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Bone & Joint Research
Vol. 11, Issue 3 | Pages 162 - 170
14 Mar 2022
The role of accelerated growth plate fusion in the absence of SOCS2 on osteoarthritis vulnerability
Samvelyan HJ Huesa C Cui L Farquharson C Staines KA
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Aims

Osteoarthritis (OA) is the most prevalent systemic musculoskeletal disorder, characterized by articular cartilage degeneration and subchondral bone (SCB) sclerosis. Here, we sought to examine the contribution of accelerated growth to OA development using a murine model of excessive longitudinal growth. Suppressor of cytokine signalling 2 (SOCS2) is a negative regulator of growth hormone (GH) signalling, thus mice deficient in SOCS2 (Socs2-/-) display accelerated bone growth.

Methods

We examined vulnerability of Socs2-/- mice to OA following surgical induction of disease (destabilization of the medial meniscus (DMM)), and with ageing, by histology and micro-CT.