Introduction: The objective of the study was to test the hypothesis that revision total hip arthoplasty in cases with extensive acetabular bone defects performed with a newly developed, conical, titanium, ribbed shaft socket designed for cementless press-fit into the dorsocranial ilium would not demonstrate inferior outcomes using literature controls.

Methods: 38 consecutive hips had an acetabular revision with a pedestal cup. All of the patients had a type IIIa or IIIb defect according the Paprosky-classification. There was an average follow-up of 4.2 years, with a range of 3 to 6 years. Two patients died, one patient was lost to follow-up. All patients were evaluated radiographically, by CT-Scan and clinically.

Results: At the time of follow-up, 32 (91.4%) cups were stable. Aseptic loosenings occured in one case, septic loosenings occured in 2 cases. The average Harris Hip Score improved from 43 points (range: 16–78 points) preoperatively to 82 points (range 56–98 points) postoperatively. Complications included four dislocations without recurrency. The guide instrument facilitates correct anchorage in the dorsal ilium in all cases.

Conclusion: The presented findings show the short-term efficancy of the procedure with respect to implant fixation and clinical results in large acetabular defects, but longer follow-ups and a larger number of patients are needed before the durability of this reconstructive technique can be assessed. The implant allows restoration of the correct centre of rotation, equalization of leg length and optimization of the strength of the hip abductors. Our results should be considered encouraging.

Objectives: The replacement tissue used for anterior cruciate ligament reconstruction undergoes extensive biologic remodelling and incorporation after implantation. These changes, in which the tendon loses some of its characteristic features and adopts those typically associated with ligaments, has been referred to as ligamentization. The purpose of this study was to identify the proinflammatory response in the healing graft in the early phase.

Methodes: Twenty New Zealand White Rabbits underwent ACL reconstruction with a semitendinosus tendon. Animals were sacrificed at 3 and 6 weeks. The harvested tissue including parts of remaining grafted tendon and genuine anterior cruciate ligament at time of the surgery as well as the tendon graft withdrawn at sacrification were prepared for immunohistochemical, histomorphometry and electromicroscopical analysis; synovia samples were taken at the sacrification as well. The tissues were immunostained for IL-1beta, TGF-beta, TNF-alpha (induction of inflammatory cascade), COX-2 (mediator of inflammatory response), Matrix Metalloproteinases (MMP-1, MMP-3, MMP-13, matrix destructive enzymes), TIMP-2 (Tissue Inhibitor of MMPs); the PGE2 (mediator of inflammatory response) content in the synovia was quantified by ELISA.

Results: At 3 weeks after surgery the COX-2+ cells accounted for 70% of all cells present in the graft tissue, and decreased to 28% at 6 weeks. Similar, IL-1beta+ cells within the tendon decreased from week 3 to week 6. Controversly, there was an increase of COX-2, IL-1beta and MMP-1 in the intercellular tissue. The numbers of COX-2+ cells and IL-1beta+ cells at 3 weeks as well as the intercellular area stained positiv for COX-2, IL-1beta and MMP-1 at 6 weeks were significantly larger compared to the genuine ACL (p =< 0.05). At 3 weeks some cells stained positiv for MMP-3 and MMP-13, but not at 6 weeks. There was a slight pericellular staining for TIMP-2 at 3 weeks. TGF-beta+ cells and TNF-alpha+ cells were almost not detectable at every time point. Thus, proinflammatory cytokines and MMPs were synthesized in the early phase after ACL reconstruction by the tendon cells and accumulated at 6 weeks in the intercellular tissue.

Conclusions: In the early phase of the graft healing after ACL reconstruction, there was a signifikant increase in proinflammatory cytokines and matrix destructive enzymes in the tendon graft. With the capability of synthesizing cytokines, tendon cells may play a critical role in tendon healing at early time points. Facing the widespread use the bias of cox-2 inhibitors on these immunologic processes has to be checked. Activating matrix destructive enzymes, cytokines appear to be crucial for connective tissue remodelling and graft stability after ACL reconstruction.

