Aims

Advocates of debridement, antibiotics and implant retention (DAIR) in hip periprosthetic joint infection (PJI) argue that a procedure not disturbing a sound prosthesis-bone interface is likely to lead to better survival and functional outcome compared with revision. This case-control study aims were to compare outcome of DAIRs for infected primary total hip arthroplasty (THA) with outcomes following primary THA and two-stage revision of infected primary THAs.

Aim

Advocates of Debridement-Antibiotics-and-Implant-Retention (DAIR) in hip peri-prosthetic joint infection (PJI) argue that a procedure not disturbing a sound prosthesis-bone interface is likely to lead to better survival and functional outcome compared to revision. However, no evidence supports this. This case-control study's aims were to compare outcome of DAIRs for infected 1° total hip arthroplasty (THA) with outcomes following 1° THA and 2-stage revisions of infected 1° THAs.

Introduction

Native hip joint infection can result in hip arthrosis as a complication requiring the need for subsequent arthroplasty. There is little evidence to support single or staged THA. We present the results of patients who have undergone total hip arthroplasty (THA) following hip joint sepsis in our institution.

Introduction

The value of Debridement-Antibiotics-and-Implant-Retention (DAIR) in prosthetic-joint-infection (PJI) is still a matter of debate as most studies to-date are underpowered with variable end-points. In our, tertiary referral, bone infection unit we consider DAIR to be a suitable option in all PJIs with soundly fixed prostheses, despite chronicity. The aims of this study were to define the long-term outcome following DAIR in hip PJI and identify factors that influence it.

Debridement, antibiotics and implant retention (DAIR) is a surgical option in the treatment of prosthetic joint infection (PJI). It is thought to be most appropriate in the treatment of early (≤6 weeks post-op) PJI. Most studies to-date reporting on DAIRs in hip PJI have been underpowered by reporting on small cohorts (n= <45), or report on registry data with associated biases and limitations. In our, tertiary referral, bone infection unit we consider DAIR to be a suitable option in all cases of PJI with a soundly fixed prosthesis, with early or late presentation, especially in patients who are too elderly or infirm to undergo major surgery.

Aim: To define the 10-year outcome following DAIR in hip PJI and identify factors that influence it.

We retrospectively reviewed all DAIRs performed in our unit between 1997 and 2013 for hip PJI. Only infected cases confirmed by histological and microbiological criteria were included. Data recorded included patient demographics and medical history, type of surgery performed (DAIR or DAIR + exchange of modular components), organism identified and type/duration of antibiotic treatment. Outcome measures included complications, mortality rate, implant survivorship and functional outcome.

121 DAIRs were identified with mean age of 71 years (range: 33–97). 67% followed an index procedure of 1° arthroplasty. 53% included exchange of modular components. 60% of DAIRs were for early onset PJI. Isolated staphylococcus was present in 50% of cases and 25% had polymicrobial infection. At follow-up (mean:7 years, range: 0.3 – 18), 83 patients were alive; 5- and 10- year mortality rates were 15% and 35% respectively. 45% had a complication (persistence of infection: 27%, dislocation: 10%) and 40% required further surgery. Twenty hips have been revised to-date (17%). Performing a DAIR and not exchanging the modular components was associated with an almost 3× risk (risk ratio: 2.9) of subsequent implant failure (p=0.04). 10-yr implant survivorship was 80% (95%CI: 70 – 90%). Improved 10-year implant survivorship was associated with DAIR performed for early PJI (85% Vs 68%, p=0.04). Functional outcome will be discussed.

DAIR is a particularly valuable option in the treatment of hip PJI, especially in the early post-operative period. Whenever possible, exchange of modular implants should be undertaken, however DAIRs are associated with increased morbidity even in early PJI. Factors that predict success of DAIR in late PJI need to be identified.

Introduction

Joint preserving procedures have gained popularity in an attempt to delay arthroplasty in young, dysplastic hips. Excellent results can be achieved with peri-acetabular osteotomy (PAO) in congruent non-arthritic hips. The role of salvage procedures such as the Shelf acetabuloplasty remains undefined. This study aims to determine the long-term survival and functional outcome following Shelf acetabuloplasty and to identify factors that influence outcome.

There is great variability in acetabular component orientation following hip replacement. The aims of this study were to compare the component orientation at impaction with the orientation measured on post-operative radiographs and identify factors that influence the difference between the two. A total of 67 hip replacements (52 total hip replacements and 15 hip resurfacings) were prospectively studied. Intra-operatively, the orientation of the acetabular component after impaction relative to the operating table was measured using a validated stereo-photogrammetry protocol. Post-operatively, the radiographic orientation was measured; the mean inclination/anteversion was 43° (sd 6°)/ 19° (sd 7°). A simulated radiographic orientation was calculated based on how the orientation would have appeared had an on-table radiograph been taken intra-operatively. The mean difference between radiographic and intra-operative inclination/anteversion was 5° (sd 5°)/ -8° (sd 8°). The mean difference between simulated radiographic and intra-operative inclination/anteversion, which quantifies the effect of the different way acetabular orientation is measured, was 3°/-6° (sd 2°). The mean difference between radiographic and simulated radiographic orientation inclination/anteversion, which is a manifestation of the change in pelvic position between component impaction and radiograph, was 1°/-2° (sd 7°).

This study demonstrated that in order to achieve a specific radiographic orientation target, surgeons should implant the acetabular component 5° less inclined and 8° more anteverted than their target. Great variability (2 sd about ± 15°) in the post-operative radiographic cup orientation was seen. The two equally contributing causes for this are variability in the orientation at which the cup is implanted, and the change in pelvic position between impaction and post-operative radiograph.

Cite this article: Bone Joint J 2014;96-B:1290–7

The orientation of the acetabular component is influenced not only by the orientation at which the surgeon implants the component, but also the orientation of the pelvis at the time of implantation. Hence, the orientation of the pelvis at set-up and its movement during the operation, are important. During 67 hip replacements, using a validated photogrammetric technique, we measured how three surgeons orientated the patient’s pelvis, how much the pelvis moved during surgery, and what effect these had on the final orientation of the acetabular component. Pelvic orientation at set-up, varied widely (mean (± 2, standard deviation (sd))): tilt 8° (2sd ±32), obliquity –4° (2sd ±12), rotation –8° (2sd ±14). Significant differences in pelvic positioning were detected between surgeons (p < 0.001). The mean angular movement of the pelvis between set-up and component implantation was 9° (sd 6). Factors influencing pelvic movement included surgeon, approach (posterior >  lateral), procedure (hip resurfacing > total hip replacement) and type of support (p < 0.001). Although, on average, surgeons achieved their desired acetabular component orientation, there was considerable variability (2sd ±16) in component orientation. We conclude that inconsistency in positioning the patient at set-up and movement of the pelvis during the operation account for much of the variation in acetabular component orientation. Improved methods of positioning and holding the pelvis are required.

Cite this article: Bone Joint J 2014; 96-B:876–83.

Recent events have highlighted the importance of implant design for survival and wear-related complications following metal-on-metal hip resurfacing arthroplasty. The mid-term survival of the most widely used implant, the Birmingham Hip Resurfacing (BHR), has been described by its designers. The aim of this study was to report the ten-year survival and patient-reported functional outcome of the BHR from an independent centre.

In this cohort of 554 patients (646 BHRs) with a mean age of 51.9 years (16.5 to 81.5) followed for a mean of eight years (1 to 12), the survival and patient-reported functional outcome depended on gender and the size of the implant. In female hips (n = 267) the ten-year survival was 74% (95% confidence interval (CI) 83 to 91), the ten-year revision rate for pseudotumour was 7%, the mean Oxford hip score (OHS) was 43 (sd 8) and the mean UCLA activity score was 6.4 (sd 2). In male hips (n = 379) the ten-year survival was 95% (95% CI 92.0 to 97.4), the ten-year revision rate for pseudotumour was 1.7%, the mean OHS was 45 (sd 6) and the mean UCLA score was 7.6 (sd 2). In the most demanding subgroup, comprising male patients aged < 50 years treated for primary osteoarthritis, the survival was 99% (95% CI 97 to 100).

This study supports the ongoing use of resurfacing in young active men, who are a subgroup of patients who tend to have problems with conventional THR. In contrast, the results in women have been poor and we do not recommend metal-on-metal resurfacing in women. Continuous follow-up is recommended because of the increasing incidence of pseudotumour with the passage of time.

Introduction

Since the introduction of 3rd generation Metal-on-Metal-Hip-Resurfacing-Arthroplasty (MoMHRA), thousands of such prostheses have been implanted worldwide in younger patients with end-stage hip osteoarthritis. However, no independent centre has reported their medium-to-long term outcome. The aim of this study is to report the ten year survival and outcome of the Birmingham Hip Resurfacing (BHR), the most commonly used MoMHRA worldwide.

INTRODUCTION

Femoral neck narrowing (NN) following Metal-on-Metal Hip Resurfacing Arthroplasty (MoMHRA) is a well-recognised clinical phenomenon. The incidence of resurfaced hips with NN > 10% is reported to be up to 27%. Its pathogenesis is thought to be multi-factorial secondary to stress shielding, impingement, osteolysis secondary to wear/ion particles and as a result of reduced vascularity and pressure effect on cancellous bone secondary to the presence of a soft-tissue mass around the resurfaced hip. Recognised risk factors for its development include: female gender and the presence of a pseudotumour. Serum Chromium (Cr) and Cobalt (Co) are recognised surrogate markers of in-vivo wear of MoMHRA. The aims of this study were to establish whether NN is associated with increased wear.

INTRODUCTION

Studies have suggested that there is a reduction in head-neck-ratio (HNR) associated with MoMHRA. A reduction in HNR at operation would decrease range of movement and increase impingement risk. Impingement could lead to 20 edge loading, increasing wear. Serum ion levels of Chromium (Cr) and Cobalt (Co) are surrogate markers of wear. Although acetabular component orientation has been shown to contribute to wear and PT development, the role of a decrease in HNR has only been highlighted in PT development. This study aimed to measure changes in HNR that occur at resurfacing and determine any gender- and component size-specific differences. In addition it aimed to determine whether changes in HNR could be associated with increased wear.

INTRODUCTION

Although simulation studies have shown superior wear properties of metal-on-metal articulations, increased concern exists regarding the excess in-vivo wear of a small number of Metal-on-Metal-Hip-Resurfacing (MoMHRA) implants. Serum ion levels of Chromium (Cr) and Cobalt (Co) are surrogate markers of wear. Risk factors associated with increased wear include female gender, small components, dysplasia, cup orientation outside safe zone and femoral head downsize during surgery with an associated decrease in Head-Neck-Ratio (HNR). However, these factors are interlinked. This study aims to identify the factors that are most important for subsequent wear of MoMHRA, by performing a multivariate analysis.

This study aims to investigate femoral blood flow during Metal-on-Metal Hip Resurfacing (MMHR) by monitoring oxygen concentration during the operative procedure.

Patients undergoing MMHR using the posterior approach were evaluated. Following division of fascia lata, a calibrated gas-measuring electrode was inserted into the femoral neck, aiming for the supero-lateral quadrant of the head. Baseline oxygen concentration levels were detected after electrode insertion 2-3cm below the femoral head surface and all intra-operative measures were referenced against these. Oxygen levels were continuously monitored throughout the operation. Data from ten patients are presented.

Oxygen concentration dropped most noticeably during the surgical approach and was reduced by 62% (Std.dev +/-26%) following dislocation and capsulectomy. Insertion of implants resulted in a further oxygenation decrease by 18% (Std.dev +/-28%). The last obtained measure before wound closure detected 22% (Std.dev +/-31%) of initial baseline oxygen levels. Variation between subjects was observed and three patients demonstrated a limited recovery of oxygen levels during implant insertion and hip relocation.

Intra-operative measurement of oxygen concentration in blood perfusing the femoral head is feasible. Results in ten patients undergoing MMHR showed a dramatic effect on the oxygenation in the femoral head during surgical approach and implant fixation. This may increase the risk of avascular necrosis and subsequent femoral neck fracture. Future experiments will determine if less invasive procedures or specific positioning of the limb can protect the blood supply to femoral neck and head.

Introduction: Metal-on-metal-hip-resurfacing-arthroplasty (MoMHRA) has been associated with the development of inflammatory pseudotumours(IP), especially in females. IPs have been linked to wear debris, which can be related to metal-ion blood levels. Acetabular component position has been shown to influence wear. We have identified an optimum component orientation minimising IP risk around an inclination/anteversion of 40°/20°±10°. Our aim was to see if this optimal position results in lower metal ions and to identify the boundary of an optimal placement zone for low wear.

Methods: A cohort of 104 patients(60M:44F) with unilateral MoMHRA was studied. Blood tests were obtained at a mean follow up of 3.9 years and serum Co/Cr levels were measured(ICPMS). High metal ion concentrations were defined as Co> 4.1ppb and Cr> 5.2ppb. Radiographic cup inclination/anteversion were measured using EBRA. The differences in ion levels between different orientation zones were investigated. Three orientation zones were defined centered on 40°/20°: Z1-within ±5°, Z2-outside ±5°/within ±10° and Z3-within ±10°.

