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Orthopaedic Proceedings
Vol. 106-B, Issue SUPP_6 | Pages 19 - 19
2 May 2024
Shaarani S Moriarty P Vles G Haddad F Konan S
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We had previously reported on early outcomes on a new fluted, titanium, monobloc stem with a three degree taper that has been designed for challenging femoral reconstruction in the setting of extensive bone loss. The aim of this study was to report its mid-term clinical and radiographic outcomes.

This is a retrospective review of prospectively collected data carried out at a single institution between Jan 2017 and Dec 2019. 85 femoral revisions were performed using a new tapered, fluted, titanium, monobloc (TFTM) revision stem. Complications, clinical and radiographic data were obtained from medical records and a locally maintained database. Clinical outcomes were assessed using the Oxford Hip Score (OHS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). All post-operative radiographs were analysed for subsidence, osteolysis and femoral cortical bone remodelling.

Mean follow-up was 60 months (range 28–84 months). Subsidence of 1.2 mm was noted in one patient. No cases of clinically significant subsidence (10 mm) were observed. At final follow-up, a statistically significant improvement was noted in functional outcome scores. The mean OHS preoperatively and at final follow-up were 24 (SD 13) and 42 (SD15). p = 0.04 mean difference 18 (95% CI 15–22). The mean WOMAC scores preoperatively and at final follow-up were 62 (SD23) and 88 (SD7) respectively (p < 0.001, mean difference 26; 95% CI 21–34). No stem fractures were noted within the follow-up period. Two patients had revision of the stem's one for infection and another for persistent pain.

Positive mid-term clinical and radiological outcomes have been observed with this tapered, fluted, titanium, monobloc stem. Based on these results, this implant may be considered as a viable option in the majority of uncemented femoral revisions.


The Bone & Joint Journal
Vol. 106-B, Issue 5 | Pages 515 - 515
1 May 2024
Kayani B D. Luo T S. Haddad F


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_7 | Pages 87 - 87
1 Jul 2022
Rajput V Fontalis A Plastow R Kayani B Giebaly D Hansejee S Magan A Haddad F
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Abstract

Introduction

Coronal plane alignment of the knee (CPAK) classification utilises the native arithmetic hip-knee alignment to calculate the constitutional limb alignment and joint line obliquity which is important in pre-operative planning. The objective of this study was to compare the accuracy and reproducibility of measuring the lower limb constitutional alignment with the traditional long leg radiographs versus computed tomography (CT) used for pre-operative planning in robotic-arm assisted TKA.

Methods

Digital long leg radiographs and pre-operative CT scan plans of 42 patients (46 knees) with osteoarthritis undergoing robotic-arm assisted total knee replacement were analysed. The constitutional alignment was established by measuring the medial proximal tibial angle (mPTA), lateral distal femoral angle (LDFA), weight bearing hip knee alignment (WBHKA), arithmetic hip knee alignment (aHKA) and joint line obliquity (JLO). Furthermore, the Coronal Plane Alignment of the Knee (CPAK) classification was utilised to classify the patients based on their coronal knee alignment phenotype.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 15 - 15
1 Nov 2021
Kayani B Bawwa J Tahmassebi J Fontalis A Wardle N Middleton R Shardlow D Hutchinson J Haddad F
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This study reports the ten-year outcomes of a three-arm, multicentre randomised controlled trial comparing Cobalt-Chrome (CoCr) and Oxidised Zirconium (OxZr) femoral heads with ultra-high molecular weight polyethylene (UHMWPE) versus highly cross-linked polyethylene (XLPE) liners in total hip arthroplasty (THA).

Patients undergoing THA from four institutions were prospectively randomised into three groups. Group A received a CoCr femoral head and XLPE liner; Group B received an OxZr femoral head and XLPE liner; and Group C received an OxZr femoral head and UHMWPE liner. The outcomes of 262 study patients were analysed at ten years follow-up.

At ten years, increased linear wear rates were recorded in group C compared to group A (0.133 ± 0.21 mm/yr vs 0.031 ± 0.07 mm/yr respectively, p<0.001) and group B (0.133 ± 0.21 mm/yr vs 0.022 ± 0.05 mm/yr respectively, p<0.001). Patients in group C had increased risk of osteolysis and aseptic loosening requiring revision surgery compared with group A (7/133 vs 0/133 respectively, p=0.007) and group B (7/133 vs 0/135 respectively, p=0.007). There was a non- significant trend towards increased liner wear rates in group A compared to group B (0.031 ± 0.07 mm/yr vs 0.022 ± 0.05 mm/yr respectively, p=0.128). All three groups were statistically comparable preoperatively and at ten years follow-up from a clinical score perspective.

The use of UHMWPE was associated with progressively increased annual liner wear rates. At ten years follow-up, this translated to an increased incidence of osteolysis and aseptic loosening requiring revision, compared with XLPE. Femoral heads composed of OxZr were associated with a non-significant trend towards reduced wear rates compared to CoCr, but this did not translate to any differences in osteolysis, functional outcomes, or revision surgery between the two treatments groups.


Bone & Joint Open
Vol. 1, Issue 6 | Pages 267 - 271
12 Jun 2020
Chang J Wignadasan W Kontoghiorghe C Kayani B Singh S Plastow R Magan A Haddad F

Aims

As the peak of the COVID-19 pandemic passes, the challenge shifts to safe resumption of routine medical services, including elective orthopaedic surgery. Protocols including pre-operative self-isolation, COVID-19 testing, and surgery at a non-COVID-19 site have been developed to minimize risk of transmission. Despite this, it is likely that many patients will want to delay surgery for fear of contracting COVID-19. The aim of this study is to identify the number of patients who still want to proceed with planned elective orthopaedic surgery in this current environment.

Methods

This is a prospective, single surgeon study of 102 patients who were on the waiting list for an elective hip or knee procedure during the COVID-19 pandemic. Baseline characteristics including age, ASA grade, COVID-19 risk, procedure type, surgical priority, and admission type were recorded. The primary outcome was patient consent to continue with planned surgical care after resumption of elective orthopaedic services. Subgroup analysis was also performed to determine if any specific patient factors influenced the decision to proceed with surgery.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 60 - 60
1 May 2019
Haddad F
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Periprosthetic joint infection (PJI) is a major complication affecting >1% of all total knee arthroplasties, with compromise in patient function and high rates of morbidity and mortality. There are also major socioeconomic implications. Diagnosis is based on a combination of clinical features, laboratory tests (including serum and articular samples) and diagnostic imaging. Once confirmed, prompt management is required to prevent propagation of the infection and further local damage. Non-operative measures include patient resuscitation, systemic antibiotics, and wound management, but operative intervention is usually required. Definitive surgical management requires open irrigation and debridement of the operative site, with or without exchange arthroplasty in either a single or two-stage approach. In all options, the patient's fitness, comorbidities and willingness for further surgery should be considered, and full intended benefits and complications openly discussed. Late infection almost invariably leads to implant removal but early infections and acute haematogenous infections can be managed with implant retention – the challenge is to retain the original implant, having eradicated infection and restored full function.

Debridement with component retention: Open debridement is indicated for acute postoperative infections or acute haematogenous infections with previously well-functioning joints. To proceed with this management option the following criteria must be met: short duration of symptoms - ideally less than 2–3 weeks but up to 6; well-fixed and well-positioned prostheses; healthy surrounding soft tissues. Open debridement is therefore not an appropriate course of management if symptoms have been prolonged – greater than 6 weeks, if there is a poor soft tissue envelope and scarring, or if a revision arthroplasty would be more appropriate due to loosening or malposition of the implant. It is well documented in the literature that there is an inverse relationship between the duration of symptoms and the success of a debridement. It is thought that as the duration of symptoms increases, other factors such as patient comorbidities, soft tissue status and organism virulence play an increasingly important role in determining the outcome.

There is a caveat. Based on our learning in the hip, when we see an acute infection where periprosthetic implants are used, it is much easier to use this time-limited opportunity to remove the implants and the associated biofilm and do a single-stage revision instead of just doing a debridement and a change of insert. This will clearly be experience and prosthesis-dependent but if the cementless implant is easy to remove, then it should be explanted. One critical aspect of this procedure is to use one set of instruments and drapes for the debridement and to then implant the new mobile parts and close using fresh drapes and clean instruments. Units that have gained expertise in single-stage revision will find this easier to do. After a debridement, irrigation, and change of insert, patients continue on intravenous antibiotics until appropriate cultures are available. Our multidisciplinary team and infectious disease experts then take over and will dictate antibiotic therapy thereafter. This is typically continued for a minimum of three months. Patients are monitored clinically, serologically, and particularly in relation to nutritional markers and general wellbeing. Antibiotics are stopped when the patients reach a stable level and are well in themselves. All patients are advised to re-present if they have an increase in pain or they feel unwell.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_8 | Pages 104 - 104
1 May 2019
Haddad F
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There has been an evolution in revision hip arthroplasty towards cementless reconstruction. Whilst cemented arthroplasty works well in the primary setting, the difficulty with achieving cement fixation in femoral revisions has led to a move towards removal of cement, where it was present, and the use of ingrowth components. These have included proximally loading or, more commonly, distally fixed stems. We have been through various iterations of these, notably with extensively porous coated cobalt chrome stems and recently with taper-fluted titanium stems. As a result of this, cemented stems have become much less popular in the revision setting.

Allied to concerns about fixation and longevity of cemented fixation revision, there were also worries in relation to bone cement implantation syndrome when large cement loads were pressurised into the femoral canal at the time of stem cementation. This was particularly the case with longer stems. Technical measures are available to reduce that risk but the fear is nevertheless there.

In spite of this direction of travel and these concerns, there is, however, still a role for cemented stems in revision hip arthroplasty. This role is indeed expanding.

First and foremost, the use of cement allows for local antibiotic delivery using a variety of drugs both instilled in the cement at the time of manufacture or added by the surgeon when the cement is mixed. This has advantages when dealing with periprosthetic infection. Thus, cement can be used both as interval spacers but also for definitive fixation when dealing with periprosthetic hip infection. The reconstitution of bone stock is always attractive, particularly in younger patients or those with stove pipe canals. This is achieved well using impaction grafting with cement and is another extremely good use of cement.

In the very elderly or those in whom proximal femoral resection is needed at the time of revision surgery, distal fixation with cement provides a good solution for immediate weight bearing and does not have the high a risk of fracture seen with large cementless stems.

Cement is also useful in cases of proximal femoral deformity or where cement has been used in a primary arthroplasty previously. We have learnt that if the cement is well-fixed then the bond of cement-to-cement is excellent and therefore retention of the cement mantle and recementation into that previous mantle is a great advantage. This avoids the risks of cement removal and allows for much easier fixation. Stems have been designed specifically to allow this cement-in-cement technique. It can be used most readily with polished tapered stems - tap out a stem, gain access at the time of revision surgery and reinsert it. It is, however, now increasingly used when any cemented stems are removed provided that the cement mantle is well fixed. The existing mantle is either wide enough to accommodate the cement-in-cement revision or can be expanded using manual instruments or ultrasonic tools. The cement interface is then dried and a new stem cemented in place.

Whilst the direction of travel in revision hip arthroplasty has been towards cementless fixation, particularly with tapered distally fixed designs, the reality is that there is still a role for cement for its properties of immediate fixation, reduced fracture risk, local antibiotic delivery, impaction grafting and cement-in-cement revision.


Robotic assisted surgery aims to reduce surgical errors in implant positioning and better restore native hip biomechanics compared to conventional techniques for total hip arthroplasty (THA). The primary objective of this study was to compare accuracy in restoring the native centre of hip rotation in patients undergoing conventional manual THA versus robotic-arm assisted THA. Secondary objectives were to determine differences between these treatment techniques for THA in achieving the planned combined offset, cup inclination, cup version, and leg-length correction.

This prospective cohort study included 50 patients undergoing conventional manual THA and 25 patients receiving robotic-arm assisted THA. All operative procedures were undertaken by a single surgeon using the minimally-invasive posterior approach. Two independent blinded observers recoded all radiological outcomes of interest using plain radiographs. Patients in both treatment groups were well-matched for age, gender, body mass index, laterality of surgery, and ASA scores.

Interclass correlation coefficient was 0.92 (95% CI: 0.84 – 0.95) for intra-observer agreement and 0.88 (95% CI: 0.82–0.94) for inter-observer agreement in all study outcomes. Robotic THA was associated with improved accuracy in restoring the native horizontal (p<0.001) and vertical (p<0.001) centres of rotation, and improved preservation of the patient's native combined offset (P<0.001) compared to conventional THA. Robotic THA improved accuracy in positioning of the acetabular cup within the combined safe zones of inclination and anteversion described by Lewinnek et al (p=0.02) and Callanan et al (p=0.01) compared to conventional THA (figures 1–2). There was no difference between the two treatment groups in achieving the planned leg-length correction (p=0.10).

Robotic-arm assisted THA was associated with improved accuracy in restoring the native centre of rotation, better preservation of the combined offset, and more precise acetabular cup positioning within the safe zones of inclination and anteversion compared to conventional manual THA.

Robotic-arm assisted THA enables improved preservation of native hip biomechanics compared to conventional manual THA.

For any figures or tables, please contact authors directly: fsh@fareshaddad.net


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 57 - 57
1 Jun 2018
Haddad F
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Restoring native hip biomechanics is crucial to the success of THA. This is reflected both in terms of complications after surgery such as instability, leg length inequality, pain and limp; and in terms of patient satisfaction. The challenge that remains is that of achieving optimal implant sizing and positioning so as to restore, as closely as possible, the native hip biomechanics specific to the hip joint being replaced. This would optimise function and reduce complications, particularly, instability. (Mirza et al., 2010). Ideally, this skill should also be reproducible irrespective of the surgeon's experience, volume of surgery and learning curve.

The general consensus is that the most substantial limiting factor in a THA is the surgeon's performance and as a result, human errors and unintended complications are not completely avoidable (Tarwala and Dorr, 2011). The more challenging aspects include acetabular component version, sizing and femoral component sizing, offset and position in the femoral canal. This variability has led to interest in technologies for planning THA, and technologies that help in the execution of the procedure. Advances in surgical technology have led to the development of computer navigation and robotic systems, which assist in pre-operative planning and optimise intra-operative implant positioning.

The evolution of surgical technology in lower limb arthroplasty has led to the development of computer navigation and robotics, which are designed to minimise human error and improve implant positioning compared to pre-operative templating using plain radiographs. It is now possible to use pre-operative computerised tomography (image-based navigation) and/or anatomical landmarks (non-imaged-based navigation) to create three-dimensional images of each patient's unique anatomy. These reconstructions are then used to guide bone resection, implant positioning and lower limb alignment.

The second-generation RIO Robotic Arm Interactive Orthopaedic system (MAKO Surgical) uses pre-operative computerised tomography to build a computer-aided design (CAD) model of the patient's hip. The surgeon can then plan and execute optimal sizing and positioning of the prostheses to achieve the required bone coverage, minimise bone resection, restore joint anatomy and restore lower limb biomechanics. The MAKO robotic software processes this information to calculate the volume of bone requiring resection and creates a three-dimensional haptic window for the RIO-robotic arm to resect. The RIO-robotic arm has tactile and audio feedback to resect bone to a high degree of accuracy and preserve as much bone stock as possible.

We have used this technology in the hip to accurately reproduce the anteversion, closure and center of rotation that was planned for each hip. Whilst the precise safe target varies from patient to patient, the ability to reproduce native biomechanics, to gain fixation as planned and to get almost perfect length and offset are a great advantage. Complications such as instability and leg length inequality are thus dramatically reduced.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 1 - 1
1 Jun 2018
Haddad F
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We live in an era where younger, fitter, more active patients are presenting with the symptoms and signs of degenerative joint disease and require total knee and total hip arthroplasty at a young age. At the same time, this population of patients is living longer and longer and is likely to create new and more complex failure modes for their implants. The ideal solution is a biological one, whereby we can either prevent joint degradation or catch it in its early stages and avoid further deterioration. There may also be advances along the way in terms of partial arthroplasty and focal resurfacing that will help us prevent the need for total joint arthroplasty.

There are several tensions that need to be considered. Should we resurface / replace early, particularly now that we have access to navigation and robotics and can effectively customise the implants to the patient's anatomy and their gait pattern? This would allow good function at a young age. Or should we wait as long as possible and risk losing some function for the sake of preserving the first arthroplasty for the lifetime of the patient?

There are some key issues that we still do not fully understand. The lack of true follow-up data beyond 20 or 30 years is worrying. The data available tends to be from expert centers, and always has a dramatic loss to follow-up rate. We worry about bearing surfaces and how those materials will behave over time but we really do not know the effect of chronic metal exposure over several decades, nor do we really understand what happens to bone as it becomes more and more osteopenic and fragile around implants. We have largely recorded but ignored stress shielding, whereas this may become a very significant issue as our patients get older, more fragile, more sarcopaenic and more neurologically challenged. All the fixation debates that we have grappled with, may yet come back to the fore. Can ingrowth lead to failure problems later on? Will more flexible surfaces and materials be required to fit in with the elasticity of bone?

We have failed dramatically at translating the in vitro to the in vivo model. It seems that the in vitro model tells us when failure is going to occur but success in vitro does not predict success in vivo. We, therefore, cannot assume that long-term wear data from simulators will necessarily translate to the extreme situations in vivo where the loading is not always idealised, and can create adverse conditions.

We must, therefore, consider further how to improve and enhance our interventions. There is no doubt that the avoidance of arthroplasty needs to be at the heart of our thinking but, ultimately, if arthroplasty is to be performed, it needs to be performed expertly and in such a way as to minimise later failure. It also, clearly, needs to be cost-effective. The next stage will no doubt involve close cooperation between surgeons, engineers and industry partners to identify individualised surgical targets, select an appropriate prosthesis to minimise soft-tissue strain and develop a reproducible method of achieving accurate implantation. An ideal outcome can only be achieved by an appropriately trained surgeon selecting the optimal prosthesis to implant in the correct position in the well-selected patient.

In the longer term, our choice of implants and the way that they are inserted and fixed must take into account the evolving physiology of our patients, the nature of our devices and how to limit harm from them, and the long-term impact of the materials used which we sometimes still do not understand.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 91 - 91
1 Jun 2018
Haddad F
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The infected joint arthroplasty continues to be a very challenging problem. Its management remains expensive, and places an increasing burden on health care systems. It also leads to a long and difficult course for the patient, and frequently a suboptimal functional outcome. The choice of a particular treatment program will be influenced by a number of factors. These include the acuteness or chronicity of the infection; the infecting organism(s), its antibiotic sensitivity profile and its ability to manufacture glycocalyx; the health of the patient; the fixation of the prosthesis; the available bone stock; and the particular philosophy and training of the surgeon.

For most patients, antibiotics alone are not an acceptable method of treatment, and surgery is necessary. The standard of care for established infection is two stage revision with antibiotic loaded cement during the interval period and parental antibiotic therapy for six weeks. Single stage revision may have economic and functional advantages, however. We have devised a protocol that dictates the type of revision to be undertaken based on host, organism and local factors.

Our protocol has included single stage revision using antibiotic loaded cement in both THA and TKA. This was only undertaken when sensitive organisms were identified pre-operatively by aspiration and appropriate antibiotics were available to use in cement. Patients with immunocompromise, multiple infecting organisms or recurrent infection were excluded. Patients with extensive bone loss that required allograft reconstruction or where a cementless femoral component was necessary were also excluded.

Our algorithm was validated first in the hip and extended to infected TKA in 2004. This protocol has now been applied in over 100 TKA revisions for infection between 2004 and 2009. Our single stage revision rate is now over 25%. We continue to see a lower reinfection rate in these carefully selected patients, with high rates of infection control and satisfaction and better functional and quality of life scores than our two stage revision cases.

