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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 46 - 46
1 Jan 2011
Mounsey E Williams D Howell J Hubble M Timperley A Gie G
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The cement in cement technique for revision total hip arthroplasty (THA) has shown good results in selected cases. However results of its use in the revision of hemiarthroplasty to THA has not been previously reported.

Between May 1994 and May 2007 28 (20 Thompson’s and 8 Exeter bipolar) hip hemiarthroplasties were revised to THA in 28 patients using the cement in cement technique. All had an Exeter stem inserted at the time of revision. Clinical and operative data were collected prospectively. Clinical evaluation was by the Charnley, Harris and Oxford hip scores and radiographs were analysed post-operatively and at latest follow up.

The mean age at time of hemiarthroplasty revision was 80 (35 to 93) years. The reason for revision was acetabular erosion in 12 (43%), recurrent dislocation in 8 (29%), aseptic loosening in 4 (14%), periprosthetic fracture in 2 (7%) and infection in 2 (7%) patients. No patient has been lost to follow up.

3 patients died within 3 months of surgery. The mean follow up of the remainder was 50 (16 to 119) months. Survivorship with revision of the femoral stem for aseptic loosening as the endpoint was 100%. 3 cases (11%) have since undergone further revision, 1 for recurrent dislocation, 1 for infection, and 1 for periprosthetic fracture.

The cement in cement technique can be successfully applied to revision of hip hemiarthroplasty to THA. It has a number of advantages in this elderly population including minimizing bone loss, blood loss and operative time.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 45 - 45
1 Jan 2011
Williams D Howell J Hubble M Timperley A Gie G
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Survivorship of the standard Exeter Universal cemented stem with revision of the femoral component for aseptic loosening as the endpoint has been reported as 100% at 12 years. A version for use in smaller femora, the Exeter 35.5 mm stem, was introduced in 1988. Although also a collarless polished taper, the stem is slimmer and 25 mm shorter than a standard stem.

Between August 1988 and August 2003 192 primary hip arthroplasties were performed in 165 patients using the Exeter 35.5 mm stem. Clinical and operative data were collected prospectively. Clinical evaluation was by the Charnley, Harris and Oxford hip scores and radiographs were analysed post-operatively and at latest follow up.

The mean age at time of operation was 53 (18 to 86) years with 73 patients under the age of 50 years. The diagnosis was osteoarthritis 91, hip dysplasia in 77, inflammatory arthritis in 18, septic arthritis of the hip in 3, secondary to Perthes disease in 2 and avascular necrosis of the hip in 1 patient. The fate of every implant is known.

At a median follow-up of 8 (5 to 19) years survivorship with revision of the femoral stem for aseptic loosening as the endpoint was 100%. 15 cases (7.8%) underwent further surgery – 11 for acetabular revision, 1 for stem fracture and 3 others.

Although smaller than a standard Exeter Universal polished tapered cemented stem, with a shorter, slimmer taper, the performance of the Exeter 35.5 mm stem was equally good even in this young, diverse group of patients.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 294 - 294
1 May 2009
Crawford R Lee A Smith B Timperley A
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This presentation introduces a new tool to be used in the cementing of acetabular components in total hip arthroplasty, the ‘Rim Cutter’. The Rim Cutter is designed to cut a ledge in the rim of the acetabulum into which a flanged cup can be cemented. The flange is trimmed such that it fits precisely into the ledge cut in the acetabulum. We present the in vitro pilot study of the effect of using this tool on the intra-acetabular cement mantle pressure during cup insertion and also the effect on the depth of cement penetration as the cup is inserted. A significant improvement in both cement pressure and cement penetration over conventional flanged and unflanged cups is noted. Improved cement penetration around the rim of the acetabulum in THR has implications for reducing the rate of aseptic loosening. The pilot study also suggests other beneficial features of using the rim cutter such as improved cup centralisation, control of orientation and the prevention of the cup ‘bottoming out’. Further in vivo studies are required to better assess its efficacy.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 91 - 91
1 Mar 2009
Acharya A Timperley A Lee C
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Vast amount of literature is available on mechanical properties of PMMA, but not about the composite specimens of old and new cement. This is important, as in cement revision has become established technique with good clinical results. Originally Greenwald and later Li described properties of such specimens. However in these studies the old samples were only few days old, unlike clinical situation, where the old cement is a few years old.

