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Bone & Joint Open
Vol. 2, Issue 8 | Pages 646 - 654
16 Aug 2021
Martin JR Saunders PE Phillips M Mitchell SM Mckee MD Schemitsch EH Dehghan N

Aims

The aims of this network meta-analysis (NMA) were to examine nonunion rates and functional outcomes following various operative and nonoperative treatments for displaced mid-shaft clavicle fractures.

Methods

Initial search strategy incorporated MEDLINE, PubMed, Embase, and the Cochrane Library for relevant randomized controlled trials (RCTs). Four treatment arms were created: nonoperative (NO); intramedullary nailing (IMN); reconstruction plating (RP); and compression/pre-contoured plating (CP). A Bayesian NMA was conducted to compare all treatment options for outcomes of nonunion, malunion, and function using the Disabilities of the Arm Shoulder and Hand (DASH) and Constant-Murley Shoulder Outcome scores.


The Bone & Joint Journal
Vol. 101-B, Issue 6_Supple_B | Pages 2 - 8
1 Jun 2019
Aggarwal VK Weintraub S Klock J Stachel A Phillips M Schwarzkopf R Iorio R Bosco J Zuckerman JD Vigdorchik JM Long WJ

Aims

We studied the impact of direct anterior (DA) versus non-anterior (NA) surgical approaches on prosthetic joint infection (PJI), and examined the impact of new perioperative protocols on PJI rates following all surgical approaches at a single institution.

Patients and Methods

A total of 6086 consecutive patients undergoing primary total hip arthroplasty (THA) at a single institution between 2013 and 2016 were retrospectively evaluated. Data obtained from electronic patient medical records included age, sex, body mass index (BMI), medical comorbidities, surgical approach, and presence of deep PJI. There were 3053 male patients (50.1%) and 3033 female patients (49.9%). The mean age and BMI of the entire cohort was 62.7 years (18 to 102, sd 12.3) and 28.8 kg/m2 (13.3 to 57.6, sd 6.1), respectively. Infection rates were calculated yearly for the DA and NA approach groups. Covariates were assessed and used in multivariate analysis to calculate adjusted odds ratios (ORs) for risk of development of PJI with DA compared with NA approaches. In order to determine the effect of adopting a set of infection prevention protocols on PJI, we calculated ORs for PJI comparing patients undergoing THA for two distinct time periods: 2013 to 2014 and 2015 to 2016. These periods corresponded to before and after we implemented a set of perioperative infection protocols.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 33 - 33
1 Oct 2018
Iorio R Aggarwal V Stachel A Phillips M Schwarzkopf R Vigdorchik JM Bosco JA Long WJ
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Introduction

There has been a renewed interest in the surgical approach used for total hip arthroplasty (THA). Risk factors for periprosthetic joint infection (PJI) have been well studied over the past decade, yet PJI remains one of the most devastating complications following THA. We studied the impact of direct anterior (DA) versus non-direct anterior (NA) surgical approaches on PJI, and examined the impact of new perioperative protocols on PJI rates following all surgical approaches at a single institution.

Methods

6086 continuous patients undergoing primary THA at a single institution from 2013–2016 were retrospectively evaluated. Data obtained from electronic patient medical records included age, sex, body mass index (BMI), medical comorbidities, surgical approach, and presence of deep PJI. Deep PJI was defined according to National Healthcare Safety Network's (NHSN) criteria for joint space infection following prosthetic hip replacement. Infection rates were calculated yearly for the DA and NA approach groups. Covariates were assessed and used in multivariate analysis to calculate adjusted odds ratios for risk of development of PJI with DA compared to NA approaches. In order to determine the effect of adopting a set of infection prevention protocols and patient optimization on PJI, we calculated odds ratios for PJI comparing patients undergoing THA for two distinct time periods: 2013–2014 and 2015–2016. These periods corresponded to before and after we implemented a set of perioperative infection protocols.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 36 - 36
1 Feb 2017
Bayers-Thering M Brown M Matthews J Phillips M Krackow K
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Abstract

A number of postoperative complications of navigated total knee arthroplasty have been discussed in the literature, including tracker pin site infection and fracture. In this paper we discuss the low postoperative complication rate in a series of 3100 navigated total knee arthroplasties and the overall complication rate in a systematic analysis of the literature.

Methods

3100 consecutive patients with navigated total knee arthroplasties from 2001 to 2016 were retrospectively evaluated for complications specific to navigation. We discuss the two cases of postoperative fracture through tracker pin sites that we experienced and compare this systematically to the literature.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XL | Pages 14 - 14
1 Sep 2012
Bayers-Thering M Krackow K McGrath B Phillips M
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Introduction

Genu recurvatum is a deformity rarely seen in patients receiving total knee arthroplasty. This deformity is defined as hyperextension of the knee greater than 5°. The incidence of recurvatum has been cited in the literature as less than 1%.