Whilst our indications are arbitrary and not based on specific biomarkers, we present excellent results for selective single stage exchange. A minimum three year follow-up suggests that these patients have shorter hospital stays, higher satisfaction rates and better knee scores. An ongoing evaluation is in place. One stage revision arthroplasty for infection offers potential clinical and economic advantages in selected patients.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_10 | Pages 111 - 111
1 Jun 2018
Haddad F
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The infected joint arthroplasty continues to be a very challenging problem. Its management remains expensive, and places an increasing burden on health care systems. It also leads to a long and difficult course for the patient, and frequently a suboptimal functional outcome. The choice of a particular treatment program will be influenced by a number of factors. These include the acuteness or chronicity of the infection; the infecting organism(s), its antibiotic sensitivity profile and its ability to manufacture glycocalyx; the health of the patient; the fixation of the prosthesis; the available bone stock; and the particular philosophy and training of the surgeon. Although there have been multiple developments to enhance our ability to effect two-stage techniques whilst limiting inpatient stay, cost and patient morbidity - these include functional spacers, the use of local as well as systemic antibiotics, and home intravenous therapy programmes – there is nevertheless still a considerable morbidity and mortality to the two-stage process, and a massive cost to the patient who has to have two operations with an unpredictable interval period in between and to the local tissues which have already been damaged and are violated on two occasions. The push for one-stage surgery has generally been from centers who are passionate about that technique and has involved a combination of knowing the organism in question prior to surgery, a very radical debridement, the use of hinge / tumor-type implants and prolonged antibiotic therapy post-surgery. The last decade has seen an evolution whereby we have recognised that treatment may be tailored to the patient. There is a big difference between a relatively healthy host and someone with multiple comorbidities, and a big difference between infection with a relatively benign organism and polymicrobial infection with multi-resistant bacteria or fungi. There has, therefore, been increased interest in the use of single-stage revision in order to decrease morbidity, potentially decrease mortality and to decrease cost to the health care system. Single stage revision may have economic and functional advantages, however. We have devised a protocol that dictates the type of revision to be undertaken based on host, organism and local factors.

Whilst we believe that there is a role for both single- and two-stage techniques in our armamentarium, we have gradually evolved to increasing use of single-stage surgery. We use antibiotic-loaded cement whenever possible but can reconstruct most cases using semiconstrained implants without resorting to a hinge.

We continue to see a lower reinfection rate in these carefully selected patients, with high rates of infection control and satisfaction and better functional and quality of life scores than our two-stage revision cases. We use hinge reconstruction in less than 20% of cases.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 21 - 21
1 Jan 2018
Haddad F Ibrahim M Twaij H
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Periprosthetic joint infection (PJI) remains a challenging complication following Total Hip Arthroplasty (THA). It is associated with high levels of morbidity, mortality and is time consuming and expensive to treat. Our management generally relies on identification of the infecting organism(s) in order to define the appropriate treatment strategy. Patients with culture-negative PJI poses a greater challenge to surgeons and to the wider multidisciplinary team.

This study compares the outcomes of 50 consecutive complex culture-positive (deemed unsuitable for single stage exchange) and 50 culture-negative THAs managed with two-stage revision arthroplasty with a minimum of five years follow-up.

Culture-negative PJIs were associated with older age, smoking, external referral source and greater use of preoperative antibiotics. There was however no significant difference in outcome between these groups of patients with a similar complication rates and reinfection rates of 6% at 5 years.

Culture negative periprosthetic sepsis generates concern, and is often considered a poor prognostic indicator. This study suggests that a strict 2 stage protocol is associated with satisfactory outcomes in such cases.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_15 | Pages 24 - 24
1 Aug 2017
Haddad F
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Since its inception, knee arthroplasty has struggled to balance the requirements of relieving pain and restoring function in a durable way. Although highly successful in improving symptoms as measured by traditional outcome measures and achieving longevity, numerous studies have shown the problems that exist, even with well-implanted components of modern design. Some patients complain of ongoing functional limitation, discomfort, and pain. There are still many challenges in knee arthroplasty. We have a young population that is increasingly active that requires these procedures and yet they are living to a ripe old age and remaining ambulant into their 80s and 90s. We have focussed for the last decade on improving function and satisfaction in knee arthroplasty but we should not forget the fact that the highest failure rate is seen in our young patients and that we really do need a durable solution that will last several decades. There are several tensions that need to be considered. Should we resurface the knee early, particularly now that we have access to navigation and robotics and can effectively customise the implants to the patient's anatomy and their gait pattern? This would allow good function at a young age. Or should we wait as long as possible and risk losing some function for the sake of preserving the first arthroplasty for the lifetime of the patient?

Should we for example accept alignment paradigms that we know give us longevity or should we go with alternative kinematic or anatomical alignment techniques that may well give us better function but could compromise long-term fixation? Both registries and the long-term studies available suggest that we can expect good survivorship into the second decade for older patients and for some into the third decade, but data beyond that is sparse and is not available with contemporaneous implants. Changing the polyethylene in the knee may prove to be successful but may yet be nowhere near as beneficial as it has been in the hip. There has also been all too little work to consider the changing physiology of the bone. Will the increasing trend for cementless implants lead to longer lasting osseointegration or will it lead to periprosthetic fractures through areas of stress shielding? We have been spared somewhat thus far in the knee the issue of local metal ion effects and systemic issues that we have seen in the hip. If our implants last longer and are treated more brutally by an active patient population, we may yet see more problems. At the same time, we have to continue evolving our technologies and yet be cost effective and affordable. Our focus on operative efficiency, early discharge, rapid recovery and a return to full function must not compromise our goals and plans for implant longevity. The next stage will no doubt involve close co-operation between surgeons, engineers and industry partners to identify individual surgical targets, select an appropriate prosthesis to minimise soft-tissue strain and develop a reproducible method of achieving accurate implantation. However, in seeking to solve the problems seen in a proportion of arthroplasty patients, the achievements of ‘traditional’ total knee arthroplasty should not be overlooked. The results achieved by such methods in all three domains: pain relief, functional restoration and longevity, should act as baseline measures for newer techniques and designs. Improvements in any one domain should not be at the expense of another. An ideal outcome can only be achieved by an appropriately trained surgeon selecting the optimal prosthesis to implant in the correct position in the well-selected patient.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_15 | Pages 58 - 58
1 Aug 2017
Haddad F
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The infected joint arthroplasty continues to be a very challenging problem. No test has 100% diagnostic accuracy for PPI and the treating surgeon must correlate the clinical and radiographic presentation with a combination of blood tests, synovial fluid analysis, microbiological and histopathological evaluation of periprosthetic tissue and intra-operative inspection to reach a definitive diagnosis. Diagnosis should begin with a high index of suspicion for new onset of pain or symptoms in well-functioning joints. Plain radiographs may identify osteolysis or early signs of implant failure and should be promptly investigated further for PPI.

Peripheral blood ESR and CRP remain the most widely used next step for the diagnosis of PPI. Both these tests are widely available, inexpensive, and have a rapid turnaround time in laboratories. The results should be interpreted with caution due to their relative lack of specificity. The sensitivity and specificity values for CRP are approximately 88 and 74%, respectively; while that of ESR is slightly lower at 75 and 70%, respectively. The combined ESR and CRP tests are 96% sensitive for ruling out PPI but the specificity of this combination is as low as 56%. Advanced imaging modalities may be used as a part of the diagnostic algorithm. However, they require expert interpretation and are limited by availability and high costs. When available they have high sensitivity and specificity but their routine use is not recommended and indications have to be individualised in the light of clinical presentation.

In the presence of high clinical suspicion, the clinician should plan synovial fluid analysis. This provides a synovial fluid white cell count with differential cell count, specimen for culture and possibility of analyzing other synovial fluid markers. It is important to note that failed metal-on-metal hip arthroplasties can give a falsely elevated synovial fluid cell count when using automated cell counters. This can be overcome by manually counting cell numbers. Synovial fluid should be directly into blood culture bottles, and antibiotics should be withheld at least 2 weeks prior to aspiration, whenever possible. Cultures also help establish the organism, virulence and sensitivities that help plan subsequent treatment algorithm.

Periprosthetic tissue biopsy provides valuable information in microbiological diagnosis and workup of PPI. Routine use of gram staining is not recommended due to poor sensitivity. However, frozen section may have some role especially when performed by a skilled pathologist. Tissue culture remains the gold standard for diagnosis despite false-positive and false-negative results. Whenever possible multiple samples should be obtained to aid interpretation. A threshold of 2 to 3 positive specimens yielding indistinguishable microorganisms has been recommended to improve sensitivity. Acute inflammation, evidenced by neutrophilic infiltrate on fixed or frozen tissue, is suggestive of PPI and is defined as the presence of at least 5 neutrophils per high-powered field, in at least 5 separate microscopic fields.

Sonication of removed prosthetic components is used to dislodge the biofilm and the associated bacteria from the surface of the implant. The fluid surrounding the implant can be used for culture or analysis.

PCR testing: Synovial fluid aspirate, periprosthetic tissue or sonicate fluid may be subject to molecular diagnosis to amplify genetic material and improve microbiological diagnosis of PPI. This technique has shown increased sensitivity in patients who had received antibiotics within 14 days before implant removal. Results have to carefully interpreted with due consideration for possibility of false positive results.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 91 - 91
1 Apr 2017
Haddad F
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The infected joint arthroplasty continues to be a very challenging problem. No test has 100% diagnostic accuracy for PPI and the treating surgeon must correlate the clinical and radiographic presentation with a combination of blood tests, synovial fluid analysis, microbiological and histopathological evaluation of periprosthetic tissue and intra-operative inspection to reach a definitive diagnosis. Diagnosis should begin with a high index of suspicion for new onset of pain or symptoms in well-functioning joints. Plain radiographs may identify osteolysis or early signs of implant failure and should be promptly investigated further for PPI.

Peripheral blood ESR and CRP remain the most widely used next step for the diagnosis of PPI. Both these tests are widely available, inexpensive, and have a rapid turnaround time in laboratories. The results should be interpreted with caution due to their relative lack of specificity. The sensitivity and specificity values for CRP are approximately 88 and 74%, respectively; while that of ESR is slightly lower at 75 and 70%, respectively. The combined ESR and CRP tests are 96% sensitive for ruling out PPI but the specificity of this combination is as low as 56%. Advanced imaging modalities may be used as a part of the diagnostic algorithm. However, they require expert interpretation and are limited by availability and high costs. When available they have high sensitivity and specificity but their routine use is not recommended and indications have to be individualised in the light of clinical presentation.

In the presence of high clinical suspicion, the clinician should plan synovial fluid analysis. This provides a synovial fluid white cell count with differential cell count, specimen for culture and possibility of analyzing other synovial fluid markers. It is important to note that failed metal-on-metal hip arthroplasties can give a falsely elevated synovial fluid cell count when using automated cell counters. This can be overcome by manually counting cell numbers. Synovial fluid should be directly into blood culture bottles, and antibiotics should be withheld at least 2 weeks prior to aspiration, whenever possible. Cultures also help establish the organism, virulence and sensitivities that help plan subsequent treatment algorithm.

Periprosthetic tissue biopsy provides valuable information in microbiological diagnosis and workup of PPI. Routine use of gram staining is not recommended due to poor sensitivity. However, frozen section may have some role especially when performed by a skilled pathologist. Tissue culture remains the gold standard for diagnosis despite false-positive and false-negative results. Whenever possible multiple samples should be obtained to aid interpretation. A threshold of 2 to 3 positive specimens yielding indistinguishable microorganisms has been recommended to improve sensitivity. Acute inflammation, evidenced by neutrophilic infiltrate on fixed or frozen tissue, is suggestive of PPI and is defined as the presence of at least 5 neutrophils per high-powered field, in at least 5 separate microscopic fields.

Sonication of removed prosthetic components is used to dislodge the biofilm and the associated bacteria from the surface of the implant. The fluid surrounding the implant can be used for culture or analysis.

PCR testing: Synovial fluid aspirate, periprosthetic tissue or sonicate fluid may be subject to molecular diagnosis to amplify genetic material and improve microbiological diagnosis of PPI. This technique has shown increased sensitivity in patients who had received antibiotics within 14 days before implant removal. Results have to carefully interpreted with due consideration for possibility of false positive results.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 45 - 45
1 Apr 2017
Haddad F
Full Access

Treatment of recurrent dislocation: approximately: 1/3 of failures (probably higher in the absence of a clear curable cause).

In the US: most popular treatment option: constrained liners with high redislocation and loosening rates in most reports. Several interfaces leading to various modes of failures.

In Europe: dual mobility cups (or tripolar unconstrained): first design Gilles Bousquet 1976 (Saint Etienne, France), consisting of a metal shell with a highly polished inner surface articulating with a mobile polyethylene insert (large articulation). The femoral head is captured into the polyethylene (small articulation) using a snap fit type mechanism leading to a large effective unconstrained head inside the metal cup. With dual mobility, most of the movements occur in the small articulation therefore limiting wear from the large polyethylene on metal articulation.

Contemporary designs include: CoCr metal cup for improved friction, outer shell coated with titanium and hydroxyapatite, possible use of screws to enhance primary stability (revision), cemented version in case of major bone defect requiring bone reconstruction.

Increased stability obtained through an ultra-large diameter effective femoral head increasing the jumping distance.

Dual mobility in revision for recurrent dislocation provided hip stability in more than 94% of the cases with less than 3% presenting redislocation up to 13-year follow-up. A series from the UK concerning 115 revisions including 29 revisions for recurrent dislocation reported 2% dislocation in the global series and 7% re-dislocation in patients revised for instability. A recent report of the Swedish hip arthroplasty register including 228 patients revised for recurrent dislocation showed 99% survival with revision for dislocation as the endpoint and 93% with revision for any reason as the endpoint.

One specific complication of dual mobility sockets: intra-prosthetic dislocation (ie: dislocation at the small articulation): often asymptomatic or slight discomfort, eccentration of the neck on AP radiograph, related to wear and fatigue of the polyethylene rim at the capturing are through aggressive stem neck to mobile polyethylene insert contact (3rd articulation). Risk factors include: large and aggressive femoral neck design implants, small head/neck ratio, skirted heads, major fibrosis and periprosthetic ossifications.

Current (over ?) use in France: 30% of primary THA, 60% in revision THA.

Proposed (reasonable) indications: primary THA at high risk for dislocation, revision THA for instability and/or in case of abductors deficiency, Undisputed indication: recurrent dislocation.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 9 - 9
1 Apr 2017
Haddad F
Full Access

A large body of the orthopaedic literature clearly indicates that the cement mantle surrounding the femoral component of a cemented total hip arthroplasty should be at least 2 mm thick. In the early 1970s, another concept was introduced and is still in use in France consisting of implanting a canal filling femoral component line-to-line associated with a thin cement mantle. This principle has been named the “French paradox”. An explanation to this phenomenon has been provided by in-vitro studies demonstrating that a thin cement mantle in conjunction with a canal filling stem was supported mainly by cortical bone and was subjected to low stresses. We carried out a study to evaluate the in-vivo migration patterns of 164 primary consecutive Charnley-Kerboull total hip replacements. All prosthesis in the current series combined an all-polyethylene socket and a 22.2 mm stainless steel femoral head. The monobloc double tapered (5.9 degrees) femoral component was made of 316L stainless steel with a highly polished surface (Ra = 0.04 μm), a quadrangular section, and a neck-stem angle of 130 degrees. The stem was available in six sizes with a stem length (shoulder to tip) ranging from 110 mm to 160 mm, and a neck length ranging from 24 mm to 56 mm. For each size, the femoral component was available in two to four different diameters to adapt the implant to the medullary canal. Hence the whole range comprised a total of 18 standard femoral components. The femoral preparation included removal of diaphyseal cancellous bone to obtain primary rotational and varus/valgus stability of the stem prior to the line-to-line cementation. We used the Ein Bild Roentgen Analyse Femoral Component (EBRA-FCA) method to assess the subsidence of the femoral component. At the minimum 15-year follow-up, 73 patients were still alive and had not been revised at a mean of 17.3 years, 8 patients had been revised, 66 patients were deceased, and 8 patients were lost to follow-up. The mean subsidence of the entire series was 0.63 ± 0.49 mm (0 – 1.94 mm). When using a 1.5 mm threshold, only four stems were considered to have subsided. With revision of either component for any reason as the endpoint, the cumulative survival rate at 17 years was 90.5 ± 3.2% (95% CI, 84.2% to 96.8%). With radiological loosening of the femoral component as the endpoint, the cumulative survival rate at 17 years was 96.8 ± 3.1% (95% CI, 93.2% to 100%). This study demonstrated that, in most cases, a highly polished double tapered stem cemented line-to-line does not subside up to 18-year follow-up.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_7 | Pages 104 - 104
1 Apr 2017
Haddad F
Full Access

Total knee arthroplasty (TKA) is widely accepted as a successful treatment option for the pain and limitation of function associated with severe joint disease. The ideal knee arthroplasty implant should provide reliable pain relief and normal levels of functional strength and range of motion. However, there are still a number of implant-specific problems following knee arthroplasty, such as irregular kinematics, polyethylene wear and poor range of motion.

MRI and cadaveric studies have highlighted important kinematics during movement of the native knee. In particular, flexion of the joint results in a phenomenon referred to as “roll back and slide”. This essentially describes posterior translation of the femur on the tibia which in turn has a two-fold biomechanical function: to increase the lever arm of the quadriceps and allow clearance of the femur from the tibia in deep flexion. During extension of the joint, the femur rolls forward increasing the lever arm of the hamstrings to act as a brake on hyperextension.

Additional rotation of the joint arises in the axial plane. This is attributed to the concave tibial plateau and relatively fixed meniscus on the medial compartment of the joint in comparison to a lateral convex plateau with a mobile meniscus. This asymmetry allows axial rotation of the lateral compartment over the medial compartment by up to 30 degrees. Subsequently, from extension to full flexion the tibia rotates internally on the femur and vice versa. The external rotation of the tibia on the femur that occurs during the terminal degrees of knee extension is often referred to as the “screw home mechanism” and results in tightening of both the cruciate ligaments locking the knee such that the tibia is in a position of maximum stability on the femur.

Numerous studies over the past two decades have characterised the in-vivo motions of knee replacements. Major conclusions from these studies are that the motion after knee arthroplasty generally does not replicate normal knee motions. In particular, many kinematic studies of unconstrained devices have demonstrated the femur sliding forwards rather than backwards with flexion. This paradoxical movement is also seen in many posterior cruciate retaining knees. This in turn has a negative outcome in range of movement, particularly in light of fluoroscopic studies highlighting strong positive correlations in weight-bearing flexion with femoral roll back. In contrast knee arthroplasties that retain both cruciate ligaments come closest to replicating normal knee motion and furthermore, provide greater stair climbing stability. It may therefore be presumed that this excessive AP motion in a well-designed prosthesis is attributed to a loss in the natural intrinsic stabilizing structures.

A number of studies to date have also highlighted close correlation between knee kinematics and functional strength. Generally, patients with knee replacement exhibit a significant loss of strength compared to normal. The common experimental findings is that knees with the highest intrinsic stability, whether provided by retained ligaments, conforming articular surfaces or post-cam substitution, exhibit the greatest functional strength in high-demand activities in TKA patients.

On the basis of this knowledge, it would be intuitive to choose a TKA design that attempts to restore natural knee joint stability. The medially conforming ‘ball and socket’ articulation of the medial tibio-femoral compartment is a design concept thought to provide stability through the complete arc of knee flexion. Clinical and biomechanical data from a number of centers suggests that this has been a successful evolution in TKA that will continue to benefit patients.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 20 - 20
1 Dec 2016
Haddad F
Full Access

Periprosthetic fractures after total hip arthroplasty lead to considerable morbidity in terms of loss of component fixation, bone loss and subsequent functional compromise. The prevention, early recognition and appropriate management of such fractures are therefore critical. The pathogenesis of periprosthetic factors is multi-factorial. There are a number of intrinsic patient influences such as poor bone stock, biomechanics and compliance. There are also a host of extrinsic factors over which the surgeon has more control. The key tenets for fracture avoidance include careful planning, identifying the risk, choosing the correct implant, understanding the anatomy, and using appropriate surgical technique.

There are a number of recognised risk factors for periprosthetic hip fractures The prevalence of intraoperative fractures during total hip arthroplasty is higher in the patient with osteopenia / osteoporosis. Other conditions causing increased bone fragility, such as osteomalacia, Paget's disease, osteopetrosis, and osteogenesis imperfecta are also at a higher risk of intraoperative fracture. The use of more and more press fit cementless components has also increased the number of periprosthetic femoral fractures because of the force required to obtain such a fit. Complex deformities of the proximal femur, particularly when associated with a narrow medullary canal, may also increase the risk of intraoperative fractures. Revision surgery is associated with a higher risk of intraoperative fracture than primary hip replacement surgery. These fractures typically occur during hip dislocation, cement extraction, or reaming through old cement. Other risk factors for postoperative femoral fractures following total hip replacement include loosening of the prosthesis with cortical bone loss, local osteolysis, stress risers within the cortex, such as old screw holes, the ends of plates, or impingement of a loose stem against the lateral femoral cortex.

