Aims

To assess the alterations in cell-specific DNA methylation associated with chondroitin sulphate response using peripheral blood collected from Kashin-Beck disease (KBD) patients before initiation of chondroitin sulphate treatment.

Aims

The aim of this study was to evaluate the outcome of spinal instrumentation in haemodialyzed patients with native pyogenic spondylodiscitis. Spinal instrumentation in these patients can be dangerous due to rates of complications and mortality, and biofilm formation on the instrumentation.

Objectives

The objective of this study was to assess the association between whole body sagittal balance and risk of falls in elderly patients who have sought treatment for back pain. Balanced spinal sagittal alignment is known to be important for the prevention of falls. However, spinal sagittal imbalance can be markedly compensated by the lower extremities, and whole body sagittal balance including the lower extremities should be assessed to evaluate actual imbalances related to falls.

Objectives

Although vertebroplasty is very effective for relieving acute pain from an osteoporotic vertebral compression fracture, not all patients who undergo vertebroplasty receive the same degree of benefit from the procedure. In order to identify the ideal candidate for vertebroplasty, pre-operative prognostic demographic or clinico-radiological factors need to be identified. The objective of this study was to identify the pre-operative prognostic factors related to the effect of vertebroplasty on acute pain control using a cohort of surgically and non-surgically managed patients.

Cannulated screw is commonly used in the fixation of proximal femoral neck fractures. In the literature, several configurations had been proposed for best mechanical support with clinical experiences or biomechanical tests. Although screws in triangle configuration contribute certain fixation stability, but sometimes the surgeons made their own choices have to conduct another fixation pattern for some factors such as fracture type, economic issues, and so on. Therefore the aim of this study is to analyze the mechanical responses of a fractured femur fixed with screws in different configurations, screw materials and screw diameters with finite element method, trying to find the most stable construct.

A solid femur model was built from the CT images of a standard saw bone. Three fracture types of the femoral neck were created according to Pauwel's classification (30?, 50?, 70?) by CAD software. The models of implanted screws were built according to a commercial cannulated screw (Stryker Osteosynthesis, Schoenkirchen/Kiel, Germany) with diameter 6.5mm and 4.5mm by CAD software, too. Three fixation configurations were analyzed in this study, including triangle with superior single screw with titanium diameter 6.5mm, triangle with inferior single screw with diameter 6.5mm and diamond with four stainless screw diameter 4.5mm (fig.1). Totally there were nine models constructed in this study, and all of them were then imported into ANSYS WORKBENCH v14 (Swanson Analysis, Houston, PA, USA) to mesh and further analysis. 700N vertical downward force was applied on the femur head and the distal end of femur shaft was totally fixed.

The triangle fixation with superior single screw resulted in a best stability, but the fracture fixed with screws in a diamond configuration has least fracture gap. The difference of the maximum displacement of the femur head with Pauwel's classification 70?between triangle fixation with superior single screw and diamond configuration is only 0.03mm (1.72–1.69 mm). In most unstable femoral neck fracture [Pauwel's classification 70], the maximum gap distance is 0.59mm under the diamond configuration, while it is 0.63mm as the fracture fixed with a triangle configuration.

Therefore, this study suggests that four 4.5mm stainless screws in a diamond configuration is an alternative for proximal femur fracture once 6.5mm titanium screws are not available.

Summary Statement

Flow chambers have been implemented in stem cell research to apply controlled dilational (volume changing) and deviatoric (shape changing) mechanical cues to living cells. Studies implementing such chambers demonstrate that controlled delivery of mechanical cues correlates strongly to changes in stem cell shape, structure, and fate.

Summary Statement

Progenitor cells from the periosteal niche are of great clinical interest due to their remarkable regenerative capacity. Here we report on progenitor cells from arthritic patients whose femoral neck periosteum was resected over the course of hip replacement.