We therefore decided to test short-term mechanical properties of composite specimens and compare these with new uniform specimens. We choose specimens of cement 3–17 years old (median 11.8) for the manufacturing of the composite specimens.

Material and Methods: Uniform and composite specimens were fabricated and were tested for bending, tensile and shear strength. Beam shaped specimens were fabricated for bending and tensile tests, cylindrical for shear. Seventeen beams and eight cylindrical specimens fabricated earlier (1988–2002) using the same moulds were available to form composite specimens. Old specimens were placed into the moulds and new cement was injected next to these. Specimens were allowed to polymerize at room temperature for 30 minutes and stored in saline at 37 °C for 6 weeks before testing. Specimens were tested in Lloyds EZ 20 machine with customized jig so that the junction was subjected to bending, tensile or shear force.

Results: Bending tests: The load and bending stress for new specimen was 80N and 47MPa as compared with 72N and 38MPa for composite specimens. 4 composite specimens failed though old cement, 3 through the junction and 1 through the new cement. There was no statistical difference in maximum load between uniform and composite specimens (p=.29). However there was a difference in the stress between uniform and composite specimens.

Tensile tests: The load and tensile stress for new specimen was 916N and 29MPa as compared with 795N and 24MPa for composite specimens. 7 composites failed through old cement, 1 through new cement and 1 at junction. There was difference in the load and stress of uniform specimens as compared with composite specimens.

Shear tests: The load and shear stress for new specimen was 2718N and 35MPa as compared with 2055N and 26MPa for composite specimens. There was significant difference in load as well as stress in uniform specimens as compared with composite specimens.

Discussion: This study demonstrates that composite specimens fail at 89.6% of bending load, 77.2% of tensile and 74.6% of shear load as compared with uniform new cement specimens. They have 81.4% of bending stress, 74.9% of tensile stress and 73.3% of shear stress at failure as compared with uniform specimens. Of more importance is the fact that only four of these composite specimens (23.5%) failed at the junction and the rest thirteen failed either through old cement (64.7%) or through new cement (11.8%).


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 545 - 546
1 Aug 2008
Acharya AD Timperley A Lee AJC
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Introduction: Scant amount of information is available on mechanical properties of composite specimens of old and new cement. In previous studies evaluating this, old samples were only few days old, unlike clinical situation, where the old cement is a few years old.

We evaluated short-term mechanical properties of composite specimens and compared these with new uniform specimens.

Material and Methods: Uniform and composite specimens were fabricated and were tested for bending, tensile and shear strength. Seventeen beams and eight cylindrical specimens fabricated earlier (median age 11.8 years) using same moulds were available to form composite specimens. Specimens were stored in saline at 37 °C for 6 weeks before testing.

Results: Bending tests: Load and bending stress for new specimen was 82.9N and 49.5MPa as compared with 74.3N and 40.3MPa for composite specimens. 4 composite specimens failed though old cement, 3 through junction and 1 through new cement. There was no statistical difference in maximum load (p, 0.3) or stress (P, 0.06) between uniform and composite specimens.

Tensile tests: Load and tensile stress for new specimen was 941.5N and 29.5MPa as compared with 726.9N and 22.1MPa. There was difference in the load and stress of uniform specimens as compared with composite specimens.

Shear tests: Load and shear stress for new specimen was 2692.9N and 34.5MPa as compared with 2009.9N and 25.3MPa. There was significant difference in load as well as stress in uniform specimens as compared with composite specimens.

Discussion: This study demonstrates that composite specimens fail at 89.6% of bending load, 77.2% of tensile and 74.6% of shear load as compared with uniform new cement specimens. Of more importance is the fact that only four of these composite specimens (23.5%) failed at the junction and the rest thirteen failed either through old cement (64.7%) or through new cement (11.8%).


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 297 - 298
1 Jul 2008
Blake S Hubble M Howell J Timperley A Gie G
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Introduction: Removal of all foreign material is the normal practice at the time of revision arthroplasty for sepsis. However, removal of well fixed bone cement is time consuming, can result in significant bone stock loss and increases the risk of femoral shaft perforation or fracture. We report our results of 2 stage revision hip arthroplasty with retention of a well fixed femoral cement mantle.

