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The Bone & Joint Journal
Vol. 105-B, Issue 2 | Pages 124 - 134
1 Feb 2023
Jain S Farook MZ Aslam-Pervez N Amer M Martin DH Unnithan A Middleton R Dunlop DG Scott CEH West R Pandit H

Aims

The aim of this study was to compare open reduction and internal fixation (ORIF) with revision surgery for the surgical management of Unified Classification System (UCS) type B periprosthetic femoral fractures around cemented polished taper-slip femoral components following primary total hip arthroplasty (THA).

Methods

Data were collected for patients admitted to five UK centres. The primary outcome measure was the two-year reoperation rate. Secondary outcomes were time to surgery, transfusion requirements, critical care requirements, length of stay, two-year local complication rates, six-month systemic complication rates, and mortality rates. Comparisons were made by the form of treatment (ORIF vs revision) and UCS type (B1 vs B2/B3). Kaplan-Meier survival analysis was performed with two-year reoperation for any reason as the endpoint.


The Bone & Joint Journal
Vol. 104-B, Issue 7 | Pages 833 - 843
1 Jul 2022
Kayani B Baawa-Ameyaw J Fontalis A Tahmassebi J Wardle N Middleton R Stephen A Hutchinson J Haddad FS

Aims

This study reports the ten-year wear rates, incidence of osteolysis, clinical outcomes, and complications of a multicentre randomized controlled trial comparing oxidized zirconium (OxZr) versus cobalt-chrome (CoCr) femoral heads with ultra-high molecular weight polyethylene (UHMWPE) and highly cross-linked polyethylene (XLPE) liners in total hip arthroplasty (THA).

Methods

Patients undergoing primary THA were recruited from four institutions and prospectively allocated to the following treatment groups: Group A, CoCr femoral head with XLPE liner; Group B, OxZr femoral head with XLPE liner; and Group C, OxZr femoral head with UHMWPE liner. All study patients and assessors recording outcomes were blinded to the treatment groups. The outcomes of 262 study patients were analyzed at ten years’ follow-up.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_7 | Pages 30 - 30
1 Jul 2022
Middleton R Jackson W Alvand A Bottomley N Price A
Full Access

Abstract

Background

Since 2012 we have routinely used the cementless Oxford medial unicompartmental knee arthroplasty (mUKA), with microplasty instrumentation, in patients with anteromedial osteoarthritis (AMOA) meeting modern indications. We report the 10-year survival of 1000 mUKA with minimum 4-year follow-up.

Methods

National Joint Registry (NJR) surgeon reports were interrogated for each senior author to identify the first 1,000 mUKAs performed for osteoarthritis. A minimum of 4 years follow-up was required. There was no loss to follow-up. The NJR status of each knee was established. For each mUKA revision the indication and mechanism of failure was determined using local patient records. The 10-year implant survival was calculated using life-table analysis.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_4 | Pages 18 - 18
1 Apr 2022
Kayani B Baawa J Fontalis A Tahmassebi J Wardle N Middleton R Hutchinson J Haddad FS
Full Access

This study reports the ten-year polyethylene liner wear rates, incidence of osteolysis, clinical outcomes and complications of a three-arm, multicentre randomised controlled trial comparing Cobalt-Chrome (CoCr) and Oxidised Zirconium (OxZr) femoral heads with ultra-high molecular weight polyethylene (UHMWPE) versus highly cross-linked polyethylene (XLPE) liners in total hip arthroplasty (THA).

Patients undergoing THA from four institutions were prospectively randomised into three groups. Group A received a CoCr femoral head and XLPE liner; Group B received an OxZr femoral head and XLPE liner; and Group C received an OxZr femoral head and UHMWPE liner. Blinded observers recorded predefined outcomes in 262 study patients at regular intervals for ten years following THA.

At ten years follow-up, increased linear wear rates were recorded in group C compared to group A (0.133 ± 0.21 mm/yr vs 0.031 ± 0.07 mm/yr respectively, p<0.001) and group B (0.133 ± 0.21 mm/yr vs 0.022 ± 0.05 mm/yr respectively, p<0.001). Patients in group C were associated with increased risk of osteolysis and aseptic loosening requiring revision surgery compared with group A (7/133 vs 0/133 respectively, p=0.007) and group B (7/133 vs 0/135 respectively, p=0.007). There was a non-significant trend towards increased liner wear rates in group A compared to group B (0.031 ± 0.07 mm/yr vs 0.022 ± 0.05 mm/yr respectively, p=0.128). All three groups were statistically comparable preoperatively and at ten years follow-up when measuring normalised Western Ontario and McMaster Universities Osteoarthritis Index(p=0.410), short-form-36 (p = 0.465 mental, p = 0.713 physical), and pain scale scores (p=0.451).

