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Bone & Joint Open
Vol. 5, Issue 2 | Pages 79 - 86
1 Feb 2024
Sato R Hamada H Uemura K Takashima K Ando W Takao M Saito M Sugano N

Aims

This study aimed to investigate the incidence of ≥ 5 mm asymmetry in lower and whole leg lengths (LLs) in patients with unilateral osteoarthritis (OA) secondary to developmental dysplasia of the hip (DDH-OA) and primary hip osteoarthritis (PHOA), and the relationship between lower and whole LL asymmetries and femoral length asymmetry.

Methods

In total, 116 patients who underwent unilateral total hip arthroplasty were included in this study. Of these, 93 had DDH-OA and 23 had PHOA. Patients with DDH-OA were categorized into three groups: Crowe grade I, II/III, and IV. Anatomical femoral length, femoral length greater trochanter (GT), femoral length lesser trochanter (LT), tibial length, foot height, lower LL, and whole LL were evaluated using preoperative CT data of the whole leg in the supine position. Asymmetry was evaluated in the Crowe I, II/III, IV, and PHOA groups.


Bone & Joint Research
Vol. 12, Issue 9 | Pages 590 - 597
20 Sep 2023
Uemura K Otake Y Takashima K Hamada H Imagama T Takao M Sakai T Sato Y Okada S Sugano N

Aims

This study aimed to develop and validate a fully automated system that quantifies proximal femoral bone mineral density (BMD) from CT images.

Methods

The study analyzed 978 pairs of hip CT and dual-energy X-ray absorptiometry (DXA) measurements of the proximal femur (DXA-BMD) collected from three institutions. From the CT images, the femur and a calibration phantom were automatically segmented using previously trained deep-learning models. The Hounsfield units of each voxel were converted into density (mg/cm3). Then, a deep-learning model trained by manual landmark selection of 315 cases was developed to select the landmarks at the proximal femur to rotate the CT volume to the neutral position. Finally, the CT volume of the femur was projected onto the coronal plane, and the areal BMD of the proximal femur (CT-aBMD) was quantified. CT-aBMD correlated to DXA-BMD, and a receiver operating characteristic (ROC) analysis quantified the accuracy in diagnosing osteoporosis.


The Bone & Joint Journal
Vol. 103-B, Issue 11 | Pages 1656 - 1661
1 Nov 2021
Iwasa M Ando W Uemura K Hamada H Takao M Sugano N

Aims

Pelvic incidence (PI) is considered an important anatomical parameter for determining the sagittal balance of the spine. The contribution of an abnormal PI to hip osteoarthritis (OA) remains controversial. In this study, we aimed to investigate the relationship between PI and hip OA, and the difference in PI between hip OA without anatomical abnormalities (primary OA) and hip OA with developmental dysplasia of the hip (DDH-OA).

Methods

In this study, 100 patients each of primary OA, DDH-OA, and control subjects with no history of hip disease were included. CT images were used to measure PI, sagittal femoral head coverage, α angle, and acetabular anteversion. PI was also subdivided into three categories: high PI (larger than 64.0°), medium PI (42.0° to 64.0°), and low PI (less than 42.0°). The anterior centre edge angles, posterior centre edge angles, and total sagittal femoral head coverage were measured. The correlations between PI and sagittal femoral head coverage, α angle, and acetabular anteversion were examined.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 45 - 45
1 Nov 2021
Sugano N Hamada H Takao M Ando W Uemura K Nakamura N
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The purposes of this study were to evaluate the accuracy and feasibility of a robotic preparation for acetabular metal augments in patients with developmental dysplasia of the hip (DDH). Mako robotic arm reaming was used in 7 DDH to prepare the bony cavities for both Trident PSL cups and Tritanium acetabular wedge augments in six hips with Crowe 2 or 3 DDH. In CT-based planning, a properly sized cup was placed in the original acetabulum, and the same sized cup was also placed to fit the superolateral acetabular defect. The coordinates of the planned positions of cup and augment were recorded to manage the robotic arm reaming. After registration of the patient's pelvis, robotic reaming was performed first for the augment, then, for the cup by changing the target position of reaming as planned. The accuracy of the cup and augment placement was assessed on postoperative CT. To evaluate the feasibility of the robotic procedure, the OR time and blood loss were compared with those of 13 patients who received the same cup and augment systems with a conventional technique. All procedures were done without fracture or fixation failure. There were no differences in OR time or blood loss between the two procedures. Postoperative CT measurements of the distance between the cup center and the augment sphere center showed less than 2mm difference from the Mako preoperative planning.

Although a longer time of follow up evaluation is mandatory, our robotic acetabular augment preparation technique is accurate and feasible.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 6 - 6
1 Feb 2020
Ando W Hamada H Takao M Sugano N
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Introduction

Acetabular revision surgery is challenging due to severe bone defects. Burch-Schneider anti-protrusion cages (BS cage: Zimmer-Biomet) is one of the options for acetabular revision, however higher dislocation rate was reported. A computed tomography (CT)-based navigation system indicates us the planned direction for implantation of a cemented acetabular cup during surgery. A large diameter femoral head is also expected to reduce the dislocation rate. The purpose of this study is to investigate short-term results of BS cage in acetabular revision surgery combined with the CT-based navigation system and the use of large diameter femoral head.

Methods

Sixteen hips of fifteen patients who underwent revision THA using allografts and BS cage between September 2013 and December 2017 were included in this study with the follow-up of 2.7 (0.1–5.0) years. There were 12 women and three men with a mean age of 78.6 years (range, 59–61 years). The cause of acetabular revision was aseptic loosening in all hips.

The failed acetabular cup was carefully removed, and acetabular bone defect was graded using the Paprosky classification. Structural allografts were morselized and packed for all medial or contained defects. In some cases, solid allograft was implanted for segmental defects. BS cage was molded to optimize stability and congruity to the acetabulum and fixed with 6.5 mm titanium screws to the iliac bone. The inferior flange was slotted into the ischium. The upside-down trial cup was attached to a straight handle cup positioner with instrumental tracker (Figure 1) and placed on the rim of the BS cage to confirm the direction of the target angle for cement cup implantation under the CT-based navigation system (Stryker). After removing the cement spacer around the X3 RimFit cup (Stryker) onto the BS cage for available maximum large femoral head, the cement cup was implanted with confirming the direction of targeting angle.

Japanese Orthopedic Association score (JOA score) of the hip was used for clinical assessment. Implant position, loosening, and consolidation of allograft were assessed using anterior and lateral radiographies of the pelvis.


Introduction

Robotic-assisted hip arthroplasty helps acetabular preparation and implantation with the assistance of a robotic arm. A computed tomography (CT)-based navigation system is also helpful for acetabular preparation and implantation, however, there is no report to compare these methods. The purpose of this study is to compare the acetabular cup position between the assistance of the robotic arm and the CT-based navigation system in total hip arthroplasty for patients with osteoarthritis secondary to developmental dysplasia of the hip.

Methods

We studied 31 hips of 28 patients who underwent the robotic-assisted hip arthroplasty (MAKO group) between August 2018 and March 2019 and 119 hips of 112 patients who received THA under CT-based navigation (CT-navi group) between September 2015 and November 2018. The preoperative diagnosis of all patients was osteoarthritis secondary to developmental dysplasia of the hip. They received the same cementless cup (Trident, Stryker). Robotic-assisted hip arthroplasty were performed by four surgeons while THA under CT-based navigation were performed by single senior surgeon. Target angle was 40 degree of radiological cup inclination (RI) and 15 degree of radiological cup anteversion (RA) in all patients. Propensity score matching was used to match the patients by gender, age, weight, height, BMI, and surgical approach in the two groups and 30 patients in each group were included in this study. Postoperative cup position was assessed using postoperative anterior-posterior pelvic radiograph by the Lewinnek's methods. The differences between target and postoperative cup position were investigated.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 130 - 130
1 Apr 2019
Tamura K Takao M Hamada H Sakai T Sugano N
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Introduction

Most of patients with unilateral hip disease shows muscle volume atrophy of pelvis and thigh in the affected side because of pain and disuse, resulting in reduced muscle weakness and limping. However, it is unclear how the muscle atrophy correlated with muscle strength in the patient with hip disorders. A previous study have demonstrated that the volume of the gluteus medius correlated with the muscle strength by volumetric measurement using 3 dimensional computed tomography (3D-CT) data, however, muscles influence each other during motions and there is no reports focusing on the relationship between some major muscles of pelvis and thigh including gluteus maximus, gluteus medius, iliopsoas and quadriceps and muscle strength in several hip and knee motions. Therefore, the purpose of the present study is to evaluate the relationship between muscle volumetric atrophy of major muscles of pelvis and thigh and muscle strength in flexion, extension and abduction of hip joints and extension of knee joint before surgery in patients with unilateral hip disease.

Material and Methods

The subjects were 38 patients with unilateral hip osteoarthritis, who underwent hip joint surgery. They all underwent preoperative computed tomography (CT) for preoperative planning. There were 6 males and 32 females with average age 59.5 years old.

Before surgery, isometric muscle strength in hip flexion, hip extension, hip abduction and knee extension were measured using a hand held dynamometer (µTas F-1, ANIMA Japan).

Major muscles including gluteus maximus, gluteus medius, iliopsoas and quadriceps were automatically extracted from the preoperative CT using convolutional neural networks (CNN) and were corrected manually by the experienced surgeon.

The muscle volumetric atrophy ratio was defined as the ratio of muscle volume of the affected side to that of the unaffected side. The muscle weakness ratio was defined as the ratio of muscle strength of the affected side to that of the unaffected side.

