RT is more important in the prevention of local recurrence than margin-free tumour resection. This supports the strategy to add radiotherapy as a standard adjuvant therapy to tumour resection in patients with sacrococcygeal chordoma.


E.V. Froehlich A. Leithner R. Radl A. Beham K. Bodo C. Schmid H. Stammberger A. Barth H. Schroettner K. Leithner F. Quehenberger B. Liegl R. Windhager

Chordomas are rare neoplasms originating from notochordal remnants. They usually affect the midline and the standard treatment consists of surgery and radiotherapy. The present study investigates the expression of survivin, DR4 and DR5 to evaluate potential molecular targets for future therapy-strategies.

The study-group included 33 chordomas obtained from 21 male and 9 female patients. At time of diagnosis the patients’ age ranged from 24 to 80 years (51.9 ys.). Tumours were located on the scull-base, in the sacral/coccygeal area and the column in 13, 10, and 7 cases, respectively. Tumour-volume, known in 16 cases, ranged from 3.6 to 668.2 cm3 (mean size 130.7cm3). Immunohistochemistry was performed with antibodies against survivin, DR4, DR5. The staining pattern (cytoplasmic and/or nuclear), percentage of positive tumour-cells and staining-intensity were evaluated.

Histologically the tumours were classified as classic, chondroid and dedifferentiated chordomas in 27, 2 and 1 case, respectively. Survivin expression was obtained in 87.5% of the cases. The staining pattern was cytoplasmic in all cases and an additional nuclear staining was detected in two. Staining-intensity was predominantly weak. In 87.9% of cases DR4 staining was investigated in more than 10% of the tumour-cells. The immunoreaction was cytoplasmic (87.9%) and a nuclear staining was additionally detected in two cases. The staining-intensity was predominantly weak. In 81.8% of the chordomas DR5 staining was obtained in more than 10% of the tumour-cells. The staining pattern was cytoplasmic (84.4%) and in one case cytoplasmic and nuclear. The staining-intensity was predominantly moderate.

We hypothesise, based on the availability of new chemo- or immunotherapeutic agents like Mapatumumab (agonistic human monoclonal antibody to DR4, tested in solid tumours) and YM155 (new small-molecular inhibitor of survivin, tested in solid tumours and lymphoma), that survivin, DR4 and DR5 may act as potential molecular targets in future therapy of chordomas.


N. Delepine S. Alkhallaf B Markowska H. Cornille G. Delepine

Desmoid tumour is an histological benign tumour. Nevertheless, peri-scapular relapses can decrease the function and intra thoracic progression threaten life. To prevent these complications, damaging treatment (radiotherapy, amputation) are sometimes proposed. To precise the optimal indications of treatment, we reviewed our cases.

Patients: from 1984 to 2008, we treated 11 patients with peri-scapula fibromatosis (mean age 42 (13–58)). Only 4 patients were seen at first hand, 7 for relapses (3 of them after radiotherapy).

Treatment was adapted to each patient, in function of age, history of illness, and risks of spontaneous evolution. En bloc extratumoral resection was performed each time, when it didn’t expose to heavy functional risk (8). The other patients were treated by contaminated resection, but never invaliding. 4 patients received pre or/and post-operative chemotherapy. 1 received Interferon alpha, and 7 tamoxifen.

Results: with a median follow-up 15 years 3 months, 7 patients suffered of recurrence. No patient died from disease (thoracic complications) or therapeutic complication9 patients are in complete remission and 2 in stable disease. Following radiotherapy, local relapses (7 cases) and repeated surgery, functional sequellaes are numerous: 2 circumflex nerve palsies, 3 articular stiffness. Major functional sequellaes came from radiotherapy (limb discrepancy, lung and thorax deformity, skin and muscle atrophy.

Conclusion: in this non predictable illness, therapeutic indications should individually balance risks of spontaneous evolution and of complications of treatment. Besides surgery, needed in fast all cases, but often insufficient, it must be considered the value of interferon, tamoxifen and/or chemotherapy. The most important concept is the necessity to treatment avoiding late sequellaes and particularly radiotherapy or mutilating surgery.


N. Delepine S. Alkhallaf B Markowska H. Cornille G. Delepine

The stiffness of the shoulder can result of many illness. Nevertheless, we observed a severe stiffness of the scapulo thoracic space only in fibromatosis. To precise the real diagnostic value of this symptom, we examined patients with different diseases of shoulder (tumoral and non tumoral).

The passive mobility of the shoulder of 11 patients with peri-scapular fibromatosis was compared to the mobility of those in 50 patients with non tumoral diseases of shoulder (arthritis and rotator cuff pathology), 50 peri-scapular soft tissues tumours, and 100 patients with primitive or secondary malignancies of humerus or scapula.

Results: in 10 of 11 patients with peri-scapular fibromatosis, the passive mobility of the scapulo thoracic spacewas severely impaired (less than 20°). In non tumoral pathology of shoulder, the passive mobility of the shoulder is frequently impaired but the stiffness hangs only on scapulo humeral articulation. In metastases, sarcoma and soft tissue tumour (except fibromatosis) the passive mobility of the scapulo-humeral joint is usually preserved and the mobility of the scapulothoracic space is always normal even in very huge tumours.

After treatment of fibromatosis, 9/11 patients are in complete remission and the mobility of their scapulo thoracic space restored. 2 patients are in stable disease and one suffers of a residual stiffness of the scapulothoracic space.

We conclude that the frozen scapulo thoracic is a specific symptom of peri scapulo thoracic fibromatosis. The restoration of the mobility of the scapulo thoracic after cure of the desmoid tumour confirms its specific role and represents a good marker of the tumoral evolution.


H.R. Dürr M. Niederhagen A. Baur-Melnyk V. Jansson C. Weiler M. Schlemmer M. Feist

Desmoid tumors are rare benign but aggressive lesions. They are characterized by bland-appearing fibroblasts, indistinct margins, and the ability of local invasion and recurrence. Though they are not cancer they may metastasize and can cause significant morbidity. Treatment is primarily surgical, although radiation or systemic therapy can be beneficial if surgery is not feasible. We retrospectively reviewed our patients since 1980 in respect to treatment modalities and outcome.

Between 1980 and 2008 26 patients (16 m, 10 f) with desmoid tumours had been surgically treated. The mean age with diagnosis was 37 years (7 – 69 years). The mean age at surgery was 46 years (10 – 81 years). 17 of the patients had only one resection. In 6 patients two resections, in 2 three resections and in one patient four resections had to be performed. Only 7 patients achieved a R0-situation. In 9 patients adjuvant radiotherapy was used. Two patients had several courses of Vinblastine or MTX based chemotherapy, three patients had Sulindac or Tamoxifen, several other patients combinations of different NSARs. All patients were still alive, one patient developed metastatic disease from the initial lesion in the groin to the foot. After an average of 17 months (7 – 42 months) 11 patients showed recurrent disease. 13 patients are without recurrence after an average of more than 9 years. In 4 patient stable disease is seen without progression in 42 to 156 months (Ø 95 months).

In conclusion desmoid tumours did show an inpredictable course of disease. Due to many alterations in treatment in the 28 years since the first patient of this study and the rareness of this disease no clear predicitve factor could be established. Remarkably no patient did need an amputation. A more detailed analysis regarding the dose effect of irradiated patients is intented.


W. Maurer-Ertl G. Kürzl E. Fröhlich A. Leithner N. Ghaffari-Tabrizi K. Bodo B. Liegl R. Windhager

Although fibrous dysplasia is a benign bone disease, in few cases patient are suffering from severe pain of the skeletal system. The aim of this study was to evaluate the current state regarding pain of patients with fibrous dysplasia treated at our hospital.

We searched our digital database since 1990 for patients with fibrous dysplasia. Subsequent we verified the histological diagnosis by reviewing the final pathologic report. Additional we called the identified patients by phone to make an enquiry about their pain course and associated treatment. For rating pain intensity we used a numeric rating scale with a range within zero to ten.

We identified 43 patients (21 male, 22 female) with an average age at initial diagnosis of 40 years (range 10 to 72years). The mean follow up was 6 years (range 1 to 23 years). Among these 43 patients we were able to contact 33 by phone. Initial diagnosis was made due to pain in 23 cases, nearly coequal by coincidental examination in 20 cases, for fracture in two cases and for local swelling and bone deformity each time in two cases. Thirty-six patients revealed monostotic and seven patients polyostotic involvement. The following locations were found: three times craniofacial, four times within the spine, eight times at the upper extremity, ten times in the pelvis and 31 times at the lower limb. Two patients were suffering additionally from Mazabraud Syndrome. Actual values at the numeric rating scale regarding pain ranged from 0 to 9 with a mean value of 1. Specific in the polyostotic group we found an average value of 3 and three of seven patients stated a value greater than 5 for persistent pain. Five patients with polyostotic involvement were treated with bisphosphonat for pain control with good response.

It is remarkable that patients with polyostotic involvement have marked higher values for pain intensity at the numeric rating scale. So therefore we should have a closer look for potential reasons explaining that fact. In accordance with previous published studies we found that pain decreased by intermittent intravenous application of bisphosphonates.


R. D. Barr

Disease-free survival and local relapse rates in patients with malignant bone tumors are similar following limb salvage and amputation. However, while there has been considerable interest in comparative function after surgery, as assessed by clinicians, there is less information on patient-reported outcomes (PROs). Interest in PROs has evolved from recognizing the usefulness of measures of (health-related) quality of life (HRQL) and the acceptance that the “gold standard” in such assessments is provided by the individual reporting on his/her own health status.

In the context of cancer and cancer-treatment, the importance of PROs is firmly embedded in the conduct of clinical trials, as documented by the Cancer Outcomes Working Group of the National Cancer Institute (NCI) in the USA. The NCI has promoted the development of appropriate instruments for eliciting and evaluating PROs through the Patient Reported Outcomes Measurement Information System (PROMIS). Similar initiatives have been undertaken in Canada, the United Kingdom, Western Europe and elsewhere. This topic was the subject of a series of reviews in a recent issue of the Journal of Clinical Oncology.

Large studies in the United States and Canada revealed that, among survivors of cancer in childhood and adolescence, those who had had brain or bone tumors experienced the greatest compromise in physical performance, psychosocial outcomes and HRQL.

Inclusion of PROs and measures of HRQL are still not routine in the design and conduct of clinical trials, and these are seldom used in regular day-to-day practice by clinical oncologists who have yet to be sufficiently persuaded of the added value provided by such determinations.

However, the orthopedic community lead the way more than 25 years ago with an assessment of HRQL following treatment of sarcomas of the extremities (at that time refuting the commonly held belief that any therapy, no matter how “aggressive”, was better than limb amputation). That study enrolled only a small number of patients and the therapeutic (especially surgical) options have changed substantially in a generation, but a “marker” was established and the challenge to provide current evidence remains.

Measures of HRQL that focus on orthopedic problems have been developed and subjected to recent rigorous review. But assessments are subject to many confounding factors such as age, gender, diagnosticdetails (tumor type, size and location), prior (neo-adjuvant) and subsequent therapy, the era of treatment and the time elapsed since surgical intervention. Sample sizes will need to be very large to address these variables.

Despite the almost consistent problem of small samples, some common findings emerge. Females experience poorer outcomes than males; there can be improvement over time; and, insofar as they are comparable (candidates for amputation are seldom candidates for limb salvage surgery), the differences in HRQL among amputees, patients who had rotationplasties, and those who underwent limb salvage (with endoprostheses or bone grafts) are small.

Measures of functional outcome and HRQL are neither fully inter-changeable nor mutually exclusive, and much remains to be learned from the measurement of PROs in patients with bone and soft tissue sarcomas.


P.A. Daolio S. Bastoni R. Zorzi F. Lazzaro A. Parafioriti S. Mapelli

Limb salvage has become the most important treatment for patients with malignant bone tumors of the lower limb. Reconstruction with endoprosthesis of the proximal femur and distal femur and proximal tibia is now the most common solution. The data of 180 consecutive patients with malignant bone tumors of the lower limbtreated between 4/1987 and 11/1998 were reviewed. The average follow up is of four years.

129 patients had surgery for primary bone sarcoma, six for aggressive GCT and 45 for metastatic carcinoma. 63 patients were reoperated for different complications. The main complications were: local recurrences in 10 patients, infection in 12 patients and mechanical complications in 35 patients. 28 patients were operated two times and 24 patients more than two times.

14 patients have undergone amputation: six because of local recurrences, four because of infection, and two for post-surgical ischemia.

Eight of the 12 infections occurred after a re-operation.

35 patients had mechanical complications: 14 patients were reoperated to replace the polyethylene bushings in of the first model of HMRTS prosthesis (Howmedica), five patients had ruptures of the femoral stem, three patients suffered mobilization of the tibial stem and two of the femoral stem, six patients required a patella prostheses for local pain.

Two patients had acetabulum wear and three had hip dislocation.

In our experience endoprosthesis reconstruction after resection of bone tumors of the lower limb is a feasible procedure for limb salvage. We must consider that more than 30% of these patients will be re-operated for different complications and that 50% of infections occours after a new surgical procedure.


P. Ruggieri E. Pala C. N. Abati T. Calabrò E. Pignotti M. Montalti A. Ferraro M. Mercuri

Between 1983 and 2006 at Rizzoli 669 knee modular uncemented prostheses were implanted after resection of the distal femur, total femur or proximal tibia. These prostheses include 126 KMFTR prostheses and 543 second generation HMRS prostheses. Patients were followed periodically in the clinic. Data was obtained from clinical charts and imaging studies with special attention to major complications requiring revision surgery. Revision for polyethylene wear was considered a minor complication, since it did not imply failure of the implant. Functional results were assessed according to the MSTS system. Since data could be misleading due to deaths in an oncologic population (although 2/3 of patients were cured or long survivors), to censore the implant unrelated events Kaplan-Meyer curves of implant survival were studied.

In 126 KMFTR group infection rated 13.5%, stem breakage 13%, aseptic loosening 9.5%; change of polyethylene rated 44%. In 543 HMRS prostheses infection rated 8.6%, stem breakage 3%, aseptic loosening 4.8%; revision for polyethylene wear rated 9.6%. Techniques of revisions and their outcome analysed showed about 2/3 of good results, but increased risk of further complications in revised implants. Functional results (MSTS system) were good or excellent in 80% of KMFTR prostheses and in 90% of HMRS.

Decrease of major complications in newer prosthetic design was statistically significant and possibly due to newer materials and modified stem design. Polyethylene wear also decreased significantly. Function was satisfactory in most patients without complications for both groups. Revision surgery is technically demanding and appropriate timing of revision is crucial, since early treatment can improve final outcome.


M. van den Besselaar S.S. Lim P.D.S. Dijkstra A.H.M. Taminiau

Limb-sparing surgery has become the preferred surgical treatment of malignant bone tumours of the knee. In patients with intra-articular extension of their tumour, extra-articular limb sparing surgery can prevent the knee from amputation. In a retrospective study between January 1985 and December 2007, we performed 34 extra-articular tumour resections of the knee-joint for a bone- or soft tissue tumour in the distal femur or proximal tibia with (suspect) intra-articular tumour extension into the knee on MRI. Contra-indications were extension of the tumour into the extensor mechanism and/or tumour involvement of the neurovascular bundle. Osteosarcoma (23/34) was the most common primary malignancy. Mean age was 36 years (17–70) and the mean follow up was 9 years (1–19).

Patient survival rates at 5 years and 10 years are 78% and 58% respectively, mean patient survival was 47 months (8–211). In 12 (35%) patients, the primary implanted prosthesis failed during follow up. Prosthetic survival rates including minor revision surgery were 63% at 5 years and 36% at 10 years. Six (18%) patients had local recurrence of their malignancy, 5 of them in the popliteal fossa. Local recurrence was significantly correlated with marginal margins (P< 0.05). Fifteen patients had major complications (44%) mainly deep infection in proximal tibia resections and aseptic loosening in distal femur resections. Aseptic loosening was significantly correlated with non HA-coated stems (P< 0.05). Functional outcome scores according to MSTS (mean 81, (65–93)) and TESS (mean 85, (56–98)) of survivors are good.

Our results suggest that extra-articular tumour resections of the knee-joint can provide a functional endoprosthesis and can be an alternative for primary amputation. However it is a technical demanding procedure with acceptable local recurrence and high complication rates in patients with, in general, poor survival.


M.D. Aliev M.N. Orekhov S.A. Saravanan D.V. Nisichenko P.S. Sergeev A.A. Babalaev V.A. Sokolovskiy

The aim of this study was to analyze the frequency and reveal the most common reasons of the endoprosthetic instability in patients with malignant bone tumors. From 1992 – 2008, 625/515 patients, endoprosthetic replacement of major joints were performed. The median age of the patients was 30.3 years (13 to 72 years).

Aseptic instability was observed after 3/71(4.2%) humeral joint replacement out of total operations at this location, after 4/80 (5%) hip prosthesis, after 19/133 (14%) proximal tibial prostheses, after 44/299 (14.7%) distal femoral prostheses and after 2/37 (5.4%) total femur replacements.

The retrospective analyses has shown that the reasons of instability were the following: aseptic loosening of the stems of endoprosthesis in 26 cases (24.4%), stem break in 31 (36.1%), endoprosthetic unit destruction in 10 (11.6%), untwistment of fixational screws in 10 (11,6%), migration of hip endoprosthesis components in 2 (2.3%) and endoprosthesis dislocation in 12 (14%). The timing of endoprosthetic instability ranged from 7 days to 12.2 years (average 26.2 months). Statistic analyses was performed in a group of patients with aseptic endoprosthesis instability developed after proximal tibia and distal femur resection.

We conclude that the most frequent reason of aseptic instability was endoprosthetic stem break. The instability rate was actually lower among the patients who had underwent 5–10cm distal tibia resection comparing with the group of 10–15cm bone mass resection (p=0.05). Femoral resection enhanced the instability frequency comparing with proximal tibia resection in the group of 5–10cm bone mass resection (p=0.05).


G. Scoccianti D.A. Campanacci G. Beltrami P. De Biase P. Caldora R. Capanna

Different techniques were proposed for reconstruction after distal radial resection for bone tumors. When not dealing with heavy workers or complex revision cases, a motility preserving procedure can be used. From 1999 to 2007 we performed a reconstruction with an ostearticular allograft in 18 patients.

Age of the patients ranged from 13 to 56 years. Histotypes were: giant cell tumor in 16 patients, Ewing sarcoma in 1, osteosarcoma in 1. Neadjuvant chemotherapy was used in Ewing and osteosarcoma patients. Length of resection ranged from 5 to 13 cm. An accurate host-graft capsulorraphy was performed to reestablish joint stability; no adjunctive distal radioulnar stabilization procedures were used. In one case the procedure was performed after a failed previous graft-arthrodesis; in this case also a proximal row carpectomy was performed.

Non-union of the allograft occurred in 2 cases. In one case autologous cancellous bone grafting from the iliac crest was performed. In the second case the patient due to mild symptoms has till now refused further surgery.

No septic complications occurred.

One patient presented a fracture of the allograft; a revision procedure was performed with a new allograft but also the second graft failed and an arthrodesis was performed. This was the only complete failure of our series.

Follow-up ranged from 20 to 103 months. No recurrences (local or distant) were observed. The patients were evaluated with radiographic and clinical examination. Functional evaluation was performed using ISOLS-MSTS score, a wrist-specific functional score (PRWE) and a comprehensive evaluation of upper arm function score (DASH).

The oncological and functional results in our series highlight that a functional wrist can be restored with an osteoarticular allograft after distal radial resection for bone tumors. Deterioration of the results could occur in the long-term and thus further monitoring with a longer follow-up is needed.


P.T. Funovics F. Bucher R.I. Kotz M. Dominkus

Parosteal osteosarcoma is an uncommon tumour. Different methods of surgical treatment have been reported. Aim of this study was to investigate differences in outcome after biological and prosthetic reconstruction.

Since August 1969, 28 patients have been treated at our institution. Average age was 26 years, range 15 to 59 years. Patient data was retrospectively reviewed within the prospective database of the Vienna Tumour Registry. Average follow-up was 133.9 months, range 8.4 to 382.6 months. Two patients died of disease 8.4 and 81.4 months after operation, respectively, another patient died due to unrelated causes 330.4 months postoperatively. All surviving patients were followed for a minimum of 3.6 months.

Location of the lesion was the distal femur (19), proximal humerus (four), proximal tibia (three), mid-diaphyseal and proximal femur (one each). In 12 patients endoprosthetic reconstruction was indicated. Biological reconstruction was performed in 11 patients. Three patients underwent rotationplasty, two patients were amputated. Eight of 12 patients with endoprostheses have been revised, five have had multiple revisions. Causes for revision were bushing wear (four), aseptic loosening (four), infection (three) and periprosthetic fracture (one). There was no local recurrence in the endoprosthetic group. Two of 11 patients with biological reconstruction underwent revision due to pseudarthrosis and femoral fracture, respectively. There were two cases of local recurrence requiring secondary amputation. Two patients with rotationplasty underwent revision for wound healing disturbance and thrombectomy, respectively. Three patients developed lung metastases, leading to death of disease in two cases of amputation and rotationplasty. One patient with endoprosthetic reconstruction was alive 129.0 months after pulmonary metastasectomy. Functional outcome was satisfactory in all patients; there were no significant differences between patients with endoprosthetic or biological reconstruction.

Biological reconstruction showed less revisions compared to endoprostheses, however, exact preoperative planning is required to obtain clear margins of resection.


MP. Henrichs M. Balke H. Ahrens A. Streitbuerger T. Budny G. Gosheger J. Hardes

A revision of a first generation KMFTR prosthesis due to stem breakage is a problem oncologic surgeons are regularly faced with. We designed an adapter which allows us to connect new MUTARS components to the original KMFTR devices. Thus it is possible to bypass an exchange of the whole prosthesis.

We used this adapter in 10 patients. Time of revision was in average 16.6 years after primary implantation of the KMFTR prostheses. Reasons for revision were femoral stem breakage (n = 5), breakage of the tibial component (n = 3) and periprosthetic fracture (n = 2, one femoral, one tibial).

The femoral stem (3 cases) and the tibial stem (2 cases) as well as the tibial plateau and body (2 cases) could be replaced by MUTARS parts and conjoined with the remaining KMFTR devices. Three cases were converted to MUTARS total femur.

Postoperative complications were one aseptic loosening and one cone-dislocation. Pre-incidence function was restored in all cases. The average Musculoskeletal-Tumour-Society-Score was 82.9% of normal function.

The results show that the new adapter facilitates to restore pre-incidental extremity function by performing a relatively modest revision.


B. Lehner S. Kinkel F. Zeifang D. Witte

Following resection of primary malignant bone tumours of the humerus, limb salvage can be performed by vascularized fibula graft for reconstruction of large segmental defects.

In 12 patients with malignant bone tumour of the proximal humerus, tumour was resected and the bone defect reconstructed by vascularized fibula graft. Median age of the patients was 23 years. Median follow up was 114 months.

In 10 patients humeral head had to be resected and was replaced by fibular transplant including head and shaft of the ipsilateral fibula. Humeral head could be left in place in 2 patients. Median length of transplant was 17.2 cm. Radiographic union could be seen after 8 months in median. In 7 patients partial necrosis of the fibular head occurred, in 4 patients fracture of the transplant happened following trauma. In these 4 cases revision surgery was required. Partial necrosis of the head of fibula had no significant influence on shoulder function. One patient died of disease, the others are disease free. Enneking Index was 61% in median at time of last follow up. At donor side 3 cases of transient peroneal palsy could be seen.

We conclude that vascularized fibula graft is a successful surgical procedure for upper limb salvage especially for preservation of joint function also in long term follow up.


P. Ruggieri E. Pala G. Ussia A. Angelini C. N. Abati T. Calabrò E. Pignotti R. Casadei M. Mercuri

From October 2003 to September 2007 at Rizzoli 161 GMRS® prostheses were implanted after resections of the lower limb. This is a modular system with a knee rotating hinge mechanism, cemented and uncemented stems, in titanium and chromium-cobalt-molybdenum, curved and straight-fluted, with or without hydroxyapatite coating. Adaptors are available to revise HMRS® prostheses with hybrid implants. This study includes 88 males and 73 females ranging in age from 9 to 80 years. Sites of reconstruction were 109 distal femurs, 19 proximal femurs, 1 total femur and 32 proximal tibias. There were 149 oncologic and 12 non oncologic diagnoses, including 96 primary reconstructions and 65 revisions for failures of previous reconstructions. Analysis of imaging and complications was performed and function assessed according to MSTS system. Kaplan-Meier curves were used to statistically evaluate implant survival.

At a mean follow up of 2.5 yrs. 106 patients are continuously NED, 31 NED after treatment of relapse, 7 AWD, 5 DWD. There were 10 major complications: 8 infections (4.7%) (5 in primary and 3 in secondary implants) and 2 aseptic loosenings (1.2%) (1 each). There were 9 minor complications requiring minor revisions. Comparative statistical analysis of implant survival showed no statistically significant difference between primary and secondary implants. Functional results were good or excellent in 95% of patients, without any poor.

Middle term results are promising with no breakages of implant components. Besides oncological cases, there are selected indications in non oncological settings, such as revisions of prosthetic or allografts failures. While a higher complication rate was expected in secondary implants, statistical analysis shows similar survival.


A. Longhi G. Bacci C. Ferrari P. Picci S. Ferrari

Prolonged survival have been reached in the last two decades in patients with Ewing’s sarcoma due to combination of chemotherapy and radiotherapy.

We report the analysis of 493 patients treated according to 4 different protocols in 23 years (Jan1983- Dec 2006).Aim of this study was to evaluate the occurrence of late toxicities as Second Malignant Neoplasms (SMN), Cardiomyopathies and sterility.

Methods: We reviewed our database to find out all those patients aged from 1 to 40 yrs with localized Ewing’s sarcoma who were treated with chemotherapy according to 4 different protocols from 1983 to December 2006. Data were updated at Dec 2008

Results: 493 patients had adequate follow up and meet the eligibility criteria. Median age was 16 yrs (1–40) female/male: 183/310.Median overall survival 69 ms (4–302).220 patients died and 273 are alive. 44 pts received HDCT + PBSCR.Eleven SMN were found : 2 AMLeukemia, 2 parotid adenocarcinoma, 1 melanoma, 1 thyroid cancer and 5 radioinduced osteosarcoma. The interval between Ewing’s sarcoma diagnosis and leukaemia diagnosis was shorter then interval between Ewing’s sarcoma and RT osteosarcoma. Six patients reported a Cardiomyopathy : in 4 cases it was mild and pts are well compensated,2 patients needed heart transplant,. One of these two pts received also a kidney transplant due to chronic renal failure due to previous chemotherapy. Fertility: 17 women became pregnant after chemotherapy, 20 women experienced postTx amenorrea: 7 pts received RT in pelvic area, 9 did HDCT, 3 pts were over 30 yrs old. 9 male became father. 8 male patients did sperm analysis 3 azospermia, 4 oligospermia and 1 normal sperm count. No congenital abnormalities in offsprings were reported.

Conclusions: In this casuistic the Cumulative Risk to have a SMN at 5 yrs is 1.8% and 2.9% at 10 yr. The SMN cumulative incidence in Ewing’s sarcoma seems to be lower then in our previous casistic in osteosarcoma patients (ASCO 2006).


K. Gokaraju J. Miles S. Cannon TWR. Briggs G. Blunn

Following resection of tumours in the distal femur, reconstruction with joint-sparing prostheses have shown good short-term functional outcomes. There is however limited literature on the affect of knee-sparing prostheses on function of the distal femoral physis in children of bone growing age.

We discuss two patients, a male (11yrs) and female (10yrs) who had joint-sparing distal femoral prostheses inserted for treatment of Ewing’s sarcoma. The knee joint, along with the distal growth plate, was preserved and fixed to the distal end of the prosthesis using uni-cortical screws positioned distal to the physis. In the female, these screws were removed 6 months postop due to prominence of the screws under the skin. In both patients, we assessed radiographs from immediately post[surgery and the most recent follow-up (20 and 28 months respectively). In each set, for the operated limb, we measured the height and width of the distal femoral epiphysis, the total length of the femur and the length of the proximal femoral bone segment from the femoral head to the proximal bone-prosthesis interface. In addition, postoperative assessments of leg lengths, bilaterally, were documented.

In both patients, distal femoral epiphyseal height and width in the operated leg showed no significant change following endoprosthetic replacement. In the female, growth did not resume even after removal of the epiphyseal screws. In both patients, lengths of the femur and the proximal bone segment increased significantly following surgery. The patients demonstrated no clinical leg length discrepancy at the most recent follow-up.

This study suggests that the function of the distal femoral growth plate ceases following insertion of joint-sparing distal femoral endoprostheses, probably due to trans-physeal fixation. This does not appear to resume following early removal of distal screws. The proximal growth plate, however, continues to function adequately enough to maintain symmetry in overall leg length.


B.G.I. Spiegelberg M. Sewell M.T.R. Parratt K. Gokaraju W. Aston S.R. Cannon T.W.R. Briggs

The proximal tibia is the second most common site for primary bone tumours. As a result of simultaneous advances in chemotherapy, surgical and biomechanical techniques limb salvage is now a practical option. We report the clinical and functional outcomes of eight patients who underwent limb salvage with a new form of endoprosthetic proximal tibial replacement that allows preservation of the knee joint.

A retrospective, case series of 8 patients who underwent joint sparing proximal tibial replacement between 2004 and 2008. There were 2 males and 6 females with a mean age of 28.9 years (8–43) with overall mean follow up of 35 months (4–48). Functional outcomes were assessed using the Musculoskeletal Tumour Society (MSTS) rating score and revised Oxford Knee Score (OKS)

Five patients had osteosarcoma, one patient had malignant fibrous histiocytoma, another adamantinoma and the final patient had Ewing’s sarcoma. All patients had complete tumour excision, neoadjuvant chemotherapy and to date there have been no distant metastasis. One patient however required a below knee amputation through the prosthesis due to local recurrence at the distal bone/prosthesis interface. Another patient fell at postop day 8 and fractured through the tibial metaphyseal bone requiring ORIF; this healed in extension and ultimately required revision to a proximal tibial replacement 20 months later. Mean MSTS and OKS for the remaining 6 patients were 77% (57–90) and 40 (36–46) respectively.

Limb salvage preserving the knee joint is an effective alternative to a proximal tibial replacement when the metaphyseal bone is tumour free. The joint sparing prosthesis has a favourable functional result when compared to the joint sacrificing prostheses. Retaining the native joint improves functional outcomes and reduces the peak loads through the prosthesis. There was no short-term evidence of loosening. Further follow up is required to ascertain the long-term outcomes of this new prosthesis.


M. Chowdhry R.J. Grimer L. Jeys S.R. Carter R.M. Tillman A. Abudu

Malignant tumours of the radius compose only 3% of all upper limb tumours. Owing to their rarity they are often difficult to manage satisfactorily. Of the options for fixation available, endoprosthetic replacements have been scarcely utilized despite their success in limb preservation with malignant tumours in other parts of the body. At our centre we have used these when biological solutions (eg fibula graft) were not indicated due to extensive disease or the need for radiotherapy.

We performed four endoprosthetic replacements of the distal radius in three males and one female with ages ranging from 19–66 years (average= 42.25 years of age). Two were performed for varieties of osteosarcoma (parosteal and osteoblastic osteosarcomas), one for a large destructive giant cell tumour (GCT) and one for destructive renal metastases. Three were right sided (75%) and one left sided (25%).

Medical records were evaluated for information on local recurrence, metastases, complications and functional outcome using the Toronto Extremity Salvage Score (TESS). Follow up ranged from 22 to 205 months (average= 116.5 months). The average TESS score was 58.1% (range= 44.6–74.5%). Neither case of osteosarcoma recurred. The GCT recurred twice and the patient with renal metastases had nodules removed from his affected wrist on two further occasions. There were no cases of infection, but the two earlier cases had problems with metacarpal stems cutting out and jointsubluxatinos. The two earlier cases have since died at 205 (parosteal osteosarcoma) and 189 months (GCT) respectively of other disease.

We conclude that although this is a very small series of endoprosthetic replacement of the distal radius, the technique is a useful addition to the surgical options, with acceptable postoperative functional results and complication rates when a biological solution or preservation of the wrist joint is not indicated.


S.S. Lim P.D.S. Dijkstra M. Van den Besselaar P. Bekkering A.H.M Taminiau

A retrospective study focusing on long-term follow up of 28 patients with a malignant bone tumour in the distal femur was conducted. Patients with a mean age of 50 (18–90) were clinically and radiologically followed-up for a mean period of 64 months (7–144). Osteosarcoma was the most common primary bone tumour, occurring in 15 patients. The 5-year survival for all patients was 80,9%. At final follow-up, 19 patients were still alive and had a mean follow up of 74,6 months (7–137).