Results: There was a wide range of cup placements. Females had significantly (p< 0.001) smaller components(mean:51, 44–60) than males(mean: 56, 52–64). Cr levels, but not Co, were higher in females(p=0.002) and those with small femoral components(< 50mm, p =0.03). Patients with cups within Z1 (n=13) had significantly lower Co(p=0.005) and Cr(p=0.001). Males with cups within Z3(n=27) had lower ion levels in comparison to those outside, which were significantly lower for Co(p=0.049) but not Cr(p=0.084). Females had similar ion levels within and out of Z3(Cr/Co: p=0.83/0.84). Co levels were significantly lower in Z1(n=13) in comparison to Z2(n=33)(p=0.048) but Cr levels were not different (p=0.06).

Discussion: MoMHRA cups placed within ±5° of the optimum(40°/20°) had significantly lower metal ions indicating lower wear within this narrow zone. This safe zone, could extend to ±10° for males only. The narrower safe zone coupled with smaller components implanted are possible factors contributing to the increased IP incidence seen in females.

Introduction: The use of highly cross-linked polyethylene (HXLPE) is now commonplace for total hip arthroplasty, however there is no long-term data to support its use. Hip simulator studies suggest that the wear rate of some types of HXLPE is ten times less than conventional polyethylene (UHMWPE). The outcomes of hip simulator studies are not always reproduced in vivo and there is some evidence that HXLPE wear may increase between 5 and 7 years.

Method: A prospective double blind randomised control trial was conducted using Radiostereometric Analysis (RSA). Fifty-four subjects were randomised to receive hip replacements with either UHMWPE liners or HXLPE liners. All subjects received a cemented CPT stem and uncemented Trilogy acetabular component (Zimmer, Warsaw, IN, USA). The 3D penetration of the head into the socket was determined to a minimum of 7 years.

Results: The total liner penetration was significantly different at 7 years (p=0.005) with values of 0.33 mm (SE 0.05 mm) for the HXLPE group and 0.55 mm (SE 0.05 mm) for the UHMWPE group. The steady state wear rate from 1 year onwards was significantly lower for HXLPE (0.005 mm/yr, SE 0.007 mm/yr) than for UHMWPE (0.037 mm/yr, SE 0.009 mm/yr) (p=0.007). The direction of wear was supero-lateral.

Discussion: We have previously demonstrated that the penetration in the first year is creep-dominated, from one year onwards the majority of penetration is probably due to wear. This study confirms the predictions from hip simulator studies which suggest that the wear rate of this HXLPE approaches that of metal-on-metal and ceramic-on-ceramic articulations. HXLPE may have the potential to reduce the need of revision surgery, due to wear debris induced osteolysis. It may also enable surgeons to use larger couples, thus reducing the risk of impingement and dislocation.

Introduction: Metal on metal hip resurfacing arthroplasty(MoMHRA) is an alternative option to THR in the treatment of young adults with OA. A recognised MoMHRA complication is the development of an inflammatory pseudotumour(IP). Diagnosis is made with the aid of US and/or MRI. To-date, no radiographic indication of the presence of IP has been identified. Neck thinning is a recognised phenomenon in MoMHRA hips not associated with any adverse clinical events. Its pathogenesis is considered multi-factorial. Our aim was to establish whether excessive neck narrowing is associated with the presence of a pseudotumour.

Methods: Twenty-seven hips (26 patients) with IP confirmed clinically, radiologically, intra-operatively and histologically were matched for sex, age, pre-operative diagnosis, component size and follow-up with an asymptomatic MoMHRA cohort (Control n=60). For all patients, prosthesis-neck-ratio(PNR) was measured on plain AP pelvic radiographs post-operatively and at follow-up as previously described and validated.

Results: All IP patients (4M:23F) and all (12M:48F) but two controls had a posterior approach at the time of MoMHRA. Post-operatively, there was no difference in the PNR between the two groups (p=0.19). At an average follow up of 3.5 years (range:0.7–8.3), IP patients(mean 1.26, 1.10–1.79) had a significantly higher (p< 0.0001) PNR in comparison to their controls(mean 1.14, 1.03–1.35). Greater neck narrowing occurred in both genders. IP necks had narrowed by an average of 8% (range:3–23). The degree of neck narrowing was correlated with length of survival of implant (p=0.001).

Discussion: This study shows a strong association between IP and neck narrowing. Processes such as impingement and increased wear are considered to be involved in the pathogenesis of both IP and neck narrowing. Furthermore, the presence of an IP, could lead to altered vascularity via a mass effect and further contribute to neck narrowing. Neck narrowing in symptomatic MOMHRA patients should alert surgeons of the possible presence of IP.

Metal on metal hip resurfacing (MMHR) is a popular procedure for the treatment of osteoarthritis in young patients. Several centres have observed masses, arising from around these devices, we call these inflammatory pseudotumours. They are locally invasive and may cause massive soft tissue destruction. The aim of this study was to determine the incidence and risk factors for pseudotumours that are serious enough to require revision surgery.

In out unit, 1,419 MMHRs were performed between June 1999 and November 2008. All revisions were identified, including all cases revised for pseudotumour. Pseudotumour diagnosis was made by histological examination of samples from revision. A Kaplan-Meier survival analysis was performed, Cox regression analysis was used to estimate the independent effects of different factors.

The revision rate for pseudotumour increased with time and was 4% (95% CI: 2.2% to 5.8%) at eight years. Female gender was a strong risk factor: at eight years the revision rate for pseudotumours in men was 0.5% (95% CI 0% to 1.1%), in women over 40 it was 6% (95% CI 2.3% to 10.1%) and in women under 40 it was 25% (95% CI 7.3% to 42.9%) (p< 0.001). Other factors associated with an increase in revision rate were, small components (p=0.003) and dysplasia (p=0.019), whereas implant type was not (p=0.156).

We recommend that resurfacings are undertaken with caution in women, especially those younger than 40 years of age, but they remain a good option in men. Further work is required to understand the patho-aetiology of pseudotumours so that this severe complication can be avoided.

Introduction: Pseudotumours (soft-tissue masses relating to the hip joint) following metal-on-metal hip resurfacing arthroplasty (MoMHRA) have been associated with elevated serum and hip aspirate metal ion levels, suggesting that pseudotumours occur when there is increased wear. This study aimed to quantify in vivo wear of implants revised for pseudotumours and a control group of implants revised for other reasons of failure.

Methods: A total of 30 contemporary MoMHRA implants in two groups were investigated in this Institutional Review Board approved study:

8 MoMHRA implants revised due to pseudotumour;

The linear wear of retrieved implants was measured using a Taylor-Hobson Roundness machine. The average linear wear rate was defined as the maximum linear wear depth divided by the duration of the implant in vivo.

Results: In comparison with the non-pseudotumour implant group, the pseudotumour implant group was associated with:

significantly higher median linear wear rate of the femoral component: 8.1um/year (range 2.75–25.4um/year) vs. 1.79um/year (range 0.82–4.15um/year), p=0.002; and

Similarly, differences were also measured in absolute wear values. The median absolute linear wear was significantly higher in the pseudotumour implant group:

21.05um (range 2.74–164.80um) vs. 4.44um (range 1.50–8.80um) for the femoral component, p=0.005; and

Wear on the acetabular cup components in the pseudotumour group always involved the edge, indicating edge-loading of the bearing. In contrast, edge-loading was observed in only one acetabular component in the non-pseudotumour group of implants. The deepest wear was observed well within the bearing surface for the rest of the non-pseudotumour group. The difference in the incidence of edge-loading between the two groups was statistically significant (Fisher’s exact test, p=0.03).

Discussion: Significantly greater linear wear rates of the MoMHRA implants revised due to pseudotumour support the in vivo elevated metal ion concentrations in patients with pseudotumours. This study provides the first direct evidence to confirm that pseudotumour is associated with increased wear at the MoM articulation. Furthermore, edge-loading with the loss of fluid film lubrication may be the dominant wear generation mechanism in patients with pseudotumour.

Introduction: The use of second generation highly cross-linked polyethylene (HXLPE) is now commonplace for total hip arthroplasty, however there is no long-term data to support its use. Hip simulator studies suggest that the wear rate of HXLPE is ten times less than conventional polyethylene (UHMWPE). The outcomes of hip simulator studies are not always reproducible in vivo. Long term clinical data is required, as there is emerging clinical data, which suggests that some types of second generation HXLPE may have increased wear after 5 years.

Method: A prospective double blind randomised control trial was conducted using Radiostereometric analysis (RSA). Fifty-four subjects were randomised to receive hip replacements with either UHMWPE liners or HXLPE liners. All subjects received a cemented CPT stem and uncemented Trilogy acetabular component (Zimmer, Warsaw, IN, USA). The 3D penetration of the head into the socket was determined to a minimum of 7 years.

Results: The total liner penetration was significantly different at 7 years (p=0.01) with values of 0.33mm (SD 0.17mm) for the HXLPE group and 0.51mm (SD 0.14mm) for the UHMWPE group. The steady state wear rate from 1 year onwards was significantly lower for HXLPE (0.003 mm/yr, SD 0.04 mm/yr) than for UHMWPE (0.03 mm/yr, SD 0.03 mm/yr) (p=0.01). The direction of wear was in the antero-medial direction in both groups.

Conclusion: We have previously demonstrated that the penetration in the first year is creep-dominated, from one year onwards the majority of penetration is due to wear. The wear rate of this second generation HXLPE approaches that of metal on metal bearings. Second-generation HXLPE may have the potential to reduce the risk of revision surgery, due to wear debris induced osteolysis.

Introduction: The development of Inflammatory Pseudotumour (IP) is a recognised complication following Metal on Metal Hip Resurfacing Arthroplasty (MoMHRA), thought to occur secondary to wear and elevated ion levels. Studies have shown that acetabular component orientation influences the wear of metal-on-metal hip replacement bearings. The aims of this study were to investigate the significance of cup orientation in the development of IP, and to identify a ‘safe-zone’ for cup placement with lower-risk for IP development.

Methods: Twenty six patients (n=27 hips) with IP confirmed radiologically, intra-operatively and histologically were matched for sex, age, pre-operative diagnosis, component size and follow-up with a cohort of asymptomatic MoMHRA patients (Control n=58). Radiographic acetabular anteversion and inclination were measured using EBRA. We calculated the distance in degree space of each acetabular component from the optimum position of 40° inclination and 20° anteversion, recommended by the designers, and thus compared acetabular component position between the two groups. Three different zones were tested as possibly optimum for acetabular placement. These were Lewinneck’s Zone (LZ) (inclination/anteversion; 30–50°/5–25°), and two zones defined by ±5° (Zone 1) or ± 10° (Zone 2) about the suggested target of 40°/20°. An optimal placement zone was determined based on a significant difference in IP incidence between components in the zone versus those outside.

Results: There was a wide range in cup orientations; mean inclination and anteversion were similar in the two groups: IP 47.5° (10.1°–80.6°)/14.1° (4.1°–33.6°) Vs Control 46.1° (28.8°–59.8°)/15.6° (4.3°–32.9°). Acetabular components in the IP group were significantly further away from the optimum position of 40°/20° in comparison to the controls (p=0.023). There was no difference in IP incidence between cups positioned within (IP:13/27, Control:35/58) or out of LZ (p=0.09) and within (IP: 2/27, Control: 10/58) or out of Zone 1 (p=0.156). Cups placed in Zone 2 (IP:6/27, Control:27/58) had significantly lower IP incidence versus those outside this zone (p=0.01). The odd’s ratio of developing IP when the cup is positioned out-of Zone 2 was 3.7.

Discussion: This study highlights the importance of ace-tabular component orientation in IP development. On the whole, patients with pseudotumour had acetabular components that were further away from the optimum position in comparison to the controls. However, a small number of IP patients had well-placed components implying that additional factors, possibly patient and/or gender specific, are involved in the development of pseudotumour. Furthermore, we defined an optimum, ‘safe-zone’ of ±10° around the cup position of 40°/20°. Patients with acetabular components outside this safe zone have an increased risk of IP development.

Introduction: Metal-on-metal hip resurfacing arthroplasty (MoMHRA) has gained popularity as an alternative to THR for younger patients with osteoarthritis. A growing concern has been the association of MoMHRA with the development of inflammatory pseudotumours (IP), especially in women. These have been linked to metal-on-metal wear, which can be related to metal ion concentrations. Elevated metal wear debris levels may result from impingement, rim contact and edge loading. Head-neck ratio (HNR) is a predetermining factor for range of movement and impingement. Neck thinning is a recognised phenomenon post-MoMHRA and we have found an association of IP with increased neck thinning based on a case control study. Our aims were to identify HNR changes a hip undergoes when resurfaced and at follow up; and whether greater neck thinning at follow-up could be associated with the presence of elevated metal ions.

Methods: A cohort of 91 patients (57M:34F) with unilateral MoMHRAs were included in this study. Blood tests were obtained at a mean follow up of 3.9 years (range 1.7–7 years) and serum (Co:Cr) ion levels were measured (ICPMS). High metal ion concentrations were defined as Co> 4.1ppb and Cr> 5.2ppb. For all patients, head-neck ratio (HNR) was measured on plain anterio-posterior pelvic radiographs pre-operatively, immediately post-operatively and at follow-up.