The correlation coefficient between the muscle atrophy ratio and the muscle weakness ratio of each muscle were calculated.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 75 - 75
1 Apr 2019
Boughton O Uemura K Tamura K Takao M Hamada H Cobb J Sugano N
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Objectives

For patients with Developmental Dysplasia of the Hip (DDH) who progress to needing total joint arthroplasty it is important to understand the morphology of the femur when planning for and undertaking the surgery, as the surgery is often technically more challenging in patients with DDH on both the femoral and acetabular parts of the procedure1. The largest number of male DDH patients with degenerative joint disease previously assessed in a morphological study was 122. In this computed tomography (CT) based morphological study we aimed to assess whether there were any differences in femoral morphology between male and female patients with developmental dysplasia undergoing total hip arthroplasty (THA) in a cohort of 49 male patients, matched to 49 female patients.

Methods

This was a retrospective study of the pre-operative CT scans of all male patients with DDH who underwent THA at two hospitals in Japan between 2006–2017. Propensity score matching was used to match these patients with female patients in our database who had undergone THA during the same period, resulting in 49 male and 49 female patients being matched on age and Crowe classification. The femoral length, anteversion, neck-shaft angle, offset, canal-calcar ratio, canal flare index, lateral centre-edge angle, alpha angle and pelvic incidence were measured for each patient on their pre-operative CT scans.


The Bone & Joint Journal
Vol. 101-B, Issue 3 | Pages 297 - 302
1 Mar 2019
Tamura K Takao M Hamada H Ando W Sakai T Sugano N

Aims

The aim of this study was to examine whether hips with unilateral osteoarthritis (OA) secondary to developmental dysplasia of the hip (DDH) have significant asymmetry in femoral length, and to determine potential related factors.

Patients and Methods

We enrolled 90 patients (82 female, eight male) with DDH showing unilateral OA changes, and 43 healthy volunteers (26 female, 17 male) as controls. The mean age was 61.8 years (39 to 93) for the DDH groups, and 71.2 years (57 to 84) for the control group. Using a CT-based coordinate measurement system, we evaluated the following vertical distances: top of the greater trochanter to the knee centre (femoral length GT), most medial prominence of the lesser trochanter to the knee centre (femoral length LT), and top of the greater trochanter to the medial prominence of the lesser trochanter (intertrochanteric distance), along with assessments of femoral neck anteversion and neck shaft angle.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 57 - 57
1 Jan 2018
Sugano N Hamada H Takao M Sakai T Nakamura N
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The purposes of this study were to review retrospectively the 10-year outcome of cementless total hip arthroplasty (THA) using an active robot system in the femoral canal preparation for an anatomic short stem and navigation in the cup placement through a mini incision posterior approach. We reviewed all patients who underwent THA with this procedure in 53 hips between 2004 and 2007. There were no intraoperative fracture nor navigation- or robotic-related complications. All implant sizes were same as planned ones. All cases were followed up at least two years and all implants showed bone ingrowth stable according to the Engh's criteria. After then, six patients died of unrelated causes. Two patients (three hips) could not come to the 10-year follow-up examination. The remaining 44 hips were followed for 10 to 12 years (11 years on average). There is no dislocation. The average JOA hip score improved from 48 preoperatively to 96 at the final examination. On the postoperative x-ray measurements, the average cup radiographic inclination was 39° and the radiographic anteversion was 14°. There was no stem which showed more than 2° of varus or valgus alignment. There was no case who showed more than 5mm of limb length discrepancy. Postoperative CT images of 38 hips were obtained at 2 weeks. After matching the coordinates of the pelvis and femur with the preoperative planning, we got very small differences in alignment parameters between the measured values and the planed ones. The difference differences between the plan and measured values were −0.1° in cup inclination, −1.4° in cup anteversion, stem 0.5° in coronal alignment, 0.6° in stem sagittal alignment, and −1.6° in stem anteversion, respectively. We conclude that our robotic femoral preparation for a short anatomical stem and navigated cup placement thru a mini-posterior approach was safe and feasible without affecting the accuracy of the procedure. There were no long term adverse effect of the procedure.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_20 | Pages 23 - 23
1 Dec 2017
Sakai T Hamada H Murase T Takao M Yoshikawa H Sugano N
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The purpose of this experimental study was to elucidate the accuracy of neck-cut PSG setting, and femoral component implantation using neck-cut PSG in the THA through the anterolateral-approach relative to the preoperative planning goals, and to determine the usefulness of PSG compared with the procedure without PSG. A total of 32 hips from 16 fresh Caucasian cadaveric samples were used and classified into 4 groups: cementless anatomical stem implantation with wide-base-contact PSG (AWP: 8 hips, Fig.2); (2) cementless anatomical stem implantation with narrow-base-contact PSG (ANP: 8 hips, Fig.2); (3) cementless anatomical stem implantation without PSG (Control: 8 hips); and (4) cementless taper-wedge stem implantation with wide-base-contact PSG (TWP: 8 hips). The absolute error of PSG setting in the sagittal plane of the AWP group was significantly less than that of the ANP (p=0.003).THA with wide-base- contact PSG resulted in better alignment of the femoral component than THA without PSG or with narrow- base-contact PSG. Although the neck-cut PSG did not control the sagittal alignment of taper-wedge stem, the neck-cut PSG was effective to realise the preoperative coronal alignment and medial height for THA via the anterolateral approach regardless of the femoral component type.

For figures and tables, please contact authors directly.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 56 - 56
1 Mar 2017
Uemura K Takao M Otake Y Koyama K Yokota F Hamada H Sakai T Sato Y Sugano N
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Background

Cup anteversion and inclination are important to avoid implant impingement and dislocation in total hip arthroplasty (THA). However, it is well known that functional cup anteversion and cup inclination also change as the pelvic sagittal inclination (PSI) changes, and many reports have been made to investigate the PSI in supine and standing positions. However, the maximum numbers of subjects studied are around 150 due to the requirement of considerable manual input in measuring the PSIs. Therefore, PSI in supine and standing positions were measured fully automatically with a computational method in a large cohort, and the factors which relate to the PSI change from supine to standing were analyzed in this study.

Methods

A total of 422 patients who underwent THA from 2011 to 2015 were the subjects of this study. There were 83 patients with primary OA, 274 patients with DDH derived secondary OA (DDH-OA), 48 patients with osteonecrosis, and 17 patients with rapidly destructive coxopathy (RDC). The median age of the patient was 61 (range; 15–87). Preoperative PSI in supine and standing positions were measured and the number of cases in which PSI changed more than 10° posteriorly were calculated. PSI in supine was measured as the angle between the anterior pelvic plane (APP) and the horizontal line of the body on the sagittal plane of APP, and PSI in standing was measured as the angle between the APP and the line perpendicular to the horizontal surface on the sagittal plane of APP (Fig. 1). The value was set positive if the pelvis was tilted anteriorly and was set negative if the pelvis tilted posteriorly. Type of hip disease, sex, and age were analyzed with multiple logistic regression analysis if they were related to PSI change of more than 10°. For accuracy verification, PSI in supine and standing were measured manually with the previous manual method in 100 cases and were compared with the automated system used in this study.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 39 - 39
1 Mar 2017
Takao M Ogawa T Yokota F Otake Y Hamada H Sakai T Sato Y Sugano N
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Introduction

Patients with hip osteoarthritis have a substantial loss of muscular strength in the affected limb compared to the healthy limb preoperatively, but there is very little quantitative information available on preoperative muscle atrophy and degeneration and their influence on postoperative quality of life (QOL) and the risk of falls. The purpose of the present study were two folds; to assess muscle atrophy and degeneration of pelvis and thigh of patients with unilateral hip osteoarthritis using computed tomography (CT) and to evaluate their impacts on postoperative QOL and the risk of falls.

Methods

We used preoperative CT data of 20 patients who underwent primary total hip arthroplasty. The following 17 muscles were segmented with our developed semi-automated segmentation method: iliacus, gluteus maximus, gluteus medius, gluteus minimus, rectus femoris, tensor facia lata, adductors, pectinus, piriformis, obturator externus, obturator internus, semimenbranosus, semitendinosus, vastus medialis and vastus lateralis/intermedius (Fig. 1). Volume and radiological density of each muscle were measured. The ratio of those of affected limb to healthy limb was calculated. At the latest follow-up, the WOMAC score was collected and a history of falls after surgery was asked. The average follow- up period was 6 years.

