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Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 307 - 307
1 May 2010
Pandit H Glynjones S Gundle R Gibbons C Mclardy-Smith P Whitwell D Athanasou N Gill H Murray D
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Introduction: We report on a group of 20 metal-onmetal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms; these masses we termed pseudotumours.

Methods: All patients underwent plane radiography; CT, MRI and ultrasound investigations were also performed for some patients. Where samples were available histology was performed. Metal ion levels were measured in six patients and one patient had the metal ion levels in the joint fluid measured.

Results: All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. In all cases a soft tissue mass was present in the region of the hip, this was either solid or cystic. The common histological features were extensive necrosis and lymphocytic infiltration. The blood cobalt and chromium levels varied considerably between the six patients that had these measurements. The median blood chromium level was 3.8 μg/L (range 0.8 to 23 μg/L) and that for cobalt was 11.5 μg/L (range 2.1 to 15 μg/L). The synovial fluid sample taken from a single joint contained much higher metal levels, 701 μg/L for chromium and 329 μg/L for cobalt. Twelve of the 20 cases have so far required revision to a conventional hip replacement.

Discussion: This complication is best imaged with ultrasound, and is not detected by normal xray. We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years. The cause of these pseudotumours is unknown and is probably multifactorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudo-tumours will increase.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 274 - 274
1 May 2010
Pandit H Steffen R Gundle R Mclardy-Smith P Marks B Beard D Gill H Murray D
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Introduction: Although resurfacing hip replacements are widely used there are few little independent outcome data to support this. The aim of this study was to report the 5 year clinical outcome and 7 year survival of an independent series.

Method: 610 Birmingham hip resurfacings were implanted in 532 patients with an average age of 51.8 years (range 16.5–81.6 years) and were followed for between 2 to 8 years; 120 of this series had minimum five year follow-up. Two patients were lost. There were 23 revisions, giving an overall survival of 95% (95% CI 85–99%) at seven years. Fractured neck of femur (n=13) was the most common reason for revision, followed by aseptic loosening (n=4). There were also 3 patients who had failures that were possibly related to metal debris. At a minimum of 5 year follow-up 93% had excellent or good outcome according to the Harris Hip Score. The mean Oxford Hip Score was 16.1 points (SD 7.7) and the mean UCLA activity score was 6.6 points (SD 1.9). There were no patients with definite evidence of radiographic loosening or greater than 10% of neck narrowing.

Discussion: The results demonstrate that with the Birmingham Hip Resurfacing, implanted using the extended posterior approach, the five year survival is similar or better to the reported survival rates for cemented and hybrid THR’s in young patients.

Conclusions: Considering these patients are young and active these results are good and support the use of resurfacing. However, further study is needed to address the early failures; particularly those related to fracture and metal debris.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 414 - 414
1 Sep 2009
Simpson D Pandit H Gulati A Gray H Beard D Price A Murray D Gill H
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Statement of purpose: The aim of this study is to evaluate different designs of unicompartmental knee replacement (UKR) by comparing the peak von Mises and contact stresses in polyethylene (PE) bearings over a step-up activity.

Summary of Methods: A validated finite element (FE) model was used in this study. Three UKR designs were modelled: a spherical femoral component with a spherical PE bearing (fully-congruent), a poly-radial femoral component with a concave PE bearing (semi-congruent), and a spherical femoral component with a flat bearing (non-congruent).

Kinematic data from in-vivo fluoroscopy measurements during a step-up activity was used to determine the relative tibial-femoral position as a function of knee flexion angle for each model. Medial and lateral force distribution was adapted from loads measured in-vivo with an instrumented implant during a step-up activity. The affect that varying the bearing thickness has on the stresses in the bearing was investigated. In addition, varus-valgus mal-alignment was investigated by rotating the femoral component through 10 degrees.