Results: Female patients had significantly bigger HNR pre-op (mean=1.35, range:1.22–1.64) compared to males(mean=1.22, range:1.05–1.38) (p< 0.01). Immediately post-op, female HNRs (mean: 1.26, range: 1.14–1.34) were not different to male patients(mean=1.24, range=1.11–1.38) (p=0.11). At follow-up HNR was once again significantly bigger (p< 0.01) in females (mean=1.35, range: 1.21–1.49), compare to males (mean=1.27, range:1.11–1.38). HNR alterations with operation (p=0.00) and at follow-up (p< 0.01) were significantly bigger in female patients. Furthermore, there was a significant correlation between high ion levels and HNR change at follow-up for both Co (p=0.02) and Cr (p< 0.01).

Conclusion: This study identified gender-specific changes in HNR that resurfaced hips undergo, not previously documented. Female hips have greater HNR pre-operatively, compared to male hips, and appear to be biomechanically disadvantaged when resurfaced. A decrease in HNR with resurfacing could result in impingement and lead to processes, known to be more prevalent in females, such as neck thinning, increased wear and IP development. In addition, we highlight a correlation between high ion levels and greater neck thinning at follow-up. Increased neck thinning in symptomatic MoMHRA hips could be secondary to increased wear and should be investigated further radiologically for the presence of IP.

Introduction: Metal-on-metal hip resurfacing arthroplasty (MoMHRA) has gained popularity as an alternative to THR for younger patients with osteoarthritis. A growing concern has been the association of MoMHRA with the development of inflammatory pseudotumours (IP), especially in women. These have been linked to metal-on-metal wear, which can be related to metal ion concentrations. Although cup orientation has been shown to influence wear, the optimum cup position has not been clearly defined. We have identified an optimal cup orientation to minimise IP risk, based on a case controlled study, for inclination/anteversion within ±10° of 40°/20°. Our aim was to see if this optimal position results in lower metal ions, and to identify the boundary of an optimal placement zone for low wear.

Methods: A cohort of 104 patients (60M: 44F) with unilateral MoMHRA was included in this study. Blood tests were obtained at a mean follow up of 3.9 years (range 1.7–7 years) and serum Co and Cr ion levels were measured (ICPMS). High metal ion concentrations were defined as Co> 4.1ppb and Cr> 5.2ppb. Radiographic cup inclination and anteversion were measured using EBRA. The differences in ion levels between different cup orientation zones were investigated. Three orientation zones were defined centered on the target orientation of 40°/20°: Z1 within ±5°, Z2 outside ±5°/within ±10° and Z3: within ±10°.

Results: There was a wide range of cup placements; mean inclination/anteversion were 46.3°(21.5°–64.6°)/15°(2.7°–35.6°). Cr levels, but not Co, were higher in female patients (p=0.002) and those with small femoral components (< 50mm, p =0.03).

For the whole cohort, there was no significant difference in ion levels (Cr: p=0.092. Co=0.075) between cups positioned within Z3 (n=58) versus those outside (n=46 mean). Male patients with cups within Z3 (n=27) had lower ion levels in comparison to those outside Z3, which were significantly lower for Co (p=0.049) but not Cr (p=0.084). Female patients had similar levels within and out of Z3 for both ions (Cr: p=0.83, Co: p=0.84). However, patients with cups within Z1 (n=13) had significantly lower Co (p=0.005) and Cr (p=0.001) than those outside Z1 (n=95). Interestingly, Co levels were significantly lower in Z1 (n=13) in comparison to Z2 (n=33) (p=0.048) but Cr levels were not different (p=0.06).

Discussion: MoMHRA cups placed with ±5° of the ideal position of 40°/20°gave rise to significantly lower metal ions indicating lower wear within this narrow zone, in both sexes. This safe zone, could be extended to ±10° for male patients only. Gender specific factors, such as pelvic anatomy and joint flexibility, could be responsible for the narrower ‘safe’ zone seen in females. The narrower safe zone coupled with smaller components implanted are factors contributing to higher ion levels and hence the increased incidence of IP seen in females.

Roentgen Stereophotogrammetric Analysis (RSA) can predict long-term outcome of prostheses by measuring migration over time. The Exeter femoral stem is a double-tapered highly polished implant and has been shown to subside within the cement mantle in 2 year RSA studies. It has a proven track record in terms of long-term survivorship and low revision rates. Several studies have demonstrated excellent clinical outcomes following its implantation but this is the first study to assess stem migration at 10 years, using RSA.

This is a single-centre study involving 20 patients (mean age: 63 years, SD=7) undergoing primary total hip replacement for degenerative osteoarthritis using the lateral (Hardinge) approach. RSA radiographs were taken with the patient bearing full weight post-operatively, at 3, 6, 12 months and at 2, 5 and 10 years follow-up. The three-dimensional migration of the Exeter femoral stem was determined.

The mean Oxford Hip Score at 10 years was 43.4 (SD=4.6) and there were no revisions. The stems subsided and rotated internally during a 10-year period. The mean migrations of the head and tip of the femoral stem in all three anatomic directions (antero-posterior, medio-lateral & supero-distal) were 0.69 mm posterior, 0.04 mm lateral and 1.67 mm distal for the head and 0.20 mm anterior, 0.02 mm lateral and 1.23 mm distal for the tip. The total migration at 10 years was 1.81 mm for the head and 1.25 mm for the tip.

The Exeter femoral stem exhibits migration which is a complex combination of translation and rotation in three dimensions. Comparing our 10 year with our previous 2 year migration results, the Exeter stems show continued, but slow distal migration and internal rotation. The subsidence continues to compress the cement and bone-cement interface which maintains secure fixation in the long term.

Introduction: Symptomatic abnormal soft-tissue masses relating to the hip joint, such as those described as pseudotumours, are being increasingly reported following metal-on-metal hip resurfacing arthroplasty (MoMHRA). These were found to be locally destructive, requiring revision surgery in a high proportion (75%) of patients. Lymphocyte infiltrations seen in pseudotumours were similar to aseptic lymphocyte vascular associated lesion (ALVAL), which is thought to represent a T-lymphocyte-mediated delayed type hypersensitivity. Therefore, a delayed hypersensitivity reaction to nickel (Ni), chromium (Cr) or cobalt (Co) has been suggested to play a role in pseudotumour aetiology. In patients with bilateral MoMHRA who presented with symptoms on one side, subsequent scans have demonstrated pseudotumours both on the symptomatic and asymptomatic side. Thus, there are concerns that there may be an appreciable number of asymptomatic pseudotumours that surgeons are unaware of and these may eventually become symptomatic.

Aim: The aims of this study were:

to determine the prevalence of asymptomatic pseudotumours after MoMHRA; and

Methods: A total of 201 MoMHRA implanted hips in 158 patients (97 male, 61 female) with a mean age of 56 years (range 33–73 years) were evaluated. The mean follow-up was 61 months (range 13–88 months). Resurfacing devices implanted included 128 Birmingham Hip Resurfacing, 66 Conserve Plus and seven ReCap. The control groups included additional 20 patients, 10 male and 10 female (a mean age 68 years, range 57–80 years) with metal-on-polyethylene total hip arthroplasty and a further 22 age-matched patients (a mean age 55 years) without any metal implants. Ultrasound was used as the initial imaging modality and MRI was used to assess the extent of the identified masses. Patients with a soft-tissue mass had ultrasound-guided aspiration or core biopsy performed. Venous blood samples were collected in all patients for serum cobalt and chromium ion levels analysis using Inductively-Coupled Plasma Mass Spectrometer and lymphocyte transformation tests (LTT). The Oxford Hip Score (OHS) was used to measure the functional outcomes of patients. Acetabular component abduction angle was measured from standardised anteroposterior pelvis radiographs.

Results: Prevalence – Pseudotumours were found in 7 patients (6 female and 1 male). The overall prevalence of asymptomatic pseudotumours was 4%, with a relatively very high (30%) prevalence in females with bilateral implants. Histological examinations showed extensive necrosis of connective tissue, in which there were scattered aggregates of metal particles and a diffuse lymphocyte infiltrate.

Metal Ion Levels – The presence of pseudotumour was associated with significantly higher median serum cobalt levels (9.2mg/L vs. 1.9mg/L, p< 0.001), chromium levels (12.0mg/L vs. 2.1mg/L, p< 0.001), hip aspirate cobalt levels (1182 mg/L vs. 86.2mg/L, p=0.003), and aspirate chromium levels (883mg/L vs. 114.8mg/ L, p=0.006), as well as with inferior functional scores (OHS 41 vs. 47 p< 0.001). There was no significant difference in acetabular cup inclination angle (p=0.51). Lymphocyte Reactivity: A higher incidence and level of enhanced lymphocyte reactivity to Ni (p=0.001), but not to Co or Cr (the principal elements in the CoCr alloy used in metal-on-metal hip resurfacing implants), was found in patients with MoMHRA compared to the patients without MoM implants. However, lymphocyte reactivity to Co, Cr and Ni did not significantly differ in patients with pseudotumours compared to those patients without pseudotumours.

Conclusion: The prevalence of asymptomatic pseudotumours in females was high, especially in females with bilateral MoMHRA implants (30%). The patients with ‘asymptomatic’ pseudotumours were in fact mildly symptomatic. Lymphocyte reactivity to Co, Cr and Ni did not differ in patients with pseudotumour compared to those patients without pseudotumours, suggesting that systemic hypersensitivity type IV reactions, mediated by lymphocyte reactivity to these metals, is not the dominant mechanism in pathogenesis of the soft tissue pseudotumours. Furthermore, pseudotumours were not detected in those patients who had normal levels of cobalt and chromium ions. This suggests that pseudotumours do not occur if MoM articulations are well functioning. Therefore, pseudotumours are likely to be a biological consequence of the large amount of metal debris generated in vivo due to excessive wear.

Recently, a series of locally destructive soft tissue pseudotumour has been reported in patients following metal-on-metal hip resurfacing arthroplasty (MoMHRA), requiring revision surgery in a high percentage of patients. Based on the histological evidence of lymphocytic infiltration, a delayed hypersensitivity reaction to nickel (Ni), chromium (Cr) or cobalt (Co) has been suggested to play a role in its aetiology. The aim of this study was to investigate the incidence and level of hypersensitivity reaction to metals in patients with pseudotumour.

Materials and Methods: 25 patients were investigated in this Ethics approved study:

Group 1: MoMHRA patients with pseudotumours, detected on the ultrasound and confirmed with MRI (n=6, 5 F:1 M, mean age 53 years);

Lymphocyte transformation tests (LTT) were used to measure lymphocyte proliferation responses to metals. Peripheral blood mononuclear cells were isolated from heparinized blood samples using standard Ficoll–Hypaque® (Pharmacia). The PBMC were cultured at a cell density of 106 cells/mL. Culture was set up in the presence of either:

medium alone;

After 5 days of culture, cells were pulsed with [3H]-thymidine and proliferation was assessed by scintillation counting. The stimulation index (SI) was calculated by the ratio of mean counts per minute of stimulated to unstimulated cultures. A SI value of greater than 2.0 was interpreted as a positive result.

Results: A clinical history of metal allergy was reported in 2/6 in Group 1, 2/13 in Group 2, and none in Group 3. In pseudotumour group, the incidence of reactivity to Ni, Co and Cr was 60%, 17% and 0%, respectively. Within Group 2, the reactivity to Ni, Co and Cr was 69%, 8% and 15%, respectively. One control subject had reactivity to Ni. Inter-group comparisons of mean SI values (Kruskal-Wallis non-parametric analysis of variance) showed no significant differences (p> 0.05).

Discussion: The incidence of enhanced lymphocyte response to metals in patients with MoMHRA was more common than the control group. However, in comparison with non-pseudotumour patients, there was no significant difference in the incidence or the level of lymphocyte reactivity in patients with pseudotumour. We conclude that patients with MoMHRA have an enhanced lymphocyte response to metal ions, reflecting exposure and immune reactivity. However, patients with pseudotumours have a similar proliferative response to those without pseudotumours, which suggests that type IV hypersensitivity may not be the cause of the pseudotumours.

Tribological studies of hip arthroplasty suggest that larger diameter metal-on-metal (MOM) articulations would produce less wear than smaller diameter articulations. Other advantages using these large femoral heads implants include better stability with lower dislocation rates and improved range of motion. The aim of the present study was to compare chromium (Cr), cobalt (Co) and titanium (Ti) ion concentrations up to 1-year after implantation of different large diameter MOM total hip arthroplasty (THA).

Methods: Cr, Co and Ti concentrations were measured using a high resolution mass spectrometer (HR-ICP-MS) by an independent laboratory in 110 patients, randomized to receive a large metal-on-metal articulation unce-mented Ti THA from one of the following companies: Zimmer, Smith & Nephew, Biomet or Depuy. Samples of whole blood were collected pre-operatively, and postoperatively at six months and one year.

Summary of Results: At 6 months, whole blood cobalt levels were: (table removed)

Statistical group comparison revealed significant difference for Cr (p=0.006), Co (p=0.047) and Ti (p=< 0.001). With Biomet implants presenting the best results for Cr and Co and Zimmer the highest Ti level.

