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Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 29 - 29
1 Nov 2015
Pollalis A Grammatopoulos G Wainwright A Theologis T McLardy-Smith P Murray D
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Introduction

Joint preserving procedures have gained popularity in an attempt to delay arthroplasty in young, dysplastic hips. Excellent results can be achieved with peri-acetabular osteotomy (PAO) in congruent non-arthritic hips. The role of salvage procedures such as the Shelf acetabuloplasty remains undefined. This study aims to determine the long-term survival and functional outcome following Shelf acetabuloplasty and to identify factors that influence outcome.

Patients/Materials & Methods

This is a retrospective, consecutive, multi-surgeon, case series from a UK referral centre. 125 Shelf procedures were performed between 1987–2013 on 117 patients for symptomatic hip dysplasia. Mean age was 33 years (15–53). Mean follow-up was 10 years (1–27). Radiographic parameters measured included pre-operative arthritis, acetabular-index, centre-edge-angle, joint congruency, subluxation and femoral sphericity. Oxford Hip and UCLA scores were collected at follow-up. Failure was defined as conversion to arthroplasty or OHS<20.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 24 - 24
1 Nov 2015
Matharu G Mellon S Murray D Pandit H
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Introduction

This study aimed to: (1) compare published follow-up guidelines for metal-on-metal (MoM) hip patients and analyse protocols in relation to current evidence, and (2) assess the financial implications of these guidelines.

Methods

Follow-up guidance for MoM hips from five national authorities (MHRA in the UK; EFORT; United States FDA; Therapeutic Goods Administration of Australia; Health Canada) were contrasted and critically appraised. Using National Joint Registry (NJR) data (67,363 MoM hips implanted) the cost of annual surveillance for all MoM hips recorded in the NJR was calculated for each protocol.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_1 | Pages 92 - 92
1 Feb 2015
Murray D
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For medial compartment disease UKR has many advantages over TKR. They give better function, faster recovery, lower morbidity and mortality but have a higher revision rate. Matched studies from the England and Wales National Joint Registry showed they are 60% more likely to achieve excellent outcomes (OKS>41) and 30% more likely to have excellent satisfaction. UKR patients were discharged 1.4 days earlier, had 35% less readmissions and 50% less major complications such as DVT/PE, infection, CVA and MI. The death rate was significantly lower: The hazard ratios being 0.2x at 30 days, 0.5x at 90 days and 0.85x at 8 years. However at 8 years the revision rate was 2x higher and the reoperation rate was 1.4x. If 100 patients receiving TKR had UKR instead, the result would be around one fewer death and three more reoperations in the first 4 years. If patients were aware of this most would select a UKR.

The main reason why UKR have a high revision rate in registries is that most surgeons do small numbers and restrict their use to patients with very early disease, who often do badly. In the NJR 8% of knees are UKR and surgeons do on average 5 per year. Surgeons doing more than 20% of knees as UKR have a much lower re-operation rate which is similar to that of TKR. The Mobile bearing UKR can safely be used in up to 50% allowing many patients to have the advantages of UKR and a low re-operation rate.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 125 - 125
1 Jul 2014
Boissonneault A Lynch J Wise B Segal N Gross D Nevitt M Murray D Pandit H
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Summary

Anatomical variations in hip joint anatomy are associated with both the presence and location of tibiofemoral osteoarthritis (OA).

