PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD

JS Chang; JH Park; HC Shon; JH Kim

doi:10.1302/0301-620X.86BSUPP_II.0860143c

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PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD

JS Chang
JH Park
HC Shon
JH Kim

PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD

Chang J, Park J, Shon H, Kim J. PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD. Orthop Procs. 2004;86-B(SUPP_II):143-144. doi:10.1302/0301-620X.86BSUPP_II.0860143c

Chang, JS, et al. “PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD.” Orthopaedic Proceedings, vol. 86-B, no. SUPP_II, 2004, pp. 143-144., https://doi.org/10.1302/0301-620X.86BSUPP_II.0860143c

Chang, J., Park, J., Shon, H., & Kim, J. (2004). PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD. Orthopaedic Proceedings, 86-B(SUPP_II), 143-144. https://doi.org/10.1302/0301-620X.86BSUPP_II.0860143c

Chang, J., Park, J., Shon, H. and Kim, J. (2004) “PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD.” Orthopaedic Proceedings, 86-B(SUPP_II), pp. 143-144. Available at: https://doi.org/10.1302/0301-620X.86BSUPP_II.0860143c

Chang, JS, JH Park, HC Shon, and JH Kim. “PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD.” Orthopaedic Proceedings 86-B, no. SUPP_II (2004): 143-144. https://doi.org/10.1302/0301-620X.86BSUPP_II.0860143c

Chang J, Park J, Shon H, Kim J. PPARγ2 EXPRESSION IN OSTEONECROSIS OF THE FEMORAL HEAD. Orthop Procs. 2004 Feb 1;86-B(SUPP_II):143-144. https://doi.org/10.1302/0301-620X.86BSUPP_II.0860143c

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Abstract

Introduction: Hyperlipidemia is related to hypercoagulability and hypofibrinolysis, which may cause a tendency to intravascular thrombosis and result in osteonecrosis (ON). Recently PPARs were confirmed to induce adipocyte differentiation, and fatty acids were identified as the transcriptional effectors for PPARs, which may cause the hyperlipidemia and fatty marrow. The aim of this study was to identify whether the adipocytic differentiation was increased in the bone marrow obtained from the femoral head in patients with osteonecrosis.

Materials and Methods: A lipid profile (cholesterol, triglyceride, LDL, and free fatty acid) was performed for patients with osteonecrosis of the femoral head. The PPARγ2 expression was checked as to whether the mesenchymal stem cells differentiate toward adipocytes rather than osteogenic cells. RT-PCRs were completed using the bone marrow stroma cells obtained during THA from 11 patients with osteonecrosis and 9 control patients. As not all of alcoholics and steroid users develop osteonecrosis, genetic differences may relate to susceptibility to the osteonecrosis. Therefore, we determined the polymorphism of the PPARγ2 gene for 34 osteonecrosis patients and 76 controls.

Results: Among 89 cases of osteonecrosis, increased free fatty acid (above 580mg%) was the most frequent finding (40.8%), and triglyceride was the next (29.6%). Cholesterol was increased in only 9.0%. Seven of the osteonecrosis cases (63.6%) and 4 of the control cases (44.4%) expressed PPARγ2. Pro/Ala (C/G) polymorphism was found in seven (20.6%) ON cases and four control cases (5.3%), and Ala/Ala (G/G) polymorphism was found in only 1 case in the control group. The numbers of patients with elevated triglyceride among osteonecrosis were much higher (71.4%) in polymorphism (C/G) than osteonecrosis (21.5%) without polymorphism.

Discussion: In conclusion, hyperlipidemia and higher expression of the PPARγ2 were found in ON, and Pro/Ala PPARγ2 polymorphism was more common in ON.

The abstracts were prepared by Michael A. Mont, M.D. and Lynne C. Jones, Ph.D. Correspondence should be addressed to L. Jones at Good Samaritan Prof. Bldg., Suite 201, 5601 Loch Raven Blvd., Baltimore, MD 21239