The purpose of this study was to develop a quality appraisal tool for the assessment of laboratory basic science biomechanical studies. Materials andScore development comprised of the following phases: item identification/development, item reduction, content/face/criterion validity, weighting, test-retest reliability and internal consistency. For item identification/development, the panel was asked to independently list criteria and factors they considered important for cadaver study and generate items that should be used to appraise cadaver study quality. For content validity, the content validity ratio (CVR) was calculated. The minimum accepted content validity index (CVI) was set to 0.85. For weighting, equal weight for each item was 6.7% [15 items]. Based on these figures the panel was asked to either upscale or downscale the weight for each item ensuring that the final sum for all items was 100%. Face validity was assessed by each panel member using a Likert scale from 1–7. Strong face validity was defined as a mean score of >5. Test-retest reliability was assessed using 10 randomly selected studies. Criterion validity was assessed using the QUACS scale as standard. Internal consistency was assessed using Cronbach's alpha. Five items reached a CVI of 1 and 10 items a CVI of 0.875. For weighting five items reached a final weight of 10% and ten items 5%. The mean score for face validity was 5.6. Test-retest reliability ranged from 0.78–1.00 with 9 items reaching a perfect score. Criterion validity was 0.76 and considered to be strong. Cronbach's alpha was calculated to be 0.71 indicating acceptable internal consistency. The new proposed quality score for basic science studies consists of 15 items and has been shown to be reliable, valid and of acceptable internal consistency. It is suggested that this score should be utilised when assessing basic science studies.
The posterior compartments of the knee are currently accessed arthroscopically through anterior, posteromedial or posterolateral portals. A direct posterior portal to access the posterior compartments has been overlooked due to a perceived high-risk of injury to the popliteal neurovascular structures. Therefore, this study aimed to investigate the safety and accessibility of a direct posterior portal into the knee. This cross-sectional study comprised a sample of 95 formalin-embalmed cadaveric knees and 9 fresh-frozen knees. Cannulas were inserted into the knees, 16mm from the vertical plane between the medial epicondyle of the femur and medial condyle of the tibia and 8 and 14mm (females and males respectively) from the vertical plane connecting the lateral femoral epicondyle and lateral tibial condyle. Landmarks were identified in full extension and cannula insertion was completed with the formalin-embalmed knees in full extension and the fresh-frozen in 90-degree flexion. Posterior aspects of the knees were dissected from superficial to deep, to assess potential damage caused by cannula insertion. Incidence of neurovascular damage was 9.6% (n=10); 0.96% medial cannula and 8.7% lateral cannula. The medial cannula damaged one small saphenous vein (SSV) in a male specimen. The lateral cannula damaged one SSV, 7 common fibular nerves (CFN) and both CFN and lateral cutaneous sural nerve in one specimen. All incidences of damage occurred in formalin-embalmed knees. The posterior horns of the menisci were accessible in all specimens. A medial-lying direct posterior portal into the knee is safe in 99% of occurrences. The lateral-lying direct posterior portal is of high risk to the CFN.
This study aimed to describe the morphology of the coracoid process and determine the frequency of commonly observed patterns. The second purpose was to determine the location of inferior tunnel exit with superior based tunnel drilling and the superior tunnel exit with inferior based tunnel drilling. A sample of 100 dry scapulae for the morphology aspect and 52 cadaveric embalmed shoulders for tunnel drilling were used. The coracoid process was described qualitatively and categorized into 6 different shapes. A transcoracoid tunnel was drilled at the centre of the base. Twenty-six shoulders were used for the superior-inferior tunnel drilling approach and 26 for the inferior-superior tunnel drilling approach. The distances to the margins of the coracoid process, from both the entry and exit points of the tunnel, were measured. Eight coracoid processes were of convex shape, 31 of hooked shape, 18 of irregular shape, 18 of narrow shape, 25 of straight shape, and 13 of wide shape. The mean difference for the distances between superior entry and inferior exit from the apex was Powered by Editorial Manager® and ProduXion Manager® from Aries Systems Corporation 3.65+3.51mm (p=0.002); 1.57+2.27mm for the lateral border (p=0.40) and 5.53+3.45mm for the medial border (p=0.001). The mean difference for the distances between inferior entry and superior exit from the apex was 16.95+3.11mm (p=0.0001); 6.51+3.2mm for the lateral border (p=0.40) and 1.03+2.32 mm for the medial border (p=0.045). The most common coracoid process shape observed was a hooked pattern. Both superior to inferior and inferior to superior tunnel drilling directed the tunnel from a more anterior and medial entry to a posterior-lateral exit. Superior to inferior drilling resulted in a more posteriorly angled tunnel. With inferior to superior tunnel drilling cortical breaks were observed at the inferior and medial margin of the tunnel.
