Aims

Cauda equina syndrome (CES) can be associated with chronic severe lower back pain and long-term autonomic dysfunction. This study assesses the recently defined core outcome set for CES in a cohort of patients using validated questionnaires.

Surgery for spinal deformity was previously carried out only in teaching hospitals in the United Kingdom. With increasing numbers of patients especially adults, seeking treatment for spinal deformity, the number of centres offering treatment for spinal deformity is going to have to increase.

The deformity part of the Spinal Surgical Service in the District General Hospital in Taunton started in 2005. This paper is an audit of this deformity service. It looks at two key areas – that of patient satisfaction and patient reported outcomes of surgery. Patient satisfaction was assessed by a validated questionnaire that evaluated a patient's perception of consultations, consent, preoperative assessment, operative and post operative experience and follows up visits. Patient reported outcomes were evaluated using the SRS 30 questionnaire. 104 patients were contacted and 95 patients (91%) responded. The overall patient satisfaction rate was 96%, with 87% very pleased with the result of surgery, 80% felt that their body shape had improved considerably, 62% had an increased ability to carry out day to day activities to a much higher level and 78% had significantly decreased pain after surgery. The results of the different domains of the SRS questionnaire also supported this.

The authors believe that this audit proves that it is possible to provide a spinal deformity service in a District General Hospital in the United Kingdom safely and effectively with a high degree of patient satisfaction. Audits of this kind are required to compare results of treatment between different centres and establish standards.

Study design

Economic evaluation alongside a prospective, randomised, controlled trial from a two-year National Health Service (NHS) perspective.

Introduction: A prospective randomised controlled trial of circumferantial spinal fusion has shown superior clinical outcome when a femoral ring allograft (FRA) is used compared to when a titanium cage (TC) is used. The implant cost of the TC is nearly ten fold that of the FRA. However the additional costs of surgery and related costs also need to be considered to determine if there is a real cost advantage of FRA over TC. We can find no previously reported studies which economically evaluate the TC and the FRA in circumferential lumbar spinal fusion. The aim of this study was to investigate cost-effectiveness of TCs in comparison to FRAs for circumferential lumbar spinal fusion over a two year National Health Service (NHS) perspective using a cost-utility evaluation

Methods: This randomised study had the approval of the local ethical committee and the institutional research and development board (Reference OR059844) prior to its commencement. Eighty-three patients were randomly allocated to receive either the TC or FRA as part of a circumferential lumbar fusion between 1998 and 2002. NHS costs related to the surgery and revision surgery needed during the trial period were monitored and adjusted to the base year (2005/6 pounds sterling). The Short Form-6D (SF-6D) was administered preoperatively and at 6, 12 and 24 months in order to elicit patient utility and subsequently Quality-Adjusted Life Years (QALYs) for the trial period. Return to paid employment was also monitored. Bootstrapped mean differences in discounted costs and benefits were generated in order to explore cost-effectiveness.

Results: Baseline demographic data including age, sex, smoking history, previous surgery history and number of operated levels did not differ between the two groups. A significant cost difference of £1,942 (AUD4,255), (95% CI £849 (AUD1,860) to £3,145 (AUD6,891)) in favour of FRA was found. Mean QALYs per patient over the 24 month trial period were 0.0522 (SD 0.0326) in the TC group and 0.1914 (SD 0.0398) in the FRA group, producing a significant difference of −0.1392 (95% CI 0.2349 to 0.0436). With regard to employment, incremental productivity costs were estimated at £185,171 (AUD 405,745) in favour of FRA.

Discussion: From an NHS perspective, the trial data show that TC is not cost-effective in circumferential lumbar fusion. The use of FRA was found to dominate (generating greater QALY gains and less cost). In addition FRA patients reported a greater return to work rate and hence, productivity costs were also in favour of FRA.

Introduction: etiology of late infection after arthroplasty can be difficult to establish. Histology is the gold standard for infection in patients without inflammatory arthritis but diagnosis in inflammatory arthritis depends on culture (Atkins et al). Real-time PCR offers a rapid and direct assessment for staphylococci and enterococci infection but has not been widely assessed.

