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The Bone & Joint Journal
Vol. 96-B, Issue 12 | Pages 1681 - 1687
1 Dec 2014
Foruria AM Lawrence TM Augustin S Morrey BF Sanchez-Sotelo J

We retrospectively reviewed 89 consecutive patients (45 men and 44 women) with a mean age at the time of injury of 58 years (18 to 97) who had undergone external fixation after sustaining a unilateral fracture of the distal humerus. Our objectives were to determine the incidence of heterotopic ossification (HO); identify risk factors associated with the development of HO; and characterise the location, severity and resultant functional impairment attributable to the presence of HO.

HO was identified in 37 elbows (42%), mostly around the humerus and along the course of the medial collateral ligament. HO was hazy immature in five elbows (13.5%), mature discrete in 20 (54%), extensive mature in 10 (27%), and complete bone bridges were present in two elbows (5.5%). Mild functional impairment occurred in eight patients, moderate in 27 and severe in two. HO was associated with less extension (p = 0.032) and less overall flexion-to-extension movement (p = 0.022); the flexion-to-extension arc was < 100º in 21 elbows (57%) with HO compared with 18 elbows (35%) without HO (p = 0.03). HO was removed surgically in seven elbows.

The development of HO was significantly associated with sustaining a head injury (p = 0.015), delayed internal fixation (p = 0.027), the method of fracture fixation (p = 0.039) and the use of bone graft or substitute (p = 0.02).HO continues to be a substantial complication after internal fixation for distal humerus fractures.

Cite this article: Bone Joint J 2014;96-B:1681–7.


The Bone & Joint Journal
Vol. 95-B, Issue 12 | Pages 1595 - 1602
1 Dec 2013
Modi CS Beazley J Zywiel MG Lawrence TM Veillette CJH

The aim of this review is to address controversies in the management of dislocations of the acromioclavicular joint. Current evidence suggests that operative rather than non-operative treatment of Rockwood grade III dislocations results in better cosmetic and radiological results, similar functional outcomes and longer time off work. Early surgery results in better functional and radiological outcomes with a reduced risk of infection and loss of reduction compared with delayed surgery.

Surgical options include acromioclavicular fixation, coracoclavicular fixation and coracoclavicular ligament reconstruction. Although non-controlled studies report promising results for arthroscopic coracoclavicular fixation, there are no comparative studies with open techniques to draw conclusions about the best surgical approach. Non-rigid coracoclavicular fixation with tendon graft or synthetic materials, or rigid acromioclavicular fixation with a hook plate, is preferable to fixation with coracoclavicular screws owing to significant risks of loosening and breakage.

The evidence, although limited, also suggests that anatomical ligament reconstruction with autograft or certain synthetic grafts may have better outcomes than non-anatomical transfer of the coracoacromial ligament. It has been suggested that this is due to better restoration horizontal and vertical stability of the joint.

Despite the large number of recently published studies, there remains a lack of high-quality evidence, making it difficult to draw firm conclusions regarding these controversial issues.

Cite this article: Bone Joint J 2013;95-B:1595–1602.


The Bone & Joint Journal
Vol. 95-B, Issue 12 | Pages 1681 - 1686
1 Dec 2013
Peach CA Nicoletti S Lawrence TM Stanley D

We report our experience of staged revision surgery for the treatment of infected total elbow arthroplasty (TEA). Between 1998 and 2010 a consecutive series of 33 patients (34 TEAs) underwent a first-stage procedure with the intention to proceed to second-stage procedure when the infection had been controlled. A single first-stage procedure with removal of the components and cement was undertaken for 29 TEAs (85%), followed by the insertion of antibiotic-impregnated cement beads, and five (15%) required two or more first-stage procedures. The most common organism isolated was coagulase-negative Staphylococcus in 21 TEAs (62%).

A second-stage procedure was performed for 26 TEAs (76%); seven patients (seven TEAs, 21%) had a functional resection arthroplasty with antibiotic beads in situ and had no further surgery, one had a persistent discharge preventing further surgery.

There were three recurrent infections (11.5%) in those patients who underwent a second-stage procedure. The infection presented at a mean of eight months (5 to 10) post-operatively. The mean Mayo Elbow Performance Score (MEPS) in those who underwent a second stage revision without recurrent infection was 81.1 (65 to 95).

Staged revision surgery is successful in the treatment of patients with an infected TEA and is associated with a low rate of recurrent infection. However, when infection does occur, this study would suggest that it becomes apparent within ten months of the second stage procedure.

Cite this article: Bone Joint J 2013;95-B:1681–6.


The Journal of Bone & Joint Surgery British Volume
Vol. 92-B, Issue 2 | Pages 258 - 261
1 Feb 2010
Lawrence TM Wenn R Boulton CT Moran CG

We determined the age-specific incidence of a second fracture of the hip and compared it with that of a primary fracture in a study population drawn from 6331 patients admitted to Nottingham University Hospital with a primary fracture of the hip over a period of 8.5 years. The incidence of a second fracture was determined using survival analysis. The mean age-specific incidence rates of primary hip fracture were calculated using census data.

The overall incidence of a second fracture was 2.7% at one year and 7.8% at 8.5 years. That of a primary fracture was 50 per 100 000 in women aged 55 to 64 years rising to 3760 in those aged 84 years and over. The incidence of a second fracture in women aged 55 to 64 years was 2344 per 100 000. Patients of this age had a relative risk of 45 (95% confidence interval 13 to 155) for further fracture when compared with the population at risk of a first fracture. The incidence of a second fracture in women aged > 84 years was 2451 per 100 000 (relative risk 0.7, 95% confidence interval 0.5 to 0.9). A similar trend was seen in men.

Patients sustaining a primary fracture of the hip between the ages of 55 and 64 years have a much greater risk of further fracture than the normal population, whereas those over 84 years have a similar risk. These findings have important implications for the provision of fracture prevention services in primary and secondary care.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_I | Pages 17 - 17
1 Mar 2008
Lawrence TM Wenn R White C Moran CG
Full Access

The aim of this study was to determine the incidence of second hip fracture.

A prospective cohort study include 2682 patients aged 50 years or more admitted with a hip fracture over a 4 year period. Mortality data were available for all patients and survival analysis was performed to determine the incidence of second hip fracture. The mean age-specific incidence rates of primary hip fracture in the population were calculated to serve as a baseline.

95 patients (3.5%) sustained a sequential, contralateral hip fracture within the study period. The mean age at first hip fracture was 82 years and the mean interval between fractures was 316 days. Fracture morphology was similar on both sides in 69% of cases. Survival analysis demonstrated that the incidence of second hip fracture at 1 year was 2.8% (95% CI: 2.0–3.6), 2 years was 5.7% (95% CI: 4.3–7.1) and 3 years was 7.3% (95% CI: 5.4–9.2). The relative risk of hip fracture in patients who had already sustained one hip fracture was 2.4 times above that of matched controls. Assistance with activities of daily living was identified as a risk for second hip fracture (p=0.026, 95% CI: 1.058, 2.466). The odds ratio for sustaining a second hip fracture compared with the incidence of primary hip fracture in the normal population aged 55–64 years was 47.5 xs; 65–74 years was 15 xs; 75–84 years was 3.7x and 85+ years was 1x.

The risk of sustaining a second contralateral hip fracture is substantial. In younger patients preventative measures can be targeted at the individual who has sustained a fracture whereas in more elderly patients, preventative measures need to address the population as a whole.