It has been suggested that extracorporeal shockwave therapy is a safe and effective treatment for pain relief from recalcitrant plantar fasciopathy (PF). However, the changes in gait and associated biomechanical parameters have not been well characterised. We recruited 12 female patients with recalcitrant PF who had a mean age of 59 years (50 to 70) and mean body mass index of 25 kg/m² (22 to 30). The patients reported a mean duration of symptoms of 9.3 months (6 to 15). Shockwave therapy consisting of 1500 impulses (energy flux density 0.26 mJ/mm²) was applied for three sessions, each three weeks apart. A pain visual analogue scale (VAS) rating, plantar pressure assessment and motion analysis were carried out before and nine weeks after first shock wave therapy. It was demonstrated that patients increased their walking velocity and cadence as well indicating a decrease in pain after shockwave therapy. In the symptomatic foot, the peak contact pressure over the forefoot increased and the contact area over the digits decreased. The total foot impulse also decreased as did stance duration. The duration the centre of pressure remained in the hindfoot increased in the symptomatic foot after shockwave therapy. The differences in centre of pressure trajectory at baseline decreased at final follow-up. In conclusion, shockwave therapy not only decreased the pain VAS rating but also improved the gait parameters of the symptomatic foot in PF patients.

Cite this article: Bone Joint J 2013;95-B:1088–93.

This study evaluates factors related to myelopathic symptoms in patients with ossification of the posterior longitudinal ligament (OPLL). A total of 87 patients with OPLL were included. Of these, 53 (Group I) had no symptoms or presented with neck pain and radiculopathy and 34 (Group II) had myelopathic symptoms. Gender, age, and history of trauma were evaluated in the two groups. The range of movement of the cervical spine was measured using plain radiographs. The number of involved segments, type of OPLL, and maximal compression ratio were analysed using CT and signal change in the spinal cord was evaluated using MRI.

The patients’ age was found to be significant (p = 0.001). No difference was found between gender and the range of movement in the two groups. The maximum compression of the spinal canal showed a difference (p = 0.03). The signal change of the spinal cord was different between the two groups. In patients with OPLL of the cervical spine, myelopathic symptoms are not related to the range of movement or the number of involved segments.

Computer based navigation system improved the accuracy of limb and component alignment and decreased the incidence of outliers. The majority of previous studies were based on the infrared navigation system. We evaluate the availability and accuracy of the electromagnectic(EM) navigation system in total knee arthroplasty

From July 2006 to January 2007, 40 patients (50 TKAs) with osteoarthritis were participated in this study. AxiEM(Medtronics) was used and Nexgen CR(26 cases), and Nexgen CR flex(24 cases) were used. We analyzed the failure mode of navigation (7 cases), operation time and radiologic results (limb and component alignment)

Total registration time was 4 minutes 45 seconds in average (Range: 3 minutes 45 seconds – 6 minutes 55 seconds). Failures in clinical applications resulted from non-recognition of EM tracker or paddle by metallic interference in 4 cases and from informational changes during surgery by fixation loss or loosening of the tracker in 3 cases. Radiologically, the mechanical axis changed from −11.2±7.21 (Range: −25.8~3.1) to 1.0±1.25(Range: −2.1~4.0) and 1 case of outlier occurred (valgus 4°). Component alignment is measured as followed: 89.3±1.6° of Theta angle, 89.9±1.5° of Beta angle, 1.8±2.5° of Gamma angle, 86.1±2.9 of Delta angle°. There were no complications related to the EM navigation.

The EM navigation system helped to achieve accurate alignment of component and lower leg axis without any complications. It had several advantages such as relatively less invasiveness in fitting small instruments, not disturbing operation field, no interrupted line of sight, portable use, and applicability to any implant. However, metallic interference may be still problematic.

The EM navigation had advantages; less invasiveness, no disturbing operation field, no interrupted line of sight, portable use and applicability to any implants. But metallic interference may be still problematic.

Bilateral sequential total knee replacement with a Zimmer NexGen prosthesis (Zimmer, Warsaw, Indiana) was carried out in 30 patients. One knee was replaced using a robotic-assisted implantation (ROBOT side) and the other conventionally manual implantation (CON side). There were 30 women with a mean age of 67.8 years (50 to 80).