Introduction

Variations in hip joint anatomy can alter the moment-generating capacity of the hip abductor muscles, possibly leading to changes in the magnitude and direction of ground reaction force and altered loading at the knee. Through analysis of full-limb anteroposterior radiographs, this study explored the hypothesis that knees with lateral and medial knee OA demonstrate hip geometry that differs from that of control knees without OA.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 25 - 25
1 May 2014
Murray D
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Implant registries are set up to register implants. They therefore collect information about both primary and revision joint replacements. If a revision is linked to a primary it is then possible to determine the revision rate of the primary. This information is, however, of limited value as detailed information that affects the revision rate such as indications for the primary and the revision, and surgical technique used are not recorded. As a result comparisons of different implant designs and implant types are not reliable. For example implants that are commonly used in young or active patients are likely to have higher revision rates than those used in elderly sedate patients even though they may be better. Similarly, implants that are easy to revise will have higher revision rates than those more difficult to revise even if they provide better functional results. Finally, implants that are commonly used by more experienced surgeons will tend to have lower revision rates than those used by less experienced surgeons. Data from registries are therefore useful for identifying hypotheses that can formally be tested in other ways.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_8 | Pages 80 - 80
1 May 2014
Murray D
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Cemented unicompartmental knee replacement (UKR) has been used for many years and has excellent results in many follow-up studies. However, concerns about the quality of fixation, cementing errors, and radiolucent lines have encouraged the development of cementless prostheses. Mobile bearing UKR are probably the ideal implants for cementless fixation as the loads at the interface tend to be compressive. Prior to the widespread introduction of cementless mobile bearing UKR three studies have been performed to assess this device. In a randomised radiostereometric (RSA) study the migration of cementless and cemented devices were the same in the second year suggesting the quality of fixation achieved was similar. A clinical randomised study demonstrated a dramatic reduction in radiolucent lines with cementless components compared to cemented and no difference in clinical outcome. A prospective cohort study of 1000 patients demonstrated no overall difference in complications or revision rate and identified no contraindications for cementless fixation. There are however anecdotal reports of occasional tibial plateau fracture and early subsidence of cementless components. Data from the National Registers would suggest that the revision rate with cementless is about half that compared to cemented however this difference may be because only experienced surgeons are using the cementless device.

Cementless mobile bearing UKR does seem to be a good evolutionary step in the development of UKR. It is important however that surgeons are trained in the use of the device and are careful with the technique.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_30 | Pages 1 - 1
1 Aug 2013
Halai M Jayaram P Drury C Gregori A Murray D Oroko P Periasamy K
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Aluminia ceramic on ceramic (COC) bearing surfaces have been used for 35 years in total hip arthroplasty (THA). Studies report 85% survival at a minimum follow-up of 18.5 years. Nonetheless, an audible noise is a finding associated with COC bearings with incidence rates of 2–10%. This study aims to determine the prevalence of noise and evaluate its effect on patients.

All patients who had a COC THA from August 2003 to December 2010 were contacted and asked to complete a standardised questionnaire. This asked about the presence and characteristics of a noise and if associated with activities, pain and whether this phenomenon should be mentioned preoperatively.

Four consultant surgeons performed 282 consecutive primary COC THAs in 258 patients. (Male=122, Female=136 mean age 68.5; age range 28–88). In all cases, the same brand of ceramic acetabular component and stems were implanted. 11.0% had a noise, of which 5.5% had a squeak. Pain was experienced in 38.7% of patients in hips that made a noise. There was no trauma and one dislocation in this group. In this study, 85% of noises occur during weight-bearing although no patients have reduced daily activities as a result of the noises. Of all the patients, 55.0% stated they would have preferred to have known about a noisy hip possibility before consenting but none would have refused consent.

Squeaking has not been a problem here despite the prevalence being higher than most in the literature. The authors recommend that squeaking should be discussed preoperatively. A checklist for Orthopaedic Trainees is being drafted to enable trainees to counsel patients appropriately, allowing patients a better opportunity to give informed consent.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_26 | Pages 10 - 10
1 Jun 2013
Monk A Chen M Mellon S Gibbons M Beard D Murray D Gill H
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Previous attempts to measure coronal plane patellofemoral kinematics following knee replacement have suffered from methodological drawbacks; the patella being obscured by the components, metal artefact and technical inaccuracies. The aim of this study was to assess whether there was any significant difference in the patellofemoral kinematics between normal, TKR and PFJR patients using the validated MAUS™ technique (combining motion analysis with ultrasound).

60 patients were recruited into three groups; normal healthy volunteers (Normal), TKR, and PFJR patients. The MAUS technique incorporates a 12 camera analysis system (providing gross alignment data for tibial and femoral segments) and an ultrasound probe (providing coordinates of bony landmarks on patella femur and tibia) during a squat exercise. 6 DOF kinematics were described between 0 and 90° flexion. The validated accuracy of the MAUS technique registering the ultrasound images within the motion capture system is 1.84 mm (2 × SD).

Movements of the Normal group were significantly different from the TKR group (p=0.03) and the PFJR group (p<0.01), whilst there was no significant difference between the TKR and PFJR groups (p=0.27).