Purpose

The purpose of this study was to report data on 1510 consecutive total knee replacements (TKR) with navigation to demonstrate that the incidence of genu recurvatum is higher than what is cited in the literature.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 188 - 188
1 May 2012
Roger G Lane R Phillips M Huckson M Liang S
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Introduction

The concept and method of repeatedly connecting an extracorporeal blood pump to produce elevated pancycle inflow pressures to ischaemic limbs is presented. The aim of this study was to determine if intermittent increased perfusion would improve the clinical picture in peripheral arterial disease.

Methods

Animal studies—to determine the safety and efficacy of the pumping and the access device were performed on 12 sheep. Following successful completion of that study, pilot studies of 18 patients were treated using the Peripheral Access Device (PAD) and Hypertensive Extracorporeal Limb Hyperperfusion (HELP). Treatment was offered to patients who had no other alternative than major amputation. Patients were treated for less than 100 hours of total pumping, broken over three or less treatment periods over approximately one week. Improvement was measured by pain scores, clinical examination and digital thermography.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 426 - 426
1 Nov 2011
Antoci V Phillips M Antoci V K.A.
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Background: In the present study, the characteristics and mid-term to long-term outcomes of total knee arthroplasty (TKA) associated infections treated with different types of approaches were evaluated.

Methods: A retrospective study of the results of 71 infected TKA treated between August 1993 and August 2005. The data included medical records, gender, periprosthetic infection (PPI) classification, patients’ comorbidities, PPI diagnostic criteria, microbiology and histopathology results, surgical and antimicrobial therapy, treatment modality, complications, follow up, and treatment results.

Results: Median age was 70 years (range 43–88). Median follow-up 5.8 years (range 2–12). Thirty-three patients had multiple risk-factors for PPI. The main pathogens isolated were Coagulase-negative staphylococci 26 (37%), Staphylococcus aureus 16 (22.4%).

The treatment methods of TKA infection was two-stage exchange in 59 (83%), debridement and retention −5 (7.2%), arthrodesis −5 (7.2%), excision arthroplasty 2 (2.8%). At final followup, 17 knees (24%) had required reoperation: 10 knees (14%) -component removal for reinfection. Two knees were reinfected 3 times, three knees – two times. The median time to first reoperation for reinfection was 1.2 years (range, 0.04–2.5 years). By Kaplan-Meier survival analysis the estimated survivals free of reoperation for infection were 90.5% (confidence intervals, 85.3–96.1%) at 5 years and 82% (confidence intervals, 70.3–94.5%) at 10 years. The Knee Society scores: Pain scores, Functional scores, ROM improved.

Conclusions: TKA infections treatment is a difficult task leading to a high rate of unsatisfactory mid-term and long-term results. About one forth of patient require reoperation, 14% become reinfected in first 2.5 years. Half of reinfected patients get reinfected repeatedly. In most cases patients are reinfected with the same micro-organism but more virulent. TKA infection treatment option should be chosen according to the type of infection (acute or chronic), the duration of infection, the stability of the implant, the type of microorganism causing infection, bone quality and integrity, and the quality of the soft-tissue.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 303 - 303
1 May 2009
Antoci V Krackow K Phillips M Antoci V
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Infection is one of the most disturbing and frightening complications of total knee arthroplasty (TKA). The purpose of the present study was to review the management and outcomes of infected total knee arthroplasty.

The management and outcomes in 71 patients with 71 infected TKA was reviewed. Two-stage reimplantation with 8 weeks of intravenous therapy between the stages was used in 49 patients. Twenty-four patients ended with an arthrodesis using external fixation or intramedulary (IM) nailing. A two-stage technique was used with IM nail arthrodesis. Infections after TKA associated with bone destruction and loss were treated using an antibiotic-impregnated cement rod-spacer. Two patients required amputation: one because of soft tissue necrosis around the knee, another because of recalcitrant infection. In two patients the antibiotic-impregnated cement rod-spacer was chosen as a definitive treatment. The re-infection rate was about 25%. In most cases of reinfection the pathogens were the same, but of higher virulence and resistance. Infection was eradicated in 85% of patients. More than half of patients ended up with a functional TKA (average function score was 86.5 points, average range of motion from 2 to 109 degrees). One third of patients had a solid fusion. The infection could not be eradicated in 15% of patients.