Methods: If the femoral cement mantle demonstrated good osseo-integration at first stage it was left in-situ. Following Girdlestone excision arthroplasty (GEA), patients received local and systemic antibiotics and underwent reconstruction at a second stage. At the second stage the femoral component was cemented into the old mantle.

Results: 16 patients (M:F 5:11) had at least 3 years follow up (mean 80 months, range 43 to 91). 1 patient died of an unrelated cause at 53 months. Recurrence of infection was not suspected in this case. The mean time to first stage revision was 57 months (3 to 155). The mean time between first and second stages was 9 months (1 to 35). Organisms were identified in 14 (87.5%) cases (5 Staphylococcus Aureus, 4 Group-B Streptococcus, 2 Coagulase negative Staphylococcus, 2 Enterococcus Faecalis, 1 Escheria Coli). At second stage 5 (31.2%) acetabula were uncemented and 11 (68.8%) were cemented. There were 2 complications, 1 patient dislocated 41 days post-operatively and a second patient required an acetabular revision at 44 days for sudden loss of fixation. No evidence of infection was found at re-revision. Currently no patients are suspected of having a recurrence of infection.

Discussion: In-cement revision of the femoral component following GEA for sepsis is not associated with a higher rate of recurrence of infection. Advantages include a shorter operating time, reduced loss of bone stock, improved component fixation and a technically easier second stage procedure.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 318 - 318
1 Jul 2008
Carrington N Sierra R Gie G Timperley A Hubble M Ling R Howell J
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Introduction: We describe an update of our experience with the implantation of the first 325 Exeter Universal hips. The fate of every implant was known.

Methods: This is a review of the prospective data collected from the first 325 Exeter Universal stems (309 patients) inserted between March 1988 and February 1990. The procedures were undertaken by surgeons of widely differing experience. Clinical and radiological review was performed at a mean of 15.4 years.

Results: At last review 185 patients had died (192 hips). 104 hips remain in-situ. Survivorship at 17 years with revision for femoral component aseptic loosening was 100% (95% CI 97 to 100), with revision for acetabular component aseptic loosening was 92.85% (95% CI 87.0 to 96.2) and with any re-operation as the endpoint was 83.99% (95% CI 77.1 to 90.27). 12 patients (12 hips) were not able to attend for review due to infirmity or emigration, and scores were obtained by phone (x-rays were obtained in 4 patients). Mean D’Aubigné and Postel scores (Charnley modification) at review were 5.4 for pain and 4.5 for function. The mean Oxford score was 21.46 +/− 9.52 and the mean Harris score 73.35 +/− 17.32. On radiological review there were no femoral component failures. Three sockets (2.9%) were loose as demonstrated by migration or change in orientation (two patients were asymptomatic) and 5 sockets (4.8%) had radiolucent lines in all 3 zones but no migration. There are two patients awaiting socket revision.

Discussion: The high rate of clinical and radiological success of the Exeter Universal stem seen at 12 years is sustained at 17 years. Further cup failures have occurred but overall survivorship remains good. With the favourable long-term behaviour of the original Exeter stem, we feel optimistic that good function of the Universal stem will continue through the third decade.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 74 - 74
1 Mar 2006
Charity J Gie G Timperley A Ling R
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Introduction & Aims: To study the survivorship and subsidence patterns of the first 433 Exeter polished, totally collarless, double tapered, cemented stems that were inserted between November of 1970 and the end of 1975 by 16 different surgeons (13 of them in the training grades) utilising first generation cementing techniques.

Method: A survivorship study up to the 33rd year of follow-up, using the contingency table method, was performed for all 433 hips, the end-point being revision for aseptic stem loosening. Stem subsidence in relation to the cement and the bone was measured in all survivors by a single observer on digitised films (magnified 200%) using the Orthochart™ software. Stem subsidence, the grade of cementing, ‘calcar’ resorption, visible cement fractures, focal lysis and radiolucent lines at the interfaces were assessed.

Results: Of the 433 hips, 21 were revisions of previously failed hips. 21.7% of patients have had a re-operation of some sort including 3.69% for stem fracture, 3.46% for neck fracture (all from a group of 95 stems with excessively machined necks), 9% for aseptic cup loosening, 3.46% for aseptic stem loosening, 1.84% for infection and 0.23% for recurrent dislocation). For the overall series, with revision for aseptic stem loosening as the end-point, the survivorship is 91.42% (95%CI: 70.82 to 100%). When all cases lost to follow-up (28 hips) are regarded as failures, survivorship is 82.9% (95%CI: 58.37 to 100%).