Summary of Results: Only the fully congruent bearing experienced peak von Mises and contact stresses below the PE lower fatigue limit (17MPa) for the step-up activity (fully congruent PE peak contact stress, 5MPa). The highest PE contact stresses were observed for the semi-congruent and non-congruent designs, which experienced approximately 3 times the PE lower fatigue limit. Peak PE von Mises stresses for the semi-congruent and non-congruent designs were similar, peaking at approximately 25MPa. Peak PE von Mises stresses were ameliorated with increased bearing thickness. Varus-valgus mal-alignment had little effect on the peak stresses in the three UKR designs.

Statement of Conclusions: Fully congruent articulating surfaces significantly reduce the peak contact stresses and von Mises stresses in the bearing. The FE model demonstrates that fully congruent bearings as thin as 2.5mm can be used without increasing the contact stresses significantly. Fully congruent designs can use thinner bearings and enable greater bone preservation.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 412 - 412
1 Sep 2009
Pandit H Jenkins C Gill H Beard D Marks B Price A Dodd C Murray D
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Introduction: The results of the mobile bearing Oxford unicompartmental knee replacement (UKR) in the lateral compartment have been disappointing with a five year survival of 82%. Therefore, it is recommended that mobile bearings should not be used for lateral UKR. This low survivorship is primarily due to high dislocation rate, all occurring in the first year. A detailed analysis of the causes of bearing dislocation confirmed the elevated lateral tibial joint line to be a contributory factor. A new surgical technique was therefore introduced in which care was taken neither to remove too much bone from the distal femur nor to over tighten the knee and therefore ensure that the tibial joint line was not elevated. Other modifications to the technique were also introduced including use of a domed tibial component.

Aim: The aim of this study is to compare the outcome of these iterations: the original series [series I], Series II with improved surgical technique and the domed tibial component [Series III].

Method: The primary assessment of outcome was bearing dislocation at one year. One year was chosen as all the dislocations in the first series occurred within a year. In series I, there were 53 knees, in series II 65 knees and in series III 60 knees, all with a minimum of one year follow up.

Results: In series I, there were 6 bearing dislocations (11%) and the average range of movement (ROM) was 110°. In the second series, there were 2 dislocations (3%) and the average ROM was 118°. In the third series, there were no primary dislocations and the average ROM was 125°.

Conclusions: The improved surgical technique and implant design has reduced the dislocation rate to an acceptable level so a mobile bearing can now be recommended for lateral UKR.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 500 - 500
1 Sep 2009
Monk P Pandit H Gundle R Whitwell D Ostlere S Athanasou N Gill H McLardy-Smith P Murray D Gibbons C
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We report on a group of 20 metal-on-metal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms. We describe these masses as pseudotumours.

All patients underwent plain radiography and fuller investigation with CT, MRI and ultrasound. Where samples were available, histology was performed. All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, an enlarging mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. Fourteen of the 20 cases (70%) have so far required revision to a conventional hip replacement and their symptoms have either settled completely or improved substantially since the revision surgery. Two of the three bilateral cases have asymptomatic pseudotumours on the opposite side.

We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years after a hip resurfacing. The cause of these pseudotumours is unknown and is probably multi-factorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudotumours will increase.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 411 - 411
1 Sep 2009
Jenkins C Barker K Pandit H Dodd C Murray D
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The purpose of this study was to determine if a single physiotherapy intervention would enable patients to kneel following Unicompartmental knee arthroplasty (UKA).

Kneeling is an important functional activity that is frequently not performed after knee arthroplasty, thus affecting a patient’s ability to carry out basic tasks of everyday life. There is however no clinical reason why patients should not kneel and many with proposed knee surgery ask about the possibility of kneeling after their operation.

Sixty adults participated in a prospective randomised controlled trial with blinded assessments. At 6 weeks post-operatively UKA patients were randomised to either the Routine care group where no advice on kneeling was given or to the Kneeling intervention group where participants were taught and given advice on how to kneel and were encouraged to do so. They were re-assessed at 1 year. The primary outcome measure was Question 7 of the Oxford Knee Score which asks the question “Could you kneel down and get up again afterwards?”