The objective of this study was to evaluate the suitability of autologous periosteal cells for spinal fusion in humans. Lumbar spondylodesis has a slow consolidation rate with a consecutive lengthy period of inability to work and the risk of non-union. This study evaluates the applicability of a cell-matrix construct for spinal fusion using clinical and radiological parameters.

All experiments were approved by the university ethics committee. Lumbar spondylodesis of the segments L4/5 or L5/S1 was performed in 20 healthy patients (mean age 45 years). Indication for surgery was DDD resistant to conservative treatment. 10 weeks before fusion operation, a piece of periosteum was harvested from the proximal tibia of the patient. The material was chopped and digested. In the washed cell suspension cell number and viability were determined. The viability was greater 90% before seeding. After four passages, the cells were mixed with human fibrinogen, and soaked into polymer fleeces. Polymerization was achieved by adding thrombin. The 3D constructs were cultured for 3 weeks. The final application form were chips of 2mm thickness and 8mm diameter. Spondylodesis was performed using a ventral approach for implantation of 2 titanium cages and a dorsal approach for application of a transpedicular screw-rod system (Medtronic, Sofamor Danek). In 10 patients the chips were implanted ventrally within the cage. The other 10 patients obtained a dorsal intertransverse transplantation of the chips. Pre-operative, 3, 6, 9, and 12 months after surgery a clinical examination was performed, radiographs, and functional scores were obtained.

No implant associated side effects were noted. Especially, signs of infection or allergic reaction have not been observed. The harvest sites of all patients presented symptom-free after 3 months. The rate of consolidation was 60% after 6 months, 90% after 9 months, and 100% after 12 months. No clinical or radiological signs for implant failure or malpositioning were observed. 90% of the patients were satisfied with the outcome of the surgery.

Cultured autologous periosteal cells are a suitable material for anterior as well as posterior spinal fusion in humans. They may accelerate the rate of fusion and reduce the risk of non-union. Rate and velocity of osseous consolidation need to be compared to that of patients treated with iliac crest autograft. A major advantage might be the lower rate of graft site morbidity.

Despite all gain of knowledge, septic and aseptic loosening of endoprostheses still remain unsolved problems. In loosening of joint arthroplasty a periprosthetic membrane is found between the bone and the loosened implant. The characteristics of the membrane are influenced by the process that leads to the loosening of the endoprosthesis. The aim of the study was to introduce a classification system that enables a standardized diagnostic evaluation and helps to determine the aetiology of the loosening process.

Based on histomorphological criteria and polarized light microscopy, four types of periprosthetic membranes were defined: periprosthetic membranes of the wear particle type (type I), periprosthetic membranes of the infectious type (type II), periprosthetic membranes of the combined type (type III), and periprosthetic membranes of the indifferent type (type IV). Periprosthetic membranes of 268 patients were analyzed according to the defined criteria.

The interobserver reproducibility was sufficient (95%). The correlation between histopathological and microbiological diagnosis was high (89%, p< 0,001). The four types of periprosthetic membranes showed a significantly different time of revision.

This classification system enables a standardized diagnostic procedure. It therefore is a basis for further studies concerning the etiology and pathogenesis of prosthesis loosening. The reliability of this histomorphological examination in diagnosing infections is currently reviewed.

Bone-marrow oedema can occur both in isolation and in association with necrosis of bone, but it has not been shown whether each respond to the same methods of treatment.

We treated 16 patients with isolated oedema and 17, in which it was associated with necrosis of the proximal femur, with the prostacyclin derivative iloprost, which has been shown to be effective in the idiopathic form. The Harris hip score, the range of movement, the extent of the oedema as measured by MRI, pain on a visual analogue scale and patient satisfaction were recorded before and subsequent to treatment.

In both groups, we were able to show a significant improvement (p < 0.001) in these observations during the period of follow-up indicating that iloprost will produce clinical improvement in both circumstances.

