There is an increasing incidence of revision for periprosthetic joint infection. The addition of vancomycin to beta-lactam antimicrobial prophylaxis in joint arthroplasty may reduce surgical site infections, however, the efficacy and safety have not been established. This was a multicenter, double-blind, superiority, placebo-controlled trial. We randomized 4239 adult patients undergoing joint arthroplasty surgery to receive 1.5g vancomycin or normal saline placebo, in addition to standard cefazolin antimicrobial prophylaxis. The primary outcome was surgical site infection at 90-days from index surgery. Perioperative carriage of In the 4113 patients included in the modified intention-to-treat population, surgical site infections occurred in 72/2069 (3.5%) in the placebo group and 91/2044 (4. 5%) in the vancomycin group (risk ratio 1.28; 95% confidence interval 0.94 to 1.73; p value 0.11). No difference was observed between the two groups for primary hip arthroplasty procedures. A higher proportion of infections occurred in knee arthroplasty patients in the vancomycin group (63/1109 [4.7%]) compared with the placebo group (42/1124 [3.7%]; risk ratio 1.52; 95% confidence interval 1.04 to 2.23; p value 0.031). Hypersensitivity reactions occurred in 11 (0.5%) patients in the placebo group and 24 (1.2%) in the vancomycin group (risk ratio 2.20; 95% confidence interval 1.08, 4.49) and acute kidney injury in 74 (3.7%) patients in the placebo group and 42 (2.1%) in the vancomycin group (risk ratio 0.57; 95% confidence interval 0.39, 0.83). Perioperative This is the first randomized controlled trial examining the addition of a glycopeptide antimicrobial to standard beta-lactam surgical antimicrobial prophylaxis in joint arthroplasty. The addition of vancomycin to standard cefazolin prophylaxis
The direct anterior approach (DAA) for total hip arthroplasty continues to gain popularity. Consequently, more procedures are being performed with the patient supine. The approach often utilizes a special leg positioner to assist with femoral exposure. Although the supine position may seem to allow for a more reproducible pelvic position at the time of cup implantation, there is limited evidence as to the effects on pelvic tilt with such leg positioners. Furthermore, the DAA has led to increased popularity of specific softwares, ie. Radlink or JointPoint, that facilitate the intra-op analysis of component position from fluoroscopy images. The aim of this study was to assess the difference in cup orientation measurements between intra-op fluoroscopy and post-op CT. A consecutive series of 48 DAA THAs were performed by a single surgeon in June/July 2018. All patients received OPSTM pre-operative planning (Corin, UK), and the cases were performed with the patient supine on the operating table with the PURIST leg positioning system (IOT, Texas, USA). To account for variation in pelvic tilt on the table, a fluoroscopy image of the hemi-pelvis was taken prior to cup impaction, and the c-arm rotated to match the shape of the obturator foramen on the supine AP Xray. The final cup was then imaged using fluoroscopy, and the radiographic cup orientation measured manually using Radlink GPS software (Radlink, California, USA). Post-operatively, each patient received a low dose CT scan to measure the radiographic cup orientation in reference to the supine coronal plane.Introduction
Methods
Appropriate femoral stem anteversion is an important factor in maintaining stability and maximizing the performance of the bearing after total hip replacement (THR). The anteversion of the native femoral neck has been shown to have a significant effect on the final anteversion of the stem, particularly with a uncemented femoral component. The aim of this study was to quantify the variation in native femoral neck anteversion in a population of patients requiring total hip replacement. Pre-operatively, 1215 patients received CT scans as part of their routine planning for THR. Within the 3D planning, each patient's native femoral neck anteversion, measured in relation to the posterior condyles of the knee, was determined. Patients were separated into eight groups based upon gender and age. Males and females were divided by those under 55 years of age, those aged 55 to 64, 65 to 74 and those 75 or older.Introduction
Methods