Comparison of the volume and radiological density of each muscle between affected and healthy limbs was performed using the Wilcoxon signed rank test. Correlations between the volume and radiological density of each muscle and each score of the WOMAC were evaluated with Spearman's correlation coefficient. The volume and radiological density of each muscle between patients with and without a history of falls were compared using Mann-Whitney U test.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 23 - 23
1 Mar 2017
Sugano N Nakahara I Hamada H Takao M Sakai T Ohzono K
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The purposes of this study were to review retrospectively the 25-year survival of cemented and cementless THA for hip dysplasia and to compare the effect of fixation methods on the long-term survival in patients with DDH. We retrospectively reviewed all patients with OA secondary to hip dysplasia treated with a cemented Bioceram hip system between 1981 and 1987, and a cementless cancellous metal Lübeck hip system between 1987 and 1991. The studied subjects were 76 hips of cemented THA (Group-C) and 57 hips of cementless THA (Group-UC). Both hip implants had a 28-mm alumina head on polyethylene articulation. The mean age at operation was 50.5 years (range, 36–60 years) in Group-C and 50.0 years (range, 29–60 years) in Group-UC. The survival at 25 years regarding any revision as the endpoint was 46% in Group-C and 76% in Group-UC. These difference was significant using Log-rank test (P=0.008). The cup survival at 25 years was 47% in Group-C and 83% in Group-UC (P= 0.0003). The stem survivals at 25 years were 95% in Group-C and 92% in Group-UC. (P= 0.416). Cementless THA in patients with DDH showed a higher survival rate at 25 years than cemented THA because of the excellent survival of the acetabular component without cement. We conclude that cementless THA with the cancellous metal Lübeck hip system led to better longevity at 25 years than cemented THA with the Bioceram in patients with OA secondary to DDH.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 24 - 24
1 Mar 2017
Sugano N Uemura K Ogawa T Hamada H Takao M Sakai T
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Although many distal fit and fill design cementless stems have shown a very good long term stable fixation, short proximal coated stems are recently increasing in their use with an expectation of less stress shielding and an ease of removal at revision surgery. We introduced an anatomic short stem made from titanium alloy with proximal plasma-spray titanium and hydroxyapatite coating (CentPillar, Stryker, Mahwah) in 2002. To evaluate a minimum 10-year outcome of the system in terms of fixation and stress shielding, we reviewed initial 100 consecutive cases operated by a single surgeon. There were 91 hips with osteoarthritis and 9 hips with osteonecrosis. There were 94 females and 6 males. Average age at operation was 58 years. The patients were followed up for an average of 11 years. Average JOA hip score improved significantly from 46.9 preoperatively to 96.7 at the final examination. There were no dislocation, or revision, or radiographic loosening. When we looked at the level of bone atrophy, 80% of cases showed no stress shielding below the lessor trochanter. We conclude that the CentPillar stem showed mild stress shielding due to short proximal bone ongrowth coating while keeping a long term good clinical score and radiographic stability.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_5 | Pages 132 - 132
1 Mar 2017
Sakai T Koyanagi J Takao M Hamada H Sugano N Yoshikawa H Sugamoto K
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INTRODUCTION

The purpose of this study is to elucidate longitudinal kinematic changes of the hip joint during heels-down squatting after THA.

METHODS

66 patients with 76 primary cementless THAs using a CT-based navigation system were investigated using fluoroscopy. An acetabular component and an anatomical femoral component were used through the mini-posterior approach with repair of the short rotators. The femoral head size was 28mm (9 hips), 32mm (12 hips), 36mm (42 hips), and 40mm (12 hips). Longitudinal evaluation was performed at 3 months, 1 year, and 2≤ years postoperatively. Successive hip motion during heels-down squatting was recorded as serial digital radiographic images in a DICOM format using a flat panel detector. The coordinate system of the acetabular and femoral components based on the neutral standing position was defined. The images of the hip joint were matched to 3D-CAD models of the components using a2D/3D registration technique. In this system, the root mean square errors of rotation was less than 1.3°, and that of translation was less than 2.3 mm. We estimated changes in the relative angle of the femoral component to the acetabular component, which represented the hip ROM, and investigated the incidence of bony and/or prosthetic impingement during squatting (Fig.1). We also estimated changes in the pelvic posterior tilting angle (PA) using the acetabular component position change. In addition, when both components were positioned most closely during squatting, we estimated the minimum angle (MA) up to theoretical prosthetic impingement as the safety margin (Fig.2).


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_5 | Pages 62 - 62
1 Mar 2017
Ogawa T Miki H Hattori A Hamada H Takao M Sakai T Suzuki N Sugano N
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Introduction

Range of motion (ROM) simulation of the hip is useful to understand the maximum impingement free ROM in total hip arthroplasty (THA). In spite of a complex multi-directional movement of the hip in daily life, most of the previous reports have evaluated the ROM only in specific directions such as flexion-extension, abduction-adduction, and internal - external rotation at 0° or 90° of hip flexion. Therefore, we developed ROM simulation software (THA analyzer) to measure impingement free ROM in any positions of the hip. Recent designs of the hip implants give a wider ROM by increasing the head diameter and then, bone to bone impingement can be a ROM limit factor particularly in a combination of deep flexion, adduction and internal rotation of the hip. Therefore, the purpose of this study were to observe an individual variation in the pattern of the bone impingement ROM in normal hip bone models using this software, to classify the bone impingement ROM mapping types and to clarify the factors affecting the bone impingement type.

Methods

The subjects were 15 normal hips of 15 patients. Three dimensional surface models of the pelvis and femur were reconstructed from Computer tomography (CT) images. We performed virtual hip implantation with the same center of rotation, femoral offset, and leg length as the original hips. Subsequently, we created the ROM mapping until bone impingement using THA analyzer. We measured the following factors influenced on the bone impingement map patterns; the neck shaft angle, the femoral offset, femoral anteversion, pelvic tilt, acetabular anteversion, sharp angle, and CE angle. These factors were compared between the two groups. Statistical analysis was performed with Mann-Whitney U test, and statistical significance was set at P<0.05.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_10 | Pages 97 - 97
1 May 2016
Uemura K Takao M Sakai T Nishii T Sugano N
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Introduction

In total hip arthroplasty (THA), it is important to define the coordinate system of the pelvis and femur for standardization in measuring the implant alignment. A coronal plane of the pelvis (functional pelvic coordinates) in supine position has been recommended as the pelvic coordinates for cup orientation and an anatomical plane of the femur (posterior condylar plane: PCP) is widely used as the femoral coordinates to measure stem or femoral anteversion. It has been reported that the pelvic sagittal tilt in supine does not change a lot after THA. However, changes in the axial rotation of the posterior condylar plane after THA have not been well studied. If the horizontal tilt of PCP of the femur in a resting position changes a lot after THA, the combined anteversion theory cannot be functional. Therefore, we evaluated the angulation changes of the posterior condylar plane after THA and analyzed the related factors by using CT images.

Methods

Forty patients (5 men and 35 women, mean age 58 years) with hip osteoarthritis who had undergone THA were the subjects of this study. CT images used for measurements were taken preoperatively (preop-CT) and 3 weeks after THA (postop-CT), and more than 2 years after THA (2nd postop-CT).

Measurements were done on the reconstructed CT images using 3D viewer software. The axial rotation of the femur was measured as the angle between the posterior condylar line (PCL) and a line through the bilateral anterior superior iliac spines. To analyze the factors relating to the rotational change of the femur, change in femoral anteversion, leg length, and leg medialization after THA were also measured. Surgical approach (posterolateral: 32 cases, direct anterior: 8 cases) was also evaluated as a factor relating to the rotational change.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_10 | Pages 56 - 56
1 May 2016
Sugano N Takao M Sakai T Nishii T Ohzono K
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Introduction

Metal on metal hip resurfacing (MoM HR) is attractive for young active patients. Patients with osteonecrosis of the femoral head (ONFH) are relatively young. HR can be an option of treatment, however, long-term stability of the femoral component is a concern because of the necrotic lesion in the femoral head. There is also a concern of ARMD for MoM implants. The purpose of this study is review a 10 year outcome of a consecutive patients with ONFH who underwent MoM HR.

Methods

The subjects of this study were 30 hips of 26 patients with ONFH who underwent HR between 1998 and 2004. There were 21 hips of 18 males and 9 hips of 8 females. The average age at operation was 40 years (range, 20–63 years). 19 ONFHs were induced by steroid and 11 ONFHs were alcohol related. According to the Japanese Investigation Committee classification, there were 8 hips with Type C1 and 22 hips with Type C2. There were 16 hips in stage 3A, 7 hips in Stage 3B, and 7 hips in Stage 4. Operation was performed through a posterior approach. A fragile necrotic bone was curettage thoroughly and the defect was filled with cement.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_9 | Pages 94 - 94
1 May 2016
Ogawa T Takao M Sakai T Nishii T Sugano N
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Introduction

The incidence of dislocation after total hip arthroplasty (THA) was reported to be 0.5 to 10% in primary THA and 10 to 25 % in revision THA. The main causes of instability after THA were reported to be implant malalignment and inappropriate soft tissue tension. However, there was no study about quantitative data of soft tissue tension of unstable THA. The purpose of this study is to clarify the features of soft tissue tension of unstable THA in comparison to stable THA.