Aims:We report our results with a Tantalum acetabular pressþt cup (Hedrocel), available since 1997. Although not coated its trabecular metal microstructure provides a good primary stability through a high friction against cancellous and cortical bone. An excellent bony ingrowth could be demonstrated in several animal experiments. Methods: 125 total hip arthroplasties were performed on 108 patients. All of them were followed up in a prospective manner 3, 6 and 12 months postoperatively. The outcome was quantiþed using the Harris hip and Merle dñAubigne scores and radiographic evaluation. Results: The Harris hip score raise from preoperative 44 to 87 after one year and the Merle dñAubigne score from 8 to 16. There were no signs of radiographic acetabular loosening. Sclerosis (Zone 1, 2 according to DeLee and Charnley) due to adaptation of the trabecular bone could be shown in most cases. The complication rate was on a low level (0.8% major, 3.2% minor complications) including 2 luxations, 2 relevant hematomas and 1 deep infection. Two cups had to be revised, one direct postoperatively for recurrent luxations due to an oversized inclination angle, the other for a deep infection. The infected cup was þrmly integrated, although it had to be explanted only a few weeks after implantation. Conclusions: Our results show, that the new Hedrocel acetabular cup has very good results with a good primary stability, a lack of radiographic loosening signs and an adaptation of the trabecular structures meaning a good osseous integration after one year. The long term results have to be obtained in the future.

Aim: The purpose of this study was to assess the results with use of a newly developed, conical, titanium, ribbed shaft socket designed for cementless pressþt into the dorsocranial ilium for revision total hip arthroplasty Methods: 25 hips had an acetabular revision with a pedestal cup (Centerpulse). All of the patients had a type III defect according the AAOS classiþcation. There was an average follow-up of 4.3 years, with a range of 3 to 5 years. One patient died during the study period. All patients were evaluated radiographically, by CT-Scan and clinically. Results: At the time of follow-up, 22 (91.7%) of 24cups were stable. Both loosenings affected patients with an low-grade infect. In this group none aseptical loosening occurred. The average Harris Hip Score improved from 41 points (range: 16–78 points) preoperatively to 84 points (range 56–98 points) postoperatively. Complications included four dislocations without recurrency. The radiological follow-up examinations revealed osteointegration of 21 implants. Conclusion: The presented þndings show the short-term efþcancy of the prcedure with respect to implant þxation and clinical results in large acetabular defects, but longer follow-ups and a larger number of patients are needed before the durability of this reconstructive technique can be assessed. Our results should be considered encouraging.

Aim: The purpose of study was to analyse osseous changes of tibial spine in radiographs of knees with aplasia of cruciate ligament. Methods: 13 patients with aplasia of cruciate ligament and respective x-rays were examined and analysed. Diagnosis were proofen by MRI or Arthroscopy. Moreover we checked patients with anterior and complete aplasia of cruciate ligament (s) separately. Results: We found typical signs of hypolasia and aplasia of intercondylar eminence in radiagraphs which correlate with anterior or complete aplasia of cruciate ligaments. These changes we classiþed in 3 types. Conclusion: Using this classiþcation it is possible to get a strong indication for aplasia of cruciate ligament only on the basis of x-rays.

Aim: The purpose of this study was to assess the results with use of an oval cementless acetabular component for revision total hip arthroplasty. Methods: 30 hips had an acetabular revision with an cementless oval acetabular component. No patient was lost to follow-up, but one died during the study period. All defects were classiþed during surgery according the AAOS classiþcation. All patients were evaluated radiographically and clinically and were followed for an average of thirty-six months (range, twenty four to fourty eight months). In 21 of the 30 hips no additional bone grafting was necessary. Results: There were 17 segmental defects (type 1), 12 combined defects (type III) and one case of pelvic discontinuity (type IV). At the time of follow-up, 27 (93.1%) of 29 cups were stable. One of the loosening affected the patient with pelvic discontinuity, the other a patient with a combined segmental defect including the medial wall. The average Harris Hip Score improved from 39 points (range: 15–73 points) preoperatively to 89 points (range 68–96 points) postoperatively. Complications included three dislocations without recurrency. The radiological follow-up examinations revealed good osteointegration of 27 implants. All postoperatively remaining defects were completly þlled in by bone at the follow up. Conclusion: The asymmetrical shape of the BOFOR enhanced the primary stabilty on the lateral columns with three point anchorage. We recommend this device when a patient has an oblong-shaped acetabular defect and the surgeon wants to correct an elevated hip center. However, the medial wall of the acetabulum (Kohlerñs line) should be intact.