Our data suggest that many aspects of patellofemoral kinematics are absent following TKR and PFJR, which could be addressed in future designs of knee TKR and PFJR.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 113 - 113
1 May 2013
Murray D
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Unicompartmental Knee Replacement (UKR) is associated with fewer complications, faster recovery and better function than Total Knee Replacement (TKR). However, joint registers demonstrate a higher revision rate, which limit their use. Common reasons for revision include aseptic loosening and pain. Currently most UKRs are cemented; Cementless UKR was introduced to address these problems. In a randomised trial cementless fixation was found to have similar outcome scores but fewer radiolucencies than cemented fixation. It was also quicker and simpler. In a large multicentre cohort study in the hands of experienced surgeons it was found that following cementless UKR the incidence of complications was similar to cemented and there were no additional contra-indications. There were also no complete radiolucencies, which are common after cemented fixation. These studies demonstrate that cementless UKR are safe and effective and achieve better fixation with fewer radiolucencies than cemented UKR. They therefor suggest that cemented fixation should decrease the incidence of revision for aseptic loosening and for pain associated with radiolucency, and as a result the revision rate of UKR in the joint registers should decrease. Preliminary data from the registries demonstrates that this is happening.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 10 - 10
1 May 2013
Murray D
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Cement is the commonest method used to fix femoral components in the UK. This is not surprising as in the UK cemented fixation has provided better results than cementless fixation. The results of cemented fixation do however depend on the design of the stem. Polished collarless tapered stems are now the most widely used stems in the UK. These stems subside within the cement mantle thus compressing the cement and cement-bone interface and preventing these from failing. They are thus very tolerant of poor quality cementing. As a result aseptic loosening is extraordinarily rare even in young active patients. Compared with cementless fixation cement is very forgiving. It can be used with ease whatever the anatomy of the proximal femur and whatever the bone quality. Correct leg length can also easily be achieved. Thigh pain does not occur and intra-operative fractures are very rare. The antibiotics in the cement decrease the incidence of infection. In addition cement provides an effective barrier to particulate debris and joint fluid under pressure. The only real disadvantage of cemented fixation is that it may take longer than cementless fixation. However this extra time spent is compensated by the cheaper implant costs.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_22 | Pages 25 - 25
1 May 2013
Murray D
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It has been proposed that a major advantage of surface replacement is that it is easy to revise and that the outcome of such revisions is good. This seems logical as the femoral head can easily be removed, the acetabular component can be cut out and a primary hip replacement can be inserted. Indeed a number of studies have shown good outcome following revision, particularly for femoral neck fracture. When we initially reviewed the results of our revisions we found that the operations were straight forward and the results were good provided the reasons for revision were neck fractures, loosening, infection and causes other than soft tissue reactions. When the reason for revision was soft tissue reaction, otherwise known as pseudotumour, the outcome was unsatisfactory with poor hip scores, and high rates of complications, revisions and recurrences. These were generally a manifestation of the soft tissue damage caused by the pseudotumours. We therefor recommended that early revisions should be considered with soft tissue reaction. By undertaking revisions earlier we have found that the results have improved but there are still cases with poor outcomes.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 35 - 35
1 Jan 2013
Williams D Price A Beard D Hadfield S Arden N Murray D Field R
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Objectives

This study examines variations in knee arthroplasty patient reported outcome measures according to patient age.

Methods

We analysed prospectively collected outcome data (OKS, Eq5D, satisfaction, and revision) on 2456 primary knee arthroplasty patients. Patients were stratified into defined age groups (< 55, 55–64, 65–74, 75–84, and ≥85 years). Oxford Knee Score and Eq5D were analysed pre-operatively, and postoperatively at 6 months and 2 years. Absolute scores and post-operative change in scores were calculated and compared between age groups. Satisfaction scores (0–100) were analysed at 6 months post-operatively. Linear, logistic and ordinal regression modelling was used to describe the association between age and outcomes, for continuous, binary and ordinal outcomes, respectively. Kaplan-Meier analysis was performed to describe revision rates at 2 years.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 67 - 67
1 Jan 2013
Liddle A Pandit H Jenkins C Price A Gill H Dodd C Murray D
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Unicompartmental Knee Replacement (UKR) is associated with fewer complications, faster recovery and better function than Total Knee Replacement (TKR). However, joint registries demonstrate a higher revision rate in UKR, limiting its use. Currently most UKRs are cemented and performed using a minimally invasive technique. In joint registries, common reasons for revision include aseptic loosening and pain. These problems could potentially be addressed by using cementless implants, which may provide more reliable fixation.