Knee arthroscopy is typically approached from the anterior, posteromedial and posterolateral portals. Access to the posterior compartments through these portals can cause iatrogenic cartilage damage and create difficulties in viewing the structures of the posterior compartments. The purpose of this study was to assess the feasibility of needle arthroscopy using direct posterior portals as both working and visualising portals. For workability, the needle scope was inserted advanced from anterior between the cruciate ligament bundle and the lateral wall of the medial femoral condyle until the posterior compartments were visualised. For visualisation, direct postero-lateral and -medial portals were established. The technique was performed in 9 knees by two experienced researchers. Workability and instrumentation of the posteromedial compartment and meniscus was achieved in 56%. The posterior horns could not be visualised in four specimens as the straight lens could not provide a more medial field of view. Visualisation from the direct medial posterior portal allowed a clear view of the medial meniscus, femoral condyle and posterior cruciate ligament in all specimens. Workability and instrumentation of the posterolateral compartment was not possible with the needle scope. Direct posterior approaches for the posteromedial compartment access are challenging with the current needle scope options and could only be achieved in over 50%. The postero-lateral compartment was not accessible. An angled lens or a flexible Needle scope would be better suited for developing this technique further.
Imageless navigation has improved the accuracy of acetabular cup placement but relies on manual identification of pelvic anatomy. Thick soft tissues in obese patients could obscure these landmarks and result in large variances of cup placement. The purpose of this study was to investigate the relationship between BMI, soft tissue thickness, navigated cup and final post-operative cup position. Thirty patients with an average age of 66.5 years underwent primary navigated THA. Final intra-operative cup position was recorded. Soft tissue thickness and final post-operative cup alignment were measured on a multi-slice pelvis CT scan.Purpose:
Methods:
Correct placement of the acetabular cup is a crucial step in hip replacement to achieve a satisfactory result and remains a challenge with free hand techniques. Imageless navigation may provide a viable alternative to freehand technique and improve placement significantly. The purpose of this project was to assess and validate intra-operative placement values as displayed by an imageless navigation system to postoperative measurement of cup position using high resolution CT scans. Thirty-two subjects who underwent primary hip joint arthroplasty using imageless navigation were included. The average age was 66.5 years (range 32–87). 23 non-cemented and 9 cemented acetabular cups were implanted. The desired position for the cup was 45 degrees of inversion and 15 degrees of anteversion. A pelvic CT scan using a multi-slice CT was used to assess the position of the cup radiographically.Purpose:
Methods:
Gait analysis is an important tool to measure function following total knee replacement. It is currently unknown whether there is a correlation between subjective and objective outcome. The purpose of this study was to analyse relationships between subjective outcome scores and kinematic and kinetic data. 25 consecutive patients (15 males, 10 females) were selected (mean age 68 years, BMI 31.8). All subjects were tested a minimum of 24 months following total knee replacement. SF12, Oxford knee score, knee society and KOOS scores were collected. Muscle strength was assessed using a Biodex dynamometer and symmetry indices were analysed. A timed up and go test and KT2000 measurements were performed.Introduction:
Methods:
The aim of this study was to investigate the outcome after ACL reconstruction between a group of patients receiving a standardized supervised physiotherapy guided rehabilitation program and a group of patients who followed an un-supervised, home-based rehabilitation program. 40 patients with isolated anterior cruciate ligament injuries were allocated to either a supervised physiotherapy intervention group or home-based exercise group. Patients were investigated by an independent examiner pre-operative, 3, 6, 9 and 12 months post-surgery using the following outcome measures: Lysholm Score and Tegner Activity Scale, functional hopping tests, isometric and isokinetic strength assessments.Background:
Methods:
A higher posterior tibial slope can potentially result in kinetic and kinematic changes of the knee. These changes may influence knee functionality in ACL-deficient and ACL-reconstructed subjects. The purpose of this study was to investigate the relationship between knee functionality and posterior tibial slope in ACL-deficient and ACL-reconstructed subjects. Subjects with isolated ACL injuries and subjects who underwent ACL-reconstruction with bone-patella-bone-tendon (BPTP) between 18 and 24 months post surgery were included in the study. Posterior tibial slope was measured on a lateral radiograph using the posterior tibial cortex as a reference. The Cincinnati scoring system was used to assess knee functionality.Purpose:
Methods:
Malpositioning of the acetabular cup component in total hip arthroplasty can result in increased wear, early nonseptic loosening and is the most common cause of dislocation. Previous research has defined a safe zone with an inclination of 40±10 degrees and anteversion of 15±10 degrees. The purpose of this study was to compare cup placement using imageless navigation to a matched control group using CT based measurements. 30 patients receiving a primary hip replacement were included. Alignment of the implant is based on the acquisition of landmarks (ASIS and pubic tubercle) and placement of tracking pins into the ASIS. The target position for all patients was 45 degrees of inclination and 15 degrees of anteversion. A multi-slice CT scan was used to assess cup position.Purpose:
Methods:
Given their role in reducing anterior tibial translation, the recruitment patterns and viscoelastic properties of the hamstring muscles have been implicated as neuromuscular factors contributing to the ACL gender bias. Nevertheless, it is uncertain whether patterns of aberration displayed by the female neuromuscular system significantly alters the antagonist moments generated by the hamstrings during maximal effort knee extension. The purpose of the current study was to examine the effect of gender on hamstring antagonist moments in order to explain the higher ACL injury rates in females. Eleven females (age 30.6 ± 10.1 years, mass 62.1± 6.9 kg, height 165.9 ± 4.6) and 11 males (age 29.0 ± 8.2 years, mass 78.6± 14.4 kg, height 178.5± 6.2) were recruited as subjects. Surface electrodes were placed over the semitendinosus (ST) and biceps femoris (BF) muscles of the dominant and non-dominant limbs. Each subject performed two sets of five maximal extension and flexion repetitions at 180-1. EMG, isokinetic torque and knee displacement data were sampled at 1000Hz using an AMLAB data acquisition system. Average hamstring antagonist torque data across the range of knee flexion for female subjects was significantly higher (%Diff=24%) than for the male control subject. Statistical analyses revealed a significant main effect of gender (F = 4.802; p = 0.036). Given that females possess a more compliant ACL and hamstring musculature, compared with their male counterparts, an augmented hamstring antagonist may represent a compensatory neuromuscular strategy to increase knee stiffness to control tibial translation and ACL strain. The results of this project suggest that it is unlikely that gender-related differences in hamstring antagonist torque is one of the predisposing factors contributing to the higher ACL injury rates in females.
Anthropometric anatomical factors may influence mechanical and functional stability of joints. An increased posterior tibial slope places the anterior cruciate ligament at a theroretical biomechanical disadvantage. An increased posterior tibial slope can potentially alter forces during landing tasks by either increasing anterior tibial translation and/or ACL loading. The purpose of this study is to investigate the relationship between posterior tibial slope and anterior cruciate ligament injuries. It is hypothesised that subjects with an ACL injury have an increased posterior tibial slope compared to a normal population. Posterior tibial slope in 211 patients (154 male, 57 female), aged 15–49, who underwent anterior cruciate ligament reconstruction was measured using the posterior tibial cortex as reference. A matched control group was used for comparison. The average posterior tibial slope in the ACLR population was 6.1 degrees, whilst the control group had average values of 5.4 degrees. This finding nearly reached statistical significance (p=0.057). In the male population, average values were 5.5 degrees in the ACLR group and 5.9 in the control group. This was not significant (p=0.21). However, there was a significant difference (p=0.04) in the female group. ACLR females had higher values 6.5 degrees whereas the control group had average values of 5.2 degrees. Increased posterior tibial slope decreases the inclination of the ACL and potentially decreases vector force during dynamic tasks. We could not confirm the results of previous studies demonstrating an increased degree of posterior tibial slope in ACL injured patients. However, we demonstrated a significant difference in tibial slope in females. Based on our results, an increased posterior tibial slope is not a risk factor in males but possibly contributes to ACL injuries in females. Increased posterior tibial slope may be one of the reasons why females have a higher incidence of ACL injuries.