The management and outcomes of infected total knee arthroplasty depend on a rapid and accurate diagnosis. A clear and effective management algorithm should yield favorable outcomes according to well-defined criteria. The two-stage reimplantation is the treatment of choice for chronic periprosthetic knee infection. Knee arthrodesis can be an effective treatment option after the failure of a TKA due to infection.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 56 - 56
1 Mar 2006
Street J Lenehan B Phillips M O’Byrne J McCormack D
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Management of symptomatic residual acetabular dysplasia in adolescence and early adulthood remains a major therapeutic challenge. At our unit the two senior authors review all patients preoperatively and simultaneously perform each procedure. In the four years from 1998 forty-three Bernese osteotomies were performed in 40 patients with residual acetabular dysplasia. The mean average age at surgery was 21 years (range 12 – 43 years) and there were 34 female patients. The indication for surgery was symptomatic hip dysplasia (all idiopathic but for one male with a history of slipped capital femoral epiphysis) presenting with pain and restricted ambulation. 4 patients had previous surgery on the affected hip (2 Salter’s osteotomy, one Shelf procedure and one proximal femoral osteotomy). 27.5% of patients had symptomatic bilateral disease. 42% of patients had Severin class IV or V dysplasia at presentation. 100% of patients had preservation of the hip joint at last follow-up evaluation (mean 2.4 years), with excellent results in 82%, an average post-operative Harris hip score of 96, and an average d’Aubigne hip score of 16.1. The mean post-operative improvements in radiographic measures were as follows: Anterior centre edge angle +19.4°, Lateral centre angle +25.8°, Acetabular Index – 10.7°. Head to Ischial distance – 7.3mm. Surgical operative time decreased from 128 minutes to 43 minutes from the first to the most recent case. Average blood loss has reduced from 1850mls to 420mls over the four years experience. Predonation of 2 units of blood requested from all patients with baseline hemoglobin of > 12g/dl. When combined with intraopera-tive cell salvage the need for transfusion of homologous blood has been eliminated. All complications occurred in the first 9 patients: (one major – iliac vein injury requiring no further treatment; four moderate – lateral cutaneous nerve injuries; four minor – asymptomatic heterotopic ossification). Our experience confirms that the Ganz periacetabular osteotomy is an efficacious procedure for the treatment of the residually dysplastic hip, providing excellent clinical results, where early intervention is the key to improved outcome. It is a technically demanding procedure with a significant early learning curve and we believe that a two


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 129 - 129
1 Feb 2004
Street J Phillips M O’Byrne J McCormack D
Full Access

Management of symptomatic residual acetabular dysplasia in adolescence and early adulthood remains a major therapeutic challenge. At our unit the two senior authors review all patients preoperatively and simultaneously perform each procedure. In the four years from 1998 forty-three Bernese osteotomies were performed in 40 patients with residual acetabular dysplasia. The mean average age at surgery was 21 years (range 12 – 43 years) and there were 34 female patients. The indication for surgery was symptomatic hip dysplasia (all idiopathic but for one male with a history of slipped capital femoral epiphysis) presenting with pain and restricted ambulation. 4 patients had previous surgery on the affected hip (2 Salter’s osteotomy, one Shelf procedure and one proximal femoral osteotomy). 27.5% of patients had symptomatic bilateral disease. 42% of patients had Severin class IV or V dysplasia at presentation. 100% of patients had preservation of the hip joint at last follow-up evaluation (mean 2.4 years), with excellent results in 82%, an average post-operative Harris hip score of 96, and an average d’Aubigne hip score of 16.1. The mean post-operative improvements in radiographic measures were as follows: Anterior centre edge angle +19.4°, Lateral centre angle +25.8°, Acetabular Index – 10.7°. Head to Ischial distance – 7.3mm. Surgical operative time decreased from 128 minutes to 43 minutes from the first to the most recent case. Average blood loss has reduced from 1850mls to 420mls over the four years experience. Predonation of 2 units of blood requested from all patients with baseline hemoglobin of > 12g/dl. When combined with intraoperative cell salvage the need for transfusion of homologous blood has been eliminated. All complications occurred in the first 9 patients: (one major – iliac vein injury requiring no further treatment; four moderate – lateral cutaneous nerve injuries; four minor – asymptomatic heterotopic ossification). Our experience confirms that the Ganz peri-acetabular osteotomy is an efficacious procedure for the treatment of the residually dysplastic hip, providing excellent clinical results, where early intervention is the key to improved outcome. It is a technically demanding procedure with a significant early learning curve and we believe that a two-surgeon approach is invaluable to the management of these difficult cases.