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The Bone & Joint Journal
Vol. 106-B, Issue 3 Supple A | Pages 59 - 66
1 Mar 2024
Karunaseelan KJ Nasser R Jeffers JRT Cobb JP

Aims

Surgical approaches that claim to be minimally invasive, such as the direct anterior approach (DAA), are reported to have a clinical advantage, but are technically challenging and may create more injury to the soft-tissues during joint exposure. Our aim was to quantify the effect of soft-tissue releases on the joint torque and femoral mobility during joint exposure for hip resurfacing performed via the DAA.

Methods

Nine fresh-frozen hip joints from five pelvis to mid-tibia cadaveric specimens were approached using the DAA. A custom fixture consisting of a six-axis force/torque sensor and motion sensor was attached to tibial diaphysis to measure manually applied torques and joint angles by the surgeon. Following dislocation, the torques generated to visualize the acetabulum and proximal femur were assessed after sequential release of the joint capsule and short external rotators.


Bone & Joint Open
Vol. 4, Issue 12 | Pages 948 - 956
15 Dec 2023
Vella-Baldacchino M Webb J Selvarajah B Chatha S Davies A Cobb JP Liddle AD

Aims

With up to 40% of patients having patellofemoral joint osteoarthritis (PFJ OA), the two arthroplasty options are to replace solely the patellofemoral joint via patellofemoral arthroplasty (PFA), or the entire knee via total knee arthroplasty (TKA). The aim of this study was to assess postoperative success of second-generation PFAs compared to TKAs for patients treated for PFJ OA using patient-reported outcome measures (PROMs) and domains deemed important by patients following a patient and public involvement meeting.

Methods

MEDLINE, EMBASE via OVID, CINAHL, and EBSCO were searched from inception to January 2022. Any study addressing surgical treatment of primary patellofemoral joint OA using second generation PFA and TKA in patients aged above 18 years with follow-up data of 30 days were included. Studies relating to OA secondary to trauma were excluded. ROB-2 and ROBINS-I bias tools were used.


Bone & Joint Research
Vol. 11, Issue 8 | Pages 575 - 584
17 Aug 2022
Stoddart JC Garner A Tuncer M Cobb JP van Arkel RJ

Aims

The aim of this study was to determine the risk of tibial eminence avulsion intraoperatively for bi-unicondylar knee arthroplasty (Bi-UKA), with consideration of the effect of implant positioning, overstuffing, and sex, compared to the risk for isolated medial unicondylar knee arthroplasty (UKA-M) and bicruciate-retaining total knee arthroplasty (BCR-TKA).

Methods

Two experimentally validated finite element models of tibia were implanted with UKA-M, Bi-UKA, and BCR-TKA. Intraoperative loads were applied through the condyles, anterior cruciate ligament (ACL), medial collateral ligament (MCL), and lateral collateral ligament (LCL), and the risk of fracture (ROF) was evaluated in the spine as the ratio of the 95th percentile maximum principal elastic strains over the tensile yield strain of proximal tibial bone.


Bone & Joint Research
Vol. 11, Issue 5 | Pages 317 - 326
23 May 2022
Edwards TC Guest B Garner A Logishetty K Liddle AD Cobb JP

Aims

This study investigates the use of the metabolic equivalent of task (MET) score in a young hip arthroplasty population, and its ability to capture additional benefit beyond the ceiling effect of conventional patient-reported outcome measures.

Methods

From our electronic database of 751 hip arthroplasty procedures, 221 patients were included. Patients were excluded if they had revision surgery, an alternative hip procedure, or incomplete data either preoperatively or at one-year follow-up. Included patients had a mean age of 59.4 years (SD 11.3) and 54.3% were male, incorporating 117 primary total hip and 104 hip resurfacing arthroplasty operations. Oxford Hip Score (OHS), EuroQol five-dimension questionnaire (EQ-5D), and the MET were recorded preoperatively and at one-year follow-up. The distribution was examined reporting the presence of ceiling and floor effects. Validity was assessed correlating the MET with the other scores using Spearman’s rank correlation coefficient and determining responsiveness. A subgroup of 93 patients scoring 48/48 on the OHS were analyzed by age, sex, BMI, and preoperative MET using the other metrics to determine if differences could be established despite scoring identically on the OHS.


Bone & Joint Research
Vol. 11, Issue 2 | Pages 91 - 101
1 Feb 2022
Munford MJ Stoddart JC Liddle AD Cobb JP Jeffers JRT

Aims

Unicompartmental and total knee arthroplasty (UKA and TKA) are successful treatments for osteoarthritis, but the solid metal implants disrupt the natural distribution of stress and strain which can lead to bone loss over time. This generates problems if the implant needs to be revised. This study investigates whether titanium lattice UKA and TKA implants can maintain natural load transfer in the proximal tibia.

Methods

In a cadaveric model, UKA and TKA procedures were performed on eight fresh-frozen knee specimens, using conventional (solid) and titanium lattice tibial implants. Stress at the bone-implant interfaces were measured and compared to the native knee.


Bone & Joint Research
Vol. 10, Issue 11 | Pages 723 - 733
1 Nov 2021
Garner AJ Dandridge OW Amis AA Cobb JP van Arkel RJ

Aims

Bi-unicondylar arthroplasty (Bi-UKA) is a bone and anterior cruciate ligament (ACL)-preserving alternative to total knee arthroplasty (TKA) when the patellofemoral joint is preserved. The aim of this study is to investigate the clinical outcomes and biomechanics of Bi-UKA.