Discussion: Different implant factors may influence measured metal ion level in whole blood: articular surface wear and implant passive corrosion. Bearing wear may be related to its diameter, quality of the surface finish, component sphericity, radial clearance, manufacturing process (forged vs cast metal) and metal carbon content. Biomet articulation seems to present the best factors selection. Passive corrosion of exposed metallic surfaces is represented by the elevated Ti levels found in all tested systems (Ti was not part of the bearing surfaces). The plasma sprayed acetabular component surface of the Zimmer’s component seems to be responsible for the significant difference in Ti versus the other implants.

Metal on Metal Hip Resurfacing Arthroplasty (MoMHRA) has gained popularity due to its perceived advantages of bone conservation and relative ease of revision to a conventional THR if it fails. Known MoMHRA-associated complications include femoral neck fracture, avascular necrosis/collapse of the femoral head/neck, aseptic loosening and soft tissue responses such as ALVAL and pseudotumours. This study’s aim was to assess the functional outcome of failed MoMHRA revised to THR and compare it with a matched cohort of primary THRs.

Method: We have revised 53 MoMHRA cases to THR; the reasons for revision were femoral neck fracture (Fracture Group, n=21), soft tissue reaction (Pseudotumour Group, n=16) and other causes (Other Group, n=16: loosening, AVN and infection). Average followup was 2.9 years. These MoMHRA revisions were compared with 103 matched controls from a primary THR cohort; matched for age, gender and length of followup. We compared, using the MannWhitney U test, operative time (OT, measured in minutes), and Oxford Hip Score (OHS) between the revised MoMHRA groups and their individual controls. We also compared, using the Kruskal Wallis test, UCLA Activity Score in the revised MoMHRA groups.

Results: There were no differences between the Fracture Group (mean OT 99.6, SD: 30.4; mean OHS 19.8, SD:9.2) and its controls (mean OT 95.9, SD: 31.8; mean OHS 17.3, SD: 7.5) nor between the Other Group (mean OT 129.4, SD: 36.7; mean OHS 22.2, SD: 9.4) and its controls (mean OT 104.4, SD: 39.2; mean OHS 20.3, SD: 10.1) in terms of OT and OHS. The Pseudotumour Group had significantly longer OT (mean 161.6, SD: 24.5, p< 0.001) and worse outcome (mean OHS 39.1, SD: 9.3, p< 0.001) than its controls (mean OT 113.1, SD: 51.7; mean OHS 20.0, SD: 9.2). In the Fracture Group, there were 3 infections requiring revisions. For the Pseudotumour Group, there were 3 recurrent dislocations, 1 femoral artery stenosis and 3 femoral nerve palsies. In the Other Group, there were 2 periprosthetic fractures. There was significant difference (p< 0.001) in UCLA scores between the MoMHRA groups. The Pseudotumour Group had the lowest mean UCLA score of 3.8 (SD: 1.89). The Fracture Group (mean: 7.0, S.D. 2.0) and the Other Group (mean: 6.7, S.D. 2.1) had similar UCLA scores.

Discussion: The results demonstrate that outcome after revision of MoMHRA is dependent upon the indication for revision. Patients revised for soft tissue reactions had significantly worse outcome. Patients with soft tissue reactions are more likely to experience complications and require further surgical intervention. The pseudotumour associated revisions were associated with a significantly prolonged OT. The overall complication rate for the study groups was quite high, with 11 (21%) revised MoMHRA cases experiencing a complication. The Pseudotumour Group had a higher complication rate (37%).

Pseudotumours are a rare complication of hip resurfacing. They are thought to be a response to metal debris which may be caused by edge loading due to poor orientation of the acetabular component. Our aim was to determine the optimal acetabular orientation to minimise the risk of pseudotumour formation.

We matched 31 hip resurfacings revised for pseudotumour formation with 58 controls who had a satisfactory outcome from this procedure. The radiographic inclination and anteversion angles of the acetabular component were measured on anteroposterior radiographs of the pelvis using Einzel-Bild-Roentgen-Analyse software. The mean inclination angle (47°, 10° to 81°) and anteversion angle (14°, 4° to 34°) of the pseudotumour cases were the same (p = 0.8, p = 0.2) as the controls, 46° (29° to 60°) and 16° (4° to 30°) respectively, but the variation was greater. Assuming an accuracy of implantation of ± 10° about a target position, the optimal radiographic position was found to be approximately 45° of inclination and 20° of anteversion. The incidence of pseudotumours inside the zone was four times lower (p = 0.007) than outside the zone.

In order to minimise the risk of pseudotumour formation we recommend that surgeons implant the acetabular component at an inclination of 45° (± 10) and anteversion of 20° (± 10) on post-operative radiographs. Because of differences between the radiographic and the operative angles, this may be best achieved by aiming for an inclination of 40° and an anteversion of 25°.

Introduction: Metal on metal Hip Resurfacing Arthroplasty (MoMHRA) has gained popularity due to its perceived advantages of bone conservation and relative ease of revision to a conventional THR if it fails. This retrospective study is aimed at assessing the functional outcome of failed MoMHRA revised to THR and comparing it with a matched cohort of primary THRs.

Method: Since 1999 we have revised 53 MoMHRA to THR. The reasons for revision were femoral neck fracture (Group A, n=21), pseudotumour (Group B, n=16) and other causes (Group C, n=16: loosening, avascular necrosis and infection). Average follow-up was 3 years months (1.2–7.3). These revisions were compared with 106 primary THRs which were age, gender and follow-up matched with the revision group in a ratio of 2:1.

Results: The mean Oxford Hip Score (OHS) was 20.1 (12–51) for group A, 39.1 (14– 56) for group B, 22.8 (12–39) for group C and 17.8 (12–45) for primary THR group. In group A, there were three infections requiring further revisions. In group B, there were three recurrent dislocations, three patients with femoral nerve palsy and one femoral artery stenosis. In group C, there were no complications. The differences in clinical and functional outcome between group B and the remaining groups as well as the difference in the outcome between group B and control group were statistically significant (p < 0.05).

Conclusions: THR for failed MoMHRA was associated with significantly more complications, operation time and need for blood transfusion for the pseudotumour group. In addition, the revisions secondary to pseudotumour also had significantly worse functional outcome when compared to other MoMHRA revisions or primary THR.

Introduction: Despite the satisfactory short-term implant survivorship of MoM hip resurfacing arthroplasty, symptomatic abnormal periprosthetic soft-tissue masses relating to the hip joint, ‘pseudotumours’, are being increasingly reported. These were found be locally destructive, requiring revision surgery in 75% of patients. Asymptomatic pseudotumours have not been previously investigated.

Methods: The aims were: (1) to investigate the prevalence of asymptomatic pseudotumours; and (2) to investigate their potential association with the level of metal ions. A total of 160 hips in 123 patients with a mean age 56 years (range 33–73) were evaluated at a mean follow-up of 61 months (range 13–88). Radiographs and OHS were assessed. Patients with a cystic or solid mass detected on the ultrasound/MRI had an aspiration or biopsy performed. Cobalt and chromium levels were analysed using Inductively-Coupled Plasma Spectrometer.

Results: Pseudotumours were found in 6 patients (5F: 1M). In 80% of bilateral cases, it was found in both sides. Histological examination showed extensive necrosis and diffuse lymphocyte infiltration. The presence of pseudotumour was associated with higher serum cobalt (9.2 μg/L vs. 1.9μg/L, p< 0.001) and chromium levels (12.0μg/L vs. 2.1μg/L, p< 0.001); higher hip aspirate cobalt (1182 μg/L vs. 86.2μg/L, p=0.003) and chromium levels (883μg/L vs. 114.8μg/L, p=0.006); and with inferior OHS (23 vs. 14 p=0.08).

Discussion: The prevalence of asymptomatic pseudotumour (5%) was higher than previously reported for the symptomatic pseudotumours (1%). There was a sixfold elevation of serum and a twelve-fold elevation of hip aspirate levels of cobalt and chromium in patients with pseudotumours. This suggests that pseudotumours may be a biological consequence of the large amount of metal debris generated in vivo. The association between pseudotumour and elevated metal ion levels might theoretically be explained by either systemic hypersensitivity responses to metal ions or local cytotoxic effects due to a high level of metal ions.

Introduction: Although resurfacing hip replacements are widely used there are few little independent outcome data to support this. The aim of this study was to report the 5 year clinical outcome and 7 year survival of an independent series.

Method: 610 Birmingham hip resurfacings were implanted in 532 patients with an average age of 51.8 years (range 16.5–81.6 years) and were followed for between 2 to 8 years; 120 of this series had minimum five year follow-up. Two patients were lost. There were 23 revisions, giving an overall survival of 95% (95% CI 85–99%) at seven years. Fractured neck of femur (n=13) was the most common reason for revision, followed by aseptic loosening (n=4). There were also 3 patients who had failures that were possibly related to metal debris. At a minimum of 5 year follow-up 93% had excellent or good outcome according to the Harris Hip Score. The mean Oxford Hip Score was 16.1 points (SD 7.7) and the mean UCLA activity score was 6.6 points (SD 1.9). There were no patients with definite evidence of radiographic loosening or greater than 10% of neck narrowing.

Discussion: The results demonstrate that with the Birmingham Hip Resurfacing, implanted using the extended posterior approach, the five year survival is similar or better to the reported survival rates for cemented and hybrid THR’s in young patients.

Conclusions: Considering these patients are young and active these results are good and support the use of resurfacing. However, further study is needed to address the early failures; particularly those related to fracture and metal debris.

Introduction: We report on a group of 20 metal-onmetal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms; these masses we termed pseudotumours.

Methods: All patients underwent plane radiography; CT, MRI and ultrasound investigations were also performed for some patients. Where samples were available histology was performed. Metal ion levels were measured in six patients and one patient had the metal ion levels in the joint fluid measured.

Results: All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. In all cases a soft tissue mass was present in the region of the hip, this was either solid or cystic. The common histological features were extensive necrosis and lymphocytic infiltration. The blood cobalt and chromium levels varied considerably between the six patients that had these measurements. The median blood chromium level was 3.8 μg/L (range 0.8 to 23 μg/L) and that for cobalt was 11.5 μg/L (range 2.1 to 15 μg/L). The synovial fluid sample taken from a single joint contained much higher metal levels, 701 μg/L for chromium and 329 μg/L for cobalt. Twelve of the 20 cases have so far required revision to a conventional hip replacement.

Discussion: This complication is best imaged with ultrasound, and is not detected by normal xray. We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years. The cause of these pseudotumours is unknown and is probably multifactorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudo-tumours will increase.

The presence of pseudotumours, which are soft-tissue masses relating to the hip, after metal-on-metal hip resurfacing arthroplasty has been associated with elevated levels of metal ions in serum, suggesting that pseudotumours occur when there is increased wear. We aimed to quantify the wear in vivo of implants revised for pseudotumours (eight) and of a control group of implants (22) revised for other reasons of failure.

We found that the implant group with pseudotumours had a significantly higher rate of median linear wear of the femoral component at 8.1 μm/year (2.75 to 25.4) than the 1.79 μm/year (0.82 to 4.15; p = 0.002) of the non-pseudotumour group. For the acetabular component a significantly higher rate of median linear wear of 7.36 μm/year (1.61 to 24.9) was observed in the pseudotumour group compared with 1.28 μm/year (0.81 to 3.33, p = 0.001) in the other group. Wear of the acetabular component in the pseudotumour group always involved the edge of the implant, indicating that edge-loading had occurred.

Our findings are the first direct evidence that pseudotumour is associated with increased wear at the metal-on-metal articulation. Furthermore, edge-loading with the loss of fluid-film lubrication may be an important mechanism of generation of wear in patients with a pseudotumour.

We report on a group of 20 metal-on-metal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms. We describe these masses as pseudotumours.

All patients underwent plain radiography and fuller investigation with CT, MRI and ultrasound. Where samples were available, histology was performed. All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, an enlarging mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. Fourteen of the 20 cases (70%) have so far required revision to a conventional hip replacement and their symptoms have either settled completely or improved substantially since the revision surgery. Two of the three bilateral cases have asymptomatic pseudotumours on the opposite side.

We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years after a hip resurfacing. The cause of these pseudotumours is unknown and is probably multi-factorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudotumours will increase.

Introduction: We report on a group of 20 metal-on-metal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms; these masses we termed pseudotumours. All patients underwent plane radiography; CT, MRI and ultrasound investigations were also performed for some patients. Where samples were available histology was performed.

Methods: All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. Fourteen of the 20 cases (70%) have so far required revision to a conventional hip replacement and their symptoms have either settled completely or improved substantially since the revision surgery. Two of the three bilateral cases have asymptomatic pseudotumours on the opposite side.

Conclusions: We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years after a hip resurfacing. The cause of these pseudotumours is unknown and is probably multi-factorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudotumours will increase.

Inflammatory pseudotumours occasionally occur after metal-on-metal hip resurfacing and often lead to revision. Our aim was to determine the severity of this complication by assessing the outcome of revision in these circumstances and by comparing this with the outcome of other metal-on-metal hip resurfacing revisions as well as that of matched primary total hip replacements.