The average age at operation of the survivors was 55.7 years. No significant radiological subsidence between the cement and bone was found. Mean subsidence between the stem and the cement was 2.15mm, most occurring in the first 5 years and in all but 1 being less than 4. The maximum was 18mm (grade D cementing). Cementing grades were B in 65%, C in 27%, D in 8%. Resorption of the neck (13%) was associated with excessive socket wear or cement left over the cut surface of the neck (the ‘pseudocollar’). Visible cement fractures were found in 14%, none associated with focal lysis, which was seen in 11%.

Conclusions: Although 21.7% of patients in this series of the first 433 Exeter hips to be inserted in Exeter needed a re-operation of some sort, the stem rarely required surgery for aseptic loosening and was associated with benign long-term X-Ray appearances in spite of 1st generation cementing.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 68 - 68
1 Mar 2006
Lamberton T Charity J Kenny P Timperley A Gie G
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Introduction: Impaction bone grafting in conjunction with a cemented polished double-taper stem as a technique for revision of the femoral component was introduced in 1987 at our institution.

Methods: As at January 2000, 540 cases in 487 patients had been performed by multiple surgeons. All procedures have been studied prospectively, and there are no patients lost to follow-up. We present the survivorship and outcome data for these patients.

Results: Survivorship at 15 years is 90.6 percent (95 percent confidence interval: 88–93 percent).

406 hips in 365 patients remain under active follow up, with 122 patients (134 hips) deceased.

Averaged clinical scores taken pre-operatively, 2 years post-operatively, and at latest follow-up show marked and sustained improvement: Charnley Pain 2.7, 5.5, 5.3; Charnley Function 2.1, 4.1, 3.6; Charnley Range of Motion 4.0, 5.4, 5.3; Harris Pain 19, 38, 36; Harris Function 18, 32, 28; and Oxford Hip Score 41, 22, 25.

There have been 45 failures (8.3 percent) at an average 7.6 year follow up (range 2.6 – 15.3 years). Technical error contributed to 13 of the 24 non-infective complications, but with improved technique plus the addition of long stemmed impaction grafting, there have been no technical errors since 1996.

Conclusion: Our results show that revision of the femoral component with impaction bone grafting is a reliable and durable technique with an acceptably low complication rate with excellent survivorship at 15 years.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 27 - 27
1 Mar 2006
Hubble M Patten A Duncan W Howell J Timperley A Gie G
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Retention of well fixed bone cement at the time of a revision THA is an attractive proposition, as its removal can be difficult, time consuming and may result in extensive bone stock loss or fracture. Previously reported poor results of cemented revision THA, however, have tended to discourage Surgeons from performing “cement in cement” revisions, and this technique is not in widespread use.

Since 1989, we have performed a cement within cement femoral stem revision on 354 occasions. The indications for in cement revision included facilitating acetabular revision, replacement of a monoblock stem with a damaged or incompatible head, revision of hemiarthroplasty to THA, component malposition and broken stem. Cement in cement revision was only performed in the presence of well fixed cement with an intact bone-cement interface. An Exeter polished tapered stem was cemented into the existing cement mantle on each occasion.

Follow up of 5 years or longer is available for 175 cases, and over 8 years in 41. On no occasion has a cement in cement femoral stem had to be re-revised during this time for subsequent aseptic loosening. Advantages include preservation of bone stock, reduced operating time, improved acetabular exposure and early post operative full weight bearing mobilisation. This technique has not been used for 1 stage revision of infection.

This experience has encouraged the refinement of this technique, including the development of a new short stem designed specifically for cement within cement revisions. This stem is designed to fit into an existing well fixed cement mantle of most designs of cemented femoral component or hemi-arthroplasty, with only limited preparation of the proximal mantle required. The new stem greatly simplifies cement in cement revision and minimises the risk of distal shaft perforation or fracture, which is otherwise a potential hazard when reaming out distal cement to accommodate a longer prosthesis.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 361 - 361
1 Sep 2005
Charity J Gie G Hoe F Timperley A Ling R
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Introduction and Aims: To study the survivorship and subsidence patterns of the first 433 Exeter polished, totally collarless, double tapered, cemented stems that were inserted between November 1970 and the end of 1975 by 16 different surgeons (13 of them in the training grades) utilising first generation cementing techniques.