Clinical evaluation was done with the MSTS questionnaire (mean score: 70,0 (26,7–93,3)) and the use of the TESS (mean score: 82,5 (45–99,2) and SF-36 (mean Physical Component Score (PCS): 46,6 (27,1–56,5), mean Mental Component Score (MCS): 53,7 (range 37,0–62,1) was introduced

There were 12 complications: 5 aseptic loosenings, two deep prosthetic infections, two luxations, one prosthetic fracture and two fissures. Six failures were re-operated. An overall prosthetic survival at 5-years of 77,0 % was found. A total of eight (29%) prostheses were considered to have failed after a mean follow up of 27,4 months (0–97). Risk factors in failure of the prosthetics were: non HA-coated stem and top stem-ratio > 1.2. Not length of the endoprosthesis and base stem-ratio. The top-ratio had a mean value of 1,14 (1,00–1,52) and for the four patients with an aseptic loosening the mean top-ratio was 1,23 (1,12–1,51) which was significantly different (p< 0,05 Mann-Whitney U test).

Our results suggest that of the MUTARS endoprosthesis has a good 5-year survival.

The use with a HA coating is preferable. The use of a stem-cortex ratio (> 1.2) at the top of the prosthetic stem can be predictor for aseptic loosening. The addition of the TESS and SF-36 scores give more insight information in how patients undergo their disease: half do not feel disabled.


P. Cuomo D.A. Campanacci G. Beltrami G. Scoccianti P. De Biase L. Sensi R. Capanna

Proximal tibia reconstruction after oncologic resection is challenging due to bone stock and extensor mechanism restoration.

From 1997 to 2007 19 patients (mean age: 39±16 years old) underwent proximal tibia oncologic intra-articular resection with wide margins. Primary diagnosis included giant cell tumor, osteosarcoma, chondrosarcoma and a failed osteoarticular allograft in 10, 4, 3 and 2 patients respectively. Tibial resection length was 10.4±3.4 cm in 18 knees. In one patient with chondrosarcoma the entire tibia was resected. Three patients received preoperative and postoperative chemotherapy, one only postoperative.

Reconstruction was performed with an allograft-prosthesis composite implant and direct suture of the host patellar tendon to the allograft one. Fresh frozen allograft and modular Link prosthesis were used for reconstruction. Five to six weeks of knee immobilization in extension followed the operation. A transient peroneal nerve palsy was observed in three patients. Two patients with a stiff knee underwent an open release after less than one year from index surgery. One patient had a local recurrence from osteosarcoma and underwent an above knee amputation. No patient developed distant metastasis at follow-up.

After 59±37 months none of the patients had implant revision for mechanical complications. One patient had 2-stage implant revision for deep infection. A minor allograft resorption with aseptic drain was observed in one patient who underwent surgical debridement. One other patient had a moderate allograft resorption. Knee flexion was 96±12 degrees. All the patients but two could reach complete knee extension and only two had a minor extensor lag (less than 15 degrees).

In conclusion intrarticular tibia resection and allograft-prosthesis composite replacement ensures satisfactory oncologic and functional results at a midterm follow-up.


O. Vyrva V. Burlaka Y. Golovina I. Shevchenko R. Malik

There are results of our first experience treatment 8 patients who underwent endoprosthetic reconstruction of distal radius after excision of malignant tumors. All patients were treated in Sytenko Institute from 2004 to 2008 and had about 5 years follow-up. There are 3 males and 5 females and the median age at diagnosis was 36 (17–55) years. The resection length measured a mean of 8cm and was measure by radiographs, CT and MRI. Each case was malignant Giant cell tumor. There were 5 cases of primary tumor and 3 cases of local tumor relapse. The patients have had chemotherapy, tumor excision and individual custommade endoprosthetic reconstruction. Unfortunately all patients had one-two surgeries before treatment in our Clinic. We used author’s individual custommade endoprosthetsis which was performed from titanium and ceramic spraying. CT-measurement scale was used for preoperative planning and manufacture this distal radius prosthesis.

One patient has had deep soft tissue infection and we were needed to remove prosthesis. One more patient had proximal radius fracture 4 month after surgery and we performed bone plate osteosynthesis. All patients (except one infection case) have satisfactory wrist range of motion and functional result of upper limb from 10 month to 5 years follow-up.

It is proved that surgical procedure of the tumors of distal radius is a useful and main method of the treatment above-stated localization. The individual custommade prosthesis have a good perspectives for upper limb salvage surgery and reconstruction this area, allowing to receive good oncological and functional results.


A. von Baer M. Schultheiss T. Barth L. Kinzl F. Gebhard R. Mayer-Steinacker

Objective: Modular tumour prostheses are often chosen for the reconstruction of osseous or joint defects following wide tumour resection in limb salvage procedures. In this retrospective trial we were looking for the clinical use in accordance to long-term-follow up especially on aseptic loosening of stem, wear of polyethylene, implant related complications and clinical and functional results.

Methods: From 1996 to 2008 we performed in our clinic in 69 cases a modular distal femur replacement (MUTARS) after wide bone or soft tissue tumour resection.

In our outpatient clinic we have assessed the clinical follow-up as clinical examination (Enneking-score) and standardized radiological follow-up for 5 years, then once per year. In the focus of interest were aseptic loosening of the stems, wear of polyethylene, and mechanical problems as implant failure

Results: In long-term-follow-up 6 polyethylene locks had to be changed into PEEK locks (8,6%9). PEEK-lock complications were not seen in this series. In 5 cases late infection of the prosthesis occured. In another 5 cases aseptic loosening of the prosthesis was diagnosed, fractures of the stems were not seen.

We conclude that in tumour patients with major osseous reconstruction after wide resection a certain loss ob function cannot be avoided, but the rate of complications in the long-term-follow-up after implantation of modular tumour prosthesis is acceptable.


M. Schultheiss A. von Baer M. Arand F. Gebhard T. Barth R. Mayer-Steinacker

Objective: To evaluate outcome parameters after custommade diaphyseal replacement of femur and humerus in long term allograft failures.

Methods: A subset of osteo allograft reconstructions after tumour resection ultimately will fail in patients achieving long-term survival. The reasons for original allograft failure were fractures, osteonecrosis or delayed bony ingrowths and implant loosening (plates, nails).In this study patients had a failed massive allograft after tumor resection of humerus or femur. Alternative surgical approach to revising these reconstructions are endoprosthetic revisions to preserve limb function with minimal complications due to custom made modular diaphyseal replacement systems of femur or humerus, especially with short proximal or distal intramedullary anchoring.

Results: A series of custom made diaphyseal replacement systems of femur or humerus was done in our department demonstrating the feasibility of this technique. Most patients initially were treated because of malignant bone tumors like Ewing sarcoma or soft tissue tumours. Allograft fractures occured up to 49 month after initial tumour resection. The follow up included radiographic and clinical parameters. In all cases limb salvage, good function and pain relief was achieved.

Conclusion: Reconstruction of the diaphyseal aspect of the femur or humerus after failure of osteoarticular allograft with custom made diaphyseal replacement of femur and humerus is a good option to achieve limb salvage, good function and pain relief.


Denis Kovalev Vladimir Kovalev Olga Geludkova Vladimir Strikov Olga Polushkina Maria Pulaewska Irena Borodina

Purpose: Function of the extremity assessment in children and adolescents treated with endoprostheses for bone sarcomas.

Method: We studied the results of the endoprosthetic replacements in 26 patients 5–17 years old (med-12,8) with malignant primary tumors: osteosarcoma (20), Ewing sarcoma (2), chondrosarcoma (3), rhabdomyosarcoma with bone affection (1). The surgeries were provided in 2004–2008 years for the joints: knee (19 – femur (10), tibia (9)), coxofemoral (2), humeral (4), elbow (1). We used non-expandable endoprostheses in 10 patients 13–17 years (med -15,3) and expandable ones in 16 patients 5–15 years (med-1,1): PROSPON (10), MUTARS (14) and REPIPHYSIS (2). Invasive lengthening was held for PROSPON (8 procedures in 5 patients) and noninvasisve for MUTARS and REPIPHYSIS (8 patients). All the patients underwent protocol therapy. The term of observation was 0,5–4,5 years (med-2,1). For low extremity good function was assessed as the ability of walking with ease, equal length of two legs and sufficient artificial joint’s mobility. For upper extremity good function was assessed as the ability of using an arm freely in daily life (including writing and typing), equal length of two arms and sufficient artificial joint’s mobility.

Results: 18 patients (69,2%) are alive. Local relapse had place in 1 (3,9%) case. Good function of an extremity was registered in 14 (73,7%) patients who survived. The best results we saw in noninvasive maintaining equal limb length.

Conclusion: Endoprosthetic replacement in a complex with protocol therapy secures good function of an extremity in children and adolescents with malignant primary bone sarcomas.


H. Ozger M. Sungur B. Alpan A. Kochai B. Toker L. Eralp

Autografts produced by recycling of tumor-bearing bone have been used for bridging intercalary bone defects but they are known to act as massive allografts after recycling procedures due to devitalisation. Recycled bone is superior to massive allografts since it allows anatomical reconstruction. Vascularised fibular grafts are inserted into recycled bone segments to provide biological support and to promote healing.

Twelve patients with a mean age of 13.3 years (6–31), who had undergone curative resection of malignant bone tumor followed by biological reconstruction comprised of recycled bone combined with vascularised fibula, were followed up for a mean period of 16.8 (6–46). The tumor was located in distal femur in 7 patients, proximal femur in 2, proximal tibia in 2 and mid-diaphyseal tibia in 1. Cryopreservation with liquid nitrogen was employed for all patients. Contralateral single strut vascularised fibular grafts were used in all except one patient for whom bilateral fibula grafts were harvested to span a longer defect. Plates were used for fixation in 11 patients, and intramedullary nailing in one case. Mean length of bony defect was 16.1 cm (9.0–25.0). Mean fibular graft length was 17.5 cm (10.0–23.0 cm).

Complete union and full weight bearing was achieved in 6 patients, and mean time to detect the commencement of union was 6 months (4–8). Incomplete union was detected in 4 patients and no union in 2. Five patients were complicated by implant failure, 1 with deep infection and 1 with drop foot.

In order to fill large defects after resection of bone tumors, recyled bone combined with vascularised fibular graft is an effective reconstructive tool. Union rate of this technique is quite satisfactory with good functional results.


Sh. Tagiyev E. E. Ibragimov

The aim of this study was to analyze complications and functional outcomes after individual and module endoprosthesis.

From 1993 to 2008 in our clinic 42 patients with bone sarcomas were treated with resection and endoprosthetic reconstruction of large joints. In 29 patients we have applied individual, in 13 patients module prosthesis. We have assessed complications and functional results. For individual prosthesis: pyoseptic complications-4 (9,52%) pts, orthopedic events-9 (21,43%) pts, local recurrences-5 (11,90%); functional results: “excellent”-10,34% (3/29), “good”-48,28% (14/29), “satisfactory”-24,14% (7/29), “non-satisfactory”-17,24% (5/29). For module prosthesis: Only in one patient local recurrence has been observed. Functional results are so: “excellent”-23,1% (3/13), “good”-69,2% (9/13), “satisfactory”-7,7% (1/13), “non-satisfactory”-0.

We conclude that using of module endoprosthesis allows achieving good functional results with low rate postoperative complication.


H. Ozger B. Alpan M. Sungur A. Kochai B. Toker L. Eralp

In an era where the survival rates of oncologic patients are improving, biologic reconstruction is the treatment of choice, however, it has its complications and fortunately we have the solutions.

Biological reconstruction was performed on 52 patients with a mean age of 11.3 (1.5–16) after malignant bone tumor resection in our institution between 1991 and 2008. Patients were followed up for a mean period of 49 months (3–216). Twenty-nine patients were diagnosed with osteosarcoma, 22 with Ewing sarcoma and 1 with adamantinoma. A wide range of vascular and nonvascular autografts, allografts, fibular transposition, bone regeneration and bone recycling techniques were utilised alone or in combination for reconstruction. Crucial anatomical parts (epiphyses, apophyses, triradiate cartilage, glenoid) were preserved in 41 patients while maintaining safe surgical margins.

Wound problem was the most common early complication. The most common late complications were nonunion, limb length discrepancy, limitation of range of motion (ROM), deformity, implant or external fixator failure and fibular graft fracture. Local recurrence was seen in only 2 patients. Patients underwent a mean of 0.8 (1–10) additional surgical interventions for treatment of complications. Thirty-one out of 43 lower extremity patients became ambulatory with full weight bearing and near full ROM while 4 died of disease and 2 were disarticulated prior to healing or treating of complications. Six patients with reconstructions around the glenohumeral joint had functional outcomes varying from excellent to poor with defect pseudoarthrosis. Two patients with successful pelvic reconstructions suffered from co-morbidities and disease itself. Implants and fixators, orthoses, physiotherapy and antibiotherapy were used as necessary for treatment of complications.

Biologic reconstruction yields good functional outcomes and allows more flexibility while treating complications since it preserves bone stock and epiphyses.


R. Zorzi S. Bastoni P. Daolio F. Lazzaro P. Zacconi M. Laccisaglia S. Mapelli

Conservative treatment of neoplastic bone lesions in paediatric patients may require the sacrifice of growth cartilage with subsequent hypometria or axial deviation of the lower limb.

Segmental reconstructions can be made using acrylic cement and intramedullary nailing or allograft. In case of involvement of the joint, reconstruction can be performed with prosthesis or arthrodesis.

These reconstruction techniques can lead to a progressive deformity associated with shortening of the limb.

The resolution of legs discrepancy and axial defects in survived patients often requires more than one surgical procedure.

In our Institute, the patients affected by aforementioned defects, are treated with axial or circular external fixator at completed skeletal growth.

This paper refers complications and outcomes in five patients treated:

1st case. Male, 10 years: osteosarcoma of the distal femur healed with residual shortening of 8 centimeters.

– We proceeded with a double level lengthening (proximal femur and proximal tibia) using Ilizarov technique.

2nd case. Female, 8 years:distal femur osteosarcoma healed with a shortening of 6,5 centimeters.

– We used the Ilizarov apparatus to achieve an elongation of cm. 7 on soft tissues allowing the subsequent bone replacement with allograft of appropriate length.

3rd case. Female, 9 years: Ewing sarcoma of the femoral shaft. The correction of the legs discrepancy (8 centimeters) was performed using the Ilizarov apparatus with a proximal tibial corticotomy.

4th case. Female, 11 years: distal femur osteosarcoma healed with residual shortening of 8 centimeters.

– A gradual lengthening of soft tissues with recovery of the length leg allowed the insertion of a new allograft associated with vascularised fibula.

5th case. Male, 13 years: femoral fracture in fibrous dysplasia. Residual leg discrepancy of 5 centimeters treated with tibial lengthening by a proximal corticotomy and use of the Ilizarov apparatus.

The results obtained in our patients show that the use of the external fixator increases the quality of life in long-term survivors.


A. Luzzati K.D. Schaser M. Alloisio G. Perrucchini C. Reinhold I. Melcher W. Schmoelz A.C. Disch

Introduction: Total en bloc spondylectomy (TES) as the only radical treatment option for sarcoma and solitary metastases of the spine was shown to markedly minimize local recurrences, improve patient quality of life and substantially increase overall survival rates. Due to surgical difficulty of TES and complex biomechanical demands in defect reconstruction multisegmental tumor involvement of the spine has long been considered as a palliative situation, exceeding the limits of surgical feasibility. Thus, multilevel resections reports are very rare. For the first time, this study analyzes the onco-surgical results after multilevel thoracolumbar TES and reconstruction with a carbon composite vertebral body replacement system (CC-VBR) in a collective of patients.

Methods: 18 patients (9f/9m; age 52±14y) treated with thoracolumbar multilevel TES (6x2, 9x3, 3x4 segments) for spinal sarcomas (n=9), solitary metastases (n=5) and aggressive primary tumors (n=3) were retrospectively investigated. According to the classification system of Tomita et al. all patients were surgically staged as type 6 (multisegmental/extracompartimental). Defect reconstruction (11 thoracic, 3 thoracolumbar and 4 lumbar) were performed with posterior stabilization and a CC-VBR. Patient charts and the current clinical follow-up results were analyzed for histopathological tumor type, pre- and postoperative data (symptoms, duration of surgery, blood loss, complications, intensive care, adjuvant therapies etc.) and course of disease. Latest radiographs and CT-scans were analyzed at follow up. Oncological status was evaluated using cumulative disease specific and metastases-free survival analysis.

Results: With a mean follow up (100%) of 18 (4–44) months 17 patients (94%) were postoperatively ambulatory without any support. Postoperative neurological deficits were seen in one patient (6%). Wide resection margins were attained in 7, marginal in 11 patients. Depending on tumor biology/grading and/or resections margins an adjuvant therapy (radiation/chemotherapy) was performed in 12 (67%) patients. Local recurrence was found in one patient (6%). 13 (72%) patients showed no evidence of disease, 3 were alive with disease while 2 died of disease at 10 and 27 months postoperatively.

Conclusion: In selected patients with multisegmental spinal tumor involvement oncological sufficient resections can be reached by multilevel TES. Although the surgical procedure is challenging and the patient’s stress is considerable our encouraging midterm results together with the low complication rate clearly favour and legitimate this technique. However, treatment success strongly depends on adjuvant therapies. Reconstruction with a CC-VBR showed low complication rates, promising biomechanical characteristics, increased volume for bone grafting and lower artefact rates in follow-up MR- and CT-imaging.


S. Vijayan W. Bartlett R. Lee A. McGrath G. Blunn T.W.R. Briggs S.R. Cannon

The use of massive endoprostheses following bone tumour resection is well recognised. Where possible, joint salvage rather than joint replacement is usually attempted. However cases arise where there is insufficient bone following tumour resection to allow adequate fixation of a joint sparing prosthesis. We reporta series of 4 patients (aged 4–12), treated between 1994 and 2008, in which irradiated autologous bone has been combined with a diaphyseal or distal femoral replacement in order to preserve the native hip joint.

There were 3 cases of osteosarcoma and 1 case of Ewing‘s sarcoma. After a mean follow-up of 53.5 months (range 9–168), all four patients are alive without evidence of local recurrence or metastases. One implant was revised after 14 years following fracture of the extending component of the growing endoprosthesis. There have been no cases of loosening or periprosthetic fracture.

This is the first report of irradiated autologous bone with joint sparing endoprostheses in skeletally immature patients.


M. Başbozkurt Y. Yurttaş C. Yıldız M. Kürklü B. Demiralp

The authors aim to report the long-term follow-up experience in the reconstruction of bony defects by Ilizarov’s distraction osteogenesis using bone transport method following en bloc resection of bone tumors.

En bloc resection was performed nine patients with bone tumors between October 1991–January 2000. The mean age of the patients was 19.3 years. Histological diagnosis was osteosarcoma in four cases, Ewing sarcoma in two cases, giant cell tumor (aggressive) in one, osteofibrous dysplasia (latent) in one and osteoblastoma (aggressive) in one case.

The average follow-up period was 122 months and bone defect after resection was 14 cm. The function of the affected leg was excellent in four patients, good in two and poor in one patient according to the modified system of the MSTS. In the case where reconstruction of the ulna was done, MSTS score was excellent and DASH skoru was 2.5.

We imply that in patients with long life expectancies, reconstruction with distraction osteogenesis seems to be an efficient method in the long-term follow up, on condition that its complications are promptly managed.


H. Wafa W. Ebeid A. Ghoneimy S. Amin

Fifteen patients (11 males, 4 females) with a median age of 16 years (range, 7–25) were treated in our centre by intra-articular resection of the proximal femur, and hip arthrodesis using a vascularized fibular graft. Eight patients had Ewing’s sarcoma, 5 osteogenic sarcoma, and 2 chondrosarcoma.

After a mean follow up of 58.2 months, 13 patients were alive with no evidence of disease. All fibular grafts united at a mean time of 7.6 months (range, 7–9 months). Four patients had stress fractures of the vascularized fibular graft, all healed after a mean period of 6.5 weeks. Failure of the fixation system occurred in two patients. Deep infection developed in one case which necessitated plate removal. Three of these patients with complications underwent a second procedure, giving a re-operation rate of 20%. The mean MSTS functional score was 85.9% at the time of the latest follow-up.

We conclude that hip arthrodesis using a vascularized fibular graft is a viable alternative to endoprosthetic replacement after proximal femoral resections. It should be considered as an effective and durable reconstructive technique in young patients with high physical demands.


M. Pagano R. Manicone M. Berta E. Brignardello A. Corrias F. Fagioli G. Gino E. Garrone A. Postini A. Brach del Prever

From January 2003 a long term follow-up project started for adult patients treated in our Centre for cancer in pediatric age, to evaluate late effects of therapy. For all patients a personalized follow-up was scheduled (time, function-tests, etc).

We analyzed 24 cases of bone tumors: 14 osteosarcoma (OS) and 10 Ewing’s sarcoma (ES). Median age at diagnosis was 13 years (range 11–18) for OS patients, 11.6 years (range 6–18) for ES; 50% males in both groups. All patients were treated according current CNR/ISG-protocols: all OS cases underwent surgery; in 5/10 ES patients local treatment was surgery, in 5/10 radiotherapy; 7/24 received hematopoietic stem cells transplantation (HSCT).

Median age at evaluation is respectively 26.5 years (range 18.7–34) and 23.5 (range 21.6–32); median follow-up is 13 years (range 6–22) and 13.7 (range 6.7–22.3).

Cardiovascular function is normal in all OS cases; 3/10 ES patients developed asymptomatic ejection fraction reduction, currently not treated.

One OS patient underwent bilateral thoracotomy and HSCT for multiple metastases at diagnosis and had a mild lung function alteration. One OS patient developed mild chronic kidney disease, one ES nephrolithiasis. Liver function is normal in all cases.

Height velocity and final height are normal in 10/14 OS and 9/10 ES patients; in remaining 5/24 no growth hormone secretion deficit was found.

One OS patient developed primitive hypothyroidism and one OS benign thyroid nodule with partial thyroidectomy; one patient multifocal papillary thyroid carcinoma with total thyroidectomy at 11 years from diagnosis of ES.

Spermatogenesis deficit is a common find (5/7 OS and 5/5 ES male patients); one female treated with HSCT and radiotherapy for ES pelvic relapse has primitive hypogonadism. No other hypothalamo-hypophyseal-adrenocortical system hormones deficit was found.

We reported no significant neuropsychological alterations nor employment problems: 20/24 patients have a job, 4/24 are students. Three OS females have children.


Y. Goshen L. Kornreich J. Stein S. Ash I.J. Cohen M. Feinmesser I. Yaniv

The detection of hepatic nodules during follow-up of survivors of solid tumors in childhood raises a diagnostic dilemma. Focal nodular hyperplasia (FNH) is an uncommon, benign tumor and must be differentiated from late hepatic metastasis.

We retrospectively analyzed patients, treated for pediatric solid tumors between January 1990 and December 2007, and performed abdominal imaging as part of the follow-up.

Four survivors with FNH were detected, out of 450 who received chemotherapy with/out irradiation including patients who underwent autologous bone marrow transplantation (ABMT). Case 1: A 23 years(y) adolescent, presented at age 10y with acute abdomen due to embryonal sarcoma of liver, she received VACAIEx4, relapsed locally, and underwent ABMT with high-dose carboplatin/melphalan and radiotherapy. Asymptomatic multiple liver lesions were disclosed by US and MRI 5y later, biopsy proved FNH. Case 2: A 21y adolescent who at age 3y had alveolar rhabdomyosarcoma of the calf with positive inguinal nodes. She received VACAIE x6, and VP16/carboplatin x3 with local radiation. She developed ovary disorder and received oral contraceptive (OC) at age 14.5y, routine US 1.5y later disclosed nodular lesions in liver, diagnosed as FNH by CT, pills were stopped. At follow-up some lesions reduced in size and few disappeared. Case 3: A 9y old girl, operated for choroid plexus carcinoma at age 1.5y, received VP16/carboplatin x16 and underwent ABMT preceded by thiotepa/melphalan. Abdominal US at age 5.5y disclosed multiple liver lesions, biopsy proved FNH, that disappeared 2y later. Case 4: An 11y old girl operated at age 8 months for retroperitoneal germ cell tumor, received VIP/BVPx4, routine US at 10y disclosed 2 liver lesions diagnosed by CT as FNH.

We conclude that FNH can be differentiated from late metastasis by imaging; in questionable cases by biopsy, close follow-up is recommended, alkylating agents especially during ABMT, and OC may be risk factors.


Full Access
G. Sys M. De Muynck B. Poffyn D. Uyttendaele G. Vanderstraeten

Detection of local recurrence after sarcoma resection can be impaired by metal implants locally, or by the patient ‘s general condition. Metal implants cause severe distortion and scattering of either MRI or CT data acquisition. Therefore the detection of local recurrences in proximity of heavy metal implants such as prostheses or osteosynthesis material can be difficult. Patient related conditions, e.g. renal insufficiency, allergy, claustrophobia, may completely prohibit the use of contrast media or even a scan itself.

Ultrasound provides several advantages, and can be used for different indications in sarcoma patients. Patient related conditions prove no obstacle for this technique. Currently our indications are local follow-up after soft-tissue sarcoma resection and evaluation of regional lymph nodes, detection of local recurrence of bone sarcoma in proximity of metal implants, and amputation stump evaluation.

We describe a patient study population of 103 patients. Seventeen had only diagnostic and staging ultrasound, four had an evaluation of their amputation stump, 24 were followed after resection of a soft-tissue sarcoma, and 58 were followed by this method after sarcoma resection and implantation of metallic implants. Evaluation modalities are described according to the indications.

Results: We have detected nine local recurrences, and four patients with suspect lymph nodes had a biopsy of which half showed malignant tumour cells. Infection and inflammation around metallic implants can be evaluated, the technique also allowing placement of drains in infected seromas in irradiated regions. It should be emphasised that reliable results can only be achieved if a baseline ultrasound is performed, followed by subsequent studies at regular intervals.


V.V. Teplyakov S.A. Sedyh V.Ju. Karpenko A.V. Buharov

Purpose: estimate efficiency minimally invasive methods of treatment at patients with tumor lesion of bones.

Materials and methods: 145 patients, middle age e 42 years. it has been executed 249 percutaneous vertebroplasty, 15 osteoplasty and 46 radiofrequency thermal ablation Most often minimally invasive methods were carried out to patients with bone metastasis lesion of a breast cancer – 65 (44,8%) and kidneys – 14 (10%) patients.

Results: reduction in a painful syndrome on a visual analog scale after operation is noted at 126 (87%) by patients. Positive dynamics Watkins scale at 119 (82%). Improvement of quality of a life on scale Karnofski at 94 (65%) the patient. Complications after vertebroplasty and osteoplasty in the form of methylmethacrylate leak into the surrounding tissues at 19 (18,5%) patients. At one patient after radiofrequency thermal ablation has developed burn skin. There were three pathological bone fractures after radiofrequency thermal ablation.

Conclusions: vertebroplasty, osteoplasty and radiofrequency thermal ablation – minimally invasive methods of treatment the patients with tumoral lesion of the bones, allowing in short tim stop a painful syndrome, create adequate stability in a bone segment and improve quality of a life of oncological patients.


M. Montalti E. Pala T. Calabrò A. Angelini G. Ussia P. Ruggieri

Osteosarcoma is a common primary bone sarcoma and distal femur its most frequent site. Between 2003 and 2008 at Rizzoli, 66 patients with osteosarcoma of the distal femur had neoadjuvant chemotherapy, resection and reconstruction with modular uncemented mega-prostheses. Series included 37 males and 29 females. Mean follow up was 2 years. To measure “subjective” outcome Karnofsky scale (KPS) was assessed for each patient pre and post-treatment. Also a functional evaluation according to the MSTS system was performed. To find out the current quality of life, a questionnaire on life at work, study and sport before and after treatment was sent to 64 alive patients.

Before treatment 7 patients had a Karnofsky index (KI) of 60%, 31 of 50%, 25 of 40% and 3 of 30%. After treatment 19 patients had a Karnofsky index performance of 90%, 28 of 80%, 11 of 70%, 5 of 50% and 1 of 40%. Two patients died of disease. The most represented index of KPS after teatment was “Able to carry on normal activity; minor symptoms”. Poor results were related with amputation (2), knee stiffness (3), infection (2), aseptic loosening (1). After treatment 91% of patients had a KI over 70%, while 89% a KI lower than 50% pre-treatment. MSTS system showed excellent or good results in 85% and fair or poor in 15% of the patients. Average score at MSTS evaluation was 22 (73%). Questionnaires (some still pending) confirm previous analysis.

KPS is simple and effective in evaluating quality of life in patients treated for distal femur osteosarcoma. In this study it confirmed the satisfactory MSTS assessed results. It is an easy method, useful and accessible for patients. The reported analysis shows that patients treated for osteosarcoma of the distal femur can have a good quality of life.


U. Pirker-Frühauf A. Leithner R. Windhager

High-dose methothrexate, a standard agent in the therapy protocols for osteosarcoma, has long been suspected to have a negative long-term effect on bone metabolism and bone mineral density, especially in children and young adults. Recent literature questioned this association as also the BMD of Ewing‘s sarcoma patients treated without methothrexate is known to be decreased. We therefore wanted to screen our patients treated for Ewing‘s sarcoma and osteosarcoma for osteopenia/osteoporosis-associated fractures.

Between 1994 and 2008 107 patients below 50y of age were treated for bone malignancies including 51 Ewing’s sarcomas – 31 male and 20 female – with a mean age at diagnosis of 17y(±11SD) and 56 osteosarcomas – 36 male and 20 female – with a mean age of 23y(±12SD). We screened the patients‘ files for fractures after chemotherapy.

We found five patients with not trauma-associated fractures – one Ewing‘s sarcoma(1/51;2%) and four osteosarcoma patients(4/56;7%). They presented one fracture of the proximal femur 107 months after tumour diagnosis, three fractures of the distal femur after 29, 51, and 72 months and two fractures of the proximal tibia after 29 and 32 months (one patient suffered from fractures affecting both – the distal femur and the proximal tibia).

As presented in our case series fractures due to an osteoporotic process after chemotherapy for bone sarcomas are well known late effects. Although described in several studies therapeutic recommendations for pro-phylaxis are sparse. Furthermore the fact that fractures occurred in both types of sarcoma casts MTX as the main cause of chemotherapy-induced osteoporosis into doubt. Additionally we estimate a high number of unreported cases of premature osteoporosis because sarcoma patients are usually not tested for their BMD-levels. Therefore further studies using DEXA (dual-energy-x-ray-absorptiometry) to measure the patients BMDs after chemotherapy are needed.


I.C.M. van der Geest H. Knoop G. Bleijenberg H.W.B. Schreuder R.P.H. Veth

Nowadays more attention is paid to the quality of life during and after cancer treatment, and fatigue is an important factor influencing this. Still little is known about the development of fatigue before, during and after cancer treatment and its contributing factors. We analyzed the level of fatigue, pain, anxiety and activity before and after the treatment of benign or low-grade malignant bone and soft tissue tumours in 43 patients. All patients were treated with surgery only. The mean age of the patients was 40 years (range 20 to 67 years). Fatigue severity was measured with the CIS-fatigue questionnaire, where a score of 35 or higher reflects severe fatigue. The VAS score was used to measure pain (0=no pain, 10=severe pain), and the Dutch version of the Spielberger State-Trait Anxiety Inventory to measure state anxiety. Physical activity was measured with an actometer, worn at the ankle for two weeks. All measurements were done before the tumor surgery and twelve months later.

Severe fatigue was seen in 35% of the patients before they had tumor surgery. After 12 months 32% of the patients still was severely fatigued. The mean VAS pain score was 2,3 before treatment and 2,2 after 12 months. The anxiety score lowered from 38,1 before treatment to 33,2 one year later. Actometer scores increased from 57,7 before treatment to 69,9 after 12 months. Fatigue severity correlated with pain and anxiety both before and 12 months after treatment, but not with actometer scores.

In this study we see that severe fatigue is present in 35% of tumor patients before they are treated, and this percentage remains high (32%) until one year after surgery. Since severe fatigue correlated with more anxiety and pain, these symptoms can help us understand and treat severe fatigue in tumor patients better.


D. Freitas A. Vilaça M. Massada A. Pereira P. Cardoso

Osteosarcoma is the most common tumor among the primitive malignant bone tumors. When different features of these lesions are considered, we can find several varieties of this tumor, with distinct anatomo-clinical presentation, treatment and prognosis.

Until the 70s, its prognosis was very poor, the standard surgical treatment was amputation and 80% of the patients died from metastatic disease. With the development of new surgical techniques, the advent of combined chemotherapy and more accurate imaging, the outcome of these patients has improved significantly. Consequently, approximately 90% of the surgical cases are treated with limb salvage procedures.

The authors reviewed 22 cases of Osteosarcoma treated in HGSA, 20 being submitted to the T20 Rosen protocol.

Trocar biopsy was performed in 19 of the patients and 3 of the patients were submitted to incisional biopsy in order to complete diagnosis.

Regarding the anatomo-clinical pattern, Classic Osteosarcoma was present in 19 patients, 2 of the cases were Parosteal and 1 was Central low-grade Osteosarcoma.