The use of UHMWPE was associated with progressively increased annual liner wear rates after THA. At ten years follow-up, this translated to UHMWPE leading to an increased incidence of osteolysis and aseptic loosening requiring revision THA, compared with XLPE. Femoral heads composed of OxZr were associated with a non-significant trend towards reduced wear rates compared to CoCr, but this did not translate to any differences in osteolysis, functional outcomes, or revision surgery between the two treatments groups.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 15 - 15
1 Nov 2021
Kayani B Bawwa J Tahmassebi J Fontalis A Wardle N Middleton R Shardlow D Hutchinson J Haddad F
Full Access

This study reports the ten-year outcomes of a three-arm, multicentre randomised controlled trial comparing Cobalt-Chrome (CoCr) and Oxidised Zirconium (OxZr) femoral heads with ultra-high molecular weight polyethylene (UHMWPE) versus highly cross-linked polyethylene (XLPE) liners in total hip arthroplasty (THA).

Patients undergoing THA from four institutions were prospectively randomised into three groups. Group A received a CoCr femoral head and XLPE liner; Group B received an OxZr femoral head and XLPE liner; and Group C received an OxZr femoral head and UHMWPE liner. The outcomes of 262 study patients were analysed at ten years follow-up.

At ten years, increased linear wear rates were recorded in group C compared to group A (0.133 ± 0.21 mm/yr vs 0.031 ± 0.07 mm/yr respectively, p<0.001) and group B (0.133 ± 0.21 mm/yr vs 0.022 ± 0.05 mm/yr respectively, p<0.001). Patients in group C had increased risk of osteolysis and aseptic loosening requiring revision surgery compared with group A (7/133 vs 0/133 respectively, p=0.007) and group B (7/133 vs 0/135 respectively, p=0.007). There was a non- significant trend towards increased liner wear rates in group A compared to group B (0.031 ± 0.07 mm/yr vs 0.022 ± 0.05 mm/yr respectively, p=0.128). All three groups were statistically comparable preoperatively and at ten years follow-up from a clinical score perspective.

The use of UHMWPE was associated with progressively increased annual liner wear rates. At ten years follow-up, this translated to an increased incidence of osteolysis and aseptic loosening requiring revision, compared with XLPE. Femoral heads composed of OxZr were associated with a non-significant trend towards reduced wear rates compared to CoCr, but this did not translate to any differences in osteolysis, functional outcomes, or revision surgery between the two treatments groups.


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_10 | Pages 10 - 10
1 Aug 2021
Jain S Lamb J Townsend O Scott C Kendrick B Middleton R Jones S Board T West R Pandit H
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Cemented total hip replacement (THR) provides excellent outcomes and is cost-effective. Polished taper-slip (PTS) stems demonstrate successful results and have overtaken traditional composite-beam (CB) stems. Recent reports indicate they are associated with a higher risk of postoperative periprosthetic femoral fracture (PFF) compared to CB stems. This study evaluates risk factors influencing fracture characteristics around PTS and CB cemented stems.

Data were collected for 584 PFF patients admitted to eight UK centres from 25/05/2006-01/03/2020. Radiographs were assessed for Unified Classification System (UCS) grade and Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA) type. Statistical comparisons investigated relationships by age, gender, and stem fixation philosophy (PTS versus CB). The effect of multiple variables was estimated using multinomial logistic regression to estimate odds ratios (OR) with 95% confidence intervals (CI).

Median (IQR) age was 79.1 (72.0–86.0) years, 312 (53.6%) patients were female, and 495 (85.1%) stems were PTS. The commonest UCS grade was type B1 (278, 47.6%). The commonest AO/OTA type was spiral (352, 60.3%). Metaphyseal-split fractures occurred only with PTS stems with an incidence of 10.1%. Male gender was associated with a five-fold reduction in odds of a type C fracture (OR 0.22, 95% CI 0.12 to 0.41, p<0.001) compared to a type B fracture. CB stems were associated with significantly increased odds of transverse fracture (OR 9.51, 95% CI 3.72 to 24.34, p <0.001) and wedge fracture (OR 3.72, 95% CI 1.16 to 11.95, p <0.05) compared to PTS stems.

This is the largest study investigating PFF characteristics around cemented stems. The commonest fracture types are B1 and spiral fractures. PTS stems are exclusively associated with metaphyseal-split fractures, but their incidence is low. Males have lower odds of UCS grade C fractures compared to females. CB stems had higher odds of bending type fractures (transverse and wedge) compared to PTS stems. Biomechanical testing is needed for validation and investigation of modifiable factors which may reduce the risk of unstable fracture patterns requiring complex revision surgery over internal fixation.


Bone & Joint Open
Vol. 2, Issue 7 | Pages 466 - 475
8 Jul 2021
Jain S Lamb J Townsend O Scott CEH Kendrick B Middleton R Jones SA Board T West R Pandit H

Aims

This study evaluates risk factors influencing fracture characteristics for postoperative periprosthetic femoral fractures (PFFs) around cemented stems in total hip arthroplasty.

Methods

Data were collected for PFF patients admitted to eight UK centres between 25 May 2006 and 1 March 2020. Radiographs were assessed for Unified Classification System (UCS) grade and AO/OTA type. Statistical comparisons investigated relationships by age, gender, and stem fixation philosophy (polished taper-slip (PTS) vs composite beam (CB)). The effect of multiple variables was estimated using multinomial logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs). Surgical treatment (revision vs fixation) was compared by UCS grade and AO/OTA type.


