Meshing increased the gliding resistance by approximately 20% and 30% in phase 2 and 3 respectively. Edge tying decreased the gliding resistance by 27% below that of normal pulley
No animal was killed for the study.
The treatment of bony defects of the tibia at the time of revision total knee replacement is controversial. The place of compacted morsellised bone graft is becoming established, particularly in contained defects. It has previously been shown that the initial stability of impaction-grafted trays in the contained defects is equivalent to that of an uncemented primary knee replacement. However, there is little biomechanical evidence on which to base a decision in the treatment of uncontained defects. We undertook a laboratory-based biomechanical study comparing three methods of graft containment in segmental medial tibial defects and compared them with the use of a modular metal augment to bypass the defect. Using resin models of the proximal tibia with medial defects representing either 46% or 65% of the medial cortical rim, repair of the defect was accomplished using mesh, cement or a novel bag technique, after which impaction bone grafting was used to fill the contained defects and a tibial component was cemented in place. As a control, a cemented tibial component with modular metal augments was used in identical defects. All specimens were submitted to cyclical mechanical loading, during which cyclical and permanent tray displacement were determined. The results showed satisfactory stability with all the techniques except the bone bag method. Using metal augments gave the highest initial stability, but obviously lacked any potential for bone restoration.
Wear of metal-on-metal bearings causes elevated levels of cobalt and chromium in blood and body fluids. Metal-on-metal bearings have two distinct wear phases. In the early phase, the wear rate is high. Later, it decreases and the bearing enters a steady-state phase. It is expected that as the wear rates decline, the level of cobalt detected in plasma will also decrease. We studied the baseline and exercise-related cobalt rise in 21 patients (13 men and eight women) with a mean age of 54 years (38 to 80) who had undergone successful hip resurfacing at a mean of 44 months (10 to 96) earlier. Our results showed that circulating baseline cobalt levels were not significantly correlated with the time since implantation (r = 0.08, p = 0.650). By contrast, the exercise-related cobalt rise was directly correlated with the inclination angle of the acetabular component (r = 0.47, p = 0.032) and inversely correlated with the time since implantation (r = −0.5, p = 0.020). Inclination of the acetabular component should be kept less than 40° to decrease the production of wear debris.
The Ilizarov technique of distraction osteogenesis is becoming a more common way of treating complicated fractures. It has been shown that shear IFMs will delay bone healing whilst axial IFMs are beneficial to the bone healing. Therefore to measure IFMs in conditions of mobility will provide critical information for research and clinic diagnosis. Such data are not provided by static measurements. Traditionally the IFMs were measured by implanting transducers to the bone or using radiological methods. However, these methods are not suitable for either clinic utilization or measurement of IFMS when patients are doing movements which simulate their daily activities. We have designed a dynamic IFMs measuring device. It includes a displacement transducer array, which is connected to the Ilizarov wires. This transducer array consists of 6 parallel linear displacement transducers, each of which is attached to the fixing wires of the fix-ator. This arrangement of transducers can fit into the configuration of Stewart Platform. The Reverse Stewart Platform algorithm was employed to calculate IFMs. Without measuring the bone fracture segments directly, the two segments were fitted into two planes virtually. By studying the relative movements of the two virtual planes, the algorithm transfers the relative movement to relative axial &
shear translation, and relative bending &
torsion rotation, between the two fracture segments. Wireless interface was used to transfer the displacement readings from the transducer array to the computer. This setup allows patient perform activities which represent their routine activities. In laboratory studies, we found the error of this system to be related to the IFMs. For small movements around 100 micron, the absolute error was 50 micron, whereas for larger movements around 1 mm, the error was within 0.22mm. This real time monitoring method will allow kinematical and kinetic studies on fracture patients treated with Ilizarov frame. Measurements obtained using this novel device will reflect the natural pattern of IFMs during the patients’ daily life. Since use of the device requires no additional pin, wire or operative procedure, it will be clinically applicable. The accurate real-time IFMs measurements will help elucidate the complex interplay between movement and bone formation.
