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Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 344 - 345
1 May 2010
Korovessis P Petsinis G Repantis T
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Objective. To evaluate the outcomes of the treatment of acute thoracolumbar burst fractures by transpedicular balloon kyphoplasty with Calcium phosphate cement and posterior instrumented fusion.

Methods: Twenty-three consecutive patients (average age 48 years) who sustained thoracolumbar A3-type burst fracture with or without neurologic deficit were included in this prospective study. Twenty-one out 23 patients had single fractures and the left 2 had each one additional A1 compression contiguous fracture. On admission 5(26%) out 23 patients had neurologic lesion (5 incomplete, one complete). Bilateral transpedicular balloon kyphoplasty was performed with quick hardening calcium phosphate cement to reduce segmental kyphosis and restore vertebral body height and supplementary pedicle screw instrumentation (long including 4 vertebrae for T9-L1 fractures and short (3 vertebrae) for L2 to L4 fractures. Gardner kyphosis angle, anterior and posterior vertebral body height ratio and spinal canal encroachment were calculated pre–to postoperatively.

Results: All 23 patients were operated within two days after admission and were followed for at least 24 months after index surgery. Operating time and blood loss averaged 70 minutes and 250 cc respectively. The 5 patients with incomplete neurologic lesions improved by at least one ASIA grade, while no neurological deterioration was observed in any case. Overall sagittal alignment was improved from an average preoperative 16o to one degree kyphosis at final follow up observation. The anterior vertebral body height ratio improved from 0.6 preoperatively to 0.9 (P< 0.001) postoperatively, while posterior vertebral body height was improved from 0.95 to 1 (P< 0.01). Spinal canal encroachment was reduced from an average 32% preoperatively to 20% postoperatively. No differences in preoperative values and postoperative changes in radiographic parameters between short and long group were shown. Cement leakage was observed in 4 cases: three anterior to vertebral body and one into the disc without sequalae. In the last CT evaluation, continuity was shown between calcium phosphate and cancellous vertebral body bone. Posterolateral radiological fusion was achieved within 6–8 months after index operation. There was no instrumentation failure or measurable loss of sagittal curve and vertebral height correction in any group of patients.

Conclusions: Balloon kyphoplasty with calcium phosphate cement secured with posterior long and short fixation in the thoracolumbar and lumbar spine respectively provided excellent immediate reduction of posttraumatic segmental kyphosis and significant spinal canal clearance and restored vertebral body height in the fracture level in an equal amount both in short and long instrumentation.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 299 - 299
1 May 2009
Korovessis P Repantis T Petsinis G
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Several methods of surgical treatment for pyogenic spondylitis have been reported including anterior approach, staged and simultaneous anterior decompression and posterior stabilisation. The use of anterior implants in the presence of infection presents still a challenge for spine surgeons.

Retrospective analysis of the clinical and radiological outcome of patients suffering from pyogenic spondylitis of the cervical and lumbar spine necessitating surgical treatment for intractable pain, instability and neurologic impairment.

Seventeen patients with spondylitis associated or not with paravertebral abscess were treated by one stage surgery (first: anterior decompression and placement of titanium mesh cage, filled with autologous iliac bone graft; second: posterior transpedicular instrumentation and fusion). The age of the patients was 54 ±15 years. Most of the patients had systematic problems such as lung tuberculosis, hepatic cirrhosis, diabetes mellitus or chronic renal failure. Patients were evaluated before and after surgery in terms of pain and neurological level, sagittal spinal balance and radiological fusion. All 17 patients were followed for 45 months.

Average duration of both surgeries was 4.5 hours. The VAS score improved from 7 (preoperatively) to 2 (postoperatively). The correction of the segmental kyphotic deformity was 6o, without loss of correction or cage migration or instrumentation failure. All patients with incomplete neurologic impairment improved postoperatively. There was neither migration of mesh cage nor posterior instrumentation failure at the follow up observation. There was an approach-related abdominal hernia.

