Abstract
Purpose: Treatment results in patients with Ewing tumors of the vertebrae were analyzed.
Patients and Methods: Between June 2000 and April 2007 7 patients with primary tumors of the thoracic or lumbar vertebrae were treated. No one patient had primary tumor of the cervical vertebra. The median ageat diagnosis was 13 years (range, 12 to 18 yrs.). Primary sites: thoracic5, lumbar 2. No one had metastases at diagnosis. Surgery was performed in 5 pts. Complete surgical excision in 2 and maximal tumor reduction in 3.Only biopsy was in 2pts. After surgery all pts. received chemotherapy: EICESS 92 (EVAIA chemotherapy regimen) in 4 pts. and Euro Ewing 99 in 3 pts. Radiotherapy was performed in 6 patients: after 2 cycles of chemotherapy in 2 pts., after 3 cycles in 4 pts. Median dose 5040cGy (range 5018–5400cGy) in conventional fractionation. Daily fractionation from 180–193cGy.
Results/Discussion: The mean follow-up was 41 months (range 4–104 months). Overall survival (OS) rate was 71,42 %. One patient progressed and died after complete treatment, another one died during chemotherapy before radiotherapy. In our series of Ewing’s Sarcoma of the vertebrae, good surgery initialy, early definitve radiotherapy and aggressive multimodal therapy (surgery/radiotherapy/chemotherapy) may be effective in disease control and survival.
Correspondence should be addressed to Professor Stefan Bielack, Olgahospital, Klinikum Stuttgart, Bismarkstrasse 8, D-70176 Stuttgart, Germany. Email: s.bielack@klinikum_stuttgart.de
