A substantial body of evidence supports the use of extracorporeal shock wave therapy (ESWT) for fracture non-unions in human medicine. However, the success rate (i.e., radiographic union at six months after ESWT) is only approximately 75%. Detailed knowledge regarding the underlying mechanisms that induce bio-calcification after ESWT is limited. The aim of the present study was to analyse the biological response within mineralized tissue of a new invertebrate model organism, the zebra mussel Dreissena polymorpha, after exposure with extracorporeal shock waves (ESWs). Mussels were exposed to ESWs with positive energy density of 0.4 mJ/mm² or were sham exposed. Detection of newly calcified tissue was performed by concomitantly exposing the mussels to fluorescent markers. Two weeks later, the fluorescence signal intensity of the valves was measured. Mussels exposed to ESWs showed a statistically significantly higher mean fluorescence signal intensity within the shell zone than mussels that were sham exposed. Additional acoustic measurements revealed that the increased mean fluorescence signal intensity within the shell of those mussels that were exposed to ESWs was independent of the size and position of the focal point of the ESWs. These data demonstrate that induction of bio-calcification after ESWT may not be restricted to the region of direct energy transfer of ESWs into calcified tissue. The results of the present study are of relevance for better understanding of the molecular and cellular mechanisms that induce formation of new mineralized tissue after ESWT. Specifically, bio-calcification following ESWT may extend beyond the direct area of treatment.

Objectives

Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts. The PTH counterpart in bone, which is the PTH-related protein (PTHrP), displays osteogenic actions through both its N-terminal PTH-like region and the C-terminal domain.

Proper component alignment is crucial for a successful total hip arthroplasty (THA). Some studies found safe cup orientations and corresponding stem antetorsions based on a defined desired range of motion (ROM) suitable for activities of daily living. These studies either used complex and time consuming 3D simulations or more simple mathematical formulas which cannot be extended to combined motions.

With the method introduced in this work, any arbitrary motion can be applied. The ROM specified as the ROM of the femur relative to the pelvis is transformed into the ROM of the prosthesis neck relative to the cup for each cup orientation. For this transformation, the orientation and design of the stem are considered. The comparison of the neck and cup orientations is done using a 2D mapping of a 3D spherical surface which reduces the complexity of the calculation.

We found that the femoral antetorsion as well as the neutral stem flexion and adduction have an influence on the resulting safe zone. The result is not just a combined anteversion but a combined orientation. For validating the plausibility of the algorithm, the resulting safe zones are compared to literature. Same results can be achieved using the same input data. Using this technique, a patient-specific safe zone based on the ROM can be derived and adjusted to the stem orientation.

Robotic surgical systems reduce the cognitive workload of the surgeon by assisting in guidance and operational tasks. As a result, higher precision and a decreased surgery time are achieved, while human errors are minimised. However, most of robotic systems are expensive, bulky and limited to specific applications.

In this paper a novel semi-automatic robotic system is evaluated, that offers the high accuracies of robotic surgery while remaining small, universally applicable and easy to use. The system is composed of a universally applicable handheld device, called Smart Screwdriver (SSD) and an application specific kinematic chain serving as a tool guide. The guide mechanism is equipped with motion screws. By inserting the SSD into a screw head, the screw is identified automatically and the required number of revolutions is executed to achieve the desired pose of the tool guide.

The usability of the system was evaluated according to IEC 60601-1-6 using pedicle screw implementation as an example. The achieved positioning accuracies of the drill sleeve were comparable to those of fully automatic robotic systems with −0.54 ± 0.93 mm (max: − 2.08 mm) in medial/lateral-direction and 0.17 ± 0.51 mm (max: 1.39 mm) in cranial/caudal- direction in the pedicle isthmus. Additionally, the system is cost-effective, safe, easy to integrate in the surgical workflow and universally applicable to applications in which a static position in one or more DOF is to be adjusted.

For a successful total knee arthroplasty (TKA) and long prosthesis lifespan, correct alignment of the implant components as well as proper soft tissue balancing are of major importance. In order to overcome weaknesses of existing imaging modalities for TKA planning such as radiation exposure and lack of soft tissue visualisation (X-ray and CT) and high cost, long acquisition times and geometric distortion (MRI), it is investigated if ultrasound (US) imaging is a suitable alternative.