The management of periprosthetic fractures requires appropriate preoperative imaging, planning and templating, the availability of the necessary expertise and equipment, and knowledge of the potential pitfalls so that these can be avoided both intraoperatively and in follow-up. There is a danger that these cases fall between the expertise of the trauma surgeon and that of the revision arthroplasty surgeon. The past two decades have afforded us clear treatment algorithms based on fracture location, component fixation and the available bone stock. We still nevertheless face the enduring challenge of an elderly population with a high level of comorbidity who struggle to rehabilitate after such injuries. Perioperative optimization is critical as we have seen prolonged hospital stays, high rates of systemic complications and a significant short term mortality in this cohort.

We have also been presented with new difficult fracture patterns around anatomic cementless stems and in relation to tapered cemented and cementless stems, as well as biologically challenging transverse or oblique fractures at the tip of a stem. In many cases, fixation techniques are biomechanically and biologically doomed to fail and intramedullary stability, achieved through complex revision is required.

The sequelae of periprosthetic fractures include the financial cost of fixation or revision surgery, the associated morbidity and mortality in an elderly frail population, the difficulty with mobilization if the patient cannot fully weight bear, and a poor functional outcome in a proportion of cases. The battle over which patients or fractures require fixation and which require revision surgery continues.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_22 | Pages 22 - 22
1 Dec 2016
Haddad F
Full Access

The approach to total hip arthroplasty (THA) should allow adequate visualization and access so as to implant in optimal position whilst minimizing muscle injury, maintaining or restoring normal soft tissue anatomy and biomechanics and encouraging a rapid recovery with minimal complications. Every surgeon who performs primary hip arthroplasties will expound the particular virtues of his or her particular routine surgical approach. Usually this approach will be the one to which the surgeon was most widely exposed to during residency training.

There is a strong drive from patients, industry, surgeon marketing campaigns, and the media to perform THA through smaller incisions with quicker recoveries. The perceived advantage of the anterior approach is the lack of disturbance of the soft tissues surrounding the hip joint, less pain, faster recovery with the potential for earlier return to work, shorter hospital stay and improved cosmetic results. The potential disadvantages include less visibility, longer operation time, nerve injuries, femoral fractures, malposition and a long learning curve for the surgeon (and his / her patients).

The anterior approach was first performed in Paris, by Robert Judet in 1947. The advantages of the anterior approach for THA are several. First, the hip is an anterior joint, closer to the skin anterior than posterior. Second, the approach follows the anatomic interval between the zones of innervation of the superior and inferior gluteal nerves lateral and the femoral nerve medial. Third, the approach exposes the hip without detachment of muscle from the bone.

The mini-incision variation of this exposure was developed by Joel Matta in 1996. He rethought his approach to THA and his goals were: lower risk of dislocation, enhanced recovery, and increased accuracy of hip prosthesis placement and leg length equality. This approach preserves posterior structures that are important for preventing dislocation while preserving important muscle attachments to the greater trochanter. The lack of disturbance of the gluteus minimus and gluteus medius insertions facilitates gait recovery and rehabilitation, while the posterior rotators and capsule provide active and passive stability and account for immediate stability of the hip and a low risk of dislocation.

A disadvantage of the approach is the fact that a special operating table with traction is required. Potential complications include intraoperative femoral and ankle fractures. These can be avoided through careful manipulation of the limb. If a femoral fracture occurs, the incision can be extended distally by lengthening the skin incision downward along the anterolateral aspect of the thigh, and splitting the interval between the rectus femoris and the vastus lateralis.

The choice of approach used to perform a primary THA remains controversial. The primary goals are pain relief, functional recovery and implant longevity performed with a safe and reproducible approach without complications. The anterior approach is promising in terms of hospital stay and functional recovery. Although recent studies suggest that component placement in minimally invasive surgery is safe and reliable, no long-term results have been published. Further follow-up and development is necessary to compare the results with the posterior approach as most of the positive data is based on comparisons with the anterolateral approach.

The proposed benefits of the anterior approach are not supported by the current available literature. The issues regarding the difficult learning curve, rate of complications, operative time, requirement for trauma tables and image intensifier should be taken into account by surgeons starting with the anterior approach in THA.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 29 - 29
1 Nov 2016
Haddad F
Full Access

Approximately 20% of patients undergoing primary unilateral total knee arthroplasty complain of severe pain in the contralateral knee, and 10% of patients who have had a primary total knee (TKA) undergo contralateral surgery within 1 year.

The number of patients suitable for primary TKA is rising, and so is the need for simultaneous bilateral TKA (BTKA) procedures. The advantages of single-stage BTKA include its low complication rates, high patient satisfaction, and cost-effectiveness. Others believe that there is increased morbidity and mortality.

The goal of reducing the exposure to repeated anaesthesia, total hospitalization and recovery time, and cost, while maintaining patient safety, is a laudable one. Our data suggest that bilateral TKA patients have a lower total operating time, use less pain medication, have a shorter hospital stay and lower overall treatment costs.

The cohort of patients selected for bilateral surgery in our unit is younger and has fewer comorbidities than unilateral controls. They have a high satisfaction rate and no increase in complication or readmission rates. We have seen a higher blood transfusion rate but no increase in cardiac, thromboembolic or septic complications.

The key to BTKA is patient selection and the implementation of efficient care and surgical pathways that includes a thorough pre-assessment, careful education and well-resourced aggressive post-operative physiotherapy. When appropriately applied, the benefits include a shorter overall recovery time and an accelerated return to everyday life and work.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 59 - 59
1 Nov 2016
Haddad F
Full Access

The infected joint arthroplasty continues to be a very challenging problem. Its management remains expensive, and places an increasing burden on health care systems. It also leads to a long and difficult course for the patient, and frequently a suboptimal functional outcome. The choice of a particular treatment program will be influenced by a number of factors. These include the acuteness or chronicity of the infection; the infecting organism(s), its antibiotic sensitivity profile and its ability to manufacture glycocalyx; the health of the patient; the fixation of the prosthesis; the available bone stock; and the particular philosophy and training of the surgeon.

For most patients, antibiotics alone are not an acceptable method of treatment, and surgery is necessary. The standard of care for established infection is two-stage revision with antibiotic loaded cement during the interval period and parental antibiotic therapy for six weeks. Single stage revision may have economic and functional advantages however. We have devised a protocol that dictates the type of revision to be undertaken based on host, organism and local factors.

Our protocol has included single stage revision using antibiotic loaded cement in both THA and TKA. This was only undertaken when sensitive organisms were identified pre-operatively by aspiration and appropriate antibiotics were available to use in cement. Patients with immunocompromise, multiple infecting organisms or recurrent infection were excluded. Patients with extensive bone loss that required allograft reconstruction or where a cementless femoral component was necessary were also excluded.

Our algorithm was validated first in the hip and extended to infected TKA in 2004. This protocol has now been applied in over 100 TKA revisions for infection between 2004 and 2009. Our single stage revision rate is now over 25%. We continue to see a lower reinfection rate in these carefully selected patients, with high rates of infection control and satisfaction and better functional and quality of life scores than our two-stage revision cases.

Whilst our indications are arbitrary and not based on specific biomarkers, we present excellent results for selective single stage exchange. A minimum three-year follow-up suggests that these patients have shorter hospital stays, higher satisfaction rates and better knee scores. An ongoing evaluation is in place. One-stage revision arthroplasty for infection offers potential clinical and economic advantages in selected patients.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_17 | Pages 80 - 80
1 Nov 2016
Haddad F
Full Access

The approach to total hip arthroplasty (THA) should allow adequate visualization and access so as to implant in optimal position whilst minimizing muscle injury, maintaining or restoring normal soft tissue anatomy and biomechanics and encouraging a rapid recovery with minimal complications. The direct anterior approach (DAA) for THA was first performed in Paris, by Robert Judet in 1947. This procedure has since been performed consistently by a small group of surgeons and has recently gained great popularity. Access to the hip can be safely performed with one or two assistants. The advantages of the anterior approach for hip arthroplasty are several. First, the hip is an anterior joint, closer to the skin anterior than posterior. Second, the approach follows the anatomic interval between the zones of innervation of the superior and inferior gluteal nerves lateral and the femoral nerve medial. Third, the approach exposes the hip without detachment of muscle from the bone. Care must be taken to avoid cutting the lateral femoral cutaneous nerve which runs over the fascia of the sartorius. The mini-incision variation of this exposure was developed by Joel Matta in 1996. He rethought his approach to hip arthroplasty and by abandoning the posterior approach and adopting the anterior approach his goals were: lower risk of dislocation, enhanced recovery, and increased accuracy of hip prosthesis placement and leg length equality. This approach preserves posterior structures that are important for preventing dislocation while preserving important muscle attachments to the greater trochanter. The lack of disturbance of the gluteus minimus and gluteus medius insertions facilitates gait recovery and rehabilitation while the posterior rotators and capsule provides active and passive stability and accounts for immediate stability of the hip and a low risk of dislocation. Using the anterior approach, patients are allowed to mobilise their hip freely. The gluteus maximus and tensor fascia latae muscles insert on the iliotibial band which joins them and form a ´hip deltoid´. Lack of disturbance of these abductors and pelvic stabilisers is another benefit of the anterior approach and accelerates gait recovery. The lateral femoral cutaneous nerve is at risk when the fascia is incised between the tensor fascia latae and the sartorius muscle. Damaging it may lead to a diminished sensation on the lateral aspect of the thigh and formation of a neuroma.

A disadvantage of the approach is the fact that a special operating table with traction is required. Potential complications include intra-operative femoral and ankle fractures. These can be avoided through careful manipulation of the limb. If a femoral fracture occurs, the incision can be extended distally along the anterolateral aspect of the thigh, and splitting the interval between the rectus femoris and the vastus lateralis. In obese or muscular patients, where visibility is in doubt, an increase of the incision length will give the surgeon the required view.

The choice of approach used to perform a primary THA remains controversial. The primary goal of a hip replacement is pain relief, functional recovery and implant longevity performed with a safe and reproducible approach without complications. The anterior approach is promising in terms of hospital stay and functional recovery. Although recent studies suggest that component placement in minimally invasive surgery is safe and reliable, no long-term results have been published. Further follow-up and development is necessary to compare the results with the posterior approach. The proposed benefits of with the DAA are not supported by the current available literature. The issues regarding the difficult learning curve, rate of complications, operative time, requirement for trauma tables and image intensifier should be taken into account by surgeons starting with the DAA in THA.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 42 - 42
1 Jun 2016
Volpin A Konan S Tansey R Haddad F
Full Access

Introduction

Acetabular revision surgery is becoming more prevalent with an estimated increase of 137% by 2030. It is challenging surgery especially in the presence of deficient bone loss. Several techniques of acetabular reconstruction are used world-wide. The greater the bone loss (Paprosky Type IIIA and IIIB, and AAOS Classification of Acetabular Bone Loss Type 3 and 4) the more complex are the reconstruction methods. There is however, insufficient literature comparing the contemporary techniques of revision acetabular reconstruction and their outcomes.

Objectives

The purpose of this study was to systematically review the literature and to report clinical outcomes and survival of contemporary acetabular revision arthroplasty techniques (tantalum metal (TM) systems, uncemented revision jumbo cups, reinforced devices such as cages and rings, oblong cups and custom-made triflange cups). We specifically looked at outcomes when reconstruction was undertaken in the presence of bone loss.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_15 | Pages 17 - 17
1 Dec 2015
George D Volpin A Scarponi S Drago L Haddad F Romano C
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The best surgical modality for treating chronic periprosthetic shoulder infections has not been established, with a lack of randomised comparative studies. This systematic review compares the infection eradication rate and functional outcomes after single- or two-stage shoulder exchange arthroplasty, to permanent spacer implant or resection arthroplasty.

Full-text papers and those with an abstract in English published from January 2000 to June 2014, identified through international databases, were reviewed. Those reporting the success rate of infection eradication after a single-stage exchange, two-stage exchange, resection arthroplasty or permanent spacer implant were included, with a minimum follow-up of 6 months and sample size of 5 patients.

Eight original articles reporting the results after resection arthroplasty (n = 83), 6 on single-stage exchange (n = 75), 13 on two-stage exchange (n = 142) and 8 papers on permanent spacer (n = 68) were included.

The average infection eradication rate was 86.7% at a mean follow-up of 39.8 months (SD 20.8) after resection arthroplasty, 94.7% at 46.8 months (SD 17.6) after a single-stage exchange, 90.8% at 37.9 months (SD 12.8) after two-stage exchange, and 95.6% at 31.0 months (SD 9.8) following a permanent spacer implant. The difference was not statistically significant.

Regarding functional outcome, patients treated with single-stage exchange had statistically significant better postoperative Constant scores (mean 51, SD 13) than patients undergoing a two-stage exchange (mean 44, SD 9), resection arthroplasty (mean 32, SD 7) or a permanent spacer implant (mean 31, SD 9) (p=0.029). However, when considering studies comparing pre- and post-operative Constant scores, the difference was not statistically significant.

This systematic review failed to demonstrate a clear difference in infection eradication and functional improvement between all four treatment modalities for established periprosthetic shoulder infection. The relatively low number of patients and the methodological limitations of the studies available point out the need for well designed multi-center trials to further assess the best treatment option of peri-prosthetic shoulder infection.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 4 - 4
1 Nov 2015
Osman K Panagiotidou A Meswania J Skinner J Hart A Haddad F Blunn G
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Introduction

Recent studies on large diameter femoral head hip replacements have implicated the modular taper junction as one of the significant sources of wear and corrosion products and this has been attributed to increased torque and bending on the taper interface. The aim of this study was to assess the effect of frictional torque and bending moment on fretting corrosion at the taper junction and to investigate whether different material combinations also had an effect.

Patients/Materials & Methods

We examined 1) Cobalt Chromium (CoCr) heads on CoCr stems 2) CoCr heads on Titanium alloy (Ti) stems and 3) Ceramic heads on CoCr stems. In test 1 increasing torque was imposed by offsetting the femoral stem in the anterior posterior plane in increments of 0 mm, 4 mm, 6 mm and 8 mm where the force generated was equivalent to 0Nm, 9Nm, 14Nm and 18Nm. In Test 2 we investigated the effect of increasing bending moment by offsetting the application of axial load from the midline in the medial-lateral (ML). Offset increments equivalent to +0, +7 and +14 heads were used. For each test we used n=3 for each different material combination.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_13 | Pages 28 - 28
1 Nov 2015
Haddad F
Full Access

Total knee replacement (TKR) is considered the “gold standard” treatment for advanced osteoarthritis (OA) of the knee with good survivorship and functional outcomes. However up to 20% of patients undergoing TKR may have unicompartmental disease only. Treatment options for medial compartment arthritis can include both unicompartmental knee replacements (UKR) and TKR. While some surgeons favor TKR with a proven track record, others prefer UKR due to more normal joint kinematics, better proprioception and better motion. There is also a higher rate of return to sports amongst patients with UKR compared to TKR.

When considering all knee procedures, partial knee replacements account for 7–9%, primary TKRs for 83–88%, and revision knee replacements for 5–8%. Unicompartmental Knee Replacements comprise more than 90% of all partial knee replacement procedures. Proponents of UKR cite as advantages the preservation of normal knee kinematics, lower peri-operative morbidity, blood loss and infection risk compared with TKRs, as well as accelerated patient rehabilitation and recovery. However, partial knee replacements have a higher rate of revision than TKRs. This may be partly because they are inserted in patients with higher expectations, and partly because they are easier to revise. As a result, the volume of UKRs implanted has diminished over time and continues to decline.

We compared patient reported outcomes, satisfaction and perception of normality of the knee post-operatively between UKR and TKR. A single unit and single surgeon series of patients were recruited. Data was collated for 68 well-matched patients with more than 24 months follow-up. UKR was undertaken in patients with isolated medial compartment osteoarthritis; stable ACL and less than grade 3 lateral patellar changes of the Outerbridge classification. TKR was undertaken for the rest. The patients were assessed with validated knee scores including the Total Knee Function Questionnaire (TKFQ) which focuses on recreational and sporting outcomes as well as activities of daily living (ADL). Patient satisfaction and perception of knee normality was measured on a visual analogue scale.

Thirty-four patients with a TKR and 34 patients with a UKR were analyzed. The average ages in the TKR and UKR groups were 69.25 and 67.26 years, respectively. The patients were well-matched for demographics and had equivalent pre-operative morbidities and scores. The UKR group had better WOMAC (p=0.003), SF36 (physical: p<0.001 mental: p=0.25), Oxford knee (p<0.001) and Knee Society scores (p=0.002, function: p<0.001). The UKR group showed better outcomes in the TKFQ including exercise and sport (p= 0.02), movement and lifestyle (p=0.02) and the ADL (p=0.002). There was, however, no difference in patient satisfaction scores (p=0.41) and perception of how normal the knee felt between the two groups (p=0.99).

A UKR procedure confers better functional outcome in terms of recreation and sport compared to TKR procedures. While UKR is an appropriate choice in the elderly yet active patient with unicompartmental knee arthritis, satisfaction is similar to that of patients with a TKR reflecting higher pre-operative expectations. We believe that in appropriate centers, the UKR procedure is associated with excellent outcomes. UKR should have a secure place in the knee arthroplasty armamentarium provided current knowledge regarding patient selection and surgical technique is followed.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_13 | Pages 100 - 100
1 Nov 2015
Haddad F
Full Access

Introduction

The reconstructive hip surgeon is commonly faced with complex cases where severe bone loss makes conventional revision techniques difficult or impossible. This problem is likely to increase in future, as there is a good correlation between the degree of bone loss seen and number of previous total hip operations. In such situations, one alternative is the use impaction allografting with cement. This has captured the attention of the orthopaedic community because of its potential for reconstituting femoral bone stock.

History

The first clinical reports of impaction allografting on the femoral side were in relation to revision with cementless stems. The use of morselised bone with cement on the femoral side was first reported by the Exeter group.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 20 - 20
1 Nov 2015
Tansey R Benjamin-Laing H Jassim S Liekens K Shankar A Haddad F
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Introduction

Hip and groin injuries are common in athletes participating in high level sports. Adductor muscle tendon injuries represent a small but important number of these injuries. Avulsion injuries involving tendons attaching to the symphysis pubis have previously been described and can be managed both operatively and non-operatively.

The aim is to describe a rare variant of this injury; complete avulsion of the adductor sleeve complex including adductor longus, pectineus and rectus abdominus. A surgical technique is then outlined which promotes a full return to pre-injury level of sporting activity.

Patients/Materials & Methods

Fifteen high level athletes with an MRI confirmed acute adductor complex avulsion injury (6–34 days) were identified from the institution's sports injury database over a 10 year period. All underwent surgical repair. The operative procedure comprised anatomical attachment of the avulsed tissues in all cases (plus mesh reinforcement of the inguinal wall in 7 patients). All underwent a standard format of rehabilitation which was then individualised to be sport specific.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_1 | Pages 3 - 3
1 Feb 2015
Haddad F
Full Access

A multitude of different bearing combinations exist to recreate the artificial hip joint. To date, there is no particular ‘gold-standard’ total hip arthroplasty (THA) couple since none is faultless. Strategies to improve performance are aimed either at modifying the shape and design of components or their material properties. Wear particle generation is now well recognised as a cause of aseptic loosening which consistently features amongst the most common indication for revision THA and thus minimising wear lies at the cornerstone of developing bearing couples. However, history has shown the use of supposed newer and improved materials have not been without occasional catastrophic failure. Hard-on-hard bearings are theoretically more resistant to wear but component fracture and squeaking has been witnessed with ceramic-on-ceramic articulations whilst metal-on-metal articulations have been plagued by reports of pseudotumor and ALVAL formation. This has all led to resurgence in the hard-on-soft couple.

More recently, corrosion at taper junctions has been identified as a significant factor in hip arthroplasty failure. Femoral head materials, surface changes or coatings may therefore have an increasing role to play.

In 2005, a multi-center, prospective, assessor and patient-blinded, randomised control trial was initiated. This was designed as a three armed study with either cobalt-chrome or oxidized zirconium femoral heads articulating against highly cross-linked polyethylene (XLPE) liners and oxidized zirconium articulating against ultra-high molecular weight polyethylene (UHMWPE). Early reports that XLPE was significantly superior to UHMWPE when coupled with cobalt-chrome meant no patient involved in the study was approved to receive a couple of cobalt-chrome and UHMWPE since it was deemed to be a high wear group.

We hypothesised that oxidized zirconium femoral heads would produce less linear wear than cobalt- chrome femoral heads at mid-term evaluation, whilst maintain similar outcomes when recording WOMAC, SF-36 and pain scores, and complication rates. All three groups were statistically comparable preoperatively and at five years when measuring normalised WOMAC, SF-36 and pain scale scores; all groups showed a statistically significant improvement in scores from baseline compared to at five years (p<0.001).