We identified 53 hips which had undergone metal-on-metal hip resurfacing and required revision at a mean of 1.59 years (0.01 to 6.69) after operation. Of these, 16 were revised for pseudotumours, 21 for fracture and 16 for other reasons. These were matched by age, gender and diagnosis with 103 patients undergoing primary total hip replacement with the Exeter implant.

At a mean follow-up of three years (0.8 to 7.2) the outcome of metal-on-metal hip resurfacing revision for pseudotumour was poor with a mean Oxford hip score of 20.9 (sd 9.3) and was significantly worse (p < 0.001) than the outcome for fracture with a mean Oxford hip score of 40.2 (sd 9.2) or that for other causes with a mean Oxford hip score of 37.8 (sd 9.4). The clinical outcome of revision for pseudotumour was also significantly worse (p < 0.001) than the outcome of matched primary total hip replacements. By contrast, the outcome for fracture and other causes was not significantly different from that of matched primary total hip replacements (p = 0.065). After revision for pseudotumour there were three cases of recurrent dislocation, three of palsy of the femoral nerve, one of stenosis of the femoral artery and two of loosening of the component. Five hips required further revision. In three of these there was evidence of recurrent pseudotumour, and one is currently awaiting further revision. The incidence of major complications after revision for pseudotumour (50%) was significantly higher (p = 0.018) than that after revision for other causes (14%).

The outcome of revision for pseudotumour is poor and consideration should be given to early revision to limit the extent of the soft-tissue destruction. The outcome of resurfacing revision for other causes is good.

Introduction: Avascular necrosis of the femoral head after resurfacing hip replacement is an important complication which may lead to fracture or failure. We compared the changes in femoral head oxygenation resulting from the anterolateral approach to those resulting from the posterior approach.

Methods: In 22 patients undergoing hip resurfacing surgery, a calibrated gas-sensitive electrode was inserted supero-laterally in the femoral head via the femoral neck following division of the fascia lata. Inter-operative X-ray confirmed correct electrode placement. Baseline oxygen concentration levels were recorded immediately after electrode insertion. All results were expressed relative to this baseline, which was considered as 100% relative oxygen concentration. Oxygen levels were monitored continuously throughout the operation. 10 patients underwent surgery through the posterior approach, 12 patients through the antero-lateral approach.

Results: During the operation patterns were similar for both groups, except following joint relocation and soft tissue reconstruction; oxygen concentration recovered significantly in the anterolateral group only. The posterior approach resulted in significantly lower (p< 0.01) oxygen concentration at the end of the procedure (22%, SD 31) than the antero-lateral approach (123%, SD 99).

Discussion and Conclusion: The anterolateral approach disrupts the femoral head blood supply significantly less than the posterior approach in patients undergoing resurfacing. The incidence of complications related to avascular necrosis might be decreased by adopting blood supply conserving surgical approaches.

Introduction: Optimal positioning of the femoral component in hip resurfacing is determined by accurate guidwire placement in the centre of the femoral neck. This can be a challenging procedure. The more extensile approach needed, patient size, the shape of the femoral head and the presences of osteophytes can all result in sub-optimal guidewire positioning and ultimately in varus insertion or femoral notching both of which have been shown to increase the risk of post-operative fracture, the commonest cause of implant failure. Various alignment guides are available but these are cumbersome and time consuming and their accuracy is highly operator dependent. Anecdotally, accuate guidewire insertion is regarded as the most challenging part of this procedure with heightened anxiety levels particularly when low down on the‘learning curve’.

Methods: We describe the technique, difficulties and learning curve experienced with the first ten navigated hip resurfacing procedures at our institution. Post-operative radiographs were obtained and randomly incorporated into a series of 40 post-operative resurfacing radiographs. Radiographic assessment was undertaken by a senior colleague with experience of over 600 resurfacing procedures (blinded to which cases utilised navigation) and classified as poor, satisfactory or good.

Results: The use of navigation in femoral resurfacing has a definite but short learning curve. It provides a means of achieving excellent alignment of the femoral component without any subjective increase in operation time. Anxiety levels associated with accurate guidewire positioning are greatly reduced. Navigation should offer benefits to all surgeons particularly those low down on the ‘learning curve’ for this procedure reducing the risk of femoral component malpositioning and early failure.

We report 17 patients (20 hips) in whom metal-on-metal resurfacing had been performed and who presented with various symptoms and a soft-tissue mass which we termed a pseudotumour. Each patient underwent plain radiography and in some, CT, MRI and ultrasonography were also performed. In addition, histological examination of available samples was undertaken.

All the patients were women and their presentation was variable. The most common symptom was discomfort in the region of the hip. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. To date, 13 of the 20 hips have required revision to a conventional hip replacement. Two are awaiting revision.

We estimate that approximately 1% of patients who have a metal-on-metal resurfacing develop a pseudotumour within five years. The cause is unknown and is probably multifactorial. There may be a toxic reaction to an excess of particulate metal wear debris or a hypersensitivity reaction to a normal amount of metal debris. We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause.

The creep and wear behaviour of highly cross-linked polyethylene and standard polyethylene liners were examined in a prospective, double-blind randomised, controlled trial using radiostereometric analysis.

We randomised 54 patients to receive hip replacements with either highly cross-linked polyethylene or standard liners and determined the three-dimensional penetration of the liners over three years.

After three years the mean total penetration was 0.35 mm (SD 0.14) for the highly cross-linked polyethylene group and 0.45 mm (SD 0.19) for the standard group. The difference was statistically significant (p = 0.0184). From the pattern of penetration it was possible to discriminate creep from wear. Most (95%) of the creep occurred within six months of implantation and nearly all within the first year. There was no difference in the mean degree of creep between the two types of polyethylene (highly cross-linked polyethylene 0.26 mm, SD 0.17; standard 0.27 mm, SD 0.2; p = 0.83). There was, however, a significant difference (p = 0.012) in the mean wear rate (highly cross-linked polyethylene 0.03 mm/yr, SD 0.06; standard 0.07 mm/yr, SD 0.05). Creep and wear occurred in significantly different directions (p = 0.01); creep was predominantly proximal whereas wear was anterior, proximal and medial.

We conclude that penetration in the first six months is creep-dominated, but after one year virtually all penetration is due to wear. Highly cross-linked polyethylene has a 60% lower rate of wear than standard polyethylene and therefore will probably perform better in the long term.

Few independent studies have reported the outcome of resurfacing arthroplasty of the hip. The aim of this study was to report the five-year clinical outcome and seven-year survival of an independent series.

A total of 610 Birmingham Hip Resurfacing arthroplasties were performed in 532 patients with a mean age of 51.8 years (16.5 to 81.6). They were followed for between two and eight years; 107 patients (120 hips) had been followed up for more than five years. Two patients were lost to follow-up. At a minimum of five years’ follow-up, 79 of 85 hips (93%) had an excellent or good outcome according to the Harris hip score. The mean Oxford hip score was 16.1 points (sd 7.7) and the mean University of California Los Angeles activity score was 6.6 points (sd 1.9). There were no patients with definite radiological evidence of loosening or of narrowing of the femoral neck exceeding 10% of its width. There were 23 revisions (3.8%), giving an overall survival of 95% (95% confidence interval 85.3 to 99.2) at seven years. Fractured neck of femur in 12 hips was the most common indication for revision, followed by aseptic loosening in four. In three hips (three patients) (0.5%), failure was possibly related to metal debris.

Considering that these patients are young and active these results are good, and support the use of resurfacing. Further study is needed to address the early failures, particularly those related to fracture and metal debris.

Significant proximal femoral bone deficiency in revision hip surgery poses a considerable challenge, especially as revision hip surgery is increasing in prevalence. Many femoral prosthetic devices, which compensate for this bone loss, are available to surgeons but ideally one wants to restore viable proximal bone stock. The Oxford Universal Hip (OUH) has been designed and modified with these challenges in mind. This is atrimodular, non-locking device that allows for some rotation and subsidence in the cement. Load transfer occurs at the proximal wedge, thus avoiding proximal stress shielding. The OUH has been used extensively in both primary and revision hip surgery and is particularly useful when used in conjunction with proximal impaction bone grafting. The main aim of this study was to determine the clinical outcome of the patients. The viability and survivorship of the impacted bone graft was assessed in order to give some indication of adequate perfusion of the incorporated bone grafting.

Between 1999 and 2002 the OUH, in combination with proximal impaction bone grafting, was implanted in 72 hip revisions in 69 patients. All patients were clinically evaluated using the Oxford Hip score. Histological samples of impacted bone grafting were analysed by a pathologist 2 years after implantation to assess viability and perfusion of the impacted bone graft.

The Oxford Hip Score improved from a pre-operative to a post-operative score of 45 (26–58) to 24.3 (12–43) respectively (p< 0.001). The mean follow up time was 32.7 months and in that time there were no re-revisions for aseptic loosening. Histology demonstrated viable bone stock in the proximal femur where bone grafting had been impacted 2 years previously.

The OUH is a versatile hip prosthesis for use in revision hip arthroplasty and is especially well suited to proximal impaction bone grafting where it is possible to restore viable bone stock

Bone stock loss secondary to debris and mechanic alin-stability presents a challenge in revision hip arthroplasty. The aim of our study is to evaluate the clinical outcome of revision hip arthroplasty using the Oxford hip prosthesis combined with impaction allografting.

Between 1999 and 2002, we revised 72 hips in 69 patients using this technique (mean age 65years). Indications were aseptic loosening (56), infection (8), peri-prosthetic fracture (7) and a broken stem (1). The mean time to revision was 8.5 years (1–21years). Patients were assessed clinically and with the Oxford Hip Score (OHS) pre- and post-operatively. Fifty-seven patients also had acetabular revision. Four patients required femoral osteotomy to remove the old prosthesis. We used a mean of 1.8 (1–4) femoral heads per operation.

Patients were mobilised partially weight bearing (8weeks) followed by a gradual return to full loading. Complications included peri-operative femoral fracture (6), infection (6), dislocation (10), DVT (1)and PE (2). The average blood transfusion was 1.8 units (0–9). The OHS improved from 45 (26–58) pre-operatively to 24.3 post-operatively (12–43). No hip has been re-revised for aseptic loosening at a mean follow-up of 32.7months (16–51).

The Oxford hip is a trimodular prosthesis with a polished tapered metaphyseal section that is free to slide and rotate on the stem. The stem is first inserted uncemented into the diaphysis. Bone graft is impacted proximally, with mesh if necessary, and then the proximal wedge is cemented in. The wedge allows for some subsidence in the cement and creates optimal radial force transmission, which is essential for bone-remodelling stimulation and preventing proximal stress shielding. Although this is a short-term experience, we believe that the use of the tri-modular Oxford stem combined with minimal proximal impaction allografting is a reliable method of dealing with difficult revision femoral surgery. The results were comparable with a primary arthroplasty in terms of pain relief and functional results.

The Charnley Elite femoral component was first introduced in 1992 as a new design variant of the original Charnley femoral component (De Puy, Leeds, UK) with modified neck and stem geometry. The original component had undergone few changes in nearly forty years and has excellent long-term results. Early migration of the new stem design was determined by Roentgen Stereophotogrammetric Analysis (RSA)1. Rapid early migration of a component relative to the bone, measured by RSA, is predictive of subsequent aseptic loosening for a number of femoral stems. As there was rapid early migration and rotation of the Charnley Elite stem, we predicted that the long-term results would be poor. An outcome assessment is indicated as stems of this type are still being implanted.

One hundred Charnley Elite stems, implanted in our centre between 1994 and 1997 were included in a prospective, cross-sectional follow-up study. Outcome measures include validated clinical scores (Charnley hip score, Harris hip score and Oxford hip score) and radiological scores (Gruen classification) as well as revision rates over the past 10 years.

The clinical follow-up supports the RSA predictions of early failure of the Charnley Elite femoral stem.

Oxford Unicompartmental knee arthroplasty (UKA) is now performed using a minimally invasive surgical (MIS) technique. Although early results are encouraging, the studies assessing outcome could be criticised for the restricted number of patients and limited follow-up. Aim of this study was to assess clinical outcome and prosthetic survival rate inpatients with minimally invasive Oxford medial UKA.

This prospective study assessed 500 consecutive patients, who underwent cemented Oxford UKA for medial OA using MIS technique. Patients were assessed using objective and functional Knee Society Score (KSS).

This study has confirmed preliminary findings that Oxford UKA using a minimally invasive approach is safe, reliable and effective.

Aim: To investigate the functional and radiological outcome of shelf acetabuloplasty in adults with significantly symptomatic acetabular dysplasia, with a minimum of a 5 year follow-up.

Material and Methods: 77 consecutive shelf procedures (68 patients) with an average follow-up of 10.9 years (range: 6–14) were reviewed. The Oxford hip score (OHS) was used for clinical assessment. Centre-edge angle (CEA) and acetabular angle (AA) were measured as indicators of joint containment. The severity of osteoarthiritis was based primarily on the extent of joint space narrowing. Survivorship analyses using conversion to THR as an endpoint were performed. Logrank tests were used to compare the survivorship of the shelf procedure against the variables of age, preoperative osteoarthiritis, pre and postoperative AA, CEA angles.