This clinical study showed that patients with cervical and thoracolumbar osteomyelitis necessitating surgery for certain indications can successfully undergo instrumented combined, one-stage, same-day surgery. The presence of the mesh cage anteriorly at the site of infection had not negative but beneficial influence on the course of infection healing, and it additionally stabilised the affected segment, maintaining sufficient sagittal profile.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 132 - 132
1 Mar 2009
REPANTIS T KOROVESSIS P PETSINIS G REPANTI M
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Background: Recent studies have reported early periprosthetic osteolysis in patients who have been treated with a contemporary metal-on-metal total hip arthroplasty and suggested that metal hypersensitivity associated with an immunologic response to metal may be of etiologic importance. We evaluated the results and histologic findings in patients who underwent revision surgery for a failed contemporary metal-on-metal total hip arthroplasty.

Material and Methods: Two hundred and seventeen total hip arthroplasties (SL-Plus stem and Bicon-Plus cup) with a Sikomet metal-on-metal articulation were implanted in one hundred and ninety four consecutive patients and retrospectively reviewed at mean of 77 months postoperatively. Clinical follow up was performed with the Harris hip score and plain radiographic evaluation was performed. Histologic analysis was performed on the periprosthetic tissues of 14 hips that underwent revision arthroplasty.

Results: The mean Harris hip score improved from 45 preoperatively to 96 at final evaluation. Fourteen (6.4%) hips were revised: 9 for aseptic loosening, 2 for technical failure and three for septic failure. Histologic examination of the retrieved periprosthetic tissues from the eleven patients who underwent revision for aseptic loosening or technical failure showed microscopic metallosis and extensive lymphocytic and plasma cell infiltration around the metal debris. With an endpoint of removal of a component with aseptic loosening, endpoint survivorship was 93% for the stem and 98% for the cup respectively.

Conclusions: Our findings are in agreement with recent publications and support the possibility that periprosthetic osteolysis and aseptic loosening in hips with metal-on-metal articulation are possibly associated with hypersensitivity to metal debris. Prospective, comparative randomized long-term studies are necessary to determine the cause(s) of loosening of this particular articulation.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 40 - 41
1 Mar 2006
Petsinis G Repanti M Zacharatos S Korovessis P
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Introduction & Purpose of Study. The purpose of the present study was to evaluate the clinical, radiographic and histologic results with the Zweymueller total hip arthroplasty (THA) and metal-on-metal articulation. Material and Methods. Between 1994–2003, 380 patients received 415 third-generation Zweymueller-Plus THA with SL-stem and Bicon screw socket for hip osteoarthritis. Ten (5.15%) patients did not return for their last follow-up evaluation for reasons unrelated to their hip operation. This study reports on 217 THAs with follow up more than 60 months. The 217 THAs were implanted in 194 patients (143 women and 51 men), aged 55 ± 9 years, (25–70 years). The most common diagnosis for THA was primary osteoarthritis (48%) followed by secondary osteoarthritis due to developmental hip dysplasia (44%). Results. The follow-up was 77 ±17 months, (60 – 112 months). From the 217 THAs, 14 (6.4%) hips were revised for any reason; the socket in 5(2.3%) and the SL-stem in 9(4.1%) hips. The preoperative Harris hip score of 45±19 was improved to 96 ± 4 postoperatively. 95% of the patients were satisfied or very satisfied with the result of the operation. Revision was made in a total 14(4.6%) hips because of different reasons. The aseptic revision rate was 5%: 4(1.8%) Bicon cups and 7(3%) SL-stems were revised for aseptic loosening. The septic revision rate was 1.4% (3 THAs) and was due to Staph aureus. Periarticular ossification was observed in 32(17%) of the hips (5% Brooker grades III and IV), however without associated disability. The histological examination revealed mild metalosis (Mirra grades 1 and 2) in all revised hips. The cumulative survival for any reason (95% C.I.) was 90% (97% to 71%). The aseptic survival was 91% (97–72%) [95% CI); and specifically for the Bicon socket it was 98 % (100 to 92%); and for the SL-stem 93% (98% to 74%)[CI 95%]. The survival for the men and women was 78.9% and 94.4% respectively (log rank test: chi square P= 0.25). A significant, not statistically significant observation was that men showed lower survival for the stem than women (78.9 vs. 97.5%). Conclusion. This study showed that the medium-term results of Zweymueller total hip arthroplasty with metal-on-metal articulation were inferior particularly for the SL-stem to those obtained with the conventional Zweymueller total hip arthroplasty with polyethylene-ceramic articulation. This could be due either to allergic or mechanical (Sikomet Alloy) reasons.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 144 - 144
1 Mar 2006
Koureas G Zacharatos S Petsinis G Korovessis P
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Objectives: To investigate the influence of backpacks on the spine curves, shoulder level, trunk and back pain in schooladolescents.