Pre-operatively there was no difference in the kneeling ability of the two groups. At 1 year the difference in kneeling ability between the two groups was highly significant (p< 0.05). Spearman’s correlation coefficient showed no significant association between a change in score of Question 7 at 1 year and the following factors; scar position, numbness, range of flexion, arthritic involvement of other joints and pain. Linear regression analysis also confirmed that these factors were not successful in predicting a change in kneeling ability.

This study showed that the single factor predictive of kneeling ability was the physiotherapy intervention provided at 6 weeks post-operatively and it is suggested that kneeling should be incorporated into patient’s post-operative rehabilitation programmes.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 412 - 412
1 Sep 2009
Pandit H van Duren B Jenkins C Gill H Beard D Price A Dodd C Murray D
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Introduction: Treatment options for the young active patient with isolated symptomatic medial compartment OA and pre-existing ACL deficiency are limited. Implant longevity and activity levels may preclude TKA, whilst HTO and unicompartmentasl knee arythroplasty (UKA) are unreliable due to ligamentous instability. UKAs tend to fail because of wear or tibial loosening resulting from eccentric loading. Combined UKA and ACL reconstruction may therefore be a solution.

Method: Fifteen patients with combined ACL reconstruction and Oxford UKA (ACLR group), were matched (age, gender and follow-up period) with 15 patients with Oxford UKA with intact ACL (ACLI group). Prospectively collected clinical and x-ray data from the last follow-up (minimum 3 years, range: 3 – 5) were compared. Ten patients from each group also underwent in-vivo kinematic assessment using a standardised protocol.

Results: At the last follow-up, the clinical outcome for the two groups were similar. One ACLR patient needed revision due to infection. Radiological assessment did not show any significant difference between relative component positions and none of the patients had pathological radiolucencies suggestive of component loosening. Kinematic assessment showed posterior placement of the femur on tibia in extension for the ACLR group, which corrected with further flexion.

Conclusions: The short-term clinical results of combined ACL reconstruction and UKA are excellent. Lack of pathological radiolucencies and near normal knee kinematics suggest that early tibial loosening due to eccentric loading is unlikely.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 426 - 426
1 Sep 2009
McDonnell S Thomas G Rout R Osler S Pandit H Beard D Gill H Dodd C Murray D Price A
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Aim: The aim of this study was to asses the accuracy of skyline radiographs in the assessment of the patellofemoral joint, when compared to open intraoperative assessment.

Methods: Eighty nine patients undergoing knee replacement surgery were included in the study. Skyline radiographs were obtained preoperatively. These radiographs were assessed and graded by an experienced musculoskeletal radiologist using the Altman and Ahlbäck classifications. The grades were calculated for both the medial and lateral facets of the PFJ. Intraoperative assessment of the Patellofemoral joint was undertaken at the time of surgery. The damage was graded using the modified Collins classification (0: Normal, 1: Superficial damage, 2: Partial thickness cartilage loss, 3: Focal Full thickness cartilage loss < 2cm2, 4: Extensive full thickness cartilage loss < 2cm2). Data was obtained for the Medial Facet, Lateral Facet and Trochlea.

Results: Spearman’s rank correlation coefficient between the radiographic and macroscopic changes within the lateral PFJ were poor with both the Altman 0.22 (p=0.0350) and Ahlbäck 0.24 (p=0.018). The correlation of the medial PFJ was slightly better with a coefficient for Altman 0.42 (P< 0.0001) and Ahlbäck 0.34 (P> 0.001).

Conclusion: In conclusion skyline radiographs provide a poor to moderate preoperative assessment of the degree of osteoarthritis within the patella-femoral joint. This has significant implications for establishing radiographic criteria for planning patella-femoral joint replacement.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 410 - 410
1 Sep 2009
Longino D Hynes S Rout R Pandit H Beard D Gill H Dodd C Murray D Cooper C Javaid M Price A
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Purpose: The aim of this study is to compare the long-term survival results of TKA in patients under the age of 60, using

revision surgery and

poor functional outcome as the end-points.