Dissatisfaction rates after TKA are reported to be between 15 – 25%, with unmet outcome expectations being a key contributor. Shared decision making tools (SDMT) are designed to align a patient's and surgeon's expectations. This study demonstrates clinical validation of a patient specific shared decision making tool. Patient reported outcome measures (PROMs) were collected in 150 patients in a pre-consultation environment of one surgeon. The data was processed into a probabilistic predictive model utilising prior data to generate a preoperative baseline and an expected outcome after TKA. The surgeon was blinded to the prediction algorithm for the first 75 patients and exposed for the following 75 patients. PROMs collected were the knee injury and osteoarthritis outcome score (KOOS) and questions on lower back pain, hip pain and falls. The patients booked and not booked before and after exposure to the prediction were collected. The clinical validation involved 27 patients who had their outcome predicted and had their PROMs captured at 12 months after TKA. The predicted change in severity of pain and the patients actual change from pre-op to 12 month post operative KOOS pain was analysed using a Spearman's Rho correlation. Further analysis was performed by dividing the group into those predicted by the model to have improved by more than 10 percentile points and those who were predicted to improve by less than 10 percentile points.Introduction
Methods
The pelvis moves in the sagittal plane during functional activity. These movements can have a detrimental effect on functional cup orientation. The authors previously reported that 17% of total hip replacement (THR) patients have excessive pelvic rotation preoperatively. This increased pelvic rotation could be a risk factor for instability and edge-loading in both flexion and/or extension. The aim of this study was to investigate how gender, age and lumbar spine stiffness affects the number of patients at risk of excessive sagittal pelvic rotation. Pre-operatively, 3428 patients had their pelvic tilt (PT) and lumbar lordotic angle (LLA) measured in three positions; supine, standing and flexed-seated, as part of routine planning for THR. The pelvic rotation from supine-to-standing and from supine-to-seated was determined from the difference in pelvic tilt measurements between positions. Lumbar flexion was determined as the difference between LLA standing and LLA when flexed-seated. Patients were stratified into groups based upon age, gender and lumbar flexion. The percentage of patients in each group with excessive pelvic rotation, defined by rotation ≥13° in a detrimental direction, was determined.Introduction
Method
The pelvis moves in the sagittal plane during functional activity. This can be detrimental to functional cup orientation. Increased pelvic mobility could be a risk factor for instability and edge-loading, in both flexion and/or extension. The aim of this study was to investigate how gender, age and lumbar spine stiffness, affects the number of patients at risk of excessive sagittal pelvic mobility. Pre-operatively, 3428 patients had their pelvic tilt and lumbar lordotic angle (LLA) measured in three positions; supine, standing and flexed-seated. The pelvic rotation from supine-to-standing and from supine-to-seated was determined from the difference in pelvic tilt measurements between positions. Lumbar flexion was determined as the difference between LLA standing and LLA when flexed-seated. Patients were stratified into groups based upon age, gender, and lumbar flexion. The percentage of patients in each group with “at risk” pelvic rotation, defined by rotation ≥13° in a detrimental direction, was determined. There was an increased incidence of “at risk” pelvic mobility with increasing age, and decreasing lumbar flexion. This was more pronounced in females. Notably, 31% of elderly females had “at risk” pelvic mobility. Furthermore, 38% of patients with lumbar flexion <20° had “at risk” pelvic mobility. “At risk” pelvic mobility was more common in older patients and in patients with limited lumbar flexion. Additional stability, such as a dual mobility articulation, might be advisable in patient cohort. However, the majority of patients exhibiting “at risk” pelvic mobility were not older than 75, and did not have lumbar flexion <20°. This supports analysis of pelvic mobility on all patients undergoing THR.