Methods: 1263 students, aged 12 to 18 years, who carried backpacks over one or both shoulders to the school were asked for dorsal (DP) and/or low back pain (LBP). Kyphometer and Scoliometer were used to measure craniocervical angle (CCA), thoracic kyphosis, lumbar lordosis and shoulder level shift(BL) and biplane trunk deviations. Logistic and multinomial logistic analysis, t-test, Wilcoxon and chi-square tests were used for statistics.

Results: Backpacks decreased CCA (P< 0.001), and increased BL-shift(P< 0.001), and biplane trunk shift (P< 0.03). Girls suffer 6(P=0.001) times more from DP than boys. Students carrying backpacks asymmetrically suffer 3(P=0.035) and 5(P=0.014) more from DP and LBP respectively, than those symmetrically carrying. With increasing BMI decreases the possibility for DP at 10%(P=0.047) and increases at 10%(P=0.046) the possibility for LBP. With increase of BL-shift increases at 26%(P=0.024) DP. With increase of coronal trunk shift increases DP(P=0.011) and LBP(P=0.057). With increasing of sagittal loaded trunk shift increases LBP(P=0.065). In holidays: Girls suffer 3.2 times(P=0.050) more than boys in holidays; Asymmetrically carrying increases 8 times(P=0.006) back pain; Longer backpack carrying increases 2%(P=0.047) back pain; With shift of BL increases at 29.5%(P=0.042) back pain; With increase of coronal trunk shift increases 2.3 times(P=0.054) back pain. From high pain suffer: Girls suffer four times(P=0.015) more than boys; Asymmetrically backpack carrying increases four times(P=0.015) high pain; Increase of frontal trunk shift is associated by high pain three times (P=0.005) more.

Conclusion: Backpack carrying resulted in a forward lean of the upper trunk, and a decrease of cervical lordosis. Asymmetrically backpack carrying forced adolescents to rise the backpack bearing shoulder and simultaneously to shift the upper trunk contralaterally. These changes seem statistically to increase the incidence of back pain in the school period and during the holidays, particularly in girls. It is recommended that schoolchildren carry backpacks symmetrically with two straps.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 156 - 156
1 Mar 2006
Koureas G Petsinis G Zacharatos S Papazisis Z Korovessis P
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Purpose: Prospective randomized clinical and radiological study to compare the evolution of instrumented posterolateral lumbosacral fusion using either coralline hydroxyapatite(CHA), or iliac bone graft(IBG) in three comparable groups of patients.

Methods: 56 randomly selected adult patients with spinal stenosis were divided into three groups(A,B,C) included 17, 19 and 20 patients respectively and underwent decompression and fusion. The spines of Group A received IBG ; Group B IBG on the left side and CHA mixed with local bone and bone marrow on the right side; Group C CHA mixed with local bone and bone marrow bilaterally. The patients’s age was 61+11, 64+8 and 58+8 years for groups A, B and C respectively. SF-36, Oswestry Disability Index, and Roland-Morris surveys were used. Visual Analog pain Scale was used for pain. Roentgenograms (AP, lateral and oblique plus bending views) and CT-scans were used to evaluate the evolution of fusion. Two independent observers tested variability in evolution of the dorsolateral bony fusion 3 to 48 months postoperatively with the Christiansen’s and CHA resorption in Groups B and C.

Results: Intraobserver and interobserver agreement (r) for radiological fusion was 0.71 and 0.69 respectively, and 0.83 and 0.76 for evaluation of CHA resorption. There was no visible pseudarthrosis. Fusion was achieved one year postoperatively. CHA resorped 6 months postoperatively at the intertransverse spaces. Bone bridging started 3 months postoperatively in all levels posteriorly as well as between the transverse processes where IBG was applied. SF-36, Oswestry Disability Index, and Roland-Morris Score improved > 20 postoperatively in all groups. There was one pedicle screw breakage at the lowermost-instrumented level in group A and two in group C without pseudarthrosis. There was no deep infection. Operative time and blood loss were less in group C, while donor site complaints were observed in the patients of the groups A and B only.