Previous research has shown that tunnel placement is critical in ACL reconstruction. The ultimate position of both the femoral and tibial tunnel determines knee kinematics and overall function of the knee post surgery. As with all techniques there is a definite learning curve for the arthroscopic technique. However, the effect of the learning curve on tunnel placement has been studied sparsely. The purpose of this project therefore is to investigate the effect of the learning curve on tunnel placement. Postoperative radiographs of the first 200 anterior cruciate reconstructions with bone-tendon-bone patella tendon of a single orthopaedic surgeon performed during the first four years of independent practice were analysed for tunnel placement. Radiographs were digitalised and imported into a CAD program. Tunnel placement both femoral and tibial antero-posterior and sagittal was assessed using Sommer's criteria. A rating scale was developed to assess overall placement. A total of 100 points indicated perfect placement. A maximum of 30 points each were allocated for sagittal femoral and tibial placement and a maximum of 20 points each were allocated for coronal placement. Tunnel placement scores improved from 66 for the first 25 procedures to 87 for the last 25 procedures. Sagittal femoral placement (zone 1–4 with zone 1 being the preferred zone of placement) improved from an average of 1.44 to 1.08. Sagittal tibial placement (45% from anterior border of tibia) did not change significantly and remained between 42.82 t0 44.76%. Coronal femoral placement (between 10:00–11:00 o'clock for the right knee and 1:00–2:00 for the left knee) ranged from 10.45–11.15 and 12:45-1:15 o'clock respectively. This finding may be related to the transtibial tibial technique used to place the femoral tunnel. Coronal tibial placement (45% from medial tibial border) ranged from 45-46.58%. Correct placement of the femoral and tibial bone tunnels is important for a successful reconstruction of the anterior cruciate ligament (ACL). This study demonstrated a definitive learning curve and steady improvement of tunnel placement. Whilst there was no significant improvement in sagittal placement, overall placement improved significantly.
A higher posterior tibial slope can potentially result in kinetic and kinematic changes of the knee. These changes may influence knee functionality in ACL-deficient and ACL-reconstructed subjects. The purpose of this study is to investigate the relationship between knee functionality and posterior tibial slope in ACL-deficient and ACL-reconstructed subjects. Subjects with isolated ACL injuries and subjects who underwent ACL- reconstruction with BPTP between 18 and 24 months post surgery were included in the study. Posterior tibial slope was measured on a lateral radiograph using the posterior tibial cortex as a reference. The Cincinnati scoring system was used to assess knee functionality. Frty-four ACL-deficient patients with a mean age of 26.6 years, and 44 ACL-reconstructed patients with a mean age of 27.2 (25–49) years were included. The posterior tibial slope in the ACL-deficient group averaged 6.10±3.57 degrees (range 0–17 degrees) and 7.20±4.49 degrees (range 0–17) in the ACL-reconstructed group. The mean Cincinnati score in the ACL-deficient subject was 62.0±14.5 and 89.3±9.5 in the ACL-reconstructed subject. There was a moderate but non-significant correlation (r=0.47) between knee functionality and slope in the ACL-deficient subject. By dividing posterior tibial slope into intervals, a strong significant correlation (r=0.91, p=0.01) was observed between knee functionality and slope. There was a weak but non-significant correlation (r=0.24) between knee functionality and slope in the ACL-reconstructed patient. Dividing posterior tibial slope into intervals (0-4, 5-9, >10) a strong and significant correlation (r=0.96, p=0.0001) was observed between knee functionality and slope. The results of this study suggest that subjects with a higher posterior tibial slope have higher knee functionality. This is in contrast to previous research.
Estrogen fluctuations have been implicated in the soft tissue injury gender-bias due to the hormones effect on the viscoelastic properties. The isolated effect of estrogen on the mechanical behaviour of human tendon is unknown. The purpose of this study was to elucidate the effect of circulating levels of estrogen on the strain properties of the human Achilles tendon. Twenty females (18–35 years) who were using the pill together with 20 matched, non-pill users, participated in this study. Non-pill users were tested at the time of lowest (menstruation) and highest (ovulation) estrogen whilst pill users, who exhibited constant and attenuated estrogen levels, were tested at menstruation and two weeks later. At each test session, maximal isometric plantarflexion efforts were performed on a calf-raise apparatus whilst synchronous real-time ultrasonography of the triceps surae aponeurosis was recorded. Connective tissue length (Lo) of the triceps surae complex was measured and tendon strain was calculated by dividing aponeurosis displacement during plantarflexion by Lo. Repeated measures ANOVA revealed a significant (p < 0.05) main effect of subject group with significantly higher Achilles strain rates (16.1%) in the non-pill users compared to the pill users. Augmented Achilles tendon strain was associated with higher average estrogen levels in non-pill users. Those results suggest that higher estrogen levels diminish the joint stabilising capacity of the triceps surae musculotendinous unit and may alter the energy storage capacity of the Achilles tendon during stretch-shorten cycle activities. This may result in a higher incidence of injuries during periods of high estrogen concentration.