Methods

The subjects were 15 patients with 15 THAs who had developed recurrent dislocation after primary THA. Thirty four patients with 37 THAs who developed no dislocation for one year after surgery were recruited as a stable THA group. In both group, all THAs were performed through posterolateral approach. In order to assess the soft tissue tension of THA, we recorded antero-posterior radiographs of the hips while applying distal traction to the leg with traction forces of 20?, 30%, 40% of body weight (BW). The distance of separation of the head and the cup after traction was measured under correction of magnification. Nine of 15 THAs in the unstable THA group and 32 of 37 THAs in the stable THA group were unilateral involvement. In the hips with unilateral involvement, the femoral offset difference between the healthy hip and the reconstructed hip were evaluated. Statistical analysis was performed with χ2 testand Mann-Whitney U test, and statistical significance was set at P<0.05.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_5 | Pages 37 - 37
1 Feb 2016
Hamada H Takao M Uemura K Sakai T Nishii T Sugano N
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Rotational acetabular osteotomy (RAO) for developmental dysplasia of the hip (DDH) may not restore normal hip range of motion (ROM) due to the inherent deformity of the hip and it may lead to femoro-acetabular impingement. The purpose of this study was to investigate morphological factors of the pelvis and femur influencing on simulated ROM after RAO with a fixed target for femoral head coverage. We retrospectively reviewed CT images of 52 DDHs with an average lateral centre edge angle (CEA) of 7.9° (−12° to 19°). After virtual RAO with 30° of lateral CEA and 55° of anterior CEA producing femoral head coverage similar to that of the normal hips, we measured simulated flexion ROM using pelvic and femoral computer models reconstructed from the CT images. Pelvic sagittal inclination, acetabular anteversion, lateral CEA, femoral neck anteversion, femoral neck shaft angle (FNSA), alpha angle and the position of the anterior inferior iliac spine (AIIS) were investigated as morphological factor. When the most prominent point of the AIIS existed more distally than the cranial tip of the acetabular joint line in a lateral view of the pelvis model in supine position, the subjects were defined as AIIS-Type1; the remaining subjects were defined as Type 2. There were 10 hips with Type 1 and 42 hips with Type 2 AIIS. The Kappa value of inter-observer reproducibility to classify AIIS was 0.82. Multiple regression analyses were performed to analyse the relationship between ROM and the morphological parameters. We also analysed the relationship between the probability of flexion ROM being less than 110° and the factors which influenced on flexion ROM. FNSA and AIIS-Type independently influenced on simulated flexion ROM after RAO (standard regression coefficient: −0.51 and 0.37, respectively. p&lt; 0.001). The multiple correlation coefficient was 0.68. Flexion ROM after RAO with a fixed femoral head coverage similar to that of the normal hips ranged from 95° to 141° with an average of 121°±8°. The probability of ROM being less than 110° was significantly higher in subjects with AIIS-Type 1 than in those with Type 2 (odds ratio: 13.3, p&lt;0.01). It was also significantly higher in subjects with more than 135° of FNSA than in those with less than 135° of FNSA (odds ratio: 9.5, p&lt;0.05). FNSA and the type of AIIS influenced on flexion ROM after RAO with approximately 40° of variation in spite of a fixed target for femoral head coverage. A large FNSA and a distal positioning of AIIS were independently associated with smaller flexion ROM after RAO.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_5 | Pages 48 - 48
1 Feb 2016
Takao M Nishii T Sakai T Yoshikawa H Sugano N
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Introduction

Inappropriate soft tissue tension around an artificial hip is regarded as one cause of dislocation or abductor muscle weakness. It has been considered that restoration of leg offset is important to optimise soft tissue tension in THA, while it is unclear what factors determine soft tissue tension around artificial hip joints. The purpose of the present study was to assess how postoperative leg offset influence the soft tissue tension around artificial hip joints.

Materials and Methods

The subjects were 89 consecutive patients who underwent mini-incision THA using a navigation system through antero-lateral or postero-lateral approach. Soft tissue tension was measured by applying traction amounting to 40% of body weight with the joint positioned at 0°, 15°, 30°, and 45° of flexion. The distance of separation between the head and the cup was measured using the navigation system.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_3 | Pages 97 - 97
1 Jan 2016
Ogawa T Takao M Sakai T Nishii T Sugano N
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Puropose

Three-dimensional (3D) templating based on computed tomography (CT) in total hip arthroplasty improves the accuracy of implant size. However, even when using 3D-CT preoperative planning, getting the concordance rate between planned and actual sizes to reach 100% is not easy. To increase the concordance rate, it is important to analyze the causes of mismatch; however, no such studies have been reported. This study had the following two purposes: to clarify the concordance rate in implant size between 3D-CT preoperative planning and actual size; and to analyze risk factors for mismatch.

Materials and Methods

A single surgeon performed 149 THAs using Trident Cup and Centpillar Stem (Stryker) with CT-based navigation between September 2008 and August 2011. Minimal follow-up was 2 years. Patients with incomplete postoperative CT were excluded from this study. Based on these criteria, the study examined 124 hips in 111 patients (mean age, 60 years, mean BMI 23.2 kg/m2). The preoperative diagnosis was primary osteoarthritis in 8 hips, secondary osteoarthritis in 102 hips, osteonecrosis in 9 hips, rapidly destructive coxopathy in 4 hips and rheumatoid arthritis in 1 hip. We compared cup and stem sizes between preoperative planning and intraoperatively used components. Radiological evaluations were cortical index and canal flare index on preoperative X-rays. We evaluated preoperative planning and postoperative components for cup orientation, cup position, and stem alignment (anteversion, flexion and varus angle) on the CT-navigation system. Fixation of the stem was evaluated by X-ray radiography at 2 years postoperatively according to Engh's criteria. Statistical analysis was performed with the Mann-Whitney U test, and values of P<0.05 were considered statistically significant.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 47 - 47
1 Jan 2016
Takao M Nishii T Sakai T Sugano N
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In total hip arthroplasty (THA), inappropriate cup alignment cause edge loading and prosthetic impingement, which lead to various mechanical problems including dislocation, excessive wear and breakage of bearing materials, and stem neck fracture. To find the optimal cup alignment, various computer simulation studies have been conducted. However there have been few studies focusing on pelvic coordinate system as a reference of cup positioning. Our hypothesis is that the functional pelvic coordinate system with pelvic sagittal inclination in the supine position is appropriate for a reference frame of cup alignment. To test the hypothesis, we have been investigating preoperative and postoperative kinematics of pelvis and hip of THA patients.

In 25 % of the consecutive 163 patients, the difference in preoperative pelvic inclination angle between the supine and standing positions (positional change of pelvic inclination [PC]) was 10o or more. Patients’ age and age-related spinal disorders including compression fracture and lumbar spondylolisthesis were independent factors associated with large preoperative PC. This raises a concern that large PC might increase the risk of edge loading and posterior prosthetic impingement when cup was positioned referencing supine pelvic position, especially in elderly patients.

We compared kinematics of the hip after THA in patients with a preoperative large PC (≥10°) with that in patients with a preoperative small PC (<10°), assuming that the supine position as a zero position of the pelvis. First, we compared intraoperative passive range of motion (ROM) after implantation of the 91 hips using navigation system. No significant differences in intraoperative hip ROM were observed between the both groups. Next, we compared postoperative ROM of the 50 hips during motion of daily livings using our 4-dimentional motion analysis system within two year after THA. No significant differences in postoperative hip flexion or extension angles were observed between the both groups. These results suggested that if cup was positioned referencing the supine pelvic position, the degree of preoperative PC does not matter early after primary THA.

Regarding long-term change of pelvic inclination after THA, 49 % of 70 patients followed for 10 years showed the change more than 10o in the standing position, although only 9% showed the change more than 10o in the supine position. This means that aging after THA increase discrepancy of pelvic inclination between the preoperative supine position as the reference for preoperative planning and the postoperative standing positions in some patients. However we could not find any preoperative predictors of this long-term change of pelvic inclination in the standing position. Therefore, although it is unclear whether surgeons should change the reference pelvic plane for cup alignment taking the longitudinal change of pelvic inclination in the standing position, at least, strict cup alignment control at primary THA is considered to be important to minimize the risk of edge loading and prosthetic impingement due to longitudinal changes of pelvic inclination.

In conclusion, our current recommendation of pelvic coordinate system as a reference of cup alignment is a functional pelvic coordinate system with pelvic sagittal inclination in supine position.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 84 - 84
1 Jan 2016
Uemura K Takao M Sakai T Nishii T Sugano N
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Introduction

Support cages are often used for reconstruction of acetabular bone defects in revision total hip arthroplasty. A Burch-Schneider cage is one of the most reliable systems that has shown good clinical results. It has an ischial flange and an iliac plate for screw fixation to the ilium. It is sometimes necessary to bend the flange or the plate to fit the shape of the peri-acetabulum. However, the frequency, indications, and characteristics of bending the flange or plate have not been reported. To clarify them, a simulation study was conducted.

Materials and methods

Twenty-five cases with acetabular bone defects of Paprosky type 2, 3, or 4 were the subjects of this study. A 3D template surgical simulation was conducted using 3D surface models of the Burch-Schneider cage and acetabulum. The size of the cage was determined by the size of the cavitary bone defect. Placement of the cage was performed in two ways. One was the iliac plate fitting method, in which fitting of the iliac plate to the ilium was performed first, followed by bending of the ischial flange to keep the flange in the center of the ischium. When bending of the flange was needed, it was bent at the base. The other method was the ischial flange fitting method, in which the ischial flange was inserted from the center of the ischium, followed by bending of the iliac flange to adapt to the ilium. When bending of the plate was needed, it was bent at the base. In both methods, the direction and angle of bending were measured.


The Bone & Joint Journal
Vol. 96-B, Issue 5 | Pages 580 - 589
1 May 2014
Nakahara I Takao M Sakai T Miki H Nishii T Sugano N

To confirm whether developmental dysplasia of the hip has a risk of hip impingement, we analysed maximum ranges of movement to the point of bony impingement, and impingement location using three-dimensional (3D) surface models of the pelvis and femur in combination with 3D morphology of the hip joint using computer-assisted methods. Results of computed tomography were examined for 52 hip joints with DDH and 73 normal healthy hip joints. DDH shows larger maximum extension (p = 0.001) and internal rotation at 90° flexion (p < 0.001). Similar maximum flexion (p = 0.835) and external rotation (p = 0.713) were observed between groups, while high rates of extra-articular impingement were noticed in these directions in DDH (p < 0.001). Smaller cranial acetabular anteversion (p = 0.048), centre-edge angles (p < 0.001), a circumferentially shallower acetabulum, larger femoral neck anteversion (p < 0.001), and larger alpha angle were identified in DDH. Risk of anterior impingement in retroverted DDH hips is similar to that in retroverted normal hips in excessive adduction but minimal in less adduction. These findings might be borne in mind when considering the possibility of extra-articular posterior impingement in DDH being a source of pain, particularly for patients with a highly anteverted femoral neck.

Cite this article: Bone Joint J 2014;96-B:580–9.