There was no significant difference in mean femoral head penetration when either oxidized zirconium or cobalt-chrome where articulated with XLPE (p=0.1533) but a significant difference in mean femoral head penetration was observed between the group that had used UHMWPE and both the other groups which had used XLPE (p<0.001). There were no hips in which either acetabular or femoral osteolysis was observed.

We have demonstrated that oxidized zirconium femoral heads are safe with low rates of wear when coupled with XLPE. However at five year follow-up, it appears that the choice of material of the acetabular bearing is more important than the choice of femoral head bearing. Further follow-up is needed in order to see if femoral head choice leads to a difference in outcome beyond 5 years as laboratory data suggests. Moreover the potential reduction of corrosion with ceramic or oxidized zirconium heads may yet also prove to be significant.

It is likely that current and future data will lead us away from the use cobalt chrome heads towards alternatives that are less likely to be associated with corrosion or wear and osteolysis.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_1 | Pages 54 - 54
1 Feb 2015
Haddad F
Full Access

Introduction:

The reconstructive hip surgeon is commonly faced with complex cases where severe bone loss makes conventional revision techniques difficult or impossible. This problem is likely to increase in future, as there is a good correlation between the degree of bone loss seen and number of previous total hip operations. In such situations, one alternative is the use of impaction allografting with cement.

History:

The first clinical reports of impaction allografting on the femoral side were in relation to revision with cementless stems. The use of morselised bone with cement on the femoral side was first reported by the Exeter group.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_1 | Pages 24 - 24
1 Feb 2015
Haddad F
Full Access

The advantages of modularity in both primary and revision hip surgery are well documented, and have been at the heart of innovation in hip implant design over the last two decades. There have been significant developments in modularity proximally at the head-neck junction, more distally with modular necks and at mid-stem level, notable for complex revisions. Modularity allows us to address version, length and offset issues and to restore optimal hip biomechanics. There are, however, increasing clinical concerns associated with the failure of taper junctions. The use of large femoral heads and modular stems are now considered major risk factors for taper corrosion. Recent studies have shown an 8–9% early revision rate of one modular neck design due to pain and adverse local tissue reaction. I will summarise our laboratory and retrieval data on taper design and tribology in order to put in perspective the clinical use of modularity in hip arthroplasty.

Modular junctions rely on a frictional interlock. The engagement obtained and resulting micromotion is strongly influenced by taper size, taper length/engagement, material, surface finish, neck length and offset. In our quest for thinner femoral necks, greater offsets and bigger femoral heads, we have inadvertently created an environment that can generate fretting corrosion at modular junctions and leads to premature implant failure.

Our work demonstrates that increasing torque and bending moment leads to increased susceptibility to fretting corrosion at the modular taper interface of total hip replacements. This is particularly relevant with the increasing use of larger diameter femoral heads that produce higher torques. It also identifies surface area and surface finish as important factors in wear and corrosion at the modular interface of total hip replacements. Critically, the combination of these factors can lead to extensive corrosion at the interface.

Surgical technique is also important. Higher impaction loads on clean, dry surfaces result in greater contact length and extraction forces, which may influence micromotion.

It is critical in future that all innovation is introduced in a systematic gradual fashion so that we do not fall into similar traps again. The unintended consequences of minor changes in design may have a massive effect on outcomes. Our findings suggest that it may be possible to continue to employ the advantages of modularity in hip surgery whilst avoiding some of the pitfalls that have led to the failure of some modular systems.

Understanding the key design and surgical factors that drive the performance of taper junctions is vital for the surgical community. There is a body of knowledge that supports appropriate taper use / modularity to help surgeons deal with complex situations. We must be careful not throw the baby out with the bathwater.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 45 - 45
1 Jul 2014
Vanhegan I Coathup M McCarthy I Haddad F Blunn G
Full Access

Summary Statement

Proximal femoral bony deficits present a surgical and biomechanical challenge to implant longevity in revision hip arthroplasty. This work finds comparable primary stability when a distally fixing tapered fluted stem was compared with a conical design in cadaveric tests.

Introduction

Proximal bony deficits complicate revision hip surgery and compromise implant survival. Longer distally fixing stems which bypass such defects are therefore required to achieve stability compatible with bony ingrowth and implant longevity.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_12 | Pages 93 - 93
1 Jul 2014
Haddad F
Full Access

Introduction

The reconstructive hip surgeon is commonly faced with complex cases where severe bone loss makes conventional revision techniques difficult or impossible. This problem is likely to increase in future, as there is a good correlation between the degree of bone loss seen and number of previous total hip operations. In such situations, one alternative is the use impaction allografting with cement. This has captured the attention of the orthopaedic community because of its potential for reconstituting femoral bone stock.

History

The first clinical reports of impaction allografting on the femoral side were in relation to revision with cementless stems. The use of morselised bone with cement on the femoral side was first reported by the Exeter group.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_12 | Pages 50 - 50
1 Jul 2014
Haddad F
Full Access

The infected joint arthroplasty continues to be a very challenging problem. Its management remains expensive, and places an increasing burden on health care systems. It also leads to a long and difficult course for the patient, and frequently a suboptimal functional outcome. The choice of a particular treatment program will be influenced by a number of factors. These include the acuteness or chronicity of the infection; the infecting organism(s), its antibiotic sensitivity profile and its ability to manufacture glycocalyx; the health of the patient; the fixation of the prosthesis; the available bone stock; and the particular philosophy and training of the surgeon.

For most patients, antibiotics alone are not an acceptable method of treatment, and surgery is necessary. The standard of care for established infection is two-stage revision with antibiotic-loaded cement during the interval period and parental antibiotic therapy for six weeks. Single-stage revision may have economic and functional advantages however. We have devised a protocol that dictates the type of revision to be undertaken based on host, organism and local factors.

Our protocol has included single-stage revision using antibiotic-loaded cement in both THA and TKA. This was only undertaken when sensitive organisms were identified pre-operatively by aspiration and appropriate antibiotics were available to use in cement. Patients with immunocompromise, multiple infecting organisms or recurrent infection were excluded. Patients with extensive bone loss that required allograft reconstruction or where a cementless femoral component was necessary were also excluded.

Our algorithm was validated first in the hip and extended to infected TKA in 2004. This protocol has now been applied in over 100 TKA revisions for infection between 2004 and 2009. Our single-stage revision rate is now over 25%. We continue to see a lower reinfection rate in these carefully selected patients, with high rates of infection control and satisfaction and better functional and quality of life scores than our two-stage revision cases.

Whilst our indications are arbitrary and not based on specific biomarkers, we present excellent results for selective single-stage exchange. A minimum three-year follow up suggests that these patients have shorter hospital stays, higher satisfaction rates and better knee scores. An ongoing evaluation is in place. One-stage revision arthroplasty for infection offers potential clinical and economic advantages in selected patients.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 5 - 5
1 May 2014
Haddad F
Full Access

The advantages of modularity in both primary and revision hip surgery are well documented, and have been at the heart of innovation in hip implant design over the last two decades. Modularity allows us to address version, length and offset issues and to restore optimal hip biomechanics. There are, however, increasing clinical concerns associated with the failure of taper junctions. The use of large femoral heads and modular stems are now considered major risk factors for taper corrosion. I will summarise our laboratory and retrieval data on taper design and tribology in order to put in perspective the clinical use of modularity in hip arthroplasty.

Modular junctions rely on a frictional interlock. The engagement obtained and resulting micromotion is strongly influenced by taper size, taper length/engagement, material, surface finish, neck length and offset. In our quest for thinner femoral necks, greater offsets and bigger femoral heads, we have inadvertently created an environment that can generate fretting corrosion at modular junctions and leads to premature implant failure.

An inverted hip replacement setup was used similar to the specified ASTM test (ASTM F1875–98). Twenty-eight millimeter Cobalt Chrome (CoCr) femoral heads were coupled with either full length (standard) or reduced length (mini) 12/14 Titanium (Ti) stem tapers. These Ti stem tapers had either a rough or smooth surface finish whilst all the head tapers had a smooth finish. Wear and corrosion of taper surfaces were compared following a 10 million loading cycle. The surface roughness parameters on the head taper were significantly increased when the head-stem contact area was reduced. Similarly, the surface roughness parameters on the head taper were significantly increased when rough stem tapers were used. With rough male tapers the CoCr head taper became circumferentially ridged with distinct areas of pitting corrosion similar to that seen on some retrievals. In these tests similar surface morphology to that on retrieved femoral heads was seen on the female head taper.

Thirty-six millimeter CoCr femoral heads were also coupled with either a CoCr or Ti stem with 12/14 tapers all with smooth finish. Increasing perpendicular horizontal offsets in the sagittal plane created incremental increases in torque. A proportional relationship between torque and corrosion was observed for both CoCr-CoCr and CoCr-Ti material combinations.

In-vitro studies were used to evaluate the role of: taper size, angle mismatch, surface finish, and manufacturing tolerances on taper engagement. In-vitro loading analysis was performed to determine the bearing friction experienced by the taper connection. The component materials analysed were CoCr and Ti for stem design and CoCr/CoCr, ceramicized metal/CoCr, and CoCr/Ti for head/neck tapers. The high performance combinations included tapers with larger diameters, rougher surface finish, tighter tolerances and a proximal locking location. Loading studies demonstrate a 15 – 31% reduction in frictional torque (for 28, 36 and 40mm head sizes) using the ceramicized metal/XLPE couples compared to CoCr/XLPE couples.

Retrieval studies were conducted to assess taper corrosion using the Goldberg system and SEM analysis. Two hundred-nine taper surfaces, with in-vivo time varying from 1 week and 10 years, were analysed showing that ceramicized metal femoral heads have a lower corrosion score compared to CoCr femoral heads.

Understanding the key design and surgical factors that drive the performance of taper junctions is vital for the surgical community. There is a body of knowledge that supports appropriate taper use / modularity to help surgeons deal with complex situations. We must be careful not throw the baby out with the bathwater.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 66 - 66
1 May 2014
Haddad F
Full Access

The infected joint arthroplasty continues to be a very challenging problem. Its management remains expensive, and places an increasing burden on health care systems. It also leads to a long and difficult course for the patient, and frequently a sub optimal functional outcome. The choice of a particular treatment program will be influenced by a number of factors. These include the acuteness or chronicity of the infection; the infecting organism(s), its antibiotic sensitivity profile and its ability to manufacture glycocalyx; the health of the patient; the fixation of the prosthesis; the available bone stock; and the particular philosophy and training of the surgeon.

For most patients, antibiotics alone are not an acceptable method of treatment, and surgery is necessary. The standard of care for established infection is two stage revision with antibiotic loaded cement during the interval period and parental antibiotic therapy for six weeks. Single stage revision may have economic and functional advantages however. We have devised a protocol that dictates the type of revision to be undertaken based on host, organism and local factors.

Our protocol has included single stage revision using antibiotic loaded cement in both THA and TKA. This was only undertaken when sensitive organisms were identified preoperatively by aspiration and appropriate antibiotics were available to use in cement. Patients with immunocompromise, multiple infecting organisms or recurrent infection were excluded. Patients with extensive bone loss that required allograft reconstruction or where a cementless femoral component was necessary were also excluded.

Our algorithm was validated first in the knee and extended to infected TKA in 2004. This protocol has now been applied in over 100 TKA revisions for infection between 2004 and 2009. Our single stage revision rate is now over 25%. We continue to see a lower reinfection rate in these carefully selected patients, with high rates of infection control and satisfaction and better functional and quality of life scores than our two stage revision cases.

Whilst our indications are arbitrary and not based on specific biomarkers, we present excellent results for selective single stage exchange. A minimum three year follow-up suggests that these patients have shorter hospital stays, higher satisfaction rates and better knee scores. An ongoing evaluation is in place. One stage revision arthroplasty for infection offers potential clinical and economic advantages in selected patients.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 53 - 53
1 May 2014
Haddad F
Full Access

The reconstructive hip surgeon is commonly faced with complex cases where severe bone loss makes conventional revision techniques difficult or impossible. This problem is likely to increase in future, as there is a good correlation between the degree of bone loss seen and number of previous total hip operations. In such situations, one alternative is the use impaction allografting with cement. This has captured the attention of the orthopaedic community because of its potential for reconstituting femoral bone stock.

The first clinical reports of impaction allografting on the femoral side were in relation to revision with cementless stems. The use of morsellised bone with cement on the femoral side was first reported by the Exeter group. The great enthusiasm with which this technique has been received is related to its biological potential to increase bone stock. The rapid revascularisation, incorporation and remodelling of morsellised compacted cancellous allograft differs dramatically from structural allografting where bone ingrowth usually is limited to 2–3mm. Histological evidence for bony reconstitution has been presented from postmortem retrievals, and from biopsies at the time of trochanteric wire removal.

The size of the bone chips used as morsellised allograft is important. The graft behaves as a friable aggregate and its resistance to complex forces depends on grading, normal load and compaction. It is recommended that particles of 3–5mm in diameter make up the bulk of the graft. A bone slurry, such as that produced by blunted bone mills, or by the use of acetabular reamers or high speed burrs would not give satisfactory stability. A wide range of particle sizes is recommended in order to achieve the greatest stability. Future considerations will include the potential for either adding biomaterials to the allograft, or ultimately substituting it completely.

A satisfactory cement mantle is required to ensure the longevity of any cemented stem. The primary determinant of cement mantle thickness is the differential between the graft impactors and the final stem. All femoral impaction systems require careful design to achieve a cement mantle that is uninterrupted in its length and adequate in its thickness.

The technique of impaction allografting on the femoral side was first and most successfully reported using a highly polished stem with a double tapered geometry and no collar. It is thought to be ideal for this technique as it can subside within the cement mantle, thus generating hoop stresses on the cement which creeps, potentially maintaining physiological loads on the supporting bone. The extension of this technique to other stems has led to some controversy. Confounding factors such as surgical technique, the impaction system available, the type and size of allograft bone used, and the extent of the pre-operative bone loss, will undoubtedly continue to influence such comparisons. It appears that the exact stem configuration may not be as critical as its surface finish, the amount of graft impaction possible and the cement mantle produced.

Impaction allografting is the only technique currently available that reverses the loss of bone stock seen in a revision hip arthroplasty. Moreover, this technique does not sacrifice host tissue, and could facilitate further surgery. Impaction allografting, performed with great attention to detail using appropriate equipment, represents an exciting reconstructive solution for contained femoral defects. Its role in larger and combined defects remains open to scrutiny. Careful observation and cautious optimism are necessary as further refinements may well improve the predictability of the clinical results and expand the indications for this important addition to the armamentarium of the revision surgeon.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 20 - 20
1 May 2014
Haddad F
Full Access

Periprosthetic fractures in total hip arthroplasty lead to considerable morbidity in terms of loss of component fixation, loss of bone and subsequent functional deficits. We face an epidemic of periprosthetic fractures as the number of cementless implants inserted continues to rise and as the number of revisions continues to increase. The management of periprosthetic fractures requires careful preoperative imaging, planning and templating, the availability of the necessary expertise and equipment, and knowledge of the potential pitfalls so that these can be avoided both intra-operatively and in follow-up. There is a danger that these cases fall between the expertise of the trauma surgeon and that of the revision arthroplasty surgeon.

The past decade has afforded us clear treatment algorithms based on fracture location, component fixation and the available bone stock. We still nevertheless face the enduring challenge of an elderly population with a high level of comorbidity who struggle to rehabilitate after such injuries. Perioperative optimisation is critical as we have seen prolonged hospital stays, high rates of systemic complications and a significant short term mortality in this cohort.

We have also been presented with new difficult fracture patterns around anatomic cementless stems and in relation to tapered cemented and cementless stems. In many cases, fixation techniques are biomechanically and biologically doomed to fail and intramedullary stability, achieved through complex revision is required.

The treatment of unstable peri-prosthetic femur fractures can be technically challenging due to the weak non-supportive bone stock. We have seen an increase in the frequency of Type B3 fractures that require complex reconstruction with modular tapers, interlocking implants and proximal femoral replacements. Our reconstructive practice has evolved; the aims of femoral reconstruction include rotational and axial stability of the stem, near normal hip biomechanics and preserving as much femoral bone as possible. The advent of modular prostheses that gain distal fixation but have proximal options has extended the scope of this type of fixation. We now favor modular tapered stems that afford us the opportunity to reconstruct such femora whilst attempting to preserve the proximal bone. In effect, distal cone or taper fixation provides the initial stability required for the procedure to be successful but the proximal modular implant subsequently load shares to decrease stress shielding, distribute stress more evenly through the femur and minimise the risk of stem fracture. Such systems provide the intraoperative versatility that these cases require. The use of interlocking stems with coated ingrowth surfaces offers a relatively appealing solution for some complex fractures and avoids the complications that would be associated with unstable fixation or resection of the proximal femur.

Periprosthetic acetabular fractures are also increasingly recognised. This is in part due to the popularity of press fit components, which increase fracture risk both at the time of insertion and later due to medial wall stress shielding and pelvic osteolysis, and partly due to the increasing frequency of severe defects encountered at the time of revision surgery. These can present a very difficult reconstructive challenge and may require porous metal, cup-cage or custom reconstruction.

Periprosthetic fractures continue to cause problems worldwide. The sequelae of periprosthetic fractures include the financial cost of fixation or revision surgery, the associated morbidity and mortality in an elderly frail population, the difficulty with mobilisation if the patient cannot fully weight bear and a poor functional outcome in a proportion of cases. The battle over which patients or fractures require fixation and which require revision surgery continues.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 188 - 188
1 Dec 2013
Vanhegan I Coathup M McCarthy I Haddad F Blunn G
Full Access

Introduction

Revision hip arthroplasty is a technically challenging operation as proximal bony deficits preclude the use of standard implants. Longer distally fixing stems are therefore required to achieve primary stability.

Aims

This work aims to compare the primary stability and biomechanical properties of a new design of tapered fluted modular femoral stem (Redapt®, Smith & Nephew) to that of a conical fluted stem (Restoration®, Stryker). It is hypothesized that the taper will provide improved rotational stability under cyclical loading.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 364 - 364
1 Dec 2013
Kallala R Nizam I Haddad F
Full Access

Introduction:

Periprosthetic joint infection (PJI) is a devastating diagnosis that carries a significant rate of associated mortality and places a large burden on health care systems. Treatment protocols often include combined intravenous antibiotics and staged revision surgery with locally-delivered antibiotics via PMMA cement spacers and/or beads. One disadvantage of PMMA is the need for later removal. Antibiotic releasing Calcium Sulphate beads (CaSO4) have had promising results in revision joint surgery and are absorbable, making later removal unnecessary. We report on use in a tertiary referral centre in the UK and present our initial findings.

Methods & Results:

CaSO4 beads containing 1 gram of Vancomycin and 240 mg of tobramycin per 10 cc was implanted in 12 patients between August 2012 and December 2012, all having undergone revision joint surgery for PJI. Of these patients; 7 were men and 5 women, mean age was 57 years (range 39–72) with a mean ASA grade of 2 (1–4). Indications were infected Total Hip Replacement (n = 7), infected Total Knee Replacement (n = 4) and infected metal on metal hip resurfacing (n = 1). Three procedures were emergencies, with the remainder being semi-elective procedures. One patient had single-stage revision THR. At latest follow up 10 patients had made a full recovery, with normal function and inflammatory markers. Two patients were awaiting a second stage revision procedure. Mean follow up was 2 months (1–4).


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 473 - 473
1 Dec 2013
Panagiotidou A Bolland B Meswania J Skinner J Haddad F Hart A Blunn G
Full Access

Introduction:

High failure rates with large diameter, metal on metal hip replacements have highlighted a potential issue with the head/stem taper junction as one of the significant sources of metal ion release. Postulated reasons as to why this may be such a problem with large head metal on metal hip replacements is due to the increased torque achieved by the larger head size. This may be responsible for applying greater micromotion between the head and stem taper and consequently greater amounts of fretting corrosion. The aim of this study was to perform short term in vitro electrochemical tests to assess the effect of increasing head diameter and torque on the fretting corrosion susceptibility of the head/stem taper interface and to investigate its effect on different material combinations.

