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Bone & Joint Research
Vol. 10, Issue 1 | Pages 77 - 84
1 Jan 2021
Antibiofilm efficacy of focused high-energy extracorporeal shockwaves and antibiotics in vitro
Milstrey A Rosslenbroich S Everding J Raschke MJ Richards RG Moriarty TF Puetzler J
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Aims

Biofilm formation is one of the primary reasons for the difficulty in treating implant-related infections (IRIs). Focused high-energy extracorporeal shockwave therapy (fhESWT), which is a treatment modality for fracture nonunions, has been shown to have a direct antibacterial effect on planktonic bacteria. The goal of the present study was to investigate the effect of fhESWT on Staphylococcus aureus biofilms in vitro in the presence and absence of antibiotic agents.

Methods

S. aureus biofilms were grown on titanium discs (13 mm × 4 mm) in a bioreactor for 48 hours. Shockwaves were applied with either 250, 500, or 1,000 impulses onto the discs surrounded by either phosphate-buffered saline or antibiotic (rifampin alone or in combination with nafcillin). The number of viable bacteria was determined by quantitative culture after sonication. Representative samples were taken for scanning electron microscopy.

Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 24 - 24
1 Dec 2018
CURRENT PRACTICES IN THE MANAGMENT OF OPEN FRACTURES: A WORLWIDE SURVEY AMONG ORTHOPAEDIC TRAUMA SURGEONS
Pützler J Zalavras C Moriarty F Verhofstad MHJ Stephen K Raschke M Rosslenbroich S Metsemakers W
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Aim

Infection rates after management of open fractures are still high. Existing guidelines regarding prevention of this complication are inhomogeneous. A survey directed to orthopaedic trauma surgeons worldwide aims to give an overview of current practices in the management of open fractures.

Method

An international group of trauma surgeons and infection specialists with experience in the field of musculoskeletal infections developed a questionnaire that was distributed via email to all AOTrauma members worldwide. Descriptive statistical analysis was performed.