The Bone & Joint Journal
Vol. 102-B, Issue 12 | Pages 1670 - 1674
5 Dec 2020
Khan T Middleton R Alvand A Manktelow ARJ Scammell BE Ollivere BJ

Aims

To determine mortality risk after first revision total hip arthroplasty (THA) for periprosthetic femoral fracture (PFF), and to compare this to mortality risk after primary and first revision THA for other common indications.

Methods

The study cohort consisted of THAs recorded in the National Joint Registry between 2003 and 2015, linked to national mortality data. First revision THAs for PFF, infection, dislocation, and aseptic loosening were identified. We used a flexible parametric model to estimate the cumulative incidence function of death at 90 days, one year, and five years following first revision THA and primary THA, in the presence of further revision as a competing risk. Analysis covariates were age, sex, and American Society of Anesthesiologists (ASA) grade.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 9 - 9
1 Jul 2020
Uzoigwe C Mostafa A Middleton R
Full Access

Background

In a number of disciplines, positive correlations have been reported between volume and clinical outcome. This has helped drive the evolution of specialist centres to deal with complex or high risk medical conditions. Hip fractures are a common injury associated with high morbidity and mortality.

Aim

To assess whether volume of hip fracture cases attended to by individual hospitals is associated with the quality of care provided and clinical outcomes.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_5 | Pages 5 - 5
1 Jul 2020
Marusza C Lazizi M Hoade L Bartlett G Fern E Norton M Middleton R
Full Access

Introduction

Open and arthroscopic hip debridement may be used for treatment of femoral acetabular impingement (FAI). There is a paucity of evidence regarding the efficacy of one over the other.

Aim

To compare survivorship in terms of further surgical procedure at five years, in patients having undergone either arthroscopic or open hip debridement.


Bone & Joint 360
Vol. 8, Issue 4 | Pages 5 - 13
1 Aug 2019
Middleton R Khan T Alvand A


The Bone & Joint Journal
Vol. 100-B, Issue 12 | Pages 1572 - 1578
1 Dec 2018
Middleton R Wilson HA Alvand A Abram SGF Bottomley N Jackson W Price A

Aims

Our unit was identified as a negative outlier in the national patient-reported outcome measures (PROMs) programme, which has significant funding implications. As a centre that carries out a high volume of unicompartmental knee arthroplasty (UKA), our objectives were: 1) to determine whether the PROMs programme included primary UKA when calculating the gain in Oxford Knee Score (OKS); and 2) to determine the impact of excluding primary UKA on calculated OKS gains for primary knee arthroplasty.

Materials and Methods

National PROMs data from England (2012 to 2016) were analyzed. Inclusion of UKA cases in the national PROMs programme was determined using clinical codes. Local OKS gain was calculated for UKA and TKA and compared with the published PROMs results for 2012/13.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 3 - 3
1 May 2018
Onafowokan O Goubran A Hoade L Bartlett G Fern D Norton M Middleton R
Full Access

Introduction

Open hip debridement surgery has been used for treatment of femoral acetabular impingement pain for over ten years in our unit. While literature has reported promising short-term outcomes, longer term outcomes are more sparsely reported.

Patients/Materials & Methods

Patients who had undergone this surgery were identified on our database. Electronic, radiographic and paper records were reviewed. Demographic data, radiological and operative findings were recorded. Patients underwent ten-year review with standardised AP hip radiographs, questionnaire, non-arthritic hip (NAHS), Oxford hip (OHS) and SF-12 scores


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 36 - 36
1 Jun 2017
Maling L Offorha B Walker R Uzoigwe C Middleton R
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Hip fracture is a common injury with a high associated mortality. Many recommendations regarding timing of operative intervention exist for patients with such injuries. The Best Practice Tariff was introduced in England and Wales in 2010, offering financial incentives for surgery undertaken within 36 hours of admission. The England and Wales National Institute for Health and Clinical Excellence (NICE) Guidance states that surgery should be performed on the day or day after admission. Due to lack of clear evidence, this recommendation is based on Humanitarian grounds. NICE have called for further research into the effect of surgical timing on mortality.

We utilised data from the National Hip Fracture database prospectively collected between 2007 and 2015, comprising 413,063 hip fractures. Using 11 variables, both Cox and Logistic regression analysis was used to establish the effect on mortality of each 12 hour interval from admission to surgery.

For each 12 hour time frame from admission to surgery a trend for improved 30 day survival was demonstrated the earlier the surgery was performed. However, this did not reach significance until beyond 48 hours (Hazard ratio of 1.12, 95% CI: 1.04–1.20). Surgery after 48 hours suffered significantly higher chance of mortality compared to surgery done within 12 hours.

This is the largest analysis undertaken to date. Lowest mortality rates are found within the 0–12 hour window. After 48 hours there is a significant increased risk of mortality compared to the 0–12 hour time frame. As such, expeditious surgery within 48 hours can be justified both on humanitarian and survivorship grounds.

Hip fracture surgery performed within 48 hours is associated with reduced mortality when compared to that beyond this time. This is in agreement with Blue Book recommendations and extends the currently recommended NICE and Best Practice Tariff targets of 36 hours.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 19 - 19
1 Nov 2015
Middleton R Findlay I Onafowokan O Parmar D Bartlett G Fern E Norton M
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Introduction

Open hip debridement surgery has been used for treatment of femoral acetabular impingement pain for over ten years in our unit. While literature has reported promising short term outcomes, longer term outcomes are more sparsely reported. We aim to assess survivorship and functional outcome at ten years, in patients who have undergone open hip debridement.

