Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells

B. Liagre; S. Moalic; P. Vergne; J. L. Charissoux; D. Bernache-Assollant; J. L. Beneytout

doi:10.1302/0301-620X.84B6.0840920

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Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells

B. Liagre
S. Moalic
P. Vergne
J. L. Charissoux
D. Bernache-Assollant
J. L. Beneytout

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Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells

Liagre B, Moalic S, Vergne P, Charissoux JL, Bernache-Assollant D, Beneytout JL. Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells. J Bone Joint Surg Br. 2002;84-B(6):920-930. doi:10.1302/0301-620X.84B6.0840920

Liagre, B., et al. “Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.” The Journal of Bone & Joint Surgery British Volume, vol. 84-B, no. 6, 2002, pp. 920-930., https://doi.org/10.1302/0301-620X.84B6.0840920

Liagre, B., Moalic, S., Vergne, P., Charissoux, J. L., Bernache-Assollant, D., & Beneytout, J. L. (2002). Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells. The Journal of Bone & Joint Surgery British Volume, 84-B(6), 920-930. https://doi.org/10.1302/0301-620X.84B6.0840920

Liagre, B., Moalic, S., Vergne, P., Charissoux, J. L., Bernache-Assollant, D. and Beneytout, J. L. (2002) “Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.” The Journal of Bone & Joint Surgery British Volume, 84-B(6), pp. 920-930. Available at: https://doi.org/10.1302/0301-620X.84B6.0840920

Liagre, B., S. Moalic, P. Vergne, J. L. Charissoux, D. Bernache-Assollant, and J. L. Beneytout. “Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells.” The Journal of Bone & Joint Surgery British Volume 84-B, no. 6 (2002): 920-930. https://doi.org/10.1302/0301-620X.84B6.0840920

Liagre B, Moalic S, Vergne P, Charissoux JL, Bernache-Assollant D, Beneytout JL. Effects of alumina and zirconium dioxide particles on arachidonic acid metabolism and proinflammatory interleukin production in osteoarthritis and rheumatoid synovial cells. J Bone Joint Surg Br. 2002 Aug 1;84-B(6):920-930. https://doi.org/10.1302/0301-620X.84B6.0840920

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Abstract

We describe a model which can be used for in vitro biocompatibility assays of biomaterials.

We studied the in vitro response of human osteoarthritis or rheumatoid arthritis fibroblast-like synoviocytes to Al₂O₃ or ZrO₂ particles by analyzing the production of interleukin-1 (IL-1) and interleukin-6 (IL-6) and the metabolism of arachidonic acid via lipoxygenase and cyclo-oxygenase pathways.

Our results show that, in these cells and under our experimental conditions, Al₂O₃ and ZrO₂ did not significantly modify the synthesis of IL-1 and IL-6 or the metabolism of arachidonic acid.

Correspondence should be sent to Dr J. L. Charissoux.

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