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The Bone & Joint Journal
Vol. 103-B, Issue 9 | Pages 1472 - 1478
1 Sep 2021
Shoji T Saka H Inoue T Kato Y Fujiwara Y Yamasaki T Yasunaga Y Adachi N

Aims

Rotational acetabular osteotomy (RAO) has been reported to be effective in improving symptoms and preventing osteoarthritis (OA) progression in patients with mild to severe develomental dysplasia of the hip (DDH). However, some patients develop secondary OA even when the preoperative joint space is normal; determining who will progress to OA is difficult. We evaluated whether the preoperative cartilage condition may predict OA progression following surgery using T2 mapping MRI.

Methods

We reviewed 61 hips with early-stage OA in 61 patients who underwent RAO for DDH. They underwent preoperative and five-year postoperative radiological analysis of the hip. Those with a joint space narrowing of more than 1 mm were considered to have 'OA progression'. Preoperative assessment of articular cartilage was also performed using 3T MRI with the T2 mapping technique. The region of interest was defined as the weightbearing portion of the acetabulum and femoral head.


The Bone & Joint Journal
Vol. 101-B, Issue 4 | Pages 390 - 395
1 Apr 2019
Yasunaga Y Tanaka R Mifuji K Shoji T Yamasaki T Adachi N Ochi M

Aims

The aim of this study was to report the long-term results of rotational acetabular osteotomy (RAO) for symptomatic hip dysplasia in patients aged younger than 21 years at the time of surgery.

Patients and Methods

We evaluated 31 patients (37 hips) aged younger than 21 years at the time of surgery retrospectively. There were 29 female and two male patients. Their mean age at the time of surgery was 17.4 years (12 to 21). The mean follow-up was 17.9 years (7 to 30). The RAO was combined with a varus or valgus femoral osteotomy or a greater trochanteric displacement in eight hips, as instability or congruence of the hip could not be corrected adequately using RAO alone.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_11 | Pages 46 - 46
1 Aug 2018
Yasunaga Y Tanaka R Yamasaki T Syouji T Adachi N
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Adolescent and young adult patients with a history of DDH and residual hip dysplasia tend to have an early presentation of symptoms. In these patients, a severe acetabular dysplasia, aspheric femoral head and/or high greater trochanter are often observed. We evaluated the long-term results of rotational acetabular osteotomy (RAO) for symptomatic hip dysplasia in patients younger than 21 years.

We performed 492 RAOs for hip dysplasia from 1987 to 2017. In these cases, patients younger than 21 years at the time of surgery were 40 patients (46 hips). We evaluated 34 patients (40 hips, follow-up rate; 85%) retrospectively. There were 32 females and two males; their mean age at the time of surgery was 17.8 years (12–21). The mean follow-up period was 16.8 years (1–30). In eight hips, isolated RAO was not adequate to correct instability and/or congruency. For these hips, four varus femoral osteotomies, two valgus femoral osteotomies and two greater trochanter displacement were combined with RAO.

The mean clinical score (JOA) was improved from 80 to 90 significantly at the final follow-up. The mean CE angle was improved from −3.4 (−35–10) degrees to 27 (8–42) degrees, acetabular roof angle from 30 (15–60) degrees to 6.7 (−3–30) degrees, head lateralization index from 0.665 (0.5–1.0) to 0.614 (0.429–0.7) postoperatively. Radiographic OA progression was observed in four hips, but no hip was converted to THA.

The RAO is an effective technique for surgical correction of a relatively severe dysplastic hip in adolescent and young adults.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 85 - 85
1 Jan 2018
Yasunaga Y Fujii J Tanaka R Yamasaki T Shoji T Adachi N
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The transtrochanteric anterior rotational osteotomy (TRO) was developed by Sugioka as a joint-preserving procedure which prevents further deformity by transposing the necrotic area from a site of primary weight-bearing to a secondary area. We performed this procedure for children and young adults with various hip disorders.

Between 1994 and 2015 we performed TROs on 12 joints in 12 patients with SCFE (4), pigmented villonodular synovitis (2), septic arthritis (1), FAI (1), hip dysplasia (1), femoral neck fracture (2) and postoperative RAO (1). The mean age at the time of surgery was 21 years (10–43) and the mean follow-up period was 8 years (1–22). The rotational directions of the femoral head were anterior (5) and posterior (7). Clinical assessment was undertaken using the system of Merle d'Aubigné and Postel, grading pain, mobility and walking ability with scores from 0 to 6. Radiographically bone regeneration and OA progression were estimated.