Patients/Materials & Methods

All patients who had undergone open debridement surgery were identified on our database. The electronic, radiographic and paper records were reviewed. Demographic data, radiological and operative findings were recorded. All patients underwent ten year review with a standardised AP hips radiograph, questionnaire, non-arthritic hip score (NAHS), oxford hip score (OHS) and SF12 score.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 23 - 23
1 Nov 2015
Jonas S Middleton R
Full Access

Introduction

Incidence of adverse soft tissue reaction following metal on metal hip has a reported incidence of up to 48%. The current imaging modality of choice is metal artefact reduction sequence (MARS) MRI. Consensus is that large, symptomatic pseudotumours should be treated surgically, changing the bearing surfaces to other materials. There is debate as to how asymptomatic pseudotumours should be monitored and managed.

Patients/Materials & Methods

From our unit's database, 22 patients (7 female, 15 male) were identified with metal on metal hip replacements that had a ‘pseudotumour’ detected on MARS MRI but remained assymptomatic (mean 68 months post op). All underwent serial imaging and clinical follow up (mean interval 14.5 months).


The Bone & Joint Journal
Vol. 97-B, Issue 7 | Pages 883 - 889
1 Jul 2015
Jassim SS Patel S Wardle N Tahmassebi J Middleton R Shardlow DL Stephen A Hutchinson J Haddad FS

Oxidised zirconium (OxZi) has been developed as an alternative bearing surface for femoral heads in total hip arthroplasty (THA). This study has investigated polyethylene wear, functional outcomes and complications, comparing OxZi and cobalt–chrome (CoCr) as part of a three-arm, multicentre randomised controlled trial. Patients undergoing THA from four institutions were prospectively randomised into three groups. Group A received a CoCr femoral head and highly cross-linked polyethylene (XLPE) liner; Group B received an OxZi femoral head and XLPE liner; Group C received an OxZi femoral head and ultra-high molecular weight polyethylene (UHMWPE) liner. At five years, 368 patients had no statistically significant differences in short-form-36 (p = 0.176 mental, p = 0.756 physical), Western Ontario and McMaster Universities Osteoarthritis Index (p = 0.847), pain scores (p = 0.458) or complications. The mean rate of linear wear was 0.028 mm/year (standard deviation (sd) 0.010) for Group A, 0.023 mm/year (sd 0.010) for Group B, and 0.09 mm/year (sd 0.045) for Group C. Penetration was significantly higher in the UHMWPE liner group compared with both XLPE liner groups (p < 0.001) but no significant difference was noted between CoCr and OxZi when articulating with XLPE (p = 0.153). In this, the largest randomised study of this bearing surface, it appears that using a XLPE acetabular liner is more important in reducing THA component wear than the choice of femoral head bearing, at mid-term follow-up. There is a non-significant trend towards lower wear, coupling OxZi rather than CoCr with XLPE but long-term analysis is required to see if this observation changes with time and becomes significant.

Cite this article: Bone Joint J 2015;97-B:883–9.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_5 | Pages 10 - 10
1 Mar 2014
Lynch J Walker R Norton M Middleton R
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Routine postoperative radiographs following hip hemiarthroplasty are commonly undertaken despite it being suggested that they can cause delays to discharge, discomfort to patients and unnecessary radiation. Our study considered the necessity of these post-operative radiographs.

A retrospective search was conducted of all hemiarthroplasty procedures on the Royal Cornwall Hospital database. These were reviewed for cases where re-operation was conducted within 6 weeks. Notes and post-operative check radiographs of those who underwent re-operation were reviewed to determine how essential radiographs were in diagnosing complications requiring re-operations.

A total of 1557 hemiarthroplasty operations were identified. There were 37 incidences of re-operation within 6 weeks. 29 cases had normal check radiographs. 8 dislocations were picked up on post-operative radiographs. In all but one of these cases, clinical suspicion of complication had been raised prior to the radiograph. In the remaining case documentation was poor and no firm conclusion as to clinical suspicion could be drawn.

Our review of over 1500 hemiarthroplasty cases, demonstrated one incident where the check radiograph solely diagnosed an abnormality needing intervention that might not have been apparent clinically. We thus suggest that check radiographs following hip hemiarthroplasty should not be routinely ordered for all patients.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 186 - 186
1 Mar 2013
Jassim S Patel S Wardle N Tahmassebi J Middleton R Shardlow D Stephen A Hutchinson J Haddad F
Full Access

Introduction

In Total Hip Arthroplasty (THA), polyethylene wear reduction is key to implant longevity. Oxidized Zirconium (OxZi) unites properties of a ceramic bearing surface and metal head, producing less wear in comparison to standard Cobalt-Chromium (CoCr) when articulating with Cross-linked polyethylene (XLPE) in vitro. This study investigates in vivo polyethylene (PE) wear, outcomes and complications for these two bearing couples in patients at 5 year follow-up

