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The Bone & Joint Journal
Vol. 100-B, Issue 1 | Pages 66 - 72
1 Jan 2018
Suen K Keeka M Ailabouni R Tran P

Aims

α-defensin is a biomarker which has been described as having a high degree of accuracy in the diagnosis of periprosthetic joint infection (PJI). Current meta-analyses are based on the α-defensin laboratory-based immunoassay rather than the quick on-table lateral flow test kit. This study is the first meta-analysis to compare the accuracy of the α-defensin laboratory-based immunoassay and the lateral flow test kit for the diagnosis of PJI.

Materials and Methods

A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Inclusion criteria were all clinical studies where the diagnosis of PJI was uncertain. All studies selected used the Musculoskeletal Infection Society (MSIS) or modified MSIS criteria. Two independent reviewers reviewed the studies and extracted data. A meta-analysis of results was carried out: pooled sensitivity, specificity, positive and negative likelihood ratio, heterogeneity and areas under curves are reported.


The Bone & Joint Journal
Vol. 97-B, Issue 2 | Pages 208 - 214
1 Feb 2015
Chong A Nazarian N Chandrananth J Tacey M Shepherd D Tran P

This study sought to determine the medium-term patient-reported and radiographic outcomes in patients undergoing surgery for hallux valgus. A total of 118 patients (162 feet) underwent surgery for hallux valgus between January 2008 and June 2009. The Manchester-Oxford Foot Questionnaire (MOXFQ), a validated tool for the assessment of outcome after surgery for hallux valgus, was used and patient satisfaction was sought. The medical records and radiographs were reviewed retrospectively. At a mean of 5.2 years (4.7 to 6.0) post-operatively, the median combined MOXFQ score was 7.8 (IQR:0 to 32.8). The median domain scores for pain, walking/standing, and social interaction were 10 (IQR: 0 to 45), 0 (IQR: 0 to 32.1) and 6.3 (IQR: 0 to 25) respectively. A total of 119 procedures (73.9%, in 90 patients) were reported as satisfactory but only 53 feet (32.7%, in 43 patients) were completely asymptomatic. The mean (SD) correction of hallux valgus, intermetatarsal, and distal metatarsal articular angles was 18.5° (8.8°), 5.7° (3.3°), and 16.6° (8.8°), respectively. Multivariable regression analysis identified that an American Association of Anesthesiologists grade of > 1 (Incident Rate Ratio (IRR) = 1.67, p-value = 0.011) and recurrent deformity (IRR = 1.77, p-value = 0.003) were associated with significantly worse MOXFQ scores. No correlation was found between the severity of deformity, the type, or degree of surgical correction and the outcome. When using a validated outcome score for the assessment of outcome after surgery for hallux valgus, the long-term results are worse than expected when compared with the short- and mid-term outcomes, with 25.9% of patients dissatisfied at a mean follow-up of 5.2 years.

Cite this article: Bone Joint J 2015;97-B:208–14.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 84 - 84
1 Sep 2012
Halliday L Hannan D Tran P
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Total hip replacement can be performed successfully via a number of approaches. A patient's time to discharge following a THR is influenced by many factors. The anterior hip approach has recently been popularised as a true muscle sparing approach. This study looked at the association between operative approach (anterior, lateral or posterior), and length of hospital stay.

A retrospective review was conducted at Western Health, Victoria of 113 consecutive THRs performed at 3 hospitals (Footscray, Sunshine and Williamstown) by 16 surgeons over a 12 month period. The data was collected from the prospective information entered into the digital database ‘Sunray’ and a review of the postoperative notes in order to perform a retrospective audit. Statistical analysis included analysis of variance and pair-wise comparisons. Surgeons performed the surgery as clinically warranted, and no alteration was made of standard postoperative care or physiotherapy.

Of the 113 patients audited, the anterior approach for THR was found to be associated with a shorter length of stay in hospital when compared to both posterior approach (p=.0039) and lateral approach (p = .0512). The average length of stay after elective THR replacement was 6.9 days. The average length of stay for each approach was 4.3 days, 8.4 days and 6.4 days for anterior, posterior and lateral approach respectively. No significant difference was associated between operative approach and age.