Methods

Bi-UKA subjects (n = 22) were measured on an instrumented treadmill, using standard gait metrics, at top walking speeds. Age-, sex-, and BMI-matched healthy (n = 24) and primary TKA (n = 22) subjects formed control groups. TKA subjects with preoperative patellofemoral or tricompartmental arthritis or ACL dysfunction were excluded. The Oxford Knee Score (OKS) and EuroQol five-dimension questionnaire (EQ-5D) were compared. Bi-UKA, then TKA, were performed on eight fresh frozen cadaveric knees, to investigate knee extensor efficiency under controlled laboratory conditions, using a repeated measures study design.


Bone & Joint Open
Vol. 2, Issue 8 | Pages 638 - 645
1 Aug 2021
Garner AJ Edwards TC Liddle AD Jones GG Cobb JP

Aims

Joint registries classify all further arthroplasty procedures to a knee with an existing partial arthroplasty as revision surgery, regardless of the actual procedure performed. Relatively minor procedures, including bearing exchanges, are classified in the same way as major operations requiring augments and stems. A new classification system is proposed to acknowledge and describe the detail of these procedures, which has implications for risk, recovery, and health economics.

Methods

Classification categories were proposed by a surgical consensus group, then ranked by patients, according to perceived invasiveness and implications for recovery. In round one, 26 revision cases were classified by the consensus group. Results were tested for inter-rater reliability. In round two, four additional cases were added for clarity. Round three repeated the survey one month later, subject to inter- and intrarater reliability testing. In round four, five additional expert partial knee arthroplasty surgeons were asked to classify the 30 cases according to the proposed revision partial knee classification (RPKC) system.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_4 | Pages 42 - 42
1 Mar 2021
Quarshie R Marway S Logishetty K Keane B Cobb JP
Full Access

Patients undergoing hip resurfacing arthroplasty (HRA) is typically reserved for highly active patients. Patient Reported Outcome Measures (PROMs) such as the Oxford Hip Score (OHS) are reported to have ceiling effects, which may limit physicians' ability to measure health gain in these patients. The Metabolic Equivalent of Task (MET) index is a validated compendium assigning energy expenditure to a wide range of activities; for example, a slow walk expends 2.9 kcal/kg/hour, golf expends 4.0 kcal/kg/hour, while moderate lacrosse typically expends 8.1 kcal/kg/hour. We hypothesized that for patients with high OHS (47–48) after HRA, the MET index could better discriminate between high-performing individuals.

We evaluated 97 consecutive HRA patients performed by a single surgeon. They prospectively completed an online Oxford Hip Score. They also listed three activities which they had performed independently in the preceding 2 weeks with a Likert-scale slider denoting intensity of effort. Matched data-sets were obtained from 51 patients, from which 23 had OHS of 47–48 at 6-months. Their activity with the highest MET index was selected for analysis. The 23 patients' OHS improved from 29.3 ± 7.0 preoperatively to 47.6 ± 0.5 after 6-months, while their MET indices improved from 8.5 ± 3.7 to 12.9 ± 3.5 kcal/kg/hr. The activities performed by these high-performance individuals ranged from the lowest, pilates (8.05 kcal/kg/hour), to highest, running at 22km/hr (23 kcal/kg/hour). 45% of patients undergoing HRA in this cohort had OHS of 47 and 48 at 6-months after surgery.

Unlike the OHS, the MET index described variation in physical activity in these high-performance individuals, and did so on an objective measurable scale.


Bone & Joint Research
Vol. 10, Issue 1 | Pages 1 - 9
1 Jan 2021
Garner A Dandridge O Amis AA Cobb JP van Arkel RJ

Aims

Unicompartmental knee arthroplasty (UKA) and bicompartmental knee arthroplasty (BCA) have been associated with improved functional outcomes compared to total knee arthroplasty (TKA) in suitable patients, although the reason is poorly understood. The aim of this study was to measure how the different arthroplasties affect knee extensor function.

Methods

Extensor function was measured for 16 cadaveric knees and then retested following the different arthroplasties. Eight knees underwent medial UKA then BCA, then posterior-cruciate retaining TKA, and eight underwent the lateral equivalents then TKA. Extensor efficiency was calculated for ranges of knee flexion associated with common activities of daily living. Data were analyzed with repeated measures analysis of variance (α = 0.05).


Bone & Joint 360
Vol. 9, Issue 1 | Pages 4 - 9
1 Feb 2020
Logishetty K Muirhead-Allwood SK Cobb JP


The Bone & Joint Journal
Vol. 101-B, Issue 12 | Pages 1585 - 1592
1 Dec 2019
Logishetty K Rudran B Cobb JP

Aims

Arthroplasty skills need to be acquired safely during training, yet operative experience is increasingly hard to acquire by trainees. Virtual reality (VR) training using headsets and motion-tracked controllers can simulate complex open procedures in a fully immersive operating theatre. The present study aimed to determine if trainees trained using VR perform better than those using conventional preparation for performing total hip arthroplasty (THA).