Method: From our knee database we identified a cohort of 60 total knee replacements that had been performed over 15 years previously. We identified those who had died, those who had been revised and established the Oxford Knee Score (OKS) for all those still surviving.

Results Using the following endpoint criteria the cumulative 15-year survival was (A) revision surgery alone = 78% (CI 12), (B) revision surgery or an OKS less than or equal to 24 (50% of total OKS) = 63% (CI 13), and (C) revision surgery or moderate pain = 48% (CI 14).

Conclusion The functional survival of TKA in patients under the age of 60 decreases in the second decade following implantation with a significant number of prostheses failing the patient due to knee pain


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 412 - 412
1 Sep 2009
Pandit H Jenkins C Beard D Gill H Marks B Price A Dodd C Murray D
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Introduction: The information in the literature about the relative merits of cemented and cementless unicompartmental knee replacement (UKR) is contradictory, with some favouring cementless fixation while others favouring cemented fixation. Cemented fixations give good survivorship but there is concern about the radiolucency which frequently develops around the tibial component. The exact cause of the occurrence of radiolucency is unknown but according to some, it may suggest suboptimal fixation.

Method: Sixty-two knees (31 in each group) were randomised to receive either cemented or cementless UKR components. The components were similar except that the cementless had a porous titanium and hydroxyappatite (HA) coating. Patients were prospectively assessed by an independent observer pre-operatively and annually thereafter. The clinical assessment included Oxford Knee Score, Knee Society Scores and Tegner activity score. Fluoroscopically aligned radiographs were assessed for thickness and extent of radiolucency under the tibial implant.

Results: At one year there were no differences in the clinical outcome between the groups and there were no loose components. No radiolucencies thicker than 1mm were seen. At one year none of the cementless tibias and 30% of the cemented tibias had complete radiolucencies. One out of 31 cementless (3%) and 12 out of 31 cemented (39%) had partial radiolucencies. This difference between these two groups was high significant (p< 0 0001).

Conclusions: This study clearly demonstrates that the incidence of radiolucency beneath the tibial component is influenced by component design and method of fixation. With identical designs of tibial component none of the cementless components developed complete radiolucences whereas 30% of the cemented components did. We conclude that HA achieves better bone integration than cement.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_III | Pages 406 - 406
1 Sep 2009
Pandit H Glyn-Jones S Gundle R Whitwell D Gibbons C Ostlere S Athanasou N Gill H McLardy-Smith P Murray D
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Introduction: We report on a group of 20 metal-on-metal resurfaced hips (17 patients) presenting with a soft tissue mass associated with various symptoms; these masses we termed pseudotumours. All patients underwent plane radiography; CT, MRI and ultrasound investigations were also performed for some patients. Where samples were available histology was performed.

Methods: All patients in this series were female. Presentation was variable; the most common symptom was pain or discomfort in the hip region. Other symptoms included spontaneous dislocation, nerve palsy, a noticeable mass or a rash. The common histological features were extensive necrosis and lymphocytic infiltration. Fourteen of the 20 cases (70%) have so far required revision to a conventional hip replacement and their symptoms have either settled completely or improved substantially since the revision surgery. Two of the three bilateral cases have asymptomatic pseudotumours on the opposite side.

Conclusions: We estimate that about 1% of patients develop a pseudotumour in the first five postoperative years after a hip resurfacing. The cause of these pseudotumours is unknown and is probably multi-factorial, further work is required to define this; they may be manifestations of a metal sensitivity response. We are concerned that with time the incidence of these pseudotumours will increase.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 47 - 47
1 Mar 2009
van Duren B Pandit H Gallagher J Beard D Dodd C Gill H Murray D
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Introduction: Treatment options for the young active patient with isolated symptomatic medial compartment osteoarthritis and pre-existing anterior cruciate ligament (ACL) deficiency are limited. Implant longevity and activity levels may preclude total knee arthroplasty (TKA), whilst high tibial osteotomy HTO and unicompartmental arthroplasty (UKA) are unreliable due to ligamentous instability. UKA’s tend to fail because of wear or tibial loosening resulting from eccentric loading. Combined UKA and ACL reconstruction may therefore be a solution.