Method: A survivorship study up to the 33rd year of follow-up, using the contingency table method, was performed for all 433 hips, the end-point being revision for aseptic stem loosening (including also a ‘worst case’ scenario). Stem subsidence in relation to the cement and the bone was measured in all survivors by a single observer on digitised films (magnified 200%) using the Orthochart™ software. Repeated measurements allowed the analysis of intra-observer errors. Stem subsidence, the grade of cementing, ‘calcar’ resorption, visible cement fractures, focal lysis and radiolucent lines at the interfaces were assessed.

Results: Of the 433 hips, 21 were revisions of previously failed hips. 21.7% of patients have had a re-operation of some sort, including 3.69% for stem fracture, 3.46% for neck fracture (all from a group of 95 stems with excessively machined necks), 9% for aseptic cup loosening, 3.46% for aseptic stem loosening, 1.84% for infection and 0.23% for recurrent dislocation). For the overall series, with revision for aseptic stem loosening as the end-point, the survivorship is 91.42% (95%CI: 70.82 to 100%). When all cases lost to follow-up (28 hips) are regarded as failures, survivorship is 82.9% (95%CI: 58.37 to 100%).

The average age at operation of the survivors was 57.6 years. No significant radiological subsidence between the cement and bone was found. Mean subsidence between the stem and the cement was 2.15mm, most occurring in the first five years and in all but one being less than four. The maximum was 18mm (grade D cementing). Cementing grades were B in 65%, C in 27%, D in 8%. Resorption of the neck (13%) was associated with excessive socket wear or cement left over the cut surface of the neck (the ‘pseudocollar’). Visible cement fractures were found in 14%, none associated with focal lysis, which was seen in 11%.

Conclusion: Although 21.7% of patients in this series of the first 433 Exeter hips to be inserted in Exeter needed a re-operation of some sort, the stem rarely required surgery for aseptic loosening and was associated with benign long-term x-ray appearances in spite of 1st generation cementing.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 357 - 357
1 Sep 2005
Lamberton T Charity J Kenny P Timperley A Gie G
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Introduction and Aims: Impaction bone grafting in conjunction with a cemented polished double-taper stem as a technique for revision of the femoral component was introduced in 1987 at our institution. The aim of this study is to report on the outcome, survivorship, complications and radiological analysis of the first consecutive 540 cases performed in Exeter.

Method: As at January 2000, 540 cases in 487 patients had been performed by multiple surgeons. All procedures have been studied prospectively, and there are no patients lost to follow-up. We present the survivorship and outcome data for these patients.

Radiological analysis of the pre-operative, immediate post-operative and most recent follow-up radiographs was also performed. This included evaluation of the cement mantle and impacted allograft, stem subsidence within the cement mantle, presence of cortical healing and graft trabeculation on the follow-up radiographs, as well as appearance of radiolucencies and graft resorption.

Results: Survivorship at 15 years is 90.6 percent (95 percent confidence interval: 88–93 percent). Four hundred and six hips in 365 patients remain under active follow-up, with 122 patients (134 hips) deceased. Averaged clinical scores taken pre-operatively, two years post-operatively, and at latest follow-up, show marked and sustained improvement: Charnley Pain 2.7, 5.5, 5.3; Charnley Function 2.1, 4.1, 3.6; Charnley Range of Motion 4.0, 5.4, 5.3; Harris Pain 19, 38, 36; Harris Function 18, 32, 28; and Oxford Hip Score 41, 22, 25.

There have been 45 failures (8.3 percent) at an average 7.6-year follow-up (range 2.6–15.3 years). Technical error contributed to 13 of the 24 non-infective complications, but with improved technique plus the addition of long stemmed impaction grafting, there have been no technical errors since 1996.

Conclusion: Our results show that revision of the femoral component with impaction bone grafting is a reliable and durable technique with an acceptably low complication rate with excellent survivorship at 15 years.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 41 - 42
1 Mar 2005
Charity JAF Gie G Hoe F Timperley A Ling R
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Introduction and aims: To study the survivorship and subsidence patterns of the first 433 Exeter stems inserted between 1970 and 1975 by 16 different surgeons utilising first generation cementing techniques.