Results: The average age at time of surgery was 33 years (range: 17–60). At the time of the last follow-up, the mean OHS was 34.6 (maximum score: 48). Mean postoperative CEA was 55 (Pre-operatively: 13 degrees) while mean postoperative AA was 31 (Pre-operatively: 48 degrees). Thirty percent of hips needed THR at an average duration of 7.3 years. The survival in the 45 patients with only slight or no joint space narrowing was 97% (CI, 93%–100%) at 5 years and 80% (CI, 56%–100%) at 10 years. This was significantly higher (p= 0.0007) than the survival in the 32 patients with moderate or severe osteoarthiritis, which was 72% (CI, 55%–89%) at 5 years and 29% (CI, 13%–45%) at 10 years. There was no significant relationship between survival and age, pre and postoperative AA, CEA angles (p> 0.05).

Conclusion: Shelf-acetabuloplasty offers symptomatic relief to adults with acetabular dysplasia but overall deteriorates with time. About 50% of the patients do not need THR for over 10 years. Best results with shelf-acetabuloplasty were achieved in patients with slight or no joint narrowing.

Introduction: The design philosophy of polished tapered THR stems, such as the Exeter, intend for them to migrate distally within the cement mantle. In addition it is likely that micromotion occurs as a result of functional activity. The pattern of induced stresses will be a function of stem geometry & surface finish, as well as applied loading. Aim: To investigate the stresses induced in the cement mantle of a polished tapered THR stem during functional activity.

Method: Using Roentgen Stereophotogrammetric Analysis (RSA) dynamically induced micro-motion (DIMM) was measured in 21 patients implanted with Exeter stems. DIMM was measured as the difference in stem position in going from double to single leg stance on the operated limb. All subjects were measured 3 months post-operatively. A finite element (FE) model of the femur, including all muscles was used to investigate the stress distribution within the cement; contact was modelled with sliding elements allowing separation. The model was validated by comparison to the DIMM measurements.

Results: The Exeter stem demonstrated significant DIMM(p < 0.017), the average motions are given in the table below. The FE model, with sliding contacts was able to predict similar distal migration of the head. The peak minimum principal stress in the mantle was approx 33MPa and occurred in the proximal medial region. Movements occurred at the stem/cement interface.

Discussion and Conclusion: It is possible to measure DIMM in the Exeter stem and combining this with FE modelling the mechanism of stress transfer between the stem and mantle can be investigated in a manner that can be validated.

Purpose This study aims to investigate blood flow in the femoral head during Metal-on-Metal Hip Resurfacing (MMHR) through the posterior approach by monitoring oxygen concentration during the operative procedure.

Methods Following division of fascia lata, a calibrated gas-measuring electrode was inserted into the femoral neck, aiming for the anterolateral quadrant of the head. Baseline oxygen concentration levels were detected after electrode insertion 2–3cm below the femoral head surface and all intra-operative measures were referenced against these. Oxygen levels were continuously monitored throughout the operation. Results of measurements from ten patients are presented.

Results Oxygen concentration was reduced during the surgical approach and average oxygen concentration following dislocation and circumferential capsulotomy dropped to 43% of baseline (Std.dev +/−37%), this was a highly significant reduction (p< 0.005). Insertion of implants resulted in a further significant drop in oxygen concentration (p< 0.02) to 16% of baseline (Std. dev +/−27%). Oxygen concentration rose slightly after relocation of the resurfaced joint and reconstruction of posterior soft tissues, reaching 22% (Std.dev +/−31%) of initial baseline oxygen levels. Considerable variation between subjects was observed. Three subjects had no remaining oxygen concentration at the end of surgery.

Conclusion Intra-operative measurement of oxygen concentration in blood perfusing the femoral head is feasible. During MMHR there is a dramatic decrease in femoral oxygenation during surgical approach and implant fixation. This may increase the risk of avascular necrosis and subsequent femoral neck fracture. Future experiments will determine if less invasive procedures or a different approach can protect the blood supply to femoral neck and head.

Introduction Polyethylene wear debris is an important cause of failure in cemented total hip arthroplasty. As a result of the biological response to debris at the bone-cement interface, osteolysis and subsequent failure occurs in both femoral and acetabular components. Most acetabular components and liners are made of ultra high molecular weight polyethylene (UHMWPE). Cross-linking UHMWPE has been shown to significantly reduce abrasive wear in hip simulator studies. The wear rates measured in vitro do not always correlate with the wear rates measured in clinical studies[1]. Some new polyethylenes have shown catastrophic wear in clinical studies despite encouraging hip simulator study results[2]. The aim of this study was to compare the wear of standard UHMWPE to that of cross-linked UHMWPE (Longevity, Zimmer, Warsaw, USA)

Patients and Methods This was a prospective, double blind, randomised control trial. 50 subjects were recruited, all of whom received the cemented CPT stem and uncemented Trilogy liner (Zimmer, UK). Subjects were randomised to receive either a standard Trilogy liner or a Longevity liner at the time of operation. Both liners are identical in appearance. All liners were of a neutral configuration. RSA was used to measure linear wear. This was calculated by measuring the distance between the centre of the femoral head and the centre of the acetabular liner. The preliminary results of the study are presented.

Results Both groups underwent significant wear over two years. The two year linear wear of the cross-linked UHMWPE was 0.3mm (+/− 0.06mm, p< 0.001). The two year linear wear of the standard UHMWPE was 0.39mm (+/− 0.04mm, p< 0.001). No significant difference existed between the two groups (p=0.24). Both cohorts had around 0.15 to 0.2 mm of measured wear per year. Cross-linked UHMWPE therefore underwent less wear than standard UHMWPE at two years, however this difference was not statistically significant.

Discussion This study suggests that Longevity UHMWPE has similar wear properties to standard UHMWPE in the first two years following implantation. This does not correlate with in vitro hip simulator studies of Longevity polyethylene, which show a significantly lower wear rate than standard UHMWPE. It suggests that hip simulator studies may be of little value in predicting in vivo wear rates and that all new types of polyethylene should be evaluated clinically and radiologically prior to general release. Whether both cohorts continue to wear at similar rates will only be revealed through continued observation.

Introduction Metal-on-Metal Hip Resurfacing (MMHR) has been established as a successful alternative to Total Hip Replacement (THR). However, several series report a 2 % incidence of early femoral neck fractures. Avascular necrosis (AVN) was considered to be responsible for the majority of observed fractures, raising concerns about the femoral head blood supply during MMHR. This study aims to further understand the mechanisms of femoral blood flow restriction by monitoring gas levels (O2) during the operative procedure.

Methods Patients undergoing MMHR using the posterior approach were evaluated. Following division of fascia lata, a guide wire was introduced up the femoral neck, aiming for the anterosuperior quadrant of the head. It was then removed. A calibrated gas-measuring electrode was inserted in the created bone channel. X-ray confirmation was obtained to ensure that the active measurement area of the electrode was 2–3cm below the femoral surface. O2 and N2O levels were then continuously monitored throughout the operation.

Results A preliminary analysis of four patients is presented: Stable N2O- measurements throughout the procedure confirmed valid electrode measurements. Baseline oxygen concentration levels of 40%– 60% were detected before division of short rotators. After hip dislocation oxygen concentration dropped in all patients to levels ranging between 0% and 5%. Oxygen concentration was found to remain depressed at these levels throughout the entire operation in three patients. Recovery of O2 concentration to baseline levels was observed in one patient 15 minutes after dislocation.

Discussion In three patients the extended posterior approach and joint dislocation had a dramatic effect on the perfusion in the femoral head. These patients have a high risk for development of AVN and potential femoral neck fracture. Whilst the results require further verification, subsequent experiments will determine if less invasive procedures or specific positioning of the limb can protect the femoral blood supply.

Introduction: The Charnley Elite femoral component was first introduced in 1992 as a new design variant of the original Charnley femoral component (De Puy, Leeds, UK) with modified neck and stem geometry. The original component had undergone few changes in nearly forty years and has excellent long-term results.

Early migration of the new stem design was determined by Roentgen Stereophotogrammetric Analysis (RSA). Rapid early migration of a component relative to the bone, measured by RSA, is predictive of subsequent aseptic loosening for a number of femoral stems. As there was rapid early migration and rotation of the Charnley Elite stem, we predicted that the long-term results would be poor. An outcome assessment is required as stems of this type are still being implanted.

Materials and method: One hundred Charnley Elite stems, implanted in our centre between 1994 and 1997 were included in a prospective, cross-sectional follow-up study. Outcome measures include validated clinical scores (Charnley hip score, Harris hip score and Oxford hip score) and radiological scores (Gruen classification) as well as revision rates over the past 10 years.

Results: The preliminary analysis results are given. The mean time to follow-up was 8.28 years. 20 patients have died due to causes unrelated to their operations. 10 patients had stem revisions: 9 for aseptic loosening and 1 for a peri-prosthetic fracture. This indicates a significant 10% failure rate of the prosthesis in less than 10 years.

Preliminary clinical scores in the patients who had not undergone any subsequent surgery were adequate (Oxford Hip Score mean average of 23.9).

Thirteen percent of radiographs analysed had evidence of loosening, giving an overall loosening rate of 14% at 8 years.

Discussion and conclusion: The clinical follow-up supports the RSA predictions of early failure of the Charnley Elite femoral stem.

Background: Hip dysplasia is a complex developmental process. Untreated acetabular dysplasia is the most common cause of secondary hip osteoarthiritis. With increased interest in redirectional pelvic osteotomies, the role of the shelf procedure needs to be re-defined.

Aim of the study: to investigate the effectiveness of the shelf procedure in adults with symptomatic acetabular dysplasia by assessing the functional and radiological outcome at a minimum of five years follow-up.

Material and Methods: Seventy-six consecutive adults with symptomatic acetabular dysplasia treated with acetabular shelf augmentation, have been followed up for an average period of 11 years (range: 6–14). The mean age was thirty-three years (range: 17–60 years). The Oxford hip score (OHS) was used for clinical assessment. Centre-edge angle (CEA) and acetabular angle (AA) were measured to determine femoral head coverage. Osteoarthiritis severity was based primarily on the width of the joint space using the De Mourgues classification. Survivorship analyses using conversion to THR as an endpoint were performed. logrank test was used to compare the outcome of the shelf against the variables of age, preoperative osteoarthiritis, preoperative and postoperative AA, CEA angles.

Results: The shelf procedure improved the mean preoperative CEA from 11° (range: 20° to 17°) to 50° postoperatively (range: 30° to 70°) and the mean preoperative AA from 52° (range: 46° to 64°) to 32° postoperatively (range: 18° to 57°). The Mean OHS was 34.6 (hip score maximum: 48). Thirty percent of hips needed THR at an average duration of 7.3 years. Survival analysis using conversion to THR as an endpoint was 86% (CI, 76%–95%) at five years and 46% (CI, 27%–65%) at ten years. The survival in the 44 patients with only slight or no joint space narrowing was 97% (CI, 93%–100%) at 5 years and 75% (CI, 51%–100%) at 10 years. This was significantly higher (p= 0.0007) than the survival in the 32 patients with moderate or severe osteoarthiritis, which was 76% (CI, 55%–89%) at 5 years and 22% (CI, 5%–38%) at 10 years. There was no significant relationship between survival and age (p= 0.37), pre and postoperative centre-edge angle (p= 0.39), or acetabular angle (p= 0.85).

Conclusion: Shelf acetabuloplasty is a reliable, safe procedure offering medium-term symptomatic relief for adults with acetabular dysplasia. The best results were achieved in patients with slight or no joint space narrowing.

We inserted an electrode up the femoral neck into the femoral head of ten patients undergoing a metal-on-metal hip resurfacing arthroplasty through a posterior surgical approach and measured the oxygen concentration during the operation. In every patient the blood flow was compromised during surgery, but the extent varied. In three patients, the oxygen concentration was zero at the end of the procedure. The surgical approach caused a mean 60% drop (p < 0.005) in oxygen concentration while component insertion led to a further 20% drop (p < 0.04). The oxygen concentration did not improve significantly on wound closure. This study demonstrates that during hip resurfacing arthroplasty, patients experience some compromise to their femoral head blood supply and some have complete disruption.

We followed up 76 consecutive hips with symptomatic acetabular dysplasia treated by acetabular shelf augmentation for a mean period of 11 years. Survival analysis using conversion to hip replacement as an end-point was 86% at five years and 46% at ten years. Forty-four hips with slight or no narrowing of the joint space pre-operatively had a survival of 97% at five and 75% at ten years. This was significantly higher (p = 0.0007) than that of the 32 hips with moderate or severe narrowing of the joint-space, which was 76% at five and 22% at ten years. There was no significant relationship between survival and age (p = 0.37) or the pre- and post-operative centre-edge (p = 0.39) and acetabular angles (p = 0.85).

Shelf acetabuloplasty is a reliable, safe procedure offering medium-term symptomatic relief for adults with acetabular dysplasia. The best results were achieved in patients with mild and moderate dysplasia of the hip with little arthritis.

Introduction: The Birmingham Hip Resurfacing (BHR) is a metal on metal prosthesis with no published independent clinical studies. It is increasingly used as an alternative to stemmed prostheses in younger patients.

This study presents the 2 year migration results of the BHR femoral component using Roentgen Stereophoto-grammteric Analysis (RSA).