Method: Fifteen patients with combined ACL reconstruction and Oxford UKA (ACLR group), were matched (age, gender and follow-up period) with 15 patients with Oxford UKA with intact ACL (ACLI group). Prospectively collected clinical and x-ray data from the last follow-up (minimum 3 years, range: 3–5) were compared. Ten patients from each group also underwent in-vivo kinematic assessment using a standardised protocol.

Results: At the last follow-up, the clinical outcome for the two groups were similar (ACLR: OKS 46, KSS (objective): 99, ACLI: OKS 43, KSS (objective): 94). One ACLR patient needed revision due to infection. Radiological assessment did not show any significant difference between relative component positions and none of the patients had pathological radiolucencies suggestive of component loosening. Kinematic assessment showed posterior placement of the femur on tibia in extension for the ACLR group, which corrected with further flexion.

Conclusions: The short-term clinical results of combined ACL reconstruction and UKA are excellent. Lack of pathological radiolucencies and near normal knee kinematics suggest that early tibial loosening due to eccentric loading is unlikely. Similarly, wear is unlikely to be a problem because of the wear resistance of mobile bearing devices.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 47 - 48
1 Mar 2009
van Duren B Gallagher J Pandit H Beard D Dodd C Gill H Murray D
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Introduction: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range and increased medial compartment pain than seen with its medial counterpart due to, in part, the inadequacy of a flat tibial tray replacing the domed anatomy of the lateral tibia. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to overcome these problems.

This study reports a clinical comparison of new and old establishing whether this modified implant has maintained the established normal kinematic profile of the Oxford UKR.

Method: Patients undergoing lateral UKR for OA were recruited for the study. Fifty one patients who underwent UKR with the domed design were compared to 60 patients who had lateral UKR with a flat inferior bearing surface. Kinematic evaluation was performed on 3 equal subgroups (n = 20); Group 1-Normal volunteer knees, Group 2-Flat Oxford Lateral UKR’s and Group 3-Domed Oxford Lateral UKR’s. The sagittal plane kinematics of each knee was assessed using videofluoroscopic analysis whilst performing a step up and deep knee bend activity. The fluoroscopic images were recorded digitally, corrected for distortion using a global correction method and analysed using specially developed software to identify the anatomical landmarks needed to determine the Patella Tendon Angle (PTA) (the angle the patella tendon and the tibial axis).

Knee kinematics were assessed by analysing the movement of the femur relative to the tibia using the PTA.

Results: PTA/KFA values, for both devices, from extension to flexion did not show any significant difference in PTA values in comparison to the normals as measured by a 3-way ANOVA. The Domed implant achieved higher maximal active flexion during the lunge exercise than those with a flat implant. Only 33% of the flat UKR’s achieved KFA of 130° or more under load whilst performing a lunge, compared with 75% of domed UKR’s and 90% of normal knees. No flat UKR achieved a KFA of 140° or more, yet 50% of all domed UKR’s did, as did 60% of all normal knees.

Conclusions: There was no significant difference in sagittal plane kinematics of the domed and flat Oxford UKR’s. Both designs had favorable kinematic profiles closely resembling that of the normal knee, suggesting normal function of the cruciate mechanism. The domed knees had a greater range of motion under load compared to the flats, approaching levels seen with the normal knee, suggesting that limited flexion for the flat plateau results from over tightening in high flexion and that this is corrected with the domed plateau. Problems with the second generation of lateral Oxford UKA have been rectified by a new bi-concave bearing without losing bearing stability and normal kinematics.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 531 - 532
1 Aug 2008
Barker KL Newman MA Pandit H Murray DW
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Introduction: Metal-on-metal hip resurfacing arthroplasty (HRA) is currently recommended for younger, active patients with high expectations but information about outcomes is limited. Reports concentrate on wear, fracture rates and radiographic appearance, rather than function. Studies that report function do not describe rehabilitation protocols. This data is important to discussions about likely outcomes and restrictions prior to consent and to fully evaluate HRA.