Discussion & Conclusion: This study showed that autologous IBG remains the gold standard for posterior instrumented lumbar fusion to which each new graft should be compared. CHA was proven in this series not appropriate for intertransverse posterolateral fusion because the host bone in this area is little.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 358 - 358
1 Mar 2004
Korovessis P Deligianni D Petsinis G Baikousis A
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Aim: Periprosthetic fractures are usually difþcult to be stabilized using plates and screws because of the presence of the underlying intramedullary stem, PMMA cement and thin periprosthetic femoral cortex. Modern techniques using cerclages and bands may be useful. Material & Methods: This study compares Ç in vitro È the mechanical performance of þve different osteosynthesis techniques applied on a oak femoral model obliquely oscillated to mimic a short oblique fracture: (a) double stainless steel wiring, (b) two 4.5 mm lag screws, © combination of one 4.5 mm cortical screw and one stainless steel wire, (d) one titanium cerclage CCG (Compression Cerclage Gudolf) combined with one 4.5 mm screw, and (e) double CCG Cerclage. The þve þxation constructs were subjected to a non-cyclic destructive axial compression and torsional loading. Results: The highest torque stiffness showed the double CCG and the double screw constructs, followed by and combination of CCG-screw and double wire constructs. The mode of failure in torque was a longitudinal crack close to screw tip and loosening of CCG and wire. The double screw, double CCG and screw- CCG constructs provided the highest stiffness in axial compressive forces. The mode of failure under compression was either loosening of CCG and wire or bending of the screw. Conclusions: This comparative study showed that double CCG can used in the treatment of oblique periprosthetic femoral fractures with the advantages of the simple technique, biocompatibility of titanium, no interference in modern imaging techniques and avoidance of stripping of muscles and degloving of bone surfaces as in platting often happens.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 185 - 185
1 Feb 2004
Petsinis G Deligianni D Baikousis A Korovessis P
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Introduction-Aim: The fractures which occurred at the midshaft of the femur, in which there is a prosthesis, are difficult to stabilize using free screws or plates, because of the presence of the underlying intramedullary stem, PMMA cement and thin periprosthetic femoral cortex. Although the periprosthetic fractures are usually oblique with a big contact surface between the pieces of the fracture and with the datum of the intramedullary presence of the femoral stem of the prosthesis, which increases the stability, this study compares five different types of internal fixation a rather unstable «worst case scenario» oblique midshaft fracture of the femur.

Material & Methods: We compared «in vitro» the mechanical performance of five different ïsteosynthesis techniques applied on a oak femoral model obliquely oscillated to mimic a short oblique 60o fracture. We compared the following kind of osteosynthesis: (a) double stainless steel wiring, (b) two 4.5 mm lag screws, (c) combination of one 4,5 mm cortical screw and one stainless steel wire, (d) double CCG cerclage, and (e) one titanium cerclage CCG (Compression Cerclage Gudolf) combined with one 4.5 mm screw. The five fixation constructs were subjected to a noncyclic destructive axial compression and torsional loading.

Results: The highest torque stiffness showed the double CCG and the double screw constructs, followed by the combination of CCG-screw and double wire constructs. The mode of failure in torque was a longitudinal crack close to the screw tip and loosening of CCG and wire. The double screw, double CCG and screw-CCG constructs provided the highest stiffness in axial compressive forces. The mode of failure in compression was loosening of CCG and wire and bending of screw.

Conclusions: The advantages of using the CCG is the simple technique, biocomptability of titanium, no interference in modern imaging techniques and avoidance of stripping of muscles. The method with the CCG titanium band proved biomechanically so stable as the system with the double 4,5 mm screw and recommend an alternative solution for the osteosynthesis of the distal periprosthetic fractures of the femur, especially for the cases with periprosthetic osteoporosis.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_II | Pages 156 - 156
1 Feb 2004
Petsinis G Koureas G Repanti M Korovessis P
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Aim. The aim of this study is to estimate the medium-term results with the Zweymueller metal-on-metal THA in the osteoarthritis of the hip.

Material & Methods. A total of 266 consecutive patients, received 350 third-generation Zweymueller-SL total hip arthroplasties with metal-on-metal articulation for primary or secondary osteoarthritis. The age of the patients at the time of surgery was 55+9 years, (range 25–70 years). Seven (3%) patients did not return for their last follow-up evaluation and they excluded.