Currently, a reconstruction method of the bony knee morphology based on US imaging is developed at our research institute. For capturing the mechanical axis, being crucial for TKA planning, different approaches could be implemented. This work investigates whether a weight-bearing full leg X-ray registered with the local 3D-US knee dataset can be used for this purpose. Also, the impact of incorrect calibration data (i.e. uncalibrated X-rays) on the accuracy of the estimated mechanical axis is investigated.

A 3D-2D projective, feature-based registration algorithm was used to spatially align the 3D US-based model to the 2D X-ray image before transferring the mechanical axis from the X-ray to the model. For validation, a CT-based local model and its projection were used and an initial error in translation and rotation was added. Also, calibration parameters such as the centre ray position and the source-to-image-detector distance were altered. The estimation error of the mechanical axis was less than 1°, the median error lower than 0.1° in the frontal plane. Even if the calibration data is not available, the accuracy remains sufficient for TKA planning. In this study, idealised 2D and 3D image information was used. In the future, this method should be tested using clinical X-ray images and 3D-US data.

Pertrochanteric femoral fractures are common and intramedullary nailing with a proximal femoral nail (PFNA®) is an accepted method for the surgical treatment. Accurate guide wire and subsequent hardware placement in the femoral neck is believed to be essential in order to avoid mechanical failure. Malpositioned implants may lead to rotational or angular malalignment or “cut out” in the femoral neck. Hip and knee arthritis might be a potential long-term consequence. The conventional technique might require multiple guidewire passes, and relies heavily on fluoroscopy.

A computer-assisted surgical planning and navigation system based on 2D-fluoroscopy was developed in-house as an intraoperative guidance system for navigated guide wire placement in the femoral neck and head. To support the image acquisition process, the surgeon is supported by a so-called “zero-dose C-arm navigation” module. This tool enables a virtual radiation-free preview of the X-ray images of the femoral neck and head. The aim of this study was to compare PFNA® insertion using this system to conventional implantation technique. We hypothesised that guide wire and subsequent implant placement using our software decreases radiation exposure to the minimum of two images and reduces the number of drilling attempts. Furthermore, accuracy of implant placement in comparison to the conventional method might be improved and operation time shortened.

We used 24 identical intact left femoral Sawbones® to simulate reduced pertrochanteric femoral fractures. First, we performed placement of the PFNA® into 12 Sawbones using the conventional fluoroscopic technique (group 1). Secondly, we performed placement of the PFNA® into 12 Sawbones guided by the computer-assisted surgical planning software (group 2). In each group, we first performed open and secondly minimal-invasive intramedullary nailing in six sawbones each. For minimal-invasive guide wire placement, a surgical drape imitated soft tissue coverage. Conventional and navigated technique used a C-arm fluoroscope (Siemens IsoC 3D®, Erlangen, Germany) in conventional 2D mode. Guidewire and subsequent blade placement in the femoral neck was evaluated. We documented: 1: the number of fluoroscopic images; 2: the total number of drilling attempts; 3: implant placement accuracy (3.1. Tip apex distance (TAD); 3.2. visible penetrations of the femoral neck and head; 3.3. blade-corticalis bone distance in the anteroposterior and lateral plane) and the 4: operation time.

The number of fluoroscopic single shots taken to achieve an acceptable PFNA®-blade position was reduced significantly with computer-assistance by 71.5% (p<0.001) in the open and by 72,4% (p<0.001) in the minimally invasive technique. In each operation two X-rays for final documentation were taken. The average number of drilling attempts for the computer-guided system was significantly (p<0.05) less than that of the conventional technique in the minimally invasive procedure. The average number of drilling attempts showed no difference between the computer-assisted and conventional techniques in the open procedure. Accuracy of implant placement showed no difference between the computer-assisted and the conventional group. Computer assistance significantly increased the mean operation time for fixation of pertrochanteric femoral fractures with a PFNA® by 79.8% (p<0.001) in the open technique and by 54.4% (p<0.001) in the minimally invasive technique.