The mean clinical score improved from 9.0 to 14.4 at final follow-up. Spur formation of femoral head was observed in 7 patients (58%). OA progression was in two patients (17%) and one patient was converted to THA 22 years after surgery. All cases with osteonecrosis in SCFE and femoral neck fracture showed remarkable bone regeneration.

The TRO is a reliable joint-preserving procedure for various hip disorders in children and young adults.


The Bone & Joint Journal
Vol. 99-B, Issue 9 | Pages 1140 - 1146
1 Sep 2017
Shoji T Yamasaki T Izumi S Murakami H Mifuji K Sawa M Yasunaga Y Adachi N Ochi M

Aims

Our aim was to evaluate the radiographic characteristics of patients undergoing total hip arthroplasty (THA) for the potential of posterior bony impingement using CT simulations.

Patients and Methods

Virtual CT data from 112 patients who underwent THA were analysed. There were 40 men and 72 women. Their mean age was 59.1 years (41 to 76). Associations between radiographic characteristics and posterior bony impingement and the range of external rotation of the hip were evaluated. In addition, we investigated the effects of pelvic tilt and the neck/shaft angle and femoral offset on posterior bony impingement.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_6 | Pages 107 - 107
1 Mar 2017
Yasunaga Y Yamasaki T Ochi M
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Background

The clinical results of total hip arthroplasty (THA) with a cementless prosthesis have been constantly improving due to progress in the area of stem design and surface finish. However, majority of stems are well-fixed with canal filling or diaphyseal fit, and cortical hypertrophy or metaphyseal bone atrophy has been often observed. Cementless Spotorno stem (CLS stem; Zimmer, Warsaw, USA) is a double-tapered rectangular straight stem. The purpose of this study is to investigate the mean 13 years' results of CLS stem and to evaluate the press-fit stability of CLS stem.

Methods

Between 1999 and 2004, we treated 134 patients (142 hips) with CLS stem. Of those patients, 86 females (92 hips) and 13 males (14 hips), in total 99 patients (106 hips) were available at minimum of 11 years after surgery. At the time of follow-up, six females and five males were dead. The follow-up rate was 82% and the mean follow-up period was 13 years (SD; 20, range; 11–16). The mean age at the time of surgery was 65 years (SD; 10, range; 38–86). The mean body mass index was 24 (SD; 1.8, range; 19 to 28). Preoperative diagnoses were osteoarthritis in 92 patients, osteonecrosis in five patients, and rheumatoid arthritis in two patients. Majority of the patients were female because 84 patients of osteoarthritis suffered from hip dysplasia. For cementless acetabular reconstruction, APR cups (Zimmer, Warsaw, USA) were implanted in 10 hips, IOP cups (Zimmer, Warsaw, USA) in 22 hips, and Converge cups (Zimmer, Warsaw, USA) in 74 hips. As the liner of acetabular component, conventional UHMWPE (Sulene: Zimmer, Warsaw, USA) was used in APR cup and highly crosslinked UHMWPE (Durasul: Zimmer, Warsaw, USA) in IOP and Converge cups. The lipped liner was chosen in all cases, and lipped lesion was placed posteriorly. The radiographic stability of the femoral stem was determined by Engh's criteria. The ascertained period of spot welds was noted by Gruen zones on the femoral side. The presence of stress shielding, and subsidence was also evaluated.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_4 | Pages 138 - 138
1 Jan 2016
Yamasaki T Yasunaga Y Ochi M
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Introduction

Clione Anchored Replacement Prosthesis (CARP-H system) is a novel femoral implant for cementless fixation at the metaphysis of the proximal femur and preservation of cancellous bone of the femoral diaphysis is expected (Fig.1). We developed CARP-H system and started to use the prosthesis after the approval by Pharmaceuticals and Medical Devices Agency in 2012. This study examines the efficacy and short-term outcome of CARP-H system in a series of patients undergoing total hip arthroplasty (THA) or bipolar hemi-arthroplasty (BHA).

Patients and Methods

Seventeen patients (17 hips) of osteonecrosis of the femoral head (ON) or osteoarthritis of the hip (OA) were included. The diagnoses were OA in 10 patients, and ON in 7 patients. The mean age at surgery was 55 years (35–62 years). The mean follow-up was 12 months (6–19 months). THA using CARP-H system was performed in 11 hips and BHA in 6 hips.