The majority of patients underwent limb salvage surgery; only 2 had amputation surgery and 1 patient was submitted to palliative chemotherapy. Considering limb salvage procedures, several techniques were performed: arthrodesis (n=1), grafts (n=4), prosthesis (n=13) and compound prosthesis (n=1). The resection margins were wide in 19 cases, marginal in 2 cases and in 1 case intra-luminal.

Among the treated patients: 12 patients are still alive and cured, 3 have metastatic disease, 6 are deceased and 1 didn’t complete the follow-up.

The final functional score obtained was 84% for the superior limb (DASH) and 81% for the inferior limb (TESS).

Although the scarce number of cases described were not enough to make any kind of correlation, it was possible to establish the accuracy of the multidisciplinary approach involved both in the diagnosis and treatment, in agreement with the “state of art”.


L. Aung S.M. Saw T. Khaing TT Khyne S.S. Nathan E.J. Yeoh T.C. Quah R.W. Pho

Childhood cancer survival has increased dramatically over the last 30 years. Childhood Cancer Survivor Study- SG was established to evaluate the outcome and toxicities experienced by long term childhood cancer survivors in Singapore. There were 429 cases of hematological malignancies (HM) and 342 cases of solid tumors (ST) diagnosed and treated at National University Hospital (NUH) Singapore from May 1981 to December 2007.

There were seven long term survivors for Osteosarcoma (OS) out of 26 patients seen during the study period. Median age at diagnosis was 13.8 (range, 6.4–15.8 years) and median follow-up was 7.9 (range, 2.6 – 13.2 years). Cumulative doses of chemotherapy received included: cisplatin (240 – 800 mg/m2); doxorubicin 150 – 450 mg/m2); methotrexate (16 – 144 Grams/m2); ifosfamide (27–80 mg/m2); and etoposide (1000 – 3300 mg/ m2). According to the NCI Criteria for Toxicity (CTC version 2.0), three patients experiences grade 2 sensorineural hearing loss; three cases of grade 1 cardiomyopathy; three cases of grade 1 renal tubulopathy; and six cases of post surgical complications (infection-3, length discrepancy-3, poor fitting prosthesis-2).

Many of the patients did not have baseline pre-treatment evaluations such as audiograms, renal function, echocardiograms and similar proportion were not adequately followed-up post treatment. This is the first analysis and report in the country on treatment related outcome and toxicity in long-term survivors of childhood cancers such as osteosarcoma and other solid tumors. Authors recommend that future treatment protocols for childhood cancer in Singapore should incorporate pre- and post-treatment evaluations and close follow-up of young survivors with establishment of a multi-disciplinary late effects clinic.


L.P. Khalafova E.E. Ibrahimov S.V. Abdiyeva

Subclinic liver dysfunctions (SLD) wildly spread among adult oncology patients and can negatively influence to results of some oncology patients treatment. But information concerning same problem in children is remain lack.

The purpose of this investigation was the determination of SLD spreading among children with sarcomas of bone and soft tissues and estimation its clinical significance.

Materials and methods: 200 children with sarcomas of bones and soft tissues were involved in the observation (136 boys and 64 girls) in age groups: 2–10 years – 86 and older 10 years – 114. All children were examined with the help of clinic and laboratory methods including biochemical, serologic and immunologic testing of the blood.

Results and discussion: Results obtained if the investigation demonstrated that different degree of the SLD was widely spread among children with sarcomas – biochemical signs of SLD were detected at 26.0% children. Frequency and degree of severity of SLD increased parallel with increasing the clinical stages of sarcomas.

Serological markers of infections caused hepatitis B and C viruses in all children had biochemical signs of SLD were detected in several times frequently than in all children had no above mentioned signs of subclinic hepatopathy.

Presence of SLD signs in children with sarcomas was accompanied with more expressed depression of immunologic reactivity including natural antitumor resistance estimated on the base of natural killer cells’ cytotoxicity.

Besides, presence of biochemical signs of SLD in children with sarcomas was accompanied with more frequent and expressed side-effects of chemotherapy and lower effect of treatment of those children.

Conclusions: 1. SLD spread among children with sarcoma as like as among adult oncology patients. 2. Presence of SLD children with sarcomas has important clinical significance.


L. Kutnikova P. Mudry M. Kyr A. Fabryova J. Sterba

Introduction: Late effects of treatment in pediatric oncology patients are major issues of follow up care. Success in overall survival of patients with Ewing’s sarcoma/PNET (ES/PNET) correlates with cumulative doses of alkylating agents especially. Renal toxicity is subject of interest due to irreversible tubulopathy and need of many concomitant nephrotoxic drugs given during treatment.

Objectivee: Patients suffered from ES/PNET on Euro Ewing 99 protocol were eligible for evaluation of renal functions during therapy and follow up.

Methods: Design ofthis study was single institution observational. Total of 20 patients were included 9 females and 11 males. Renal toxicity was assessed as glomerular filtration rate according to Schwartz’s formula (GFR), serum creatinine (S-crea), fractionated phosphate reabsorption (Tp/Ccrea), daily phosphate waste in urine (U-P), daily protein waste in urine (U-Pr) and minimal signs of Fanconi syndrome (FS; positive urine glucose and/or protein).

Results: Median age at time of diagnosis was 11.7 years. Median follow up from time of diagnosis was 1.2 months. Median dose of ifosfamide was 87 g/ m2. Median GFR decreased from 2.7ml/s to 2.2 ml/s (p=0.001). Median of S-crea was initially 48 μl/l and 58.1 μl/l at time of last follow up (p< 0.001). Median of Tp/Ccrea was 1.2 mmol/l and decreased to 1.1 mmol/ l at the end of treatment (p= 0.026). U-P was initially and finally 11.9 mmol and 25.1mmol, respectively (p = 0.008). Median of tubular reabsorption of phosphate decreased from 95% initially to 90% (p=0.001). Daily waste of protein increased from 0.11 g to 0.43 g (p= 0.051). Minimal signs of FS developed in 9 of 17 patients (53%).

Conclsions: Patients with high cumulative doses of ifosfamide are at risk of renal impairement. Despite statistically significant differences of severeral measures observed in this study, clinical impact of post treatment values does not exceed grade 1 toxicity. Observation of minimal signs of FS developed in 53% of patients is of concern and further treatment of ES/PNET should be carefully focused on late effect too.


L. Aung T.T. Khyne S.M. Saw T. Khaing S.S. Nathan E.J. Yeoh T.C. Quah R.W. Pho

Childhood long-term survivors now experience significant late effects from the primary cancer itself or from therapy. Cisplatin, an alkylating agent used in treatment for osteosarcoma, has been associated with irreversible high-frequency sensorineural hearing loss. There were 27 osteosarcoma patients treated at Department of Pediatrics, National University Hospital from 1997 to 2005. Twelve of these were long-term survivors, i.e. survived more than 2 years from initial diagnosis.

Pre-chemotherapy audiogram was performed in 50% (n=6) of patients and the audiogram results were not available in the remainder (n=6, 50%) as it was either not done or records were not available. Prior to year 2003, Cisplatin was administered at a dose of 100mg/ m2/course (EOI regimen) in 50% of cases, and after year 2003, 120mg/m2/course (T12 regimen) in 45%. Median cumulative dose of cisplatin was 550mg/m2 (cumulative dose range, 240 – 800 mg/m2). Out of 12 patients, 7 patients (58%) experienced cisplatin induced ototoxicity. According to NCI Toxicity Criteria, Grade I ototoxicty was observed in two cases (30%), grade 2 toxicity in five cases (70%), and bilateral sensorineural hearing loss was noted in six of the survivors. One long term survivor required a hearing aid. Six of them had and renal tubulopathy (NCI Toxicity Grade 2) was noted simultaneously in 35% of cases (n=4).

The incidence of cisplatin induced ototoxicity is high in our small series of long-term survivors of osteosarcoma. Baseline pre-chemotherapy testing, close monitoring during treatment and further follow-up are essential for this subset of patients receiving high doses of cisplatin.

The study was funded by Singapore Cancer Syndicate (POU-097)


G.U. Exner Eva Harasta Hp. Honegger A.R. von Hochstetter M. Paulussen

Rationale: Osteosarcoma predominantly affects adolescents and young adults. Reduced fertility in men is well documented following treatment for osteosarcoma and related to chemotoxicity.

We have however not found data about the health of children of patients formerly treated for osteosarcoma.

Among our few patients we have had one offspring with an infantile fibrosarcoma successfully treated with high dose chemotherapy and surgery. One mother has secondary gastric malignancy after successful pregnancy.

With this contribution we want to draw the attention to include data of children in the long-term implications of osteosarcoma and its treatment.

Materials and Methods: Patients: Of 75 patients with osteosarcoma 11 patients (5 women, 6 men) have 16 children‚ produced’ after completed oncologic treatment

All women became pregnant as planned. There are no female patients evidently infertile. One man among our patients shows azoospermia and is infertile. One man with oliogespermia has a healthy daughter after successful vitro fertilisation.

All patients have had treatment for osteosarcoma after puberty.

Offsprings: Pregnancy and delivery were uneventful for all children. The one girl mentioned above at birth showed a tumor of the Plexus brachialis which was a biopsy proven infantile fibrosarcoma. She received high dose chemotherapy. Resection of the tumor retaining the brachial at 9 months of age showed only scarce tumor residuals; she is disease free at 4 years of age. Her two siblings are healthy

Conclusion: We want to stress that in follow up studies events during pregnancy and health of offsprings should be included.


S. Ash I. Cohen Y. Goshen H. Toledano I. Yaniv

Increased intensity of therapy for osteosarcoma in the last 30 years has improved prognosis. 70–80% of patients with non metastatic osteosarcoma can now be cured, but late side effects occur. Fertility of survivors is becoming of greater importance.

We retrospectively studied all consecutive female long term survivors of localized osteogenic sarcoma of childhood and adolescence treated at the Schneider Children‘s Medical Center of Israel. Patients were treated with 3 different protocols including the use of Methotrexate, Adriamycin, Cisplatin, Bleomycin, Cytoxan, Vincristine, Actinomycin D, Melphalan and Ifosfamide.

Sixteen female survivors of non metastatic osteogenic sarcoma were treated from 1/1977 to 12/2001, with a minimum follow up of 6.3 years (max. 29 years) from the end of therapy. Median age at diagnosis was 11.7 (range 9.0–16.8) years. Twelve out of 16 (75%) are married and have between them 31 children, mean 2.7 (range 1–7) children. Of these 11 have children and one is currently pregnant with her first child. None of the females reported difficulties in conceiving their first child. The maximum interval from marriage to first delivery was 2.5 years. Two females had 3 spontaneous abortions between the 2nd–4th pregnancies. Four out of 9 female survivors who received > 360mg/m2 of adriamycin were treated with cardiomimetic drugs and/or ACE inhibitors during pregnancy. All four had 2–4 children/ female survivor. The children of survivors are healthy with no birth defects. Mean length of pregnancy was 38.6 weeks and mean birth weight was 2865 grams. No survivors had undergone invasive fertility preservation procedure and only one unmarried patient was using GnRH analogs.

Despite reports of transient disturbances in menstruation, all married females were fertile. Our results question the need for fertility preservation using GnRH analogs or invasive procedures such as ovary or egg preservation for non metastatic osteogenic sarcoma female patients.


C. Müller C.C. Winter V. Vieth J. Boos J. Hardes G. Gosheger D. Rosenbaum

Several studies report a diminished BMD as a consequence of childhood cancer treatment. The aim of this study was to investigate the effects of an exercise intervention on BMD during treatment, since limited mobility is characteristic for cancer therapy and is a major determinant for bone loss.

We analysed DXA scans (Lunar Prodigy, GE Healthcare) of 53 patients (range 8 to 21 years at time of diagnosis) perioperatively (n=49), six (n=38) and twelve months (n=18) after surgery. Scans were performed for the established sites of the lumbar spine and both femora, as well as experimentally for both calcanei. Areal BMD was corrected to obtain volumetric BMD using the model of Kröger.

For both groups, areal and calculated volumetric BMD values were similar at the lumbar spine at time of surgery, as were the differences between affected and not affected femur and calcaneus. The six and twelve months postoperative measurements revealed higher volumetric and areal BMD at the lumbar spine for the intervention group, although significant differences were only found for volumetric BMD values six months postoperatively.

Furthermore, a comparison of both groups showed that the loss in bone density of the affected lower extremity was less pronounced for the intervention group: differences between affected and not affected femur were 9% to 73% higher in the femur and 20% to 29% higher in the calcaneus for the control group.

Previous reports dealing with diminished BMD in pediatric cancer patients were confirmed in this study. However, differences found in BMD between both groups indicate that an exercise intervention during treatment, consisting primarily of strength and endurance training, may inhibit bone loss in pediatric sarcoma patients. Furthermore, the calcaneal site may be an alternative when the determination of femur BMD is not feasible.


C. Wibmer A. Leithner N. Zielonke M. Sperl R. Windhager

Increasing incidence rates of soft tissue sarcomas (STS) have been reported. In the present study the authors have analysed the incidence of STS in Austria in a population-based study for the period 1984–2004 in comparison with seven international studies.

Age-adjusted incidence rates, gender- and age-predilection and geographic differences were analysed, comprising data from the Austrian National Cancer Registry, including all cases of STS in Austria between 1984 and 2004.

A total of 5333 cases was registered, male to female ratio was 0.8. The most common histotypes were sarcoma NOS (36%), leiomyosarcoma (24%), liposarcoma (12%), malignant fibrous histiocytoma (MFH) (9%) and fibrosarcoma (5%). Age-adjusted incidence rate was 2.4 per 100,000 per year. Analysis of annual incidence rates and three-year-periods showed no increasing trend (annual increasing gradient = −0.0025).

This study analysed the most recent data from a European population in comparison with seven other studies. An increase of incidence of STS as postulated elsewhere could not be confirmed. The incidence rate of STS in Austria (2.4 per 100 000 per year) ranges in the lower half of international incidence rates (1.8–5.0 per 100 000 per year). Different inclusion criteria (Kaposi’s sarcoma and dermatofibrosarcoma) and classificationsin the various studies could be seen. These findings are more likely to cause the increase of incidence in some studies than true increase of STS due to new or accumulated risk factors.


C. Winter C. Mueller J. Hardes J. Boos G. Gosheger D. Rosenbaum

Pediatric patients with lower extremity sarcoma often experience long lasting restrictions concerning physical activity and walking due to the required off-loading of the limb and other consequences of surgeries. Activity promotion during treatment in addition to physiotherapy could improve patients’ activity levels and walking capabilities.

In the present study we investigated the ambulatory activity of 31 pediatric patients (13.7 ± 3.1 years, 1.63 ± 0.15 m, 51.9 ± 15 kg, 19.3 ± 3.7 kg/m2) with Osteosarcoma or Ewing sarcoma at the lower limb using the StepWatch™ Activity monitor (SAM; Orthocare Innovations, USA). Sixteen patients regularly underwent supervised exercise interventions during inpatient stays, 15 did not receive any additional intervention. Step activities were measured for seven consecutive days during home stays at five different points in time, to determine a possible transfer of activity to everyday life.

Patients without intervention assembled considerably less steps than those in the intervention group. Before surgery they reached 25.4% of the intervention group (total n=16), six weeks after surgery 40% (total n= 8), after three months 46% (total n=10), after six months 72% (total n=13) and after one year 90%. However differences only reached significance at the first measurement.

Data presented must be considered as preliminary. Not all patients could be measured at all appointments due to impaired walking ability. Nevertheless activity promoting interventions during inpatient stays seem to have a positive influence on patients’ daily walking activity. Though the differences between the groups are not significant they are considerable. Especially during treatment – as reflected by the first three measurements- patients could benefit from additional interventions exceeding typical therapy regimes. Interventions should be individualized to the patients’ capabilities. Conclusions concerning tumor location or surgical procedures are not yet possible. Future research should furthermore concentrate on the effects of activity promotion on other fields of well-being.


J.T. Hartmann

Soft tissue sarcomas (STS) include a spectrum of his-tologically and clinically different tumors. Patients are typically relatively young and the course of disease is characterized by early metastasis as well as limited response to chemotherapy. However, a few subtypes such as small round cell tumors (SRCTs) and rhabdomyosarcoma (except from pleomorphic), are considered chemotherapy-sensitive. In addition, reflecting successful translational research of recent years, gastrointestinal stromal tumor (GIST) and dermatofibrosarcoma protuberans have become model diseases for targeted oncological therapy. With a very limited number of active compounds at hand, treatment choices in metastatic STS with inkonsistent genomic alterations were easy to overview until only a few years ago. However, with novel therapeutic strategies such as the antiangiogenic approach and a multitude of novel compounds available both outside and within clinical studies, it may have become more difficult to keep track of currently available treatment options and their clinical safety and efficacy. Anthracyclines with or without ifosfamide are still considered standard of care in most STS-subtypes, especially in high-grade tumors. There is no evidence-based recommendation as to second-line treatment options. However, a number of established compounds, including dacarbazine/temozolomide, gemcitabine, taxanes, trofosfamide, DNA topoisomerase I inhibitors, DNA minor groove binders, and bendamustine, have shown activity. Recently, trabectedin, a DNA minor groove binder initially isolated from a sea sponge, has proven effective and received European approval for use in treatment-refractory STS. In addition, novel compounds such as bevacizumab, multityrosine kinase inhibitors, mTOR inhibitors, imatinib mesylate, and the thrombospondin agonist ABT 510 represent attractive partners for the above-mentioned cytostatic agents or may even be effective single agents in the clinically advanced setting. Novel combinations are being evaluated in clinical studies. In order to be successful, we may have to combine not only different compounds but also different targets beyond the proliferation machinery of sarcoma cells such as tumor angiogenesis, the tumor stromal compartment or tumor cell oncogene products.


E. Koscielniak

While STS as a group represent a significant portion of all solid tumors in childhood, individual histologic entities are rare due to their extreme heterogeneity. This represents the principal obstacle to clinical trials. A compromise between clinical vs. statistical precision has been necessary in the majority of clinical trials on STS resulting in contradictory conclusions. Clinical trials have to reduce uncertainty but trials, which overlook clinical heterogeneity can even contribute to it. An example is many clinical trials, which have been carried out in the recent decades to answer the question of the role of adjuvant chemotherapy in “Non-RMS-STS”. Majority of these trials have overlooked clinically relevant subgroups. The result is that we still do not have certainty whether and which adjuvant chemotherapy is beneficial.

In addition, most clinical trials of treatments for STS rely on the endpoints of survival or event-free survival, so results have taken years to accrue and even longer to report. However, in STS with well defined genetic abnormalities and strong preclinical rationale for activity of a molecular targeted therapy the demonstration of clinical activity in only a few cases might be sufficient. In dermatofibrosarcoma protuberans, a very rare entity, the demonstration of clinical activity of the molecular targeted therapy was very convincing and led to approval of the drug, although the number of cases was very low.

International collaboration is necessary to obtain a sufficient number of patients but participation of many different centers with different expertise for a given rare tumor may compromise the quality of patient’s care. It is also difficult for many pediatric departments to open and maintain large numbers of trials with low accrual rates.

In conclusion, new methods for clinical research in the field of STS especially surrogate outcome variables and novel technique for early assessment of response are urgently needed.


M. Stark T.M. Dantonello P. Winkler I. Leuschner T. Bölling G. Seitz E. Hallmen I. Veit-Friedrich S. Bielack M. Paulussen R. Ladenstein B. Kazanowska G. Ljungman T. Klingebiel E. Koscielniak

Tumour volume reduction (i.e. response), assessed following induction chemotherapy, has been identified as a prognostic factor for localized embryonal rhabdomyosarcoma (RME) in the CWS studies. In combination with other risk factors, it has been used to stratify secondary local and systemic treatment. It is however unclear whether the poor outcome of non-responders is due to insufficient local and/or systemic post-induction treatment.

We analyzed post-induction therapy of RME-patients < 21 years with unresected localized tumours (IRS-III) and poor response (NR, i.e. < 33% tumour volume reduction) treated 1980–2005 in five consecutive CWS-trials. The NR were reviewed and subclassified (Objective Response (OR; i.e.< 33%–0%) vs. Stable Disease/Progression (PD; i.e. no reduction)).

From 758 IRS-III RME-patients, 59 were NR (n=34 OR, n=25 PD). Induction for NR included dactinomycin, vincristine, alkylators ± anthracyclines in all patients. There were no significant differences in comparison of the control group and NR with regard to age, size, TN-classification, apart from site (p=0.04), and no differences regarding these parameters between OR and PD. Twenty-four NR received continued induction chemotherapy, n=32 other combinations, and n=3 no further chemotherapy following response assessment. Four patients were treated with additional high-dose chemotherapy. Fourty-two NR were irradiated with a median dose of 48Gy (control group: 45Gy). In 20 NR, the tumours were completely resected. As of 9/2008, with a median follow-up of 4.5 years (range: 0.9–12.1) for NR survivors, 34 NR are alive in CR. Reasons for the 25 deaths were: local/combined failure (n=21), systemic failure (n=1), and other reasons (n= 3). 5-yrs-OS was 71±4% for the control group, 78±15% for OR, but only 43±15% for PD (p< 0.01).

Response is an important surrogate marker of outcome, but per se associated with a poor prognosis only in tumours without any volume regression to induction chemotherapy. Ineffective local control drives mortality in these patients.


I. Sultan C. Rodriguez-Galindo R. Saab S. Yasir C. Meazza M. Casanova A. Ferrari

Synovial sarcoma (SS) is a typical soft tissue sarcoma subtype crosswise between the pediatric and the adult age groups. No published data describes a different biology of SS when arising in adults as opposed to children, but different therapeutic strategies have been developed for pediatric and adult oncology protocols dealing with SS (in particular concerning the use of systemic therapy) and different overall outcomes have been reported by pediatric and adult groups.

To better characterize the clinical features and outcomes of SS across the different age groups, we performed an analysis of all SS cases registered on the Surveillance, Epidemiology, and End Results (SEER) public-access database collected from various geographic areas in the United States, from 1983 to 2005.

We analysed 1268 cases, 213 children/adolescents (≤18 years) and 1,055 adults.

No major differences in stage distribution (localized, regional and distant stage) and clinical features were observed comparing the two age-groups, though a quite different pattern was recorded just for the small group of patients younger than 10 years (2.5% of cases, more extremity primaries, smaller tumors, mostly localized). The estimated 5-year cancer-specific survival was 83% for children/adolescents and 62% for adults (p< 0.001). Female sex, non-black race, tumors located in the extremities, localized tumors and tumors < 5 cm in size were associated with better survival. In multivariate analysis, adult patients had significantly higher mortality rates than children after adjusting for other variables.

In conclusion, our analysis showed that children/ adolescents and adults with SS have a similar clinical presentation but a dissimilar outcome, suggesting that factors other than unfavorable clinical features might be involved in the unsatisfactory outcome of adult SS patients. It remains to be ascertained whether this difference may be related to biological variables or to historically-different treatment approach adopted in pediatric versus adult patients.


O. Oberlin A. Rey T. La G. Bisogno E. Koscielniak M. Stevens W. Meyer M. Carli J. Anderson

Objective: To determine patient characteristics and outcomes for extremity rhabdomyosarcoma (RMS) utilizing an international cohort of prospectively treated patients.

Methods: Data were collected from 566 patients (1984 through 2003) treated on cooperative protocols : US IRS III, IV Pilot, IV studies – SIOP 84, 89, 95 studies – Italian ICG 79, 88, 96 studies – German CWS81, 86, 91, 96 studies.

Results: 29 % of the patients were < 3 year old, 36 % were 3 to 10 year old and 35 % > 10 year old. 350 (63%) patients had alveolar RMS and 116 (22%) had regional nodes.

The overall survival and EFS were 65% and 51% at 5 years respectively and 59% and 48% at 10 years respectively.

By univariate analysis, EFS was influenced by age below 3 years but not by age over 10 years (EFS were 61%, 49% and 46% for patients below 3 years, from 3 to 10 and 10 years or more respectively). It was also influenced by tumor invasiveness, tumor size, lymph node involvement, histology, completeness of surgery at diagnosis and cooperative groups. In multivariate analysis of EFS, size, lymph nodes, quality of surgery, cooperative groups had independent impact. Age and histology had no more impact.

OS (univariate analysis) was influenced by age below 3 years but not by age over 10 years (OS were 77%, 61% and 58% for patients below 3 years, from 3 to 10 and 10 years or more respectively). In multivariate analysis, age, lymph nodes, tumour invasiveness, quality of surgery at diagnosis had independent impact. Histology, tumour size and cooperative groups had no more impact.

Conclusion: This analysis shows that significant cut-point for age is 3 years, that histology per se has no impact on OS and EFS. It also underscores the impact of initial surgery on outcome.


S. Stegmaier E. Aakcha-Rudel P. Muench K. Simon-Klingenstein C. Poremba K.L. Schaefer I. Leuschner B. Kazanowska A.N. Békássy C. Int-Veen E. Hallmen I. Veit-Friedrich T.M. Dantonello S.S. Bielack J. Treuner T. Klingebiel E. Koscielniak

Alveolar Rhabdomyosarcoma (RMA) are characterised by chromosomal translocations fusing the PAX3 or PAX7 gene with FKHR in ~85%. Previous studies have suggested that PAX3/7-FKHR fusion types are related to prognosis. In order to prove these findings we performed a retrospective analysis of the PAX-FKHR fusion status and its relation to outcome in patients treated in the CWS trials.

Between 1986 and 2004, out of 446 RMA patients treated in four consecutive CWS trials (CWS-86, -91, -96 or -2002-P), tumor samples from 121 patients with adequate quality for analysis of PAX-FKHR fusion status by RT-nested PCR were available. Survival analysis depending on clinical risk factors and fusion status was performed using the Kaplan-Meier Method, the log rank test and the Cox regression model.

There were no major differences in distribution of known risk factors in the analysed cohort of 121 patients compared to all patients enrolled in the CWS trials. PAX-FKHR fusions were detected in 83%: 72 PAX3-, 29 PAX7-FKHR fusions. Patients with PAX3-FKHR positive tumors more often showed a pattern of adverse clinical risk factors (age > 10 years, primary metastases, lymph node involvement) than the PAX7-FKHR positive group. The 5-year event free survival rate of patients with initially metastatic tumors positive for either of the two fusion transcripts was significantly lower compared with the fusion transcript negative cohort and the non-analysed RMA patients. There was no significant outcome difference between patients with PAX3-FKHR and PAX7-FKHR positive tumors in uni- and multivariate analysis.

In the present analysis, which is to our knowledge the largest reported so far, PAX-FKHR fusion type was no significant predictor for prognosis, thus not supporting results of previous studies.


P. Darcy W. Maruwge B. Brodin

Mutations of the p53 gene are uncommon in synovial sarcoma, a high-grade tumor genetically characterized by the chromosomal translocation t:(X;18), that results in the fusion of SS18 with SSX gene.

We recently reported that SS18-SSX1 negatively regulates the stability of p53 by promoting its ubiquitination and degradation in a manner dependent on the ubiquitin ligase activity of HDM2. The negative effect of SS18-SSX1 expression on p53 was mediated by its ability to promote HDM2 stabilization through inhibition of HDM2 autoubiquitination. The final outcome translates into a deficient transactivation of p53-regulated genes: HDM2, PUMA, and NOXA that are important to preserve genomic integrity in response to cellular stress.

Our data uncovers a novel mechanism whereby, in synovial sarcoma cells with wild

type p53, the SS18-SSX oncoprotein can negatively regulate p53 tumor-suppressive function by increasing the stability of its negative regulator HDM2.

We further hypothesise that chemical compounds that target the p53-HDM2 regulatory axis may rescue p53 function in synovial sarcoma. With this in mind we investigated the potential of the HDM2 antagonists, nutlin-3 and of the recently discovered tenovin 1, to rescue p53 activity in synovial sarcoma cells lines. Nutlin-3 effectively stabilized p53 half-life and trans-activating function, resulting in cell growth arrest and apoptosis.

We further observed that chemotherapeutic agents like doxorubicin also stabilized p53 in response to DNA damage but did not restore p53 transcriptional activity due to rapid complexing of p53 to HDM2. On the contrary, nutlin-,3 stabilized p53 and inhibited p53-HDM2 interaction, thereby rescuing p53 tumor suppression function. Our results suggest that the inhibition of the p53-HDM2 interaction by small molecules is a highly potential therapeutic strategy for soft tissue sarcomas with wild type p53.


A. Parafioriti S. Del Bianco E. Armiraglio P.A. Daolio S. Mapelli

Synovial sarcomas are mesenchimal tumours with unde-fined histogenesis which represent 5–10% of soft tissues tumours; they are divided into different subtypes according to morphology and epithelial differentiation. From a molecular point of view, synovial sarcoma is characterized by t(X;18)(p11;q11) translocation which joins SYT gene with a member of SSX gene family. We developed an efficient method to detect the two main fusion transcripts SYT-SSX1 and SYT-SSX2 based on RT-PCR or Real-Time PCR applied to archival paraffine-embedded samples.

This study includes 49 patients surgically treated for synovial sarcoma and analyzed with routine immuno-histochemical analysis. We used alternatively nested-PCR or Real-Time PCR, with SYBR green method, to detect SYT-SSX transcripts: these techniques allowed us to discriminate between the two transcripts.

In 42 subjects out of 49 we could find a specific fusion transcript and, in particular, 31 patients were carriers of SYT-SSX1 translocation. Interestingly we could find 6 patients who were carriers of both SYT-SSX1 and SYT-SSX2 transcripts. We selected nine samples for Real-Time PCR analysis and we could quantify the reciprocal ratio between the two fusion transcripts when they were both present in the same sample.

The use of molecular techniques such as RT-PCR represents a sensitive and reliable tool as a support to histopathologic diagnosis of synovial sarcoma. Moreover, Real-Time PCR enormously enhances sensibility and enables to determine single transcript quantity when both SYT-SSX1 and SYT-SSX2 are present in the same sample. This method can also be used to reclassify those cases whose diagnosis is still undefined after routine analysis.


A. Williams R.J. Grimer G. Bartle V.P. Sumathi C.M. Mangham J.M. Meis L-G. Kindblom

Background: ASPS is a rare, high grade sarcoma primarily affecting children and young adults. Its origin remains enigmatic and there has until recently been no diagnostic markers. Diagnostic problems particularly occur when presenting as metastasis before detection of the primary tumour and when there is morphologic overlap with other malignancies. Recently, identification ASPS/TFE3 fusion transcripts and immuno-detection of TFE3 have been reported as useful diagnostic tools.

Design: 17 ASPS were analysed in terms of clinicopatho-logic characteristics, treatment and follow up. Archival formalin-fixed and paraffin embedded tissues were used for TFE3 immuno-histochemistry and RNA extraction followed by RT-PCR analysis and sequencing. Novel primers to detect ASPS/TFE3 fusion transcripts, type 1 and 2, were designed.

Results: The patients, 9 females/8 males, ranged in age from 3 to 46 years (median 23 years); 16 involved the extremities (9 lower, 7 upper) and one the pelvis. All but one patient had primary, curative surgery; chemotherapy and radiotherapy was given for metastatic disease. Five had lung metastases at diagnosis and 3 developed lung and brain metastases later. Four patients died of disease (after 1–5 years), 4 are alive with metastases and 9 are alive and well (after 6 mos.-10 years). 15/15 ASPS showed ASPL/TFE3 fusion transcripts (8 type 1, 7 type 2) and TFE3 immuno-positivity. Of 26 control tumours, several of which with overlapping morphologic features, none had fusion transcripts, 4 showed immuno-positivity (all granular cell tumours).

Conclusions: Immuno-detection of TFE3 and RT-PCR based identification of ASPL/TFE3 fusion transcripts in formalin-fixed/paraffin embedded tissues are powerful tools in the diagnosis of ASPS.


B. Timmermann C. Ares A. Staab T. Bölling J. Salk M. Frei F. Niggli G. Goitein E. Hug

Proton beam radiation (PT) is getting an increasing role in the treatment strategy of complex tumour cases and especially in children. AT PSI, over 100 children were treated so far.

In this analysis we present the evaluation of 62 children treated until the end of 2007 for sarcomatous tumours. Twenty-nine girls and 33 boys were included. Median age at time of diagnosis was 8.1 yrs. (range, 0.1–19.0). The histopathologies were embryonal RMS (n = 24), Chordoma (n = 10), Ewing sarcoma (n = 6), Chondrosarcoma (n = 5), unclassified/undifferentiated RMS (n = 5), Osteosarcoma (n = 4) and miscellaneous. All, but 2 patients had localized disease at time of diagnosis. Tumour site was head and neck in 43 patients, and spine or pelvis in 19 patients. In 50 out of the 62 patients, PT was performed after biopsy or incomplete resection. Forty-four patients had received chemotherapy before or during PT. Median dose of irradiation was 54 Gy (range, 45 – 74 Gy) with 1.8–2.0 Gy fraction dose 4 – 5 times weekly.

