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Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_15 | Pages 66 - 66
1 Nov 2018
Jethwa KR Abdelhaq A Sanghrajka AP
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Supracondylar fractures of the humerus (SCFH) are the most common type of paediatric elbow fractures. Due to beliefs that non-operatively managed SCFH may displace further from the original position, they are monitored with repeated radiographs and a large number are unnecessarily surgically pinned. Very limited evidence currently exists to support these beliefs. This study aimed to determine the incidence of late “significant” displacement (requiring surgical management) of non-operatively managed paediatric SCFH, and whether they necessitate close radiographic follow-up. Patients aged ≤16, with a SCFH, were included in this retrospective cohort study. All were initially managed non-operatively with at least one follow-up radiograph within six weeks of injury. Data from four consecutive years (2013–2016) was collected using the hospital's radiology database. Two observers independently analysed patient radiographs and classified fractures by the Gartland and AO systems. The incidence of late displacement was determined using follow-up radiographs and clinic notes. Of the 164 patients included in the study, one patient (Gartland Type II, AO Type III) suffered late displacement at two weeks, requiring surgical fixation. One further patient (AO Type II) had a persistent cubitus varus deformity (Baumann's angle 90°), with no long-term functional deficit. Incidence of late displacement was 0.6% (n=1). Our findings suggest that stable Gartland Type I/AO Type I and II fractures do not require repeated radiographic follow-up. However, some Gartland Type II/AO Type III fractures require monitoring. This could considerably reduce the financial costs for the healthcare system, and inconvenience to families, associated with repeated follow-ups.


The Bone & Joint Journal
Vol. 96-B, Issue 7 | Pages 984 - 988
1 Jul 2014
Pullinger M Southorn T Easton V Hutchinson R Smith RP Sanghrajka AP

Congenital Talipes Equinovarus (CTEV) is one of the most common congenital limb deformities. We reviewed the records of infants who had received treatment for structural CTEV between 1 January 2007 and 30 November 2012. This was cross-referenced with the prenatal scans of mothers over a corresponding period of time. We investigated the sensitivity, specificity, and positive and negative predictive values of the fetal anomaly scan for the detection of CTEV and explored whether the publication of Fetal Anomaly Screening Programme guidelines in 2010 affected the rate of detection.

During the study period there were 95 532 prenatal scans and 34 373 live births at our hospital. A total of 37 fetuses with findings suggestive of CTEV were included in the study, of whom 30 were found to have structural CTEV at birth. The sensitivity of screening for CTEV was 71.4% and the positive predictive value was 81.1%. The negative predictive value and specificity were more than 99.5%. There was no significant difference between the rates of detection before and after publication of the guidelines (p = 0.5).

We conclude that a prenatal fetal anomaly ultrasound screening diagnosis of CTEV has a good positive predictive value enabling prenatal counselling. The change in screening guidance has not affected the proportion of missed cases. This information will aid counselling parents about the effectiveness and accuracy of prenatal ultrasound in diagnosing CTEV.

Cite this article: Bone Joint J 2014;96-B:984–8.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 9 | Pages 1288 - 1291
1 Sep 2012
Sanghrajka AP Hill RA Murnaghan CF Simpson AHRW Bellemore MC

We describe three cases of infantile tibia vara resulting from an atraumatic slip of the proximal tibial epiphysis upon the metaphysis. There appears to be an association between this condition and severe obesity. Radiologically, the condition is characterised by a dome-shaped metaphysis, an open growth plate and disruption of the continuity between the lateral borders of the epiphysis and metaphysis, with inferomedial translation of the proximal tibial epiphysis. All patients were treated by realignment of the proximal tibia by distraction osteogenesis with an external circulator fixator, and it is suggested that this is the optimal method for correction of this complex deformity. There are differences in the radiological features and management between conventional infantile Blount’s disease and this ‘slipped upper tibial epiphysis’ variant.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 1 | Pages 12 - 18
1 Jan 2011
Eastwood DM Sanghrajka AP

Guiding growth by harnessing the ability of growing bone to undergo plastic deformation is one of the oldest orthopaedic principles. Correction of deformity remains a major part of the workload for paediatric orthopaedic surgeons and recently, along with developments in limb reconstruction and computer-directed frame correction, there has been renewed interest in surgical methods of physeal manipulation or ‘guided growth’. Manipulating natural bone growth to correct a deformity is appealing, as it allows gradual correction by non- or minimally invasive methods.