The Bone & Joint Journal
Vol. 96-B, Issue 2 | Pages 172 - 176
1 Feb 2014
Mori R Yasunaga Y Yamasaki T Nakashiro J Fujii J Terayama H Ohshima S Ochi M

In Japan, osteoarthritis (OA) of the hip secondary to acetabular dysplasia is very common, and there are few data concerning the pathogeneses and incidence of femoroacetabular impingement (FAI). We have attempted to clarify the radiological prevalence of painful FAI in a cohort of Japanese patients and to investigate the radiological findings. We identified 176 symptomatic patients (202 hips) with Tönnis grade 0 or 1 osteoarthritis, whom we prospectively studied between August 2011 and July 2012. There were 61 men (65 hips) and 115 women (137 hips) with a mean age of 51.8 years (11 to 83). Radiological analyses included the α-angle, centre–edge angle, cross-over sign, pistol grip deformity and femoral head neck ratio. Of the 202 hips, 79 (39.1%) had acetabular dysplasia, while 80 hips (39.6%) had no known aetiology. We found evidence of FAI in 60 hips (29.7%). Radiological FAI findings associated with cam deformity were the most common. There was a significant relationship between the pistol grip deformity and both the α-angle (p < 0.001) and femoral head–neck ratio (p = 0.024). Radiological evidence of symptomatic FAI was not uncommon in these Japanese patients.

Cite this article: Bone Joint J 2013;96-B:172–6.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_VIII | Pages 22 - 22
1 Mar 2012
Yamasaki T Yasunaga Y Hamaki T Yoshida T Oshima S Hori J Yamasaki K Ochi M
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Introduction

Since 2005, we have performed implantation of bone marrow-derived mononuclear cells for osteonecrosis of the femoral head in order to improve vascularization and bone repair. This study focused on early bone repair of osteonecrosis of the femoral head after transplantation of bone marrow-derived mononuclear cells (BMMNC).

Patients and Methods

Twenty-two patients (30 joints) who had bilateral osteonecrosis followed for more than 2 years after BMMNC implantation were evaluated. Eight women and 14 men were included. Their mean age at surgery was 41 years (range, 18 to 64 years) and the mean follow-up period was 31 months. Pre-operative stage according to the ARCO classification was Stage 2 in 25 joints and Stage 3 in 5 joints. The mean volume ratio of osteonecrosis was 21%. For preparing BMMNC, about 700ml of bone marrow was aspirated from the ilium and centrifuged using a Spectra cell separator (Gambro). The BMMNC were seeded to interconnected porous calcium hydroxyapatite (IP-CHA) and implanted to the osteonecrotic lesion. As a control, cell-free IP-CHA was implanted for 8 patients (9 joints). A woman and 7 men were included. The mean age at surgery was 49 years (range, 28 to 73 years) and the mean follow-up period was 37 months. Preoperative stage was stage 2 in all patients. The mean volume ratio of osteonecrosis was 22%. At post-operative evaluations; progression of collapse, consolidation at reactive zone, post-operative course of volume rate of osteonecrosis, and bone absorption at osteonecrosis was assessed.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 149 - 150
1 May 2011
Yasunaga Y Yamasaki T Hamaki T Yoshida T Oshima S Hori J Yamasaki K Ochi M
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Background: A retroverted acetabulum has been hypothesized as a cause of osteoarthritis. This study was performed to evaluate whether radiographical cross-over sign influence the painful femoro-acetabular impingement or the radiographical progression of osteoarhritis after rotational acetabular osteotomy (RAO) for dysplastic hip.

Methods: Between 1987 and 1999, 104 patients (115 hips) who had pre- or early stage osteoarthritis of the hip due to dysplasia underwent a RAO. There were 99 women and five men; their mean age at the time of surgery was 34.7 years. The mean follow-up period was 13 years. Clinical follow-up was performed with use of the system of Merle d’Aubigne and the impingement sign was evaluated. Radiographical analyses included measurements of the center-edge angle, acetabular roof angle, head lateralization index, joint congruency, cross-over sign, posterior wall sign, acetabular index of depth to width, pistol grip deformity and femoral head-femoral neck ratio.