Methods

400 patients undergoing THA across four institutions were prospectively randomised into three groups. Group I received a cobalt-chrome (CoCr) femoral head/ cross-linked polyethylene (XLPE) liner; Group II received an OxZi femoral head/ ultrahigh molecular weight polyethylene (UHMWPE) liner; Group III received an OxZi femoral head/XLPE liner. All bearing heads were 32 mm. Linear wear rate was calculated with Martell computer software. Functional outcome and complications were recorded.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 122 - 122
1 Jan 2013
Venkatesan M Uzoigwe C Middleton R Young P Burnand H Smith R
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Background and Purpose

Serum lactate has been shown to be an indicator of adverse clinical outcomes in patients admitted secondary to general trauma or sepsis. We retrospectively investigated whether admission serum venous lactate can predict in-hospital mortality in patients with hip fractures.

Method and Results

Over a 38-month period the admission venous lactate of 807 patients with hip fractures was collated. Mean age was 82 years. The overall in-hospital mortality for this cohort was 9.4%. Mortality was not influenced by the fracture pattern or the type of surgery - be it internal fixation or arthroplasty (p = 0.7). A critical threshold of 3 mmol/L with respect to the influence of venous lactate level on mortality was identified. Mortality rate in those with a lactate level of less than 3 mmol/L was 8.6% and 14.2% for those whose level was 3 mmol/L or greater. A 1 mmol/L increase in venous lactate was associated with a 1.2 (1.02–1.41) increased risk of in-hospital mortality. Patients with a venous lactate of 3 mmol/L or higher had twice the odds of death in hospital compared to matched individuals. There was no statistically significant difference in ASA distribution between those with a lactate of less than or greater than 3 mmol/L.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 198 - 198
1 Jan 2013
Alvand A Jackson W Khan T Middleton R Gill H Price A Rees J
Full Access

Introduction

Motion analysis is a validated method of assessing technical dexterity within surgical skills centers. A more accessible and cost-effective method of skills assessment is to use a global rating scale (GRS). We aimed to perform a validation experiment to compare an arthroscopic GRS against motion analysis for monitoring orthopaedic trainees learning simulated arthroscopic meniscal repairs.

Methods

An arthroscopic meniscal repair task on a knee simulator was set up in a bioskills laboratory. Nineteen orthopaedic trainees with no experience of meniscal repair were recruited and their performance assessed whilst undertaking a standardized meniscal repair on 12 occasions. An arthroscopic GRS, assessing parameters such as “depth perception,” “bimanual dexterity,” “instrument handling,” and “final product analysis” was used to evaluate technical skill. Performance was assessed blindly by watching video recordings of the arthroscopic tasks. Dexterity analysis was performed using a motion analysis tracking system which measured “time taken,” “total path length of the subject's hands,” and “number of hand movements”.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 18 - 18
1 Sep 2012
Middleton R Vasukutty N Young P Matthews E Uzoigwe C Minhas T
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Large studies have reported high dislocation rates (7 to 24%) following revision total hip arthroplasty (THA), particularly when the revision is undertaken in the presence of pre-existing instability. We retrospectively reviewed the clinical and radiographic outcome of 155 consecutive revision THA's that had been performed using an unconstrained dual-mobility acetabular implant. It features a mobile polyethylene liner articulating with both the prosthesis head and a metal acetabular cup, such that the liner acts as the femoral head in extreme positions. It can be implanted in either a press fit or cemented manner. Mean follow-up was 40 months (18–66) and average age 77 (42–89). Uncemented (n=122) and cemented (n=33) implants with a reinforcing cage, were used. Indications were aseptic loosening (n=113), recurrent instability (n=29), periprosthetic fracture (n=11) and sepsis (n=2). Three of the 155 cases (1.9%) dislocated within 6 weeks of surgery and were successfully managed with closed reduction. The 3 dislocations occurred in the groups revised for recurrent dislocation and periprosthetic fracture. There were no cases of recurrent dislocation and no revisions for implant failure. Despite a pantheon of options available, post-operative dislocation remains a challenge especially in patients with risk factors for instability. The use of large diameter heads is proven to improve stability but there are concerns regarding wear rates, metal toxicity and recurrent dislocation in the presence of abductor dysfunction. With constrained liners there are concerns regarding device failure and aseptic loosening due to implant overload. Our dislocation rates of 1.9% and survivorship to date compare favourably with alternative techniques and are also in line with studies from France using implants of a similar design. In our hands, where there are risk factors for dislocation, the use of a dual-mobility implant has been very effective at both restoring and maintaining stability in patients undergoing revision THA.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 304 - 304
1 Jul 2011
Holubowycz O Howie D Middleton R
Full Access

Background: Our multi-centre international randomized controlled trial compared the one-year incidence of dislocation between a 36 mm and 28 mm metal on highly cross-linked polyethylene articulation in primary and revision total hip replacement (THR).

Patients: 644 patients were entered into the study. Surgical approach was posterior in primary THR and posterior, transfemoral or transtrochanteric in revision THR. Patients were stratified according to a number of factors which may influence dislocation risk and polyethylene wear. Patients were randomized intra-operatively to either a 28 or 36 mm articulation.