Methods:

36 mm Cobalt Chrome (CoCr) femoral heads were coupled with either a CoCr or Titanium (Ti) stem with 12/14 tapers, all with a smooth surface finish. Increasing perpendicular horizontal offsets in the sagittal plane created incremental increases in torque. Offset increments of 0 mm, 5.4 mm and 7.5 mm were selected (Figure 1) to simulate the torque force equivalent to 9 Nm, 12 Nm and 17 Nm. An inverted hip replacement setup was used (ASTM F1875-98) (Figure 2). Components were statically loaded at 0 kN and 2.3 kN prior to sinusoidal cyclic loading and electrochemical testing. Mean & fretting currents were calculated every 50 cycles up to a maximum of 1000 cycles of sinusoidal cyclic loading at 3 Hz along with the Overall Mean Current (OMC), Overall Mean Fretting Current (OMFC) and Overall Current change (OCC).


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 96 - 96
1 Dec 2013
Kallala R Ibrahim M Haddad F
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Revision surgery for total knee replacement is a complex procedure, carrying an increased risk for the patient and cost for hospitals. As well as increased cost of peri-operative investigations, blood transfusions, surgical instrumentation, implants and theatre time, there is a well documented increased length of stay (LOS), accounting for the majority of actual costs associated with surgery.

We compared revision surgery for infection vs. other causes (aseptic loosening, dislocation, mal-alignment). Clinical, demographic and economic data were obtained for 180 consecutive revision total knee replacements performed at a tertiary referral centre between 2003 and 2012. Actual costs and National Health Service tariffs were compared per patient and mean difference calculated.

Mean age was 66 years (range 17–87) with 62 male and 117 female patients. Mean LOS for aseptic cases was 10 days (range 1–62) and 20 days (range 4–103) for infection. Mean cost difference in aseptic cases (n = 125) was £−933 (SD = £12,204), and £−3907 (SD = £7,256) for infection (n = 54).

Surgery for infection was associated with increased operating times, blood loss and complications compared to revision for aseptic causes. LOS for infection was on average double that for aseptic cases (p < 0.05). Current NHS tariffs do not fully reimburse the increased costs associated with providing a revision knee surgery service, with even greater cost incurred by the treating hospital for infected cases. These losses may negatively influence the provision of revision surgery in the NHS.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 231 - 231
1 Dec 2013
Ayub A Richards T Haddad F
Full Access

AIM:

Preoperative anemia in patients undergoing elective total knee arthroplasty has been associated with increased allogeneic blood transfusion therapy and increased rates of in hospital morbidity, which often leads to a longer length of hospital stay. We measured the prevalence of anaemia among patients attending pre-admission clinic before elective major joint arthroplasty.

METHODS:

Retrospectively, a randomized sample of all patients undergoing total hip arthroplasty between Dec 2009 and June 2010 were included. The computerized laboratory results were analysed for anaemia as defined by the local reference range (<11.5g/dL for females, <13g/dL for males). Patients were reviewed 6 weeks post operatively and range of flexion and extension was documented.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 60 - 60
1 May 2013
Haddad F
Full Access

The principles of acetabular reconstruction include the creation of a stable acetabular bed, secure prosthetic fixation with freedom of orientation, bony reconstitution, and the restoration of a normal hip centre of rotation with acceptable biomechanics.

Acetabular impaction grafting, particularly with cemented implants, has been shown to be a reliable means of acetabular revision. Whilst our practice is heavily weighted towards cementless revision of the acetabulum with impaction grafting, there is a large body of evidence from Tom Slooff and his successors that cemented revision with impaction grafting undertaken with strict attention to technical detail is associated with excellent long terms results in all ages and across a number of underlying pathologies including dysplasia and rheumatoid arthritis.

We use revision to a cementless hemispherical porous-coated acetabular cup for most isolated cavitary or segmental defects and for many combined deficiencies. Morsellised allograft is packed in using chips of varied size and a combination of impaction and reverse reaming is used in order to create a hemisphere. There is increasing evidence for the use of synthetic grafts, usually mixed with allograft, in this setting. The reconstruction relies on the ability to achieve biological fixation of the component to the underlying host bone. This requires intimate host bone contact, and rigid implant stability. It is important to achieve host bone contact in a least part of the dome and posterior column – when this is possible, and particularly when there is a good rim fit, we have not found it absolutely necessary to have contact with host bone over 50% of the surface.

Once the decision to attempt a cementless reconstruction is made, hemispherical reamers are used to prepare the acetabular cavity. Sequentially larger reamers are used until there is three-point contact with the ilium, ischium and pubis. Acetabular reaming should be performed in the desired orientation of the final implant, with approximately 200 of anteversion and 400 of abduction (or lateral opening). Removing residual posterior column bone should be avoided. Reaming to bleeding bone is desirable. Morsellised allograft is inserted and packed and/or reverse reamed into any cavitary defects. This method can also be applied to medial wall uncontained defects by placing the graft onto the medial membrane or obturator internus muscle, and gently packing it down before inserting the cementless acetabular component. Either the reamer heads or trial cups can be used to trial prior to choosing and inserting the definitive implant. The fixation is augmented with screws in all cases. Incorporation of the graft may be helped by the use of autologous bone marrow.

Cementless acetabular components with impaction grafting should not be used when the host biology does not allow for stability or for bone ingrowth. This includes the severely osteopenic pelvis, pelvic osteonecrosis after irradiation, tumours, and metabolic bone disorders. They should also not be used in the presence of pelvic discontinuity unless the structure of the pelvic ring has been restored with a plate, or specialised materials/porous metals are used.

The challenge of reconstituting the acetabulum depends on the degree and type of bone loss. The principles of maximising host bone-implant contact and implant stability have borne fruit in our experience with cementless revision. The advantages of bone grafting in acetabular reconstruction include the ability to restore bone stock, to rebuild a normal hip center and hip biomechanics and to increase bone stock for future revisions.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 19 - 19
1 May 2013
Haddad F
Full Access

Periprosthetic fractures in total hip arthroplasty lead to considerable morbidity in terms of loss of component fixation, bone loss and subsequent function. The prevention, early recognition and appropriate management of such fractures are therefore critical. The pathogenesis of periprosthetic factors is multi-factorial. There are a number of intrinsic patient influences such as bone stock, biomechanics and compliance. There are also a host of extrinsic factors over which the surgeon has more control. The prevention of periprosthetic fractures requires careful pre-operative planning and templating, the availability of the necessary expertise and equipment, and knowledge of the potential pitfalls so that these can be avoided both intra-operatively and in follow-up. The key issues here are around identifying the risk, choosing the correct implant, understanding the anatomy, understanding the possible risks and avoiding them and using appropriate technique.

There are a number of recognized risk factors for periprosthetic hip fractures. The prevalence of intra-operative fractures during total hip arthroplasty is higher in the patient with osteopenia/osteoporosis. Other conditions causing increased bone fragility, such as osteomalacia, Paget's disease, osteopetrosis, and osteogenesis imperfecta are also at a higher risk of intra-operative fracture. The use of more and more press fit cementless components has also increased the number of periprosthetic femoral fractures because of the force required to obtain such a fit. Complex deformities of the proximal femur, particularly when associated with a narrow medullary canal, as seen in secondary degenerative joint disease following developmental dysplasia of the hip may also increase the risk of intra-operative fractures. Revision surgery is associated with a higher risk of intra-operative fracture than primary hip replacement surgery. These fractures typically occur during hip dislocation, cement extraction, or reaming through old cement. Other risk factors for post-operative femoral fractures include loosening of the prosthesis with cortical bone loss, local osteolysis, stress risers within the cortex, such as old screw holes, the ends of plates, or impingement of a loose stem against the lateral femoral cortex.

Periprosthetic acetabular fractures are increasingly recognized. This is in part due to the popularity of press fit components, which increase fracture risk both at the time of insertion and later due to medial wall stress shielding and pelvic osteolysis, and partly due to the increasing frequency of severe defects encountered at the time of revision surgery. Both over- and under-reaming are significant risk factors for acetabular fractures during total hip replacement. It is imperative to deal with the osteopenic patient gently and appropriately, being aware of the rim on the acetabular side and having the capacity for screw fixation where needed, having an understanding of where you wish to place your components and creating the appropriate runways for them, thinking about the stability of an implant as it is inserted and understanding that an implant that is less stable than expected probably is associated with either a size mismatch, a fracture or an implant that will not sit properly probably requires more or a different direction of reaming rather than harder blows with a hammer. A typical example where extra care is required is the scenario of a fractured neck of femur that requires total hip arthroplasty. The virgin native acetabulum in a patient likely to have some bony deficiency may be more difficult to deal with as it has a higher fracture risk.

Pre-operative templating helps to identify the correct entry point for preparation of the lateral runway for linear insertion of a femoral stem. If resistance is met during insertion, the situation should be re-appraised to ensure that the direction and level of the rasp and prosthesis are the same. This reduces the risk of varus/valgus positioning which increases the risk of intra- and post-operative fractures. It is also important to avoid a change of version during insertion of the prosthesis as this can lead to high stresses.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 46 - 46
1 May 2013
Haddad F
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Femoroacetabular impingement is defined as abnormal abutment between the femoral head, or the femoral head-neck junction, and the acetabulum. It is now established that FAI is a major etiological factor in the development of osteoarthritis (OA) of the hip.

FAI is increasingly recognized as a cause of hip pain in young active individuals. Clinical features of FAI include pain in the groin but this may also be felt in the gluteal region, trochanteric region, or in the thigh. Symptoms most commonly begin as an intermittent discomfort, often during or following periods of repetitive hip motion e.g. running, walking, progressing to more constant and intense pain. Stiffness is common, with reductions in the range of hip flexion, and internal rotation in particular. Patients may also complain of clicking, popping, or snapping sensations in the affected hip.

Operative treatment of FAI is principally aimed at removing cam lesions and increasing femoral head-neck offset (osteochondroplasty), and treating associated soft tissue lesions such as labral tears. Acetabular recession with labral reattachment is increasingly used for pincers lesions but great care is needed to ensure that the overall coverage of the hip is not reduced. As proficiency with arthroscopic techniques has improved, arthroscopic osteochondroplasty and labral debridement/repair has become increasingly popular for the treatment for FAI, with promising functional results in a range of studies.

150 consecutive patients who underwent hip arthroscopy for CAM type FAI with minimum 1 year follow up were prospectively studied. Patient satisfaction, non-arthritic hip score, re-operations and conversion to arthroplasty were analysed.

There were a total of 90 males and 60 females. The average age group was 32 years (27 to 46 years). All patients underwent osteoplasty of the CAM lesion and stabilisation/ repair of the labral tears. A comparison of pre procedure non arthritic hip scores with the scores at latest follow up (minimum 1 year, maximum 3 years) showed a significant improvement (56 vs 86; p <0.01). There were 2 re operations for unresolved symptoms and 1 conversion to arthroplasty for continued pain associated with significant loss of articular cartilage. Perineal numbness was noted in 9 patients all of which resolved. No other major complications were noted in this series. Hip impingement symptoms resolved in all cases and a good (20 %) to excellent (75%) outcome was reported.

Arthroscopic management of CAM type FAI is associated with subjective and objective improvement in hip function at early follow up. Longer follow-up is necessary to analyse the ability of this procedure to arrest progression of degenerative hip disease.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 67 - 67
1 Mar 2013
Alazzawi S Haddad F
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Introduction

Acute infection following Total Hip Arthroplasty (THA) is a serious complication. It is commonly treated by irrigation and debridement (I&D) with component retention (exchange only the mobile parts of the joint - head and liner). However, the reported re-infection rate with the use of this approach remains high. We are reporting our experience in using single - stage revision arthroplasty in treating acute infection of THA. We hypothesized that the infection control rate after immediate early revision for acute infection of cementless implants is better than has been reported for I&D with exchange of mobile parts.

Methods

From our infection arthroplasty database, we reviewed the outcome of 19 patients who had an acute infection (within 6 weeks) of cementless THA. Our management strategy includes I&D and single-stage (direct-exchange) revision arthroplasty followed by 6 weeks course of culture specific oral antibiotics.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 68 - 68
1 Mar 2013
Jassim S Marson N Benjamin-Laing H Douglas S Haddad F
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Introduction

Technology in Orthopaedic surgery has become more widespread in the past 20 years, with emerging evidence of its benefits in arthroplasty. Although patients are aware of benefits of conventional joint replacement, little is known on patients' knowledge of the prevalence, benefits or drawbacks of surgery involving navigation or robotic systems.

Materials & Methods

In an outpatient arthroplasty clinic, 100 consecutive patients were approached and given questionnaires to assess their knowledge of Navigation and Robotics in Orthopaedic surgery. Participation in the survey was voluntary.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 258 - 258
1 Mar 2013
Matthews D Haddad F
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Arthroplasty performed for the partial or complete resurfacing, remodelling or replacement of a degenerative or dysfunctional joint is a common procedure. The number of total knee and hip arthroplasty procedures performed per year are increasing with the number of total knee arthroplasties (TKA) predicted to more than double by 2030. Although this provides dramatic relief from pain, these implants do have a limited lifespan.

Approximately 10% of total hip arthroplasty (THA) implants require revision due to periprosthetic osteolysis. Approximately 40% require revision due to aseptic loosening believed to be due to polyethylene wear. Arthroplasty prostheses may also fail due to deep infection, malpositioned or oversized implants and peri-prosthetic fractures. It is difficult to predict which patients will develop complications. Therefore follow up has typically involved serial clinical and radiographic assessments for the lifetime of the patient. Despite many collective years of experience there is still disparity in the follow-up of such patients. Elective arthroplasty forms the major bulk of workload in trauma and orthopaedic surgery. Efficient service provision and planning requires an agreed, evidence-based protocol. Currently no consensus exists, however there are many papers detailing the effectiveness of imaging techniques as well as the need for timed clinical assessments.

The authors review current literature regarding hip and knee arthropalsty procedures, potential causes of failure and methods of detection in order to highlight areas of potential future research to enable an evidence-based protocol to be derived.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 186 - 186
1 Mar 2013
Jassim S Patel S Wardle N Tahmassebi J Middleton R Shardlow D Stephen A Hutchinson J Haddad F
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Introduction

In Total Hip Arthroplasty (THA), polyethylene wear reduction is key to implant longevity. Oxidized Zirconium (OxZi) unites properties of a ceramic bearing surface and metal head, producing less wear in comparison to standard Cobalt-Chromium (CoCr) when articulating with Cross-linked polyethylene (XLPE) in vitro. This study investigates in vivo polyethylene (PE) wear, outcomes and complications for these two bearing couples in patients at 5 year follow-up

Methods

400 patients undergoing THA across four institutions were prospectively randomised into three groups. Group I received a cobalt-chrome (CoCr) femoral head/ cross-linked polyethylene (XLPE) liner; Group II received an OxZi femoral head/ ultrahigh molecular weight polyethylene (UHMWPE) liner; Group III received an OxZi femoral head/XLPE liner. All bearing heads were 32 mm. Linear wear rate was calculated with Martell computer software. Functional outcome and complications were recorded.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 13 - 13
1 Mar 2013
Benjamin-Laing H Tahmassebi J Haddad F
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Introduction

The purpose of this study was to evaluate the functional outcome in the medium and long-term of hip resurfacing in comparison with cementless hip replacement in patients under the age of 55.

Methods

Eighty patients were enrolled between 1999 and 2002. Twenty-four were randomised (11 hip re-surfacing, 13 total hip replacement), 18 refused hip resurfacing and chose cementless total hip replacement with a 32 mm bearing, 38 insisted on re-surfacing. All the patients have been reviewed at a minimum follow-up of 8 years and a mean of 10.1 years. Patients were assessed clinically and radiographically at one year, five years, eight years and ten years. Outcome measures included EQ 5, SF 36, Oxford, Harris hip, UCLA and UCH scores.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 202 - 202
1 Jan 2013
Jassim S Marson N Benjamin-Laing H Douglas S Haddad F
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Introduction

Technology in Orthopaedic surgery has become more widespread in the past 20 years, with emerging evidence of its benefits in arthroplasty. Although patients are aware of benefits of conventional joint replacement, little is known on patients' knowledge of the prevalence, benefits or drawbacks of surgery involving navigation or robotic systems.

Materials and methods

In an outpatient arthroplasty clinic, 100 consecutive patients were approached and given questionnaires to assess their knowledge of Navigation and Robotics in Orthopaedic surgery. Participation in the survey was voluntary.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 218 - 218
1 Jan 2013
Benjamin-Laing H Jassim S Liekens K Haddad F
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Background

Adductor muscle and tendon injuries are commonly seen in sport. Complete adductor avulsions have been described and can be managed non-operatively or operatively. A rare variant of this injury is the complete avulsion of the adductor complex with the pectineus and rectus abdominus amounting to a complete sleeve avulsion from the pubis. This is a severe injury that is increasingly recognised due to improved imaging and lower diagnostic threshold.

Purpose

We describe the surgical management of twelve athletes with this severe injury.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 554 - 554
1 Sep 2012
Sukeik M Ashby E Sturch P Aboelmagd K Wilson A Haddad F
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Introduction

Wound surveillance has been reported to result in a significant fall in the incidence of wound sepsis in total knee arthroplasty (TKA). However, there is currently little guidance on the definition of surgical wound infection that is best to be used for surveillance. The purpose of this study was to assess the agreement between three common definitions of surgical wound infection as a performance indicator in TKA; (a) the CDC 1992 definition, (b) the NINSS modification of the CDC definition and (c) the ASEPSIS scoring method applied to the same series of surgical wounds.

Methods

A prospective study of 500 surgical wounds in patients who underwent knee arthroplasties between May 2002 and December 2004 from a single tertiary centre were assessed according to the different definitions of surgical wound infection.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 136 - 136
1 Sep 2012
El-Husseiny M Pendegrass C Elnikety S Haddad F Blunn G
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Introduction

Following amputation, residual stumps used to attach the external prostheses can be associated with sores, infection and skin necrosis. These problems could be overcome by off loading the soft tissues. Intraosseous transcutaneous amputation prostheses (ITAP) attach external implants directly to residual bone reducing these complications. However, a tight seal at the skin implant interface is crucial in preventing epithelial down-growth and infection. Fibronectin (Fn) and laminin 332 (Ln), enhance early cell growth and adhesion of keratinocytes. Silanization to titanium alloy (Ti) allows these proteins to bond to the metal directly. We hypothesize that silanized dual coatings of fibronectin and laminin (SiFnLn) will be more durable than absorbed proteins and that keratinocyte adhesion will be increased compared with Ti controls and single silanized proteins.

Methods

10 mm diameter Ti alloy discs were polished, sterilized and silanized. The kinetics of silanized single and dual protein coating attachment onto titanium alloy was quantified using radio-labelled Fn(125I-Fn) and Ln(125I-Ln). Coating durability was assessed when soaked in fetal calf serum (FCS) for 0, 1, 24, 48, 72hrs. Data was compared to un-silanized Ti discs with the same amount of adsorbed proteins. In order to study cell attachment 20 × 103 keratinocytes were seeded on the discs (n = 6): silanized (Si), silanized fibronectin (SiFn), silanized laminin (SiLn), silanized dual coating (SiFnLn) for 1, 4 and 24hrs. Adhesion of cells was assessed using mouse vinculin antibody for 2hrs and alexafluor for 1hr which stains focal adhesions responsible for attaching cells to surfaces. Axiovision Image Analysis software was used to measure cell area, vinculin markers per cell unit and per unit cell area on 15 cells per disc. Data was analysed in SPSS and significance was assumed at the 0.05 level.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 135 - 135
1 Sep 2012
El-Husseiny M Pendegrass C Haddad F Blunn G
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Introduction

Intraosseous transcutaneous amputation prostheses (ITAP) provide an alternative means of attaching artificial limbs for amputees. Conventional stump-socket devices are associated with soft tissue complications including; pressure sores and tissue necrosis. ITAP resolves these problems by attaching the exo-prosthesis transcutaneously to the skeleton. The aim of this study is to increase the attachment of dermal fibroblasts to titanium alloy in vitro. Fibronectin (Fn) and laminin 332 (Ln) enhance early cell growth and adhesion. We hypothesize that silanized dual coatings of fibronectin and laminin (SiFnLn) will be more durable when compared with adsorbed dual coating (AdFnLn), and will enhance early fibroblast growth and adhesion compared to single coatings.