Median FU time was 20 months (1.4 – 101). 54 children were still alive at the time of analysis. Twelve patients failed, of them 9 locally and 3 patients at distant site. Acute toxicity was exceeding grade 2 (RTOG/ EORTC) mainly for bone marrow in children with parallel chemotherapy (n = 23). In 6 children skin/mucosal reaction was exceeding grade 2. Late effects were not exceeding grade 2 in the majority of children. One serious adverse event was observed in a very young girl with a parameningeal sarcoma experiencing a lethal ischemia in the pontine area after surgery, chemotherapy and PT.

In the vast majority of patients proton therapy was well tolerated. Local control and survival rates are promising. Longer follow-up time and a greater cohort will help to provide more reliable data.


F. Gouin A. Moreau E. Cassagnau E. Bompas D. Waast F. Lintz

Planning resection margins for soft tissue sarcomas is a compromise between functional sacrifice and therapeutic safety. In practice, the histological analysis of the resection margins often shows that the preoperative objective has not been achieved. We studied the prevalence and factors of risk of this surgical outcome.

This was a prospective monocentric study of 133 patients. The resection objectives, pathological results and operative reports were examined. Margins were classified according to the UICC (R0, R1, R2). Data were included in a grid which also included patient related and tumour related preoperative information. Inadequate resection was noted as planned R0 with R1 or R2 outcome. Statistical analysis was performed with Statview 5.0.

The prevalence of inadequate resection was 25.2%. Among the factors analysed, the aspect of tumor limits (badely or well defined) was significantly related to poor surgical results (odds ration 2.85 [1.47–5.52], p < 0.005). No other significant risk factor could be identified. Margins greater than two mm were associated with adequate surgery in every case.

No preoperative risk factor predictive of inadequate resection margins was clearly identified in this study. Postoperatively, the microscopic aspect of the proliferation limits at the final pathology examination is for us significantly associated with inadequate resection. However the current classification for resection margins lacks precision, especially regarding R0 and R1 when margins are small, in defining the risk of inadequate resection. This appears to be the source of the difficulties encountered in interpreting pathology samples and therefore in choosing the right treatment. Further follow-up is needed to clarify such questions.

We conclude that where resection margins are thin (less than two mm), the definition of R0 or R1 resections should be clarified to optimize patient care. To achieve this, potential risk factors for inadequate resection such as tumor limits should be taken into account and further studied.


J. Godzinski B. Kazanowska G. Sobol A. Raciborska W. Wozniak B. Dembowska D. Perek M. Rapala P. Miskiewicz K. Bronowicki

Synovial sarcoma (SS) of childhood is considered chemoresponsive, what frequently leads to conservative surgical approach.

Aim of the report is to assess whether that approach is sufficient and what are other clinical factors influencing the outcome.

Patients: 23 children (aged 3 months – 17 years) treated in 5 cooperating centres for nonmetastatic SS located in the limbs(Fu> 36 months). Treatment: primary or secondary resections, chemotherapy and radiotherapy (in case of resection R1 or R2 or relapse). Locations of tumours: thigh/6, shank/1, popliteal fossa/4, cubital fossa/3, axilla/2, forearm/2, foot/3, arm/1, hand/1. Primary R0 achieved in 3, R1/5, R2/3. Twelve after initial biopsy and 3 after primary R2 were submitted to chemotherapy and secondary surgery. 12/15 those resections were R0, 3/15 R1. Two of them underwent mutilating resections.

Results: 11 pts are in CR. 12 relapsed (7 local, 5 metastatic). Initial locations of the relapsing tumours were around joints/4, foot/hand 4, thigh 3, arm 1. Seven of them died despite aggressive re-treatment, 2 are alive with disease, 3 are in second CR. Quality of resections (primary or secondary) in 7 locally relapsing pts were R0 in 3, R1 in 3 and biopsy only /1 (CR after CHT alone, refused local treatment). Of 2 submitted to mutilating resections, 1 relapsed in the lungs (2nd CR after re-treatment and metastasectomy).

Summary:

R0 doesn’t prevent from local relapse (3 of 7 pts relapsed after R0 vs 4/7 with R1).

Mutilating resections (amputations) were unfrequent (2) and were not followed by local relapses. One metastatic relapse occurred and was finally cured.

Locations at risk seemed joints and distal parts of limbs (8/12 of the relapsing pts).

Relapsed implied weak chance for long-term second CR (3/12).


M. Greulich D. Haug F. Schober

Local control cannot be achieved in many cases of soft tissue sarcoma by surgery alone. Additional irradiation is often necessary. This reveals the question of the optimal sequence of resection, reconstruction and irradiation.

Material: We present

A review of the literature concerning preop and postop irradiation in soft tissue sarcoma.

The criteria of decision making in 15 cases of our own patients concerning the question of preop and postop irratdiation.

Results:

Review of the literature: There ist a certain benefit in additional irradiation concerning local control, but there is no evidence in favour of preop or postop irradiation concerning overall survival.

Clinical cases:

Preop irradiation is preferred in all cases of microvascular bone repair in order not to interfere with bony healing and hypertrophy of the transplants.

Pathological fractures after irradiation are very difficult to treat.

In children irradiation has to respect the epiphyseal areas.

Microvascular tissue transfer after irradiation may fill up big tissue defects after wide resection, may improve wound healing and prevent lymph edema


H. Cornille S. Alkhallaf N. Delepine B. Markowska G. Delepine

Congenital fibrosarcoma (CFS) is a rare tumor most often affecting extremities of babies. Considering age, surgery of primary is preferred. Nevertheless amputation rate remains high. Preoperative chemotherapy (CT) role must be emphasised. We present 3 cases receiving preoperative CT.

Patients and methods in 1985, we treated a 3 months old girl for CFS of the thigh. To avoid amputation, preoperative CT (3 Ifosfamide- Vincristine- Actinomycine D) was performed leading to complete radiological and histological response. She benefited of conservative surgery She is in first complete remission 23 years later.

In September 1999, a 3 ½ y old boy with recurrent l buttock CFS operated elsewhere twice (6 months old, 2 years old), received preoperative chemotherapy with good clinical and radiological response. “En-bloc” extra tumoral resection was performed. Histology showed viable tumoral cells. We completed treatment by chemotherapy. In 01/ 2003 bilateral pulmonary metastases occurred leading to surgery and chemotherapy. In 09/ 2003 a new local recurrence appeared treated by surgery and postoperative chemotherapy. From this time, he received Alpha interferon. He is in complete remission for 6 years.

In 12/2005, a 14 y old girl, with local recurrence of CFS, treated elsewhere at the age of 5 months by partial surgery and chemotherapy (remained in remission for 13 years)was admitted. Since this time, she recurred locally despite resections and multiple lines of chemotherapy, but without metastasising. She was amputated in 2008.

Conclusion: preoperative chemotherapy is feasible despite low age of the patients, can allow conservative surgery and avoid late metastases.


G. Seitz J.F. Schäfer V. Ellerkamp K. Dietz A. Bosk I. Müller S.W. Warmann J. Fuchs

Radical surgical resection of metastases is an important prognostic factor for survival of patients suffering from solid pediatric tumors. The aim of this study is to evaluate the efficacy of median sternotomy as treatment option for the resection of multiple bilateral lung metastases in children with different tumor entities. Furthermore, the sensitivity of preoperative imaging (CT) was assessed by intraoperative findings.

Between 2002 and 2007, thirteen children (4x sarcoma, 4x nephroblastoma, 5x hepatoblastoma) underwent median sternotomy for resection of bilateral lung metastases after R0 – resection of the primary tumor. In 6/13 cases, the sternotomy was combined with the primary tumor resection.

Median patients at the first operation age was 5 years (range: 11 months – 17 years). The median total number of resected metastases per operation was 9 and ranged from 0 to 65. In 13/16 operations, the intraoperative number of metastases did not agree with the preoperative radiological work-up. Median hospital stay was 14 days (range from 9 to 36 days). 10/13 children are alive after a median follow–up of 13 months (range from 6 to 66 months).

Median sternotomy is an adequate treatment modality for the resection of bilateral pulmonary metastases as a one stage procedure. The combination of primary tumor resection with sternotomy should be considered as treatment option. Complete resection of metastases of solid pediatric tumors should be aimed for in order to increase the survival of these patients.


M. Dragomir R. Anghel E. Gruber C. Comsa

Beckground: Head and neck region is a rare site location for sarcomas and there are difficulties of surgery management.With the exception of those arising in relatively superficial locations, are rarely amenable to wide local excision. Incisional biopsy for diagnostic purposes is usually all that is feasible. Multimodal treatment is mandatory to achieve local control.

The present study examines multimodal treatment outcome in children and adolescents with head and neck soft tissue sarcomas (H& NS).

Patients and Methods. Patients with H& NS who underwent chemotherapy +/− radiotherapy, after surgery, in Institute of Oncology Bucharest between 1990– 2007 were identified. Clinical charts and pathology reports were examinated.

The study included 42 pts.(29 male and 13 female); median age was 14 years years (range 3 – 21)

Sites of primary tumor: parameningeal: 18 pts; non-parameningeal 16 pts and orbit: 8pts. Histologic types: rhabdomyosarcomas and undifferentiated sarcomas represent 52%. Staging (TNM pretreatment staging classification for IRS-IV): St. I+II-36% ; St. III- 34%; St.IV-30%

All the pts were treated multidisciplinary: Surgery + Chemotherapy(PCT) +/− Radiotherapy(RT). Type of surgery performed: partial excision:54%; complete excision: 4 pts (9%); incisional biopsy: 37%. Type of RT: Exclusive RT in inoperable tumors(4 pts) ; external RT- postoperative(59%) curietherapy: 1 pt; gammaknife: 1pt. Neoadjuvant PCT were applied for 16% of pts and adjuvant PCT for 85,7% of pts.. Chemotherapy protocols used after 1992 was: IVA, IVE, VAIA, CEVAIE, and before 1992: CYVADIC, CYVADACT. All cases were followed minimum 2 years after the end of the treatment.

Results: Overall survival estimated by Kaplan Meier curve: 66%/ 1 year, 43%/ 5 years. OS according to the stages of disease ; stage I-II: 93% at 1 year,73% ar 5 years; stage III and IV: 47% at 1 year, 23% at 5 years.

EFS in sarcomas treated with S+PCT+RT is 41%, versus 16.5% for sarcomas treated with S+CT.

Observations: The diagnosis in advanced stages was due to the confusion with nononcological diseases.

Conclusions: 1. EFS was highest in sarcomas treated S+CT+RT face to sarcomas trated S+CT. 2 EFS at 2–3 yrs. in children’s soft tissues sarcoma could be considered as cure.


P.A. Daolio M. Innocenti S. Bastoni S. Mapelli

Congenital infantile fibrosarcomas (CIFS) is a rare tumor of childhood that can be diagnosed from birth to 15 years. It has a ratio of 3.74/100 000 children and is well defined nosological entity with a well-defined pathogenetic patterns: translocation (12, 15) (p13, q25) with fusion of the gene ETV6-NTRK3.

The differential diagnosis of upper CIFS in infants must be made with lymphatic malformations, and when associated with the Kasabach-Merritt phenomenon’s (disseminated intravascular coagulopathy), haemangiomas, emangioendotelioma kaposiforme. In 26% of cases is congenital, while in 63% is diagnosed in the first 5 years. Unlike fibrosarcomas of the adult is characterized by a low rate of metastasis and a high survival rate (90% at 5 years). 74% of cases is observed in the limbs (upper> lower, distal> proximal).

The treatment of choice should to be, where possible, limb salvage and the recurrences are variable between 17% and 43%. The purpose of this paper is to present a case of CIFS, the clinical features, the oncological treatment, the reconstructive solutions and functional results obtained after reconstruction. Case report.

The child (Z.A. female), was diagnosed with a neoplasia of soft tissues of the right forearm before birth.

At birth the child underwent a needle biopsy with a diagnosis of CIFS.

The patient received four cycles of chemotherapy with reduction tumor mass of more than 50% of volume.

At month four she underwent an exeresi with wide margings and sacrifice of the radial nerve.

The reconstruction required a free flap of re-innervated latissimus dorsi muscle. After 30 months from the surgical procedure the child is disease free and has recovered extesion of the muscles of the hand and fingers.


A.V. Shvarova M.S. Kubirov R.S. Ravshanova R.M. Kajumov N.M. Ivanova

Synovial sarcoma is the most common NRSTS, that typically affects the extremities of adolescents. To improve the results of the treatment of synovial sarcoma for children and adolescents is the target of this study. 19 children and adolescents at the mean age of 10,84±3,28 years (9 males, 10 females) with synovial sarcoma were treated between 1999 and 2008 years at the Research Institution of Pediatric Oncology in the Russian Cancer Center. Histologically, 5 patients had the biphasic,12 had the monophasic, and 2 of them had the poorly differentiated pattern. The most often affected area was the area of the lower extremity – 10 cases, the area of the upper extremity was affected in 3 cases, and the trunk – 6 cases. According to the staging systems adopted, the size > 5cm (TB) was reported in 12 cases. Five patients (non-staging) had relapse of disease. Four patients had nodal involvement, and 4 had distant metastases (mostly at lungs).

The general scheme of the treatment included: 8 courses of chemotherapy (used ifosfamide or cyclophosphamide, ethoposide, carboplatine); the harvesting and preservation of the stem cells after the stimulation of the haemophoesis by G-CSF, the stage of the local control of the tumor consisting of the surgical ablation of the primary lesion (in 1 case it was not available) and the radiotherapy of the initial tumor and metastasis left after the induction.

The partial effect was registered by most of the patients – 80%. We observed 1 case of progression of the disease during inductive CT. The toxicity of intensive chemotherapy was reduced by support of sub transplantation doses of peripheral blood stem cells – 0,9-1,5±0,1·106 per kg. In our research we have analyzed the 5-year overall and disease free survival. Thus, 5-year disease-free survival was 66,1±11,3 %, overall 5-year survival −75,6±10,6%.


D.B. Hestanov A.V. Igoshin A.V. Shvarova N.M. Ivanova M.D. Aliev

The purpose of the our study was to analyze prognostic factors characterizing biological behaviour of a tumour and specific features of the patient and to develop rational strategy of the combined treatment of malignant fibrous histiocytoma (MFH) in children.

Between 1982 and 2008 fifty patients with MFH were observed and treated in our center. 24 (48%) were male and 26 (52%) were female. In all cases the diagnosis was confirmed by histological examination. We use polychemotherapy consist of alternating courses of CDDP, adriamicin, ifosfamide and etoposide and high-dose methotrexate (8–12 g/m2). Intensive polychemo-therapy allow us to expand indications for limb salvage treatment. Using growing (conventional and non-invasive types) endoprostesis improved the quality of life. 2-years RFS was 80,9±8,5% and 5-years RFS was 70,4±10,1% (Kaplan-Meier curves, p=0.03). The most significant prognostic factors were grade of histological response and type of polychemotherapy (conventional or intensive).


Ewa Bien Bernarda Kazanowska Jan Godzinski Tobias Dantonello Elżbieta Adamkiewicz-Drozynska Anna Balcerska Wojciech Madziara Aleksandra Rybczynska Joanna Nurzynska-Flak Elzbieta Solarz Andrzej Kurylak Beata Zalewska-Szewczyk Ewa Koscielniak

Objective: providing the rarity of malignant and intermediate vascular tumours (MVTs, IVTs) in children little is known about their clinical course, optimal treatment and variables predicting survival.

Material and methods: 32 children with MIVTs (14 angiosarcomas-AS, 5 epithelioid haemangioendotheliomas-EHE and 13 IVTs), registered in Polish and German Paediatric Soft Tissue Sarcomas (STS) Study Groups, treated with CWS-81, −86, −91 and −96 protocols.

Results: AS presented with advanced disease (84%), deep-seated T2 invasive tumours (71%), > 5cm in diameter (64%). Primary excision (PE) was incomplete in all and response to CHT/RTX disappointing. Nine/14 children entered CR; however all relapsed and, except one, died of disease. EHE and IVTs presented mainly in local stages (66,7%) and tumours > 5cm (72%). Complete PE was feasible in 30% and response to CHT/IFN poor in half. 16 patients entered CR, but six relapsed and, except one, died of disease.

In multivariate analysis male gender, AS histology, tumour size > 5cm, T2 invasiveness and lack of CR after Ist line therapy were independent predictors of poorer 5-year-OS, while AS histology and T2 invasiveness – of inferior 5-year-EFS. Radicality of PE was an independent prognostic factor for survival in univariate but not multivariate analysis.

Conclusions:

Current WHO classification has placed EHE in MVTs, however it may behave similarly rather to IVTs than AS.

Male gender, AS histology, tumour size > 5cm, T2 invasiveness and lack of remission after Ist line therapy were independent predictors of inferior 5-year-OS while AS histology and T2 invasiveness – of inferior 5-year-EFS.

In contrast to most studies, radicality of PE was not an independent prognostic factor for survival.

High rate of patients not responding to classic CHT and developing metastatic recurrences suggests an urgent need for modification of systemic therapy.

Problem of efficient therapy of childhood AS is the most appalling.


Y.V. Vishnevskaya D.V. Martynkov T.K. Charatishvili B.Y. Bohyan M.D. Aliev

Analysis of correlation of proliferation index Ki67 with grade and recurrence type of soft tissue sarcomas.

We reviewed 34 patients treated in RCRC RAMS. 53% patients were female, 47% – male. Adult patients – 97%, children – 3%. Soft tissue tumors localized on lower extremities in 47% cases (hip, shank), on upper extremities in 20% cases (shoulder, forearm, hand), on trunk in 24% cases, on head and neck in 9% patients. Histological subtypes were monophase synovial sarcoma – 32%, malignant fibrous histiocytoma – 23%, liposarcoma – 18%, malignant shwannoma – 6%, and other types in isolated instances. Synovial sarcoma more often observed in young and middle age women, malignant fibrous histiocytoma – in old men, liposarcoma – equally often in middle and old men and women. We observed soft tissue sarcoma grade 2 (FNCLCC) more frequently. Local recurrence development in 35% cases, number of recurrences was from 1 to 6. Distant metastases were in 8 patients (in lungs, lymph nodes, bones). We used monoclonal antibody Ki67 (clone MIB-1). Proliferation index Ki67 evaluated in the following way: low level – < 25% of tumor cells, middle level – 25–50%, and high level – > 50% of tumor cells.

Proliferation activity Ki67 increase in cases with high grade soft tissue sarcoma (in grade 1 tumors – low and middle proliferation activity, in grade 2 tumors – middle and high proliferation activity, in grade 3 tumors – only high proliferation activity).

Proliferation activity Ki67 increase in recurrent tumors (2–3 times more in comparison with primary tumors).

In cases with low level of proliferation index Ki67 were observed more number of local recurrences (> 3), and long interval to distant metastases. If level of Ki67 was high, time interval to local recurrence was short, number of local recurrences < 3, lethal outcome occurred often.


T.M. Dantonello I. Leuschner A. Schuck M. Greulich E. Hallmen I. Veit-Friedrich B. Kazanowska J. Godzinski S. Bielack T. Klingebiel E. Koscielniak

Liposarcoma (LPS) is among the most common soft tissue sarcoma (STS) in adults, accounting for > 10% of all STS. In children and adolescents, however, LPS are a rarity. Limited data about best treatment of pediatric LPS are derived from the scarce single-centre reports encompassing no more than a dozen patients.

Between 10/1980-6/2008, 18 of > 3,500 patients < 19 years with sufficient clinical data registered with CWS in Germany and Poland had a first diagnosis of LPS confirmed by reference pathologic review.

Median age was 14 years, median follow-up for survivors as of 2/2009 seven years. Sixteen patients had localized, two metastatic LPS at diagnosis. Lymphnodes were affected in a single case. The most frequent primary site were the limbs (n=11), the remaining seven were trunk tumours (abdomen n=4, thorax n=3). 10/18 primary tumours were > 5cm. Thirteen LPS were completely resected at best surgery, and microscopically residual disease remained in two more tumours. Six individuals received radiation with a median dose of 45Gy, including one of the two R1-resected patients. Nine patients received multiagent chemotherapy (only two of them since 1996 onwards). Response to induction treatment could be assessed in three of these nine individuals, but tumour volume regression occured in a single case only. Four patients died of disease, among them two of the three patients who did not achieve a CR with primary treatment. Two relapses (one combined, one metastatic), both involving the lungs, occurred one years after diagnosis and these patients were not salvaged. Actuarial 5-year EFS and OS survival rates were 69±23 and 81±20%, respectively.

LPS account for < 0.1% of childhood STS. The golden standard of treatment and key to cure is complete surgical excision. The role of radiation and/or chemotherapy remains unclear, but both modalities do not appear to be indicated in completely resected, localized tumours.


H. Ozger M. Sungur B. Alpan A. Kochai B. Toker L. Eralp

The nonrhabdomyosarcoma soft tissue sarcomas constitute a heterogenous group of rare mesenchymal tumors that account for less than %5 of pediatric cancers. Their biology and optimal treatment is not well understood. This study retrospectively analyses a small subset of surgically treated patients.

Fifteen patients with a mean age of 11.4 years (4 months – 16 years) were followed-up for a mean of 48 (2–124) months. The histologic diagnosis was synovial sarcoma in 5 patients; soft tissue Ewing Sarcoma in 3; fusiform cell sarcoma in 3; malignant peripheral nerve sheath tumor in 2; fibromyxoid sarcoma in 1 and myxoid liposarcoma in 1. The tumor was located in the upper extremity in 6 patients; thigh in 4; inguinal region in 2, foot in 2 and gluteal region in 1. Eight patients received preoperative chemotherapy and 5 received preoperative radiotherapy. Two patients had pulmonary metastasis at the time of admission. Thirteen patients were operated by limb salvage procedures and 2 underwent amputation.

Tumor resection was radical in 2 patients, wide in 12 and marginal in 1. Five patients received adjuvant chemotherapy and 5 received adjuvant radiotherapy. There were 5 local recurrences after 23.8 (14–40) months; three patients underwent wide resection for recurrence and two received chemotherapy and radiotherapy. Three patients had systemic metastases after a mean of 32.3 (27–40) months. There were no major complications but local wound problems were encountered. Three patients died of disease after a mean of 65.3 months (32–124 months). Two patients had metastatic disease and 10 had no evidence of disease in the last follow-up visit.

Pediatric soft tissue sarcomas can be treated following the principles of adult soft tissue sarcomas, except for wide utilization of radiotherapy in neoadjuvant and adjuvant setting. Treatment results are similar to adult patients.


A. Neumann E. Korsching A.M. Cleton-Jansen R. Duim H. Bürger K. Agelopoulos

Osteosarcoma (OS) is the most common primary malignancy of bone, with up to 80% of patients suffering from metastatic or micrometastatic disease at the time of diagnosis. For the metastatic potential of tumours invasiveness plays an important role. This study intends to determine new candidate genes for cell invasiveness.

Eight OS cell lines (MNNG, HOS, MG63, SJSA1, OST, ZK58, U2OS, SAOS) were analysed using a modified Boyden Chamber Assay to separate invasive and non-invasive cells. Total RNA isolation and Illumina hybridisation Arrays (V3 bead arrays) were performed for both fractions.

Out of the eight cell lines, five (MNNG, HOS, MG63, SJSA1, OST) displayed an invasive fraction between 1.76 and 0.02%, which proved sufficient for subsequent RNA analysis. Pair wise comparison yielded 161 differently expressed genes between invasive and non-invasive cells. These are involved in important pathways such as cell motility, cell communication or signal transduction.

The generated new candidate genes might play an important role in metastasis of OS. Their functional characterization has been started combining knockdown experiments (RNAi) with the invasion assay. Validation will be done by RT-PCR and immunohisto-chemistry on a larger sample using OS-TMAs. Determined genes and pathways will be correlated with clinical parameters like metastasis, survival and chemotherapy sensitivity in order to improve understanding of the biology of OS.


H. Ahrens R. Dieckmann A. Streitbürger M. Balke G. Gosheger A. Günsel J. Hardes

Infections are the most uneventfull complications after tumor resection and implantation of a maegaendopros-thesis.Silver-coating of megaendoprosthesis has become a regular procedure in our department since last year in tumor cases. Especially in revision cases with high risk of infection they play a major role in preventing adhesion of bacteria. The successful reduction in infection rates show the effectiveness of the coating but still leave the question “how much coating do we need?” and “how much coating can be tolerated.

Latest research concentrated on the coating of the stems, since they can still be the source of the infection if everything else is coated by silver already.

Summarised so far, our experience in a rabbit model, a phase I Trial in humans and prelimnary results in Phase II Trials in humans showed no toxic side effects.

Driven so far it seems to be sensible to extent the silver coating. So far, the coating is limited to all areas without joint movement or bone contact. An Animal trial was performed anylising the osteointegrative properties of an silver-coated stem versus an regular Titanium stem in 17 dogs. After 12 months of regular X-Ray Analysis a Pull-out test and a concentration analysis has been done.

Results showed high significantly (p< 0.001) an osteointegration in 8 out of 8 titanium stems with an average pull-out force of 3764 Newton (Range 1755– 5967 Newton). Silver-coated stems showed no signs of Osteointegration in all 9 out of 9 femurs. The average pull-out force was 21 Newton (Range 0– 186 Newton). A cemented control could resist a pull out force of 350 Newton. Analysis of the silver concentration directly in the first millimeter of the bone-implant interface and the second millimeter showed highly elevated silver levels.

The silver concentration in the bone-implant interface at Titanium stems ranged from 0.3 to 3502 parts per Billion (ng/g) compared to silver-coated stems ranging from 303 to 2.418.800 ppb parts per Billion (ng/g).

Discussion: Sharing the histologic picture and reactions of the osteoblasts to the silver-coating there are several possible reasons for failed osteointegration. We want o discuss wether these has to be considered as a toxic response or just an adverse reaction.

In summary, surgeons have to decide in the future how much silver they need in each individual case concerning intramedullary infection prophylaxis. The balance between loosening or infection should be based on long term expectations, taking into account that even after successful resection of a tumor an ongoning infection can lead to loosening of a limb or even life. Apart from intramedullary use, we recommend silver as a safe adjuvant therapy in all suited patients undergoing endoprosthetic reconstruction after tumor resection.


H. Clar P. Krippl W. Renner U. Langsenlehner A. Leithner G. Gruber G. Hofmann B. Yazdani-Biuki T. Langsenlehner R. Windhager

Introduction: Breast cancer is the most frequently diagnosed cancer in western countries and bone metastases of breast cancer cause significant morbidity. Tumor growth and progression requires the formation of new blood vessels, a process called angiogenesis. Angiogenesis is a complex multifactorial process involving a variety of proangiogenic and proteolytic enzyme activators and inhibitors. The most important regulator of angiogenesis is vascular endothelial growth factor (VEGF), which is overexpressed in several tumor tissues. The single nucleotide polymorphism 1498 C/T of VEGF was associated with increased plasma levels of VEGF. In this case controlled study, we analyzed the role of this polymorphism in bone metastasis of breast cancer.

Material and Methods: We genotyped 839 female breast cancer patients. The study was performed according to the Austrian Gene Technology Act and has been approved by the Ethical Committee of the Medical University Graz. According to breast cancer staging, patients were divided in three groups, representing patients without metastases (n = 708), those with metastases other than bone (n = 69), and those with bone metastasis (n = 62). Results: Frequency of the 1498 CC genotype of VEGF was significantly lower among patients with bone metastases (6.5%) than among those with other metastases (23.2%; p=0.005) or no metastases (23.4%; p=0.002). Odds ratio of the CC genotype for bone metastases was 0.22 (95% CI 0.08 – 0.61; p = 0.004). Conclusion: We conclude that the homozygous 1498 C genotype of VEGF may be protective against development of bone metastasis in breast cancer patients.


Thomas F. DeLaney

Background: Bone sarcomas are rare primary tumors. Radiation therapy (RT) can be useful in securing local control in cases where negative surgical margins cannot be obtained or where tumors are not resected. Recent technical advances in RT offer the opportunity to deliver radiation to these tumors with greater precision and accuracy, thus allowing higher doses to the tumor target with less dose to critical normal tissues, which can improve local tumor control and/or reduce treatment-related morbidity. Results of a recently published prospective trial of patients with spine sarcoma treated with high dose photon/proton radiation +/− surgery +/− chemotherapy will be presented to illustrate these concepts.

Methods: Eligible patients had nonmetastatic, thoracic, lumbar, and/or sacral spine/paraspinal sarcomas. Treatment included pre- and/or postoperative photon/proton XRT with or without radical resection; patients with osteosarcoma and Ewing’s sarcoma received chemotherapy. Shrinking fields delivered 50.4 cobalt Gray equivalent (Gy RBE) to subclinical disease, 70.2 Gy RBE to microscopic disease in the tumor bed, and 77.4 Gy RBE to gross disease at 1.8 Gy RBE qd. Doses were reduced for radiosensitive histologies, concurrent chemoradiation, or when diabetes or autoimmune disease present. Spinal cord dose was limited to 63/54 Gy RBE to surface/center. Intraoperative boost doses of 7.5 to 10 Gy could be given by dural plaque.

Results: A total of 50 patients (29 chordoma, 14 chondrosarcoma, 7 other) underwent gross total (n = 25) or subtotal (n = 12) resection or biopsy (n = 13). With 48 month median follow-up, 5-year actuarial local control, recurrence- free survival, and overall survival are: 78%, 63%, and 87% respectively. Two of 36 (5.6%) patients treated for primary versus 7/14 (50%) for recurrent tumor developed local recurrence (p < 0.001). Five patients developed late radiation-associated complications; no myelopathy developed but three sacral neuropathies appeared after 77.12 to 77.4 Gy RBE.

Conclusions: Local control with this treatment is high in patients radiated at the time of primary presentation. Spinal cord dose constraints appear to be safe. Sacral nerves receiving 77.12-77.4 Gy RBE are at risk for late toxicity. Similar approaches may be considered for other challenging bone and soft tissue sarcomas.


Y.M. Schrage I.H. Briaire-de Bruijn N.F.C.C. de Miranda A.H.M. Taminiau T. van Wezel P.C.W. Hogendoorn J.V.M.G. Bovée

Chondrosarcomas are notorious for their resistance to conventional chemo- and radiotherapy, indicating there are no curative treatment possibilities for patients with inoperable or metastatic disease. We therefore explored the existence of molecular targets for systemic treatment of chondrosarcoma using kinome profiling.

Peptide array was performed for 4 chondrosarcoma cell lines and 9 primary chondrosarcoma cultures. Acitivity of kinases was verified using immunoblot and active Src- and PDGFR signaling were further explored using imatinib and dasatinib on chondrosarcoma cell lines and primary cultures.

The AKT1/GSK3B pathway was clearly active in chondrosarcoma. In addition, the PDGFR pathway and the Src kinase family were active. PDGFR and Src kinases can be inhibited by imatinib and dasatinib, respectively. While imatinib did not show any effect on chondrosarcoma cell cultures, dasatinib showed a decrease in cell viability at nanomolar concentrations in 3 out of 5 chondrosarcoma cultures. Whereas inhibition of phosphorylated Src (Y419) was found both in responsive and non-responsive cells, caspase-3 related apoptosis was found only in cell line GIST882, suggesting that the mechanism of decreased cell viability in chondrosarcoma by dasatinib is caspase-3 independent.

In conclusion, using kinome profiling we found the Src pathway to be active in chondrosarcoma. Moreover, in the chondrosarcoma cell lines and primary cultures we showed that the inhibitor of the Src pathway, dasatinib, may provide a potential therapeutic benefit for chondrosarcoma patients which are not eligible for surgery.


G. Odri F. Lamoureux G. Picarda S. Battaglia S. Dumoucel V. Trichet F. Tirode K. Laud S. Burchill F. Gouin D. Heymann F. Rédini

The development of multidisciplinary therapy for Ewing’s sarcoma (ES) has increased current long-term survival rates to greater than 50%, but only 20% for patients with clinically detectable metastases at diagnosis, or not responding to therapy or with disease relapse. Anti-bone resorption bisphosphonates (BP) may represent promising adjuvant molecules to limit the osteolytic component of bone tumor.

The combination of zoledronic acid (ZOL) and ifosfamide (IFOS) or mafosfamide (MAFOS) was studied in ES models and in 8 human cell lines all expressing the EWS-FLI1 fusion gene. Cell proliferation, viability, apoptosis and cell cycle distribution were analysed. The ES models were developed in immuno-deficient mice by inoculating the human tumor cells either intra-muscular (soft tissue tumor development) or intra-osseous (bone tumor development). Mice were then treated with ZOL (100 μg/kg twice or 4 times/week) and/or ifosfamide (IFOS 30 mg/kg, one to 3 sequences of 3 injections).

All the cell lines studied were more or less sensitive to ZOL and MAFOS in terms of cell proliferation. Both drugs induced cell cycle arrest respectively in S and G2M phase and final apoptosis associated to caspase 3 activation. In vivo, ZOL had no effect on soft tumor progression although it dramatically inhibits ES development in bone site. When combined with IFOS, ZOL exerts synergistic effects in the soft tissue model leading to a similar quantitative inhibitory effect when associated with 1 sequence IFOS as compared to 3 sequences of IFOS alone. In the bone model, ZOL prevents tumor recurrence observed with a lonely sequence of IFOS.