Pre-operative and post-operative scores were obtained for all patients using the Knee Society (KSS) and The Hospital for Special Surgery (HSS) systems. Full-length standing anteroposterior radiographs, including the femoral head and ankle, and lateral and skyline patellar views were taken pre- and post-operatively and were assessed for the mechanical axis and the position of the components. The mean follow-up was 2.3 years (2 to 3).

The operating and tourniquet times were longer in the ROBOT side (p < 0.001). There were no significant pre- or post-operative differences between the knee scores of the two groups (p = 0.288 and p = 0.429, respectively). Mean mechanical axes were not significantly different in the two groups (p = 0.815). However, there were more outliers in the CON side (8) than in the ROBOT side (1) (p = 0.013). In the coronal alignment of the femoral component, the CON side (8) had more outliers than the ROBOT side (1) (p = 0.013) and the CON side (3) also had more outliers than the ROBOT side (0) in the sagittal alignment of the femoral component (p = 0.043). In terms of outliers for coronal and sagittal tibial alignment, the CON side (1 and 4) had more outliers than the ROBOT side (0 and 2).

In this series robotic-assisted total knee replacement resulted in more accurate orientation and alignment of the components than that achieved by conventional total knee replacement.

Introduction: ROM after TKA can be influenced by multi-factors such as preoperative range of motion, body habitus, implant design, intraoperative surgical technique, and postoperative rehabilitation. Recently many implant manufacturers have made modifications to traditional total knee designs to improved maximal knee flexion and range of motion. Some posterior cruciate ligament (PCL) stabilized total knee prostheses that incorporate design features intended to improve knee kinematics in high flexion were introduced and the use of these prostheses has attracted attention. Recently in the cruciate retaining (CR) prosthesis, high-flexion knee (CR-Flex) and gender-specified prosthesis were designed to allow a greater and safer flexion after TKA. The aim of this study was to evaluate the effect of cruciate retaining typed different femoral component design on knee range of motion using a computerized navigation system.

Materials & method: 30 patients who underwent primary TKA because of primary osteoarthritis were included. EM navigation system was used in all cases. After tibia and femoral cutting using standard CR cutting block, standard fixed bearing CR knee (NexGen CR, Zimmer, Warsaw, IN) trial was inserted. If surgeon is satisfactory with alignment, stability and ligament balancing, the maximal knee extension and flexion was recorded using gravity by navigation system. Then, high-flexion fixed bearing CR knees(NexGen CR-Flex and Gender solution NexGen CR-Flex knee, Zimmer, Warsaw, IN) trial was inserted after additional posterior cutting. The maximal knee extension and flexion was evaluated exactly same way.

Results: Preoperative mean varus deformity was 10.52°. The mean flexion contracture was 7.52±6.81° and further flexion 129.9±7.94°. The average intraoperative maximal flexion of NexGen CR was 133.5±5.35° (125–146°) and that of hyper-flexion design were 135.5±5.77°(125–147°) in Nexgen CR-Flex and 136.1±5.76°(126–146°) in Gender knee. All knees showed greater than 125° of flexion regardless of the implant design. All knees can achieve physiologic leg alignment and nearly full extension of the knee after operation.

Conclusion: Hyper flexion designs showed subtle increase in mean maximal flexion and overall range of motion of the knee compared with the standard design, when it measured using navigation system intraoperatively. But clinically, it is not certain that these differences can lead to significant improvement of range of motion.

Cervical arthroplasty is usually performed for the treatment of soft disc herniation, but not for spondylotic radiculopathy. To our knowledge, there has no study to investigate the clinical and radiological results of cervical arthroplasty for spondylotic radiculopathy. We therefore performed the current study to evaluate clinical and radiological results of cervical arthroplasty for spondylotic radiculopathy with severe narrowing of the intervertebral disc space.

Eight patients, who underwent anterior decompression, overdistraction, and implantation of artificial cervical disc for primary, single-level spondylotic radiculopathy with severe narrowing of the disc space (decrease more than 50% of adjacent disc spaces) were included in this study. Four were male and 4 were female with mean age of 49.5 years. The operation level was 7 C5–6 and 1 C6–7. Five Prodisc-C and 3 Prestige LP prostheses were implanted. The clinical and radiological evaluations were performed with minimum one year follow-up (range, 12 – 19 months) after surgery.