Methods

The kinetics of dual single and dual protein coating attachment onto titanium alloy was quantified on silanized 10mm diameter discs using radiolabelled Fn (125I-Fn) and Ln (125I-Ln). Sixty discs were polished, sterilized and silanized. Coating durability was assessed when soaked in fetal calf serum (FCS) for 0, 1, 24, 48 and 72hrs. Data was compared to un-silanized Ti discs with the same coatings. Five thousand human dermal fibroblasts were seeded on discs (n = 6) of Ti polished alone (Pol), Ti with adsorbed fibronectin (AdFn), Ti with adsorbed laminin (AdLn), Ti adsorbed dual coating (AdFnLn), Ti silanized (Si), Ti silanized with fibronectin (SiFn), Ti silanized with laminin (SiLn), Ti silanized with a dual coating (SiFnLn) for 24hrs. In order to measure cell adhesion fibroblasts were fixed, vinculin stained using mouse vinculin antibody and alexa fluor. Axiovision Image Analysis software was used to measure cell area, vinculin focal adhesion markers per cell and per unit cell area. Data was analysed in SPSS and significance was assumed at the 0.05 level.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 230 - 230
1 Sep 2012
Vanhegan I Malik A Jayakumar P Islam SU Haddad F
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Introduction

The number of revision hip arthroplasty procedures is rising annually with 7852 such operations performed in the UK in 2010. These are expensive procedures due to pre-operative investigation, surgical implants and instrumentation, protracted hospital stay, and pharmacological costs. There is a paucity of robust literature on the costs associated with the common indications for this surgery.

Objective

We aim to quantify the cost of revision hip arthroplasty by indication and identify any short-fall in relation to the national tariff.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 188 - 188
1 Sep 2012
Hossain F Rambani R Ribee H Koch L Haddad F
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Introduction

Premature cessation of clopidogrel in certain patients with cardiac conditions is associated with an increased risk of recurrent coronary events. Such patients often present with proximal femoral fractures requiring surgical intervention. Our aim was to ascertain whether it is necessary to stop clopidogrel preoperatively to avoid postoperative complications following hip hemiarthroplasty surgery.

Methods

A retrospective review of 102 patients with ongoing clopidogrel therapy and patients not on clopidogrel who underwent hip hemiarthroplasty for an intracapsular proximal femoral fracture was undertaken. Statistical comparison on pre- and postoperative haemoglobin (Hb), ASA grades, comorbidities, operative times, transfusion requirements, hospital length of stay (LOS), wound infection, haematoma and reoperation rates between the two groups was undertaken.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 439 - 439
1 Sep 2012
El-Husseiny M Patel S Hossain F Haddad F
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AIM

Failure of a primary anterior cruciate ligament (ACL) reconstruction is associated with poor functional outcomes even after revision surgery. The aim of this study is to identify early predictors for failure, so that it may aid in recognition of at-risk patients.

METHOD

An observational study was conducted of 623 patients undergoing primary ACL reconstruction by a single surgeon over a 72 month period. Patient and procedure related parameters including age, gender, BMI, time to surgery, graft size, fixation methods, meniscal and chondral injuries, meniscal surgery, radiological parameters and post-operative IKDC scores. Logistic regression modeling was employed to identify those factors which were statistically significant for failure.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 58 - 58
1 Mar 2012
Ashby E Davies M Wilson A Haddad F
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There is mixed evidence in the literature regarding increasing age, ASA and BMI as risk factors for surgical site infection in orthopaedic surgery. To investigate the matter further, we examined 1055 wounds in 1008 patients in the Department of Trauma and Orthopaedic Surgery at University College London Hospital between 2000 and 2006. All patients with a minimum two-night stay were included. Data was collected by four designated research nurses. The age, height, weight and ASA status of each patient was recorded. All wounds were classified using ASEPSIS. This is a quantitative wound scoring method which is a summation of scores calculated from visual wound characteristics and the clinical consequences of infection.

Our results showed a strong linear association between age and ASEPSIS scores. Single variable regression analysis showed a t value of 3.32 and p value of 0.001. A similar linear association was seen between ASA grading and ASEPSIS scores. Single variable regression analysis showed a t value of 2.75 and p value of 0.006. The association between BMI and ASEPSIS scores was markedly different from that seen with age and ASA. The graph was U-shaped with patients with a BMI of 25-30 having the lowest average ASEPSIS scores. Patients with a lower and a higher BMI had higher average ASEPSIS scores. Single variable regression analysis was not significant since the relationship between BMI and ASEPSIS scores is not linear.

In conclusion, there are clearly defined patient groups who are at increased risk of developing a surgical site infection: older patients, patients with a higher ASA, and patients with both a low and high BMI. These patients should be targeted to reduce overall infection rates. This can be achieved by ensuring adequate antibiotic prophylaxis, having a low threshold to treat suspected infection and arranging regular follow-up.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 34 - 34
1 Mar 2012
Konangamparambath S Haddad F
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Hamstring muscle strain is a common sports related injury. It has been reported in a variety of sports, following acceleration or deceleration while running or jumping. Injury may vary from simple muscle strains to partial or complete rupture of the hamstring origin. Avulsion fracture of the ischial tuberosity has also been described. Simple hamstring muscle strains are treated conservatively. Surgical exploration and repair is currently advocated for partial or complete rupture of the hamstring origin. A few case series exists in literature suggesting the benefits of early intervention.

We report a series of 8 athletes who presented between 2002 and 2006 with complete tear of their hamstring origin. Avulsion of the ischial tuberosity was excluded in these cases. After confirming the diagnosis, early surgical exploration and repair or reattachment was performed. The patients were braced for 8 weeks. This was followed by specialist physiotherapy and a supervised rehabilitation programme over 6 months. All patients were followed up to monitor return to normal activities and sports. The sciatic nerve was scarred to the avulsed tendon in three cases. Neurolysis led to a rapid relief of symptoms. Cases where the hamstring origin had retracted more than 3 cm required a figure 7 incision. There were no major complications including nerve palsies.

An excellent functional outcome was noted by 12 months in all 8 patients. 7 of them returned to their previous level within 6-9 months of injury. One person despite a very good recovery, opted out of sports. No other complications were seen as a result of the surgical procedure. In conclusion, a tear of the origin of hamstring muscles is a significant injury. Early surgical repair and physiotherapy is associated with a good outcome and enables an early return to high level sports.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IX | Pages 90 - 90
1 Mar 2012
Rhee S Hossain F Konan S Ashby E Haddad F
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Aim

The aim of our study was to assess lateral tracking of the patella with differing designs of Total Knee Arthroplasty (TKA) and compare to that of the native patella.

Method

A modified caliper was used to measure the width and position of the patella relative to the femur at different degrees of knee flexion. The relationship of the patella midpoint to that of the femur was subsequently assessed. Group 1 consisted of 25 native knees. Group 2 consisted of 25 patients with antero-posterior stabilised knee implant with a spherical medial condyle and a deep lateralised patellar groove, and Group 3 consisted of 25 patients with a conventional cam-and-post design with a midline patellar groove. The mean follow-up was 28 months.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 87 - 87
1 Feb 2012
Patel R Stygall J Harrington J Newman S Haddad F
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We aimed to measure cerebral microemboli load during total hip [THA] and knee arthroplasty (TKA) using transcranial Doppler ultrasound (TCD) and to investigate whether cerebral embolic load influences neuropsychiatric outcome. The timing of the microemboli was also related to certain surgical activities to determine if a specific relationship exists and the presence of a patent foramen ovale was investigated.

Patients undergoing primary THA and TKA underwent a battery of ten neuropsychiatric tests pre-operatively and at 6 weeks and 6 months post-operatively. Microembolic load was recorded using TCD onto VHS tape for subsequent analysis. Patent foramen ovale detection was performed using bolus intravenous injection of agitated saline followed by valsalva manoeuvre. The timing of specific surgical steps was recorded for each operation and embolic load calculated for that period. All patients were assessed for quality of life and orthopaedic outcome measures.

Results

45 THA patients and 50 TKA patients were studied. Cerebral microembolisation occurred in 35% of all patients (10 THA patients and 19 TKA patients). Mean microembolic load was 2.8 per patient for THA and 3.76 per patient for TKA patients. PFO was detected in 29 patients overall. Insertion of the femoral component and deflation of the tourniquet were associated with a larger microembolic loads. Neuropsychiatric outcome was not affected by the low embolic loads. Quality of life and Orthopaedic outcome at 6 months was good.

Conclusion

Cerebral microembolisation occurs in a significant proportion of patients during total hip and knee arthroplasty. The presence of a patent foramen ovale does not appear to influence the incidence of microembolisation or load. Specific surgical activities are associated with generating greater embolic loads and methods of avoiding these emboli such as venting the femur may minimise complications and optimise outcomes. Neuropsychiatric outcomes do not seem to be affected by microembolisation of the brain during total joint arthroplasty.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 303 - 303
1 Jul 2011
Colaco H Oussedik S Paton B Haddad F
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Aim: To investigate the relationship between patient psychological characteristics, adherence to rehabilitation physiotherapy and outcome at one year following anterior cruciate ligament reconstruction.

Methods: 75 consecutive patients undergoing ACL reconstruction by a single experienced surgeon received a pre-operative psychological assessment comprising of five questionnaires; Athletic Identity Measurement Scale (AIMS), Recovery Locus of Control Scale (RLCS), Self-Motivation Inventory (SMI), Hospital Anxiety and Depression Scale (HADS), and Short Form Social Support Questionnaire (SSQ6). Four functional questionnaires were completed pre-operatively by the patient; Subjective Knee Evaluation Form (IKDC 2000), Tegner Activity Scale (TAS), Lysholm Score (LS), and Lower Extremity Functional Score (LEFS). LEFS is a simple, sensitive subjective assessment tool which is sensitive to change. Final outcome was assessed by repeating the functional questionnaires at 1-year post-operatively following rehabilitation. Rehabilitation adherence was measured using the Sport Injury Rehabilitation Adherence Scale (SIRAS) and physiotherapy appointment attendance.

Results: The data were analysed using regression analysis (n=57). Self motivation score (R2= 0.142), a higher athletic identity (R2= 0.067), good social support (R2=0.170) and an internal locus of control or high self efficacy (R2=0.111) were all found to be positive predictors of final outcome. Poor self motivation and an external locus of control are associated with less successful final outcome.

Discussion and Conclusion: Self motivation and self efficacy are positive predictors of final outcome after ACL reconstruction. These aspects may be reinforced during rehabilitation. Patients with an external locus of control and poor self-motivation can be identified and their pre- and post-operative management may be adapted to achieve optimal outcome.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 304 - 304
1 Jul 2011
Konan S Rayan F Meermans G Witt J Haddad F
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Introduction: In recent years, there has been a significant advancement in our understanding of femoro-acetabular impingement and associated labral and chondral pathology. Surgeons worldwide have demonstrated the successful treatment of these lesions via arthroscopic and open techniques. The aim of this study is to validate a simple and reproducible classification system for acetabular chondral lesions.

Methods: In our classification system, the acetabulum is first divided into 6 zones as described by Ilizalithurri VM et al [Arthroscopy 24(5) 534–539]. The cartilage is then graded as 0 to 4 as follows: Grade 0 – normal articular cartilage lesions; Grade 1 softening or wave sign; Grade 2 – cleavage lesion; Grade 3 – delamination and Grade 4 -exposed bone. The site of the lesion is further typed as A, B or C based on whether the lesion is 1/3 distance from acetabular rim to cotyloid fossa, 1/3 to 2/3 distance from acetabular rim to cotyloid fossa and > 2/3 distance from acetabular rim to cotyloid fossa.

For validating the classification system, six surgeons reviewed 14 hip arthroscopy video clips. All surgeons were provided with written explanation of our classification system. Each surgeon then individually graded the cartilage lesion. A single observer then compared results for observer variability using kappa statistics.

Results: We observed a high inter-observer reliability of the classification system with a kappa coefficient of 0.89 (range 0.78 to 0.91) and high intra-observer reliability with a kappa coefficient of 0.91 (range 0.89 to 0.96).

Discussion: In conclusion we have developed a simple reproducible classification system for acetabular cartilage lesions.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 299 - 299
1 Jul 2011
Konan S Soler A Haddad F
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Introduction: The purpose of this study was to assess the efficacy and complications associated with revision hip arthroplasty undertaken in patients under the age group of 55 years.

Methods: A review of our institutions revision hip database showed that 430 revision hip arthroplasties undertaken over the past 9 years had a minimum follow up of 2 years. Of this 84 (56 female, 38 male) patients were under 55 years of age (range 2 to 8 years). The index procedures were preformed at an average age of 46 years (range 15 years to 54 years). The single major etiology of failure was aseptic loosening (74%), followed by infection (8%) and recurrent dislocation (7%). In majority of cases uncemented implants were used at revision surgery (91% femoral stem, 100% acetabular cups). Bone grafts were necessary in 39% of cases.

Results: There was 1% incidence of DVT requiring treatment and 1% incidence of deep infection requiring a further revision hip surgery. There were no cases of dislocation in this series. At final follow up satisfactory progress was noted in all cases with a significant improvement in Harris hip score (p < 0.05).

Discussion: In conclusion, revision of hip arthroplasty in patients below 55 years is associated with improvement in function and patient satisfaction. They perform better than older cohorts but not as good as primary THRs. The complication profile is comparable in the two groups.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 303 - 304
1 Jul 2011
Konan S Rayan F Haddad F
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Introduction: The radiographic evaluation of the antero-lateral femoral head is an essential tool for the assessment of cam type of femoroacetabular impingement. Computerised tomography (CT), magnetic resonance imaging and frog lateral plain radiograph views have all been suggested as imaging options for this type of lesion. The alpha angle is accepted as a reliable indicator of cam type of impingement and this may also be used as an assessment tool for successful operative correction of the cam lesion. The aim of our study was to analyse the reliability of The frog lateral view plain radiographs to analyse the alpha angle in cam femoroacetabular impingement.

Patients and Methods: Thirty two patients who presented with femoroacetabular impingement were studied. Interobserver reliability for assessment of alpha angles on frog lateral radiographic view was analysed using intraclass correlation coefficient. The alpha angles measured on frog lateral views using digital templating tools were compared to those measured on CT scans.

Results: A high interobserver reliability was noted for the assessment of alpha angles on frog lateral views with a correlation coefficient of 0.83. The average alpha angles measured on frog lateral views was 58.71 degrees (range 32 to 83.3). The average alpha angle measured on CT was 65.11 degrees (range 30 to 102). However, a poor correlation (Spearman r of 0.2) was noted between the measurements using the two systems.

Conclusions: Frog lateral plain radiographs are not reliable predictors of alpha angle. Various factors may be responsible for this such as the projection of the radiographs, patient positioning and quality of images. CT imaging may be necessary for accurate measurement of the alpha angle.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 91 - 91
1 May 2011
Sukeik M Alshryda S Lou T Haddad F
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Background: Total hip replacement (THR) is one of the commonest operations in orthopaedic practice.

Literature review showed that 20–70% of patients who underwent THR needed 1–3 units of blood. Although safer than ever, allogeneic transfusion is still associated with risks for the recipient. There has been unsettled search for ways to reduce such blood loss and transfusion.

Tranexamic acid has been popularised as an effective way to reduce blood loss and subsequent blood transfusion.

Objectives: To investigate the value of Tranexamic acid in reducing blood loss and blood transfusion after THR and other clinical outcomes such as deep venous thrombosis (DVT), pulmonary embolism (PE), ischaemic heart diseases and mortality.

Patients and Methods: A systematic review and meta-analysis of published randomised and quasi-randomised trials which used tranexamic acid to reduce blood loss in hip arthroplasty was conducted. The data was evaluated using the generic evaluation tool designed by the Cochrane Bone, Joint and Muscle Trauma Group.

Results:

Blood loss

Seven studies (250 patients) were eligible for this outcome. Using Tranexamic acid reduced blood loss by an average of 155 ml (P-value < 0.00001, 95% CI (87–224), Heterogeneity I2 69 %.)

Blood transfusion

Nine studies (463 patients) were eligible for this outcome. Tranexamic acid led to a reduction in the proportion of patients requiring blood transfusion (Odds Ratio of 0.35, P- value < 0.00001, 95% CI (0.22–0.55), Heterogeneity I2 25 %.)

Other outcomes

There were no significant differences in the length of stay, DVT, PE, mortality, wound haematoma or infections between the study groups.

Conclusion: The use of Tranexamic acid in THR results in significant reduction of blood loss and blood transfusion.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 89 - 89
1 May 2011
Nawabi D Chin K Keen R Haddad F
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Introduction: The presence of low levels of vitamin D in osteoarthritic patients has been reported as a substantial problem. We are not aware of any previous studies that have assessed the function of osteoarthritic patients undergoing joint replacement who are vitamin D deficient. This may be an important factor infiuencing preoperative function and postoperative outcome. The aim of this study was to investigate whether low vitamin D levels are associated with functional deterioration in patients with osteoarthritis of the hip undergoing total hip arthroplasty.

Methods: We measured plasma 25-hydroxyvitamin D3 (25(OH)D3) levels in 62 consecutive Caucasian patients undergoing total hip arthroplasty for osteoarthritis. The patients were divided into two groups based on whether they were vitamin D sufficient or deficient. The groups were matched for age, gender and ASA grade.

Results: The prevalence of vitamin D deficiency in our cohort of patients was comparable to recent population-based studies performed in the UK. Patients with vitamin D deficiency had lower preoperative Harris hip scores (Mann-Whitney test, p = 0.018) and were significantly less likely to attain an excellent outcome from total hip arthroplasty (Chi-square test, p = 0.038). Vitamin D levels were found to positively correlate with both preoperative and postoperative Harris hip scores.

Discussion: Our results warrant further study of vitamin D deficiency in patients undergoing joint replacement as it is a risk factor for suboptimal outcome which is relatively simple and cheap to correct.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 94 - 95
1 May 2011
Hossain F Knott K Patel S Konan S Rayan F Haddad F
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Introduction: Blood transfusion is not uncommon in patients following joint replacement surgery. However, allogeneic transfusion is associated with potential risks ranging from immune mediated allergic reactions to transmission of blood-borne organisms. Furthermore its use has a significant economical impact on healthcare services.

Methods: A retrospective audit of the case notes and haematological records of 196 patients who underwent primary total hip (THR), resurfacing hip (BHR) or total knee replacement (TKR) was carried out. Patients were routinely cross-matched for 2 units of blood if their pre-operative haemoglobin (Hb) levels were < 12g/dL in our cohort. Patient details including age, sex, BMI, comorbidities, and ASA grade were also collected. Surgical parameters such as operation time, tourniquet time (for TKR procedures) and trigger haemoglobin levels (Hb) with timing of transfusion were noted. Statistical analysis was undertaken to identify risk factors for transfusion.

Results: Forty-seven (24%) patients were transfused in our cohort. 78.7% of these patients were appropriately transfused with a trigger Hb of < 8g/dL. Patients transfused with a trigger Hb of > 8g/dL were no different with respect to demographics, procedure type and comorbidities. The average postoperative time interval to transfusion was 2.1 days. Five patients required an intra-operative transfusion. The mean pre-operative Hb levels in transfused and non transfused patients were 12.4 g/dL and 13.5 g/dL respectively. The mean number of units transfused was 2.31. A total of 109 units of blood were used: of these 70 units were cross-matched pre-operatively.

Univariate analysis established a significant relationship between the need for postoperative transfusion and preoperative Hb levels (p< 0.0001), length of surgery (p=0.01), age (p=0.03), history of respiratory disease (p=0.028) and hypertension (p=0.01). There was no significant relationship with respect to ASA grade and procedure type. Multivariate logistic regression analysis revealed pre-operative Hb (p< 0.0001) and age (p=0.015) as the strongest predictors of the need for post-operative transfusion. There is a strong correlation between length of surgery and time interval to transfusion (p=0.037).

Conclusion: Utilisation rates of blood products after primary hip and knee arthroplasty procedures exceed that of what is available from pre-operative cross-matching. In our institution more than 20% of patients may have been transfused inappropriately based upon local guidelines. The decision to cross-match blood pre-operatively for elective arthroplasty procedures should be re-evaluated in light of both patient age and pre-operative Hb levels. Postoperative monitoring of Hb levels should be undertaken early in patients with a prolonged duration of surgery.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 219 - 219
1 May 2011
Haddad F Barrack R Soler A
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Introduction: Third generation fixation systems allow for the retightening of cables, and are associated with high rates of trochanteric union. This is a prospective study undertaken to evaluate the outcome of the first 40 patients treated with a third generation cable plate and trochanteric hook system.

Methods: 36 patients treated by two revision hip arthroplasty surgeons using a third generation cable plate system were enrolled and followed up. These included 28 females and 12 males with an average age of 64 (range: 48–91). Large hooks were used in 30 with an average of 4.8 cables (range: 4–9). The need to retighten cables intra-operatively was noted. Clinical and radiographic follow-up was undertaken at 2 years.