Both navigation and instrumented bone referencing use unreliable intraoperative landmark identification or fixed referencing rules which don't reflect patient specific variability. PSI, however, lacks the flexibility to adapt to soft tissue factors not known during preoperative planning, in addition to suffering error from guide fit. A novel method of recreating surgical cut planes that combines preoperative image based identification of landmarks and planning with intraoperative adjustability is under development. This method uses an intraoperative 3D scan of the bone in conjunction with a preoperative CT scan to achieve the desired cuts and so avoids issues of intraoperative identification of landmarks. During TKA surgery, a reference device is placed on the exposed femur. The device is used to position a target block which is pinned to the bone (see Figure 1). The condyles and target block are then scanned, the process taking a second to complete. This 3D scan is filtered to remove extraneous bodies and noise leaving only the bony geometry and target block (see Figure 2). The scan is then reconciled to the known bone geometry taken from preoperative CT scans. A cutting block is then fixed to the target block with a reference array visible to the camera attached. Pre-planned cut planes on a computer model of the bone are compared to the position and configuration of the distal cutting guide. Software guides the surgeon in real-time on the necessary configuration changes required to align the cutting block. The cut is performed on the distal femur, the cutting guide removed from the target-block, and a second scan performed. The software repeats the filtering and alignment processes and provides the surgeon with data on how closely the performed cut matches the alignment planned.Introduction
Method
The pelvis rotates in the sagittal plane during daily activities.
These rotations have a direct effect on the functional orientation
of the acetabulum. The aim of this study was to quantify changes
in pelvic tilt between different functional positions. Pre-operatively, pelvic tilt was measured in 1517 patients undergoing
total hip arthroplasty (THA) in three functional positions – supine,
standing and flexed seated (the moment when patients initiate rising
from a seated position). Supine pelvic tilt was measured from CT
scans, standing and flexed seated pelvic tilts were measured from standardised
lateral radiographs. Anterior pelvic tilt was assigned a positive
value.Aims
Patients and Methods
The pelvis is not a static structure. It rotates in the sagittal plane depending upon the activity being performed. These dynamic changes in pelvic tilt have a substantial effect on the functional orientation of the acetabulum. The aim of this study was to quantify the changes in sagittal pelvic position between three functional postures. Pre-operatively, 90 total hip replacement patients had their pelvic tilt measured in 3 functional positions – standing, supine and flexed seated (posture at “seat-off” from a standard chair), Fig 1. Lateral radiographs were used to define the pelvic tilt in the standing and flexed seated positions. Pelvic tilt was defined as the angle between a vertical reference line and the anterior pelvic plane (defined by the line joining both anterior superior iliac spines and the pubic symphysis). In the supine position pelvic tilt was defined as the angle between a horizontal reference line and the anterior pelvic plane. Supine pelvic tilt was measured from computed tomography, Fig 2.Introduction
Methodology
Malorientation of the acetabular cup in Total Hip replacement (THR) may contribute to premature failure of the joint through instability (impingement, subluxation or dislocation), runaway wear in metal-metal bearings when the edge of the contact patch encroaches on the edge of the bearing surface, squeaking of ceramic-ceramic bearings and excess wear of polyethylene bearing surfaces leading to osteolysis. However as component malorientation often only occurs in functional positions it has been difficult to demonstrate and often is unremarkable on standard (usually supine) pelvic radiographs. The effects of spinal pathology as well as hip pathology can cause large rotations of the pelvis in the sagittal plane, again usually not recognized on standard pelvic views. While Posterior pelvic rotation with sitting increases the functional arc of the hip and is protective of a THR in regards to both edge loading and risk of dislocation, conversely Anterior rotation with sitting is potentially hazardous. We developed a protocol using three functional positions – standing, supine and flexed seated (posture at “seat-off” from a standard chair). Lateral radiographs were used to define the pelvic tilt in the standing and flexed seated positions. Pelvic tilt was defined as the angle between a vertical reference line and the anterior pelvic plane. Supine pelvic tilt was measured from computed tomography. Proprietary software (Optimized Ortho, Sydney) based on Rigid Body Dynamics then modelled the patients’ dynamics