Combination of ZOL with conventional chemotherapy showed promising results in both ES models and could allow the clinicians to diminish the doses of chemotherapy. Moreover, as ZOL and MAFOS induce cell death by different pathways, respective resistance may be circumvented.


M. Berta A. Cistaro C. Defilippi A. Linari M. Pagano E. Garrone A.M. Postini U. Albertini M. Mancini F. Fagioli A. Brach del Prever

PET/CT is successfully used in metabolic characterization of lung nodules in adult patients. An SUV max of 2.5 is generally accepted to distinguish benign from malignant lesions; for small solitary lung nodules some authors recommend visual evaluation rather than only SUV, suggesting that classical SUV criterion of 2.5 is inappropriate.

In pediatric patients interpretation of nodular opacity is still a clinical problem: specificity of CT in a pulmonary nodule, especially when small, is still limited.

Aim of this prospective study was to evaluate PET/ CT for non invasive characterization of pulmonary nodules in pediatric bone sarcomas.

Materials and methods: 56 whole-body PET-CT exams were performed in 19 patients with OS (14 female, 5 male) and 9 with ES (4 female and 5 male); median age at the first PET/CT exam was 14 years 8 months. PET/ CT results have been correlated with conventional imaging (CI), hystologic findings and clinical follow-up.

Results: PET/CT correctly identified pulmonary metastases, according with CI, in 33/56 exams (59%), PET/ CT revealed correctly “understaging” in 15 exams (27%) (10 in ES, 5 in OS) and incorrect “understaging” in 8 (14%) exams (4 in OS, 4 in ES). There were no false positive in either groups.

Conclusion: Correct diagnosis of a pulmonary opacity is fundamental for prognosis and choice of treatment in patients with doubtful lung lesions. Our preliminary results suggest the feasibility of a correct characterization by PET/CT in paediatric bone sarcoma patients. In particular PET/CT seems accurate and sensitive for lung nodules higher than 5 mm: an SUV max (and SUV ratio) higher than 1 seems to be significant when size is higher than 5 mm, while no significant SUV max (and SUV ratio) differences were found for smaller lesions.

Prospective studies are needed to clarify benefit of PET/CT in management of these patients.


D. Andreou S.S. Bielack D. Carrle M. Kevric S. Fehlberg R. Kotz W. Winkelmann G. Jundt M. Werner P. Reichardt P.U. Tunn

The development of local recurrence after multimodal treatment of osteosarcoma is associated with a very poor prognosis. The importance of clear surgical margins has been demonstrated in multiple studies, however up to date there are no studies defining which margin width is safe from an oncological perspective. The purpose of this retrospective analysis was to evaluate whether margin width or other surgical and tumour-related factors influence the development of local recurrence in osteosarcoma patients.

The files of 1867 consecutive patients with high-grade central osteosarcoma of the extremities, the pelvic bones and the shoulder girdle, who had achieved a complete surgical remission during combined-modality therapy on neoadjuvant Cooperative Osteosarcoma Study Group (COSS) protocols between 1986 and 2005, were reviewed. Of those, the data required were available for 1369 patients, who were the subject of this analysis. Eighty of these patients developed a local recurrence during the course of their illness.

The median surgical margin width amounted to 45 mm (range, 0 to 140 mm) in the local recurrence (LR) group and 50 mm (range, 0 to 350 mm) in the non-local recurrence (NLR) group (p=0.106). No statistically significant difference between the two groups was found regarding tumour size (mean, 10.38 cm and 9.53 cm respectively, p=0.169), T-status (p=0.225) and presence of pathological fracture (p=0.231). However infiltration of the soft tissue beyond the periosteum was documented in 58.8% of the patients with local recurrence and only in 36.9% of the rest (p=0.003). Furthermore, in 50% of the LR group the biopsy had been performed in a centre other than the one performing the definitive tumour resection, compared to 30.2% of the NRL group (p=0.001).

In conclusion, the absolute metric width of surgical margins does not define oncological safety. Local recurrence is more likely to develop in patients with soft tissue infiltration beyond the periosteum or those biopsied in a centre other than the one performing the tumour resection.


J. Hardes Ch. von Eiff A. Streitbürger M. Balke T. Budny M. Henrichs H. Ahrens

The use of megaprostheses is accompanied with periprosthetic infection in up to 15% of cases. Among metals with antimicrobial activity, silver has raised the interest of investigators because of its good antimicrobial activity. The aim of this study was to determine the infection rate of silver-coated megaprostheses in comparision to uncoated titanium prostheses.

We prospectively identified 40 patients who were treated with a silver-coated proximal femur (n=17) or proximal tibia (n=23) replacement (Mutars®, Implantcast, Germany). Patients with a silver-coated tumor endoprosthesis were compared with 74 (proximal femur replacement n=33, proximal tibia n=41) retrospectively assessed patients with a titanium endoprosthesis regarding the number of infections.

In the titanium group a proximal femur replacement was associated with the highest infection rate (18.2%; time of infection in mean 15 months postoperatively). In the silver-group infection could be reduced to 5.9% (time of infection 12 months postoperatively). In patients with a proximal tibia replacement the infection rate could be reduced from 17.1% (time of infection in mean 28 months postoperatively) to 4.3% (time of infection 4 months postoperatively) in the silver group.

Regarding the final, successful treatment of infection it can be stated that in the silver group the patients could be treated either by intravenous antibiotics only or by a one-stage exchange of the prosthetic body. In the titanium group seven patients (53%) were treated by a two-stage reimplantation of the prosthesis, in 4 patients (31%) an amputation and in one patient rotationplasty was performed.

We conclude that silver-coated megaendoprostheses can reduce the risk of infection on a short-term followup. Importantly, minor revisions in the case of infection in patients with a silver-coated prostheses were more often successful. Further studies with more patients and a longer followup are necessary in order to evaluate the possible benefit of silver exactly.


GU Exner CE Dumont Eva Harasta

Introduction: Joint sparing is a prerequisite for biologic reconstructions allowing for permanent healing in bone tumors. The physis not crossed by vessels in children can provide a safe margin for tumor resection. In selected patients we have performed joint sparing procedures either by transepiphysial resection or by epiphysial distraction as introduced by Canadell and San Julian.

Patients and methods: 8 children (1 ewing tumor, 8 osteosarcomas [1 multiple localizations]) with open physes 3 distal femurs, 6 proximal tibiae) were treated for metaphysial tumor localizations touching but not crossing to the physis. In 4 localizations epiphysial distraction was used, in the others transepiphysial resection. Reconstructions were performed with vascularized fibula alone in 4 cases, with vascularized fibula transfer and allograft in 1 patient, in the others only intercalary allografts were used.

Results: F/u is 3 to 12 years. No local recurrence occurred. One intercalary allograft failed for infection after irradiation; this was salvaged by a modified rotation plasty. One patient with fibula reconstruction of the femur needed reosteosynthesis due to lack of fusion with a finally excellent result at 3 years f/u, in one the fractured allograft needed be replaced by autologous bone following temporary cement spacer, but the epiphysis could be retained. All patients have excellent joint function. Shortness due to loss of the physis is corrected by contralateral epiphysiodesis and/or lengthening.

Conclusion: Epiphysial sparing tumor resection can be successful oncologically if patients are properly selected and surgery is respecting the tumor margins.


RJ Grimer SR Carter RM Tillman A Abudu L Jeys P Unwin

Aim: To investigate the effectiveness of silver coated titanium prostheses in preventing periprosthetic infection in a group of very high risk patients.

Methods: Periprosthetic infection is one of the main problems in limb salvage surgery, especially for tibial and pelvic prostheses or following revision surgery, particularly if it has been done for a previous infection. We have used silver coated prostheses in 21 cases on a named patient basis and have now assessed the results.

Results: Between July 2006 and June 2008 21 patients had a silver coated prosthesis inserted. 11 patients were having a second stage revision after a previous infection, 6 were having a pelvic prosthesis inserted, 3 were having a primary tibial replacement and one a one stage proximal tibial revision. Three patients developed a postoperative infection, two of the pelvic replacements and one infected revision (a total femur replacement). Of these only one patient required removal of the prosthesis (for overwhelming coliform infection in a pelvic replacement) whilst the other two infections both settled with antibiotics and washout.

Discussion: The anticipated risk of infection in this high risk group would have been around 20%. The actual infection rate was 14% but two of the infections completely resolved with relatively modest treatment. This suggests that the silver coating may not only have a role in preventing infection but also enhancing control of infection should it arise. There were no other side effects and we believe that these preliminary results are encouraging and should lead to a further evaluation of silver for preventing infection around prostheses.


P.C. Jutte S.K. Bulstra

In orthopaedic oncology surgical precision is important and intraoperative imaging is often necessary. CAS may enhance precision and provide continuous 3D imaging without radiation. The goal of this work is to report our experience with CAS.

Since 2006 we used CAS (Stryker) in 26 patients with a bone tumour: 11 chondrosarcomas, three osteosarcomas, seven osteochondromas and five miscellaneous. Twelve lesions were located in the femur, six in the pelvis, five in the lower leg and three in the upper extremity. In 18 cases a tumour was excised, in six of these a prosthesis was placed. In eight cases a curettage was done. In 23 cases the navigation was image-based (CT and/or MRI based) and in three cases image-less (no image-preparation necessary preoperatively).

CAS was successfully employed in 23 cases. In three cases the procedure was aborted. In two cases, both in the ulna, we were unable to reconstruct the exact dimensions and in one case (image-less) the tracker was to far away from the work-field. There were no complications related to CAS. Mean precision is 0.5 mm. The time CAS takes is about 15 minutes during the procedure (7–60). In the eight curettages it proved helpful. We did not measure radiation time. In the six resections were tumour-prostheses were placed it was really helpful in rotation and length determination. In three of these, image-less navigation was performed (all distal femur). In osteochondroma resections it is helpful in four of seven cases. All surgical margins were adequate in the resections; after curettage, all MRI controls at three months did not show residual tumour. Oncology follow-up is too short yet; there was one local recurrence after two years in a parosteal osteosarcoma.

We conclude that CAS can be our navigator in orthopaedic oncology; it is successful in providing precision and continuous 3D imaging. The indication area needs further study.


A. Leithner R. Windhager

Based on paleopathological findings there is evidence that primary malignant bone und probably soft tissue tumours accompanied mankind from the very beginning. Impressive findings of osteosarcomas have been reported from ancient Peru and medieval Hungary. Astonishingly a report exists on a 3rd century AD amputation of a leg affected by “cancer” and, even more amazing, on the successful reconstruction using a homologous limb transplant.

This “miracle” has been attributed to Saints Cosmas and Damian. According to the legenda aurea of Jacobo da Varragine the miraculous treatment of took place in 3rd century Rome. The saints amputated the leg of the Deacon Justinian and successfully transplanted the leg of a black African, who had died some hours ago. According to the legend the deacon was able to walk again and glorify his doctors. This legend inspired artists throughout the centuries as can be seen in a famous 16th century oil painting in Stuttgart’s Landesmuseum Württemberg. The twin saints Cosmas and Damian have been praised before for the first homoplastic limb transplant. The cause for amputation, however, was reported to be a “gangrenous leg” or a “diseased leg”. Looking at the original text of the legenda aurea, a different picture emerges, the cause for surgery being “cancer” of the leg – “…cui cancer unum crus totum còsumpserat”.

Also astonishing, at their time and in ours, the saints treated patients without taking any payment. It is not surprising that they were the most renowned of all medically inclined saints and were soon regarded as patron saints of medicine. From today’s medical view, neither resection margins according to Enneking nor a follow-up period were provided by the legenda aurea. It therefore remains elusive whether a local or systemic recurrence occurred. Nevertheless, Saints Cosmas and Damian may well be regarded as Europe’s first orthopaedic oncologists.


R. Dieckmann H. Ahrens J. Hardes T. Budny C. von Eiff G. Gosheger

Megaendoprotheses are widely used in the reconstruction of large bone defects in orthopaedic tumour surgery. The major complications (up to 36%) are periprosthetic infections. Persisting periprosthetic infections lead to secondary amputation up to 37% of the cases. One underestimated reason for persisting infections are subpopulations of S. aureus called “small colony variants” (SCVs). Aim of this study was to evaluate that silver ions might prevent or cure a periprosthetic infection caused by SCVs.

For testing the antimicrobial activity of silver-coated titanium we used a technique introduced by Bechert et al. Therefore an adhesion and proliferation assay was performed with clinical isolates of S. aureus SCV (A22616/3). We tested the adhesion and proliferation properties of S aureus SCV on stainless steel (steel), Cobalt-Chrome-Molybdenum-alloy (CoCrMo), Titan-Aluminium-Vanadium-alloy (TiAlVa) and silver-coated Titan-Aluminium-Vanadium-alloy (scTiAlVa).

Adhesion of S. aureus SCV is significantly reduced on scTiAlVa vs. steel (p> 0001). We could also demonstrate that the proliferation rate of scTiAlVa vs. all tested materials is significant (p> 0001) lower.

We concluded that silver-coating has an effective antimicrobial activity against S. aureus SCVs. Thus silver-coated megaendoprostheses are a good prophylaxis against persisting infections caused by S. aureus SCVs.


D. Campanacci A. Gonfiotti M. Ippolito M. Olivieri M. Innocenti A. Janni R. Capanna

Sternal resection is commonly performed for primary and metastatic chest wall tumours involving the sternum or the ribs near the sternum and, in case of wide resections, it is necessary to restore the stability of the chest wall. We analyze our experience with emphasis on surgical management and survival. From 2001 to 2007, 16 patients underwent surgical resection of the sternum for malignant lesions: 10 (62.5%) primary lesions (chondorsarcoma n=8; osteosarcoma n=2) and 6 (37.5%) secondary lesions (4 local recurrence from breast cancer and 2 metastases). We performed 12 partial resections (resected area from 65 to 20 %), 2 subtotal resections (about 90% of total area) and 1 total resection. Chest wall stability was obtained by prosthetic material, rigid and non rigid, and muscolar flaps. As non rigid material we used a polytetrafluoroethylene patch (Gore-tex Dual Mesh Plus) while replacement after total sternectomy was performed using a new rigid system of mould-able titanium connecting bars and rib clips (Strasbourg Thoracic Osteosyntheses System, Medxpert, GMbH). Prosthetic material was combined in 3 cases with a latissimus dorsi muscolar flap, in 1 case with a vertical rectus abdominis muscolar flap, in 12 with a pectoralis major flap. There was no perioperative mortality or significant morbidity. All patients were extubated within 24 hours after operation. At a mean follow-up of 44.1 months (range 82–14), 5 years actuarial survival for primary tumours was 85%, while 3 years actuarial survival after resection of secondary tumours was 39% (median 20,5 months). In case of primary lesion wide resection with tumour-free margins is necessary to minimize local recurrence and to contribute to long-term survival; reconstruction with a rigid system composed of mould-able titanium bars and rib clips allows to plan extensive demolition minimizing the risk of chest wall instability. In metastatic disease surgery can provide good palliation, although survival is poor.


M.D. Aliev D.V. Nisichenko S.A. Saravanan M.N. Orekhov P.S. Sergeev A.A. Babalaev V.A. Sokolovskiy

From 1992 on 2008, 615/515 patients underwent primary or revisional endoprosthetic replacement of major joints. In 51 patients (31 men & 20 women) modular system MUTARS (Implantcast, Germany) has been used. The median age was 23.3 years (15 to 52 years).

MUTARS modular endoprosthesis has been used in 10 patients with deep infection of endoprosthetic bed as a revisional endoprosthetic replacement: 1 Total endoprosthetic replacement of femur, 5 Total knee joint replacement (2 for distal femoral defect and 3 for proximal tibial defect). In 3(27%) patients, we used newly patented silver ion coated MUTARS either after two stage treatment for infection of endoprosthetic bed or as a prophylaxis of endoprosthetic infection.

In 1 patient (23 yrs), with 12cm limb length shortening, we used extensible MUTARS as a revisional endoprosthetic replacement.

The following complications we observed: Instability of endoprosthesis – 3/51 (5.9%), deep endoprosthetic bed infection – 4/51 (7.8%).

In comparison group, when using custom-made endoprosthesis, the frequency of infectious complications have made 60/574 (10.5 %), and instability of implants was observed in 79/574 (13.8 %) cases.

Transition of using modular systems for primary and revisional endoprosthesis allows to reduce the level of instability from 13.8 % to 5.9 %. The quantity of infectious complications is also not great as in comparison with control group. For revisional endoprosthetic replacement, we think, the given modular system is optimal, for correcting limb length deficiency and restoration of basic function at patients. Use of silver ion coated modular implants is a promising method for treating deep endoprosthetic bed infection.


A. Peyser Y. Applbaum N. Simanovsky O. Safran R. Lamdan

Radiofrequency (RF) ablation carries success rate of 70–90% in the treatment of Osteoid Osteoma (OO). Failures are related to incomplete ablation which might be caused by the probe’s small heating radius (0.5–0.8 cm). Water cooled tips were developed in order to prevent charring of the tip and adjacent tissues and to allow for a larger, up to 3cm ablation diameter. To our knowledge safety and efficiency of this probe in the treatment of pediatric OO were never reported. Our goal was to examine if this technique, when added to conventional RF ablation, improves the clinical results and whether it carries any additional risks in the pediatric population.

Twenty two OO patients, 15 males and 7 females, 3 years and 6 months to 18 years old, were treated using the Cool-tip™ Tyco probe in a cooled mode followed immediately by conventional RF cycle under general anesthesia, in the CT suite. Fifteen of the lesions were in the femur, 2 in the tibia and the remainder lesions were located in the humerus, talus, calcaneus, 2nd metatarsus and sacrum. The OO was intraarticular in 5 patients: femur (3), calcaneus and Talus. Follow-up period averaged 38.5 months (range 16–66 months). All patients but one had their symptoms resolved immediately following a single treatment (95.5% success rate). One patient had partial relief and underwent second successful ablation. There were one recurrence after 18 months and one superficial infection. No fractures, neurovascular complications or growth disturbances were encountered.

We conclude that the addition of a Cool-tip cycle to conventional RF ablation in children is safe, efficient and reduces the risk of recurrence without adverse effects specific to this age group. We attribute this success to the larger diameter of heat distribution occurring due to cooling of the tip and the prevention of probe and tissue charring.


Jose Casanova João Corte Real Marco Lucas Pedro Carvalhais Alexandre Marques João Freitas Antònio Laranjo

Introduction: Most of the bone metastases have origin in breast, lung, prostate, thyroid and kidney neoplasms. The commonest locations are the axial skeleton and the proximal region of the long bones, being the femur the most affected one. The main objectives of the surgical treatment are a quick functional recuperation and immediate pain relief.

Objectives: The aim of this work was to define a strategy for the surgical treatment of the bone methastasis located in the femur.

Material: The study includes 94 patients with femoral methastasis (100 metastasis) surgicaly treated in the last 10 years in our department.

Methods: Retrospective descriptive study based on medical records evaluation.

Results: The proximal third of the femur was involved in 80 % of the cases. Pathological fracture was identified in 72 cases and impending fracture in 28. Half of the primitive neoplasms was originated in the breast. It was identified as solitary metastatic lesion only in 33 % of the situations. The mean patient survival time was 9,2 months. They were treated with a cemented calcar-replacing prosthesis in 40 patients, 10 patients submited to conventional arthroplasty and 36 with intramedullary fixation (usually a cephalomedullary nail). The remainder 14 were treated with other surgical techniques.

Discussion: The surgery is indicated in case of painful lytic injury or unresponsive to radiotherapy, pathological or impending fracture. The surgical technique depends on the location and size of the lesion and if it is a solitary or multiple bone lesion, choosing between arthroplasties, of preference with long femoral stem, and intramedullary fixation. As we have performed a retrospective study, a functional rigorous evaluation was not possible.

Conclusion: The treatment of metastatic femoral disease is not performed with the intention of cure but to improve significantly the patient’s life quality. The proximal third of the femur is the most reached place. Breast cancer was responsible for around 50 % of the cases. In 50% of the patients the surgical option was an arthroplasty and techniques of femoral nailing were performed in 36%. The cemented replacement prosthesis is used in proximal large injuries with periarticular involvement: The intramedullary fixation is reserved for situations in which the femoral head and neck are not involved. The length of patient survival must exceed the predictable surgical recovery period.


J. Friesenbichler A. Leithner M. Glehr R. Windhager

Introduction: Rotating hinge knee prostheses are designed to provide a stable knee reconstruction when the intrinsic soft-tissue stability of the knee had been lost as a result of tumor resection, multiple knee replacements, trauma or surgical reconstruction. Instability is the main risk factor for implant’s dislocation. We performed a biomechanical analysis to establish the association between design of the central rotational stem (length and taper) and the implant’s stability, using a self constructed biomechanical apparatus on a test bench in the laboratory.

Materials and Methods: The lengths and tapers of the central rotational stem of three different rotating hinge knee implants (LPS/M.B.T. (DePuy)-cylindrical, length: 46mm, taper: 0°; S-ROM Noiles (DePuy) -conical, length: 46mm, taper: 5°; GMRS (Howmedica) -cylindrical, length: 47mm, taper: 0°) were measured using a self-constructed biomechanical testing device. The degree of tilting of the central rotational stem within the vertical post-in channel by extending the distraction was measured as well the maximum amount of distraction before the stem’s dislocation.

Results: The GMRS implant design was superior to the LPS/M.B.T. and the S-ROM Noiles implant design concerning stability and maximum amount of distraction before dislocation (38 vs. 27 vs. 26 mm). The GMRS system had a steep rising distraction-angular displacement curve until the dislocation at 38mm occurred while the laxity curve of S-ROM Noiles showed a poor increasement. Besides early high laxity it required only 26mm of distraction to dislocate.

Conclusions: Our conclusion is that rotating hinge prostheses with a short and markedly tapered central rotational stem have the highest instability/angular laxity at any given amount of distraction. Such knee prostheses should be used with caution in patients after excessive soft tissue resection. A long and cylindrical central rotational stem seems to prevent early instability and implant’s dislocation.


P.S. Rose M.J. Yaszemski M.B. Dekutoski P.M. Huddleston A. Nassr T.C. Shives F.H. Sim

Curative treatment of malignancies in the sacrum and lower lumbar spine frequently requires en bloc spinopelvic resection. There is no standard classification of these procedures. We present outcomes and a classification scheme with oncologic and reconstructive guidelines for spinopelvic tumors based on an analysis of 30 cases of en bloc resection and reconstruction performed with curative intent.

Mean follow-up of surviving patients was 38 months. Tumors included osteosarcoma (n=9), chondrosarcoma (n=6), chordoma (n=5), other sarcomas (n=5), neurogenic tumors (n=4), and local extension of carcinoma (n=1). Resections could be divided into 4 types. Type 1 resections (n=12) included a total sacrectomy with lower lumbar spine and bilateral medial iliac resections. Type 2 resections (n=6) included hemisacrectomy, partial lumbar spine excision, and medial iliac resection. Type 3 resections (n=9) encompassed external hemipelvectomy with hemisacrectomy and partial lumbar spine excision. Type 4 resections (n=3) encompassed external hemipelvectomy, total sacrectomy, and lumbar spine excision.

For each resection type, we have developed staged surgical approaches to allow resection with wide margins and reconstruction of spinopelvic continuity. Tumor free margins were achieved in all cases. Perioperative mortality was 3/30. Seven additional patients have died of disease, two died of other causes, two are alive with disease, and 16 have no evidence of disease. 13/18 surviving patients are independent in their activities of daily living.

In our practice en bloc excision and reconstruction of spinopelvic neoplasms may be classified into four types. For each type, we have devised surgical treatment guidelines to allow for wide resection and reconstruction of spinopelvic continuity. Long term survival and independent function can be achieved in this challenging patient population. This represents the first standardised classification of oncologic spinopelvic resections and reconstructions.


Kh.G. Abdikarimov M.A. Gafur-Ahunov U.F. Islamov F.E. Nasritdinov K.Z. Iskandarov B.Sh. Karahojaev

We observed the 55 patients with local spread tumours of bones and soft tissues of shoulder girdle. There were 43 (78,2%) men, 12 (21,8%) women; the average age was 38,8. In 23 patients the tumour became localized into proximal part of humerus, 2 were in lateral end of clavicle, 4 were in shoulder blade, 18 were in soft tissues of upper two thirds of shoulder, 4 were in soft tissues of axiila, 3 were in soft tissues of shoulder blade and 1 was metastases of sarcoma of forearm soft tissues in armpit lymph nodes. In 8 cases the bone tumours were presented with osteosarcoma, 12 – hondrosarcoma, 5 – malignant giant celled tumour, 1 – Ewing’s sarcoma, 1 – reticulosarcoma, 2 – fibrosarcoma of bone. Among tumours of soft tissues, the fibrosarcoma and synovial sarcoma prevailed over 10 and 8.

Regard for local spread of tumour and degree of anatomical structures drawing in process, 47 patients performed interscapulothoracic amputation and 8 were interscapulothoracic resection (Tikhoff-Linberg operation). In pre- and post operative period the chemical and/or radiotherapy were performed in 43 patients. Selection the scheme and regimen of treatment depended on histological type of tumour.

The dates of observation were from 6 month to 14 years. The acute disorder of cerebral blood circulation was developed in one patient after interscapulothoracic amputation in early postoperative period. The local recurrence of tumour was revealed in 4 patients (8,4%) after interscapulothoracic amputation and in 3 patients (37,5%) after interscapulothoracic resection, in 14 (29,7%) and 4 (50%) were metastases conditionally. All patients had local recurrence in soft tissues. In 2 patients with local recurrence the amputation of extremities were performed.

There fore, the interscapulothoracic resection is used in local spread tumours of proximal part of humerus, shoulder blade, acromical part of clavicle and soft tissues of shoulder girdle, with some anatomical structures involved in process, but without affection of vascular-nerve fascicules. Involving in tumor process vascular and nerve plexus are statement for performing interscapulothoracic amputation.


M.A. Gafur-Akhunov Kh.G. Abdikarimov U.F. Islamov F.E. Nasritdinov R.R. Abdurasulov

The results of treatment of 45 patients with malignant bone tumors and soft tissues of thigh proximal part and pelvis have been analyzed in the work. From 45 male patients −37 (82%), women −8 (18%). Patients’ age varied from 17-to 53 years old, in average was-33 year old. In 22 patients the tumor localized in thigh proximal part, in 17 – in the bone and soft pelvic tissues, in 2- in the buttock part and in 4- noticed metastasis lesion inguinaliliac lymph nodes. In 5 observations histological type composed from malignant gigantic cellular tumor, in 8 osteogen sarcomas, in 11-hondro-sarcomas, in 5-Ewing’s sarcomas, in 4 – fibrosarcoma of soft tissues, in 4-rabdomiosarcomas, in 1- angiosar-coma of soft tissues, in 1-leiomyosarcomas, in 1-synovial sarcomas, in 1- polymorph cellular sarcomas of soft tissues and in 4- marked metastasis lesion (mainly flat cellular skin cancer) lymph nodes of inguinal-iliac part. The complex diagnostic measures including clinic, X-ray and ultrasound diagnostics, angiography, computed magnetic – resonance tomography and morphologic investigations were carried out with all patients.

A size of tumor process is 250–450cm3. In all cases carried out lymph dissection with removing of cellular tissue of pelvis till bifurcation of abdominal aorta, in 5 additionally are made sacrum resection. Duration of operational interference was from 150 to 189 minutes, and blood lost – from 1200 to 1800 ml. There were no mortality outcomes during the operation. The patients have been observed from 1 year till 12 years. During observation period from 45 patients in 4 (8%) have been determined local recurrence, in 12 (26%) – separated metastasis and in 2 (4%) –simultaneously determined recurring and separated metastasis. Findings of 3 and 5 years survival are 44,6% and 33,5%.

So, interpelvic-abdominal amputation prolongs patients’ surveillance, which before is considered hopeless and mainly undergone palliative chemotherapy and symptomatic treatment.


P. Cardoso M. Massada D. Freitas A. Pereira J. Sousa

Core needle: From the other 335, 116 were benign tumours or tumour-like conditions, 86 primary malignant, 53 lesions oh Hematopoietic, lymphoid and biopsy is simple, practical and easily permits diagnosis of bone and soft tissue tumours and tumour-like conditions even when immunohistochemical studies are needed.

We present the results of 412 core needle biopsies guided with fluoroscopy, CT and echo scan with assessment of accuracy and costs

From January/96 to December/08, 56 soft tissue and 356 bone tumours and tumour-like lesions were submitted to this technique in the Oncology Unit of Hospital Santo Antònio. All biopsies were performed by the same team (one radiologist, one orthopaedic surgeon) and the histological exam by the same pathologist.

There were 77 cases in which diagnosis was inconclusive (sample not representative, crushing, necrosis, hemorrhagic features or image/histological dissociation); 36 of these were soft tissue and 41 bone lesions. histiocytic elements, 65 metastases, 8 recurrent malignancies, 5 osteomyelitis and 2 metabolic diseases.

Diagnosis was confirmed in 278 cases with the definitive surgery and only one was wrong. The other 57 cases were later controlled by imaging exams and there were no reasons to suspect a wrong diagnosis.

No complications occurred.

Costs were estimated to be less than one fifth of an open biopsy.

The high accuracy (only one case was misdiagnosis), the safety, the costs and the fact that in only 18,7% the diagnosis was not established make us consider this method effective and to be encouraged. Better selection of lesions and more attention to directions of the cores may low the number of inconclusive diagnosis.


PC Jutte P Robinson L Kim SK Bulstra

In oncological resections there is a higher risk of infection around the foot and ankle. An infection here can be difficult to treat and easily lead to an amputation due to the limited amount of soft tissue coverage of the region. In three patients an infection developed after resection of a bone tumour in the foot and ankle.

In the first case, female 34 years, an epitheloid hemangioepithelioma was excised from the anterior part of the calcaneus, cuboid and lateral os cuneiform. An iliac crest graft was initially used to fill the defect, but got infected. The antibiotic loaded bone cement spacer cured the infection and filled the dead space but was painful. A free vascularised fibula with skin-flap was used successfully to fill the defect and take away the pain. At three-year follow-up there is no pain and full weight bearing, with a nice hypertrophy of the graft. In the second case, a 14-year old girl, there was an Aneu-rismal Bone Cyst (ABC) of the distal tibia with a deep infection after ethibloc injection. The vacuum assisted closure cleaned the wound but a defect resulted. It was successfully filled with an ipsilateral free vascularised fibula with skin-flap. Follow-up shows full function and nice hypertrophy at 24 months. In the third case, male 65 years, a chondrosarcoma grade one (after biopsy) in the cuboid was curetted out. It proved grade two in the definitive histology and furthermore it got infected. The cuboid was excised and a cement spacer was placed. The soft tissues were insufficient to close it properly. A free vascularised fibula with skin-flap was used. The vascularity of the graft was insufficient and the skin-flap did not survive. A vacuum assisted closure was done. He can bear weight and has no pain. The fibula graft is shows some hypertrophy and a fistula persists for 18 months now.

We conclude that vascularised free fibula with skinflap can successfully prevent amputation in case of infection in oncological resection of foot and ankle. The fibula reconstructs the bone defect and the skin-flap the soft tissue defect.


P. Cardoso M. Massada D. Freitas A. Pereira J. Sousa

Osteoid osteomas are benign, painful osteogenic tumours of small size (≤ 1,5 cm). Surgical resection of the nidus has been the elected method of treatment for decades but some complications and difficulties (poor localization, extensive tissue damage, fractures, delayed recovery) encouraged the development of less invasive techniques such as radiofrequency.

Lack of histological proof is the major concern regarding radiofrequency ablation as we make the diagnosis by the clinical findings and the image features.

We present the results of 20 patients with osteoid osteoma treated with radiofrequency from January 2004 to December 2008 (mean follow up 23 months). All patients were under general anaesthesia and de access route was chosen in the CT-suite. 11 cases were located in the proximal femur (head, neck and subtrocanteric region), 2 in the distal femur, 2 in de distal humerus, 2 in the tibia, 2 in the acetabulum, and 1 in de vertebal body of D8.

In all cases we used a Cool-tip TM RF electrode (water-cooled tip) reaching a heating temperature of 42°C to 48°C during 12 minutes. In 7 patients a cannulated drill bit was used to penetrate the thick cortical or to reach the nidus through the opposite side in order to avoid a neurovascular bundle.

Hospital discharge was allowed after 6 to 8 hours after the procedure.

No complications occurred.

All patients, except one, experienced complete relief of the pain although the 6-month follow-up CT’s do not show sclerosis of the nidus. None of them recurred till data. The patient who did not recover had not had a clear diagnosis.

We conclude that radiofrequency ablation is effective, safe, favouring rapid recovery and, of course, reduces economical and social costs.


F. Eckert M. Weinmann C. Belka M. Bamberg W. Budach

Standard therapy for soft-tissue sarcomas remains complete resection, irresectable tumours or tumours after resection with gross residual disease are a special challenge. For primary radiotherapy with median 60 Gy local control rates of 30–45% have been reported. We analysed retrospectively 11 cases of radiochemotherapy with single-agent Ifosfamide in patients with macroscopic soft-tissue sarcomas.

