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The Bone & Joint Journal
Vol. 101-B, Issue 8 | Pages 910 - 914
1 Aug 2019
Kiran M Donnelly TD Armstrong C Kapoor B Kumar G Peter V

Aims

Prosthetic joint infection (PJI) and aseptic loosening in total hip arthroplasty (THA) can present with pain and osteolysis. The Musculoskeletal Infection Society (MSIS) has provided criteria for the diagnosis of PJI. The aim of our study was to analyze the utility of F18-fluorodeoxyglucose (FDG) positron emission tomography (PET) CT scan in the preoperative diagnosis of septic loosening in THA, based on the current MSIS definition of prosthetic joint infection.

Patients and Methods

A total of 130 painful unilateral cemented THAs with a mean follow-up of 5.17 years (sd 1.12) were included in this prospective study. The mean patient age was 67.5 years (sd 4.85). Preoperative evaluation with inflammatory markers, aspiration, and an F18 FDG PET scan were performed. Diagnostic utility tests were also performed, based on the MSIS criteria for PJI and three samples positive on culture alone.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_3 | Pages 8 - 8
1 Apr 2019
Kiran M Oikonomidis L AlMutani M Armstrong C Kumar G Peter V
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Background

Modularity in total hip replacement(THR) enables precise recreation of native hip biomechanics. However, there have been concerns about raised metal ion levels with increased number of interfaces. We present the 3 year results of ML taper with Kinectiv technology(MLKT), a modular neck uncemented stem. This system has modular neck options, but has only one [0] head in various diameters.

Methods

97 hips in 97 patients with a MLKT stem and Continuum socket were included in this prospective study. Harris hip score, Oxford hip scores (HHS and OHS) and yearly blood Cobalt(Co), Chromium(Cr) and Titanium(Ti) were recorded. The primary end point was revision for any reason. Paired t- test was used to assess improvement in functional scores.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_9 | Pages 32 - 32
1 May 2018
Kiran M Donnelly T Kapoor B Kumar G Peter V
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Introduction

Fluorodeoxuglucose(FDG) Positron Emission Tomography(PET) scan is used in the diagnosis of prosthetic joint infection, when the inflammatory markers and aspiration of the joint do not establish a definitive diagnosis. The aim of our study was to analyse the utility of FDG PET scan in decision making in these patients.

Methods

We performed a prospective study of patients who underwent a FDG PET scan for suspected prosthetic hip infection, between September 2013 and July 2017. We analysed the results of aspiration, culture and sensitivity, histology of intra-operative samples and inflammatory markers. Our gold standard for diagnosis of infection was 3 or more positive cultures of the same organism. Diagnostic utility statistics for FDG PET were performed.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_17 | Pages 14 - 14
1 Nov 2017
Kiran M Jariwala A Wigderowitz C
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Introduction

The trapezio-metacarpal joint (TMCJ) is subject to constant multiplanar forces and is stabilised by the bony anatomy and ligamentous structures. Ligament reconstruction can correct the hypermobility and potentially prevent osteoarthritis. Eaton and Littler proposed a surgical technique to reconstruct the volar ligamentous support of this joint. In our cadaveric biomechanical study, we aimed to evaluate the resultant effect of this technique on the mobility of the thumb metacarpal.

Materials and method

Seventeen cadaveric hands were prepared and placed on a custom-made jig. Movements at the trapeziometacarpal joint were created using weights. Static digital photographs were taken with intact anterior oblique (AOL) and ulnar collateral ligaments(UCL) and compared with those taken after sectioning these ligaments and following Eaton-Littler reconstructive technique. The photographic records were analyzed using Scion. Image™. Paired T-test was used to establish statistical significance with a p<0.05.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_17 | Pages 23 - 23
1 Nov 2017
Kiran M Lacey A Awad M Peter V
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Introduction

It is standard practice to send samples for microbiological and histological analysis during revision surgery in suspected prosthetic joint infection. The aim of our study was to analyse the utility of histology in decision making in these patients.

Methods

We performed a retrospective review of all revision hip arthroplasty patients between from September 2013 and August 2016 from the hospital database. We analysed the results of aspiration, culture and sensitivity, histology from intra-operative samples and inflammatory markers. Diagnostic utility statistics were performed.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 43 - 43
1 Jun 2017
Kiran M Shivarathre D Peter V
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There has been a significant decline in the use of metal-on-metal (MoM) bearings due to concerns regarding adverse reaction to metal debris (ARMD). The Medicines and Healthcare products Regulatory Agency (MHRA) recommends annual follow-up for life with blood Cobalt (Co) and Chromium (Cr) ion level measurement in all MoM THRs with femoral head size greater than or equal to 36mm. We present the serial ten year serum Co and Cr levels in a cohort of large head MoM THRs and analyse the utility of measuring serum ions levels annually.