Methods: Consecutive Conserve HRA operations were reviewed 1 year post-surgery. Function was assessed using 3 validated questionnaires; the OHS (Oxford Hip Score), HOOS (Hip Disability and Osteoarthritis Outcome Score) and UCLA Activity Scale. Complications, pain, ROM, muscle strength, single leg stand, walking and stair climbing ability were recorded.

Results: 125 HRA were reviewed (68 right, 57 left hips) in 120 patients (71 male, 49 female) of mean age 56 years. 86.7% recorded no complications, but 20% had pain at 3 months. The median OHS was 15, median UCLA 7 (active) and mean HOOS 82.78%. Operated hip flexors, extensors and abductors were weaker (p=0.000) and hip flexion ROM a mean 94.46 ± 12.71 (55–120) degrees. For 25% walking was limited, 7.6% needed a stick and 10% a stair rail. The OHS correlated with HOOS pain subscale (r=0.812, p=0.000), flexion ROM (r=0.426, p=0.000), hip extensor (r=0.359, p=0.000) and abductor (r=0.424, p=0.000) strength. Pain at 3 months correlated with the HOOS pain subscale (p=0.000, r= 0.503).

Discussion: Although outcomes were generally good with few complications, high levels of function and activity 25% had poor outcomes; with pain, restricted hip flexion, decreased strength, limited walking and functional problems, particularly putting on socks. Pain present at 3 months was associated with pain and worse function at 1 year. It is postulated this sub-optimal recovery may be related to current rehabilitation protocols adopted from THA and not tailored to HRA.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 384 - 384
1 Jul 2008
Gallagher J Van Duren B Pandit H Beard D Gill H Dodd C Murray D
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Background: The Oxford unicompartmental knee replacement (UKR) use in the lateral compartment has been associated with a reduced flexion range, increased medial compartment pain and a higher dislocation rate than seen with its medial counterpart due to the inadequacy of a flat tibial tray replacing the domed anatomy of the lateral tibia. A new design incorporating a domed tibial component and a biconcave meniscal bearing has been developed to overcome these problems. This current study was designed to establish whether this modi-fied ‘domed’ implant has maintained the established normal kinematic profile of the Oxford UKR.

Methods: The study population consisted of 60 participants from three equal groups; Group 1- Normal volunteer knees (n = 20), Group 2 – Flat Oxford Lateral UKR’s (n = 20) and Group 3 – Domed Oxford Lateral UKR’s (n = 20). The sagittal plane kinematics of each involved knee was assessed continuously using videofluoroscopic analysis. A standardised protocol of step-up and deep lunge was used to assess loadbearing range of motion during which the patella tendon angle (PTA) was measured as a function of the knee flexion angle (KFA).

Results: PTA/KFA values compared at 10 degree KFA increments from maximal extension to maximal flexion for all 3 groups did not demonstrate any statistically significant difference in PTA values between any group as measured by a 3-way ANOVA. The Domed implant achieved higher maximal active flexion during the lunge exercise than those with a Flat implant. Only 33% of the Flat UKR’s achieved KFA of 130 degrees or more under load whilst performing a lunge, compared with 75% of domed UKR’s and 90% of normal knees. No Flat UKR achieved a KFA of 140 degrees or more, yet 50% of all domed UKR’s did, as also did 60% of all normal knees.

Conclusions: There is no significant difference in the sagittal plane kinematics of the domed and flat Oxford UKR’s. Both implant designs have a favourable kinematic profile closely resembling the normal knee. The domed knees though do have a greater range of motion under load as compared to the flats, approaching levels seen with the normal knee.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 398 - 398
1 Jul 2008
Glyn-Jones S Pandit H Whitwell D Athanasou N Gibbons M
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Purpose of study: We report the results of a prospective case series of 10 patients who developed tumour-like masses following resurfacing arthroplasty

Method: Ten subjects were referred to the tumour service at the Nuffield Orthopaedic Centre with symptomatic masses around the hip, all had previously received a resurfacing arthroplasty.