Use of our computer-guided system for fixation of pertrochanteric femoral fractures by a PFNA® decreases the number of fluoroscopic single shots and of suboptimal guide wire passes while maintaining blade placement accuracy that is equivalent to the conventional technique. Computer-assisted surgery with our system increases the operation time and has just been tested in non-fractured sawbones. Although these results are promising, additional studies including fractured sawbones and cadaver models with extension of the navigation process to all steps of PFNA® introduction and with the goal of reducing the operation time are indispensable before integration of this navigation system into the clinical workflow.

Consideration of biomechanical aspects during computer assisted orthopaedic surgery (CAOS) is recommendable in order to obtain satisfactory long-term results in total hip arthroplasty (THA). In addition to the absolute value of the hip joint resultant force R the pre- and post-operative orientation of R is an important aspect in the context of the development of a planning module for computer-assisted THA and furthermore for planning of acetabular orientation in periacetabular osteotomy interventions. It is possible to estimate the orientation of hip joint resultant force R for individual patients based on geometrical and anthropometrical parameters. The aim of this study was to examine how far the choice of the mathematical model influences the computational results for the orientation of R in the frontal plane. A further aspect was the comparison of the results with in-vivo data published in the open access OrthoLoad database (www.orthoload.com).

Our comparative study included the 2D-models suggested by Pauwels, Blumentritt and Debrunner as well as the 3D-model suggested by Iglič and three patient datasets from the Orthoload database. As computation of R according to each model relies on standardized X-ray imaging, three anterior-posterior (a.p.) digitally reconstructed radiographs (DRRs) were generated from CT data (x21_x21, x8_x8, x12_x12). The orientation of R was expressed in terms of the angle δ for these three patient individual datasets. The angle δ is defined as the angle between the longitudinal axis and R. The computation results were also compared with in vivo telemetric measurement data from the OrthoLoad database. The following data were used to evaluate R in the frontal plane: the highest load peak of the single leg stance (static conditions) of three patients (EBL, HSR, KWR) respectively in the same manner for planar gait (dynamic conditions) of one patient (KWR). The mean value of the orientation of R under static conditions in single leg stance was calculated in order to get a reference value. For the orientation of R under dynamic conditions δ was calculated by using only the highest peak of three cycles (heel strike to toe off) determined in one single patient (among the three patients involved in the measurements under static conditions) of the database.

The following values of δ were obtained:

Pauwels: 18.26°/20.34°/17.31° (x21_x21/x8_x8/x12_x12) Debrunner: 12.37°/14.30°/12.59° Blumentritt: 5.18°/6.52°/6.14° Iglič: 9.24°/9.01°/9.20°

OrthoLoad database (in-vivo): 28.41°/17.08°/13.32°-static (EBL/HSR/KWR) 16.44°-dynamic (KWR)

The differences in the computational results appear to depend more on the hip model than on the variability of patient-specific geometrical and anthropometrical parameters. The results obtained with in-vivo measurement data are best approximated by using Pauwels' model. The mean values of Pauwels (18.64°), Debrunner (13.09°) and Iglič (9.15°) are a little bit more vertically orientated than the mean value of the static in-vivo results (19.60°). Only Pauwels' model result has a larger angle δ than the in-vivo dynamic result (KWR = 16.44°). By comparing the in-vivo values obtained under dynamic conditions, i.e. gait, (16.44°) with the static in-vivo values of the same patient (13.32°), it could be recognized that the static values are a little bit more vertically orientated than the dynamic result. But both are in the same range as the mathematical models.

The computational biomechanical hip models try to approximate the physiological conditions of the hip joint and the OrthoLoad database represents the physiological reconstructed (artificial) hip joint. Therefore, we think our validation approach is useful for a comparison of the biomechanical computation models.

In contrast, Blumentritt's model outcomes have the largest deviation from the other models as well as from the in-vivo data (static and dynamic conditions). Blumentritt used the weight bearing surface as a reference. He defined it being perpendicular to the longitudinal axis [3]. He postulated that a valid and optimal orientation of R is approximately perpendicular on the weight bearing surface respectively parallel to the longitudinal axis. This approach for validation is questionable because the results show that in the three included and analysed DDR's the orientation is in the mean value 5.95° to the longitudinal axis. It can be concluded that Blumentritt's model assumptions have to be carefully reviewed due to the deviations from in-vivo measurement data.

