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Bone & Joint Research
Vol. 5, Issue 7 | Pages 287 - 293
1 Jul 2016
Mesenchymal stem cell implantation in atrophic nonunion of the long bones
Ismail H Phedy P Kholinne E Djaja YP Kusnadi Y Merlina M Yulisa ND
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Objectives

To explore the therapeutic potential of combining bone marrow-derived mesenchymal stem cells (BM-MSCs) and hydroxyapatite (HA) granules to treat nonunion of the long bone.

Methods

Ten patients with an atrophic nonunion of a long bone fracture were selectively divided into two groups. Five subjects in the treatment group were treated with the combination of 15 million autologous BM-MSCs, 5g/cm3 (HA) granules and internal fixation. Control subjects were treated with iliac crest autograft, 5g/cm3 HA granules and internal fixation. The outcomes measured were post-operative pain (visual analogue scale), level of functionality (LEFS and DASH), and radiograph assessment.