The objectives of this study were to compare the quality of fixation (determined by the incidence and appearance of radiolucencies), and clinical outcomes of cemented and cementless UKR at five years.

A randomised controlled trial was established with 63 knees (62 patients) randomised to either cemented (32 patients) or cementless UKR (30 patients). Fixation was assessed with fluoroscopic radiographs aligned to the bone-implant interface at one and five years. Outcome scores were collected pre-operatively and at one, two and five years, including Oxford Knee Score (OKS), American Knee Society Score, objective and functional (AKSS-O/F) and Tegner Activity Scale (TAS), expressed as absolute scores and 0–5 year change (δ) scores.

Four patients died during the study period. There were no revisions. Mean operative time was 11 minutes shorter in the cementless group (p=0.029). At five years, there was no significant difference in any outcome measure except AKSS-F and δAKSS-F which were significantly better in the cementless group (both p=0.003). There were no femoral radiolucencies in either group. There were significantly more tibial radiolucencies in the cemented group (20/30 vs 2/27, p< 0.001). There were nine complete radiolucencies in the cemented group and none in the cementless group (p< 0.001).

Cementless fixation provides improved fixation at five years compared to cemented fixation in UKR, maintaining equivalent or superior clinical outcomes with a shorter operative time and no increase in complications.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 96 - 96
1 Jan 2013
Palmer A Thomas G Whitwell D Taylor A Murray D Price A Arden N Glyn-Jones S
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Introduction

Hip arthroscopy is a relatively new procedure and evidence to support its use remains limited. Well-designed prospective clinical trials with long-term outcomes are required, but study design requires an understanding of current practice. Our aim was to determine temporal trends in the uptake of non-arthroplasty hip surgery in England between 2001 and 2011.

Methods

Using procedure and diagnosis codes, we interrogated the Hospital Episode Statistics (HES) Database for all hip procedures performed between 2001 and 2011, excluding those relating to arthroplasty, tumour or infection. Osteotomy procedures were also excluded.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 217 - 217
1 Jan 2013
Jain N Kemp S Murray D
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Introduction

Patella tendonitis is common amongst sportsmen. No published evidence of this injury in elite professional footballers exists. The aim of this study was to determine the frequency of this injury in the elite professional footballer, along with the impact of such an injury on the amount of time missed and the outcomes of various treatment options.

Methods

Data was collected prospectively for injuries suffered by first team players, development squad players and academy squad players over the 2009–10 and 2010–11 English Premier League (EPL) season at one EPL club. Each player's demographics were recorded. The injury was recorded along with the time that the player was absent because of the injury, the treatment that the player received and whether they suffered any recurrence of the injury.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 66 - 66
1 Jan 2013
Liddle A Pandit H Jenkins C Price A Dodd C Gill H Murray D
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Indications for Unicompartmental Knee Arthroplasty (UKA) vary between units. Some authors have suggested, and many surgeons believe, that medial UKA should only be performed in patients who localise their pain to the medial joint line. This is despite research showing a poor correlation between patient-reported location of pain and radiological or operative findings in osteoarthritis. The aim of this study is to determine the effect of patient-reported pre-operative pain location and functional outcome of UKA at one and five years.

Pre-operative pain location data were collected for 406 knees (380 patients) undergoing Oxford medial UKA. Oxford Knee Score, American Knee Society Scores and Tegner activity scale were recorded preoperatively and at follow-up. 272/406 (67%) had pure medial pain, 25/406 (6%) had pure anterior knee pain and 109/406 (27%) had mixed or generalised pain. None had pure lateral pain. The primary outcome interval is one year; 132/406 patients had attained five years by the time of analysis and their five year data is presented.