The Trent arthroplasty register reported that results of Hip arthroplasty in general setup were less than that reported from specialist centres by 5%. This independent prospective study tests the hypothesis that results of Birmingham Hip Resurfacing (BHR) arthroplasty from pioneering centres would not accurately represent the outcome of hip resurfacing when performed in general setup. All patients were prospectively followed for at least five years at Oswestry Hip outcome centre. The surgeons carrying out the operation prospectively provided surgical details and thereafter patients were followed using Oswestry hip questionnaire (OSHIP) at fixed intervals. Survival was assessed by Kaplan-Meier method. Results were compared to the published results of BHR from specialist centres. There were 679 patients, and 58 surgeons in the study. Mean age at operation was 51 years and mean follow up was 5.63 years. The predominant preopera-tive diagnosis was Osteoarthritis. Mean OSHIP score was 89.5. There were 29 (4.2%) failures mostly due to fracture neck of femur (34%). Out of 14 failures in the first year, 9 (64%) were due to fracture neck of femur. The Kaplan-Meier survival up to eight years is 95.354% in the current study. Compared to the published results, there were 2 to 19 times high failure rate which is significantly higher (p=0.001) than the published studies. Most of the early failures were due to fracture neck of femur in the first year. Hence we prove our hypothesis, as the results of BHR from specialist centres do not accurately reflect on the outcome in general setup. The discrepancy in the results is mostly due to fracture neck of femur in the early postoperative time. The results of this study will enhance awareness of the early trend in failures. Appropriate patient selection and meticulous surgical technique will help avoid this complication in the general setup, where most of the patients get benefited from BHR arthroplasty.
In-vitro studies have shown that wear rates of the metal on metal (MOM) bearing hip prostheses decline once the bearing runs-in and the bearing subsequently enters a steady state wear phase. Baseline cobalt levels are thus expected to decline with time in patients. Several clinical studies have not found such a decline. Baseline cobalt levels are hence limited in their capacity to provide information on the wear performance of the bearing couple. We have demonstrated in a previous study that exercise causes a rise in plasma metal ion levels in patients with MOM bearing hip replacement. Would the exercise related cobalt rise be more sensitive to detect change in wear behaviour of the bearing couple? We tested the alternate hypothesis that exercise related rise in the plasma cobalt levels will correlate inversely with the duration of MOM implantation. Sixteen patients with three different well functioning MOM bearing hip replacement [two types of resurfacing (BHR, Cormet) and Metasul] were included into the study. Patients were divided in to two groups based on time since implantation, an early group of mean 18 months and a late group of mean 57 months. Plasma levels of cobalt were measured before (baseline) and after 1 hour of maximal exercise (peak). The difference between baseline and peak for each patient provided the exercise related cobalt rise. A significant increase in plasma cobalt levels of 13% was noticed after the exercise (p <
0.005). Baseline Cobalt levels in the late group (53nmol/l) were higher than early group (44nmol/l) but the difference was not significant (p=0.45). However, the mean exercise related Cobalt rise levels was lower in late group (3.5nmol/l) than the early group (6.5nmol/l). This lower rise in cobalt level in the late group precisely reflects on the steady state wear as seen in in-vitro tests. Baseline cobalt levels are limited in determining the in-vivo performance of the bearing couple. Exercise related rise in cobalt levels can differentiate the running in and steady state wear phases of metal on metal bearings and is thus a more accurate tool of assessing in-vivo wear performance of the bearing couple.
Methotrexate and Cox-2 inhibitors are thought to interfere with bone healing. There have been controversial results published in the literature. The effect of newer antirheumatoids (Leflunomide, Etanercept, Infliximab) has not been studied. The aim of this study was to find the in-vitro effect of methotrexate, newer anti-rheumatoids, steroids and cox-2 inhibitors on Osteoblasts. Osteoblasts were cultured from femoral heads obtained from young otherwise healthy patients undergoing total hip replacement. The cells were cultured using techniques that have been previously described. A computer aided design of experiment was used as a model for setting up the experiment on samples obtained from five patients. Normal therapeutic concentration of the various antirheumatoids was added alone and in combination to the media. The cell growth was estimated after two weeks using spectrophotometric technique using Roche Cell proliferation Kit. Multiple regression analysis was done to estimate the best predictor of the final result. Patient was found to be the most significant factor (p<
0.001) in predicting the ultimate response. Cox-2 inhibitor (Etoricoxib) was found to be the next best predictor (p=0.043). Etoricoxib in fact had a stimulatory effect (R=0.219) on the osteoblast growth, which was accentuated in the presence of other agents that varied amongst different patients. Different patients respond differently to the drugs. None of the antirheumatoids inhibit osteoblast proliferation and differentiation in-vitro. If osteoblastic activity is considered to be the primary factor responsible for bone healing, then an inhibition should not result in patients who are on these drugs.