Abstract
Biometals like Magnesium (Mg) and Zinc (Zn) are essential for life. Mg/Zn-deficiency has been linked to numerous diseases including cardiovascular, bone, diabetics, neurological and neurodegenerative disorders. Moreover, Mg/Zn-based biomaterials have recently emerged as innovative degradable medical implants, typically for cardiovascular and orthopedic application. We study the pathophysiological role of Mg2+/Zn2+ ion in vascular and bone diseases, as well as metallic Mg/Zn alloys for stent and bone implant applications. We demonstrated some interesting role and mechanism of Mg2+/Zn2+ ion in controlling cellular functions. Also, metallic Mg/Zn-based medical implants exhibited strong potential as stent and bone fixation device. They have sufficient mechanical strength, promotes tissue regeneration, and are fully bioresorbable with minimal toxicity. The beneficial or therapeutic role of biometals Mg/Zn in medicine and biomaterial applications is still not fully explored, our research aims to answer some fundamental questions and to inspire more future studies related to biometals in health.