The aims of this study were

to develop the Roche lightcycler Staphylococcal and Enterococcal PCR kits to facilitate diagnosis of hip and knee prosthetic infections

Methods: uplicate, multiple tissue samples were taken (with separate sterile instruments) at the 1^st stage of revision after informed consent. One set were cultured and results interpreted by the Oxford criteria. The second set were extracted using the Qiagen DNA kit, purified (in-house method) and tested using the Roche lightcycler kits.

Results:53 patients undergoing 2 stage revision for suspected infection were recruited.15 (28.3%) had negative histology and no inflammatory arthritis; 3 with single positive cultures and negative PCR – considered contaminants.

29 patients had non-inflammatory arthritis. 14/18 (77.8%) with positive cultures had staphylococci +/or enterococci isolated and 10 PCR results correlated. The other 11 patients had negative cultures.

9 patients had inflammatory arthritis. Six were culture negative and of the other three, 2 were positive for staphylococci on culture with 1 positive by PCR.

Discussion: Negative staphylococcal PCR correlates with the isolation of staphylococci from only one sample. This agrees with the Oxford criteria that such samples may be considered contaminants. Additional positives detected by staphylococcal PCR alone are rare.

Enterococcal PCR confirmed culture positivity in 2/3 patients. An additional 5 positive PCR’s were obtained from patients’ culture negative for enterococci. It is not clear if these are false positives or more sensitive detection of enterococcal isolation.

Study Design: Long-term retrospective case review of function in children with early onset scoliosis managed by selective anterior epiphysiodesis and posterior ‘Luque trolley’ growing instrumentation

Method: spinal and clinical function was assessed utilising SRS-22 and SF-36 outcome measures. The rates of secondary surgical procedures and further definitive fusion were recorded. Pulmonary function was assessed by standardised and averaged spirometric data at follow up.

Results: 25 patients have been clinically reviewed and functionally assessed (age range 6–35 years) mean age 17.7 years at follow up. 16 patients have reached skeletal maturity (8males, 8females) with mean follow up 11.8 years, to a mean age of 22.4 years. clinically 80% of cases were well balanced. At maturity the average loss of axial spinal growth measured 10.25cm (arm span- standing height) (range +4 cm to −21cm). In the immature cohort still growing, median shortening was 0.75%, with average height loss 1.63% of predicted. SRS- 22 and SF-36 questionnaires indicated moderate – good functional outcomes in 80% of patients. Spirometric data, with one case incapable of test compliance, demonstrates 24 % of patients had normal spirometric functional parameters, 32% had mild restrictive deficits, 12% had moderate and 28% had severe restrictive deficits. Poor spirometric function did not correlate with poor outcome measures. Over 50% had required further surgery.

Conclusions: Poor functional outcomes occurred in patients requiring early and multiple surgical revision procedures associated with loss of control or fixation of primary and secondary spinal deformities.

Study design: A retrospective review of patient records with recent clinical and radiographic assessment.

Objective: Long-term evaluation of the Luque trolley for posterior instrumentation in congenital scoliosis.

Summary of background data: From a group of 51 cases treated with the Luque trolley, we review 10 patients with progressive congenital scoliosis (5male, 5female) for a mean follow-up period of 14.8 years, to mean age of 19 years. The mean Cobb angle of the primary curve before surgery was 69.5 degrees. The mean Cobb angle of the secondary cervico-thoracic curve before surgery was 37.1 degrees and of the caudal secondary curve was 26.4 degrees. The mean age at surgery was 5.0 years. 8 patients had a selective epiphysiodesis procedure, 2 with hemi-vertebrectomy, and all underwent single- stage (7 patients) or dual-staged (3 patients) posterior instrumentation with a Luque trolley growing construct.

Method: Clinical evaluation and sequential measurements of Cobb angle were done, with recording of further surgical procedures, associated complications, and final coronal balance. The thoracolumbar longitudinal spinal growth (T1-S1) and growth in the instrumented segmented were also calculated.