The patients were treated in irresectable high risk situations: T2-tumours (100%), G3 (73%), localisation at the trunk (82%). Radiation therapy was performed with median 60 Gy (50 to 72.6 Gy) in 1.8–2.0 Gy single fraction dose, once daily, five times a week. During the first and fifth week the concommittant chemotherapy with 1.0/1.5 gr/m2/d Ifosfamide on five days was added. Two patients received trimodal therapy with additional hyperthermia. The therapy was completed in 73% of the patients. Average local control time was 91 months, median disease-free-survival/overall-survival was 8/26 months. Five-year rates for local control/disease free survival/overall survival were 70%/34%/34%. Long-term tumor control could be achieved in three patients. The median disease free survival is dependant on the histological tumor grading (21 vs 8 months for G2 vs G3 tumors, no statistical significance due to small patient numbers). The limited prognosis is mainly caused by systemic treatment failure.

Concomitant radiochemotherapy with Ifosfamide in patients with macroscopic soft-tissue-sarcomas yields a good local control rate of 70% compared to previously published 30% in definitive radiotherapy with similar radiation doses. Additional simultaneous chemotherapy should be considered for irresectable soft tissue sarcomas or tumors after resection with gross residual disease, if the applicable radiation dose is limited due to close vicinity of organs at risk. A decrease of systemic failure with additional chemotherapy might be speculated.


L. McCullough J.D. Holmes R.R. Jeffrey D.E. Boddie

Chondrosarcoma is an uncommon primary malignancy of cartilage. This tumour tends to be resistant to both chemotherapy and radiotherapy making surgical resection the primary treatment. These tumours can present on the chest wall, requiring multidisciplinary team input at the time of surgery, involving orthopaedic, cardiothoracic and plastic surgeons. Complete excision, ensuring adequate resection margins, requires removal of ribs and pleura resulting in a full thickness chest wall defect. Complex reconstruction techniques are necessary to prevent post-operative morbidity of chest wall indrawing and reduced pulmonary function. Reconstruction can be considered in two parts, the reconstruction of the rigid support and the necessary soft tissue cover. In the past a number of options have been available to provide the rigid support, marlex sandwich, prolene mesh and autologous bone grafting. Each of these techniques has potential disadvantages.

We describe two patients who underwent resection of chest wall chondrosarcomas. These patients had reconstruction of the rigid chest wall support using STRATOS (STRASBOURG Thoracic Osteosyntheses System). This system utilises clamps around the cut ends of the ribs to provide the necessary rigid support, eliminating some of the disadvantages of the older techniques. Both patients made an uncomplicated post-operative recovery.

The STRATOS implant was easily used and versatile, providing an immediately secure and rigid fixation in chest wall reconstruction.


Full Access
R. Schwarz D. Carrle M. Kevric S. Bielack

The experience of radiotherapy (RT) in the local treatment of osteosarcoma (OS) is limited. Data of 100 patients with RT for OS from the international COSS-Registry (1980–2007) were analysed. Survival and local control rates at five years were calculated. Univariate and multivariate analyses were performed.

The COSS-registry includes 3500 patients with histo-logically proven OS. A total of 175 patients were irradiated over the period of 1980 to 2007, 100 patients were eligible. Median age was 18 (3–66) years. Indication for RT was a primary tumor in 66, a local recurrence in 11 and metastases in 23 patients. 94 Patients got external photontherapy, 2 pats. protontherapy, 2 pats. neutrontherapy, and 2 pats. intraoperative RT. Seventeen patients received a samarium-153-EDTMP therapy. Median dose for external RT was 55.8 Gy All patients were treated with chemotherapy in accordance to different COSS-protocols.

Median follow-up is 1.5 (0.2–23) years. Overall survival rates at 5 years for the whole group, for treatment of primary tumours, local recurrence, and metastases are 36 %, 55%, 15%, and 0% respectively. Local control rate for combined surgery and RT is significantly better than for RT alone (48% vs. 22%, p=0.002). Local control for treatment of primary tumours, local recurrence, and metastases are 40%, 17%, and 0% respectively. Prognostic factors for survival are indication for RT, RT plus surgery vs. RT alone and localisation. Prognostic factors for local control are indication for RT, and RT plus surgery vs. RT alone.

Radiotherapy is an important option for local treatment of unresectable OS, after intralesional resection, or symptomatic metastases. Survival prognosis of these patients is poor. Combination of surgery, radiotherapy, and chemotherapy can be curative. Prognostic factors were identified.


V.I. Sakellariou A.F. Mavrogenis P.J. Papagelopoulos

Six patients underwent wide segmental resection and limb salvage surgery for primary or metastatic bone tumors involving the diaphysis of the femur, the tibia and the humerus using a modular intramedullary diaphyseal segmental defect fixation system. There were 4 men and 2 women with a mean age of 62 years (range, 40 to 77 years).

Histological diagnosis included adamantinoma, dedifferentiated synovial sarcoma attached to the tibia, multiple myeloma, and metastatic renal cell carcinoma, myeloid carcinoma of the thyroid gland and metastatic adenocarcinoma of the stomach.

The mean follow-up was 16 months (range, 11 to 24 months). At the latest examination, 5 patients were free of local or distant disease; one patient had deceased with distant disease, without evidence of local recurrence. Revision surgery was necessary in one patient because of mechanical loosening of the proximal fixation of the prosthesis. The mean increase of the Enneking rating from the pre to the postoperative status was 87.82%.

The intramedullary diaphyseal segmental defect fixation system used herein is associated with a satisfactory functional and oncological outcome after wide resection of diaphyseal bone tumors.


N.M. Mandel F.O. Dincbas O. Yetmen D.C. Oksuz F. Ozyer S. Dervisoglu K. Kanberoglu H. Turna G. Demir S. Koca M. Hız S Ustundag

Our purpose was to assess the role of preoperative radio-therapy +/− neoadjuvant chemotherapy in nonmetastatic soft tissue sarcoma of extremities for limb-sparing surgery and identify the role of neoadjuvant therapies on local control and survival rate.

Forty-seven patients with soft tissue sarcoma of extremities who were treated at Cerrahpasa Medical Faculty within a limb salvage protocol, including preoperative radiotherapy +/− chemotherapy were retrospectively analized. Median age was 45 years (17–72 years). The tumor size was between 5–33 cm. Seventeen patients were in stage I, 11 in stage II, 19 in stage III. The most common histology was synovial sarcoma. Nine patients were treated for locally recurrent tumour. The tumour and surrounding tissues with probable microscopic tumour involvement observed clinically and radiologically, were irradiated. Thirty-two patients, with a high grade tumour and/or tumours larger than 8 cm, also received neoadjuvant chemotherapy. Neoadjuvant chemotherapy regimen was consisted of doxorubicine and ifosphamide with mesna. Preoperative radiotherapy was applied, usually between the second and third cycles of chemotherapy. Definitive surgery was administered 2–6 weeks after radiotherapy or after the third cycle of chemotherapy. Chemotherapy was completed to 6 courses after the surgery. Postoperative external beam radio-therapy boost of 16 Gy was given who had close or positive surgical margins. Median follow-up time was 67 months (12–217 months). All of the patients had limb-sparing surgery. Patients had; 30 marginal excision, 13 wide local excision, 4 radical resection. Nine patients locally recurred. Limb-sparing surgery was performed for 8 patients. 25 patients had distant metastases. Metastasectomy were applied for 10 patients with lung metastasis. The 5-year local control, disease free survival and overall survival rates were 82.3%, 50.1% and 67.2%, respectively.

Preoperative radiotherapy +/− chemotherapy seems to increase the chance of extremity-sparing surgery with good local control and the survival rates which were comparable with the literature.


T.F.E Barth K. Huch M. Schultheiss A. von Baer G. Haerter B. Grüner A. Essig H. Reichel F. Gebhard T. Wiegel H.J. Brambs P. Möller H. Döhner R. Mayer-Steinacker

We report on a patient with an unusual pulmonary infection after resection of a high-grade osteosarcoma. In March 2007 a 30-year old female with pain and swelling of the left proximal humerus was submitted to the orthopaedic department. Rx and CT revealed a tumour with destruction and invasion of the surrounding soft tissue.

Incision biopsy led to the diagnosis of osteoblastic osteosarcoma. She was enrolled into the EURAMOS protocol and received neoadjuvant chemotherapy. In July 2007 an extra-articular resection of the proximal humerus with modular endoprosthetic replacement was performed. The sarcoma had responded well to chemotherapy (regression grade 3 according to Salzer-Kunts-chik). Surprisingly, the resection specimen demonstrated a “skip lesion” of vital sarcoma in the resection line not been detected by preoperative PET or MRT. After consultation of the German study group she was stratified into the standard risk group.

12 months later a control CT revealed multiple foci in both lungs, which were highly suspicious for pulmonary metastases. All clinical parameters were normal. A lung biopsy was performed by thoracotomy and a granulomatous infection was diagnosed, which was suspicious for tuberculosis. Extended microbiological investigations by culture and PCR analysis revealed an infection by Myco-bacterium Xenopi, which is a rare form of an atypical mycobacteriosis. Since then she is treated accordingly, however the infection has progressed and involvement of the liver has been diagnosed by cutting needle biopsy.


E.E. Engel H.F. Oliveira M.H. Nogueira-Barbosa M.N. Simão C.A. Scridelli B. Mori

Extracorporeal Irradiation and Reimplantation (EIR) of tumor bearing bone segments is an alternative reconstruction method for major osseous resections. In contrast with endoprosthetic reconstruction, EIR is a biologic solution and after a prolonged healing and remodeling period it is expected to create a structural and metabolic almost normal bone.

After oncologic resection the bone segment is cleaned from adhered soft tissues and send to irradiation which kills malignant and normal cells. Reimplantation consists of fixation, mostly by plates, vascularised fibular graft insertion in the medullary canal, iliac bone graft in critical sites and ligamentous sutures.

Since 2001 fifteen patients were submitted to EIR in our institution. Resections affected seven distal femurs, four proximal tibias, one acetabulum, one iliac bone and the proximal forehand bones once which bear 11 osteosarcomas, 2 Ewing’s sarcomas, 1 chondrosarcoma and 1 rhabdomyosarcoma. There were six males and nine females with age ranging from five to 55 years. Ten patients were submitted to osteoarticular reconstructions, three to intercalary and two to partial pelvis reconstructions.

Local recurrence leading to amputation occurred in one patient and resection of an infected innominate bone occurred once. Three patients died two to nine months after surgery because of their disease. Five patients had metaphyseal fractures after one to 14 months after surgery. Four patients had no fracture; three of them had intercalary resections. The patient with osteoarticular resection and no fracture had his metaphyseal region injected with cement which prevented fracture and after 23 months have not developed osteoarthritis.

All the cases in which a vascularised fibular graft was implanted progressive fusion of the living and dead bones were observed.

As a conclusion EIR is a good alternative for intercalary resections. For osteoarticular resections improvement of the method are necessary to prevent fracture and ligamentous laxity.


E.F. Dierselhuis P.J.M. van der Eerden A.J.H. Suurmeijer P.C. Jutte

Radio Frequency Ablation (RFA) is a precise CT-guided technique to generate a small pre-defined field of dissecated tissue. Its’ present use in orthopaedic oncology is to treat osteoid osteoma. We have also treated other lesions with RFA and want to report our present indications and complications.

From 2005 to 2008 we performed 30 procedures: 23 osteoid osteomas, five low-grade chondrosarcomas, one chondroblastoma and one thyroid metastasis. Localisations were femur in 14 cases, tibia in 10, calcaneus in two, fibula in two, sacrum in one and scapula in one. All patients were treated with CT- guided RFA (Boston Scientific).

Follow-up for osteoid osteoma was done without additional imaging, all patients but one were pain free within 2 weeks; this one patient proved to have a chronic osteomyelitis although we thought we saw a nidus on CT. In one patient a burn wound complicated treatment because of unnoticed damage of the isolation layer of the probe. A free skin graft was necessary. We performed MRI controls and curettages for the chondrosarcomas in three patients, in one patient a fracture developed in the calcar femoris region after three months and a hip replacement was done. The patient with chondroblastoma is followed by MRI and there is no activity on contrast MRI two years after the procedure. In one lady a RFA was done for thyroid metastasis in the calcar femoris region. She fractured her collum femoris and got a hip replacement. In all tissue retrieved after RFA (curettage and hip replacement), there was complete necrosis of the tumour (chondrosarcoma grade one and thyroid metastasis).

RFA is an effective procedure for osteoid osteoma. Fracture and skin burns can occur. It is promising in low-grade chondrosarcoma and chondroblastoma. A study has been initiated recently to evaluate effectiveness of RFA in low-grade chondrosarcoma < 4 cm.


H. Nouri K. Mrad L. Abid M.H. Meherzi H. Jaafoura M. Mestiri

Articular invasion by malignant bone tumours around the knee is one of the most important criterions to determine prior surgery. MR imaging is the most accurate exam in staging bone sarcomas. Although, past studies showed that when MRI shows evidence of intra articular involvement by tumour, the incidence of false positive diagnosis and subsequent excessively radical surgery is as high as 50%. The aim of this study is to determine growth pattern of bone sarcomas into the joint in order to assess which are the limits of the joint compartment.

We reviewed retrospectively 18 cases of primary intra medullary sarcomas with epiphyseal extension located around the knee. The tumour was located in the distal femur in 11 cases and in the proximal tibia in 7 cases. In tumours located in the distal femur, two distinct modes of extension towards synovium and joint space were identified. The most common pattern was tumour growth along the anterior and intra articular part of the distal femur. This pattern was observed in 10 cases. The tumour displaced anteriorly soft tissues and remained extra synovial in 6 cases. Only in 4 cases, tumour contaminated the joint space. The extension was in all cases marginally close to the cartilage of the trochlea in the transitional zone between cartilage and synovial membrane.

The second pattern was extension through the inter condylar notch which was observed in three cases. Growth was around the osseous-tendinous junction of the cruciate ligaments and never within the ligament.

In tumors in the proximal tibia, although tumour was close to the osteochondral junction, cartilage was not breached anyway. Tumour got around the cartilage. Extension of the tumour to the articular joint was marginally under the posterior capsule insertions making contact with the edge of the articular cartilage. This pattern was observed in two cases. We didn’t observe an erosion of cartilage layer, in the limits of the sections done.

Our study, demonstrated that cartilage and synovial membrane, since they are not breached, represent reliable margins for intra articular resections. We identified in the current study, one mode of tumour extension towards synovium and joint space. In all cases, extension was in junctional zones between cartilage and synovial membrane or cartilage and articular capsule. The articular cartilage was the most resistant barrier, having no vascular perforations and probably an intrinsic resistance to tumour.


J.K. Anninga E.P. Buddingh M.I.M. Versteegh A.H.M. Taminiau A.C. Lankester R.M. Egeler P.C.W. Hogendoorn H. Gelderblom

Resection of pulmonary metastases has previously been reported to improve outcome in high grade osteosarcoma (OS) patients with pulmonary metastases. In this study factors influencing survival in OS patients with pulmonary metastases were determined.

One hundred ninety seven patients with OS treated at our institution between 1990 and 2008 under the age of 40 were included. Excluded were patients with insufficient follow-up data (n=12) and irresectable primary tumour (n=11). Of the 174 remaining patients, 26 patients had pulmonary metastases at diagnosis and 62 developed pulmonary metastases during follow-up. Twenty-two of 88 patients (25%) also had extra-pulmonary metastases. Almost all patients with primary non-metastatic OS who experienced a relapse within 310 days (first tertile) died of disease, whereas patients with a relapse free interval of more than 310 days (second and third tertiles) have a significantly better overall survival at about 20% (p=0.02).

In total, 56 (63.6%) of 88 patients with pulmonary metastases were treated by metastasectomy. The main reason not to perform metastasectomy was irresect-ability by number and site. Patients with irresectable pulmonary metastases had higher numbers of pulmonary nodules (mean of six vs. three nodules) and more frequent bilateral involvement than patients eligible for surgery (p-values respectively 0.002 and 0.06). Independent risk factors determining survival after metastasectomy in multivariate analysis were male sex (p=0.05), higher numbers of pulmonary nodules (p=0.03) and necrotic metastases (p=0.04). Patients undergoing repeated metastasectomies had a similar chance of survival as patients who underwent metastasectomy once.

This well-defined cohort of patients with extensive follow-up data enabled us to identify important risk factors determining survival in OS patients with pulmonary metastases. Risk factors determining poor survival after pulmonary metastasectomy were male sex, higher numbers of pulmonary nodules and resection of vital metastases. Furthermore, we demonstrate that even after repeated metastasectomies, curation can be achieved.


M.A. Gafur-Ahunov T.K. Mustafaev M.S. Gildieva F.E. Khayitov N.M. Karimova

It has been determined the prognostic importance of P-53 suppressor in 26 patients with osteogenous sarcoma of long tubular bones of lower extremities. Tumour localized in femoral bone in 14 observations (53,9%), in shin bone-11 (42,2%) and in fibular bone-1 (3,9%).

According to methods of treatment, all patients were divided into two groups:

I group: 18 patients received chemical and beam therapy. Treatment in this group was carried out by following scheme: intraneous metrotrexat, 25 mg/kg for 24 hours with leucovorin, intraneous cisplatin, 100 mg/m2 for 4 hours. OOD-2,2Gy, SOD 60Gy beam therapy (telegammatherapy) was conducted after 4 courses of chemotherapy, 5 courses of chemotherapy by above-mentioned scheme was made after the end of beam therapy course.

II group: 8 patients received chemo-beam therapy + operation + chemotherapy by scheme: intraneous doxorubicine, 60 mg/m2 for 48 hours, cisplatin, 100 mg/m2 for 4 hours on the 3 day, 4 courses with the interval of 3 weeks. After 4 courses of chemotherapy ROD − 2,2Gy, SOD 60Gy beam therapy was made. Subsequently after operation 5 patients received 5 courses of adjuvant chemotherapy.

Of 26 patients in 2 (7,8%) was noted complete effect, in 16 (61,5%) – partially effect, in 2 (7,8%) – stabilization of the process and in 6 (22,9%) – tumour progressing.

To estimate study results and determination of medicamental resistance of sarcoma there studied the rates of P-53 suppressor, as study results showed, in 6 (23%) observed moderate or high P-53 suppressor expression in tumor cells, and in 20 (77%) cases did negative and low-positive tumor or low negative and immunohistochemical tumor response. There established that low rates of P-53 suppressor correlated with high sensitivity of tumor to chemo-beam therapy, otherwise there obtained reverse reaction.

Conclusions: study results showed that P-53 suppressor rates have a significant importance in the determination of treatment strategy, tumor sensitivity to chemo-beam therapy and clinical outcome.


H. Matyusupov L. Koren M. Gafur-Ahunov R. Alimov A. Ososkov M. Ismailova

The aim of the research was to improve the results of complex ray diagnostics and monitoring in the treatment stages of patients with malignant neoplasms of soft tissues and bones using ultrasound dopplerography (US-dopplerography).

US-dopplerography data in 38 patients with tumors of soft tissues and bone tumors with infiltrated soft tissues are studied in the course of treatment. The following criteria were investigated by dopplerography: arterio-venous blood-flow, venous blood-flow, maximal velocity (Vmax) of blood, minimal velocity (Vmin) of blood, index of resistance (IR), pulse index (PI).

In 7of 38 patients US-dopplerography was performed repeatedly in dynamics. In 2 patients with fibrosarcoma character of neoplasm tissue blood-flow changed: in 1 patient after combined chemo- and ray-therapy neoplasm tissue blood-flow was not registered practically, in the 2nd patient indices of blood-flow decreased after chemotherapy. In 8 patients presented with fibrosarcoma blood-flow was not detected in the structure of neoplasm, and in 3 patients with the same diagnosis moderate peripheral blood-flow in the neoplasm was revealed. In one patient with osteosarcoma parameters of blood-flow in soft tissues infiltration were not changed even after 4 courses of chemotherapy. In the second patient parameters of blood-flow increased after 1st course of chemotherapy treatment, and after 3rd course blood-flow in the damaged area practically could not be detected. In 2 patients, presented with neuroblastoma and Khodjkin’s lymphoma, parameters of blood-flow decreased until complete disappearance after 2 courses of chemotherapy. In one patient with rhabdomyosarcoma blood-flow indices did not actually change in the process of treatment.

Parameters of US-dopplerography in dynamic control can serve as an indicator in the treatment efficacy assessment in patients with soft tissue and bone tumors.


R. Windsor S. Strauss B. Seddon M. Michelagnoli R. Labrum N. Wood J. Whelan

Osteosarcoma is the most common malignant bone tumour in children and young people. Approximately 40% patients respond poorly to highly toxic preoperative MAP (methotrexate adriamycin, cisplatin) chemotherapy with consequent inferior survival. The role of genetic polymorphisms in drug response and toxicity is reported in acute leukaemia and some solid tumours. Recent evidence in osteosarcoma suggests increased chemotherapy toxicity is associated with improved survival. The aim of this pilot study is to investigate the influence of drug target and metabolising gene polymorphisms on tumour response and chemotherapy toxicity in osteosarcoma.

Patients who have completed MAP chemotherapy are eligible. Chemotherapy toxicity (CTCAE grade) is collected from patient records. Tumour response is graded as good (> 90% necrosis) or poor (< 90% necrosis) in resection specimen. Peripheral blood DNA is typed for genome-wide single nucleotide polymorphisms (SNP) using the Illumina 610 Quad array and analysed using Bead Studio software. Standard PCR techniques are used to genotype the Thymidylate synthase (TS) gene (folate pathway) for the presence of 2 or 3 copies of a 28 base pair repeat (2R/3R) and a G/C SNP in the 3R allele.

52 patients have entered to date: 33 good responders, 12 poor and 7 unevaluable for response. Median age 18 years (range 10–51), males:females 1.3:1. Median follow up is 39 months (range 2–76) with 11 patients relapsing. 23 patients have TS genotype 2R/2R, nineteen 2R/3R, six 3R/3R, three 2R/4R and one 2R/7R. Neither TS repeat or G/C SNP genotype correlated with histological response or degree of methotrexate stomatitis. Interestingly, presence of the 2R allele was significantly related to relapse (p=0.01) but may reflect small patient numbers. Recurrent methotrexate stomatitis (> 2 episodes of CTCAE grade 2) was weakly correlated with no relapse (p=0.07). Analysis of SNP array data with emphasis on MAP pathway polymorphisms will be presented when complete.


S.D. Urunbayev M. A. Gafur - Akhunov Kh.G. Abdikarimov B.SH. Karahojaev R.R. Davletov

In 36 patients was carried out short-lived hyperglycemia and local hyperthermic prolonged intraarterial chemotherapy on the background of modificators of short-lived hyperglycemia in the department of general oncology of R. O.S. C of the H.M of the Republic of Uzbekistan. Tumour has localized in distal part of femoral bones in 18 patients, in proximal part of cannon bones in 13. Treatment was carried out by the scheme of Syclophosphan 1000 mg/m2 doxorubicin 90 mg/ m2 48-hourly unbroken infusion, cycplatin 100 mg2 in the dependence from efficacy of the treatment has been carried out from 1 to 4 courses In 3–4 hours time after beginning prolonged intraarterial chemotherapy unbrokenly began short-lived hyperglycemia by the way of introduction i/v solution of glucose 20% to1500ml. Maximal concentration of the blood sugar level has composed 18–23ml in the period of treatment. Then local hyperthermia with USD apparatus was carried out in 30MG frequency regime with exposition of 20 min. time. Control group of the patients has composed patients, who has performed system chemotherapy by analogical scheme CAP (in 34 patients). In the patients group, who received prolonged intraarterial chemotherapy with modificators (short-lived hyperglycemia with local hyperthermia) in 4 (11, 1%) patients have been observed full effect, in 25 patients (69, 4%) partial effect, in 5 (13,9%) stabilization, and in 2 (5,6%) progressing of tumour process. Safe operation was performed in 17 patients (47, 2%), crippling in 4 (11,4%) patients, conservative treatment in 15 patients (41,6%) in this group. In patients, who was carried out system chemotherapy full effect was marked in 2 (5,9%) patients, partial effect in 8 (23,5%), stabilization in 15 (44,1%) and progressing in 9 (26,5%) patients. Safe operations were carried out in 3 (8,8%), crippling operations in 19 (55,9%), other 12 (35,3%) patients are under observation after conducting 9 courses of chemotherapy and beam therapy without operation in conservative treatment.

Endovascular chemotherapy in combination with local hyperthermia and short – lived hyperglycemia allows overcoming medicinal steadiness and increases quantity of safe operations. That’s why combination prolonged intraarterial chemotherapy with modifications is aimed.


R. Schuch E. Korsching K. Agelopoulos B. Brandt K. H. Klempnauer H. Bürger

Tumorgenesis is often accompanied by transcriptional deregulation of oncogenes, such as the Epidermal Growth Factor Receptor (EGFR). Transcriptional activation of a gene requires the binding of transcription factors (TF) to regulatory DNA elements at specific transcription binding sites (TFBS). A better understanding of these interactions and regulation mechanisms is essential for the development of improved therapeutic applications.

ChIP was carried out to prove the existence of four new SP1 binding sites within intron 1 of the egfr gene. Site-directed Mutagenesis was performed on plasmids carrying the regulative sequence of the egfr gene in order to alter these binding sites. Activity of these sites and their influence on the transcriptional regulation were analysed by in vitro transcription and quantification using Ribonuclease Protection Assay (RPA) and qRT PCR.

Using ChIP, four novel SP1 binding sites could be confirmed to be active at the egfr gene intron 1 locus. Expression of the egfr gene was found to be highly dependent of these sites. Consequently, their mutation led to a 50% decrease of the transcriptional activity of the egfr gene.

The four new SP1 binding sites in the egfr intron 1 have a functional role in the egfr gene regulation, leading to a higher transcription rate. As so far only little is known about egfr gene activation, more TFs and TFBSs have to be analysed in order to gain a comprehensive understanding about the regulation of this important oncogene.


M.W. Karwacki W. Wozniak M. Rychlowska-Pruszynska I. Lugowsk

Tempting results of preliminary reports from EURAMOS-1 Study Group and our willingness to join the Consortium were the reason why we decided to start the pilot study exploit EURAMOS-1 protocol (approved by Local Ethical Commission).

Since November 2006, 41 patients were enrolled into study (20F/21M, mean age: 14, SD: 3,02) but 1 adolescent refused the treatment at all in 2nd week on. The main localization was thigh (20/41, 49%), followed by tibia (15/41, 37%), fibula (3/41, 7%) and humerus (3/41, 7%).

Majority of them had localized disease (27/41, 66%), whereas in 34% (14/41) lung metastases (LM) were revealed at diagnosis. Out of 40, 35 underwent surgery (2 amputations, 33 endoprosthesis) in 11th protocol week as average (mean: 12, SD: 2.80). Among the remaining 5 children, 4 progressed yet during neo-adjuvant CHT and 1 had to finish because of MTX intolerance. Up to now HP examination were completed in 29 children and the median of 12% of viable tumor cells remains (mean: 13%, SD: 22.32%; min. < 1%, max. 90%). Fourteen (48%) good responders continued on MAP arm. Children in whom poor HP response has been confirmed as well as all children with LM, received chemotherapy according to MAPIE arm. The switch between MAP and MAPIE proceeded in 18th week of protocol in average (median: 17th; nim. 14th, max. 24th week). Up to date, in 5 out of 21 patients completed the protocol, the treatment had to be finished untimely because of toxicity and further 5 required CHT switch because of progression.

Comparing achieved HP responses with previous experiences, we found no statistically significant differences in rate of tumor necrosis in current study (48%) as in previously used regimens (EORTC 49% and SFOP 44%; OR{EURAMOS/EORTC}=0.96; OR {EURAMOS/SFOP}=1.17; chi-square=0.343, p=0.842), but the general remarks from the pilot justify study’s continuation.


S. Pirson U. Thiel H. Bernhard G.H.S. Richter Stefan Burdach

The rationale of adoptive T cell therapy is based on the attempt to circumvent pre-existing tolerance mechanisms by stimulating potentially tumor-reactive T cells ex vivo. Efforts to eradicate cancer by adoptive T cell transfer have been limited due to the difficulty of isolating tumor-reactive T cells present in low numbers in peripheral blood of tumor patients. Furthermore, the development of an effective immunotherapy in the autologous context is hampered by the deficit of an effective T cell repertoire against tumor antigens.

We have optimized the techniques for isolating and expanding antigen-specific allogeneic T cells. Following repetitive peptide-driven stimulations with HLA-A*0201 positive dendritic cells the responding HLA-A*0201 negative CD8+ T cells were stained with HLA-A*0201/peptide pentamers. Multimer-positive T cells were sorted and directly cloned by limiting dilution. Using this technique we have succeeded in establishing T cell clones directed against several HLA-A*0201-resticted peptides derived from Ewing Tumor (ET) specific antigens identified via previous DNA microarray analysis and supposed to play a central role in the pathogenesis of this tumor. These T cells not only specifically recognized peptide-pulsed target cells or antigen transfected cells in the context of HLA-A*0201 but also killed HLA-A*0201+ ET expressing the antigen while HLA-A*0201– ET were not affected.

Allogeneic, tumor specific T cells can be easily isolated via Peptide/HLA-multimer technology and may benefit therapeutic strategies in allogeneic stem cell transplantation.


C. Dierkes B. Dierkes O. Wuesten H. Stuerz A. Schulz

Intracortical osteosarcoma is a comparatively rare and distinct tumor separated from conventional osteosarcoma and other osteosarcoma variants. At first, the lesion was described in two patients by Jaffe in 1960. To date, 17 cases have been described in the literature. In all cases, the tumor occured in the cortex of the shaft of the femur or tibia. En-bloc resection was performed as primary therapeutic approach in most cases, sometimes in combination with neoadjuvant or adjuvant chemotherapy.

We, for the first time, describe a case of intracortical osteosarcoma of the midshaft of the right ulna which was found accidentaly in a patient taking part in a screening programm for heriditary breast cancer.

The patient underwent en-bloc resection without additional chemotherpapy and shows no reccurence after 18-months follow up.


E.E. Pakos R.J. Grimer S.R. Carter R.M. Tillman A. Abudu L. Jeys D. Peake D. Spooner V.P. Sumathi L-G. Kindblom

Of 3000 patients diagnosed with primary malignant bone tumours and treated at our unit over the past 25 years, 234 (7.8%) were considered to be spindle cell sarcomas of bone (ie not osteosarcoma, chondrosarcoma, Ewing’s, chordoma or adamantinoma). We have analyzed their management and outcomes.

The diagnosis of these cases varied with fluctuations in the popularity of conditions such as MFH, fibrosarcoma and leiomyosarcoma with the passage of time. Treatment was with chemotherapy and surgery whenever possible. 36 patients had metastases at diagnosis and 17 had palliative treatment only because of age or infirmity. The most common site was the femur followed by the tibia, pelvis and humerus. The mean age was 45 and the mean tumour size 10.2cm at diagnosis. 25% of patients presented with a pathological fracture. Chemotherapy was used in 70% of patients the most common regime being cisplatin and doxorubicin. 35% of patients having neoadjuvant chemotherapy had a good (> 90% necrosis) response. The amputation rate was 22% and was higher in patients presenting with a fracture and in older patients not having chemotherapy.

With a mean follow up of 8 years the overall survival was 64% at 5 yrs and 58% at 10 yrs. Adverse prognostic factors included the need for amputation, older age and poor response to chemotherapy as well as a pathological fracture at presentation. The few patients with angiosarcoma fared badly but there was no difference in outcomes between patients with other diagnoses.

We conclude that patients with spindle cell sarcomas should be treated similarly to patients with osteosarcoma and can expect comparable outcomes. The histological diagnosis does not appear to predict behaviour.


K. Szuhai M. IJszenga D. de Jong A. Karseladze H.J. Tanke P.C.W. Hogendoorn

Ewing sarcoma (ES) is an aggressive sarcoma, and is the second most common bone sarcoma in childhood. Disease specific t(11;22)(~85–90%), t(21;22)(~5–10%), or rarer variant translocations with the involvement of chromosome 22 (~5%) are present. At the gene level, the EWSR1 gene fuses with FLI1, ERG or other ETS transcription factor family members. So far, no ES has been identified with a fusion to transcription factors other than ETS.

By using a panel of molecular tools such as multicolor FISH and array-CGH, a ring chromosome containing chromosomes 20 and 22 was identified in four ES cases. Molecular karyotyping showed the translocation and amplification of regions of chromosomes 20q13 and 22q12. Cloning of the breakpoint showed an in-frame fusion between the EWSR1 and NFATc2 genes. The translocation led to the loss of the N-terminal, calcineurin-dependent control region. Consequently, the remaining intact DNA binding domain of NFATc2 is under control of the EWSR1 promoter region permitting oncogenic activation. Intriguingly, in all cases a distinct histological feature was observed.