Patients and Methods

A total of 24 surgical trainees (seven female, 17 male; mean age 29 years (28 to 31)) volunteered to participate in this observer-blinded 1:1 randomized controlled trial. They had no prior experience of anterior approach THA. Of these 24 trainees, 12 completed a six-week VR training programme in a simulation laboratory, while the other 12 received only conventional preparatory materials for learning THA. All trainees then performed a cadaveric THA, assessed independently by two hip surgeons. The primary outcome was technical and non-technical surgical performance measured by a THA-specific procedure-based assessment (PBA). Secondary outcomes were step completion measured by a task-specific checklist, error in acetabular component orientation, and procedure duration.


The Bone & Joint Journal
Vol. 101-B, Issue 11 | Pages 1423 - 1430
1 Nov 2019
Wiik AV Lambkin R Cobb JP

Aims

The aim of this study was to assess the functional gain achieved following hip resurfacing arthroplasty (HRA).

Patients and Methods

A total of 28 patients (23 male, five female; mean age, 56 years (25 to 73)) awaiting Birmingham HRA volunteered for this prospective gait study, with an age-matched control group of 26 healthy adults (16 male, ten female; mean age, 56 years (33 to 84)). The Oxford Hip Score (OHS) and gait analysis using an instrumented treadmill were used preoperatively and more than two years postoperatively to measure the functional change attributable to the intervention.


The Bone & Joint Journal
Vol. 101-B, Issue 4 | Pages 426 - 434
1 Apr 2019
Logishetty K van Arkel RJ Ng KCG Muirhead-Allwood SK Cobb JP Jeffers JRT

Aims

The hip’s capsular ligaments passively restrain extreme range of movement (ROM) by wrapping around the native femoral head/neck. We determined the effect of hip resurfacing arthroplasty (HRA), dual-mobility total hip arthroplasty (DM-THA), conventional THA, and surgical approach on ligament function.

Materials and Methods

Eight paired cadaveric hip joints were skeletonized but retained the hip capsule. Capsular ROM restraint during controlled internal rotation (IR) and external rotation (ER) was measured before and after HRA, DM-THA, and conventional THA, with a posterior (right hips) and anterior capsulotomy (left hips).


Bone & Joint Research
Vol. 7, Issue 8 | Pages 524 - 538
1 Aug 2018
Zhao S Arnold M Ma S Abel RL Cobb JP Hansen U Boughton O

Objectives

The ability to determine human bone stiffness is of clinical relevance in many fields, including bone quality assessment and orthopaedic prosthesis design. Stiffness can be measured using compression testing, an experimental technique commonly used to test bone specimens in vitro. This systematic review aims to determine how best to perform compression testing of human bone.

Methods

A keyword search of all English language articles up until December 2017 of compression testing of bone was undertaken in Medline, Embase, PubMed, and Scopus databases. Studies using bulk tissue, animal tissue, whole bone, or testing techniques other than compression testing were excluded.


Bone & Joint Research
Vol. 6, Issue 9 | Pages 542 - 549
1 Sep 2017
Arnold M Zhao S Ma S Giuliani F Hansen U Cobb JP Abel RL Boughton O

Objectives

Microindentation has the potential to measure the stiffness of an individual patient’s bone. Bone stiffness plays a crucial role in the press-fit stability of orthopaedic implants. Arming surgeons with accurate bone stiffness information may reduce surgical complications including periprosthetic fractures. The question addressed with this systematic review is whether microindentation can accurately measure cortical bone stiffness.

Methods

A systematic review of all English language articles using a keyword search was undertaken using Medline, Embase, PubMed, Scopus and Cochrane databases. Studies that only used nanoindentation, cancellous bone or animal tissue were excluded.


Bone & Joint Research
Vol. 6, Issue 8 | Pages 522 - 529
1 Aug 2017
Ali AM Newman SDS Hooper PA Davies CM Cobb JP

Objectives

Unicompartmental knee arthroplasty (UKA) is a demanding procedure, with tibial component subsidence or pain from high tibial strain being potential causes of revision. The optimal position in terms of load transfer has not been documented for lateral UKA. Our aim was to determine the effect of tibial component position on proximal tibial strain.

Methods

A total of 16 composite tibias were implanted with an Oxford Domed Lateral Partial Knee implant using cutting guides to define tibial slope and resection depth. Four implant positions were assessed: standard (5° posterior slope); 10° posterior slope; 5° reverse tibial slope; and 4 mm increased tibial resection. Using an electrodynamic axial-torsional materials testing machine (Instron 5565), a compressive load of 1.5 kN was applied at 60 N/s on a meniscal bearing via a matching femoral component. Tibial strain beneath the implant was measured using a calibrated Digital Image Correlation system.


The Bone & Joint Journal
Vol. 98-B, Issue 10_Supple_B | Pages 16 - 21
1 Oct 2016
Jones GG Kotti M Wiik AV Collins R Brevadt MJ Strachan RK Cobb JP

Aims

To compare the gait of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) patients with healthy controls, using a machine-learning approach.

Patients and Methods

145 participants (121 healthy controls, 12 patients with cruciate-retaining TKA, and 12 with mobile-bearing medial UKA) were recruited. The TKA and UKA patients were a minimum of 12 months post-operative, and matched for pattern and severity of arthrosis, age, and body mass index.