We report the clinical, radiographic and histologic features of these cases.

Results: MRI and ultrasound scanning was preformed, which demonstrated masses with solid and cystic components.

Biopsy was performed and subsequent histological examination revealed a profound plasma-cell lymphocytic response associated with metal wear debris.

There were no infections in this series.

Three subjects required revision surgery.

Conclusion: Over 50,000 resurfacing arthroplasties have been implanted worldwide over the past ten years. Although the early clinical results are encouraging little is known about the long term consequences of large head metal on metal bearing surfaces. Despite this, these devices are being widely marketed and are often implanted in younger patients. Resurfacing arthroplasties are associated with high serum and urine metal ion concentrations, metal particles have also been shown to migrate along the lymphatic system. In addition, there is now evidence that high local metal ion concentrations can induce haempoietic cancers.

This study suggests that resurfacing arthoplasty can also induce a local hypersensitivity reaction in response to metal wear debris. It therefore raises new concerns regarding the long-term safety of this procedure.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 379 - 379
1 Jul 2008
Van B Pandit H Gallagher J Gill H Zavatsky A Shakespeare D Murray D
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Introduction: Restoration of predictable and normal knee kinematics after a TKR can improve the patient’s function. Traditional designs exhibit grossly abnormal kinematics with the femur subluxing posteriorly in extension and a paradoxical forward slide in flexion. In addition, the kinematics are very variable. Newer designs were intended to overcome these problems, owing to their ability to provide ‘guided motion’ of the components. The medial pivot knee uses a specifically designed articulating surface constraining the femoral component to externally rotate about an axis through the medial compartment.

This study assesses the functional in vivo kinematics of Advanced Medial Pivot (AMP) TKR and compares it to kinematics of the normal knee.

Methods: Thirteen patients with pre-operative diagnosis of primary osteoarthritis, who had undergone a knee replacement with the AMP knee at least one-year prior were recruited in this study. All had an excellent clinical outcome (as assessed by AKSS) and underwent fluoro-scopic analysis whilst performing a step up activity. Knee kinematics were assessed by analysing the movement of the femur relative to the tibia using the Patella Tendon Angle (PTA) through the range of knee flexion. This data was compared to that of thirteen normal knees.

Results: The PTA for the normal knee has a linear relationship with knee flexion. The PTA is 14 degrees in full extension and decreases to -10 degrees at 100 degrees knee flexion during a step-up exercise. Between extension and 60 degrees of knee flexion, no significant difference was found between the PTA for the normal knee and for the AMP. The PTA for AMP is significantly higher for values of knee flexion exceeding 60 degrees. The standard deviation for different values of knee flex-ion is similar to that seen in the normal knee.

Conclusions: In extension, the PTA is near normal but in flexion PTA is higher than normal suggesting that the femur is too anterior. The variability of the kinematics for AMP TKR is similar to that of the normal knee and is better than that of most other knee designs that we have studied in the past, indicating that it is a stable TKR.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 388 - 388
1 Jul 2008
Van B Pandit H Gallagher J Gill H Zavatsky A Thomas N Murray D
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Introduction: The cam-post mechanism of Posterior Stabilized Total Knee Arthroplasty (PS-TKA) should provide a constraint that limits anterior translation of the femur on the tibia in flexion and thereby ensure femoral roll-back with progressive knee flexion. In a previous fluoroscopic study we showed that the sagittal plane kinematics of a PCL substituting TKA (Scorpio PS) was abnormal in flexion, suggesting inefficiency of the cam-post mechanism. We also assessed the movement of the femur relative to the tibia using the Patella Tendon Angle (PTA) through the range of knee flexion (0 to 90 degrees). The aim of the current study was to investigate in greater detail why the cam-post mechanism was ineffective by assessing the contact point movement and the distance between the cam and post.

