Abstract
Purpose
To evaluate the efficacy of novel biodegradable MAACP/n-HA composite artificial lamina for the prevention of postlaminectomy adhesions and lamina reconstruction.
Methods
Goats were randomly divided into three groups: an experimental group consisting of twelve goats that underwent cervical 4 laminectomies, followed by MAACP/n-HA composite artificial lamina implantations; a control group of nine goats whose cervical 4 vertebra plate were removed; and a normal group of three goats that did not receive any operations or treatments. On weeks 4, 12 and 24, two goats, two goats, three goats in the test group and two, two, two in the control group were selected using X-ray, CT, MRI and subsequently killed for histological examinations and SEM (scanning electronic microscopY). On week 24, the adhesion level of scar tissue was examined according to Rydell's degree of adhesion criteria. Biomechanical measurements were carried out at week 24 on 3 goats in the test group, 3 in the control group, and 3 in the normal group.
Results
In the experimental group, the artificial lamina refrained from shifting, and no dural adhesion pressure was observed. New goat cervical natural bone formed in the defect and the bony spinal canal had reformed. In contrast, in the control group, fibrous scar tissue filled the defect and the scar tissue continued to exert pressure on the dura.
Conclusions
Artificial lamina could prevent the epidural adhesions surrounding the defect and promote effectively bone tissue repair and new bone formation.
MULTIPLE DISCLOSURES