Participants walked on an instrumented treadmill until their maximum walking speed was reached. Temporospatial gait parameters, and vertical ground reaction force data, were captured at each speed. Oxford knee scores (OKS) were also collected. An ensemble of trees algorithm was used to analyse the data: 27 gait variables were used to train classification trees for each speed, with a binary output prediction of whether these variables were derived from a UKA or TKA patient. Healthy control gait data was then tested by the decision trees at each speed and a final classification (UKA or TKA) reached for each subject in a majority voting manner over all gait cycles and speeds. Top walking speed was also recorded.


The Bone & Joint Journal
Vol. 97-B, Issue 4 | Pages 484 - 491
1 Apr 2015
van Arkel RJ Amis AA Cobb JP Jeffers JRT

In this in vitro study of the hip joint we examined which soft tissues act as primary and secondary passive rotational restraints when the hip joint is functionally loaded. A total of nine cadaveric left hips were mounted in a testing rig that allowed the application of forces, torques and rotations in all six degrees of freedom. The hip was rotated throughout a complete range of movement (ROM) and the contributions of the iliofemoral (medial and lateral arms), pubofemoral and ischiofemoral ligaments and the ligamentum teres to rotational restraint was determined by resecting a ligament and measuring the reduced torque required to achieve the same angular position as before resection. The contribution from the acetabular labrum was also measured. Each of the capsular ligaments acted as the primary hip rotation restraint somewhere within the complete ROM, and the ligamentum teres acted as a secondary restraint in high flexion, adduction and external rotation. The iliofemoral lateral arm and the ischiofemoral ligaments were primary restraints in two-thirds of the positions tested. Appreciation of the importance of these structures in preventing excessive hip rotation and subsequent impingement/instability may be relevant for surgeons undertaking both hip joint preserving surgery and hip arthroplasty.

Cite this article: Bone Joint J 2015; 97-B:484–91.


The Bone & Joint Journal
Vol. 95-B, Issue 10 | Pages 1326 - 1331
1 Oct 2013
Eilander W Harris SJ Henkus HE Cobb JP Hogervorst T

Orientation of the acetabular component influences wear, range of movement and the incidence of dislocation after total hip replacement (THR). During surgery, such orientation is often referenced to the anterior pelvic plane (APP), but APP inclination relative to the coronal plane (pelvic tilt) varies substantially between individuals. In contrast, the change in pelvic tilt from supine to standing (dPT) is small for nearly all individuals. Therefore, in THR performed with the patient supine and the patient’s coronal plane parallel to the operating table, we propose that freehand placement of the acetabular component placement is reliable and reflects standing (functional) cup position. We examined this hypothesis in 56 hips in 56 patients (19 men) with a mean age of 61 years (29 to 80) using three-dimensional CT pelvic reconstructions and standing lateral pelvic radiographs. We found a low variability of acetabular component placement, with 46 implants (82%) placed within a combined range of 30° to 50° inclination and 5° to 25° anteversion. Changing from the supine to the standing position (analysed in 47 patients) was associated with an anteversion change < 10° in 45 patients (96%). dPT was < 10° in 41 patients (87%). In conclusion, supine THR appears to provide reliable freehand acetabular component placement. In most patients a small reclination of the pelvis going from supine to standing causes a small increase in anteversion of the acetabular component.

Cite this article: Bone Joint J 2013;95-B:1326–31.


The Bone & Joint Journal
Vol. 95-B, Issue 6 | Pages 861 - 861
1 Jun 2013
Cobb JP

We welcome letters to the Editor concerning articles that have recently been published. Such letters will be subject to the usual stages of selection and editing; where appropriate the authors of the original article will be offered the opportunity to reply.


The Bone & Joint Journal
Vol. 95-B, Issue 3 | Pages 314 - 319
1 Mar 2013
Masjedi M Nightingale CL Azimi DY Cobb JP

We examined the relationship between the size of the femoral cam in femoroacetabular impingement (FAI) and acetabular pathomorphology to establish if pincer impingement exists in patients with a femoral cam.

CT scans of 37 symptomatic impinging hips with a femoral cam were analysed in a three-dimensional study and were compared with 34 normal hips. The inclination and version of the acetabulum as well as the acetabular rim angle and the bony acetabular coverage were calculated. These measurements were correlated with the size and shape of the femoral cams.

While the size of the femoral cam varied characteristically, the acetabular morphology of the two groups was similar in terms of version (normal mean 23° (sd 7°); cam mean 22° (sd 9°)), inclination (normal mean 57° (sd 5°); cam mean 56° (sd 5°)), acetabular coverage (normal mean 41% (sd 5%); cam mean 42% (sd 4%)) and the mean acetabular rim angle (normal mean 82° (sd 5°); cam mean 83° (sd 4°)).

We found no correlation between acetabular morphology and the severity of cam lesion and no evidence of either global or focal over-coverage to support the diagnosis of ‘mixed’ FAI. The femoral cam may provoke edge loading but removal of any acetabular bearing surface when treating cam FAI might induce accelerated wear.

Cite this article: Bone Joint J 2013;95-B:314–19.