Method: Twelve patients with Scorpio PS TKA underwent fluoroscopic assessment of the knee during a step up exercise and a weight bearing deep knee bend. The image distortion was corrected using a global correction method and the data was analysed using a 3D model fitting technique. Having determined the component position, the minimum distance between cam and post were determined. The femoro-tibial contact positions of the medial and lateral condyles were determined relative to the mid-coronal plane of the tibial component. The PTA was calculated by measuring the angle subtended by patella tendon with the tibial axis and was plotted against knee flexion angle (KFA).

Results: The relationship between PTA and KFA was abnormal relative to the normal knee. Between extension and 60 degrees flexion there was forward movement of both medial (11 mm) and lateral (5 mm) femoral condyles. Thereafter, both condyles moved back (10 mm). The cam-post mechanism failed to engage in one case while in others it engaged between 70 to 100 degrees.

Conclusions: The 3D analysis has confirmed the preliminary findings of the previous study using the PTA and KFA relationship. Despite the cam engaging in flexion normal knee kinematics were not restored. The femoral roll-back is inadequate and starts to occur at least 20 degrees before the cam and post engage.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 164 - 164
1 Mar 2008
Fawzy E Pandit H McLardysmith P Dodd C Murray D
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The purpose of the study: to determine if Patient height-and gender could be used to predict component size With a minimally invasiveapproach for unicompartmental knee replacement.

Material and methods: One hundred x-rays of patients (44 men, 56 women), who had undergone Oxford UKR, were reviewed. The preoperative radiographs were assessed for component size using the standard template. The postoperative x-rays were reviewed to determine-whether the ideal component size had been used or if not what could be the most appropriate. Patient’s height was recorded. The proportion of patients for whom an appropriate size could be selected by either template or height measurements was calculated.

Current templating system accurately predicted the ideal size in 67%. In no case was the size incorrect by more than one size. The following size bands were set according to height. For men: size small in patients less than160 cm, medium less than 170 cm and large less than 180cm. For women: size small in patients less than 165 cm, medium less than 175cm and large less than 185 cm. Height accurately predicted the ideal size in75%. In no case was the assessment of component size incorrect by more than one size.

As the Oxford femoral component is spherical, its size is not critical and it is acceptable to use one size too large or too small. Both height and templating safely predicted an acceptable size in all cases and predicted the ideal size in about 70% > Conclusion: Gender specific height should be used to predict the component size in situations were templating is difficult as in digital x-rays orsuperimposition of the two femoral condyles, and non-standardised x-raymagnification.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 167 - 167
1 Mar 2008
Hollinghurst D Pandit H Beard D Ostlere S Dodd C Murray D
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The indications for unicompartmental knee arthroplasty (UKA) remain controversial; in particular the threshold of disease in the patellofemoral compartment is debated. Whilst some authorities ignore the condition of the patellofemoral joint, others consider pre-existing patellofemoral osteoarthritis (PFOA) a contra-indication to UKA. The aim of this study was to determine the influence of PFOA on the outcome of medial UKA.

This prospective study involved one hundred consecutive patients who had undergone cemented medial Oxford UKA (phase 3), via a minimally invasive approach, at least one year previously. Patients were divided into two groups according to the presence or absence of full thickness cartilage loss (FTCL) on the patella or trochlea at operation. A pre-operative skyline radiograph was graded using the Altman score, by an independent Musculoskeletal Radiologist. Outcome was evaluated with the Knee Society Score (AKSS) and the Oxford Knee Score (OKS, maximum 48). Groups were compared for differences in knee score and Altman grade using a one way ANOVA. Repeat analysis was performed using the presence of anterior knee pain (AKP) as the group defining variable.

There were 28 patients with FTCL, and both groups were well matched for age, gender and activity levels. Analysis showed no significant difference in post operative knee scores between groups with either the presence of FTCL or the presence of AKP pre-operatively as a factor. There was no significant difference in Altman grade between groups.

Intra-operative evidence of PFOA in patients with medial compartment osteoarthritis does not prejudice the outcome of UKA. Even the inclusion of patients with symptomatic AKP, without necessarily having PFOA, does not affect the outcome after UKA. These short results are encouraging, but longer follow up is required.