All patients who underwent unilateral large head MoM THR between January 2004 and December 2006 were included in this prospective study. Annual serum Co and Cr measurements were measured. Clinical case notes and radiographs were reviewed for failure, revision surgery and the occurrence of ARMD. Mann Whitney test was used to analyse changes in serum Co and Cr levels. Receiver Operating Characteristic (ROC) curve was plotted based on their sensitivity and specificity to detect ARMD.

256 patients were included. There was a significant increase in serum ion values in the first two years. After 7 years, there was no significant change in Co values(p=0.78) and there was a decline in Cr value after 9 years(p<0.001). With 7 µg/l as the cut-off value, the sensitivity and specificity of Co was 82.1% and 65.5% and of Cr was 53.5% and 91.3%.

Annual follow-up of patients with MoM THR based on the MHRA guideline to obtain serum metal ion levels can cost about £9 million/year. Our study noted poor discriminatory ability for both Co and Cr values in the ROC curve. There is poor correlation between serum metal ion levels and the occurrence of ARMD on MARS MRI. Based on our results we find limited utility in doing ion levels after 7 years in asymptomatic patients.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_11 | Pages 14 - 14
1 Jun 2017
Luo W Kiran M Perry D
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Purpose

To assess the use of radiographic measurement compared to descriptive classification in the evaluation of Perthes' disease.

Method

Fifteen consultant Paediatric Orthopaedic surgeons, members of the BOSS Collaborative from different UK centres, were asked to rate a series of 100 healed AP radiographs of hips affected by Perthes' Disease from the Liverpool Perthes' Disease Register using the Stulberg' s grading. Two independent observers categorised roundness error using Digitimizer™ software. Kappa scores were used to determine the inter-observer concordance amongst the 15 observers for Stulberg classification. Lin concordance was used to determine roundness error assessment. The relationship between the two outcomes was explored statistically and graphically; considering the mean Stulberg grade recorded by the 15 observers as a continuous outcome.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_14 | Pages 11 - 11
1 Jul 2016
Kiran M Mohamed S Newton A George H Bruce C
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Tropical pyomyosistis is an uncommon condition in the United Kingdom. Early diagnosis and appropriate treatment are crucial for a good outcome. We had seen 13 cases in our previously published series from 1998 to 2009. This is an update showing a significantly increased incidence from 2010 to 2016.

A retrospective review of all cases of pelvic pyomyositis in our centre from January 2010 to April 2016 was undertaken from case notes and radiology reports. All children with clinical and radiographic evidence of pyomyositis were included. Since our previous publication we had changed our practice to get an MRI scan in all children who presented with a limp, fever and raised inflammatory markers, and had no effusion in the hip ultrasound scan.

We identified 24 children with a mean age of 7 years (range, 1 week to 14 years). MSSA (Methicillin-Sensitive Staphylococcus aureus) was the most common cultured organism (n=8). Median hospital stay was 9 days (3 to 12). Obturator internus was the most common muscle affected. All patients had appropriate antibiotics with 2 patients requiring surgical drainage of abscesses. The majority of children (n=22) showed a complete recovery with antibiotics only.

Incidence of pyomyositis has increased dramatically in our population and early diagnosis can result in a good outcome. We recommend MRI scan in all patients who present with a clinical picture of septic arthritis of the hip but with no effusion.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_14 | Pages 15 - 15
1 Jul 2016
Kiran M Chakkalakumbil S George H Walton R Garg N Bruce C
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The aim of this study is to discuss the results of intramedullary devices in the management of paediatric radial neck fractures and to suggest methods to avoid the pitfalls of the technique.

30 patients with isolated Judet III and IV fractures were included in this retrospective study. The method of reduction was reviewed. The final results were graded using the Metaizeau functional scoring system and Oxford Elbow score.

Intramedullary K wires were used in 10 patients and blunt tipped TENS nails in 20 patients. The complications seen were radiocapitellar joint penetration-6 cases at mean 4.87 weeks, redisplacement − 6, radial epiphyseal sclerosis − 5 and heterotopic ossification − 1 case. The functional result was good to excellent in 24 of 30 cases(80%). The mean Oxford Elbow score was 44.32. The mean follow-up was 40.11 months.

Intramedullary K wires may result in radiocapitellar joint penetration. Blunt tipped devices should not be used as purely fixation devices as they may not prevent redisplacement. Minimal redisplacement does not affect the functional outcome.

Regular follow-up until atleast 6 weeks is essential. Patients who have a Judet IV fracture and need open reduction should be closely followed up and given a guarded prognosis.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_14 | Pages 19 - 19
1 Jul 2016
Kiran M Johnstone L Jariwala A
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Orthopaedics has been earmarked as one of the specialties that could make significant savings in the National Health Service. A large number of young adults are receiving total hip replacements and there has been a trend towards using uncemented implants. We describe the clinical and functional results at minimum 19 year follow up of cemented total hip replacements in patients under the age of fifty-five in our health region between 1990 and 1997.