The Bone & Joint Journal
Vol. 95-B, Issue 10 | Pages 1320 - 1325
1 Oct 2013
Tamura S Nishii T Takao M Sakai T Yoshikawa H Sugano N

We investigated differences in the location and mode of labral tears between dysplastic hips and hips with femoroacetabular impingement (FAI). We also investigated the relationship between labral tear and adjacent cartilage damage. We retrospectively studied 72 symptomatic hips (in 68 patients: 19 men and 49 women) with radiological evidence of dysplasia or FAI on high-resolution CT arthrography. The incidence and location of labral tears and modes of tear associated with the base of the labrum (Mode 1) or body of the labrum (Mode 2) were compared among FAI, mildly dysplastic and severely dysplastic hips. The locations predominantly involved with labral tears were different in FAI and mild dysplastic hips (anterior and anterosuperior zones) and in severely dysplastic hips (anterosuperior and superior zones) around the acetabulum. Significant differences were observed in the prevalence of Mode 1 versus Mode 2 tears in FAI hips (72% (n = 13) vs 28% (n = 5)) and severe dysplastic hips (25% (n = 2) vs 75% (n = 6)). The frequency of cartilage damage adjacent to Mode 1 tears was significantly higher (42% (n = 14)) than that adjacent to Mode 2 tears (14% (n = 3)).

Hip pathology is significantly related to the locations and modes of labral tears. Mode 1 tears may be a risk factor for the development of adjacent acetabular cartilage damage.

Cite this article: Bone Joint J 2013;95-B:1320–5.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_16 | Pages 36 - 36
1 Apr 2013
Matsui K Miyamoto W Tsuchida Y Takao M Matsushita T
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Background

Growing of the geriatric population has brought about increase of lower extremity fractures. The purpose of this study was to investigate the occurrence of surgical site infection after the surgery for lower extremity fractures, except proximal femoral fracture, in over eighty years old patients.

Methods

Patients with closed lower extremity fracture which were treated surgically in 2011 were divided into two groups (Group O; the equal or more than 80 years old, Group Y; from 20 to 65 years old), and the incidence of infection and the outcome after its treatment was compared between Group O and Group Y.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 343 - 343
1 Mar 2013
Sugano N Takao M Sakai T Nishii T Nakahara I Miki H
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Although there are several reports of excellent long-term survival after cemented total hip arthroplasty (THA), cemented acetabular components are prone to become loose when compared with femoral components. On the other hand, the survival of cementless acetabular components has been reported to be equal or better than cemented ones and the use of cementless acetabular components is increasing. However, most of the reports on survival after THA are for patients with primary hip osteoarthritis (OA) and there is no report of 20-year survival of cementless THA for patients with hip dysplasia. It is supposed to be more difficult to fix cementless acetabular components for OA secondary to hip dysplasia than primary OA. The purposes of this study were to review retrospectively the 20-year survival of cemented and cementless THA for hip dysplasia and to compare the effect of fixation methods on the long-term survival for patients with hip dysplasia. We retrospectively reviewed all patients with OA secondary to hip dysplasia treated with a cemented Bioceram hip system between 1981 and 1987, and a cementless cancellous metal Lübeck hip system between 1987 and 1991. We excluded patients aged more than 60 years, males, and Crowe 4 hips. The studied subjects were 70 hips of cemented THA (Group-C) and 57 hips of cementless THA (Group-UC). Both hip implants had a 28-mm alumina head on polyethylene articulation. The mean age at operation was 50.5 years (range, 36–60 years) in Group-C and 50.0 years (range, 29–60 years) in Group-UC. The mean BMI was 23.2 kg/m2 in Group-C (range, 17.3–29.3 kg/m2) and 22.9 kg/m2 in Group-UC (range, 18.8–28.0 kg/m2). There were no significant differences in age and BMI between the two groups. The average follow-up period was 18.0 years in Group-C and 18.4 years in Group-UC. In Group-C, revision was performed in 33 hips due to aseptic cup loosening (30 hips), stem loosening (one hip), and loosening of both components (two hips). In Group-UC, revision was performed in 10 hips due to stem fracture secondary to distal fixation (4 hips), cup loosening (three hips), polyethylene breakage (two hips), and extensive osteolysis around the stem (one hip). The survival at 20 years regarding any revision as the endpoint was 51% in Group-C and 84% in Group-UC. This difference was significant using Log-rank test (P=0.006). The cup survival at 20 years was 54% in Group-C and 92% in Group-UC. This difference was also significant (P = 0.0003). The stem survival at 20 years was 95% in Group-C and 92% in Group-UC. This difference was not significant (P = 0.4826). Cementless THA showed a higher survival rate at 20 years for hip dysplasia than cemented THA because of the excellent survival of the acetabular component without cement. We conclude that cementless THA with the cancellous metal Lübeck hip system led to better longevity at 20 years than cemented THA with the Bioceram for patients with OA secondary to hip dysplasia.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 121 - 121
1 Sep 2012
Nishii T Sakai T Takao M Yoshikawa H Sugano N
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Purpose

There are concerns of soft-tissue reactions such as metal hypersensitivity or pseudotumors for metal-on-metal (MoM) bearings in hip arthroplasty, however, such reactions around ceramic or polyethylene bearings are incompletely understood. The present study was conducted to examine the capabilities of ultrasound screening and to compare the prevalence of periarticular soft-tissue lesions among various types of bearings.

Methods

Ultrasound examinations were conducted in 163 hips (153 patients) with arthroplasty after mean a follow-up of 8.1 years (range, 1–22 years). This included 39 MoM hip resurfacings (M-HR) including 30 Birmingham hip resurfacings (BHR) and 9 ADEPT resurfacings; 36 MoM total hip arthroplasties (M-THA) with a large femoral head including 26 BHR and 10 ADEPT bearings; 21 ceramic-on-ceramic THAs (C-THA) of Biolox forte alumina bearings; 24 THAs with a conventional polyethylene liner (cPE-THA) including 19 Lubeck and 5 Omnifit systems; and 43 THAs with a highly cross-linked polyethylene liner (hxPE-THA) including 28 Crossfire and 15 Longevity liners. All procedures were performed in the lateral position through the posterior approach without trochanteric osteotomy. The M-HR group had a significantly higher frequency of male patients than the C-THA, cPE-THA, and hxPE-THA groups, and the patients in the M-HR group were younger than those in the other four groups. Ultrasound images were acquired as a still picture and in video format as the hip moved in flexion and rotation, and 4 qualitative classifications for periarticular soft-tissue reactions were determined as normal pattern, joint-expansion pattern (marked hypoechoic space between the anterior capsule and the anterior surface of the femoral component), cystic pattern (irregularly shaped hypoechoic lesions), and mass pattern (a large mass extending anterior to the femoral component). Magnetic resonance imaging (MRI) was subsequently performed in 45 hips with high-frequency encoding bandwidths. For the reliability of ultrasound screening, positive predictive value, negative predictive value, and the accuracy of the presence of abnormal patterns on ultrasound were calculated using the abnormal lesions on MRI as a reference.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 185 - 185
1 Sep 2012
Takao M Nishii T Sakai T Sugano N
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Introduction

Preoperative planning is an essential procedure for successful total hip arthroplasty. Many studies reported lower accuracy of two-dimensional analogue or digital templating for developmentally dysplastic hips (DDH). There have been few studies regarding the utility of three-dimensional (3D) templating for DDH. The aim of the present study is to assess the accuracy and reliability of 3D templating of cementless THA for hip dysplasia.

Methods

We used 86 sets of 3D-CT data of 84 patients who underwent consecutive cementless THA using an anatomical stem and a rim-enlarged cup. There were six men and 78 women with the mean age of 58 years. The diagnosis was developmental dysplasia in 70 hips and osteonecrosis in 14 hips and primary osteoarthritis in 2 hips. There were 53 hips in Crowe group I, 11 hips in Crowe group II and 6 hips in Crowe group III. Each operator performed 3D templating prior surgery using a planning workstation of CT-based navigation system. Planned-versus-achieved accuracy was evaluated. The templating results were categorized as either exact size or +/− 1 size of implanted size. To assess the intra- and inter-planner reliabilities, 3D templating was performed by two authors blinded to surgery twice at an interval of one month. Kappa values were calculated. The accuracy and the intra- and inter-planner reliabilities were compared between the DDH group (70 hips) and the non DDH group (16 hips).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 186 - 186
1 Sep 2012
Takao M Nishii T Sakai T Sugano N
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Introduction

The shuck test was widely used to assess the overall soft-tissue tension around the hip joint during surgery. There have been few attempts to standardize how one evaluates soft tissue tension in total hip arthroplasty. The aim of this study was to ask how reliable the shuck test was as a measure of soft tissue tension in total hip arthroplasty.

Methods

First, we assessed the intra- and inter-examiner variability of the force generated in the shuck test. Next, we asked how the strength of traction forces and joint position on the distance of displacement of the prosthetic head at surgery. Twenty-one hip surgeons, consisting of seven experienced hip surgeons, seven junior hip surgeons, and seven surgeons in training were included in the first study. Test subjects were instructed to pull a traction gauge with their customary range of force. Each subject performed two sets of the shuck test in one week interval. Eighteen patients who had cementless THA through postero-lateral approach using 3D-CT based navigation system were enrolled in the second study. After implantation of components, the leg was pull caudally using our original device [Fig. 1]. The strength of applied traction force was 20 %, 30 %, 40 % and 50 % of body weight of each patient. The distance of displacement of a prosthetic head during traction was recorded at flexion angles of 0, 15, 30 and 45 degrees using the navigation system. Internal or external rotation of legs was controlled within 5 degrees.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 122 - 122
1 Sep 2012
Nishii T Sakai T Takao M Yoshikawa H Sugano N
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Purpose

Ceramic-on-ceramic bearings in total hip arthroplasty (CoC THA) have theoretical advantages of wear resistance and favorable biocompatibility of ceramic particles to the surrounding bony and soft tissue. Long-time durability of CoC THA has been expected, however, clinical results over 10 years after operation were scarcely reported. In the present study, clinical results at follow of 10 years were examined for CoC THAs with a changeable femoral neck which allowed correction of anteversion of the femoral component in cases with abnormal femoral anteversion in dysplastic hips.