through their functional range producing a patient-specific simulation which also calculates the magnitude and direction of the dynamic force at the hip and traces the contact area between prosthetic head/liner onto a polar plot of the articulating surface. Given prosthesis specific information edge-loading can then be predicted based on the measured distance of the edge of the contact patch to the edge of the acetabular bearing. The position of the pelvis in the sagittal plane changes significantly between functional activities. The extent of change is specific to each patient. Spinal pathology can be an insidious “driver” of pelvic rotation, in some cases causing sagittal plane spinal imbalance or changes in orientation of previously well oriented acetabular components. Squeaking of ceramic on ceramic bearings appears to be multi factorial, usually involving some damage to the bearing but also usually occurring in the presence of anterior or posterior edge loading. Often these components will appear well oriented on standard views [Fig 1]. Runaway wear in hip resurfacing or large head metal-metal THR may be caused by poor component design or manufacture or component malorientation. Again we have seen multiple cases where no such malorientation can be seen on standard pelvic radiographs but functional studies demonstrate edge loading which is likely to be the cause of failure [Fig 2]. Clinical examples of all of these will be shown.Results and conclusions
A thorough understanding of wear patterns and failure mechanisms of TKA components in the context of pre-revision knee kinematics is advantageous for component designers, manufacturers and surgeons alike. Traditional gait analysis provides an experimental technique to determine in vivo kinematics but is often limited by its cumbersome nature, infrastructure intensiveness and time. The recent introduction of the KneeKG (Emovi Inc, Canada) as a stand-alone knee motion tracking system which uses infrared technology provides a great opportunity to quickly, easily and routinely monitor patients at the clinical level, especially those being revised for component failure. This pilot study was conducted to examine pre-revision knee kinematics and subsequent wear patterns and failure mechanisms observed on the UHMWPE inserts upon retrieval in a cohort of TKA revision patients. We hypothesize that motion patterns can provide surgeons a unique insight into the status of the UHMWPE insert and implant longevity. Patients requiring revision due to failure of the UHMWPE insert were recruited in this study after institutional ethical approval and written informed consent of the patients was obtained. Motion of the affected knee was quantified using a stand-alone infrared tracking system (KneeKG, Emovi Inc, Canada) whilst the patient was walking on a treadmill. All analyses were conducted within our institutional Physiotherapy Department. The KneeKG system is composed of passive motion sensors fixed on a validated knee harness, an infrared motion capture system (Polaris Spectra, Northern Digital Inc, USA) and a computer equipped with the Knee3D software suite (Emovi). Following application of the KneeKG trackers a calibration procedure was performed to identify joint centres and define a coordinate system on each body segment. After a treadmill habituation period of between 6 and 10 min, a trial was then conducted at the patient's comfortable treadmill gait speed over 45 sec. Averaged clinical rotations and translations of the tibia as a function of gait cycle were output by the system, and a report highlighting and detailing biomechanical deficiencies as compared to a database of normal controls automatically generated. Following the scheduled revision surgery the retrieved components were formalin-fixed and brought to our laboratory for a routine retrieval workup. All revisions were performed by a single surgeon. Components were analysed using optical and scanning electron microscopy techniques for regions of polishing, burnishing, pitting, delamination, deformation, scratching and embedded debris. Wear maps and scores were generated and correlated with pre-revision kinematics for each patient.Introduction
Methods
Achieving optimal acetabular cup orientation in Total Hip Replacement (THR) remains one of the most difficult challenges in THR surgery (AAOR 2013) but very little has been added to useful understanding since Lewinnek published recommendations in 1978. This is largely due to difficulties of analysis in functional positions. The pelvis is not a static reference but rotates especially in the sagittal plane depending upon the activity being performed. These dynamic changes in pelvic rotation have a substantial effect on the functional orientation of the acetabulum, not appreciated on standard radiographs [Fig1]. Studies of groups of individuals have found the mean pelvic rotation in the sagittal plane is small but large individual variations commonly occur. Posterior rotation, with sitting, increases the functional arc of the hip and is protective of a THR in regards to