Results: The 12-month incidence of dislocation was statistically significantly lower in patients undergoing THR with a 36 mm articulation than in those with a 28 mm articulation (1.3% vs 5.4%, p=.004). When primary and revision THR were examined separately, the 12-month incidence of dislocation was statistically significantly lower in patients undergoing primary THR with a 36 mm articulation than in those with a 28 mm articulation (0.8% vs 4.4%, p=.007). Of the 12 primary THR patients with a 28 mm articulation who dislocated within one year, four experienced recurrent dislocation and two were revised for dislocation. Two patients with a 36 mm articulation dislocated, one of whom experienced recurrent dislocation and was revised. The incidence of dislocation after revision THR with a 36 mm articulation was 4.9%, compared to 12.2% with a 28 mm articulation. Three of the five patients who dislocated following revision THR with a 28 mm articulation experienced recurrent dislocation and were revised within one year of surgery. Two patients dislocated following revision THR with a 36 mm articulation but neither experienced recurrent dislocation or further revision.

This large randomized study unequivocally shows for the first time that, compared to a 28 mm articulation, a 36 mm articulation in THR is efficacious in reducing the incidence of dislocation in the first year following THR.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 353 - 353
1 Jul 2011
Plakogiannis C Theruvil B Sisak K Middleton R
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In revision of cemented femoral components, removal of cement can be challenging. This study evaluates the use of an ultrasonic device (OSCAR, Orthosonics Ltd UK) for cement removal.

30 consecutive patients that attended our outpatients\’ clinic between May 2008 and September 2008, who underwent revision THR by the senior author or his fellows, were retrospectively reviewed. Minimum follow up was 12 months (average 34.9 months).Indications were aseptic loosening and recurrent dislocation. A posterolateral approach was used routinely. Cement was removed with osteotomes and OSCAR. An uncemented modular femoral component was used. At follow-up, radiographs were evaluated for the evidence of extended trochanteric osteotomy (ETO), fracture, cortical perforation, component loosening, migration, and adequacy of cement removal.

None of the cases required an ETO or cortical windowing. In 5 cases prophylactic cabling of the proximal femur was performed. There was one intraoperative femoral shaft fracture (3.33%). There was incomplete cement removal in 7 cases. There was no cortical perforation and no postoperative fracture. There was no case with loosening or migration of the implant.

In all cases that OSCAR was used ETO and cortical windowing were avoided. At an average 34.9 month follow up there was no evidence of thermal tissue damage. In the cases that cement was retained in the canal, this did not affect the stability of the implant. The fracture and the incomplete cement removal were in cases performed by a fellow illustrating the learning curve of the technique.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 89 - 89
1 May 2011
Price M Wainwright T Middleton R
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Aim: To evaluate the possible increase to surgical/operating room capacity by increasing the percentage of uncemented total hip replacement

Introduction: Globally there is growing demand for increased efficiency and productivity from medical care. In hip arthroplasty there has been increased interest in the use of uncemented components with several studies and registry data showing them to perform well clinically 1, 2. One concern with their increased use has been increased costs 3. We have examined the issue of operative timing and discuss the possible role these components may have in increasing theatre utilisation times and so offsetting their cost.

Methods: This was a prospective, cohort study of every hip replacement performed in a dedicated arthroplasty unit within a district general hospital over one year. All care of patients was standardised using pathways, including all surgeons using a posterior approach with posterior repair. This allowed us to determine the relative effect of prosthesis type on quality, safety and efficiency. Demographic, anaesthetic, operative and timing details on all cases performed were collected prospectively and independently of the surgical team. Patients were reviewed at six weeks and one year post op. All readmissions to any hospital were noted and any further surgery recorded.

Results: There were 1248 cases performed in one year. Of these 194 were uncemented (both components) and 286 cemented total hip replacements. Patient demographics were similar (mean age 70.9 years, range 28–92). Both hip types showed no difference in quality or safety factors as assessed by hip scores, patient mobilisation times, complication rates or revision rates. The only difference was in the surgical times. These were (in minutes):

– Mean Standard Deviation Minimum Maximum

– Uncemented 49 * 14 25 122

– Cemented 66 12 42 122

(*p< 0.0005)

Conclusions: Our data demonstrates an average time saving of 17 minutes per case performed. If, over the next year, we converted to all uncemented hips we would release 136 hours of operative time, giving an opportunity to get 100 more cases done. This represents a 20% increase in productivity with no compromise to safety or quality.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 518 - 518
1 Oct 2010
Holubowycz O Howie D Middleton R
Full Access

Early revision is an important risk factor for repeated revision and poor results after primary total hip replacement and instability is a major cause of early revision. Larger articulations with cross-linked polyethylene are proposed as a solution, but these are not without risk, including fracture of the thin polyethylene rim of the liner. The aim of our study was to examine implant-related revisions among primary total hip replacement patients with up to six year follow-up in a randomized controlled trial which compared 28 mm and 36 mm metal on highly cross-linked polyethylene articulations in total hip replacement.

557 patients undergoing primary total hip replacement were included in this study. Risk factors for dislocation and wear were controlled by stratification and patients were then randomized intra-operatively to either a 28 or 36 mm articulation.