104 cemented THRs performed in 100 patients under 55 years were included in this study. The follow-up data had been collected prospectively in the University database. 88.46% hips showed good to excellent results at final follow-up with a mean Harris hip score of 87.9±8.64. Revision was performed in 2 hips (1.92%), one for aseptic acetabular loosening and the other for late haematogenous infection. Probable radiological loosening was seen in 14 acetabular components (14.89%) and 4 femoral components (4.25%) at final follow-up. The mean rate of acetabular wear was 0.12mm/year and was not influenced by gender or diagnosis. The mean follow-up was 21.68±2.11 years (range 19 to 26 years) and the survivorship at 19 years was 98.07%.

The GIRFT report looked at the economic aspect of implant selection and found that the cost of uncemented implants was almost double that of the cemented implants. Savings of atleast £10 million a year can be made if cemented implants were used. We recommend that in a publically funded health system like the NHS, cemented implants can be used in patients under 55 with good long term functional outcomes and large savings in the healthcare costs.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_13 | Pages 18 - 18
1 Jun 2016
Kiran M Jariwala A Wigderowitz C
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The aim of this study was to compare the results of Matti-Russe (MR) procedure and interpositional techniques (IT) in the management of scaphoid non-union.

50 scaphoid non-unions were included in this retrospective study. Demographics, initial management of fracture, location of non-union, time to surgery, procedure done and immobilisation time were recorded. Radiographs were analysed for union and deformity correction. Functional outcome was analysed using the Herbert's grading system.

The mean age and time to surgery were 26.7 years and 15.9 months. Twenty-one patients had the MR procedure and twenty-nine patients had interpositional procedures with internal fixation. DISI was present in 17 patients. The mean postoperative change in the scapholunate angle with the MR procedure was 7.9° compared to 8.0° (p>0.05) for the IT procedures. Union rate was 76% for both procedures. The mean follow-up was 9.9 months. Functional results were Herbert 0 or 1 in 42 cases.

The only significant prognostic variables were location of non-union and time to surgery. Similar deformity correction was achieved using both IT and MP procedures. MP procedure can be used in the management of scaphoid non-union even in the presence of deformity with good functional results.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_10 | Pages 17 - 17
1 Oct 2015
Kiran M Arvinte D Sood M
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Introduction

The aim is to study the outcome of a consecutive single surgeon's series using the ReCap Hip resurfacing arthroplasty (HRA) system.

Methods

This is an ongoing prospective study. HRA was performed in active males under 65 years with good bone quality and in pre-menopausal females with adequate bone density proven by a DEXA scan. Radiographs were analysed for acetabular inclination, notching, neck thinning and change in implant position. Pre-op and follow-up Oxford hip and UCLA scores were recorded.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_10 | Pages 23 - 23
1 Oct 2015
Jariwala A Kiran M Parthasarathy A Johnston L
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Background of study

Numbness around the surgical scar can be a source of discomfort in patients undergoing Total Knee Arthroplasty (TKA). Literature reports wide variation in its prevalence. The consequence of numbness on the functional outcome is not clear. We aimed to investigate the prevalence of numbness, along with factors affecting it, and assess its effect on the outcome of TKA.

Materials and methods

258 patients who underwent TKA were included in the prospective cross sectional patient reported outcome measure (PROM) study. Demographic details, approach, length of incision, and the pre-operative and one year post-operative Knee Society Score (KSS) were recorded. A Dundee numbness classification was developed and used for the assessment and localization of numbness using e-Ruler® and Matlab® computer software.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_18 | Pages 21 - 21
1 Dec 2014
Pujar S Kiran M Jariwala A Wigderowitz C
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Background

The optimal treatment for symptomatic elbow osteoarthritis remains debatable especially in patients still involved in heavy manual work. The Outerbridge-Kashiwagi (OK) procedure has been used when simple measures fail. The aim of this study is to analyse the results of the OK procedure in patients with symptomatic osteoarthritis.

Methods

Twenty-two patients were included in the study. The male:female ratio was 18:4. The mean age was 60 years with mean follow-up of 38 months (24–60 months). 17 were manual workers, 3 involved in sports activities and 2 non-manual workers. All patients were assessed using Mayo Elbow Performance Index Score system. Preoperative radiological assessment showed osteophytes around olecranon and coronoid process and joint space narrowing in radio-humeral articulationin all cases.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_20 | Pages 4 - 4
1 Apr 2013
Kiran M Jariwala A Wigderowitz C
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Introduction

The aim of this study is to analyse the effect of the degree of coverage of the Total Elbow implant with cement and the significance of cementation index as a predictor of failure.

Material/methods

Fifty elbows in forty seven patients who had undergone the Coonrad-Morrey TER were included in the study. The post-operative radiographs were evaluated for the cementation index. Failures and revisions were documented. Statistical analysis was done to evaluate the cementation index as a predictor of failure.