Bone & Joint 360
Vol. 1, Issue 5 | Pages 34 - 35
1 Oct 2012
Cobb JP


Bone & Joint 360
Vol. 1, Issue 3 | Pages 2 - 4
1 Jun 2012
Cobb JP Andrews BL

In a global environment of rising costs and limited funds, robotic and computer-assisted orthopaedic technologies could provide the means to drive a necessary revolution in arthroplasty productivity. Robots have been used to operate on humans for 20 years, but the adoption of the technology has lagged behind that of the manufacturing industry. The use of robots in surgery should enable cost savings by reducing instrumentation and inventories, and improving accuracy. Despite these benefits, the orthopaedic community has been resistant to change. If the ergonomics and economics are right, robotic technology just might transform the provision of joint replacement.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 73 - 73
1 Mar 2012
Iranpour F Merican AM Hirschmann MT Cobb JP Amis AA
Full Access

Introduction

Differing descriptions of patellar motion relative to the femur have resulted from many in-vitro and in-vivo studies. The aim of this study was to examine the tracking behaviour of the patella. We hypothesized that patellar kinematics would correlate to the trochlear geometry.

Method

Seven normal fresh-frozen knees were CT scanned and their kinematics with quadriceps loading was measured by an optical tracker system and calculated in relation to the previously-established femoral axes. CT scans were used to reliably define frames of reference for the femur, tibia and the patella. A novel trochlear axis was defined, between the centres of best-fit medial and lateral trochlear articular surfaces spheres.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 75 - 75
1 Mar 2012
Iranpour F Salmasi YM Murphy M Hirschmann MT Amis A Cobb JP
Full Access

Introduction

Tibial patho-morphology has been described as a factor that predisposes to medial compartment osteoarthritis of the knee in 2D analysis. The aim of this study was to investigate whether the morphology of normal and pre-OA medial compartments are really different in 3 dimensions.

Method

A total of 20 normal (group A) and 20 pre-OA knees (group B) were included. Group A consisted of contra-lateral knees of young patients awaiting hip surgery and group B of asymptomatic contra-lateral knees of patients awaiting unicompartmental knee arthroplasty (UKA).

Using 3D reconstructions from CT scans, femurs were aligned to the transcondylar and anatomical axes. The medial femoral extension facet was modelled as a sphere. Its radius and the offsets between its centre and the medial flexion facet centre were measured. The tibias were aligned to a flat portion of the flexion facet (flexion facet plane. A model of analysis was developed by rotating several increments towards and away from the midline to obtain several sagittal section images. For each sagittal section the extension facet angle (EFA), its length, and the submeniscal plane angle and length were analysed.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 76 - 76
1 Mar 2012
Iranpour F Konala P Cobb JP Friederich N Hirschmann MT
Full Access

Introduction

SPECT/CT might be a promising diagnostic modality in patients with painful total knee arthroplasty. It was the purpose of our study to introduce a novel standardised SPECT/CT algorithm for assessing patients with painful primary total knee arthroplasty and to evaluate its clinical applicability and inter- and intra-observer variation and reliability.

Methods

A novel SPECT/CT localisation scheme, which consists of 9 tibial, 9 femoral and 4 patellar regions on standardised transverse, coronal, and sagittal slices was introduced. It was assessed in 18 consecutive patients with painful knees after total knee arthroplasty. The localisation and level of the tracer uptake on SPECT/CT were noted using a color coded 10 steps graded scale (0-100). The inter and intra-observer reliability were assessed. The femoral and tibial prosthetic component position was assessed in the CT images after 3D reconstruction and aligning them to standardised frames of reference. The average root mean square difference±standard deviations and ranges of these measured angles are presented along with the intraclass correlation coefficients for inter- and intraobserver reliability.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 74 - 74
1 Mar 2012
Iranpour F Sayani J Hirschmann MT Amis A Cobb JP
Full Access

Introduction

The trochlear groove plays a major role in the mechanics and patho-mechanics of the patellofemoral joint. Our primary goal was to compare normal, osteoarthritic and dysplastic PFJs in terms of angles and distances.

Method

Computed tomography scans of 40 normal knees (>55 years old), 9 knees with patellofemoral osteoarthritis (group A) and 12 knees with trochlear dysplasia (group B) were analysed using 3D software. The femurs were orientated using a robust frame of reference. A circle was fitted to the trochlear groove. The novel trochlear axis was defined as a line joining the centres of two spheres fitted to the trochlear surfaces, lateral and medial to the trochlear groove. The relationship between the femoral trochlea and the tibiofemoral joint was measured in term of angles and distances (offsets).T-test for paired samples was used (p<0.05).


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 7 | Pages 881 - 885
1 Jul 2011
Cobb JP Davda K Ahmad A Harris SJ Masjedi M Hart AJ

Large-head metal-on-metal total hip replacement has a failure rate of almost 8% at five years, three times the revision rate of conventional hip replacement. Unexplained pain remains a feature of this type of arthroplasty.

All designs of the femoral component of large-head metal-on-metal total hip replacements share a unique characteristic: a subtended angle of 120° defining the proportion of a sphere that the head represents. Using MRI, we measured the contact area of the iliopsoas tendon on the femoral head in sagittal reconstruction of 20 hips of patients with symptomatic femoroacetabular impingement. We also measured the articular extent of the femoral head on 40 normal hips and ten with cam-type deformities. Finally, we performed virtual hip resurfacing on normal and cam-type hips, avoiding overhang of the metal rim inferomedially.

The articular surface of the femoral head has a subtended angle of 120° anteriorly and posteriorly, but only 100° medially. Virtual surgery in a normally shaped femoral head showed a 20° skirt of metal protruding medially where iliopsoas articulates.