To date, 10 hips have been revised for implant-related problems following primary total hip replacement. Seven hips with a 28 mm articulation were revised to a larger articulation because of instability. Four of these were for recurrent dislocation, one for an irreduceable first dislocation and two for subluxation. In contrast, only one patient who had undergone total hip replacement with a 36 mm articulation was revised for recurrent dislocation. One hip with a 36 mm articulation in a well-positioned cup was revised to a 32 mm articulation because of elevated lip liner fracture. Another 36 mm articulation hip was revised for acetabular component loosening.

This study shows that a 36 mm metal on highly cross-linked polyethylene articulation reduces the need for early revision for instability after primary total hip replacement. However, these benefits need to be weighed against the potential risks associated with these articulations, including rare fracture of the relatively thin poly-ethylene liner.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 518 - 518
1 Oct 2010
Holubowycz O Howie D Middleton R
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Large articulations using cross-linked polyethylene and other alternate bearings are increasingly being used to reduce the incidence of dislocation, the most common early complication following total hip replacement. While indirect evidence has suggested the potential benefits of a large articulation in reducing dislocation risk, this has not been proven in a well-controlled clinical trial. The primary objective of our multi-centre international randomized controlled trial was to compare the one-year incidence of dislocation between a 36 mm and 28 mm metal on highly cross-linked polyethylene articulation in primary and revision total hip replacement.

644 patients were entered into the study. Patients were stratified according to a number of factors which may influence dislocation risk, including primary or revision total hip replacement, age, sex, Charnley grade, diagnosis and stem type. Patients were randomized intra-operatively to either a 28 or 36 mm articulation.

The 12-month incidence of dislocation was statistically significantly lower in patients undergoing total hip replacement with a 36 mm articulation than in those with a 28 mm articulation (1.3% vs 5.2%, p< .05). A total of 6 dislocations occurred in the 4 patients who dislocated with a 36 mm articulation, compared to a total of 36 dislocations in the 17 patients who dislocated with a 28 mm articulation. When primary and revision THR were examined separately, the 12-month incidence of dislocation was statistically significantly lower in patients undergoing primary total hip replacement with a 36 mm articulation than in those with a 28 mm articulation (0.7% vs 4.2%, p< .05). A total of 4 dislocations occurred in two patients with a 36 mm articulation, compared to a total of 19 dislocations in 12 patients with a 28 mm articulation. The incidence of dislocation after revision total hip replacement with a 36 mm articulation was 4.8%, compared to 11.1% with a 28 mm articulation.

This large randomized study unequivocally shows for the first time that, compared to a 28 mm articulation, a 36 mm articulation in total hip replacement is efficacious in reducing the incidence of dislocation in the first year following hip replacement.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 500 - 500
1 Oct 2010
Vingerhoeds B Fick D Middleton R Olyslaegers C Wainwright T
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Summary: This study of 1000 patients demonstrates how you can dramatically reduce hospital length of stay, improve clinical outcomes, and increase patient satisfaction if a patient-centred pathway approach is adopted.

Introduction: This study evaluates the effect of adopting a patient-centred approach on clinical outcomes, patient satisfaction and operational efficiency. By adopting standardised working practices, dramatic changes can be achieved to reduce patient length of stay (LOS) and consequently surgical capacity.

Methods: We prospectively studied the first 1000 patients who followed the new pathway (549 Total Knee Replacements, 20 Unicondylar Knee Replacements, 384 Total Hip Replacements and 47 Hip resurfacings). The pathway included an enhanced pre-assessment process. Admission dates were mutually agreed and a predicted discharge date of 4 days was provided. All patients attended a pre-operative education session. Patients were admitted on the day of surgery and followed an intensive physiotherapy program. The surgeons, surgical techniques, and discharge criteria all remained unchanged.

Results: The average length of stay was 4.1 days (St Dev 1.8). 80% of patients went home on or before day 4 post-operatively. This was accompanied by a decreased re-admission rate (1.8%), low complication rates for both hip replacement (Dislocation rate = 0.93%) and knee replacement (Knee MUA = 0.87%) and no cases of deep infection. Pre-operative patient reported outcome measures (WOMAC, SF-12 and Oxford) all improved post-operatively (P< 0.0001) and qualitative data from patients was extremely positive towards the new pathway.

Discussion: The decrease in LOS was dramatic and highly clinically significant. The mean LOS for patients prior to commencing this new pathway was 7.5 days (St Dev 5.7). High patient satisfaction rates indicate that by adopting a patient-centred approach, significant decreases to LOS can be achieved alongside improving the quality of care with a low complication and readmission rate.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 9 - 9
1 Mar 2008
Odumala A Iqbal M Middleton R
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The aim of our study was to determine if the canal flare index of the proximal femur is a dependent factor in prosthetic failure after Austin Moore hemiarthroplasty.