At one and five years, each group had improved significantly by each measure (mean δOKS 15.6 (SD 8.9) at year one, 16.3 (9.3) at year five). There was no difference between the groups, nor between patients with and without anterior knee pain or isolated medial pain.

We have found no correlation between preoperative pain location and outcome. We conclude that localised medial pain should not be a prerequisite to UKA and that it may be performed in patients with generalised or anterior knee pain.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 22 - 22
1 Jan 2013
Mehmood S Pandit H Grammatopoulos G Athanasou N Ostlere S Gill H Murray D Glyn-Jones S
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Introduction

Solid or cystic pseudotumour is a potentially destructive complication of metal on metal (MoM) couples, usually needing revision surgery. However, complete clearance of the pseudotumour is unlikely at times. This prospective case-controlled study reports cases which had recurrence after revision surgery for pseudotumour related to metal on metal hip couples.

Methods

A total of 37 hips (33 MoM hip resurfacing and four big head MoM total hip arthroplasty (THA)) were revised for pseudotumour during the last 10 years. The patient demographics, time to revision, cup orientation, operative and histological findings were recorded for this cohort. Patients were divided into two groups - group R (needing re-revision for disease progression) and group C (control - no evidence of disease progression). Oxford hip scores (OHS, 0–48, 48 best outcome) were used to assess clinical outcome. The diagnosis of disease progression was based on recurrence of clinical symptoms, cross-sectional imaging, operative and histological findings.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 206 - 206
1 Jan 2013
Jain N Whitehouse S Foley G Yates E Murray D
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Introduction

Classification systems are used throughout Trauma and Orthopaedic (T&O) surgery, designed to be used for communication, planning treatment options, predicting outcomes and research purposes. As a result the majority of T&O knowledge is based upon such systems with most of the published literature using classifications. Therefore we wanted to investigate the basis for the classification culture in our specialty by reviewing Orthopaedic classifications and the literature to assess whether the classifications had been independently validated.

Methods

185 published classification systems within T&O were selected. The original publication for each classification system was reviewed to assess whether any validation process had been performed. Each paper was reviewed to see if any intra-observer or inter-observer error was reported. A PubMed search was then conducted for each classification system to assess whether any independent validation had been performed. Any measurement of validation and error was recorded.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 219 - 219
1 Jan 2013
Murray D Jain N Kemp S
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Introduction

Knee injuries are common amongst footballers. The aim of this study was to establish frequency and variation of knee injuries within one English Premier League (EPL) professional football club over two seasons, to assess number of days missed due to injury, and analyse current treatment regimen for each injury type.

Method

Data was collected prospectively for injuries suffered by players between 2009 and 2011, spanning two EPL seasons at one EPL club. Demographics were recorded along with various factors influencing injury, including playing surface, pitch condition, dominant side, type of injury, ability to continue playing, and mechanism of injury. Time taken for return to play, and treatment received was recorded.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 133 - 133
1 Sep 2012
Weston-Simons J Pandit H Haliker V Price A Dodd C Popat M Murray D
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Introduction

The peri-operative analgesic management of patients having either Total Knee Replacement (TKR) or Unicompartmental Knee Replacement (UKR) is an area that continues to have prominence, driven in part by the desire to reduce hospital stay, while maintaining high patient satisfaction. This is particularly relevant in the current climate of healthcare cost savings. We evaluated the role of “top up” intra-articular local anaesthetic injection after identifying that an appreciable number of patients in the unit suffered “breakthrough pain” on the first post-op day, when the effects of local analgesia are wearing off.

Method

43 patients, who were scheduled to have a cemented Oxford UKR, were prospectively recruited and randomised. All patients had the same initial anaesthetic regime of general anaesthesia, femoral nerve block and intra-operative intra-articular infiltration of the cocktail. All patients had a 16G multi-holed epidural catheter placed intra-articularly prior to wound closure. Patients had the same operative technique, post operative rehabilitation and rescue analgesia.

An independent observer recorded post-operative pain scores using a visual analogue score (1–10) every 6 hours and any rescue analgesia that was required. On the morning after surgery, 22 patients, (Group I), received 20 mls of 0.5% bupivicaine through the catheter whilst 21 patients, (Group II), had 20 mls of normal saline by the same observer, (who was blinded to the contents of the solution being injected), after which the catheter was removed.