both edge loading and risk of dislocation. Conversely Anterior rotation, with sitting, is potentially hazardous. We developed a protocol using three functional positions – standing, supine and flexed seated (posture at “seat-off” from a standard chair). Lateral radiographs were used to define the pelvic tilt in the standing and flexed seated positions. Pelvic tilt was defined as the angle between a vertical reference line and the anterior pelvic plane (defined by the line joining both anterior superior iliac spines and the pubic symphysis). In the supine position pelvic tilt was defined as the angle between a horizontal reference line and the anterior pelvic plane. Supine pelvic tilt was measured from computed tomography. Proprietary software (Optimized Ortho, Sydney) based on Rigid Body Dynamics then modelled the patients’ dynamics through their functional range producing a patient-specific simulation which also calculates the magnitude and direction of the dynamic force at the hip and traces the contact area between prosthetic head/liner onto a polar plot of the articulating surface, Fig 2. Given prosthesis specific information edge-loading can then be predicted based on the measured distance of the contact patch to the edge of the acetabular liner. Delivery of desired orientation at surgery is facilitated by use of a solid 3D printed model of the acetabulum along with a patient specific guide which fits the model and the intra-operative acetabulum (with cartilage but not osteophytes removed) - an incorporated laser pointer then marks a reference point for the reamer and cup inserter to replicate the chosen orientation. The position of the pelvis in the sagittal plane changes significantly between functional activities. The extent of change is specific to each patient. Spinal pathology is a potent “driver” of pelvic sagittal rotation, usually unrecognised on standard radiographs. Pre-operative patient assessment can identify potential orientation problems and even suitability for hard on hard bearings. Optimal cup orientation is likely patient-specific and requires an evaluation of functional pelvic dynamics to pre-operatively determine the target angles. Post-operatively this technique can identify patient and implant factors likely to be causing edge loading leading to early failure in metal on metal bearings or squeaking in ceramic on ceramic bearings.Results and conclusions
Patient satisfaction has only recently gained attention as an outcome measure in orthopaedics, where it has been reported for joint replacement surgery. Little has been published regarding predictors of patient satisfaction in orthopaedic trauma. This study aims to explore the predictors of patient satisfaction, and of surgeon satisfaction, after orthopaedic trauma. Adult patients admitted to hospital with fractures after motor vehicle trauma were surveyed on admission, and at six months. Demographic, injury, socio-economic and compensation-related factors were measured. The two outcomes were satisfaction with progress of the injury, and satisfaction with recovery. The treating surgeons were also surveyed at six months to determine surgeon satisfaction with progress, and recovery (using the same questions), and the presence or absence of fracture union and any complications. Multivariate analysis was used to determine significant predictors of satisfaction for both groups, and satisfaction rates were compared between surgeons and patients using multivariable analysis. Of 306 patients recruited, 232 (75.8%) returned completed questionnaires, but only 141 (46.1%) surgeons responded. Patients rated their satisfaction with progress and recovery as 74.6% and 44.4%, respectively, whereas surgeon-rated satisfaction with progress and recovery was 88.0% and 66.7%, respectively (p<
0.0001). Significant predictors of patient dissatisfaction were: blaming others for the injury, being female, and using a lawyer. Patient-rated outcome was not significantly associated with objective injury or treatment factors. The only significant predictor of surgeon dissatisfaction was fracture non-union. Orthopaedic surgeons overestimated the progress of the injury and the level of recovery compared to patients’ own ratings. Surgeons’ ratings are influenced by objective, treatment-related factors, whereas patients’ ratings were not. Measures of outcome commonly used b y orthopaedic surgeons, such as fracture union, do not predict patient satisfaction.
We report the results of a 4- to 17-year clinical and radiological follow-up of 264 Charnley first-generation stems in comparison with those of 402 second- and subsequent-generation stems. The incidence of fracture was 4.1% in first-generation stems and 0.5% in second- and subsequent-generation stems. The incidence of stem loosening requiring or likely to require revision was 3.1% in first-generation and 11.4% in second-generation stems. We believe that the increased loosening rate in second- and subsequent-generation stems is due to their larger cross-sectional area, which produces an increase in flexural stiffness.