Anterior approach to THR was associated with a shorter length of hospital stay.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 53 - 53
1 Sep 2012
Straub A Tran P
Full Access

The closed management of fractures and the application of plasters remains a core component of orthopaedic trauma management. A prospective audit was undertaken to analyse the quality of plasters presenting from various sources to the Fracture Clinic Plaster Technicians.

A prospective audit was conducted of 120 consecutive cases that presented to the Plaster Technicians at Western Health which had plasters applied by other institutions or other departments. The plasters were assessed on a number of criteria for adequacy and appropriateness using a standardised questionnaire and set guidelines.

63% of plasters applied were found to be deficient, inadequate or needed improvement. Of those applied by Theatre doctors, only 20% were appropriate. Of plasters applied by Emergency doctors only 10% were appropriate and those applied by General Practitioners were consistently deficient. Only trained plaster technicians had an acceptable rate of >90%. A large portion of the errors were due to incorrect moulding, joint position and fracture alignment.

Improperly applied plasters lead to increased morbidity, require reapplication or unnecessary operative procedures due to loss of position. Ongoing education and review is critical to address this situation, and a national online database is being designed and implemented to monitor this situation nationally.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 224 - 224
1 May 2006
Cohen D Tran P Duckett S Hall T Bruce C Dorgan JC
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Background: In times of blood shortage, the department of health plan to cancel elective surgery requiring more than 2 units of blood cross matching preoperatively. We assessed the use of blood products in scoliosis surgery and identified factors increasing the need for post operative blood transfusion.

Methods: Prospective data collection. Forty four patients underwent corrective spinal surgery between January 2003 and June 2004. Numbers of units of blood cross matched pre operatively and transfused post operatively were calculated. Subtype of scoliosis and surgical approach were also identified.

Results: All patients were cross matched 6 units of blood pre operatively, total of 264 units. Only 133 units were actually transfused, giving an overall 50.4 % product use rate. All syndromic patients were transfused blood irrespective of surgical approach. Idiopathic patients who had a one stage anterior approach did not require transfusion. Idiopathic patients were transfused a mean of 2.4 units and 2.9 units for one stage posterior and 2 stage approaches respectively. Syndromic patients were transfused a mean of 2.5 units, 5.8 units and 4.2 units for one stage anterior, one stage posterior and 2 stage procedures respectively.

Conclusion: The department of health published a paper on contingency planning for the shortage of blood products (1). In times of shortage, those surgeries requiring preoperative cross matching of more than 2 units will be cancelled first. Therefore, not only is it important to reduce the waste of blood products from a cost perspective, but also to cross match appropriately to avoid unnecessary cancellation if blood shortages occur. Surgical approach and underlying diagnosis need to be identified when cross matching patients for corrective scoliosis surgery. Idiopathic scoliosis patients only require 2 units of blood cross matching preoperatively. Patients with syndromes require 2–6 units depending on the surgical approach. A prospective validation trial has been implemented to validate our retrospective findings.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 255 - 255
1 Mar 2004
Tran P Bare J Hart J Forbes A Williamson O
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Aims: To compare digital imaging sent via email versus conventional radiographs in diagnosing and managing ankle fractures. Methods: Radiographs on a viewing box were photographed using a digital camera with a resolution of 1024 x 768 pixels at 24-bit colour depth. The resultant images were compressed using the JPEG (Joint Photographic Experts Group) format at a medium compression ratio and transmitted as email attachments. The mean size of the resultant files was 165 kByte (range146–209). The study radiographs, including 66 radiographs (33 A-P and 33 Lateral), were viewed by seven orthopaedic surgeons and assessed according to the classification of ankle fracture and the surgeons’ choice of management for that fracture. Over a four month interval, each surgeon was independently shown each set of patients’ radiographs 4 times: twice via JPEG format on a computer screen and twice via a conventional light box. Results: Results were analysed using weight kappa scores, interclass correlation and variance, for interobserver and intraobserver error for both diagnostic classification and for management decision. These results were then used to determine if there was a difference between interpretation of radiographs presented in the two different formats. There were no significant difference in diagnostic accuracy or management decisions between conventional radiographs and telemedicine reading. Conclusions: JPEG compression is suitable for transmission of X-ray