The excessive extent of the large-diameter femoral components may cause iliopsoas impingement independently of the acetabular component. This may be the cause of postoperative pain with these implants.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 5 | Pages 629 - 633
1 May 2011
Hirschmann MT Konala P Amsler F Iranpour F Friederich NF Cobb JP

We studied the intra- and interobserver reliability of measurements of the position of the components after total knee replacement (TKR) using a combination of radiographs and axial two-dimensional (2D) and three-dimensional (3D) reconstructed CT images to identify which method is best for this purpose.

A total of 30 knees after primary TKR were assessed by two independent observers (an orthopaedic surgeon and a radiologist) using radiographs and CT scans. Plain radiographs were highly reliable at measuring the tibial slope, but showed wide variability for all other measurements; 2D-CT also showed wide variability. 3D-CT was highly reliable, even when measuring rotation of the femoral components, and significantly better than 2D-CT. Interobserver variability in the measurements on radiographs were good (intraclass correlation coefficient (ICC) 0.65 to 0.82), but rotational measurements on 2D-CT were poor (ICC 0.29). On 3D-CT they were near perfect (ICC 0.89 to 0.99), and significantly more reliable than 2D-CT (p < 0.001).

3D-reconstructed images are sufficiently reliable to enable reporting of the position and orientation of the components. Rotational measurements in particular should be performed on 3D-reconstructed CT images. When faced with a poorly functioning TKR with concerns over component positioning, we recommend 3D-CT as the investigation of choice.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 547 - 547
1 Aug 2008
Kannan V Brust K Thevendran G Cobb JP
Full Access

Introduction: Complications following hip resurfacing (HR) occur primarily because of the surgeon’s inability to achieve optimal implant positioning, and the significant learning curve associated with this demanding procedure. Our study sought to look at the impact of navigation technologies on this learning curve.

Materials and Methods: Twenty medical students doing their BSc project took part in the study. Four types of synthetic femurs were used for the study viz., Normal anatomy (11students), Osteoarthritis (5), Coxa Vara and Coxa Valga(2). Each student was allowed to insert the guide wire according to their judgement in the femoral head using 3 systems:

Conventional instrumentation,

3D plan based on a CT scan of the particular bone, helped by a conventional jig

Navigation system.

This achieved angle was then compared with the angle originally planned for each bone in all three groups using digitizing arm.

Results: The range of error using the conventional method to insert a guide wire was 23deg (range −9 to 14, SD= 6.3), using the CT plan method, it was 22 deg (range −9 to 13, SD=6.6). Using the Navigation method it was 7 deg (range −5 to 2, SD=2.). Students who progressed from conventional through planning to navigation (group 1) were no more accurate than students who went straight to navigation without ever having used conventional instrumentation (group 3). Students produced similar accuracy even in their maiden attempt, on difficult anatomy when provided with navigation technology.

Discussion & Conclusion: This study has shown that motivated and enthusiastic students can achieve an expert level of accuracy very rapidly when provided with the appropriate level of technology. he development of surgeons who are able to deliver excellent outcomes depends more on technology than training.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 8 | Pages 1032 - 1038
1 Aug 2008
Cobb JP Dixon H Dandachli W Iranpour F

The rotational alignment of the tibia is an unresolved issue in knee replacement. A poor functional outcome may be due to malrotation of the tibial component. Our aim was to find a reliable method for positioning the tibial component in knee replacement.

CT scans of 19 knees were reconstructed in three dimensions and orientated vertically. An axial plane was identified 20 mm below the tibial spines. The centre of each tibial condyle was calculated from ten points taken round the condylar cortex. The tibial tubercle centre was also generated as the centre of the circle which best fitted eight points on the outside of the tubercle in an axial plane at the level of its most prominent point.

The derived points were identified by three observers with errors of 0.6 mm to 1 mm. The medial and lateral tibial centres were constant features (radius 24 mm (sd 3), and 22 mm (sd 3), respectively). An anatomical axis was created perpendicular to the line joining these two points. The tubercle centre was found to be 20 mm (sd 7) lateral to the centre of the medial tibial condyle. Compared with this axis, an axis perpendicular to the posterior condylar axis was internally rotated by 6° (sd 3). An axis based on the tibial tubercle and the tibial spines was also internally rotated by 5° (sd 10).

Alignment of the knee when based on this anatomical axis was more reliable than either the posterior surfaces or any axis involving the tubercle which was the least reliable landmark in the region.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 553 - 553
1 Aug 2008
Nakhla AI Lewis AD Cobb JP
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Introduction: The development of the ilioinguinal approach by the pioneering work of Letournel in 1965 has transformed the treatment of acetabular fractures. To date, this approach has been well established and few modifications have been described of the original approach. However, this approach is difficult, takes long time for exposure and closure of abdominal layers. The aim of this article is to report a modification of the approach which the authors have found particularly useful.

Material and Method: Cadaveric dissection showed that it was easier to detach the inguinal ligament from the anterior superior iliac spine and reflect the anterior abdominal wall as one layer, than by the classical approach through layers of the anterior abdominal wall. Closure was also simpler, in the cadaver, with the entire anterior abdominal wall reattaching satisfactorily by a single transosseous suture. The rest of the approach, including division of iliopectineal fascia and developing the three windows remains the same as in the original approach.

