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Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_12 | Pages 22 - 22
1 Dec 2022
Werle J Kearns S Bourget-Murray J Johnston K
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A concern of metal on metal hip resurfacing arthroplasty is long term exposure to Cobalt (Co) and Chromium (CR) wear debris from the bearing. This study compares whole blood metal ion levels from patients drawn at one-year following Birmingham Hip Resurfacing (BHR) to levels taken at a minimum 10-year follow-up.

A retrospective chart review was conducted to identify all patients who underwent a BHR for osteoarthritis with a minimum 10-year follow-up. Whole blood metal ion levels were drawn at final follow-up in June 2019. These results were compared to values from patients with one-year metal ion levels.

Of the 211 patients who received a BHR, 71 patients (54 males and 17 females) had long term metal ion levels assessed (mean follow-up 12.7 +/− 1.4 years). The mean Co and Cr levels for patients with unilateral BHRs (43 males and 13 females) were 3.12 ± 6.31 ug/L and 2.62 ± 2.69 ug/L, respectively, and 2.78 ± 1.02 ug/L and 1.83 ± 0.65 ug/L for patients with bilateral BHRs (11 males and 4 females). Thirty-five patients (27 male and 8 female) had metal-ion levels tested at one-year postoperatively. The mean changes in Co and Cr levels were 2.29 ug/l (p = 0.0919) and 0.57 (p = 0.1612), respectively, at one year compared to long-term. These changes were not statistically significant.

This study reveals that whole blood metal ion levels do not change significantly when comparing one-year and ten-year Co and Cr levels. These ion levels appear to reach a steady state at one year.

Our results also suggest that regular metal-ion testing as per current Medicines and Healthcare products Regulatory Agency (MHRA) guidelines may be impractical for asymptomatic patients. Metal-ion levels, in and of themselves, may in fact possess little utility in determining the risk of failure and should be paired with radiographic and clinical findings to determine the need for revision.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_20 | Pages 94 - 94
1 Nov 2016
Werle J Khong H Smith C
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Many hospitals and orthopaedic surgery teams across Canada have instituted quality improvement (QI) programs for hip and knee arthroplasty. One of the common goals is to reduce hospital length of stay (LOS) in order to improve operational efficiency, patient flow and, by achieving this, provide improved access for patients to arthroplasty surgery. A common concern among surgeons and care providers is that hospital readmission rates will increase if LOS is significantly reduced. This study assesses the relationship between LOS and readmission rates in Alberta over a six year period during a focused QI initiative targeting LOS.

Data from all patients undergoing primary elective total hip or knee arthroplasty in Alberta between 2010 and 2015 was captured through a provincial QI program. Patient characteristics captured included age, gender, joint replaced, and pre-surgical co-morbidities. Patient LOS and all-cause hospital readmissions within thirty days from the initial discharge were captured through provincial data repositories, including the Discharge Abstract Database (DAD), operating room information systems, electronic medical records, and comorbidity risk grouper (CRG) data. Three longitudinal analyses were performed: 1) the crude and risk adjusted length of stay and 30-day readmission rates were calculated, 2) the population was grouped into two 3-year subsets and compared using t-test (acute LOS) and chi-square (30-day readmission), and 3) a multivariable regression analyses was performed to determine the rate of change and statistical significance in acute LOS and 30-day readmission between the two time periods.

The number of patients undergoing elective lower extremity arthroplasty in the province during the six-year study period (2010–2015) was 48,760 patients. Fifty-nine percent were female and forty-one percent were male. Mean age of the cohort was 66.9 years. Thirty-nine percent of patients had a total hip arthroplasty and 61% had a total knee arthroplasty. Forty-five percent of patients had no pre-surgical risk factors, 27% had one risk factor, and 28% of the patients had 2 or more risk factors. During the quality improvement program risk-adjusted length of stay improved from a mean of 4.82 days (in 2010–2012) to 3.90 days (in 2013–2015) (p<0.01). Controlling for differences in age, sex, joint replaced, and pre-surgery risk factors, the acute LOS declined by 0.32 days between the two time periods (p<0.001).

Quality improvement programs that target reduced LOS can avoid increasing 30-day hospital readmission rates. This has significant implications for inpatient resource utilisation for lower extremity arthroplasty surgery and for improving patient flow.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 165 - 165
1 Sep 2012
Powell JN Beaulé PE Antoniou J Bourne RB Schemitsch EH Vendittoli P Smith F Werle J Lavoie G Burnell C Belzile É Kim P Lavigne M Huk OL O'Connor G Smit A
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Purpose

The purpose of the study was to determine the rate of conversion from RSA to THR in a number of Canadian centers performing resurfacings

Method

Retrospective review was undertaken in 12 Canadian Centers to determine the rate of revision and reason for conversion from RSA to THR. Averages and cross-tabulation with Chi-Squared analysis was performed. kaplan Meier survivorship was calculated.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVIII | Pages 40 - 40
1 Sep 2012
Oliver MC Railton P Faris P Kinniburgh D Parker R MacKenzie J Werle J Powell J
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Purpose

Elevated blood metal ions are associated with the early failure of the Hip Resurfacing Arthroplasty. The aim of this study was to analyse our prospective database of Hip Resurfacing Arthroplasty patients, to independently review the outliers with elevated blood metal ions and to determine whether a screening program would be of value at our institution.

Method

In 2004 a ten year prospective longitudinal study was set up to evaluate the clinical effectiveness and safety of Metal on Metal Hip Resurfacings in young, active adults with degenerative hip disease.

Six hundred and four patients have enrolled in this multi-surgeon prospective study with strict inclusion criteria for Hip Resurfacing Arthroplasty. All have received the same implant design. All have completed validated functional outcome questionnaires at baseline, three and six months, then annually. A sub-cohort of 196 patients underwent whole blood chromium and cobalt analysis at the same time periods.

Metal on metal bearings have a running in period of a minimum of six months before a steady state wear pattern is attained. We chose five parts per billion for Cobalt or Chromium as our threshold value. This value corresponds to the workplace exposure limit in the United Kingdom to Cobalt in whole blood. Therefore patients with ion levels greater than five parts per billion after six months were recalled for independent review, including further metal ion analysis.