We measured the canal flare index on A-P hip X-rays of 100 and 100 patients with failed and successful Austin Moore hemiarthroplasty respectively. We also measured the canal flare index of a control group of 100 patients without hip fractures. The canal flare index (CFI) is defined as the ratio of the width of the femoral canal at two levels: 20mm proximal to the centre of the lesser trochanter and the canal isthmus. Overall we reviewed 300 radiographs. The study group consisted of 68 males and 232 females. In the failed Austin Moore group there were 62 patients (62%) with loosening, 28 patients (28%) with dislocations and 10 patients (10%) with periprosthetic fractures. The canal flare index of the proximal femur was significantly higher in patients who had persistent thigh pain with radiological loosening in comparison the successful and control groups. (3.3 vs 2.6; 3.2 vs 2.7 respectively: p< 0.001). On the other hand patients with periprosthetic fractures had a lower canal flare index in comparison with the successful and control groups (2.1 vs 2.6; 2.1 vs 2.7 respectively: p< 0.001). However there was no differences in the CFI of patients with dislocations compared with successful (2.4 vs 2.6;p=0.1) and control groups (2.4 vs 2.7;p=0.2). This remained the same when controlled for age and sex in a logistic regression analysis.

Conclusion: The CFI can identify patients prone to persistent thigh pain who present as radiological loosening and to periprosthetic fractures and an alternative cemented prosthesis should be considered in this group of patients


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 79 - 79
1 Mar 2006
Sandhu H Middleton R Serjeant S
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Hip Resurfacing is now an established treatment option for young active patients with osteoarthritis. However, there is slow uptake of hip resurfacing by some surgeons, with concern regarding failure from femoral neck fracture, a small but significant risk. Femoral neck fracture may follow notching of the neck, which occurs upon preparing the femoral head after inserting the femoral head/neck guide-wire. The placement of the femoral head/neck guide-wire is a concern for even experienced surgeons routinely, and in difficult cases of femoral head/neck deformity this is especially so.

For the first time a preliminary series of Durom hip resurfacings, based on the successful Metasul bearing, were implanted using a computer image guidance system. The aim of computer navigation is to optimally place the femoral prosthesis in the correct degree of valgus with good underlying bone coverage, without notching the femoral neck or over-sizing the femoral component. Preoperative CT scanning was not required. A standard posterior approach to the hip was utilised, and a navigation reference frame was applied to the proximal femur. Then using an image intensifier and the computer navigation system, a guide-wire was passed quickly and easily into the femoral head/neck with a navigated drill guide. The femoral head was then prepared safely for the femoral component of the resurfacing, with minimal risk of femoral neck fracture.

Computer navigation systems have an important role to play in hip resurfacing with respect to femoral head/neck preparation, as demonstrated from our preliminary study. This series shows the use of computer navigation in hip resurfacing to be both SAFE and SIMPLE with a quick learning curve. It was shown to be FASTER and MORE ACCURATE in the process of guide-wire placement in the femoral head/neck as compared to conventional jigs. Crucially, femoral neck fractures may even be potentially ELIMINATED using this technique.

In the future, hip resurfacing in conjunction with computer navigation systems may allow;

- SAFER hip resurfacing, with reduced rates of femoral neck fractures

- Improved TRAINING to include junior surgeons in hip resurfacing

- Surgeons to operate INDEPENDENTLY initially

- Surgeons to operate on DIFFICULT cases subsequently

- The development of MINIMALLY INVASIVE hip resurfacing

- The development of SPECIALIST centres for teaching and difficult cases


The Journal of Bone & Joint Surgery British Volume
Vol. 69-B, Issue 3 | Pages 429 - 432
1 May 1987
Middleton R Frost R

This paper describes the design, development and early surgical experience with a stereotactic device to allow closed retrieval and interchange of intramedullary rods in children with osteogenesis imperfecta. This relatively atraumatic procedure may allow more frequent rod interchange than with other techniques, lessening the likelihood of deformity and fracture in the unsupported skeleton when the bone has outgrown the intramedullary rod. The procedure was developed by design studies in vitro followed by intramedullary rodding of tibiae of New Zealand white rabbits. It has been used in children 12 times, in six tibiae and six femora: 11 rods have been successfully retrieved, with rod interchange in eight of these cases.


The Journal of Bone & Joint Surgery British Volume
Vol. 66-B, Issue 5 | Pages 652 - 655
1 Nov 1984
Middleton R

Three cases of severe osteogenesis imperfecta are reported. Each was treated by closed intramedullary rodding, combined with osteoclasis to correct deformity. Operation was performed within a few months of birth. Both tibiae and both femora were stabilised in one operation, using x-ray image intensification to monitor placement of the rods. The technique used to insert the rods is described. The procedure appeared to be entirely satisfactory in reducing the incidence of fractures and it allowed the affected infants to be handled much more easily.


The Journal of Bone & Joint Surgery British Volume
Vol. 66-B, Issue 4 | Pages 566 - 572
1 Aug 1984
Bellemore M Barrett I Middleton R Scougall J Whiteway D

Cubitus varus is the most common complication of supracondylar fracture of the humerus in children. Although function of the elbow is not greatly impaired, the deformity is unsightly. It usually results from malunion, since growth disturbance of the humerus after this fracture is uncommon. The normal carrying angle can be restored by supracondylar osteotomy. This operation was done in 32 patients over a ten-year period, 16 of them using the technique described by French (1959). The results in 27 patients are reviewed in the light of previous reports. French's method proved safe and satisfactory.