The aim of this study was to define the complications and long-term outcome following adolescent mid-shaft clavicular fracture. We retrospectively reviewed a consecutive series of 677 adolescent fractures in 671 patients presenting to our region (age 13 to 17 years) over a ten-year period (2009 to 2019). Long-term patient-reported outcomes (abbreviated version of the Disabilities of the Arm, Shoulder and Hand (QuickDASH) score and EuroQol five-dimension three-level (EQ-5D-3L) quality of life score) were undertaken at a mean of 6.4 years (1.2 to 11.3) following injury in severely displaced mid-shaft fractures (Edinburgh 2B) and angulated mid-shaft fractures (Edinburgh 2A2) at a minimum of one year post-injury. The median patient age was 14.8 years (interquartile range (IQR) 14.0 to 15.7) and 89% were male (n = 594/671).Aims
Methods
Platelet-rich fibrin matrix (PRFM) has been proved to enhance tenocyte proliferation but has mixed results when used during rotator cuff repair. The optimal PRFM preparation protocol should be determined before clinical application. To screen the best PRFM to each individual’s tenocytes effectively, small-diameter culture wells should be used to increase variables. The gelling effect of PRFM will occur when small-diameter culture wells are used. A co-culture device should be designed to avoid this effect. Tenocytes harvested during rotator cuff repair and blood from a healthy volunteer were used. Tenocytes were seeded in 96-, 24-, 12-, and six-well plates and co-culture devices. Appropriate volumes of PRFM, according to the surface area of each culture well, were treated with tenocytes for seven days. The co-culture device was designed to avoid the gelling effect that occurred in the small-diameter culture well. Cell proliferation was analyzed by water soluble tetrazolium-1 (WST-1) bioassay.Objectives
Methods
It is difficult to determine the safe timing
of weight-bearing or reconstructive surgery in patients with Charcot arthropathy
of the foot and ankle. In this study the Doppler spectrum of the
first dorsal metatarsal artery was used to monitor the activity
of the disease activity and served as a guideline for management.
A total of 15 patients (seven men and eight women) with acute diabetic
Charcot arthropathy of the foot and ankle were immobilised in a non-weight-bearing
cast. They were followed at two-week intervals and bilateral Doppler
spectra of the first dorsal metatarsal arteries were obtained using
a 10 MHz linear ultrasound probe. The patients were allowed to start weight-bearing
or undergo surgery after the Doppler spectrum had returned to normal
pattern. The Doppler spectra in the unaffected limbs were triphasic
in pattern, whereas those in limbs with active Charcot arthropathy
showed monophasic forward flow. They returned to normal after a
mean of 13.6Â weeks (6 to 20) of immobilisation. Three patients underwent
pan-talar arthrodesis to correct gross instability and deformity. Doppler spectrum analysis of the foot may reflect the activity
of the disease in patients with Charcot arthropathy, and may be
used as a guide to begin weight-bearing or undergo reconstructive
surgery.