Results: A third generation fixation system was used for 16 peri-prosthetic fractures, 6 trochanteric non unions, 5 structural femoral allografts, 6 complex revisions and for trochanteric advancement in 3 cases. The first cable tightened was loose by the end of the procedure in the majority of cases and had to be retightened. There were no cases of fretting or cable breakage. Two further tro-chanteric non unions needed re-fixation and bone grafting in a further procedure

Discussion and Conclusion: Third generation cable system allow for re-tightening, as the cable is not damaged by the crimping mechanism. This facility appears critical as some retightening is invariably required in the process of applying this type of device. There were only 2 re-operations for trochanteric non unions, but the overall outcomes were otherwise excellent, with no fretting or cable breakage. Modern cable systems afford improved, more flexible trochanteric fixation possibilities.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 151 - 151
1 May 2011
Sukeik M Dobson M Bridgens A Haddad F
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Introduction: Up to 2% of total knee arthroplasties (TKA) are still complicated by infection. This leads to dissatisfied patients with poor function, and has far-reaching social and economic consequences. The challenge in these cases is the eradication of infection, the restoration of full function and the prevention of recurrence. We report the outcome of prosthesis sparing early aggressive debridement in the acutely infected TKA.

Methods: We studied 29 consecutive patients referred with acutely infected TKA (18 primaries, 11 revisions) which occurred within 6 weeks of the index operation or of haematogenous spread. Microbiology confirmed bacterial colonization in all cases with 20 early postoperative infections and 9 cases of acute haematogenous spread. All patients underwent aggressive open debridement, a thorough synovectomy and a change of insert. Antibiotics were continued until inflammatory markers and the plasma albumin concentration returned to within normal limits.

Results: Three patients required multiple washouts. 8 patients needed a two stage revision. 21 patients returned to their expected functional level without removal of the implants and with no radiographic evidence of prosthetic failure. At a minimum 2 years follow-up, we had a 72% infection control rate. The outcome was significantly better in patients treated in the first 120 hours after presentation.

Discussion and Conclusion: Our data suggests that there is a role for early aggressive open debridement in acute infections after TKA with an excellent chance of prosthesis salvage.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 175 - 175
1 May 2011
Patel S Hossain F El-Husseiny M Haddad F
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Introduction: Rupture of the anterior cruciate ligament (ACL) is a serious injury associated with symptomatic instability of the knee. There is an increasing trend for confirmation of diagnosis with magnetic resonance imaging (MRI) before proceeding to reconstruction. The overall sensitivity and specificity of diagnosis using this modality is more than 95%. It is however observer-dependent. We have developed a simple 4 point recognition card to increase the pick-up rate of this injury for professionals without specific radiological training such as orthopaedic trainees. The aim of this study was to determine how much improvement could be achieved using this card and whether any change was sustained.

Methods: 20 participants (orthopaedic trainees surgeons and medical students) were shown 20 MRI scans of the knee (10 with complete ACL ruptures and 10 with normal ACLs) and asked which scans were demonstrative of ACL pathology. Each participant was then randomly allocated to either having verbal teaching in the standard fashion about detection of ACL injuries [Group 1] or given written cards detailing a 4 point recognition plan for recognising ACL injuries on MRI [Group 2]. A repeat test of MRI scans was performed on each participant immediately after the teaching session and at 3 weeks.

Results: The mean time taken to teach Group A was 14 mins and Group B was 11 mins (p < 0.05). The mean number of correct diagnoses was 2.7/10 in Group A and 3.1/10 in Group B pre-intervention (p > 0.05). Immediately following intervention, there were 6.1 correct diagnoses in Group A and 8.2 in Group B (p < 0.05). At 3 weeks, there were 3.4 correct diagnoses in Group A and 7.9 in Group B (p < 0.05). The difference in number of correct diagnoses at 3 weeks compared to immediately following intervention was significant in Group A (p < 0.05), but not in Group B (p > 0.05).

Conclusions: The results support the use of the 4 point recognition card as to tool for increasing the pick-up of ACL injuries on MRI. It offers advantages over standard teaching Methods: since it takes less time to teach and the necessary information is retained to a greater degree than with traditional teaching methods.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 212 - 212
1 May 2011
Patel S Haddad F Soler JA Tahmassebi J Wardle N Hossain F
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Introduction: The bearing surface of total hip arthroplasty (THA) is a key factor in implant survivorship. Ceramic bearings have enhanced wear properties though are prone to fracture and thus Oxinium has been developed as an alternative. The aim of our study was to compare the its wear properties against cobalt-chrome which is currently the most widely used femoral head bearing surface in THA.

Methods: We prospectively randomized 270 consecutive patients undergoing THA at one institution into three groups: Groups I, II and III. Group I received a cobalt-chrome femoral head and cross-linked poly-ethylene (XLPE) liner; Group II received an oxinium femoral head and ultrahigh molecular weight polyeth-ylene (UHMWPE) liner; Group III received an oxinium femoral head and cross-linked polyethylene liner. 32 mm heads were used in all the cases. Patients were longitidunally followed up with clinical evaluation and standardised radiographs of the pelvis and hip. Using DICOMeasure software, we calculated the linear and volumetric wear rate for each group to determine if a difference existed.

Results: The demographics and comorbid conditions were similar between the groups. The survivorship of all components was 100% in all groups at 2 years. No patients were lost to follow-up. After the first 6 months of creep, the rate of linear wear over 2 years was 0.16mm for Group I, 0.10mm for Group II, and 0.06mm for Group III. ANOVA testing demonstrates statistical significance between the groups (P < 0.05).

Discussion and Conclusion: Our results demonstrate that the wear rate using 32mm Oxinium heads is significantly lower than that for cobalt-chrome heads and this effect is dramatically enhanced when used in combination with highly cross linked polyethylene.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 4 | Pages 568 - 568
1 Apr 2011
Haddad F


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 18 - 18
1 Jan 2011
Konan S Kalia P Oussedik S Dodd M Coathup M Haddad F Blunn G
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We investigated the hypothesis that autologous bone marrow stromal cells (BMSC) sprayed on the surface of acetabular cups would improve bone formation and bone implant contact.

Total hip replacements were implanted in 11 sheep, randomly assigned to receive either acetabular implants sprayed with autologous BMSCs suspended in fibrin (study group) or fibrin only (control group). Sheep were sacrificed after six months and the acetabulum with the implant was retrieved and prepared for undcalcified histology. Implant bone contact in both groups was compared, by microscopically noting the presence or absence of new bone or fibrous tissue along the implant at 35 consecutive points (every 1000 μm). The observers undertaking the histological analysis were blinded.

Significantly increased bone implant contact was noted in the BMSC treated group 30.71% ± 2.95 compared to the control group 5.14% ± 1.67 (p = 0.014). The mean thickness of fibrous tissue in contact with the implant was greater at the periphery 887.21mm ± 158.89 and the dome 902.45mm ± 80.67 of the implant in the control group compared to the BMSC treated group (327.49mm ± 20.38 at the periphery and 739.1 mm ±173.72 at the centre). Conversely direct bone contact with the implant surface was significantly greater around the cups with stem cells.

BMSC sprayed on surface of implants improves bone implant contact. Spraying acetabular cups using stem cells could be used in humans where acetabular bone contact is compromised such as in revision procedures.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 42 - 42
1 Jan 2011
Konan S Bull J Haddad F
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Our aim was to ascertain the opinion of Orthopaedic Consultants, General Practitioners, and Patients on the proposed primary care based follow up of joint replacements.

An email questionnaire was sent Orthopaedic Consultants registered with the BOA. Responders had to answer simple questions regarding follow up practices after hip and knee arthroplasty and safe alternatives to the existing system. General practitioners in London were sent a different questionnaire to assess their familiarity with follow up of arthroplasty patients and their competence in identifying complications. Finally, arthroplasty patients were directly questioned on their preference for follow up.

Eigthy-one Orthopaedic Consultants who undertake lower limb arthroplasty responded, 89.06% advocated follow up and review of radiographs by the surgeon. The Arthroplasty Practitioner, the Radiologist and the Physiotherapist were deemed suitable for follow up of patients by 50%, 14.06% and 4.69 % respectively. All responders unanimously disagreed with initial follow up by General Practitioners (0%). However, after a 12 month review, 30.15% thought primary arthroplasty patients could be discharged to the care of their General Practitioner and 11.11% were happy to discharge revision arthroplasty patients. Of the 52 General Practitioners who returned our questionnaire, only 37% were confident of interpreting symptoms related to prosthetic loosening or infection and 98% did not feel competent identifying radiological changes after arthroplasty. 94% of the General Practitioners did not think that they would be happy to follow up arthroplasty patients even if they were offered further training. The reasons for this were lack of specialty skills, work-load concerns, funding issues and surgeons’ duty of care towards the patient. All of the 104 patients who were questioned preferred to be followed up by the arthroplasty team.

In conclusion, Orthopaedic Surgeons, General Practitioners and patients prefer a hospital based dedicated Orthopaedic team for the post operative follow-up of arthroplasty patients.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 525 - 525
1 Oct 2010
Meermans G Haddad F Witt J
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Background: Cam-type femoroacetabular impingement (FAI) is becoming more recognized. Cartilage lesions of the acetabulum and labral tears are frequently encountered. The goal of this study was to accurately describe and communicate these injuries and thus providing a standard for reporting injury, management, and outcome.

Methods: We evaluated acetabular cartilage lesions and labral tears found during hip arthroscopy in 52 patients with radiological signs of cam-type FAI. They were graded according to the morphology and extent of the lesion. The labral tears were described according to the classification by Lage.

Results: Eleven patients (21.2%) had normal cartilage, 14 (26.9%) had a grade 1, 17 (32.7%) a grade 2, 6 (11.5%) a grade 3, and 4 (7.7%) a grade 4 lesion. Labral tears were found in 31 patients (59.6%). There was a high correlation between age and the presence and extent of acetabular cartilage and labral lesions (r=0.70; p< 0.0001 and r=0.45; p< 0.001 respectively). There was also a high correlation between the extent of the acetabular cartilage lesion and the presence of labral lesions (r=0.62; p< 0.0001).

Conclusion: In our study there was a high prevalence of associated injuries (86.5%) in cam-type FAI. Despite the recognized consequences of associated lesions on treatment and outcome, no classification system includes this aspect of FAI. Based on our findings, we developed a system to grade acetabular cartilage lesions according to their morphology and extent. This should provide the surgeon with a standardized tool to better describe the full extent of the injury and treat it accordingly.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 505 - 505
1 Oct 2010
Konan S Haddad F Rhee S Tamini N Zhang T
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Radiographs are frequently ordered following acute knee injury. However, it is suggested that only 6 % of patients with a knee trauma have a fracture. Decision rules such as the Ottawa rules and the Pittsburgh rules have been developed to reduce the unnecessary use of radiographs following knee injury.

We prospectively reviewed all acute knee injury patients who were referred to our clinic from the emergency department over a 3 month period. The reason for ordering radiographs was analysed. The Ottawa and the Pittsburgh rules were applied to individual patients to evaluate the need for radiographs. In patients with a diagnosis of fracture, the accuracy of the Ottawa and the Pittsburgh rules was studied.

A total, of 106 patients were referred to the acute knee clinic from the emergency department. 95.28 % (101) of these patients had radiographs of their knee in the emergency department. Five (4.72%) patients had a fracture of their knee and all these cases, the Ottawa and the Pittsburgh knee rules for ordering radiographs was fulfilled. In a vast majority of cases without any fracture, the clinical reason for ordering radiographs was not clear. Using the Ottawa rules for knee radiography 25.47% (27) radiographs could be avoided without missing a fracture. Using the Pittsburgh rules, 30.19 % (32) knee radiographs could be avoided without missing a fracture.

The Ottawa and the Pittsburgh rules have a high sensitivity for the detection of knee fractures. Use of these rules can aid efficient clinical evaluation of the knee in an emergency situation without adverse clinical outcome. They may also have an implication on reducing the work load of radiology department and reduction of health costs.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 522 - 522
1 Oct 2010
Konan S Haddad F Rayan F
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Radiographic evaluation of the anterolateral femoral head is an essential tool for the assessment of cam type of femoroacetabular impingement. Computerised tomography (CT), magnetic resonance imaging and frog lateral plain radiograph views have all been suggested as imaging options for this type of lesion. Alpha angle is accepted as a reliable indicator of cam type of impingement and this may also be used as an assessment tool for successful operative correction of the cam lesion.

The aim of our study was to analyse the reliability of frog lateral view plain radiographs to analyse the alpha angle in cam femoroacetabular impingement.

Thirty two patients who presented with femoroac-etabular impingement were studied. Interobserver reliability for assessment of alpha angles on frog lateral radiographic view was analysed using intraclass correlation coefficient. The alpha angles measured on frog lateral views using digital templating tools were compared to those measured on CT scans.

A high interobserver reliability was noted for the assessment of alpha angles on frog lateral views with a correlation coefficient of 0.83. The average alpha angles measured on frog lateral views was 58.71 degrees (range 32 to 83.3). The average alpha angle measured on CT was 65.11 degrees (range 30 to 102). However, a poor correlation (Spearman r of 0.2) was noted between the measurements using the two systems.

Frog lateral plain radiographs are not reliable predictors of alpha angle. Various factors may be responsible for this such as the projection of the radiographs, patient positioning and quality of images. CT imaging may be necessary for accurate prediction of alpha angle.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 503 - 503
1 Oct 2010
El-Husseiny M Haddad F Potty A Rayan F
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Background: Medial plica syndrome is the most common symptomatic plica. The size and shape of the plica have an important impact on impingement on the femoral condyle and hence, symptoms. The validity of the classification systems of such injuries is essential for prospective studies. The study was designed to assess the reproducibility and reliability of Iino and Jee classification systems of medial plica syndrome. The agreement among multiple surgeons for medial plica syndrome has not been established before.

Methods: We validated both classification systems independently from the original authors at our institution. Arthroscopic videos from 30 patients were reviewed by 6 consultant surgeons, 6 registrars and 6 house officers. Intra- and inter-observer reliability and reproducibility were assessed. Each observer scored the videos on two separate occasions and classified the medial plica according to its type (A, B, C and D) for Iino classification and (1, 2, 3 and 4) for Jee classification system.

Results: The results were subjected to weighted kappa analysis. Intra-observer agreements were 0.76 for consultants, 0.64 for registrars and 0.60 for house officers for Iino classification system. They were 0.81 for consultants, 0.75 for registrars and 0.71 for house officers for Jee classification system. Total unanimity (18 observers assigned same grade for medial plica) was achieved in 23% (7 of 30) with Iino system and 40%(12 of 30) for Jee system. Inter-observer agreement was 0.63 for the first reading and 0.68 for the second reading for Iino system. They were 0.72 for the first reading and 0.80 for the second reading for Jee system. Validity analysis showed a kappa value of 0.78 (substantial agreement).

Conclusions: Jee classification system showed a better inter and intra-observer agreement compared to Iino’s system. Consultants had a better intra-observer agreement compared to their registrars. We have shown that substantial agreement can be found between individuals with no specialist training. Such reliability is crucial for multi-centre clinical research studies involving arthroscopic knee surgery. Jee’s classification system did not consider femoral condyle impingment which has an important effect on symptoms. Both systems should be used in prospective studies to evaluate the state of the medial plica.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 522 - 522
1 Oct 2010
Konan S Guerts J Haddad F Meermans G Rayan F
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The aim of our study was to determine the usefulness of preoperative digital templating of cementless total hip arthroplasty (THA).

60 consecutive cementless THA (synergy stem & reflection cup) were templated digitally by two senior hip arthroplasty fellows (GM, YG) independently. A metallic marker ball of known diameter was used in all images to help scale for magnification. A blinded observer then collated information on the actual implant sizes, size of head component, offset, and level of neck cut intraoperatively. This was used to statistically analyse the correlation (Interclass correlation coefficient) between the digitally templated implant sizes and actual implant sizes used and the reliability of digital templating.

A high rate of coincidence between digitally templated estimates and actual implant sizes was noted for both groups of templates. A high intraclass correlation coefficient (ICC) for the acetabular cup, stem and head were noted (ICC of 0.825, 0.794, and 0.884 respectively). Moderate agreement was noted for neck cut (ICC of 0.567) and leg length (ICC of 0.612).

In conclusion, digital templating can reliably estimate implant sizes in cementless total hip arthroplasty. Valuable information on neck cut and leg length can be obtained by preoperative templating.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 400 - 400
1 Jul 2010
Konan S Haddad F
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We describe our novel approach to managing infected periprosthetic fractures using a revision implant for temporary fracture stabilisation.

A series of 12 consecutive patients aged between 74 and 83 years (average age 81.51, SD 6.32) who were referred to the senior author with periprosthetic fracture and microbiologically proven infection, were managed by radical debridement and antibiotic therapy along with temporary implantion of a long stem cannulated, proximally hydroxyappatite coated and distally locked femoral prosthesis (Cannulock, Orthodesign, Christ-church, UK). Strut grafts, demineralised bone matrix and cable plating system where used in addition where indicated. Post operatively patients were allowed to mobilise as allows and antibiotics were continued until biochemical markers returned to normal.

A good clinical outcome and excellent functional outcome was noted in all 12 cases. No cases of immediate post operative complications such as DVT or PE were noted in any cases. In particular there were no instances of infections associated with prolonged immobilisation and hospital stay. Ten patients underwent a definitive revision hip replacement procedure within an average of 4.3 weeks (range 3.9 to 5.7, SD 2.15). Two patients required a second debridement and delayed definitive treatment due to persistently high inflammatory markers.

We believe that this novel approach significantly improves functional outcome in the management of infected periprosthetic fractures.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 414 - 414
1 Jul 2010
Colaço H Oussedik S Paton B Haddad F
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Introduction: The aim of this study is to investigate the relationship between patient psychological characteristics, adherence to rehabilitation physiotherapy and outcome at one year following anterior cruciate ligament reconstruction.

Methods: A group of 57 patients undergoing ACL reconstruction received a pre-operative psychological assessment comprising of five questionnaires; Athletic Identity Measurement Scale (AIMS), Recovery Locus of Control Scale (RLCS), Self-Motivation Inventory (SMI), Hospital Anxiety and Depression Scale (HADS), and Short Form Social Support Questionnaire (SSQ6). Four functional questionnaires were completed pre-operatively by the patient; Subjective Knee Evaluation Form (IKDC 2000), Tegner Activity Scale (TAS), Lysholm Score (LS), and Lower Extremity Functional Score (LEFS). Final outcome was assessed by repeating the functional questionnaires at 1-year post-operatively following rehabilitation. Anterior displacement of the tibia was recorded using a KT1000 arthrometer pre-operatively and at 1 year postoperatively. Adherence to rehabilitation was recorded using the Sport Injury Rehabilitation Adherence Scale (SIRAS) and attendance to physiotherapy appointments.

Results: The data were analysed using regression analysis. Self motivation, a higher athletic identity, good social support and an internal locus of control are all positive predictors of final outcome. Poor self motivation and an external locus of control are associated with less successful final outcome. Rehabilitation adherence is also a positive predictor of final outcome, although psychological factors were not found to be predictive of adherence to rehabilitation.

Discussion and Conclusion: Self motivation and an internal locus of control are positive predictors of adherence to physiotherapy and final outcome. These aspects can be reinforced during rehabilitation. Patients with an external locus of control and poor self-motivation can be identified and their pre- and post-operative management adapted to achieve optimal outcome.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 309 - 309
1 May 2010
Rhee S Konangamparambath S Haddad F
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Aim: The purpose of this study is to explore the experience of a consultant orthopaedic surgeon, and to quantitatively describe the learning curve for hip arthroscopy.

Introduction: Arthroscopic surgery in orthopaedics is a well established procedure for both diagnostic and therapeutic purposes. Unlike many other joint arthroscopies, hip arthroscopy has been delayed in its development. It was first pioneered by Burman in 1931, who under-took a study on cadavers, stating that ‘it is manifestly impossible to insert a needle between the head of the femur and the acetabulum’. Over several decades, this technique has developed considerably, but still remains a technically demanding and difficult procedure. The learning curve for hip arthroscopy has not previously been objectively quantified.

Method: We prospectively reviewed the first 100 hip arthroscopies performed in the supine position between 1999 and 2004. Surgery was performed by a single experienced hip and knee consultant orthopaedic surgeon (FH). We assessed the operative time (traction time), surgeon comfort, patient satisfaction at 6 months and operative complications. This was analysed for consecutive blocks of 10 cases. Results of the first 10 and the remaining 90 cases, subsequently the first 20 and remaining 80 cases, and finally the first 30 and remaining 70 cases were compared for a difference.

