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Bone & Joint Research
Vol. 1, Issue 11 | Pages 289 - 296
1 Nov 2012
The development of a novel model of direct fracture healing in the rat
Savaridas T Wallace RJ Muir AY Salter DM Simpson AHRW
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Objectives

Small animal models of fracture repair primarily investigate indirect fracture healing via external callus formation. We present the first described rat model of direct fracture healing.

Methods

A rat tibial osteotomy was created and fixed with compression plating similar to that used in patients. The procedure was evaluated in 15 cadaver rats and then in vivo in ten Sprague-Dawley rats. Controls had osteotomies stabilised with a uniaxial external fixator that used the same surgical approach and relied on the same number and diameter of screw holes in bone.