Results: The mean clinical score improved significantly from 14.6 preoperatively to 17.0 at follow-up. The impingement sign at the follow-up was observed in 14 hips (12.2%). The center-edge angle improved significantly from mean −0.6 degrees to a postoperative mean of 34 degrees. The acetabular roof angle improved from 30 degrees to 2.2 degrees, and head lateralization index from 0.64 to 0.60. The cross-over sign was observed in 8 hips (7.0%) preoperatively and in 49 hips (42.6%) postoperatively. The posterior wall sign was observed in 70 hips (60.9%) preoperatively and observed in 73 hips (63.5%) postoperatively. The mean preoperative acetabular index of depth to width was 35.5% and the mean preoperative femoral head to femoral neck ratio was 1.49. The pistol grip deformity was observed in only 4 hips (3.5%) preoperatively. The impingement sign after the RAO was positive significantly in the postoperative cross-over sign positive hips (p=0.0074). Radiographical progression of osteoarthritis was observed in 11 hips (cross over sign positive; 7 hips, cross over sign negative; 4 hips). The Kaplan-Meier survivorship analysis predicted a survival rate of 84.6 % at 15 years. The only factors significantly associated with radiographic signs of progression of osteoarthritis after RAO were fair (rather than excellent and good) postoperative joint congruency (p< 0.0001) and age at surgery (p=0.0042). Presence of postoperative cross-over sign had no effect on the outcome (p=0.2073).

Conclusions: Although there was no significant radiographical progression of osteoarthritis despite a significant retroversion in most cases, the goal of RAO should be a correct alignment of the acetabulum including a correct version with a negative cross-over sign.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 3 | Pages 337 - 341
1 Mar 2010
Yamasaki T Yasunaga Y Ishikawa M Hamaki T Ochi M

We have investigated the effectiveness of the transplantation of bone-marrow-derived mononuclear cells (BMMNCs) with interconnected porous calcium hydroxyapatite (IP-CHA) on early bone repair for osteonecrosis of the femoral head. We studied 22 patients (30 hips) who had osteonecrosis with a minimum follow-up of one year after implantation of BMMNCs. The mean age at surgery was 41 years (18 to 64) and the mean period of follow-up was 29 months (19 to 48). In a control group, cell-free IP-CHA was implanted into a further eight patients (9 hips) with osteonecrosis of the femoral head and the outcomes were compared.

A reduction in the size of the osteonecrotic lesion was observed subsequent to hypertrophy of the bone in the transition zone in the BMMNC group. In three patients in the treatment group progression to extensive collapse was detected. In the control group subtle bone hypertrophy was observed, but severe collapse of the femoral head occurred in six of eight hips.

In this limited study the implantation of BMMNCs and IP-CHA appears to confer benefit in the repair of osteonecrosis and in the prevention of collapse.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 130 - 130
1 Mar 2006
Yasunaga Y Hisatome T Tanaka R Yamasaki T Ochi M
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Introduction. Dysplasia of the hip is the commonest cause of secondary osteoarthritis. One treatment is periacetabular osteotomy such as rotational acetabular osteotomy(RAO). These procedures have generally produced satisfactory mid- and long-term results, but unfavorable results have been reported in a few cases. We evaluated the 10-year results to determine the factors of prognostic importance.

Methods. We studied 91 patients (100 hips) at prearthritis or early stage. The mean age at surgery was 36 years (13 – 58) and mean follow-up period was 11 years (8–16). 81 were women (89 hips) and 10 were men (11 hips). Clinical follow-up was done using the system of Merle d’Aubigne. Radiologically, CE angle, AC angle and head lateralization index (HLI) were measured prior to surgery, 3 months postoperatively and at follow-up. Postoperative joint congruencies were classified into four grades.

Results. The mean clinical score significantly increased from 14 to 17 and only in 4 cases the mean score decreased. CE angle, AC angle, and HLI significantly improved after surgery. Progression of osteoarthritis was radiologically observed at follow-up in 7 hips. Kaplan-Meier survivorship analysis predicted the rate of prevention of osteoarthritic progression at 10 years as 93%. Parametric survivorship analysis using the Cox hazards model indicated that postoperative joint congruency is a risk factor for progression of osteoarthritis.

Discussion/Conclusion. Our findings have suggested that RAO is valuable in preventing osteoarthritic progression for at least 10 years. If risk factors can be reduced, a longer operative effect may be expected.