Results: To date, three acetabular fractures have been reduced and fixed using this modification. Besides substantially speeding up the exposure and closure, this approach allows superior distal visualization of the anterior column and wall, and the impression of rather less bleeding. No complications developed with the three cases treated through this modified approach, and specifically, there have been no hernias, nor has the lateral femoral cutaneous nerve of the thigh been damaged.

Discussion: This small study demonstrates a modification to a classic approach that seems to be both safe and fast We hope that further experience will also show reduction in problems associated with wound healing. Further work in progress may also show that femoral venous flow is less impeded by this approach as retraction is not against the unyielding inguinal ligament.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 566 - 566
1 Aug 2008
Nakhla AI Richards R Cobb JP
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Various frames of reference are routinely used for hip and knee arthroplasty. We hypothesised that the linea aspera is a constant anatomical feature which can be used as a frame of reference.

Twenty cadaveric femora were CT scanned with high resolution 1mm slices. Robin 3D software was used to manipulate the CT data. Three points were identified on the posterior aspect of the lesser trochanter, medial and lateral femoral condyles to position the femora in similar positions based on the posterior femoral plane (PFP). Centres of the femoral head and neck were derived by surface markers placed on the head and around the neck respectively. Joining the 2 centres gave head neck axis (HNA). The most prominent point on the linea aspera was identified at a level midway along the length of the femur. At that level the centre of the canal was derived by placing surface markers. Joining the most prominent point on the linea aspera to the centre of the canal identified our plane, linea aspera – centre plane (LCP). Angle measurements were made between PFP to HNA, PFP to LCP and LCP to HNA.

PFP to HNA is the traditional method for measuring anteversion angle which in our series had a mean of 13°, SD of 5 (range 5–24). PFP to LCP gave very similar results with mean 101°, SD 6 (range 92–112). However it was noted that there is weak correlation between PFP to HNA angle and PFP to LCP angle for each femur. LCP to HNA measurements were more variable with mean 89°, SD 8 (range 76–108).

From these data we conclude that the proximal half of the femur has more variable torsion compared to the distal half. This study shows that the linea aspera should not be used as a frame of reference for hip nor knee arthroplasties. However, further studies are needed to evaluate the linea aspera in-vivo where it is expected to be more prominent and easier to identify.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 564 - 564
1 Aug 2008
Nakhla AI Richards R Turner A Rodriguez F Barrett A Lewis AD Hart A Cobb JP
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The use of intramedullary column screws in the treatment of acetabular fractures is becoming more widely utilized. The development of percutaneous methods to insert these screws under image intensifier guidance is one of the main reasons for their increased use. Few groups are navigating insertion of these screws. The available screws are cannulated 6.5–8 mm screws. Most surgeons prefer using 3.2 mm guide wires to reduce deflection. With a shank diameter of 4.5 mm, 3.2 mm cannulation significantly weakens the screws. We postulated that both columns, specially the posterior column can accommodate larger screw diameters which will increase the stability of fixation allowing earlier full weight bearing. The currently used screws were designed for fixation of femoral neck fractures. As percutaneous fixation of acetabular fractures is a growing area of interest, this warrants designing suitable screws with larger diameters.

Eight CT scans of the adult pelvis –performed for non fracture related indications-, were studied (7 females, 1 male). We found that the anatomical cross-section of the columns is irregular but approximately triangular. The method we used to determine the largest diameter of a screw to fit each column was fitting cylinders in the columns. Robin’s 3D software was used to segment acetabula and convert the CT data into polygon mesh (stereolithography STL format) bone surfaces at an appropriate Hounsfield value. The resulting STL files were imported in Robin’s Cloud software, where polygon mesh cylinders of 10 mm diameter were fitted in each column. These cylinders were then manipulated to achieve best fit and their diameters were gradually increased to the biggest diameter which still fitted in the column.

The mean diameters of the fitted cylinders were 10.8 mm (range: 10–13mm) and 15.2 mm (range 14–16.5mm) for the anterior and posterior columns respectively.

To our knowledge, this is the first investigation to study the cross sectional dimensions of the anterior and posterior columns of the acetabulum. Our small sample shows that both columns can safely accommodate larger screws than those currently used. We plan to investigate this further using cadavers.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 564 - 565
1 Aug 2008
Nakhla AI Richards R Cobb JP
Full Access

Various frames of reference are routinely used for hip and knee arthroplasty. We hypothesised that the linea aspera is a constant anatomical feature which can be used as a frame of reference.

Twenty cadaveric femora were CT scanned with high resolution 1mm slices. Robin 3D software was used to manipulate the CT data. Three points were identified on the posterior aspect of the lesser trochanter, medial and lateral femoral condyles to position the femora in similar positions based on the posterior femoral plane (PFP). Centres of the femoral head and neck were derived by surface markers placed on the head and around the neck respectively. Joining the 2 centres gave head neck axis (HNA). The most prominent point on the linea aspera was identified at a level midway along the length of the femur. At that level the centre of the canal was derived by placing surface markers. Joining the most prominent point on the linea aspera to the centre of the canal identified our plane, linea aspera – centre plane (LCP). Angle measurements were made between PFP to HNA, PFP to LCP and LCP to HNA.

PFP to HNA is the traditional method for measuring anteversion angle which in our series had a mean of 13°, SD of 5 (range 5–24). PFP to LCP gave very similar results with mean 101°, SD 6 (range 92–112). However it was noted that there is weak correlation between PFP to HNA angle and PFP to LCP angle for each femur. LCP to HNA measurements were more variable with mean 89°, SD 8 (range 76–108).