This paper reviews the techniques employed for guided growth in current orthopaedic practice, including the basic science and recent advances underlying mechanical physeal manipulation of both healthy and pathological physes.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 5 | Pages 628 - 631
1 May 2005
Dunstan E Sanghrajka AP Tilley S Unwin P Blunn G Cannon SR Briggs TWR

Metal-on-metal hip bearings are being implanted into younger patients. The consequence of elevated levels of potentially carcinogenic metal ions is therefore a cause for concern. We have determined the levels of cobalt (Co), chromium (Cr), titanium (Ti) and vanadium (Va) in the urine and whole blood of patients who had had metal-on-metal and metal-on-polyethylene articulations in situ for more than 30 years. We compared these with each other and with the levels for a control group of subjects.

We found significantly elevated levels of whole blood Ti, Va and urinary Cr in all arthroplasty groups. The whole blood and urine levels of Co were grossly elevated, by a factor of 50 and 300 times respectively in patients with loose metal-on-metal articulations when compared with the control group. Stable metal-on-metal articulations showed much lower levels. Elevated levels of whole blood or urinary Co may be useful in identifying metal-on-metal articulations which are loose.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 77 - 77
1 Mar 2005
Sanghrajka AP Dunstan ER Unwin P Briggs T Cannon SR
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Introduction: Deep infection following distal femoral endoprosthetic replacement remains an uncommon, (< 7%), but serious complication; we present the results all three-phase revisions performed at our unit.

Method: Using the endoprosthesis-survivorship database we identified and analysed 15 consecutive cases, (including MSTS functional assessment of all available patients), performed between 1993 and 2002. The primary replacement had been performed for trauma and fourteen for limb reconstruction following excision of tumour. All cases underwent a three-phase revision. The first stage involved debridement and exchange of prosthesis for a custom-made antibiotic-impregnated spacer. Following at least six weeks of intravenous antibiotics, a further endoprosthesis was inserted.

Results: Eight patients had complete clinical, radiological & biochemical resolution of infection, (mean follow-up 60 months). Mean MSTS score for this group was 83% (range 60–97%). The remaining seven had recurrence of infection, all within 18 months. Of this group, two underwent a successful second revision procedure with conversion to a total femoral replacement. Two cases are satisfactorily managed with antibiotic suppression therapy and three have required amputation. Two of these cases underwent above-knee amputation following a failed second revision, whilst the third was given a femoral stump endoprosthesis to avoid disarticulation. Revision was generally more successful in younger patients. Neither the original pathology nor the timing of revision surgery appeared to affect outcome. Negative tissue cultures from the first stage were associated with a successful result. Very high levels of inflammatory markers were associated with failure of revision

Conclusion: We recommend two-stage revision of distal femoral replacement as an effective treatment for infection, allowing limb salvage with excellent functional outcome in the majority of patients. The antibiotic phase may need to exceed six weeks in certain cases, and levels of inflammatory markers appear to be critical. If this revision fails, conversion to a total femoral replacement should be considered.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 76 - 76
1 Mar 2005
Sanghrajka AP Dunstan ER Unwin P Briggs T Cannon SR
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Introduction: We present a review of the long-term results of custom-made massive unicondylar femoral replacement for reconstruction following tumour excision, and compare the functional outcome of this procedure with prosthetic distal femoral replacement.

Method: Using our centre’s endoprosthetic database we identified and analysed all cases of massive unicondylar femoral replacement performed at our unit (group 1). Patients were evaluated for function, (Musculoskeletal Tumour Society System), and for stability (adapted from Oxford Knee Score). An age and sex-matched cohort of patients who had undergone distal femoral replacements for similar pathologies, and in who the follow-up was of a comparable time period (group 2) was evaluated in an identical manner. Statistical analysis was performed on the results.

Results: Twelve cases of massive unicondylar replacement have been performed between 1990 and 2001, for a variety of malignant and benign tumours. There have been no incidences of infection, aseptic loosening or tumour recurrence. One patient has died of metastatic disease and another has undergone revision to distal femoral replacement for osteoarthritis. Of the remaining ten patients, nine were available for assessment Each of the two groups consisted of 5 males and 4 females, with mean age 48 years in group 1 and 49 years in group 2. The average follow-up since surgery in both groups was 10 years. The mean MSTS and stability scores of group 1 were 83% and 3.9 respectively, and 71% and 3.2 for group 2; the difference in scores between groups was statistically significant, (p< 0.02).

Conclusion: With stringent case selection criteria, the custom-made massive unicondylar femoral replacement generally produces a good outcome, with functional results significantly better than distal femoral replacement. This may be because a substantial proportion of the knee joint with at least one cruciate and one collateral ligament are kept intact, thus facilitating enhanced proprioception.