Method: A survivorship study up to the 33rd year of follow-up was performed, the end-point being revision for aseptic stem loosening. Stem subsidence was measured in all survivors, as well as assessing the grade of cementing, ‘calcar’ resorption, visible cement fractures, focal lysis and radiolucent lines at the interfaces.

Results: Of the 433 hips, 21 were revisions of previously failed hips. 21.7% of patients have had a re-operation of some sort including 3.69% for stem fracture, 3.46% for neck fracture (all from a group of 95 stems with excessively machined necks), 9% for aseptic cup loosening, 3.46% for aseptic stem loosening, 1.84% for infection and 0.23% for recurrent dislocation). For the overall series, with revision for aseptic stem loosening as the end-point, the survivorship is 91.42% (95%CI: 70.82 to 100%). The average age at operation of the survivors was 57.6 years. No significant bone-cement subsidence was found. Mean stem-cement subsidence was 2.15mm, most occurring in the first 5 years and in all but 1 being less than 4mm. Cementing grades were B in 65%, C in 27%, D in 8%. Resorption of the neck (13%) was associated with excessive socket wear or cement left over the cut surface of the neck (the ‘pseudocollar’). Visible cement fractures were found in 14%, none associated with focal lysis, which was seen in 11%.

Conclusions: Although 21.7% of patients in this series of the first 433 Exeter hips to be inserted in Exeter needed a re-operation of some sort, the stem rarely required surgery for aseptic loosening and was associated with benign long-term X-Ray appearances in spite of 1st generation cementing.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 32 - 32
1 Mar 2005
Lamberton T Hubble M Kenny P Timperley A Gie G
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A comparison of the clinical status and outcome of a group of patients treated with tw-stage revision using either excision arthroplasty or an articulating spacer (the Kiwi Prostalac) as the first stage is presented.

Clinical scores were obtained before revision, after the first stage, and after the second stage revision, along with the outcome of the success of the revision procedure in terms of eradication of the infection, from the two study groups. Seven patients received excision arthroplasty and eight were treated with the Kiwi Prostalac spacer, at the treating surgeon’s discretion.

A comparison of the clinical status of the two groups will be presented at the varying stages of treatment, along with hospitalisation duration, and morbidity and ultimate outcome.

Our results demonstrate that two-stage revision with an antibiotic cement-coated THJR prosthesis (The Kiwi Prostalac) is an effective and safe method of managing deep peri-prosthetic infection around a THJR with significant advantages to the patient.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 28 - 29
1 Mar 2005
Lamberton T Charity J Kenny P Timperley A Gie G
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Impaction bone grafting in conjunction with a cemented polished double-taper stem as a technique for revision of the femoral component was introduced in 1987 at our institution.

As at January 2000, 540 cases in 487 patients had been performed by multiple surgeons. All procedures have been studied prospectively, and there are no patients lost to follow-up. We present the survivorship and outcome data for these patients.

Survivorship at 15 years is 90.6 percent (95 percent confidence interval:88–93 percent). Four hundred and six hips in 365 patients remain under active follow up, with 122 patients (134 hips) deceased.

Averaged clinical scores taken preoperatively, 2 years postoperatively and at latest follow up showed marked and sustained improvement: Charnley Pain 2.7, 5.5, 5.3; Charnley Function 2.1, 4.1, 3.6; Charnley Range of Motion 4.0, 5.4, 5.3; Harris Pain 19, 38, 36; Harris Function 18, 32, 28; and Oxford Hip Score 41, 22, 25. There have been 45 failures (8.3 percent) at an average 7.6 year follow up (range 2.6–15.3 years). Technical error contributed to 13 of the 24 non-infective complications, but with improved technique plus the addition of long stemmed impaction grafting, there have been no technical errors since 1996.

Our results show that revision of the femoral component with impaction bone grafting is a reliable and durable technique with an acceptably low complication rate with excellent survivorship at 15 years.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 465 - 465
1 Apr 2004
Halliday B Gie G English H Timperley A Ling R
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Introduction We report the results of cancellous femoral impaction grafting with cement in revision hip arthroplasty in all patients from the above centre, who had their surgery more than five years previously.

Methods Up to December 1994, 226 hips underwent femoral impaction grafting in 207 patients. No deaths were attributable to the revision surgery. Thirty-three patients with 35 functioning hips died with less than five years follow-up. Only one patient was lost to follow-up. All other patients have had clinical review by two of the authors (BH and HE) and a combined panel undertook radiological review.