In conclusion: a new translocation involving EWS and NFATc2 was cloned that is associated with a histological variant of ES. The NFATc2 transcription factor is not a member of the ETS family of transcription factors. NFTAC2 has well characterized functions in T-cell differentiation and immune response. For the first time a direct involvement of NFATc2 in oncogenesis has been shown.


M. Lehnhardt A. Daigeler HH. Homann V. Schwaiberger O. Goertz HU. Steinau

Undifferentiated pleomorphic sarcoma/NOS (former pleomorphic and storiform MFH) of the extremities is a common malignant soft tissue tumor in adults. The objective of this study is to determine prognostic factors for the outcome after surgical treatment with respect to the recent developments in classification. From 1996 to 2004, 140 undifferentiated pleomorphic sarcomas/NOS were identified out of 1200 soft tissue sarcomas of the extremities that were treated at our institution and recorded in a prospective database. Overall survival (OS) and isolated local recurrence (ILR) were determined by Kaplan-Meier analysis. All tumors were retrospectively analyzed regarding prognostic factors of the disease, including patient’s background (primary or recurrent), histological grade (G2/G3), adjuvant chemotherapy and radiotherapy, size (T1-2) and depth of the tumor, and surgical margins (R0, R1, R2).

In 123 patients, a wide resection was performed (limb sparing surgery). In 9 patients, an amputation was necessary. The overall 5-year survival rate was 72% (median follow-up: 52 months). There was a significant difference between the group presenting with primary tumors (5y survival: 84%, p< 0.05) and recurrent tumors (5y survival: 62%, p< 0.05). Isolated local recurrence occurred in 36 patients.

In terms of OS and ILR, primary or recurrence, negative surgical margins, size and grading had a highly significant influence, whereas the site of surgery and adjuvant chemotherapy, adjuvant radiation and tumor depth did not. Prognosis for patients with undifferentiated pleomorphic sarcoma of the extremities depends predominantly on adequate wide resection of the primary tumor.


G.H.S. Richter S. Plehm A. Fasan S. Rössler R. Unland L. Quintanilla-Martinez M. Hotfilder M.S. Staege C. Müller-Tidow S. Burdach

Ewing Tumors (ET) are highly malignant, localized in bone or soft tissue and are molecularly defined by ews/ets translocations. DNA microarray analysis revealed a relationship of ET to both endothelium and fetal neural crest. We identified expression of histone methyl-transferase Enhancer of Zeste, Drosophila, Homolog 2 (EZH2) to be increased in ET. EZH2’s suppressive activity maintains stemness in normal and malignant cells.

Here, we found EWS/FLI1 bound to the EZH2 promoter in vivo and induced EZH2 expression in ET and mesenchymal stem cells. Down-regulation of EZH2 by RNA interference in ET suppressed oncogenic transformation by inhibiting clonogenicity in vitro. Similarly, tumor development and metastasis was suppressed in immunodeficient Rag2−/−γC−/− mice. EZH2-mediated gene silencing was shown to be dependent on histone deacetylase (HDAC) activity. Subsequent microarray analysis of EZH2 knock down, HDAC-inhibitor treatment and confirmation in independent assays revealed an undifferentiated phenotype maintained by EZH2 in ET. EZH2 regulated stemness genes such as nerve growth factor receptor (NGFR) as well as genes involved in neuroectodermal and endothelial differentiation (EMP1, EPHB2, GFAP, GAP43).

These data suggest that EZH2 might play a central role in Ewing Tumor pathology by shaping the oncogenicity and stem cell phenotype of this tumor.


A.T. Amiraslanov E.E. Ibragimov S.V. Abdiyeva

Aim of the research: generalization and optimization of methods of treatment of patient’s with fibrohistiocytic tumor of soft tissues.

Materials and methods: There were 79 (100%) patients under observation with malignant fibrohistiocytic tumor of soft tissue in the period from 2000 to 2006 year. There were 41 (51,9%) male and 38 (48,1%) female patients. The average age of patients were 45,5. Depending on localization of tumor on the lower extremities 47 (59,4%), on the upper extremities 19 (24%), trunk 13 (16,5%) of patients. Depending on histological structure of tumor the patients were distributed in the following way: 69 (87,3%) malignant fibrous histiocytoma, 10 (12,6%) atypical fibroxanthoma. In 49 (6,2%) cases were the initial tumor, at 30 (37%) were relapse tumor. In diagnostic used complex methods with including into investigation rentgenography, echography, USM, KT and MRT and morphological methods of research. The main methods of treatment are surgical, combine and complex. In initial and localized processes (the size of tumor < 5 cm) the main method is surgical (wide carving of tumor). The additional treatments to these patients did not make and they released under dynamic control. In our case there were 24 (30,4%) such kind of patients. In size of tumor from 5 to 10cm, and also in relapse at 17 (21,5%) patients on the first stage made surgical intervention, and then got distance gamma therapy (SOD 50Gy). In postoperative period conducted chemotherapy to 6 (7,5%) patients. In size of tumor more than 10cm in localization in upper extremities and trunk at 5(6,3%) patients the treatment begins with RT, and then surgical intervention +PXT by diagram CAPO, MAID, CAV II and others. In localization on lower extremities at 3 (3,8%) patients treatment begins with intra-arterial infusion Doxorubicin hydrochloride in 30mg/m2 during for 3 days (90mg/m2) and then surgical intervention +RT 50 Gy. At 18 (22,8%) patients were carving relapse, at 9 (11,5%) amputation, at 4 (5,1%) patients were exarticulation.


A. Parafioriti S. Del Bianco E. Armiraglio P.A. Daolio S. Mapelli

Ewing sarcoma is a malignant bone tumour characterized, in 90% of the cases, by the balanced chromosomal translocation t(11;22) which generates a chimeric oncogene that acts as a transcriptional activator. The detection of translocation can be fundamental in cases with an extraosseous or unusual location which are histologically difficult to diagnose and it is also helpful in evaluation of residual disease. We joined immunohistochemical analysis and routine RT-PCR method together, the latter one allowing the detection of the most common fusion transcript EWS-FLI1 in archival paraffine-embedded tissues of EFT patients. We used a pair of primers which allowed us to discriminate between two subtypes of EWS-FLI1 transcript. We selected some sample for EWS-FLI1 typing using a Real-Time PCR assay.

We analysed 54 EFT patients. RNA was extracted from paraffine-embedded sections and reverse transcribed into cDNA. On every sample we performed RT-PCR and immunohistochemistry for the marker CD99; we also selected 5 samples for Real-Time PCR analysis.

Fourty-nine out of 54 samples had a RNA suitable for analysis. Thirty-six patients had EWS-FLI1 type I fusion transcript while 6 patients EWS-FLI1 type II; in 7 samples we couldn’t find any fusion transcript although their RNA was good. We tested 5 of these negative samples with Real-Time PCR and we found 2 patients who were carriers of EWS-FLI1 type I fusion transcript. CD99 resulted positive in 34 samples out of 54.

The detection of fusion transcripts using RT-PCR methods can be useful as a support to EFT diagnosis. Moreover the possibility to assess a Real-Time PCR assay enhances analysis sensibility and minimizes the chance of false positives. EFT cytogenetic characterization completes morphologic and immunophenotipic data allowing a more careful classification and an identification of subgroups with different prognosis.


J. Rentschler H.C. Rischke M. Caballero

Palliative therapy of Malignant Fibrous Histiocytoma (MFH) is mainly based on conventional chemotherapy using anthracyclines and ifosfamide. Intervals between therapies allow abundant recovery of tumour vasculature. An unspecific antiangiogenic effect of chemotherapy can be induced by continuously administering low doses of drug referred to as Metronomic Chemotherapy (MCT). MCT may be combined with specific VEGF targeting drugs in order to increase the antiangiogenic impact on the tumour.

We report on a 57 y.o. male patient with heavily pre-treated advanced stage MFH. Previous polychemotherapies consisted of 8 cycles EIA in adjuvant setting in 2002, 4 cycles ICE in recurrent situation in 2003 and 6 cycles of Dacarbacine plus Epirubicine in 2006. In 2005 and 2006 radiation therapy of paravertebral tumour lesions was done. In September 2006 the patient was admitted to our hospital with multilocular metastatic progressive disease. Performance status was WHO1. A moderate asymptomatic anthracycline induced cardiomyopathy was detected. The cumulative dosage threshold for anthracyclines had been exceeded before. We initiated oral MCT with Trofosfamide 150 mg pd plus iv. – antiangiogenic therapy with Bevacizumab 5 mg/kg q 2w. Follow up (FU) was done via F18-PET-CT.

First FU after 8 weeks of combined therapy showed metabolic partial remission (PR) (48% decrease in mean Maximum Standard Uptake Valule (SUVmax) of target lesions) and metric stable disease (SD) (5% decrease in sum of diameters according to RECIST criteria). Trofosfamide was tolerated well. Treatment with Bevacizumab had to be stopped after 8 weeks because of symptomatic deterioration of cardiomyopathy (Ejection Fraction now 25%). Trofosfamide was continued as monotherapy. After 8 weeks of Trofosfamide alone PET-CT showed one new lesion indicating progressive disease according to RECIST but persistent metabolic remission of all pre-existing lesions. Bevacizumab then was added again but couldn’t stop further tumour progression (FU in March 2007). In summary disease control was achieved for 4 months. Combined metronomic and antiangiogenic therapy led to disease stabilisation and even metabolic remission measured by F18-PET-CT in a heavily pre-treated patient with soft tissue sarcoma. A pre-existing anthracycline-induced cardiomyopathy deteriorated under treatment with Bevacizumab. Whether response duration could have been prolonged by administering Bevacizumab without interruption remains speculative. The role of PET-CT in early detection of response is still to be determined.


M. Massada A. Pereira J. Sousa D. Freitas P. Cardoso

Synovial cell sarcoma is one of the most common soft tissue tumours. Prognosis of this tumour is related to initial care. Survival rates have improved in the past 20 years because of treatment with primary radical surgery, along with chemotherapy and radiation.

This case report is about a woman, of 68 years old, with a left shoulder-related pain and mass with about four months. The image study showed a lobulated and irregular mass, with about 12x10x9cm, infiltrating the rotator cuff and glenohumeral joint. The core needle biopsy confirmed the presence of a synovial sarcoma, staged as a T2N0M0.

The treatment started with neo-adjuvant chemotherapy, with a poor response. Then, surgery was performed, with a wide excision of the scapula, proximal humerus and clavicle (type IV of Malawer) without reconstruction. The treatment regime ended with the radiotherapy. Eighteen months after the surgery the patient remains disease-free and a neo-joint is starting to form. At this time the DASH score was 63.8. Despite the flail shoulder function is acceptable.

Conclusion: In such an aggressive tumour, an extensive and multidisciplinary approach is imperative but always with regard to the limb function.


R. Jennings N.D. Riley B. Rose R. Rossi A. Saifuddin J.A. Skinner S.R. Cannon T.W.R. Briggs R. Pollock

Chondrosarcoma is the second most common primary malignant bone tumour. Distinguishing between grades is not necessarily straightforward and may alter the management of the disease. We evaluated the correlation between the pre-operative needle biopsy and excision biopsy histological grading of chondrosarcoma of the femur, tibia and humerus.

A consecutive retrospective series of 100 patients with a histological diagnosis of chondrosarcoma was reviewed. Twenty-one patients were excluded because 20 had only excision biopsy and one had only the pre-operative biopsy on record, thus this series included 79 available cases. In 11 instances, there was a discrepancy in histological grade.

Therefore, there was an 86% (68 out of 79) accuracy rate for pre-operative histological grading of chondrosarcoma, based on needle biopsy. However, the accuracy of the diagnostic biopsy to distinguish low-grade from high-grade was 90% (71 out of 79).


José Casanova João Freitas Pedro Carvalhais Marco Lucas João Corte Real Alexandre Marques Edgar Rebelo Pedro Serrano Emanuel Furtado Antònio Laranjo Helena Garcia Miguel Jacobetty e Paula Alves

Introduction: Soft tissue sarcomas (STS) are rare tumors. A multidisciplinary approach including surgery, chemotherapy and radiation therapy is recommended.

Materials and Methods: In the last 12 years, 249 patients with STS were teated in our Institution. All of them were treted with a multidisciplinary approach using all or some of the previous refered treatments.

Results: The overall local recurrence rate in the group of patients submited to surgery was 25% and this factor was related mostly with contaminated margins. Surgical resections were associted with soft tissue reconstructions when needed.

Radiation therapy was used in both regimens pre and post operativly, chemotherapy was also used in 85% of the patients, and was not dependent of tumor histotype.

23 patients were submited to surgery of lung metastasis.

Survival rates were determined and compared with stage (AJCC), tumor histotype and surgical margins.

Conclusions: Multidisciplinary approach is the recommended treatment for STS.


MAJ van de Sande P.D.S. Dijkstra J.V.M.G Bovee A.H.M. Taminiau

Synovial sarcoma (SS) is rare but increasingly diagnosed and associated with poor prognosis. Primary surgical resection with wide margins and adjuvant radiation-therapy is considered gold standard in treatment of primary SS. Although (Neo)adjuvant chemo- and radiationtherapy are used in the primary treatment of SS, they are not advocated outside a clinical trial setting. In patients with primary SS and pulmonary metastases, (neo)adjuvant chemotherapy is often added to the treatment protocol but it’s effect on overall survival seems limited.

Between 1985 and 2004 33 patients with primary SS were treated in our clinic. Seventeen patients were diagnosed with pulmonary metastases at presentation (9) or during postoperative follow-up (8). Wide resection or focally marginal resection followed by radiotherapy was used as primary treatment for all patients. All primary metastasized patients were treated with adjuvant multi-agent chemotherapy including Isofosfamide. Average survival in this group was 32 months (5 year OS 50%), compared to 60 months in the late metastasized patient-group (2 and 5 year OS 50 and 11%). Wide resection was not related to improved overall survival when compared to marginal margins and additional radiation therapy. In the early metastasized group combined chemo-radiaton therapy provided no significant improvement in overall survival over adjuvant chemotherapy or radiation therapy alone. However additional chemotherapy in the late metastasized group was slightly associated with increased overall survival (5 year OS 0% vs 66%).

Treatment of early pulmonary metastasized SS remains highly dependent of the individual preference of patient and physician. In contrast to the reported prolonged disease free/overall survival of Enneking stage IIA and IIB SS patients, aggressive surgical and chemo-radiation therapy has not yet been associated with improvement of disease free/overall survival in stage III disease. Patients presenting with late pulmonary metastasis might benefit from adjuvant multi-agent chemotherapy treatment.


A. Pereira M. Massada J. Sousa R. Sousa D. Freitas R. Claro P. Cardoso

Chondrosarcoma is the second most frequent primary malignant tumour of bone, representing approximately 25% of all primary osseous neoplasms. Chondrosarcomas are a group of tumours with highly diverse features and behavior patterns, ranging from slow-growing non-metastasizing lesions to highly aggressive metastasizing sarcomas. As radio and quimio-resistant tumours, the surgery constitutes the unique chance of cure. Nowadays, besides the curative intention, the reconstructive surgery is also a priority in order to save the limb and optimize the function.

This case report is about a young woman, of 24 years old, with hip-related pain and a large mass in the left pelvis. The imagiologic study showed a large mass of about 8 cm of large diameter, starting at the anterior wall of the acetabulum, involving the pubic arcs and with matrix calcification. The core needle biopsy confirmed the presence of a chondrosarcoma, staged as a IIB of Enneking.

Because of its size and localization the limb salvage surgery has been a challenge. The surgery included a broad approach of the left hemipelvis, with wide excision of the tumour, reconstruction of the abdominal wall with a propylene prothesis and reconstruction of the hemipelvis with a “custom-made” prothesis with preservation of the femoral neurovascular bundle. The patient started to walk with total bearing after three months and had a normal gait and a nearly normal life during eleven months. Fifteen months after the surgery lung metastasis and local recurrence were diagnosed and she died six months after.

Conclusion: The surgery is our unique weapon in the “combat” against the chondrosarcoma. The reconstructive surgery must be a concern to give to our patients the best functional result and quality of life.


T. Budny C. August M. Balke A. Streitbürger R. Dieckmann H. Ahrens M. Henrichs N. Alt G. Gosheger J. Hardes

Chondrosarcoma are rare malignant tumors. About the biological characteristics of chondrosarcoma is little-known [2]. Endothelin and its receptors are involved in regulating angiogenesis and metastatic dissemination [1]. The aim of this study is first to identify if chondrosarcoma are expressing endothelin-1 (ET-1) and the endothelin-receptors and thereupon to identify potential molecular markers for new target therapies. Another aim is to determine if endothelin is a prognostic factor in chondrosarcoma.

32 cases were investigated clinically and histopathologically. The expression of vascular endothelial growth factor (VEGF), Endothelin-1, Endothelin-Receptor-A (ETR-A) and Endothelin-Receptor-B (ETR-B) were determined. All data were analyzed by Fisher’s exact test (p< 0,05). All tumors show an expression of either ET-1, ETR-A or ETR-B. Chondrosarcomas with grade (G) I are mostly expressing less than 10-% ET-1 in cells, Chondrosarcomas G II are expressing in most cases between 10–50% and nearly all Chondrosarcoms G III more than 50%. In addition ET-1-expression is correlating with the histological grading. The patients also show a significant high metastatic dissemination probability at the time when tumor samples present more than 10%-storing ET-1-cells. The intensity of ET-1-expression is correlating with VEGF, which is the most important angiogenetic factor in tumors.

Chondrosarcomas are expressing ET-1, ETR-A and ETR-B. ET-1 seems to play a role in the angiogenesis of chondrosarcoma. Increased expression of ET-1 is accompanied with a high probability of metastatic dissemination. Endothelin receptor antagonists, which are used for example in prostate and breast cancer, can represent a potential therapy for chondrosarcoma [1]. Experiments on animals and clinical studies are required.


Y.M. Schrage I. Machado I. Briaire-de Bruin B.E. van den Akker A.H.M. Taminiau T. Kalinski A. Llombart-Bosch J.V.M.G. Bovée

In both Enchondromatosis (EC) and Multiple Osteochondromas (MO), multiple benign cartilaginous tumours occur, which have a severely increased risk of malignant progression. Preventing new tumor formation and malignant progression would benefit the prognosis of these patients. A protective effect of selective Cox-2 inhibitor celecoxib, has been suggested against development and growth of colorectal cancer in familial syndromes. At last year’s EMSOS meeting we reported on expression of Cox-2 in 37% (central) – 46% (peripheral) of conventional chondrosarcomas. mRNA levels of EC related tumours were slightly higher than the solitary tumours. Celecoxib treatment of the chondrosarcoma cell lines resulted in a 3 fold decrease of PGE2 levels already at 5 μM. A significant decrease in proliferation was found at 10 μM in OUMS27 and at 25 μM in SW1353 and CH2879 compared to DMSO controls.

For the present study we assessed the (prophylactic) effect of celecoxib on chondrosarcoma growth in vivo using a xenograft model of immunoincompetent nude mice which were injected with cell line CH2879 subcutaneously. Tumour volume was measured during 8 weeks. Celecoxib serum levels were determined by HPLC. Expression of proliferation marker Ki-67 and Cox-2 was assessed by IHC.

Our in vivo results also showed a beneficial effect of high dose prophylactic celecoxib treatment. Tumour volumes were negatively correlated with celecoxib serum levels (r2=0.152). However, at the end of pubertal growth of the mice, a catch-up tumour growth was observed, resulting in the absence of differences in tumour volume between control and treatment groups. Accordingly, proliferation marker Ki67 was higher expressed in the treated groups at sacrifice.

This suggests that there is no role for celecoxib in the treatment of adult chondrosarcoma patients. Celecoxib treatment of younger patients, especially to prevent formation of new tumours in EC and OC patients, might be beneficial, however more research is necessary.


G. Moriceau B. Ory L. Mitrofan C. Charrier R. Brion P. Pilet L.D. Shultz J. Mönkkönen F. Rédini D. Heymann

Osteosarcoma is the most frequent malignant primary bone tumors. Despite recent improvements in multimodal therapy the problem of non-response to mono-chemotherapy remains. Therefore, novel multi-drug combinations targeting various molecular pathways are needed to decrease the emergence of resistance phenomenon and to potentiate the treatment efficacy. In this context, the effects of RAD001, a new orally available mTOR inhibitor was investigated in vitro and in vivo on osteosarcoma proliferation, both alone and in combination with Zoledronic acid (ZOL). The in vitro effects of ZOL and RAD001 were analyzed on human (MG63), rat (OSRGa) and mouse (POS-1 and MOS-J) osteosarcoma cell lines in terms of cell proliferation (XTT assay, manual cell counting, time-lapse microscopy), cell cycle analysis (flow cytometry analysis) and apoptosis (caspase 1, 3 and 8 activity). RAD001 and ZOL inhibit MG63, OSRGA and POS-1 osteosarcoma cell proliferation in a dose- and time-dependent manner without any modification of cell cycle distribution. In contrast, MOS-J cells are resistant to ZOL and RAD001. In all cell lines assessed, combination of RAD001 and ZOL exerts synergistic effect on the inhibition of cell proliferation and induces a significant decrease of P-mTOR, P-4EBP1 and Ras expression with no accumulation of IPP and ApppI. This drug combination has been then investigated in a mouse osteosarcoma model induced by i.m. inoculation of MOS-J cells in C57BL/6J mice. Clinical relevant doses of RAD001 (5 mg/kg) and ZOL (100 μg/kg) alone have no effect on tumor growth in contrast to combination of both drugs which decreases osteosarcoma progression. ZOL (alone or in combination) strongly increases bone formation. The combination of RAD001 with ZOL improves tissue repair as shown by important area of fibrosis into the residual tumor mass. The present work demonstrates the in vitro and in vivo synergistic effect of mTOR (RAD001) and mevalonate (ZOL) pathway inhibitors and suggests that ZOL potentiates RAD001 activity through Ras molecular pathway.


D.B. Hestanov A.V. Igoshin A.V. Shvarova N.M. Ivanova M.D. Aliev

The aim of the our study was to analyze prognostic factors characterizing biological behaviour of a tumour and specific features of the patient and to develop rational strategy of the combined treatment of chondrosarcoma (CHS) in children.

Between 1982 and 2008 seventy seven patients with CHS were observed and treated in our center. 38 (49,4%) were male and 39 (50,6%) were female. In all cases the diagnosis was confirmed by histological examination. In cases of high grade/mesenchymal or metastatic (into lungs) CHS we use polychemotherapy consist of alternating courses of CDDP, adriamicin, ifosfamide and etoposide and high-dose methotrexate (8–12 g/m2). Intensive polychemotherapy allow us to expand indications for limb salvage treatment. Using growing (conventional and non-invasive types) endoprostesis improved the quality of life. 5-years RFS was 75,4±7,8 % (Kaplan-Meier curves, p=0.02). The most significant prognostic factors were grade of histological response, morphological type of tumour and type of polychemotherapy (conventional or intensive)


N. Entz-Werlé T Lavaux D Modrowski C Lasthaus E Guérin L Brugières P Marec-Berard MD Tabone C Schmitt JC Gentet MP Gaub

Despite the recent progress, non-metastatic pediatric osteosarcomas have now a 5-year overall survival (OS) around 75% and the metastatic forms are decreasing to 20–30%. To increase these survival rates, new molecular approaches are on development to understand and highlight new candidates for targeted therapies. Tyrosine kinase receptors (TKR) are one of this target class, where new drugs were especially developped, screening now a large spectrum of TKR. After the demonstration among cancers of TKR’s clinical utility as surrogate markers to guide the selection of patients susceptible to respond to these treatments, this success was recently tempered in part because of cancers developping resistance mechanisms to these drugs. A study was conducted to evaluate the interest of these molecular targets among pediatric osteosarcomas.

Materiel and methods: 91 pediatric patients treated homogeneously with the French OS94 protocol were included in this analysis. Allelotyping, real-time quantitative PCR (QPCR), sequencing and immunhistochemistry were performed to analyse the following targets: EGFR, MET, PDGFRA, KIT and ERBB2.

Results and discussion: Most of these targets were rearranged in more than 45% of the population and mainly deleted. Only 11.4% were amplified at MET and 8.6% at PDGFRA. By QPCR, ERBB2 was normal in 78 out of 81 informative patients. Surprinsingly, wild-type KIT protein was amplified in 37%. EGFR was rearranged by allelotyping in 48% and QPCR evaluation just started. MET amplified subgroup is linked to a worst OS than normal and deleted subgroups (p=0.04) whereas PDGFRA amplified tumors tend to be significantly linked to a better patient OS (p=0.08). Considering all amplified subgroups, no ovelap was found as if an osteosarcoma could only be amplified for one gene. This observation could be considered as a way to increase the potential targeted populations where the use of large spectrum TKR inhibitors would be useful in osteosarcoma treatment.


J. Smida M. Rosemann M. J. Atkinson A. Walch M. Nathrath

Despite significant improvements of survival in patients with localized osteosarcoma, about 30–40% of the patients still die on tumor progression or relapse. In order to improve therapeutic outcome we postulate the need for individualized intervention schemes based on biological characteristics of the tumor. Identification of molecular changes important for pathogenesis and tumor progression is complicated by the complex karyotype of the tumor with numerous structural and numerical alterations. Here we describe the use of Affymetrix single nucleotide polymorphism arrays in a genome wide high-resolution approach to assay both loss of heterozygosity and variations in DNA copy numbers in 46 osteosarcoma biopsy samples. We combined established histological response parameters with our genetic findings to predict prognosis.

We found that overall chromosomal changes in osteosarcoma are good predictors of response to chemotherapy and outcome. Analyzing the minimal recurrent regions harbouring chromosomal alterations we expanded our investigations towards identification of gains and losses of chromosomal material and found candidate genes as potential prognostic parameters and therapeutic targets. Identified genomic regions and genes were validated by mRNA-expression studies and correlated with proteom analysis by MALDI Imaging.

Thus, structural chromosomal alterations detected by SNP analysis may serve as a simple but robust parameter to predict response to chemotherapy. The results also indicate that we are able to identify several genomic loci with high potential to predict the outcome of the disease. Furthermore new potential target genes were identified by this genome wide screen.

The project is part of the Translational Sarcoma Research Network (TransSaRNet).


E. Korsching S. Liva E. Barillot A.M. Cleton-Jansen A. Neumann R. Schuch H. Bürger K. Agelopoulos

The concept of translational research is always hampered by the problem that most of the disease phenotypes do not have a mono causal origin. Therefore most treatment schemes based on one to three drugs are not really productive for most of the patients even if the patients are carefully selected from the responder group. Here the array techniques has inspired many research groups to develop algorithms deriving interaction networks or regulatory networks from this type of data to better get rid of the complexity of the biochemical interactions. The challenge is to find networks and to select the group of master nodes which might be good targets for a balanced multi-drug treatment. This means not only to measure one data type with array techniques but to join array data from multiple platforms and different data levels. Our goal is to integrate these data types to form networks with a predictive character for osteosarcomas.

The existing web platform CAPweb/VAMP from the Institute Curie is based on a Java web-client and R. This platform is focused on array data analysis and visualisation, can be extended by additional R modules and is therefore an excellent choice to implement further algorithms for data integration and network prediction. We are now establishing algorithms beyond a pure association of effects like permutation procedures for optimal rank orders of effects in a given subset of 16 factors which can be assembled to bigger units and selection procedures of gene expression signals by gene dosage concepts.

The presented approach is sustainable because the platform can be constantly extended and improved. On the other hand this platform is end-user suitable. This is the best way to bring theoretical concepts to the bench scientist. As a consequence translational research will become more real and complex systems more feasible.


M. Gafur-Akhunov M. Gildieva J. Polatova H. Abdikarimov

Background: to study the expression of Bcl-2 gene in osteogen sarcoma of long tubular bones and their effect on the disease prognosis.

Study was conducted in 20 patients with osteogen sarcoma of long tubular bones. Of 20 patients studied in 11 patients tumor was localized in femoral bone, in 6 patients in tibia and in 3 patients in fibula. Slices taken from the tumor in open biopsy were the object of research. Immune-hystochemical research was carried out by the standard technique applying antibodies to Bcl-2. The assessment response was made by visual simiquantity method: expression absence was-0, weak-1 (+), moderately expressed-2 (++), intensive-3 (+++). 17 patients were given chemoradiotherapy, 3 patients combined treatment (surgical + adjuvant chemotherapy). 12 got intraarterial chemotherapy (72 hours) by CAP regimen (Cyclophosphamide, Adriamycin, Cisplatin) – 4 cycles with three week interval. Then telegammatherapy, single dose 3.5 Gy up to general dose 60–70 Gy was made, later chemotherapy was completed up to 9 cycles at the same regimen. 8 patients were carried out 4 cycles of intra-arterial chemotherapy by MP regimen (Methotrexate, Cisplatin) with three week interval. Radiotherapy used subsequently (General dose 60–70 Gy) and chemotherapy was reached up to 9 cycles at the same regimen.

Research has shown, that in the most of patients 13/20 (65 %) had moderately positive and low positive expression of Bcl-2 gene, in 4/20 (20 %) cases reaction was negative and in 3/20 (15 %) cases it was the expression of the given gene that was high. The assessment of treatment efficiency was carried out by WHO recommendation. The whole effect was obtained in 6 patients (30 %), partial in 11 (55 %) and progressing was in 3 (15 %). Most patients who were given the treatment by specific scheme: chemotherapy + radiotherapy + chemotherapy had good parameters in life expectancy, where 6 of 8 patients (75 %) lived without relapse and metastases more than one year. All patients (3) had numerous lung metastases in operation + chemotherapy group of patients.

Aggressive current of tumoral process was characterized with high expression of Bcl-2 gene in tumor tissue. The level of expression Bcl-2 gene can testify the efficiency of conducted treatment.


M. González Gaitano N. Hernández de Leòn L. Coll Mesa J. Vega Sanginés P. Sánchez Hernández M. A. Ayala Rodrigo M. Porras Sánchez

Osteosarcoma shows a variety of histologic patterns. Uncommonly, this tumour has an epithelioid appearance, and the rosette formation is more rarely observed.

We report an unusual case of a 12 year-old girl who was referred to us with pain and a mass around her left shoulder with upper limb motor dysfunction. X-ray showed a pathologic fracture of the proximal humerus. Biopsy was performed. Histologically, the neoplasm is characterized by a small multinodular growth pattern. The tumoral cells have plasmocitoid or epithelioid shape and they are arranged forming rosettes. Sheet-like osteoid deposition was found. Inmunohistochemical studies revealed the tumour to be positive for epithelial membrane antigen (EMA), vimentine, CD-99 and neuron-specific enolasa (NSE).

The rosette-forming osteosarcoma has an aggressive clinical behaviour. The location, clinical features and chemotherapy effect are important prognostic factors. Histological differential diagnosis includes small cell osteosarcoma, metastatic neuroblastoma, PNET and metastatic carcinoma.


N. Entz-Werlé T Lavaux D. Guenot F Perrin-Schmitt MP Gaub

Dysregulation of differentiation genes involved in developmental signaling pathways seems to be a decisive event taking part in the multistep oncogenesis. As high grade osteosarcomas are histologically defined by the presence of malignant osteoblasts producing an osteoid component, we focused in a pediatric cohort, homogeneously treated with the French OS94 protocol, on the genomic status at diagnosis on tumor biopsies of several genes involved in flat and long bone formation.

Material and methods: In 91 pediatric osteosarcomas, allelotyping analysis of FGFRs, TWIST, DERMO1, APC, MET, HGF, and SDC2 was done. After DNA extraction of paired blood and tumor samples, each locus was analysed by microsatellites bordering closely on each side the targeted genes. Complementary real-time quantitative PCR of TWIST, FGFRs and MET genes and sequencing of APC and TWIST were performed to determine gene status.

Results: The allelotyping results support the frequent role of each gene: 53.1% of allelic imbalances (AI) were found in 7p21.2 (TWIST), 35.3% in 2q37.3 (DERMO1), 38% in 5q21 (APC), 42.5% in 7q31 (MET), 45.5% in 7q21.1 (HGF) and 49% for 8q22 (SDC2). TWIST and MET were mainly deleted and no additional APC and TWIST mutations were identified. Surprisingly, FGFR1 to 4 are only abnormal in small subgroups. Significant associations were found combining the presence of MET AI to HGF abnormalities and the presence of MET, TWIST and APC losses. A worse outcome was significantly linked to the presence of MET, TWIST and APC losses (p=0.05, 0.04 and 0.02, respectively) but the subgroup combining MET and HGF abnormalities seems to have a better survival. No correlations was done with other clinical data.

Conclusion: Several genes involved in normal bone development seem to have a role in osteosarcoma development but also to modulate the prognostic outcome of these pediatric patients.


Jelena Sopta Jelena Marinkovic Vesna Mijucic Zoran Vucunic Jelena Bokun Dusan Ristic Dejan Minic

Introduction: The prediction of clinical and biological behavior of bone tumors plays an important role in medical tasks such as diagnosis and treatment planning. Different prognostic factors for bone tumors outcome appear to be significant predictors for making definitive diagnosis. It is well-know that different clinical, radiological and histological characteristics are included in diagnostic process. The most important task for pathologist is to determinate biological behavior. Errors in diagnosis lead to wrong therapy and treatment.