Methods: 26 hips in 24 subjects underwent a BHR, through the postero-lateral approach using CMW3G cement. RSA marker balls were placed in the cortical bone of the femur intra-operatively. The femoral component migration was measured at intervals of 3, 6, 12 and 24 months postoperatively using the Oxford RSA system. The implants were un-modified, geometric algorithms were used to identify the femoral component.

Results: The BHR femoral component showed no significant displacement from its immediate post-operative position. All components of migration showed no significant displacement in any direction, at 1 or 2 years.

Conclusion: The BHR femoral component does not migrate significantly within the first two post-operative years. Its’ migration compares favourably to other designs of femoral component. The BHR is therefore likely to remain stable in the future, as the majority of implant migration occurs within the first two years.

Polished, tapered stems are now widely used for cemented total hip replacement and many such designs have been introduced. However, a change in stem geometry may have a profound influence on stability. Stems with a wide, rectangular proximal section may be more stable than those which are narrower proximally. We examined the influence of proximal geometry on stability by comparing the two-year migration of the Exeter stem with a more recent design, the CPS-Plus, which has a wider shoulder and a more rectangular cross-section. The hypothesis was that these design features would increase rotational stability.

Both stems subsided approximately 1 mm relative to the femur during the first two years after implantation. The Exeter stem was found to rotate into valgus (mean 0.2°, sd 0.42°) and internally rotate (mean 1.28°, sd 0.99°). The CPS-Plus showed no significant valgus rotation (mean 0.2°, sd 0.42°) or internal rotation (mean −0.03°, sd 0.75°). A wider, more rectangular cross-section improves rotational stability and may have a better long-term outcome.

We describe a technique of ‘cross-hip distraction’ to reduce a dislocated hip with subsequent reconstruction of the joint for septic arthritis with extensive femoral osteomyelitis. A 27-year-old woman presented with a dislocated, collapsed femoral head and chronic osteomyelitis of the femur. Examination revealed a leg-length discrepancy of 7 cm and an irritable hip. A staged technique was used with primary clearance of osteomyelitis and secondary reconstruction of the hip. A cross-hip monolateral external fixator was used to establish normal anatomy followed by an arthroplasty. A good functional outcome was achieved. The use of cross-hip distraction avoids soft-tissue and nerve damage and achieved improved abductor function before arthroplasty.

We present the histological findings of bone retrieved from beneath the femoral components of failed metal-on-metal hip resurfacing arthroplasties. Of a total of 377 patients who underwent resurfacing arthroplasty, 13 required revision; for fracture of the femoral neck in eight, loosening of a component in three and for other reasons in two. None of these cases had shown histological evidence of osteonecrosis in the femoral bone at the time of the initial implantation.

Bone from the remnant of the femoral head showed changes of osteonecrosis in all but one case at revision. In two cases of fracture which occurred within a week of implantation, the changes were compatible with early necrosis of the edge of the fracture. In the remaining six fractures, there were changes of established osteonecrosis. In all but one of the non-fracture cases, patchy osteonecrosis was seen.

We conclude that histological evidence of osteonecrosis is a common finding in failed resurfaced hips. Given that osteonecrosis is extensive in resurfaced femoral heads which fail by fracture, it is likely to play a role in the causation of these fractures.

Aim: To investigate the functional and radiological outcome of shelf acetabuloplasty in adults with significantly symptomatic acetabular dysplasia, with a minimum of a 5 year follow-up.

Material and Methods: 77 consecutive shelf procedures (68 patients) with an average follow-up of 10.9 years (range: 6–17) were reviewed. The Oxford hip score (OHS) was used for clinical assessment. Centre-edge angle (CEA) and acetabular angle (AA) were measured as indicators of joint containment. The severity of osteoarthiritis was based primarily on the extent of joint space narrowing. Survivorship analyses using conversion to THR as an endpoint were performed. Logrank tests were used to compare the survivorship of the shelf procedure against the variables of age, preoperative osteoarthiritis, pre and postoperative AA, CEA angles.

Results: The average age at time of surgery was 33 years (range: 17–60). At the time of the last follow-up, the mean OHS was 34.6 (maximum score: 48). Mean postoperative CEA was 55 (Pre-operatively: 13 degrees) while mean postoperative AA was 31 (Pre-operatively: 48 degrees). Thirty percent of hips needed THR at an average duration of 7.3 years. The survival in the 45 patients with only slight or no joint space narrowing was 97% (CI, 93%-100%) at 5 years and 75% (CI, 51%-100%) at 10 years. This was significantly higher (p≤= 0.0007) than the survival in the 32 patients with moderate or severe osteoarthiritis, which was 76% (CI, 55%-89%) at 5 years and 22% (CI, 5%-38%) at 10 years. There was no significant relationship between survival and age, pre and postoperative AA, CEA angles (p> 0.05).

Conclusion: Shelf-acetabuloplasty offers symptomatic relief to adults with acetabular dysplasia but overall deteriorates with time. About 50% of the patients do not need THR for over 10 years. Best results with shelf-acetabuloplasty were achieved in patients with slight or no joint narrowing.

Purpose of the study: To evaluate the clinical outcome of revision total hip arthroplasty (THA) using the Oxford Hip prosthesis combined with impaction allografting. Methods and results: The Oxford hip is a trimodular prosthesis with a polished tapered metaphyseal section that is free to slide on the stem. The stem is inserted uncemented into the diaphysis, bone graft is impacted proximally, with mesh if necessary, and then the proximal wedge is cemented in.

Between 1999 and 2002, we revised 72 hips in 69 patients using this technique (mean age 65years, 28 to 88). Fifty-six cases had aseptic loosening, 8 had infection (2 stages), 7 had peri-prosthetic fractures and 1 had a broken stem. The mean time to revision was 8.5years (1 to 21). Patients were assessed clinically and with the Oxford Hip Score (OHS) pre- and post-operatively. Fifty-seven patients also had acetabular revision. Four patients required femoral osteotomy to remove the old prosthesis. We used a mean of 1.8 (1 to 4) femoral heads per operation.

Complications included 6 peri-operative femoral fractures diagnosed at operation and fixed successfully, 6 infections, 10 dislocations (2 were recurrent), one deep vein thrombosis, 2 pulmonary embolism and one gastrointestinal haemorrhage. The average blood transfusion was 1.8 units (0 to 9).

The OHS improved from 45 (26 to 58) pre-operatively to 24.3 post-operatively (12 to 43). No hip has been re-revised for aseptic loosening at a mean follow-up of 32.7 months (16 to 51).

Conclusion: Although we accept that this is only a preliminary experience, we believe that the use of the trimodular Oxford stem combined with minimal proximal impaction allografting was found to be a reliable method and a successful way of dealing with revision femoral surgery. The results were comparable with a primary arthroplasty in terms of pain relief and functional results

There is an increasing interest amongst surgeons and demand from patients for hip resurfacing. One concern regarding resurfacing is the incidence of femoral neck fracture post operatively. McMinn and Treacy report an incidence of 0.4% in their series, our finding was of an incidence of over four times as high (1.9%). We looked at our database of hip resurfacings and tried to identify the risk factors for fracture.

We identified 11 fractures and compared these with 22 controls selected by choosing the cases performed by the surgeon immediately before and after the fracture case. We analysed their medical notes and x-rays. Statistical analysis was performed using a package in ™Excel. The implants were either Birmingham Hip (Midland Medical Technologies) or Cormet (Corin) resurfacings.

No statistically significant correlation was found for sex, age or body mass index. We found that fracture was twice as likely in the presence of possible or probable osteopenia. We did not find that fracture was more likely to occur in patients with a previous diagnosis of Perthes, DDH, SUFE and avascular necrosis (AVN).

We found patients with a superior overhang of the femoral component on the neck did not risk fracture, however we could not demonstrate that notching in itself increased the risk of fracture.

There was no correlation with neck-shaft and stem-shaft angle or neck lengthening and offset and subsequent neck fracture.

In 13 bilateral cases there was fracture in 3 (incidence 23%). Apart from one fracture that occurred at 18 weeks post-operatively all the others occurred before eight weeks. Five fractures occurred in patients who subsequently on histological analysis were found to have avascular necrosis.

We conclude that bilateral surgery is probably unwise. That a superior overhang seems to protect against fracture as long as this is not at the expense of creating an inferior notch. Finally, we find AVN in a number of retrieved heads, what is the true incidence of AVN and does the approach adopted cause the avascular process and if so why do we see so few fractures?

Introduction: A new procedure has been recently adopted to implant the Oxford medial unicompartmental arthroplasty (UCA). All cases are now implanted through a short incision without dislocation of the patella. The aims of this study were to assess the one-year results using this new technique and to determine if the outcome is dependent on surgical experience.

Method: The first 104 Oxford UCA’s (Phase 3) implanted by six surgeons under the care of two consultants were reviewed at one year. All operations were performed using the new technique. The average age at surgery was 68 years. All knees were scored pre-operatively and at review with the American Knee Society score. The cohort was divided into two groups; the first ten cases for each surgeon were included in a ‘learning’ group, whilst the remaining cases were included in an ‘experienced’ group.

Results: Overall the average ‘knee score’ improved from 37 points to 94 and the average ‘functional score’ from 50 points to 92. Average maximum flexion improved from 117° to 131°. The ‘knee score’ for the ‘learning’ group was 91 points. This was significantly less (p = 0.008) than the score of the ‘experienced’ group (96 points).

Conclusions: These results are significantly better than the best historical results of the Oxford (UCA), performed through an open approach with dislocation of the patella.

Despite impressive overall results at one year, lower knee scores were associated with a surgeons ‘learning curve’. After this ‘learning curve’, increased surgical experience led to further improvement with 90% achieving an excellent result, 8% a good, 2% a fair and 0% a poor result.

Polyethylene wear remains an important cause of failure in knee replacements. Retrieval studies, simulators and simple X-ray methods produce wear data that may be inaccurate or unrealistic. We have developed an accurate RSA system for measuring wear in-vivo. Using this system we have found wear rate in a fixed bearing TKR to be about 0.1mm/yr[1]. In this abstract we extend the study to fully congruent mobile bearings.

Four Oxford uni-compartmental knee replacements, with excellent clinical results were studied ten years after implantation. RSA X-rays were taken in double leg stance with the knee in full extension and 15 and 30 degrees flexion. Following RSA calibration, silhouettes of the components on the stereo X-rays were extracted using a Canny edge detector and were matched to silhouettes projected using CAD models to determine the 3D component position. The average minimum thickness of the bearing was determined and was compared with the measured minimum thickness of 14 unused bearings to calculate linear penetration.

The average linear penetration after average 10 years implantation (range 8.5 to 10.25 years) was 0.16 mm (SD 0.13 mm). The average penetration rate was 0.017 mm/year (SD 0.011 mm/year). The maximum linear penetration rate was 0.027 mm/year.

The penetration rate is similar to that obtained in a retrieval study [2]. Compression of the bearing is minimal due to 6sqcm of contact area. This study therefore demonstrates that polyethylene wear on the upper and lower surfaces is minimal in fully congruous mobile bearing knee replacements.

Aim: Small amounts of subsidence may be beneficial in stabilising a stem & appears to be a featue of polished tapered stems. Stem rotation (measured as posterior head migration) within the cement mantle, however, is probably a more important mechanism of failure than subsidence. Stems with a wider proximal portion are thought to better resist rotation. The CPS (Endoplus, UK) is such a device; here we compare its’ stability with that of the Exeter (Stryker-Howmedica, UK). Method: 20 patients received the CPS-plus stem & underwent RSA examinations at 3, 6 & 12 months postoperatively. The Exeter 1 year migration data (32 hips) was used as a comparison. Both groups underwent a Hardinge approach & the prosthesis was secured with CMW3G cement. Results: Both stems subsided about 1mm. The CPS showed less medio-lateral & A-P movement of the proximal stem than the Exeter over 1 year, as shown below: 1 Year Mean Migration ± SEM (mm) Discussion: The CPS internally rotates less than the Exeter, as demonstrated by the smaller amount of posterior head migration. It has a lateral flare of the shoulder; making its’ cross-section wider than the Exeter’s, this probably produces a greater resistance to rotation. The CPS also undergoes less medio-lateral proximal stem migration. Its’ lateral shoulder flare is probably responsible for this axial subsidence, as it prevents the shoulder from moving laterally whilst subsiding onto the calcar.

Increasing the width of the proximal section of a polished tapered stem enhances its rotational stability.

Aims: To determine the pathological changes in the femur following resurfacing hip arthroplasty and identify possible causes of early failure. Methods: Bone samples from 8 femoral heads at several levels were examined histologically following removal of cemented femoral head surface replacement following aseptic early failure: 4 neck fractures (no history of fall), 3 persistent severe pain and 1 cup loosening. Intra-operatively no obvious macroscopic causes of failure (including notching the neck) were noted. In all patients, the initial diagnosis had been osteoarthritis. None had known risk factors for osteonecrosis. Results: In the patients who had recent fracture, the bony changes were suggestive of relatively longstanding osteonecrosis with degenerative, necrotic and þbrotic changes in the bone marrow and loss of osteocyte nuclei in the trabeculae. There was appositional new bone formation at the surface of the necrotic bone trabeculae. The changes were consistent with osteonecrosis of more than 2 weeks duration and probably preceded the fracture in all cases. In the patients who underwent revision for non-fracture, some osteonecrosis was seen, but this was a lot less than when a fracture had occurred. Conclusion: Osteonecrosis of the femoral head is seen following resurfacing hip arthroplasty and may be a predisposing factor in patients who subsequently fracture.