Results Two hips (one percent) became infected at the time of their revision surgery. Twelve stems underwent a further surgical procedure for aseptic failure; 10 for treatment of fracture and two for mechanical loosening in the absence of fracture. Survivorship with any femoral re-operation for any cause as the end point was 90.5% (confidence interval 82 to 98% (Peto equation)) at 10 to 11 years. Using femoral re-operation for symptomatic aseptic mechanical loosening as the endpoint the survivorship was 99.1% (CI= 96–100) at the same follow-up. The technique used in our centre has been modified since this series with an increased use of longer stems with impacted allograft. The technique used in Exeter has evolved and there has been an increased awareness of the fundamental importance of gaining stability of the implant within the graft at the time of surgery.

Conclusion These results provide evidence of a successful technique in the intermediate to long term.

In relation to the conduct of this study, one or more the authors have received, or are likely to receive direct material benefits.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 263 - 263
1 Mar 2004
Timperley A Halliday B English H Gie G Ling R
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Aims: This study reports the results of all patients from our centre who underwent femoral impaction grafting more then five years previously. As a consequence of our experience our technique has been modified and the indications for impaction grafting have become clearer. Methods: 226 hips underwent femoral impaction grafting in 207 patients. No deaths were attributable to the revision surgery. 33 patients with 35 functioning hips died with less than 5 years follow up. Only one patient was lost to follow-up. There were two (1%) acute infections. Twelve stems underwent a further surgical procedure for aseptic failure – 10 for treatment of femoral fracture and 2 for mechanical loosening in the absence of fracture. Results: Survivorship with any femoral re-operation for any cause as the end point is 90.5% (Confidence Interval 82–98%) at 10–11 years. Using femoral re-operation for symptomatic aseptic mechanical loosening as the endpoint the survivorship was 99.1% (Confidence Interval 96–100%) at the same follow-up. Conclusions: As a consequence of our experience in this series our technique has been modified with an increased use of longer stems with impacted allograft. Long stems are indicated when the host bone around a short stem is significantly compromised, in cases of severe bone stock loss, or when a fracture occurs.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 159 - 159
1 Feb 2003
English H Timperley A Dunlop D Gie G
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To establish the efficacy of femoral impaction grafting in femoral reconstruction following sepsis, we identified and reviewed all cases of two stage hip revision for sepsis in which femoral impaction grafting was used in the second stage, performed in Exeter from 1989 until the end of 1998. All patients underwent a Girdlestone excisional arthroplasty, were prescribed local and systemic antibiotic treatment, and then subsequently underwent surgical reconstruction, using femoral impaction grafting.

These 53 cases represent a subgroup of our patients who had received a two-stage revision for infection during that period. The other patients did not require femoral grafting. 4 patients died within 24 months of surgery.

4 patients became reinfected (7.5%), and 1 patient underwent stem revision for a fracture below the tip of the stem at 10 months, leaving 44 patients with an average of 53 months follow up (range 24 to 122 months). These 44 patients all demonstrated improved clinical scores and satisfactory radiological outcomes.

Our clinical results reveal post-operative scores approaching those for primary arthroplasty. Our intermediate term results justify the use of fresh frozen allograft bone in the second stage of revisional hip surgery for its low incidence of reinfection and loosening, and potential to improve bone stock.


The Journal of Bone & Joint Surgery British Volume
Vol. 75-B, Issue 5 | Pages 693 - 696
1 Sep 1993
Ling R Timperley A Linder L

We report the histology of a femur retrieved 3.5 years after a cemented revision of a hip replacement in which impaction allografting had been used to fill two large cortical defects. The allograft chips had largely been replaced by viable cortical bone, and the interface between cement and tissue resembled that seen after primary cemented arthroplasty.


The Journal of Bone & Joint Surgery British Volume
Vol. 75-B, Issue 1 | Pages 14 - 21
1 Jan 1993
Gie G Linder L Ling R Simon J Slooff T Timperley A

We report the results of using impacted cancellous allografts and cement for fixation of the femoral component when revision arthroplasty is required in the face of lost bone stock. In 56 hips reviewed after 18 to 49 months there were few complications and a majority of satisfactory results with evidence of incorporation of the graft. Further study and review are necessary, but the use of the method appears to be justified.