Results: The mean preoperative primary curve Cobb angle of 69.5degrees, corrected to a mean postoperative angle of 30.6 degrees, with progression from here to curve magnitude of 38.8 degrees on latest follow up (approximate rate of progression of 0.55 degrees per year).

The mean pre-operative cephalic (cervico-thoracic) Cobb angle of 37.1degrees, corrected to 22 degrees, with progression to 26.6 degrees.

The mean pre-operative caudal (lumbar) Cobb angle of 26.4degrees, corrected to16.2 degrees, this later progressed to 20.6 degrees.

Coronal plane translation measured 1.68 cm at latest follow up [range 0.5–5.1cm].

The thoracolumbar longitudinal growth measured a mean of 8.81cm (approx0.8 cm/year) with a recorded lengthening of 2.54 cm (approx 0.23cm/year) in the instrumented segmented. Half the patients did not require further surgery.

Conclusion: Selective fusion does not always prevent further deformity in congenital scoliosis. The addition of posterior growing construct instrumentation did demonstrate capacity for good correction of primary and secondary curvatures and a limited capacity for further longitudinal growth.

We prospectively studied the outcome of a protocol of prophylaxis for deep vein thrombosis (DVT) in 103 consecutive patients undergoing surgical stabilisation of pelvic and acetabular fractures. Low-molecular-weight heparin (LMWH) was administered within 24 hours of injury or on achieving haemodynamic stability. Patients were screened for proximal DVT by duplex ultrasonography performed ten to 14 days after surgery.

The incidence of proximal DVT was 10% and of pulmonary embolus 5%. Proximal DVT developed in two of 64 patients (3%) who had received LMWH within 24 hours of injury, but in eight of 36 patients (22%) who received LMWH more than 24 hours after the injury (p < 0.01). We conclude that LMWH, when begun without delay, is a safe and effective method of thromboprophylaxis in high-risk patients with major pelvic or acetabular fractures.

Aim: The purpose of this study is to investigate the outcomes of bone conserving hip replacements: the Thrust Plate Prosthesis (TPP) and Buechel Pappas (BP) Resurfacing. Method:We have performed total hip replacements in 2 consecutive groups of young patients with osteoarthritis of the hips. In group 1 (TPP group) consists of 103 hips with the thrust plate prosthesis, HA coating and metal on metal bearings (1995~2000). The group 2 (BP group) consists of 25 hips with Buechel Pappas resurfacing with a thin polyethylene liner, ethylene oxide sterilized, and a nitrided titanium bearing surface (1989~1994). The outcomes were evaluated by complication rates, survival, standardized X-rays, a self-assessment satisfaction score, a Harris Hip Score and a Merle dñAubigne score. Results: In group 1, one hip had revision due to infection, and one following traumatic intertrochanteric fracture. No osteolysis and gross migration is seen In group 2, 17 of 25 hips had revision due to osteolysis or femoral neck fracture (mean 4y10m). Conclusion: The Thrust Plate Prosthesis has good outcome at 1 to 6 years follow-up. Buechel pappas resurfacing replacement had poor outcome and almost all cases had osteolysis, which are thought to be due to polyethylene particles.

Successful treatment of the infected arthroplasty remains a major concern to the revision surgeon. We aim to present our audit of the use of the Biomet Femoral Spacer in staged revision of the infected total hip arthroplasty.

Following removal and thorough debridement of the infected joint the spacer is created using the Biomet mould and the surgeon’s choice of cement with additional antibiotics.

Custom moulding allows for the incorporation of intramedullary devices to stabilize periprosthetic fractures.

The patient is then able to mobilize non weight bearing on the spacer until infectious parameters return to normal, before the second stage is attempted.

In our series fifty cases have been identified. Two dislocations, two prosthesis fractures and three repeat second stages are noted. Examples will be presented.

We believe the Biomet Femoral Spacer has a definite role in the management of this difficult problem.

We report the case of an 82-year-old man with a pathological fracture of the hip caused by infection with Histoplasma capsulatum var capsulatum. He was treated by a hemiarthroplasty and with oral itraconazole.