The Birmingham hip resurfacing (BHR) arthroplasty is a metal-on-metal prosthesis for which no medium- or long-term results have been published. Despite this, it is increasing in popularity as an alternative to stemmed prostheses for younger patients. Since the fixation of the socket is conventional, the major concern is long-term failure of the femoral component. This can be predicted by the use of roentgen stereophotogrammetric analysis (RSA). We have therefore undertaken such a study of the BHR femoral component over a period of two years.

Twenty patients (22 hips) underwent a standard BHR procedure. Migration of the femoral component was measured by RSA at intervals of three, six, 12 and 24 months. At 24 months the total three-dimensional migration of the head was 0.2 mm. This was not statistically significant. Previous studies have shown that implants which loosen quickly have rapid early migration. Our results therefore suggest that the BHR femoral component is an inherently stable device which is likely to perform well in the long term.

Introduction: Persistent acetabular dysplasia is a recognized cause of premature hip arthritis. Treatment options include joint preservation (acetabuloplasty/osteotomy) or salvage procedures (THR). Presence of a deficient acetabulum and an elevated acetabular centre make THR technically demanding with uncertain outcome. Shelf ace-tabuloplasty is a viable option, however, most reports in the literature focus on results in children and adolescents.

Aim: To investigate the functional and radiological outcome of shelf acetabuloplasty in adults with significantly symptomatic acetabular dysplasia.

Material and Methods: 77 consecutive shelf procedures (68 patients) with an average follow-up of 10.9 years (range: 6–17) were reviewed. The Oxford hip score (OHS) was used for clinical assessment. Centre-edge angle (CEA) and acetabular angle (AA) were measured as indicators of joint containment.

Results: The average age at surgery was 33 years (range: 17–60). At the time of last follow-up; the mean OHS was 34 (maximum score: 48). Mean postoperative CEA was 59 (Pre-operatively: 16.2 degrees) while mean postoperative AA was 31 (Pre-operatively: 47.5 degrees). Thirty percent of hips needed THR at an average duration of 7.3 years. Pre-operative arthritis was present in 32 hips out of which 17 (53 percent) needed THR. Out of the remaining 45 hips, only 6 (13 percent) needed THR. No correlation was found between the acetabular indices and the outcome.

Conclusion: Shelf-acetabuloplasty offers symptomatic relief to adults with acetabular dysplasia and can delay the need for THR for over 10 years. Best results with shelf-acetabuloplasty were achieved in patients without preoperative arthritis.

The relative motion between a prosthesis, the cement mantle and its’ host bone during weight bearing is not well understood. Using Radiostereophotogrammetric Analysis (RSA), we examined the dynamically inducible micromotion that exists at these interfaces when an increased load is placed through the prosthesis.

Dynamically inducible micromotion was measured in the femoral components of 21 subjects undergoing total hip replacement with polished Exeter stems. Two standing RSA studies were performed, at 3 and 12 months postoperatively. Firstly in double-leg stance, and secondly fully weight bearing through the operated hip.

Subjects had no signs of clinical or radiological signs of loosening at 1 year. Significant micromotion was detected at the prosthesis-cement interface at 3 months.

Similar patterns of micromotion were observed at 12 months. The prosthesis appeared to bend during single-leg stance weight bearing, however this accounted for less than half of the total observed movement.

Conventional RSA studies were conducted at 3 months, 6 months and 1 year to confirm that the implants showed normal migration patterns.

This study demonstrates that movement exists between the prosthesis and bone during cyclical weight bearing. This dynamically inducible micromotion probably occurs at the prosthesis-cement interface. It could account for the wear that is observed on the surface of retrieved secure prostheses. This may be a mechanism by which failure eventually occurs.

The aim of the study was to measure in-vivo the 10-year linear and volumetric polyethylene wear of a fully congruent mobile bearing unicompartmental knee arthroplasty (OUKA).

We studied six OUKA’s that had all been implanted 10 years previously. Each patient was examined in even double leg stance at a range of knee flexion angles, in a calibration cage. A stereo pair of X-ray films was acquired for each patient at 0°, 15° and 30° of flexion. The films were analysed using an RSA style calibration and a CAD model silhouette-fitting technique. The position and orientation of each femoral and tibial component was found relative to each other and the bearing position inferred. Penetration of the femoral component into the original volume of the bearing was our estimate of linear wear. The volumetric wear is calculated from the measured linear wear and the known surface area of the bearing. In addition eight control patients were examined less than 3 weeks post-operation where no wear would be expected.and 30We studied seven OUKA’s that had all been implanted at least 10 years previously. A stereo pair of X-ray films was acquired for each patient at 0 Results: The control group showed no measured wear. The seven OUKA’s had an average maximum depth of linear penetration of 0.40 mm at a mean follow-up of 10.9 years. The linear wear rate was 0.033 mm/year. The volumetric material loss was 79.8 mm3. If a steady gradual material loss is assumed, 8 mm3 of UHMWPE was lost per year.

Polyethylene particulate wear debris continues to be implicated in the aetiology of component loosening and implant failure knee following arthroplasty. The OUKA employs a spherical femoral component and a fully congruous meniscal bearing to increase contact area and theoretically reduce the potential for polyethylene wear. The results from this in-vivo study confirm that the device has low 10-year linear and volumetric wear in clinical practice. This may protect the device from component loosening in the long term.

The Birmingham reSurfacing Arthroplasty (BSA) is a metal on metal prosthesis with no published independent clinical studies. Despite this, it is increasing in popularity, especially as an alternative to stemmed prostheses in younger patients. This study presents the 1year migration results of the BSA femoral component using Roentgen Stereophotogrammteric Analysis (RSA).

Twenty six subjects underwent a BSA, through the postero-lateral approach using CMW3G cement, with RSA marker balls placed intra-operatively. The femoral component migration was measured at intervals of 3, 6 and 12 months using the Oxford RSA system. Geometric algorhythms were used to identify the femoral component. The data was examined for distribution prior to analysis. All statistical analysis was performed using the t-test.

The data was normally distributed. The 1 year migration results of the BSA femoral component are displayed below.

All cemented implants migrate in vivo. The majority of cemented stemmed implant migration occurs within the first post-operative year. High rates of migration within the first post-operative year correlate with premature component failure in some instances. The BSA is a fundamentally different design to most cemented prostheses, despite this we know that very large migrations, those in excess of 2mm/year in any direction are generally regarded as poor indicators of long term outcome. These results suggest that the BSA femoral component is an inherently stable device as it does not migrate significantly within the first post-operative year. Only long-term independent clinical studies and continued RSA follow-up will enable a comprehensive evaluation of the device.

Introduction: The aim of this study was to compare the serum cobalt and chromium levels in patients with Oxford Universal hips and Cenator hips. Both systems are composed of cobalt chromium alloy and have modular cobalt chromium heads, however only the Oxford hip has a sliding mechanism.

Material: The serum levels of chromium and cobalt were measured in 20 patients with Oxford Universal Hip replacement (Group 1). This was compared to the serum levels of chromium and cobalt in 17 patients with Cenator Hip replacement (Group 2) and 20 patients with no implants (Group 3). Patients in Group 1 and 2 were assessed clinically and with plain radiographs. Patients were excluded if there was evidence of loosening, if they had other joint implants or any other known cobalt or chromium implant and if they had impaired renal function. All hip replacements were performed as primary procedures. Specimens were analysed by electrothermal atomization atomic absorption spectrometry.

Results: There was no statistically significant difference in serum cobalt and chromium levels between groups 1 and 2. Patients in groups 1 and 2 had statistically significant higher serum levels of chromium and cobalt than group 3 patients.

Discussion: This study demonstrates that serum levels of chromium and cobalt are elevated in patients with stable hip implants composed of this alloy but not in a normal population. Although it is not known what the long-term effects of chronic low-grade exposure to these ions are, these levels are many order of magnitude below the toxic range. Furthermore, our results show that the Oxford Universal Hip releases no more metal ions into the circulation than an implant without a sliding mechanism.

Before proceeding to longer-term studies, we have studied the early clinical results of a new mobile-bearing total knee prosthesis in comparison with an established fixed-bearing device. Patients requiring bilateral knee replacement consented to have their operations under one anaesthetic using one of each prosthesis. They also agreed to accept the random choice of knee (right or left) and to remain ignorant as to which side had which implant. Outcomes were measured using the American Knee Society Score (AKSS), the Oxford Knee Score (OKS), and determination of the range of movement and pain scores before and at one year after operation.

Preoperatively, there was no systematic difference between the right and left knees. One patient died in the perioperative period and one mobile-bearing prosthesis required early revision for dislocation of the meniscal component.

At one year the mean AKSS, OKS and pain scores for the new device were slightly better (p < 0.025) than those for the fixed-bearing device. There was no difference in the range of movement.

We believe that this is the first controlled, blinded trial to compare early function of a new knee prosthesis with that of a standard implant. It demonstrates a small but significant clinical advantage for the mobile-bearing design.

This early study examines the influence of a wider shoulder on the 1 year migration of a cemented, polished, tapered stem, using RSA.

Polished, tapered stems (PTS) have excellent 10 year survival rates. RSA studies have demonstrated that these devices subside about 1 mm / year. Small amounts of subsidence are beneficial in stabilising a stem. Stem rotation (measured as posterior head migration) within the cement mantle is probably a more important mechanism of failure than subsidence. Stems with a wider proximal portion are thought to better resist rotation. The CPS (Endoplus, UK) is such a device; here we compare its’ stability with that of the Exeter.

20 patients received the CPS-plus stem and underwent RSA examinations at 3, 6 and 12 months postoperatively. The Exeter 1 year migration data was used as a comparison. Both groups underwent a Hardinge approach with CMW3G cement.

Both stems subsided about 1mm. The CPS showed less medio-lateral and A-P movement of the proximal stem than the Exeter over 1 year, as shown below:

The CPS internally rotates less than the Exeter, as demonstrated by the smaller amount of posterior head migration. It has a lateral flare of the shoulder; making its cross-section wider than the Exeter’s, this probably accounts for its’ greater resistance to rotation. The CPS also undergoes less medio-lateral proximal stem migration. Its’ lateral shoulder flare is probably responsible for this axial subsidence, as it prevents the shoulder from moving laterally whilst subsiding over the calcar.

A PTS with a broad proximal section is more stable, this may confer an increased survival advantage.

Purpose: As part of the step-wise introduction of a meniscal-bearing total knee replacement (Oxford TMK) we needed to know, before proceeding to longer term studies, whether its early clinical results were at least as good as those of an established fixed bearing device (AGC).

Material and Methods: With ethical approval, patients requiring bilateral knee replacement for osteoarthritis consented to have the operations under one anaesthetic using one of each prosthesis; to accept random choice of knee; and to remain ignorant which side was which. American Knee Society Scores, Oxford Knee Scores, ROM and pain scores were to be recorded preoperatively and at one year. By January 2001, 40 patients had reached one year and data is available for 36.

Results: Preoperatively there was no difference between the two knees. One patient died in the peri-operative period.

Results at one year (TMK first): AKSS(Knee) 91.6 / 84.1 (p=0.003), OKS 39.8 / 37.6 (p=0.006), ROM 104 / 104 (p=0.364), Pain (AKSS) 47.3 / 41.7 (p=0.01), Pain (OKS) 3.5 / 2.9 (p=0.006).

Conclusion: The TMK performed as well as the AGC. Its AKSS, OKS and pain scores were significantly better. We believe this controlled, blinded trial is the first to have compared the function of a new knee prosthesis with a standard implant before marketing; and the first to have demonstrated a significant clinical advantage for a meniscal-bearing over a fixed bearing TKR. The comparison of bilateral implants in the same patient can reveal significant differences while putting at risk many fewer subjects than would be needed for a classical twocohort RCT.

The Oxford hip score (OHS) is a patient-based instrument for assessment of outcome which is often used after total hip replacement, and the EuroQol 5D (EQ5D) is a patient-based generic questionnaire for health assessment. In an analysis of the outcome at one year of 609 revision hip replacements (RHRs), we compared the OHS and EQ5D scores, postoperative patient satisfaction and change in pain. About 25% of the operations were repeat RHRs. At one year, 57% of patients were very pleased with their operation. The correlation between preoperative and postoperative scores and change scores for the OHS and EQ5D was high. For both instruments the effect sizes were large, but the greater effect size of the OHS suggests that it is particularly sensitive to improvements after RHR. The effect scores of the OHS declined with the number of previous RHRs, while those for the EQ5D seemed less sensitive. Our results confirm the value of the OHS in assessing outcome after RHR.

Ultrasound examination has been recommended for the evaluation of acute haemorrhages into soft tissues or joints in haemophilic patients. We have reviewed the notes of all such patients admitted during one calendar year and find that in 47 separate admissions the ultrasound examination assisted management decisions on 27 occasions. The technique is described with an analysis of the ways in which ultrasound observations may influence the clinician.