Results. The mean follow-up was 67 months (range 49–102 months). The preoperative Harris hip score was 45±19 and increased to 87±4 postoperatively. The invalidity of the patients was significantly improved postoperatively (p< 0.001). In all, 97% of the patients were satisfied or very satisfied with the result of the operation. There was no aseptic loosening noted in this series. Revision was done in 6 (1.8%) hips because of septic loosening (n=5, 1.5%) or technical error (n=1, 0.3%) during implantation. Dislocation of the prosthesis occurred in the early postoperative period in 2 (0.6%) hips because of technical errors during implantation. Periarticular ossification was observed in 30% of the hips (5% Brooker grades III and IV), but without associated disability. During revision surgery, no macroscopic metalosis could be identified in the newly formed hip joint membrane; how ever microscopic evidence for metalosis (Mirra grades 1 and 2) was seen in all revised hips. The survival for Zweymueller screw socket and stem 7.6 years after implantation was 99.4% and 96.8%, respectively.

Conclusion. The reasons of the loosening of Metal-on-Metal Zweymueller THA were the infection or the technical errors during implantation of the socket and nothing about the metal-on-metal articulation.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 352 - 352
1 Nov 2002
Friederich N König U Petsinis G
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Introduction

There are numerous arthroscopic techniques available for the treatment of femorotibial osteoarthritis. Advances in arthroscopic technology have made arthroscopic treatment a widespread accepted treatment. Short-term pain relief after arthroscopic treatment in degenerative conditions of the knee has been well established, however this this not the case for the long-term results.

One of the reasons why arthroscopic procedures are well accepted is the favorable risk–benefit ratio, when compared to more invasive procedures like realignment osteotomies, unicompartmental or even total knee arthroplasty (15,16,17,18,19,21,26) Very often the arthroscopic procedure is offered to the patient as a temporizing or “time gaining” measures (11,23,24). However their efficacy is often unequal. Almost no prospective controlled studies are yet available. Arthroscopic mosaicplasty techniques as well as arthroscopically assisted autologous chondrocyte transplantations are – in this context – not regarded upon as treatment options for the osteoarthritic knee and are therefore described elsewhere.

Arthroscopic techniques in knee osteoarthritis

- (Partial) Meniscectomy

- Chondral Shaving

- Removal of osteophytes

- Removal of loose bodies

- Synovectomy

- Subchondral drilling techniques (Pridie)

- Abrasive chondroplasty

- Microfracturing techniques

Results published in peer-reviewed journals

- (Partial) Meniscectomy: Results more dependent on the status of the knee joint, than on the age of the patient (15,17). For the treatment of chondrocalcinosis there are controversing results: Many authors found actually chondrocalcinosis to be an adverse prognostic factor (6,8,19). Meniscectomy is not always a benign procedure (5)

- Chondral Shaving: This technique of chondral debridement, removal of cartilaginous flaps etc. has become very accepted with the advent of motorized instruments. Positive short-term results have been published, on the long-term this treatment however still fails to have proven efficacy (1,2,3,9,10,11). In some studies simple needle lavage, as performed by many rheumatologists, proved as effective as the arthroscopic method (4,8,17).

- Removal of osteophytes: Several studies show a benefit, when mechanically disturbing osteophytes are removed (3,16)

- Removal of loose bodies: One of the most rewarding arthroscopic techniques. Only free bodies in the anterior compartment of the knee are responsible for blocking, catching and/or pain (6,9)

- Synovectomy: At the first moment making sense – removing inflamed synovia may be of benefit to the patient, we caution. Even when utilizing some of the newer radio-frequency ablation devices (Arthro-care® etc), important postoperative hemarthrosis may occur and may cause longstanding postoperative problems after knee arthroscopy (18,19)

- Subchondral drilling: Originally described by Pridie in 1959, this technique of “subchondral stimulation” creating and stimulating re-growth of type I collagen layers has been adapted to arthroscopic techniques (22)

- Abrasive chondroplasty: This rather aggressive technique, introduced by Lanny Johnson in 1986, has a decreased popularity, since almost nobody but the creator reported good mid- to long-.term results (7,12,13,25)

- Microfracturing: A similar technique to the Pridie drilling technique, however avoiding any heat damage due to the fact that the perforations of the subchondral plate are performed by “ice-picks”. Its advocates report good to excellent results on the short-term (20,27,28)