From these data we conclude that the proximal half of the femur has more variable torsion compared to the distal half. This study shows that the linea aspera should not be used as a frame of reference for hip nor knee arthroplasties. However, further studies are needed to evaluate the linea aspera in-vivo where it is expected to be more prominent and easier to identify.


The Journal of Bone & Joint Surgery British Volume
Vol. 89-B, Issue 8 | Pages 1130 - 1130
1 Aug 2007
COBB JP


The Journal of Bone & Joint Surgery British Volume
Vol. 88-B, Issue 11 | Pages 1513 - 1518
1 Nov 2006
Henckel J Richards R Lozhkin K Harris S Baena FMRY Barrett ARW Cobb JP

Surgeons need to be able to measure angles and distances in three dimensions in the planning and assessment of knee replacement. Computed tomography (CT) offers the accuracy needed but involves greater radiation exposure to patients than traditional long-leg standing radiographs, which give very little information outside the plane of the image.

There is considerable variation in CT radiation doses between research centres, scanning protocols and individual scanners, and ethics committees are rightly demanding more consistency in this area.

By refining the CT scanning protocol we have reduced the effective radiation dose received by the patient down to the equivalent of one long-leg standing radiograph. Because of this, it will be more acceptable to obtain the three-dimensional data set produced by CT scanning. Surgeons will be able to document the impact of implant position on outcome with greater precision.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 4 | Pages 534 - 539
1 Apr 2005
Cobb JP Ashwood N Robbins G Witt JD Unwin PS Blunn G

Massive endoprostheses using a cemented intramedullary stem are widely used to allow early resumption of activity after surgery for tumours. The survival of the prosthesis varies with the anatomical site, the type of prosthesis and the mode of fixation. Revision surgery is required in many cases because of aseptic loosening. Insertion of a second cemented endoprosthesis may be difficult because of the poor quality of the remaining bone, and loosening recurs quickly.

We describe a series of 14 patients with triplate fixation in difficult revision or joint-sparing tumour surgery with a minimum follow-up of four years. The triplate design incorporated well within a remodelled cortex to achieve osseomechanical integration with all patients regaining their original level of function within five months.

Our preliminary results suggest that this technique may provide an easy, biomechanically friendly alternative to insertion of a further device with an intramedullary stem, which has a shorter lifespan in revision or joint-sparing tumour surgery. A short segment of bone remaining after resection of a tumour will not accept an intramedullary stem, but may be soundly fixed using this method.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 110 - 111
1 Feb 2003
Davidson AW Witt J Cobb JP
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To assess the performance and success of joint sparing limb salvage surgery in high grade malignancy, in terms of function, complications, recurrence and survival, as compared to joint resection.

We report a ten-year experience of twenty patients with high grade malignancies of bone which did not cross the epiphyseal plate. They underwent not only limb salvage surgery but also joint preservation. The aim of this is to preserve function in the joint and to prevent the inevitable wear of prosthetic joints requiring revision surgery. The age range was 4 - 25 years (mean 13. 5). The Diagnoses were 14 Osteosarcomas and 6 Ewings sarcomas. Mean follow up was 49 months. There were 13 femoral & 7 tibial malignancies. 12 underwent complex biological fixation with a combination of reimplanted autoclaved or irradiated bone; vascularised fibular graft; femoral or humeral allograft. In 8 cases custom made hydroxyapatite coated prostheses were used to replace the resected bone. This surgery must clearly be evaluated in the context of recurrence, particularly as this is associated with an increased risk of metastases and death. Analysis of our results to date has not shown a greater rate of complications. We experienced one recurrence, and one death. The custom prostheses group had fewer complications and operations. Functionally these patients report near normal limbs and joints and do not report any limitation of activities.

Joint sparing limb salvage surgery is extremely worthwhile as it produces a significantly better functioning limb and lower morbidity, with less likelihood of revision surgery. We have not found a higher risk of post-operative complications, recurrence or death. Furthermore massive prosthetic replacement is quicker, osseointegrates reliably and is associated with a lower complication and further operation rate.


The Journal of Bone & Joint Surgery British Volume
Vol. 82-B, Issue 8 | Pages 1125 - 1128
1 Nov 2000
Witt JD Hall-Craggs MA Ripley P Cobb JP Bown SG

We report the results of a prospective study of 23 patients in which interstitial laser photocoagulation (ILP) was used to treat an osteoid osteoma. ILP is a technique in which tumour tissue is destroyed by direct heating using low-power laser light energy delivered by thin (400 μm) optical fibres which are introduced percutaneously into the tumour under image guidance.

Pain was evaluated before operation and at the latest follow-up using a visual analogue scale with 0 denoting no pain and 10 the worst pain imaginable. The mean follow-up was for 15 months.

The results showed that the mean pain score decreased from 7.5 before operation to 0.95 at the latest follow-up. Fourteen patients had no pain and eight had minor discomfort, not requiring analgesia. One patient required a second procedure because placement of the fibre had not been accurate enough and one developed recurrent symptoms eight months after treatment. All patients were satisfied with the operation because of the rapid resolution of pain, the minimally invasive nature of the procedure, and the fact that there was no postoperative restriction of activity.