Methods

During 1997 and 2000, 203 cementless CoC THAs in 158 patients were conducted in our hospital. Six patients died because of unrelated causes and 5 patients were lost to followup, and the remaining 188 hips in 147 patients were analyzed at the mean followup period of 10.8 years (3.7 to 13.5). There were 24 men and 123 women, and the average age at operation was 54 years (26 to 73). The hip diseases for operation were osteoarthritis in 165 hips, osteonecrosis of the femoral head in 21 hips and failure of hemiarthroplasty in 2 hips. The operation was performed in the lateral position through the posterior approach without trochanteric osteotomy. The articulation was composed of Biolox forte alumina liner fitted into beads-coated hiemispherical titanium shell, and a 28-mm Biolox forte alumina femoral head (Cremascoli). The femoral component was either AnCA stem or custom-designed stem, coupled with a modular neck allowing selection of 5 variable offsets and anteversions (Cremascoli). Clinical and radiological findings, and complications during the followup period were analyzed.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 167 - 167
1 Jun 2012
Nakasone S Takao M Nishii T Sakai T Nakamura N Sugano N
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Introduction

Current standard cups of metal on metal resurfacing hip arthroplasty (RHA) have no dome holes and it is very difficult for surgeons to confirm full seating of these cups. This sometimes results in gap formation between the cup and acetabular floor. Although the incidence of initial gaps using modular press-fit cups with dome screw holes has been reported to range from 20 to 35%, few studies have reported the incidence of gap formation with monoblock metal cups and its clinical consequences in RHA. The purpose of this study was to investigate retrospectively the incidence of initial gap formation and whether the initial gap influences the clinical results in RHA.

Material and Method

RHA was performed on 166 hips of 146 patients using the Birmingham Hip Resurfacing (BHR) (MMT, UK) between 1998 and 2007. Mean age at operation was 48.7 years (range, 19-85 years). Mean duration of follow-up was 6.9 years (2.0-10.6). Acetabular reaming was performed with the use of hemispherical reamers and the reamer size was increased up to an odd number diameter which provided tight rim fit in the antero-posterior direction. The same size hemispherical provisional cup with dome holes and slits was used to check the cavity for complete seating. If the provisional cup could not be seated on the floor, reaming was repeated with the same reamer to remove the rim bump until full seating was achieved. Acetabular cups of 1mm larger diameter were impacted into the acetabulum by a press-fit technique. After press-fit fixation, the stability of the cups was confirmed with a synchronized movement of the pelvis and the cup inserter by applying a gentle torque. Clinical evaluation was performed using WOMAC at the latest follow-up. Radiographic assessments were performed using radiographs immediately after the surgery, at 3 weeks, 3 months, 1 year, and then annually thereafter. We evaluated the height of the gap between the cup and acetabular surface, cup inclination angle, cup migration and the time to gap filling. To investigate the relationship between the magnitude of the gap and the radiographic results, the patients were divided into two groups according to the height of the initial gap; the cases with a gap of less than 3 mm on the initial radiograph were grouped into a small gap group, the cases with a gap of 3mm or more were grouped into a large gap group. We compared the changes in the height of the gap, in the cup inclination angle and the cup migration between the groups.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 166 - 166
1 Jun 2012
Nakahara I Bandoh S Takao M Sakai T Nishii T Sugano N
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Introduction

The initial mechanical stability of cementless femoral stems in total hip arthroplasty is an important factor for stable biological fixation. Conversely, insufficient initial stability can lead to stem subsidence, and excessive subsidence can result in periprosthetic femoral fracture due to hoop stress. The surface roughness of stems with a surface coating theoretically contributes to initial mechanical stability by increasing friction against the bone, however, no reports have shown the effect of surface roughness on stability. The purpose of this study was to evaluate the effect of differences in surface roughness due to different surface treatments with the same stem design on the initial stability.

Materials and Methods

Proximally titanium plasma-sprayed femoral stems (PS stem) and proximally grit-blasted stems (GB stem) were compared. The stem design was identical with an anatomic short tapered shape for proximal fixation. The optimum size of PS stem based on 3D templating was implanted in one side of 11 pairs of human cadaveric femora and the same size of GB stems was implanted in the other side. After implantation, the specimens were fixed to the jig of a universal testing machine in 25cm of entire length so that the long axis of the femur was positioned at 15-degrees adduction to the vertical. Vertical load tests were conducted under 1 mm/minute of displacement-controlled conditions. After 200 N of preload to eliminate the variance in the magnitude of press-fit by manual implantation, load was applied until periprosthetic fracture occurred.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 229 - 229
1 May 2012
Yasui Y Takao M Matsushita T
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There have been few reports with efficient treatments for neglected distal tibiofibular syndesmosis disruption. Here we will report four cases of successful anatomical reconstruction with autologous gracilis tendon, using the interference fit anchoring (IFA) system.

All four cases were males between 20 and 58 years of age at the time of surgery (mean age 36 years). The post-injury period to surgery was between 7 and 59 months (mean 20.1 months), with the consultation period being from 5 to 19 months (mean 9.5 months). Radiographs at the time of injuries were all malleolar fractures of pronation-external rotation (PE) stage 3 in the Lauge-Hansen classification.

Stress tests for distal tibiofibular syndesmosis were positive in all cases (dilation more than 2 mm). Arthroscopic drilling was conducted in two cases with a cartilaginous injury of trochlea of talus. Distal tibiofibular syndesmosis was anatomically repositioned and was fixed with screws after bony and soft tissues within the tibiofibular syndesmosis were removed and fibular adhesion was dissected. Ipsilateral autologous gracilis tendon was passed through foramen in the insertion of the anterior inferior tibiofibular tendon on tibia and fibula, and was fixated using the IFA system.

The preoperative Japanese society for surgery of the foot (JSSF) score was from 26 to 74 points (mean 43.5) and postoperative JSSF score was from 67 to 100 (mean 89.5). In a case where there was a poor outcome, five years of post injury had passed before the surgery. Although the JSSF score improved to 67 points postoperatively (from the preoperative score of 26) in this case, arthroscopic arthrodesis was conducted 5 months postoperatively due to persistent pain.

Anatomical reconstruction with autologous gracilis tendon using the IFA system showed a favorable functional prognosis overall. However, there was a case with progressive degenerated changes of injured distal tibiofibular syndesmosis due to a prolonged post-injury period resulted in a poor outcome.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 40 - 40
1 Mar 2012
Takao M Nishii T Sakai T Nakamura N Yoshikawa H Sugano N
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Introduction

Lesion location and volume are critical factors to select patients with osteonecrosis for whom resurfacing arthroplasty is appropriate. However, no reliable surgical planning system which can assess relationship between necrotic lesions and the femoral component has been established. We have developed a 3D-MRI-based planning system for resurfacing arthroplasty. The purpose of the present study was to evaluate its feasibility.

Methods

The subjects included five patients with osteonecrosis of ARCO stage 3 or 4 who had undergone resurfacing THA at our institute. All patients had an MRI before surgery using 3D-SPGR sequences and fat suppression 3D-SPGR sequencea. In cases where it was difficult to distinguish bone marrow edema and reparative zone on 3D-SPGR images, fat suppression 3D-SPGR sequences were used. Simulation of resurfacing arthroplasty was performed on image analysis software where multidirectional oblique views could be reconstructed. The femoral neck axis was determined by drawing line through centers of two spheres which were fitted to the normal portion of the femoral head and the mid-portion of femoral neck. A femoral component was virtually implanted to align the femoral neck axis and match the implant center and femoral head center.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 10 - 10
1 Mar 2012
Nishii T Sakai T Takao M Yoshikawa H Sugano N
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Introduction

In osteonecrosis of the femoral head (ONFH), progression of collapse is influenced by a repair reaction, especially bone resorptive activity, around the necrotic bone. Alendronate is a potent inhibitor of bone resorption by inhibiting osteoclast activity. We performed a clinical study to test if systemic alendronate treatment would prevent the development of collapse in patients with ONFH.

Methods

Thirty-three hips in 22 ONFH patients with initial ARCO Stage 1 to 3 were included. Fourteen patients (20 hips) received daily administration of oral alendronate 5mg/day (alendronate group) and 8 patients (13 hips) did not receive alendronate administration (Control group). Baseline investigations included anteroposterior and lateral plain radiographs, T1-weighted magnetic resonance imaging (MRI), and biochemical markers (urinary NTX and serum BAP). Examination of the biochemical markers were repeated at 3, 6, and 12 months, and MRI imaging was repeated at 12 months. At 3 years, clinical symptoms and findings on plain radiographs were compared between the 2 groups. Advancement of ARCO stages or increase of collapse by more than 2 mm were considered as development of collapse.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 54 - 54
1 Mar 2012
Sakai T Nakamura N Iwana D Kitada M Nishii T Takao M Yoshikawa H Sugano N
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Introduction

Femoral neck fracture (FNF) is a common trauma in the elderly individuals. When the blood supply to the femoral head is impaired with a fracture event, the reduction or disruption of blood supply to the bone, hypoxia, leads to death of the bone marrow and trabecular bone, and eventual late segmental collapse. In the reparative process, osteoblasts and osteoclasts perform the important function of repairing the fracture site at the femoral neck. However, the reparative reaction including angiogenesis and osteogenesis remains unknown. In order to investigate the reparative reaction in patients with FNF, the distribution of tartrate resistant acid phosphatase (TRAP)-positive cells and expression of HIF-1 alpha, VEGF, and FGF-2 were observed in 36 hips in 35 patients.