Among the limitations of our study is the fact that the OrthoLoad database offers only a small number of patient datasets. There is only one dataset for the direct comparison of static (single leg stance) and dynamic (free planar gait) in-vivo measurement data of the same patient included. Furthermore, the individual anatomic geometry data of the patients included in the database are not revealed. Additionally, a source of errors could be an inaccuracy during the data acquisition from the DRR.

Further research seems to be recommendable in the context of implementing a biomechanical hip model in a planning module for computer-assisted THA or periacetabular osteotomy interventions, respectively. Sensitivity analyses and parameter studies for different mathematical models using a multi-body-simulation system are objectives of our ongoing work.

Fluoroscopic guidance is common in interventional pain procedures. In spine surgery, injections are used for differential diagnosis and determination of indication for surgical treatment as well. Fluoroscopy ensures correct needle placement and accurate delivery of the drug. Also, exact documentation of the intervention performed is possible. However, besides the patient, interventional pain physicians, surgeons and other medical staff are chronically exposed to low dose scatter radiation. The long-term adverse consequences of low dose radiation exposure to the medical staff are still unclear. Especially in university hospital settings, where education of trainees is performed, fluoroscopy time and total radiation exposure are significantly higher than in private practice settings. It remains a challenge for university hospitals to reduce the fluoroscopic time while maintaining the quality of education.

Multiple approaches have been made to reduce radiation exposure in fluoroscopy, including the wide spread use of pulsed fluoroscopy, or rarely used techniques like laser guided needle placement systems. The Zero-Dose-C-Arm-Navigation (ZDCAN) allows an optimal positioning of the c-arm without exposure to radiation. For training purposes, relevant anatomical structures can be highlighted for each interventional procedure, so injection needles can be best positioned next to the target area.

The Zero-Dose-C-Arm-Navigation (ZDCAN) module was developed to display a radiation free preview of the expected fluoroscopic image of the spine. Using an optical tracking system and a registered 3D-spine model, the expected x-ray image is displayed in real-time as a projection of the model. Additionally, selected anatomical structures including nerve roots, facet joints, vertebral discs and the epidural space, can be displayed. A seamless integration of the ZDCAN in a c-arm system already used in clinical practice for years could be achieved. For easy use, a tool was developed allowing the admission and use of regular single-use syringes and spinal needles. Accordingly, these can be used as pointers in the sterile area, a sterilization of the whole tool after every single injection is not required. We evaluated the efficiency and accuracy of this procedure compared to conventional fluoroscopically guided interventional procedures. In sawbones of the lumbar spine, facet joint injections (N = 50), perineural injections (N = 46) and epidural injections (N = 20) were performed.

Highlighting the target area in the radiation free preview model, an optimal positioning of the c-arm could be achieved even by unskilled medical staff. The desired anatomical structures could be identified easily in the x-rays taken, as they were displayed in the 3D model aside. As already seen evaluating a previous version of the ZDCAN module for the lower limb, the total number of x-ray images taken could be reduced significantly. Compared to the conventional group, the number of x-ray images required for facet joint injections could be reduced from 12.5 (±1.1) to 5.7 (±1.1), from 5.4 (±1.8) to 3.8 (±1.3) for perineural injections and from 4.1 (±0.9) to 2.1 (±0.3) for epidural injections. Total radiation time was reduced accordingly. Likewise, the mean time needed for the interventional procedure could be reduced from 168.3 s (±19.1) to 131.4 s (±16.8) for facet joint injections, was unchanged from 97.7 s (±26.0) to 104.7 s (±31.0) for perineural injections and from 60 s (±14.9) to 52 s (±7.1) for epidural injections.

The ZDCAN is a powerful tool advancing conventional fluoroscopy to another level. Using the radiation free preview model, the c-arm can easily be positioned to show the desired area. The accentuated display of the target structures in the preview model makes the introduction to fluoroscopy guided interventional procedures easier. This feature might reduce the learning curve to achieve better clinical results with lower radiation dose exposure. Thus, the ZDCAN can be a tool to improve education in university hospital settings for physicians as well as for medical staff while reducing radiation dose exposure in general use.

Background

Overlooked compartment syndrome represents a devastating complication for the patient. Invasive compartment pressure measurement continues to be the gold standard. However, repeated measurements in uncertain cases may be difficult to achieve. We developed a new, noninvasive method to assess tissue firmness by pressure related ultrasound.