We questioned about bearing surface and infection in two populations of patients who had bilateral THA with different bearings performed in the same hospital by the same surgical team from the year 1981 to the year 2010 (mean followup 15 years; 7 to 35).

1) first population (mean age 32 years): 325 patients (650 hips) with sickle cell disease (SCD) with two different bearing on each side. 116 patients had Metal on PE (MoP) on one side and Ceramic on PE (CoP) on the contralateral; 106 patients had (CoP) and Ceramic on Ceramic (CoC); 103 patients had MoP and CoC. 2) matched control population (same age, same period) of 820 patients without co-morbidities: 354 patients had MoP and CoP; 237 had CoP and CoC; 229 had MoP and CoC.

Among the 2290 hips, 3 early (less than 12 months) unilateral infections (2 in the controls, 1 in the SCD), and 59 late unilateral infections: 23 (1.4%) in 1640 THAs control, versus 36 (5.5%) in the SCD 650 THAs (P < 0.0001) during the observation period of 35 years.

In control group with the Kaplan-Meier analysis, increase infections over time but different (p=0.02) for each bearing surfaces, respectively from 0% at one year to 0.4% revision (2 cases) at most recent follow-up for 466 CoC hips, from 0% to 1.1% (7 cases) for 591 CoP hips, and from 0.3% to 2.4% (14 cases) for 583 MoP hips.

In sickle cell disease group MoP hips had higher risk of infection (26 among 219) when compared with CoP (9 among 222; p=0.002), and CoC (1 among 209 hips; p=0.0004); with increase over time from 1% at one year to 4% with CoP, and from 1% to 11.8% with MoP.

When contralateral hip of same patient is control, PE components are more prone to infection than those involving ceramic-on-ceramic.

It is unknown whether the risk of periprosthetic femoral fracture is the same in patients with two different bearing surfaces, ceramic on ceramic (CoC) and ceramic on polyethylene (CoP).

We retrospectively reviewed selected 126 patients (252 hips) with bilateral THA (one ceramic-ceramic, AL/AL and the contralateral ceramic-polyethylene, AL/PE) who had THA performed between from 1981 to 1985 for osteonecrosis. Surgery was performed in patients who were average 50 years (range 30–60) old. The stem was always cemented and the same for both sides. The alumina head was 32 mm in diameter. The acetabular component was a polyethylene cup or an alumina cup and was always cemented. The mean follow-up for living patients was 35 years (range 32 to 36), and the mean follow-up for patients who had died was 23 years range 15 to 30).

14 periprosthetic fractures occurred in 252 hips after THA, representing an overall prevalence of 5.5% for hips and 11% for patients. Periprosthetic fractures increased in number with followup: 3 patients (3%) sustained fractures within 10 years of their primary implantation, 7 within 20 years, 10 within 30 years, 14 (11%) within 35 years. The risk of fracture was influenced (p=0.01) by the bearing surfaces at the time of prosthetic implantation, low (1%) for ceramic on ceramic (1/14 fractures; 1/126 hips), higher (10%) for ceramic on PE (13/14; 13/126).

When the contralateral hip of the same patient is the control, the long-term risk of periprosthetic fracture on the side with PE cup is greater (10%) than on the side with ceramic/ceramic bearing.