Methods

There were 6 men and 30 women who had a mean age of 79 years (range, 58 to 94 years). There were 10 hips with Garden stage 3, and 26 hips with Garden stage 4. The mean duration from onset to the surgery was 12 days (range: 1 to 82 days). Hematoxylin eosin staining, TRAP staining, immunohistochemistry using anti HIF-1 alpha, anti VEGF, and anti FGF-2 antibodies were performed for retrieved whole femoral heads. As a control, one femoral head in a patient who underwent wide resection for metastatic acetabular tumor was used.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 448 - 449
1 Nov 2011
Nakahara I Nakamura N Miki H Takao M Sakai T Nishii T Yoshikawa H N.
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Using a larger diameter femoral head in total hip arthroplasty (THA) has advantages in terms of the increased joint stability and range of motion. And the wear resistance of highly cross-linked polyethylene (HXLPE) even combined with a larger head has already been demonstrated by in vitro studies. The purpose of this study was to compare the in vivo wear of Longevity HXLPE sockets against 32 mm and 26 mm heads at a 5-year follow-up.

From November 2000 to November 2001, 51 primary cementless THAs were performed with a 26 mm cobalt-chromium head and a Longevity HXLPE socket (Zimmer). A cohort of 32 mm cobalt-chromium heads was comprised of 51 THAs with the same prosthesis performed from December 2001 to December 2003. No significant differences between the groups were observed in gender, age, and BMI, however, polyethylene liners with 32 mm heads were significantly thinner than those with 26 mm heads. Two-dimensional linear wear was measured using PolyWare software on annual x-rays, and total head penetration rates at postoperative 5-year and steady state wear rates were calculated. In addition, periprosthetic osteolysis was evaluated.

At the 5-year follow-up, the total head penetration rates were 0.047±0.022 mm/year with 26 mm heads and 0.048±0.026 mm/year with 32 mm heads. The steady state wear rates were −0.008 mm/year with 26 mm heads and 0.001 mm/year with 32 mm heads. No significant differences were seen between the two groups (p=0.82 and p=0.24). Osteolysis was not observed around pros-theses in any hips.

At the 5-year follow-up, the wear rate of Longevity HXLPE was very low. A Longevity HXLPE socket will undergo the same level of wear whether with a 32 mm head or a 26 mm head.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 9 | Pages 1215 - 1221
1 Sep 2010
Sakai T Ohzono K Nishii T Miki H Takao M Sugano N

The long-term results of grafting with hydroxyapatite granules for acetabular deficiency in revision total hip replacement are not well known. We have evaluated the results of revision using a modular cup with hydroxyapatite grafting for Paprosky type 2 and 3 acetabular defects at a minimum of ten years’ follow-up. We retrospectively reviewed 49 acetabular revisions at a mean of 135 months (120 to 178). There was one type 2B, ten 2C, 28 3A and ten 3B hips. With loosening as the endpoint, the survival rate was 74.2% (95% confidence interval 58.3 to 90.1). Radiologically, four of the type 3A hips (14%) and six of the type 3B hips (60%) showed aseptic loosening with collapse of the hydroxyapatite layer, whereas no loosening occurred in type 2 hips. There was consolidation of the hydroxyapatite layer in 33 hips (66%). Loosening was detected in nine of 29 hips (31%) without cement and in one of 20 hips (5%) with cement (p = 0.03, Fisher’s exact probability test). The linear wear and annual wear rate did not correlate with loosening.

These results suggest that the long-term results of hydroxyapatite grafting with cement for type 2 and 3A hips are encouraging.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 6 | Pages 770 - 776
1 Jun 2010
Sakai T Ohzono K Nishii T Miki H Takao M Sugano N

We compared a modular neck system with a non-modular system in a cementless anatomical total hip replacement (THR). Each group consisted of 74 hips with developmental hip dysplasia. Both groups had the same cementless acetabular component and the same articulation, which consisted of a conventional polyethylene liner and a 28 mm alumina head. The mean follow-up was 14.5 years (13 to 15), at which point there were significant differences in the mean total Harris hip score (modular/non-modular: 98.6 (64 to 100)/93.8 (68 to 100)), the mean range of abduction (32° (15° to 40°)/28 (0° to 40°)), use of a 10° elevated liner (31%/100%), the incidence of osteolysis (27%/79.7%) and the incidence of equal leg lengths (≥ 6 mm, 92%/61%). There was no disassociation or fracture of the modular neck.

The modular system reduces the need for an elevated liner, thereby reducing the incidence of osteolysis. It gives a better range of movement and allows the surgeon to make an accurate adjustment of leg length.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 145 - 145
1 Mar 2010
Nakahara I Nakamura N Miki H Takao M Sakai T Nishii T Yoshikawa H Sugano N
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Ceramic heads and highly cross-linked polyethylene (HXLPE) as bearing surface materials have been introduced to reduce the production of polyethylene wear particles. The present study hypothesized that the wear rate of HXLPE could be further reduced when combined with a ceramic head. The purpose of this study was to compare the in vivo wear of Longevity HXLPE against cobalt-chromium and zirconia heads after a minimum 5-year follow-up.

A prospective cohort study was performed in 102 cementless total hip arthroplasties (THAs) with the Longevity HXLPE socket (Zimmer) between June 2000 and October 2001. Same prostheses were used in all cases both acetabular cups (Trilogy; Zimmer) and femoral stems (Versys Fiber Metal Taper; Zimmer). 26-mm zirconia heads (NGK) or 26-mm cobalt-chromium heads (Zimmer) were randomly used in 51 hips each. A minimum 5-year follow-up was completed for 47 hips with zirconia heads and 46 hips with cobalt-chromium heads. Two-dimensional linear wear of Longevity HXLPE was measured using computer-assisted methods (PolyWare) on annual x-rays, and total head penetration rates and steady state wear rates were calculated. In addition, periprosthetic osteolysis was evaluated.

At a mean 6-year follow-up, the total head penetration rates were 0.034±0.016 mm/year (zirconia) and 0.031±0.015 mm/year (cobalt-chromium). The steady state wear rates were −0.01 mm/year (zirconia) and −0.01 mm/year (cobalt-chromium). No significant difference was seen between the two groups (p=0.4 and p=0.91). Osteolysis was not observed around prostheses in any hips.

In conclusion, no advantage was seen for the zirconia head compared with the cobalt-chromium head in this time period.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 110 - 110
1 Mar 2010
Tsuda K Miki H Kitada M Nakamura N Nishii T Sakai T Takao M Suzuki N Sugano N
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The anterior pelvic plane (APP) through the bilateral anterior superior iliac spines (ASIS) and pubic tuberosities is often used as a pelvic reference in measuring orientation of the acetabular cup in total hip arthroplasty. Apophyses such as ASIS are, however, anatomically variable among patients and APP does not always represent the functional pelvic tilt in the sagittal plane in each patient. Therefore, malposition of the cup and recurrent dislocation may occur even though the cup is placed in a safe zone when measured against APP. We analyzed dynamic pelvic tilt angle in the sagittal plane using a motion analysis system after THA and we found a case of recurrent dislocation due to an unusual APP tilt.

A 77-year-old woman underwent primary THA 3 years ago and cup re-implantation was done with the use of a 10-degree elevated liner and the head diameter was increased from 26mm to 28 mm after two anterior dislocations. However, posterior dislocation occurred 11 times after this. A second revision was performed with a 36 mm head and cup anteversion was optimized against APP. Further posterior dislocations occurred twice again. To probe the cause of recurrent dislocation, we performed motion analysis using a 6-camera VICON system and the markers were registered to the bone and implant models based on the postoperative CT images. This system visually represents four-dimensional dynamic motions that include the time sequential transitions of components and their posture. The cup had been placed in 6 degrees of radiographic anteversion against APP, and in −13 degrees of radiographic retroversion in supine (FPP), because the pelvic flexion angle in supine was 17.6 degrees. Furthermore, when standing, the pelvic flexion angle increased 10 degrees.

Malposition of the acetabular cup in THA is the most common cause of dislocation. To avoid errors in cup placement, computer navigation systems have been introduced and most of the navigation systems refer APP to establish cup orientation. There are two drawbacks in using APP as the reference. One is that apophyses such as ASIS develop variably in each patient with a resulting variability in APP tilt in the sagittal plane in supine. The other is significant changes in pelvis tilt during various activities of daily living such as standing, walking, and sitting. Therefore, even if cup orientation is acceptable when referencing APP, it can be mal-oriented in a functional position of the pelvis as in this case, which showed proper anteversion against APP but retroversion in supine, standing and sitting.