It was reason to determinate scores for tumor diagnostics. Score is usually determinate using classic statistical methods such multivariate logistic regression (MVLR), but new computer tehniks, and models of artificial intelligence take a place in modern scoring systems. Recently, classifications tree analysis (CTA) and artificial neural network (ANN) models have become popular in decision-making and outcome prediction of clinical medicine, especially in oncology.

This study compared the levels of accuracy of MVLR, CTA and ANN model for the prediction of bone tumor’s biological behavior.

Material and method: Data from patient who had diagnosed bone tumors in Institute of pathology, School of Medicine in the period of 10 years (1995–2004) were used for analysis purposed in the study. In the analyzed date –base were 3689 biopsies with these criteria. About 24% (882 biopsies) were excluded because of missing data about radiological presentation. Consequently, data from 2807 biopsies were used for the analyses

Clinical, radiological, histological characteristics, summary 166 variables were analyzed and used to compare the levels of accuracy for the three methods of scoring.

All data were inserting in Spider 2.0 enterprise date-base who assisted MSSQL server 2000.

For MVLR and CTA we used SPSS 15.0 program with incorporate CTA. There are methods of multivariate analysis that allow for study of simultaneous influence of a series of independed variable on the one depended variable (biological behavior of bone tumors). The ANN model used in this study were feed-forward networks, witch were trained with a back propagation algorithm (NNSYSID-Neural Network Based System Identification Toolbox) situated in the Matlab area.

We compared three models across theirs overall percentages. The best model was one with highest overall percentage.

Results: From all analyzed cases 1590 (56, 6%) were males and 1217 (43, 4%) were females patients with Middle Ages 34, 1 (aged from 0–94 years). Malignant bone tumors (prime and metastatic lesions) were 1339 (47,7%) and benign 1468 (52,3%).

From all (166) characteristics 11 were selected on the bases of a definitive analysis and included into scoring system. From clinical characteristics just age of patient and clinical diagnosis “cyst” were included. Next radiological presentations: Pure osteolysis, osteolysis with cortical destruction, osteolysis with soft tissue mass, mixed lytic and sclerotic lesion was statistically significant for scoring model. Histological presents of fibroblasts, giant cells with hamosiderin pigment in stromal cells and atypical stromal cells, and hondroid stromal production were important for classification. Localization in finger’s bone was included in definitive score too.

Three performed scoring models showed wary high overall percentages in prediction biological behavior of bone tumors: MVLR 93, 77%, CTA 88, 2% and ANN 91, 5%. The most informative variable, rang 1 in both models of artificial intelligence was radiological criterion. For CTA it was radiological presents of lytic lesion with soft tissue mass and for ANN was combined lytic and sclerotic presentation.

Conclusions: All three scoring models are very useful in prediction bone’s tumor behavior, most of them each ones had priority versus others. The most successive (overall percentage 93, 77%) was MVLR. ANN had high sensitivity (overall percentage 93, 77%) and gave ranges of variables included in score. CTA algorithm had the least overall percentage but it is very simple and figurative for interpretation.


V. Derzhavin N. Marshutina M. Solohina V. Karpenko N. Sergeeva V. Teplyakov

The aim of the study was to examine TRAP-5b as serum tumor marker for patients with primary malignant bone tumors.

In total 69 patients were included in protocol: 34 – with primary malignant bone tumors – 1st group, 35 – with non-oncologic pathology of bone tissue (12 – with benign bone tumors and 23 – with traumatic bone fractures) – 2nd group and 38 healthy donors – 3rd group. The distribution of patients according age and sex in all groups was similar. The level of TRAP-5b was examined by means of immunoassay method.

The low value (< 3,0 U/L) of TRAP-5b was found in 39% cases in 2nd group, in 31% cases of donors in 3rd group and only in 3% cases of patients with malignant bone tumors. High concentrations of TRAP-5b (> 6,0 U/L) were found in serum of only one patient from 2nd group and only one donor. At the same time TRAP-5b level more than 6,0 U/L was determined in 35% cases of patients with malignancies. The average TRAP-5b value was: 6,14±0,51 U/L in 1st group, 3,9±0,18 U/L in 2nd and 3,7±0,27 U/L in 3rd group. The marker level was higher in group of patients with osteolytic component of bone destruction, compared with group of patients with mixed type of destruction (7,74±0,73 U/L vs. 4,48±0,92 U/L).


P.C. Jutte

Bone tumours around the foot are relatively rare. I composed a poster with a short history and some images on seven different tumours around the foot. The reader is asked to give the most likely diagnosis. The answers can be found hidden on the poster.

The aim is to enlarge the knowledge of the EMSOS participants on tumours around the foot.


RJ Grimer SR Carter RM Tillman A Abudu L Jeys

Aim: To estimate the risk of bone malignancy arising in premalignant conditions.

Methods: There are quite a number of possible premalignant conditions with considerable uncertainty about the actual risk of a bone sarcoma developing. The incidence of these malignant conditions was identified from a prospective database containing 3000 primary bone sarcomas.

Results: 178 of the 3000 patients with newly diagnosed bone sarcomas had a pre-exiting condition which in all probability led to the sarcoma. These included 50 with previous radiotherapy treatment and 47 with Paget’s disease. 31 patients developed malignancy in HME, 8 with neurofibromatosis and 7 each with Ollier’s disease and retinoblastoma. There were 4 malignancies in patients with Mafucci’s syndrome, 3 in patients with fibrous dysplasia, 3 in patients with synovial chondromatosis and 2 in patients with Rothmund-Thomson syndrome.

Given that the incidence of bone sarcomas is 9/million population per year, our 3000 patients represent 333 million population years. When the incidence of a condition is known in the population this allows an estimation of the risk of malignancy compared with the normal population. Retinoblastoma for instance is known to arise in 1 in 16000 births. The 7 malignancies we saw thus represents a risk to individuals with retinoblastoma of 336/million/yr – a figure 37 times the risk of the normal population. Approximate figures of risk have been calculated for other entities.

Conclusion: Data from a supra-regional register allows an approximate estimate of the increased risk of bone tumours in premalignant conditions.


H. Gelderblom J. Braun K.W. van Kralingen P.C.W. Hogendoorn F.G.J. Tyl C.J.H. van de Velde P.D.S. Dijkstra M.I.M. Versteegh

Current 5-year survival after complete resection of pulmonary metastases is ≈ 30%, and many patients develop pulmonary recurrences. Obviously new treatment options are needed for this indication. Isolated lung perfusion (ILuP) is an experimental technique to deliver high-dose chemotherapy to the lung without systemic exposure. Recently, a phase I trial of ILuP combining 45 mg melphalan followed by pulmonary metastasectomy for resectable lung metastases proved to be feasible and safe.

The current 3-center phase II study (including University Hospital Antwerp/P. van Schil and Anthonius Hospital Nieuwegein/F. Schramel) allows patients with resectable lung metastases from colorectal cancer, soft tissue- and osteosarcoma to be treated with ILuP prior to metastasecomy.

At Leiden University Medical Center we treated 8 patients: 4 with colorectal cancer (age 54–59 y), 2 osteosarcoma (19–20 y), 1 sarcoma NOS of bone (38 y) and 1 sarcoma NOS (56 y) of soft tissue. The number of metastases was 1–2 and one patient had resection of 9 metastases. The procedure was uncomplicated in 7 cases and 1 patient had reversible pulmonary edema. Hospital admission duration was 6–8 days in the uncomplicated group and 14 days in the one patient with a complication. No long term toxicity was observed with extensive follow-up including lung function tests. With a median follow-up of 7 months (range 2–16), only the patient with 9 metastases had a recurrence and died of disease.

Our single center prelimininary data show that ILuP is feasible and does not lead to irreversible or severe toxicity. Compared to retrospective data with metastasectomy alone, perfusion did not add toxicity. Follow-up is too short to draw any conclusions on efficacy.


M. Franke M. Kevric C. Int-Veen H. Jürgens B. Kempf-Bielack S. Bielack

Only few patients with osteosarcoma relapse with solitary skeletal lesions as only sign of recurrence. We used the COSS database to learn more about these rare occurrences.

This report covers all patients with high-grade osteosarcoma of the limbs or axial skeleton registered into the COSS database between 1980 and 2003 who developed 1st recurrences as solitary osseous lesions distant from the primary tumour before 01/2005. Patient-, tumour-, and treatment-related variables and outcomes were evaluated.

38 patients (27 male, 11 female) developed solitary osseous recurrences a median of 2.1 years (range:.5 – 14.3) from primary diagnosis. Primary sites had been limbs in 36 and axial in 2, relapses involved axial sites (24), limbs (10), or craniofacial bones (4). Treatment for osseous recurrence included surgery in 28 patients, radiotherapy in 10, and chemotherapy in 27. After a median follow-up of 1.9 years (range:.1–21.2) from 1st recurrence for all 38 patients and 5.5 years (.3–21.2) for 16 survivors (10 of these in continuous 2nd surgical remission), 2- & 5-year overall and event-free survival probabilities were 55% & 34% and 34% & 27%, respectively. A long interval to recurrence (> 1.5 years) predicted for better outcomes (p< .01). For those 21 patients achieving a 2nd complete surgical remission, 2- & 5-year overall and event-free survival probabilities were 81% & 61% and 52% & 49%, respectively, while only 1/17 patients failing to achieve a 2nd complete surgical remission survived beyond 5 years (p< .001) after additional radiotherapy. 14/16 survivors had also received 2nd-line chemotherapy.

1st solitary skeletal recurrences of osteosarcoma seem to have a favourable outcome provided treatment includes complete surgery as part of multimodal therapy. Some presumed bone metastases may rather represent second primary osteosarcomas.

The COSS studies that form the basis of this report were supported by Deutsche Krebshilfe.


S.O. Swaim M.C. Gebhardt

Rotationplasty, or the Van Nes procedure, is a surgical option for reconstruction of the lower extremity after resection of a malignant bone tumor in predominantly skeletally immature patients. The procedure usually involves resection of the femur and knee joint en bloc. Virtually all soft tissues, including skin around the tumor, are excised, and the sciatic nerve is preserved. The vessels can be resected and re-anastamosed or preserved. The leg and foot are rotated 180 degrees and reattached, preserving and/or restoring the nerves and blood supply. The foot and ankle which face posteriorly, then function as a knee joint in a custom-made prosthesis.

Although this procedure has been successfully performed for many years, patients and families cite cosmesis as a major consideration when making this decision. The lack of knowledge and understanding of the functionality, the psychosocial adjustment, and the quality of life with the rotationplasty, also, present challenges for families with respect to acceptance of this surgical choice.

Two case studies will be discussed to demonstrate the biopsychosocial elements of this procedure. These two individuals, 2.5 years and 24 years post-rotationplasty respectively, have attained success in their personal and professional lives, and they have willingly and enthusiastically shared their experiences with patients and families considering this surgical option. Using Roy’s adaptation model, this presentation will focus on adopting positive role modeling to enhance adaptive strategies needed by patients and families to guide their decision making.


Leo Kager Andreas Zoubek Matthias Kevric

Background: The incidence of osteosarcoma varies considerably with age and preschool children are extremely rarely affected. This study was conducted to investigate presentation, treatment, and outcome in very young children with osteosarcoma.

Patients and methods: The authors retrospectively analyzed the data of 2706 consecutive COSS patients with newly diagnosed high-grade osteosacroma of bone and identified 28 patients (1.0%) aged less than five years at diagnosis. Demographic, diagnostic, tumor, and treatment related variables; response and survival data of these 28 were analyzed.

Results: Of the 28 (male, N=16; female, N=12) toddlers, 27 presented with high-grade central osteosarcoma of an extremity (femur, N= 12; humerus, N=10; tibia, N=5) and one with a secondary osteosarcoma of the orbit. The size of primary extremity tumors was large (≥ 1/3 of the involved bone) in 20/27 evaluable patients. Primary metastases were detected in 4 children. All patients received multiagent chemotherapy, and 13/20 analyzed tumors responded well (> 90% necrosis) to neoadjuvant chemotherapy. Limb sparing surgery was performed in 11, ablative procedures were performed in 14, and no local surgery was performed in two patients with extremity tumors. With a median follow-up of 3.8 years (6.2 years for survivors), 13 patients were alive (CR1, N=12; CR3, N=1). Four patients never achieved a complete remission and 12 developed recurrences (local, N=3; metastatic, N=8; site unknown, N=1); and 15 of these 16 patients died. Five-year overall and event free survival probabilities were 50% (SE 10%) and 46% (SE 10%). Better survival was correlated with good response to chemotherapy.

Conclusions: Osteosarcoma is extremely rare in pre-school children. These young patients often have large tumors which may require mutilating resections. Prognosis may be poorer than in older patients.


Full Access
N.A.C. Leijerzapf P.D.S. Dijkstra A.H.M. Taminiau

A rotationplasty is a unique surgical procedure used to reconstruct after resection of a tumor of the leg or a congenital defect. This procedure avoids phantom pain, limb length discrepancy and infections or implant related complications. The outcome is unusual for cosmesis but very functional.

Background: Borggreve first described a rotationplasty in Germany in 1930 for a 12 year old patient whose knee was destroyed by tuberculosis. In 1950 Van Nes modified the procedure. Kotz and Saltzer described in 1982 the use of a modified version of a rotationplasty to treat malignant tumors of the distal femur.

Case studies of two such patients will be presented.

A 27 year old man had a non-metastic osteosarcoma of his distal femur at the age of five. He underwent chemotherapy and a rotationplasty. Six years after his operation a correction osteotomy was done. He is doing very well physically and mentally. He graduated business studies, went yearly on Alpine skiing on two legs, likes jogging and perceives no limitations in his life (MSTS, TESS, SF-36).

A 24 year old man, 14 years after a Ewing-sarcoma of his hip. He underwent chemotherapy and radiation therapy. Thirteen years later he had a pathological fracture after playing soccer. He was treated with a total hip prosthesis without screening the malignancy. However the pathology of the specimen showed a postradiation sarcoma. He underwent a modified Van Nes rotationplasty (knee for hip and ankle for knee).

Although is said that rotationplasty had a poor cosmesis and poor psychosocial acceptance, this is not our experience.


A. Anazado A. Flanagan R. Tirabosco T. Briggs S. Cannon J. Skinner R. Pollock A. Cassoni J. Whelan M. Michelagnoli

Medical records of children < /=5 years, treated by the London sarcoma service for malignant primary bone tumours (average new cases osteosarcoma (OS)/Ewings sarcoma (ES), all ages: 125/year) between 1999 and 2009, were reviewed.

Results: 5 OS and 6 ES. Mean age – 4.2 years (range 2.1–5.8), 8/11 males. OS primary sites: distal femur (2), proximal femur (1) and proximal humerus (2); localised tumours only. Primary sites in the ES cohort included 1 distal femur, 2 chest wall (1 – spinal extension), 1 buttock (spinal extension), 1 temporal bone and 1 ulna; 1 had bone/bone marrow involvement, 1 had chest metastases. 4/5 OS (Euramos, MRC B007) and 5/6 ES (Euro-Ewings 99) were entered into phase III clinical trials. Delayed surgery for OS occurred at mean 12.1 weeks (range 11–13) – 4 limb salvage prostheses with 2/4 non-invasive growers, 1 forequarter amputation. All had a good (> 90% necrosis) histologic response to neoadjuvant therapy. Delayed surgery for ES occurred at mean 21.7 weeks (range 12.8 – 35), 1 limb salvage with prosthesis (non-invasive grower), 1 biological reconstruction; remainder had tumour resections. Histologic response: 50% good. In the OS cohort, 1 child died a toxic death; 1 developed pulmonary metastases and died 2 years from diagnosis; 1 has a metastatic recurrence in the opposite humerus 2 years from diagnosis and starts 2nd line therapy; 1 had local recurrence 1 year from diagnosis but alive at 7.4 years;1 alive/disease free at 2.5 years. In the ES cohort 5/6 are alive disease free -1, 4.1, 5.2, 6.9 and 7 years from diagnosis; 2 needed 2nd line therapy for recurrent distant disease 4.5 and 5.8 years off therapy, 1 of whom has just recurred again (6.1 years from diagnosis).

Conclusion- improving early survival rates in the very young with OS remains a significant challenge. Quality of survival requires further age-appropriate study.


M. Guillon P. Mary L. Brugière P. Marec-Berard H. Pacquement C. Schmitt C. Habay P. Lemoine C. Verite J.M. Guinebretière M.D. Tabone

Osteosarcoma rarely affects young children. To determine the clinical characteristics and the prognosis of this cancer in children of less than 5 years at diagnosis, we retrospectively analysed medical records of these patients treated in French centers between 1980 and 2007. A centralised histological review was carried out.

Fifteen patients were studied. Long bones were involved in 14 cases. Metastases at diagnosis were observed in 40% of patients. Histologic type was 74% osteoblastic.

In 3 cases (20%) tumours occurred on a particular background (tall constitutional size, treatment with growth hormone and pregnancy induced by clomiphene). One child had a second cancer 13 years after the first diagnosis.

Twelve children received pre-operative chemotherapy including high dose methotrexate: 5 of them had progressive disease; only 36% had good histological response (less than 10% viable cells). Limb salvage surgery was performed in six cases (40%).

Chemotherapy was well tolerated in most patients. A one-year-old child developed a severe late convulsant encephalopathy with lesions of the white substance that could be due to methotrexate despite adjustment of doses to his weight.

The functional recovery of the three analysable children who underwent limb salvage surgery is uneven and shows frequent mechanical or infectious complications (2 to 5 reinterventions per patients).

First complete remission (CR) was obtained in 12 children, six of them relapsed. With a median follow-up of 15 years, six are alive in CR, six died of disease (40%), two were lost to follow-up and one has stable disease with metastasis.

This study shows that osteosarcoma seems to be more aggressive in children under five years of age. Surgical management remains difficult in this population. Prospective studies are still needed to confirm these observations.


S.J. Smith L. Case

Cancer is a major health problem for teenagers and young adults (TYA’s). However, many young people are often late to receive a cancer diagnosis. Young people may not recognize symptoms as serious and delay seeking help. Furthermore, there is evidence to suggest that once a young person does seek help from a general practitioner (GP), significant delay can still occur.

During the annual Find Your Sense of Tumour (FYSOT) conference 2007; a group of 200 TYA’s with cancer participated in a survey regarding their diagnostic experience; the cohort included 22 patients with bone tumours. Following the onset of symptoms; nearly half of the TYA’s with a bone tumour (46%) reported 4 or more visits to their G.P before being referred to a specialist. However, 91% of bone tumour patients had multiple, ‘classic’ cancer symptoms and the majority (77%) sought help from the G.P within 4 weeks of noticing symptoms.

The ‘Christie Crew’ (CC) are a group of TYA’s who have been treated for cancer and work on various projects to improve cancer services. The Christie Crew wanted to empower young people with the knowledge that TYA’s do get cancer and to raise awareness of the signs and symptoms of cancer and have produced a DVD and education pack that has been launched across 80 schools and throughout the North West.

The DVD is highlights individual’s stories of diagnosis. There is also a poster campaign highlighting signs and symptoms of cancer being displayed in large public venues across the Manchester area. The aim is to roll out the project nationally as part of the health awareness (Healthy Schools) initiative. By highlighting that young people get cancer it is hoped that more young people will recognise the signs and symptoms and be empowered to go to their GP if they have persistent problems.


K. Roberts A. Mann

In 2008 The Christie was chosen by Manchester United Football Club to form a unique partnership. This funded a specialist Physiotherapist and Occupational Therapist to work exclusively on the Young Oncology Unit, creating the first posts of their kind in the UK. The YOU treats patients between 16–24 years old with a diagnosis of cancer, sarcoma being one of the most common in this age group. All patients attending the YOU now receive a fully comprehensive Physiotherapy and Occupational Therapy service to address their rehabilitation needs.

The NICE guidelines (2005) indicate that cancer care for young adults needs to be age specific, age appropriate and undertaken by appropriately trained staff; hence the importance of having specialist therapists on the YOU.

The needs of teenagers and young adults with cancer, both physically and psychologically, are more critical than at any other time in life. During their treatment patients will experience stressful events, such as alopecia, weight loss or gain, altered physical appearance, fatigue, nausea and vomiting, absence from education, and reduced contact with peers. The Physiotherapy and Occupational Therapy roles are essential in enabling young adults to adapt to their diagnosis and learn coping strategies to deal with the stressful events they encounter through their cancer experience.

During this presentation we will describe the unique role of Physiotherapy and Occupational Therapy with teenagers and young adults, using case studies to illustrate the benefits of having dedicated YOU therapists. We will also share with you the innovative ways in which the Manchester United training facilities have been used for different initiatives that have greatly benefitted and motivated our patients and their families. The partnership between two local organisations, one of the biggest football clubs in the world and a world class Cancer Centre has been a unique and positive liaison.


L. Russell L. Suckling

Objectives: Background: In 1999 all General Practitioners (GPs) in the UK were sent guidelines about the criteria for urgent referral of patients with suspected sarcoma. In addition, the receiving specialist centre was given a set of targets to meet in relation to referral, diagnosis and treatment of these cancers. These targets have now been updated for 2008 in the Cancer Reform strategy.

Aim: To compare the clinical information on two-week wait referrals with imaging clinical assessment within a specialist centre to confirm a malignant diagnosis; to review sarcoma diagnosis hit-rate and to establish whether early diagnosis has been improved.

Methods: All two-week wait referrals direct into our department were studied from June 2007 to June 2008 to determine whether a sarcoma was diagnosed, whether the GP criteria were met, and whether the targets were achieved.

Results: A total of 166 referrals received as two-week referrals to the specialist unit. One hundred and thirty six were diagnosed with benign lesions. Thirty patients had a malignant diagnosis and of those 10 patients had surgery as their first definitive treatment.

Conclusions: Detailed analysis is still being undertaken but initial conclusions drawn seem to suggest that there are still a large number of inappropriate referrals being made under the two week wait. This may be due to the GPs not following the criteria on the referral form.


L. Richards M. Cumbo

The Specialist Sarcoma Physiotherapist aims to ensure that patients with sarcoma receive a coordinated and seamless rehabilitation programme, when and where they need it, to enable them to achieve maximum function and quality of life. The National Institute of Clinical Excellence (NICE) Sarcoma guidelines (NICE 2006), recommend that all patients should have their care supervised by, or in conjunction with a sarcoma Multidisciplinary team (MDT). The role of the specialised physiotherapist on the MDT enables rehabilitation to be provided in a timely and coordinated way (NICE 2006).

Sarcoma and its treatment can have a major effect on the quality of patients’ lives. Treatment often involves extensive surgery, coupled with chemotherapy and/or radiotherapy. Rehabilitation of patients with sarcoma is highly specialised. A Specialist Sarcoma Physiotherapy team was set up at The Christie and Manchester Royal Infirmary in 1998. All patients who need it, can access expert rehabilitation and advice. The physiotherapist is a core member of the MDT, attends clinics, MDT meetings and offers seamless rehabilitation to in-patients and out-patients undergoing treatment (surgery, radiotherapy and chemotherapy) for bone or soft tissue sarcoma.

The physiotherapist must have an in-depth understanding of all aspects of sarcoma: treatment modalities, functional and psycho-social issues, and impact of disease progression, etc. Rehabilitation is often intensive and may take months and sometimes years. The physiotherapist will spend many hours with the patient and develops a close relationship where practical as well as emotional advice and counselling become part of the treatment. In the event of metastatic disease, the physiotherapist continues to offer support and helps to maximize independence and function even in the end stages of the disease. Access to specialist advice and rehabilitation helps the patient maximise the benefits of treatment, and aims to improve physical, social and emotional outcomes both during and following treatment.


Full Access
G. Egberts A.C. Biswana Dr. Jutte Dr. J. Hoekstra-Weebers

Background: Diagnosis and treatment of cancer are highly stressful for patients. Everyday life is disrupted for the vast majority of patients and their relatives and the cancer experience often results in physical, psychological, social, practical, and spiritual concerns.25% to 40% of cancer survivors continue to suffer from distress.

Goal: To improve the referral to specific professionals.

Intervention: Implementation of the distress thermometer: for the future demand on healthcare, a National Cancer Control Program was developed. Two objectives are the availability and introduction of a validated screening instrument capable of indicating the need for specialized psychosocial assistance and the inclusion of screening for psychosocial problems in the national guidelines for oncologic care. These 2 objectives are in line with the American National Comprehensive Cancer Network (NCCN) practice guideline of distress management. This program introduced the Distress Thermometer (DT), an easily understood, self-reported measure of distress. Patients are asked to rate their overall distress on a visual analogue scale (a thermometer) from 0 (no distress) to 10 (extreme distress).

Implementation: Baseline measurements were done in 2008. In January 2009 we started using the distress thermometer at the orthopedic oncology outpatient clinic. The first results of the baseline measurements and the implementation so far will be presented during the EMSOS 2009.


A. J. Hughes

The aim of this audit is to evaluate the patient experience of a nurse led follow up clinic for patients with sarcoma.

Those attending follow up in March 2009 were asked to participate in the audit by completing a short questionnaire. The aim of this questionnaire was to evaluate their clinic experience. It gathered their thought and feelings on being seen by a nurse rather than a doctor and whether they felt that had any implication on their satisfaction with the appointment.

The audit is on-going it is expected that the results will be available for presentation at the EMSOS Nurse Symposium in May 2009.


Full Access
D. de Klerk G. Grootenhuis ten Harkel-Dekker I.M.S. Heijnen

The orthopedic ward was lacking a moment of evaluation with the patient to discuss the provided care. Also there was insufficient insight in the problems in the home situation after discharge from the hospital.

To solve these problems we started with a nursing discharge protocol. In this protocol we introduced the telephone consult. When a patient knows when he will be dismissed he gets a discharge conversation where he will be informed concerning the telephone consult and gets a short questionnaire. In this questionnaire we ask the patient about there opinion of the provided multidisplinary care in the hospital. A week after discharge the patient will be rang at home to discuss if problems occurred in the homesituation and the questionnaire will be gone through. The data originated from this telephone conversation are processed in a database, so that this information can be used to improve the quality of care.

After half a year we evaluated this telephone consult. Patients experience the personal contact after discharge as valuable, problems are traced early and a number of quality improvements has been carried out as a result of the information from the telephone consult.

The information from the telephone consult is very valuable. It concerns an ongoing process which can be used for fast and effective improvements. The data from the database can also be used for scientific research at multidisciplinary level.


Full Access
C. Carlos L. Nancy M. Rui S. Dina

Surgical wounds are a problem in bone cancer patients undergoing aggressive orthopedical surgeries, such as hemipelvectomy and hip-disarticulation, which are very aggressive to the tissues. Regarding the wound care, the development of Negative Pressure Wound Therapy (NPWT) has shown to have better results than the standard methods often used in wound care. V.A.C.® Therapy removes fluids and infectious materials, helps protect the wound environment, helps promote perfusion and a moist healing environment and helps draw together wound edges. So, V.A.C.® Therapy has shown to provide cost-effective and clinically proven wound therapy.

The aim of our study is to describe nursing care in the management of V.A.C.® Therapy, having in mind the benefits that this therapy will bring to the patient, such as reduced complications, reduced costs and time spent on the ward, helping preparing their discharges.


Karin Kaesler-te Plate Oncology nurse

University Medical Centre St. Radboud Nijmegen has started the project Continuity of Care and Logistics for adult patients with bone tumors in the spring of 2007 (sarcoma chain). This project is focused on the patient group in a multi professional way. Within this project there also has been looked at the information transfer between different, at the patient involved departments on nursing level.

Transfer between the orthopedic outpatient clinic (gateway specialism for this patient category) and the orthopedic ward goes well, because a nursing pre admitting interview takes place at the outpatient clinic. The report of this interview goes to the orthopedic ward together with the medical chart of the patient.

If the patient is diagnosed with osteo sarcoma or Ewing sarcoma the patient is referred to the department of medical oncology for neo-adjuvant chemotherapy. Between department orthopedics and department medical oncology there is no form of information transfer on nursing level.

To guarantee an improvement of continuity of care for this patient group consultations were held with senior nurses linked to these departments.

From this consultation became clear that there was, however, need for better information exchange.

Since the January 1st 2008 patients who are referred to the department medical oncology by means of the orthopedic outpatient clinic are transferred personally and in writing (copy of the pre admitting report and a summary of the hospitalization for the biopsy) to the nurse coordinator of the medical oncology ward. Because this takes place before the first admittance of the patient on the medical oncology ward it is already clear what the (potential) care problems are. It is also clear how the patient has experienced his sickness process up to that moment and if there are psychosocial problems at hand.

Because of this the nurses who are going to take care of this patient can anticipate and improve their care regarding the personal needs of the patient. Until now not many patients have been transferred this way. This because we have many young patients (children) who go to the children’s oncology ward. This department has not participated so far, at nursing level, at this project. Evaluation of this new manner of transfer takes place in March 2009.


N.A.C. Leijerzapf P.D.S. Dijkstra A.H.M. Taminiau

Purpose: Surgery is the only treatment option for chondrosarcoma grade I. Because this cartilage tumour is found by coincidence, patients feel unsafe, are anxious and very emotional. The purpose of this study was to evaluate the psychological and social impact of a chondrosarcoma grade I and to optimize the care of these patients.

Patients and methods: Eighty-two patients with a mean age of 50 years (22 – 80), who underwent surgery because of a chondrosarcoma grade I between 1990 and 2007, participated in this retrospective multi-method study. Assessment followed using, the Short Form-36, the MSTS and a special developed semi-structured questionnaire. The mean follow-up time was 4,8 year. 66 patients had a curettage, fenolisation and bonegraft. Sixteen patients had a resection. Five of them underwent a reconstruction with an allograft and another five a reconstruction with prosthesis.

Results: The majority of the patients (77%) were satisfied with our information. For mortgage and life/health insurance there were consequences in 18% of the patients. The SF-36 displayed slight lower scores in all domains except for mental health. Satisfaction with the operation is connected to emotional acceptance.

Conclusions: For patients afflicted by chondrosarcoma grade I the psychological impact is enormous. Three-quarter of the patients think often about the diagnosis and 40% was concerned about the waiting time before operation. To a lesser extent, patients were concerned about the impact of the chondrosarcoma on their lives. Within both domains, psychological as well social, there is a task for the nurse practitioner or a social worker in improving care of these patients. The extent of the surgical procedure does not influence patient satisfaction. The emotional acceptance of the disease decides the level of patient satisfaction.


J.E. Allen

Improvement in survival for teenagers and young adults (TYAs) has lagged behind those of children and adults, (Stiller et al 2006). In seeking explanations investigators have focused on two main factors. Firstly, the low accrual of TYAs into clinical trials (Newburger et al, 2002), and secondly the lack of appropriate multidisciplinary care (Stevens, 2005).

Data from the UK Office of National Statistics confirms this with 70% of paediatric patients being entered into a clinical trial compared to only 20% of 15–24 year olds. In 2007 the Teenage Cancer Trust (TCT) asked over 200 14–25 year olds with cancer if they had been offered a clinical trial (TCT survey results, 2008). Of the total cohort only 30% reported that they had been given the opportunity to enter a clinical trial. The National Cancer Research Institute (NCRI) established a Teenage and Young Adult Clinical Studies Development Group in 2005 to address the issues surrounding the accrual of TYAs into clinical trials.

At a specialist Teenage Cancer Trust Unit in the UK a TYA Clinical Research Nurse was appointed in May 2008; in order to improve TYA accrual into clinical trials. An audit is currently been undertaken to examine present data of clinical trial entry and retrospective data from 2006 and 2007. The focus of the audit is on patients aged 16–24 years with a bone or soft tissue sarcoma being treated in one TCT unit in the UK.

The audit will examine whether the appointment of a TYA research nurse has influenced the accrual of TYA patients into clinical trials. The paper will focus on the particular difficulties and challenges with recruiting TYA patients and the developing role of the TYA Research Nurse in influencing practice. It is essential that improvements are made with regard to trial entry for this unique age group and the TYA Research Nurse may play a vital role in this in the future.


C. Carlos L. Nancy M. Rui S. Dina

Metastatic bone cancer is a type of bone cancer that occurs more commonly than primary bone cancer. In the development of the disease, pathological fractures can occur, affecting patient’s quality of life.

The aim of our study is to describe the impact of pathological fractures in patient’s quality of life. This study is based on a retrospective study with 140 patients, who attended the ward of bone and soft tissue tumor unit, regarding the risk of fracture, the nursing intervention and the impact of this type of fractures in patient’s quality of life.


S Berthold C Bodenstein S Heinzmann FH Schilling

Wound care is often a problem after bone surgery. There is growing evidence that honey based products demonstrate efficacy in infected wounds after surgery. Honey has antibacterial effects and supports wound healing. Even drug resistant bacteria can be eliminated by the use of medical honey. Honey is easy to use, cost effective and has low side effects.

We report some of our experience in patients with bone tumours after rotationplasty, amputation and other serious surgery.