Results: The mean traction time was 55 minutes (range: 36–94 minutes). Mean surgeon comfort was 73% (range: 52–89%). 49% of patients reported an excellent outcome at 6 months follow – up. Only 8% of patients reported an unsatisfactory outcome. The main complications noted were chondral damage (6 cases) and perineal injuries (4 cases). There was a remarkable decrease in complications from the first 30 cases compared to the remaining 70 operations. 5 cases of chondral damage was noted in the first 30 cases, compared to 1 (1.4%) in the remaining 70 cases. The number of perineal injuries was noted to decrease from 3 cases in the first 30 operations to 1 (1.4%) in the subsequent 70 operations.

There is an overall decrease in operative time over the 100 cases, representing a gradual learning process throughout. However, the fall from an average time of 75 minutes for the first 30 cases, to the average operative time of 30 minutes for the remaining 70 cases, is a significant learning process (40% fall in operative time). We thus, believe the learning curve to be 30 operations.

Conclusion: We have demonstrated that there is a considerable fall in operative time when comparing the first 30 cases with the remaining 70 cases. This quantitative decrease is indicative of a rapid learning curve. This is further suggested by the remarkable fall in complications during this learning phase.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 303 - 303
1 May 2010
Konan S Kalia P Oussedik S Coauthup M Dodd M Haddad F Blunn G
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Despite advances in total hip arthroplasty, failure of acetabular cup remains a concern. The role of bone marrow stromal cells (BMSCs) to aid osseointegration of orthopaedic implants have been recently studied. We investigated the hypothesis that autologous BMSCs sprayed on the surface of acetabular cups would improve bone formation and bone implant contact.

Total hip replacements were implanted in 11 sheep, randomly assigned to receive either acetabular implants sprayed with autologous BMSCs suspended in fibrin (study group) or fibrin only (control group). Sheep were sacrificed after six months and the acetabulum with the implant was retrieved and prepared for undecalcified histology. Implant bone contact in both groups was compared microscopically, by noting the presence or absence of new bone or fibrous tissue along the implant at 35 consecutive points (every 1000 μm). The observers undertaking the histological analysis were blinded.

Significantly increased bone implant contact was noted in the BMSC treated group 30.71% ± 2.95 compared to the control group 5.14% ± 1.67 (p = 0.014). The mean thickness of fibrous tissue in contact with the implant was greater at the periphery 887.21mm ± 158.89 and the dome 902.45mm ± 80.67 of the implant in the control group compared to the BMSC treated group (327.49mm ± 20.38 at the periphery and 739.1 mm ± 173.72 at the centre). Conversely, direct bone contact with the implant surface was significantly greater around the cups with BMSCs.

Our data demonstrate that BMSC sprayed on surface of acetabular implants improves bone implant contact. Spraying acetabular cups using stem cells could be used in humans where acetabular bone contact is compromised such as in revision procedures.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 124 - 125
1 Mar 2010
Rhee S Ashby E Wilford P Tuke M Haddad F
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Studies have shown that the normal patella tracks laterally with flexion of the knee joint, consistent with the findings of Eckhoff et al. that the femoral sulcus is lateral to the mid-plane between the 2 femoral condyles. Patellar pain and instability is a known complication of Total Knee Arthroplasty (TKA). To date, several studies have identified the effect of femoral and tibial components on complication after TKA. However, there is very little work on how the design of the implant affects patellar tracking. Our study compares lateralization of the patella in two different AP stabilized knee implants.

A modified caliper was used to measure the width and position of the patella relative to the femur at different degrees of knee flexion. The relationship of the patella midpoint to that of the femur was subsequently assessed. Group 1 consisted of 25 native knees. Group 2 consisted of 25 patients with antero-posterior stabilized knee implant with a spherical medial condyle and a deep lateralized patellar groove (MRK, Finsbury Orthopaedics, UK). And Group 3 consisted of 25 patients with traditional cam-and-post posterior cruciate-substituting implant with a symmetrical patellar groove (PFC-Sigma, DePuy, UK). The mean follow-up for the 50 TKAs was 28 months.

Lateral tracking corresponded well in all groups, but the mean lateral displacement of the patella in group 2 correlated more closely to that of group 1. At 90 degrees of flexion, the patella was displaced a mean of 7mm laterally in both groups 1 and 2, but a mean of 4mm in group 3. Two-tailed Mann-Whitney U test (95% confidence interval) showed that the difference in lateral patellar displacement between groups 1 and 3, and that between groups 2 and 3 were statistically significant (p< 0.05). However, the patellar displacement between groups 1 and 2 was not statistically different.

Our results indicate that lateral patellar displacement in group 2 is similar to that of native knees (group 1). The effect of the underlying lateralized deep patellar groove of the femoral component in group 2 is more able to mimic that of the native femoral sulcus. This intrinsic implant design accommodates the natural tracking of the patella.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 419 - 419
1 Sep 2009
Konan S Haddad F
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Purpose of study: The aim of this study was to look at the clinical outcome of PLC interference screws in knee ligament reconstruction surgery.

Materials & Results: We prospectively followed up 60 patients who underwent primary anterior cruciate ligament (ACL) reconstructions using PLC (Calaxo; Smith & Nephew) screws to secure the graft in the tibial tunnel. [(35 male patients & 25 female). Average age 33.72 years]. In addition to the ACL, PLC screws were used to reconstruct the posterior cruciate ligament in one case and posterior cruciate ligament with the posterolateral corner in another three patients. Hamstring autografts were routinely preferred except in multiple ligament reconstructions, when allografts were also used.

25 (41.67%) patients presented with complications (synovitis in 10 patients, prominent tibial swelling in 21 patients and both in 7 patients). In comparison, no complications were noted in 60 other age and sex matched patients in whom PLLA (Bio RCI; Smith & Nephew) screws were used by the same surgeon.

The symptoms in the PLC screw group often settled conservatively and did not affect knee stability. 6 patients underwent exploration of the tibial tunnel site. A sterile white cheesy substance was noted which was removed, leaving an empty tibial tunnel. The ACL graft was found to be well attached to tibial tunnel in all cases. The PLC screw size did not have any correlation to the occurrence of complications. 2 patients required multiple washouts, one of whom developed a deep infection.

Conclusion: The degradation of PLC screws does not follow the gradual and controlled pattern demonstrated in the ovine model [Walsh WR et all, Arthroscopy. 2007 Jul;23(7):757–65. Comparison of PLLA and PLC interference screws in an ovine ACL reconstruction model.]. The unpredictable screw resorption, and the reaction to it can lead to serious clinical consequences.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 418 - 418
1 Sep 2009
Konan S Haddad F
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Purpose of study: The all inside fixation of meniscal tears with bio-degradable products is popular because of its fast application and reduction in risks of serious neurovascular complications. We reviewed the results of a consecutive series of all inside meniscal repairs performed by the senior author in a carefully selected patient population.

Materials & Results: The senior author performed 104 consecutive meniscal repairs (54 lateral & 50 medial meniscus) in 96 patients (66 male, 30 female), using all inside meniscal repair systems (18 Bionxx, 86 FasT Fix; Smith & Nephew). The average patient age at the time of repair was 31.6 years (range 17 – 46 years). On an average 2 arrows (range 1–4) were used in the Bionnx system and 2.5 sutures (range 1–7) for the Fas T fix system. The predominant tear pattern was a peripheral red on white type tear involving the body and posterior horn. Concomitant ACL reconstruction was undertaken in 50% cases. In 26.9 % cases the repaired meniscus was partially trimmed prior to repair and in 25 % cases a tear of the non repaired meniscus was stabilised by trimming alone. A further arthroscopic partial menisectomy was performed in 12 cases of failed repair (4 Bionxx, 8 Fas T fix) at an average of 16.16 months (range 1 month – 44 months). None of the other patients had symptoms or signs suggestive of meniscal pathology on follow up (minimum 12 months). The repair was successful in 90.69 % of Fas T fix repairs and 77.78 % of Bionxx repairs. The meniscal repair failure rate in the group which had an ACL reconstruction was 5.77 %. No major intra or post operative complications were noted.

Conclusion: Successful meniscal preservation is feasible by using an all-inside meniscal repair device. Patient selection and due consideration to the site and geometry of the meniscal tear is crucial.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 425 - 425
1 Sep 2009
Konan S Rayan F Haddad F
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Purpose of study: The diagnosis of meniscal tears is usually based on the patient’s history and on specific physical tests. Magnetic resonance imaging (MRI) and arthroscopy is often necessary for diagnosis.

Theofilos Karachalios et al. described the new ‘Thessaly test’ and concluded that it could be safely used as a first line screening test for the selection of patients who need arthroscopic meniscal surgery (Ref: J Bone Joint Surg Am. 2005 May; 87(5):955–62). Our objective was to study the role of physical diagnostic tests in screening for meniscal tears and to validate the diagnostic accuracy of the Thessaly test.

Methods & Results: We examined 109 patients [(80 male, 29 female), average age 39.11 years, range (16–66)] who presented with a history suggestive of a meniscal tear. Joint line tenderness,

McMurray’s test and the Thessaly test were assessed by an independent investigator blinded to any imaging data in all patients. MRI and subsequent arthroscopy results were then collated.

Our study showed a much lower diagnostic accuracy for the Thessaly test (61.25 % for medial meniscus and 80 % for lateral meniscus) It is comparable to McMurray’s test (57.14 % for medial meniscus and 77.38 % for lateral meniscus). The Joint line tenderness test has a far superior diagnostic accuracy (80.95 %for medial meniscus and 90.48 % for lateral meniscus). Combining the joint line tenderness test with McMurrays test or the Thessaly test further increased the diagnostic accuracy. Magnetic resonance imaging (MRI) detected 96% of meniscal tears. Arthroscopy was diagnostic and therapeutic in all cases.

Conclusion: Physical tests may not always be diagnostic of meniscal tears. MRI and arthroscopy may be essential in dubious clinical presentations. In our study the Thessaly test in isolation did not have the highest diagnostic accuracy for the detection of meniscal tears but helps increase diagnostic certainty when combined with standard tests.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 9 | Pages 1125 - 1126
1 Sep 2009
Oussedik S Haddad F

Recent publication of reports showing high revision rates for hip and knee replacements carried out in Independent Sector Treatment Centres (ISTCs) has raised doubts regarding their ability to provide high quality healthcare. The high revision rates also create a financial burden to the NHS. The poor quality of data collected at ISTCs makes their performance difficult to evaluate. Funds may be better spent improving existing NHS facilities rather than establishing parallel ISTCs.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 105 - 105
1 Mar 2009
Dodd M Haddad F Rayanmarakkar F
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The incidence of post-operative peri-prosthetic fractures is increasing. This is a consequence of the larger number of revision cases being undertaken, the increase in the use of cementless implants and a number of patients who develop undetected osteolysis as a result of poor follow up. The Vancouver classification has been shown previously, in North America, to be a valid and reliable method for determining the configuration of a periprosthetic fracture. This is essential in directing the fractures further management appropriately and the classification system has been adopted by surgeons throughout the world.

The reliability of any classification system depends on the reproducibility between the clinicians who are making the management decisions. We have revalidated this classification system, independently from the original authors, at a centre in Europe. The radiographs from 30 patients with peri-prosthetic fractures were reviewed by 6 expert consultant surgeons, 6 non-experts at registrar level and 6 medical students, who had received no specialist teaching in this area, in order to assess intra and inter-observer reliability and reproducibility. Each observer read the radiographs on 2 separate occasions and classified the fracture according to its type (A, B1, B2, B3, and C). The results were subjected to weighted kappa analysis and were: 0.76 (substantial agreement) for experts; 0.68 (substantial agreement) for non-experts; and 0.61 (substantial agreement) for medical students.

Our results confirm the reliability and reproducibility of this classification system. In addition we have shown that substantial agreement can even be found between individuals with no specialist training. This is a classification system that can be reliably used by non-experts, between centres and across continents.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 128 - 128
1 Mar 2009
Ashby E Davies M Wilson A Haddad F
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Aims: To determine the rate of orthopaedic wound infection using ASEPSIS and compare this to the rate of infection as defined by the US Centres for Disease Control (CDC) and the UK Surgical Site Infection Surveillance Service (SSISS).

Background: It is a common misconception that reported rates of orthopaedic wound infection are accurate, reliable and reproducible. Most definitions of infection, including CDC and SSISS, are subjective and depend on the interpretation of the surgeon. ASEPSIS1 is a method of wound scoring which grades wounds as uninfected, disturbed healing, minor infection, moderate infection and severe infection. ASEPSIS scoring has been proven to be both objective and repeatable2.

Method: Over 4 years, 1113 orthopaedic wounds were prospectively evaluated using the CDC definition for surgical site infections, the SSISS definition and the ASEPSIS scoring method. Patients were seen pre-operatively and at 3 and 5 days post-operatively. They also completed a wound surveillance questionnaire at 2 months post-discharge.

Results: The overall infection rates were 8% as defined by CDC, 4% as defined by SSISS and 3% as defined by ASEPSIS. Further classification of the wounds as defined by ASEPSIS revealed that 91% of wounds showed no evidence of infection (score < 10), 6.6% showed a disturbance of healing (score 11–20), 2.3% had a minor infection (score 21–30), 0.4% had a moderate infection (score 31–40) and 0.3% had severe infection (score > 40).

Conclusion: This study illustrates that accurate wound surveillance is not simple. Different wound infection definitions give very different rates of infection and make comparisons between surgeons and hospitals impossible.

We propose that ASEPSIS provides the most accurate and reproducible results and also provides more information with the grading of wound infection. The overall rate of orthopaedic wound infection using the ASEPSIS method is 3%. If all hospitals used this scoring method, more accurate comparisons of infection rates could be made.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 548 - 548
1 Aug 2008
Soler JA Haddad F Barrack RL
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Introduction: Third generation fixation systems allow for the retightening of cables, and are associated with high rates of trochanteric union. This is a prospective study undertaken to evaluate the outcome of the first 40 patients treated with a third generation cable plate and trochanteric hook system.

Methods: 36 patients treated by two revision hip arthroplasty surgeons using a third generation cable plate system were enrolled and followed up. These included 28 females and 12 males with an average age of 64 (range: 48–91). Large hooks were used in 30 with an average of 4.8 cables (range: 4–9). The need to retighten cables intra-operatively was noted. Clinical and radiographic follow-up was undertaken at 2 years.

Results: A third generation fixation system was used for 16 peri-prosthetic fractures, 6 trochanteric non unions, 5 structural femoral allografts, 6 complex revisions and for trochanteric advancement in 3 cases. The first cable tightened was loose by the end of the procedure in the majority of cases and had to be retightened. There were no cases of fretting or cable breakage. Two further trocanteric non unions needed re-fixation and bone grafting in a further procedure

Discussion and Conclusion: Third generation cable system allow for re-tightening, as the cable is not damaged by the crimping mechanism. This facility appears critical as some retightening is invariably required in the process of applying this type of device. There were only 2 re-operations for trochanteric non unions, but the overall outcomes were otherwise excellent, with no fretting or cable breakage. Modern cable systems afford improved, more flexible trochanteric fixation possibilities.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 7 | Pages 952 - 956
1 Jul 2008
Haddad F Chemali R Maalouf G

Dysplasia epiphysealis hemimelica of the left proximal femur was diagnosed in an eight-month-old girl. At the age of 18 months, radiographs of the hip and MRI showed overgrowth and loss of containment of the femoral head. She underwent resection of the superior portion of the head and neck of the femur at the age of 2.5 years. Six months later further radiographs and an MR scan show that the mass has increased in size and that hip containment has been lost. Further plain radiographs have shown that the left knee, ankle and spine were involved.

To the authors’ knowledge, this is the first report of dysplasia epiphysealis hemimelica involving both the lower limb and the spine. A review of the literature is presented.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 338 - 339
1 Jul 2008
Waheed A Eleftheriou K Khairandish H Hussein A James L Montgomery H Haddad F Simonis R
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The aetiology and pathophysiology of non-union is still unclear, but in this condition there is an abnormal bone metabolism. The paracrine matrix RAS has been implicated in the regulation of bone remodeling and injury responses, possibly via its effects on kinins. The influence of the local RAS or the genetic influence of the ACE/ BK2R genes to bone remodelling may thus be central to the disorder, or augmented in these conditions. We thus compared the distribution of the ACE I/D and BK2R “+9/-9” functional polymorphisms in patients with non-union and compared them to appropriate control.

Gene analysis was performed on buccal cells collected from all subjects and the data was analysed for 59 patients (46 males, 13 females; mean age 40.1±15.7 years) with non-union and 81 control subjects (49 males, 32 females; mean age 51.4±22.81 years. The overall genotype distribution was consistent with Hardy-Wein-berg equilibrium for the overall and individual groups for ACE (p0.16), B1BKR (p0.68) and B2BKR genotypes (p0.12)

As the -9 allele is associated with greater gene transcription and higher mRNA expression of the receptor we combined the -9/-9 homozygous and -9/+9 heterozygous groups and compared them with the homozygous +9/+9 groups. This showed a significant difference between the non-union and control groups, with the +9/+9 homozygous being less prominent in the former (p=0.03)

The B2BKR -9 allele is associated with the incidence of non-union in fracture healing, in this first study to address this question. We found no association with either the ACE I/D or B1BKR genotypes.

In conclusion, with previous findings that the absence of the -9 allele of the B2BKR +9/-9 polymorphism is associated with greater gene transcription and higher mRNA expression of the receptor our findings are suggestive that increased BK activity via the B2BKR may predispose to the development of non-union.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 17 - 18
1 Mar 2008
Patel R Stygall J Harrington J Harrison M Newman S Haddad F
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To quantify the intraoperative cerebral microemboli load during primary total knee arthroplasty (TKA) using transcranial Doppler ultrasound and to investigate whether a patent foramen ovale influences cerebral embolic load in general.

Patients undergoing primary TKA, with no history of stroke, TIA, ongoing CNS disease or alcoholism were included. All operations were carried out under a standardised general anaesthetic and performed by two consultant orthopaedic surgeons. Microemboli l oad was recorded, using transcranial Doppler ultrasound (TCD), onto VHS tape for subsequent playback and analysis. Patent foramen ovale detection was performed using bolus intravenous injection of agitated saline followed by valsalva manoeuvre technique and TCD. Timing of specific surgical steps was recorded for each operation and emboli load calculated for that period.

Results: 50 TKA patients were studied (31 females, 19 males); 28 right and 22 left TKAs were performed. Cerebral microembolisation occurred in 19 patients (42%). Mean microembolic load was 3.56 per patient (range 0–21). PFO was detected in 9 patients (18%). Two thirds of PFO positive patients displayed cerebral microemboli. However, 36.6% (n=15) of PFO negative patients also displayed microemboli intraoperatively. Deflation of the tourniquet was followed by a larger microembolic load than the other phases of the operation.

Conclusion: Intraoperative cerebral microembolisation occurs in a significant proportion of patients during total knee arthroplasty. The presence of a patent foramen ovale does not appear to influence the incidence microemboli intraoperatively. Specific surgical activities are associated with generating greater embolic loads. These questions will be comprehensively assessed in the larger study currently underway.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 11 - 12
1 Mar 2008
Tsiridis E Narvani A Haddad F Timperley J Gie G
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To assess the outcome of periprosthetic femoral fractures (Vancouver B3 type) around loose stems treated by impaction grafting revision, 106 B3 fractures were reviewed. To assess the association between those who healed and those who did not for the factors of interest such as stem length, impaction grafting and the combination of the above, odd ratios along with their 95% CI and their p-values were reported. Logistic regression in STATA version 7.0 employed.

75 out of 89 fractures treated with long stem revision and 10 out of 17 with sort stem healed. 74 out of 89 fractures treated with impaction grafting and 11 out of 17 treated without impaction grafting healed.

66 out of 75 fractures treated with long stem and impaction grafting and 9 out of 14 treated with with long stem but no impaction grafting healed. 8 out of 14 fractures treated with short stem and impaction healed. Average healing 8.5 months.

Those treated with long stem are almost four times more likely to heal than those treated with short stem (odds ratio = 3.75 95%CI: 1.21–11.6 p=0.022) and those with impaction grafting are also more likely, but not statistically significant, to heal than those without impaction grafting (odds ratio = 2.69, 95%CI: 0.86– 8.45 p=0.090). Furthermore, those with long stem and impaction are significantly more likely to heal than those without impaction grafting and those with short stem and impaction grafting (odds ratios = 4.07, 95%CI: 1.10 – 15.0 p=0.035 and 5.5, 95%CI: 1.54 – 19.6 p=0.009 respectively).

Impaction grafting is an increasingly popular technique for the restoration of femoral bone stock. It can successfully be applied to periprosthetic femoral fractures but a long stem should be used to bypass the distal fracture line.