In conclusion, we found that there exists a case in which APP is not a suitable pelvic reference in determining orientation of the cup.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 167 - 167
1 Mar 2010
Sugano N Nishii T Miki H Sakai T Takao M Ohzono K
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To analyze the long term results of a third generation ceramic on ceramic bearing in cementless total hip arthroplasty (THA), we reviewed the clinical and radiological results of 100 consecutive THAs performed in 86 patients (68 females, 80 hips; 18 males, 20 hips) between 1996 and 1998. The average age at operation was 55 years with a range of 26 to 73 years. The diagnoses were osteoarthritis in 83 hips, osteonecrosis in 10 hips and rheumatoid arthritis in 7 hips. The articulation was composed of a hemispherical titanium porous bead-coated cup (AnCA), a Biolox Forte alumina ceramic cup liner and a ball with a diameter of 28-mm. The modular ceramic liner was fixed directly to the metal cup without polyethylene sandwich or metal rim. A press-fit technique of 1 mm under-reaming without screws was used for cup fixation. The ceramic head was fixed to a 12/14 taper cone of a modular neck which allowed changes in neck-shaft angle, anteversion, and offset. All operations were performed via a posterolateral approach under general anesthesia. To measure the cup orientation, an ellipse was fitted to the acetabular component rim on the early postoperative AP radiographs using computer software. The average cup inclination and anteversion in the radiographic definition were 41 (range 28 to 63) and 17 (range 3 to 34) degrees, respectively. 22 cups were outside the Lewinnek safe zone. All patients were radiographically evaluated in term of implant stability at two years using Engh’s criteria. All of the acetabular components radiologically were judged to be bone-ingrown stable at two years except one cup. 98 stems were judged to be bone-ingrown stable and the remaining two stems were judged to be fibrous stable at two years. After two years, all patients except for two were followed up clinically and radiologically for at least 10 years or until revision or death. One unstable cup was revised at 2.5 years. This case had a previous Chiari’s pelvic osteotomy and insufficient press-fit of the cup was assumed to have led to loosening. One of the two fibrous stable stems was revised at six years due to aseptic loosening. One rheumatoid arthritis hip with stable bone ingrown fixation developed late infection at six years and was revised. One stable cup showed chipping of the acetabular liner at 8 years and required revision. The orientation of this cup was 55 degrees of inclination and 17 degrees of anteversion and the high inclination was thought to be related to the ceramic liner chipping. The remaining hips showed no osteolysis or loosening at the final follow-up. There were no squeaking hips. The 10-year survivorships with the endpoint of mechanical loosening or revision were 96.7% and 95.6%, respectively. We conclude that the third generation ceramic on ceramic hip bearing without polyethylene sandwich provided long term stability and eliminated periprosthetic osteolysis.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 178 - 178
1 Mar 2008
Nishii T Sugano N Miki H Takao M Koyama T Yoshikawa H
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Alendronate is a potent inhibitor of bone resorptive activity, and has been shown to prevent and restore periprosthetic osteolysis in experimental models. A preliminary study was conducted to examine clinical usefulness of a lendronate treatment.

Twenty-five patients (27 hips) with radiological evidence of osteolysis after cemented total hip arthroplasty were included. Of these, 14 patients (15 hips) were administered 5 mg of alendronate daily (alendronate group), and 11 patients (12 hips) did not receive alendronate treatment (control group). The subjects were followed up for 12 months, using radiological examinations and biochemical markers. The radiological analysis was evaluated blindly by 2 joint arthroplasty experts, each with more than 10 years of experience, without knowledge of alendronate administration.

In the alendronate group, average serum bone alkaline phosphatase and urinary excretion of the N-telopep-tide of type I collagen values decreased from the baseline values after administration of alendronate, to 71% and 76% of baseline at the 3-month examination, and 57% and 62% at the 1-year examination, respectively. In the control group, expansion of osteolysis was found in 5 hips (42%) and no hip showed restoration of osteolysis. In the alendronate group, expansion of osteolysiswas found in 2 hips (13%), and restoration of osteolysis was found in 5 hips (33%). There was a statistically significant difference in ratio of hips with osteolysis restoration between the 2 groups (p< 0.05). In the alendronate group, there was no significant difference in age, average linear wear rate of polyethylene, and the biochemical markers, between the hips with and without diminishment of osteolysis.

Conclusions: The present results indicate that clinicala-lendronate treatment can prevent and restore periprosthetic osteolysis, which is generally thought to require surgical intervention. These findings warrant further study of the effects of duration and dose of alendronate treatment, component materials, and component fixation methods.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 148 - 148
1 Feb 2004
Nishii T Sugano N Miki H Takao M Koyama T Nakamura N Yoshikawa H
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Introduction: Progression of collapse in osteonecrosis of the femoral head (ONFH) is greatly influenced by repair reactions, especially bone resorptive activity. This study was performed to test if systemic alendronate treatment, a potent inhibitor of osteoclast activity, can prevent the development of collapse in ONFH.

Materials and Methods: Daily administration of oral alendronate (5mg/day) was started in 14 hips in 11 patients with ONFH (Alendronate group). At the beginning of the study (3, 6, 12 months), plain radiographs, T1-weighted MR imaging, and biochemical makers of osteoclast activity (N-telopeptide of type-I collagen) and osteoblast activity (Bone-specific alkaline phosphatase), were examined. At 12 months, MR imaging was repeated. Eleven hips in 6 patients with ONFH who did not receive alendronate administration were considered as the control group.

Results: There was no significant difference with respect to gender distribution, etiology factors, initial ARCO stages, and extent of necrosis in the two groups. In the alendronate group, there was an early decrease of osteoclast activity at 3 months, with a decrease to 62% at 12 months, while the decrease of osteoblast activity was smaller with 80% at 12 months. Development of collapse was observed in 4 of the 11 hips (36%) in the control group, and in none of the 14 hips in the alendronate group. There was a significant difference of collapse development between the two groups (p=0.026, Mann-Whitney U-test). Signal change on serial MR images was observed in 5 of 9 hips (56%) in the control group, with only one of 9 hips (11%) in the alendronate group.

Discussion: The low incidence of signal change on serial MR images may reflect the decrease of repair activity in the alendronate group. The present study was the first clinical trial to show that alendronate has a significant preventive effect of collapse development in patients with osteonecrosis of the femoral head.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 145 - 145
1 Feb 2004
Takao M Sugano N Nishii T Masumoto J Miki H Sato Y Tamura S Yoshikawa H
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Introduction: There is controversy over whether the lesions of osteonecrosis of the femoral head (ONFH) will spontaneously decrease. This study reports a longitudinal study of lesion volume using high-resolution serial MRI and recently developed techniques for image registration to realign serial images.

Materials and Methods: Baseline and follow-up (minimum one year later) MRI scans were carried out on 15 patients (18 hips). Accurate subvoxel registration was performed and subtraction images were produced to reveal areas of regional necrotic lesion change. Volume-to-femoral head ratio (VFR) was calculated to normalize the measured volume to the total femoral head volume.

Results: Three of 18 hips showed spontaneous reductions in the size of the lesions. They were all related to steroid use and were within one year after initial steroid treatment The mean volume decrease of these 3 hips was 3.4 ± 2.0 cm3 (SD) and its VFR was 6.8 ± 3.1 % (SD). Mean necrotic lesion volumes at baseline of decreasing lesions and unchanged lesions were 4.6 ± 2.5 cm3 (VFR, 9.1 ± 3.9 %) and 7.5 ± 5.5 cm3 (VFR, 16.7 ± 12.4 %), respectively.

There was no statistically significant difference in baseline lesion volume between decreasing lesions and unchanged lesions.

Discussion: In conclusion, some early lesions within one year after onset can decrease in size on MRI, regardless their size at baseline.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 145 - 145
1 Feb 2004
Sakai T Ohzono K Lee S Sugano N Nishii T Miki H Takao M Koyama T Morimoto D Yoshikawa H
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Introduction: In order to investigate the relationship between the degeneration of the acetabular cartilage and the radiological staging of osteonecrosis of the femoral head, the following study was performed.

Materials and Methods: Acetabular cartilage with sub-chondral bone was taken from the superior dome from 34 hips from 30 patients undergoing total hip arthroplasty due to osteonecrosis of the femoral head. The specimens were stained with hematoxylineosin and safranin-O, and were evaluated as to the thinning of cartilage, fibrillation, clefts, and proliferation of chondrocytes. There were 18 females and 12 males with an average age of 49 years. We used the radiological staging system proposed by the working group of the Specific Disease Investigation Committee under the auspices of the Japanese Ministry of Health, Labor and Welfare. There were eight hips in stage IIIA disease (collapse of the femoral head less than 3 mm), 19 hips in stage IIIB disease (collapse 3 mm or greater), and seven stage IV disease hips.

Results: All 34 specimens showed histological abnormalities. In eight stage IIIA hips, six hips were mild and two were moderate histological degeneration. In 19 stage IIIB hips, five hips were mild, six were moderate, and eight had severe arthrosis. Seven stage IV hips had severe arthrosis.

Discussion: Although the radiographs cannot demonstrate early degeneration of cartilage, degenerative changes were present in all stage III hips. Histological degenerative changes in stage IIIB hips were more severe than those in stage IIIA hips. These findings should be kept in mind in treating patients with osteonecrosis of the femoral head.


The Journal of Bone & Joint Surgery British Volume
Vol. 85-B, Issue 3 | Pages 324 - 329
1 Apr 2003
Takao M Ochi M Oae K Naito K Uchio Y

In 52 patients we compared the accuracy of standard anteroposterior (AP) radiography, mortise radiography and MRI with arthroscopy of the ankle for the diagnosis of a tear of the tibiofibular syndesmosis. In comparison with arthroscopy, the sensitivity, specificity and accuracy were 44.1%, 100% and 63.5% for standard AP radiography and 58.3%, 100% and 71.2% for mortise radiography. For MRI they were 100%, 93.1% and 96.2% for a tear of the anterior inferior tibiofibular ligament and 100%, 100% and 100% for a tear of the posterior inferior tibiofibular ligament. Standard AP and mortise radiography did not always provide a correct diagnosis. MRI was useful although there were two-false positive cases. We suggest that arthroscopy of the ankle is indispensable for the accurate diagnosis of a tear of the tibiofibular syndesmosis.