VAS of the neck and arm pain improved (79.6 vs. 19.4 points, p < 0.01; 82.5 vs. 22.7 points, p < 0.01) at last follow-up, respectively. According to Odom’s criteria, satisfactory clinical outcome was achieved in 63% (5 out of 8, 3 excellent and 2 good) while fair result was achieved in 37% of the patients (3 out of 8). The disc space (3.0mm vs. 6.4mm, p < 0.01) and range of motion (1.4 vs. 6.3 degrees, p = 0.009) at the operated level increased, respectively. Overall sagittal alignment of the cervical spine was increased after surgery (5.2 vs. 11.3 degrees, p < 0.05). In 5 patients, segmental angle of the operated level was increased (0.2 vs. 5.3 degrees, p = 0.003) after surgery with maintained facet joint articulation overlap. However, in 3 patients, segmental angle of operated level became kyphotic from neutral (0 vs. −10.0 degrees, p = 0.295) with decreased facet joint articulation overlap.

In conclusions, cervical arthroplasty provided favorable clinical and radiological outcomes in most of the patients with spondylotic radiculopathy and severe narrowing of the disc space at minimum one year follow-up after surgery. However, in some of the patients, postoperative segmental kyphosis developed and clinical outcomes were not satisfactory.

The study is to evaluate mid-term follow-up clinical results and navigation prediction of the first 106 TKAs, which was performed based on the soft tissue balancing technique using the OrthoPilot navigation system (B.Braun Aesculap, Tuttlingen, Germany).

All the 106 cases were diagnosed as osteoarthritis with varus deformity. After anatomical and kinematic registration, the mechanical axis was restored to neutral (±2°) at full extension with step by step meticulous medial soft tissue release and osteophyte removal. Proximal tibial bone cutting was performed under real-time navigation system control. Flexion and extension gaps were measured at full extension and at 90° of flexion using a tensioning device (V-STAT tensor, Zimmer) and a special torque wrench set at 50lb/inch before femoral bone cutting. The flexion and extension gap was evaluated and it’s difference was classified into 3 kinds; balanced, tight flexion gap and tight extension gap. Sixty-one (57.5%) knees were classified as having a ‘balanced gap’ (meaning that flexion and extension gaps were within 2 mm), 20 (18.9%) knees as having a ‘tight flexion gap’ (an extension gap at least 3mm more that the corresponding flexion gap), and 25 (23.6%) knees as having a ‘tight extension gap’ (a flexion gap at least 3mm more that the corresponding extension gap). Depending extension/flexion, and medial/lateral gap difference, the level of distal femoral cut and the rotation of femoral component was determined. Following the final bone cuts and completion of soft tissue release, assessment of the flexion and extension gap was repeated. Balanced flexion and extension gap (difference between flexion and extension gap ≤ 3mm) was confirmed in 99 cases (94%). A mobile bearing prosthesis (e motion FP, B.Braun Aesculap) was used.

One patient (bilateral TKAs) died of unrelated causes at postoperative 2 year. One knee was revised due to infection. One hundred three cases were followed up at least more than 4 years, 53 months in average. Overall survival rate is 97%. Average preoperative HHS scores and range of motion (ROM) were 65.4 points (range, 33~82) and 126.8 degrees (80~140). At the last follow-up, HHS score and ROM were 95.0 points (78~100) and 131.4 degrees (110~140). Statistically significant improvement in HHS score and ROM were observed (p< 0.05). The mean mechanical axis was 179.44±1.83° (175~184°) with 8 cases of outliers (more than ±3° of optimum). There was no radiolucency, osteolysis, subsidence, or loosening at the last follow-up.

In conclusion, navigation is an excellent predictor for achieving balanced soft tissue & flexion-extension gap in primary total knee arthroplasty. Navigated TKAs using soft tissue balancing technique showed excellent clinical results and is effective methods achieving accurate mechanical axis and reducing prosthetic alignment outlier.