A number of validated knee outcome rating scales are used to assess knee function in the ACL-deficient and ACL-reconstructed knee. These scores use a numeric system to rate findings such as pain, swelling, subjective assessment of function and level of activity. However, it is unknown whether there is a correlation between the outcome rating scales and whether they can be used interchangeably. The aim of this study was to investigate the correlation between the four commonly used outcome rating scales (Lysholm, IKDC, Cincinnati and Tegner). Inclusion criteria included physically active patients between the age of 18 and 35 years with isolated ACL injuries. A power calculation for sample size was performed. Selecting an alpha level of 0.05 and power value of 0.8, 24 ACL- deficient and 24 ACL-reconstructed subjects were needed to achieve adequate statistical power. Statistical analysis included the calculation of means and standard deviations for the dependant variables. Pearson's product moment correlation coefficients were used to establish the strength of the relationships. Forty-four ACL-deficient and 24 ACL reconstructed subjects (mean age 27.0, range 16–49), with a minimum of 12 months post surgery, completed the tests. Pre-operatively, strong significant correlations (r=0.53-0.74, p=0.0001-0.001) between IKDC and the other scoring systems (Cinncinati, Lysholm and Tegner) were observed. The Lysholm score was significantly correlated to IKDC (r=0.74, p=0.0001) and Cinncinati (r=0.60, p=0.001) scores. Non-significant moderate correlations were observed between Lysholm and Tegner (r=0.38, p=0.17) and Cinncinati and Tegner (r=0.36, p=0.18) scores. Post-operatively all scores were strongly related (r=0.61- 0.93). However, only the relationships between Lysholm and IKDC score (p=0.001) and IKDC and Cinncinati score (p=0.01) reached statistical significance. The results of this study indicate that the commonly used rating scales produce interchangeable results in the ACL-deficient patient. In the ACL-reconstructed patient, knee scoring systems seem to measure different aspects of physical activity, physical disability and subjective patient satisfaction—all of which are not interchangeable. As such, the classification of results may vary and may explain the findings.
Epidemiologic studies project an increase of hip fractures worldwide. They are an important cause of morbidity and mortality in the elderly and represent an increasing burden on a country's health service. The aim of the study was to evaluate the mortality of hip fractures admitted to a regional hospital in Australia and calculate the relative risk ratio of morbidity variables on mortality. This retrospective review included all patients admitted from 2003 to 2008 to a regional Queensland hospital with a hip fracture. The relative risk ratio for the probability of death was calculated for the following variables: previous mobility (independent, home with help, nursing home), type of treatment (hemiarthroplasty, ORIF, DHS/Nail, total hip arthroplasty, conservative), ASA, comorbidities (dementia, hypertension, cardiac, respiratory, renal, previous hip fractures, diabetes), pre-operative haemoglobin, BUN ratio, length of stay, operative time, anaesthetic time and type (general, spinal) and, gender. A total of 211 patients (136 female, 75 male) with an average age of 79.1 years were admitted. Seventy-six patients died during the specified interval. The average 30 day mortality was 6.2% and the average time of survival was 318 days. The relative risk of death was above one for the following variables: female gender 1,16; nursing home 1,11; more than 1 comorbidity 1,38; more than 4 comorbidities 1,78; dementia 1,12; diabetes 1,3; hypertension 1,35, previous fractures 1,43; ASA 4 1,5; operating time more than 120 minutes 7,4; length of stay more than 20 days 2,16, BUN ratio>0.1 1,38 and BUN ration<0.04 1,78. This retrospective project identified a number of variables influencing mortality of hip fractures. These results demonstrate that the relative risk substantially increases with length of surgical time, length of hospital stay in excess of 20 days and more than four associated comorbidities.
Primary wound closure in open tibial fractures has not been recommended. Traditionally initial debridement with fracture stabilisation and delayed wound closure was the accepted treatment. However this practice was developed before the use of prophylactic intravenous antibiotics and improved techniques for fracture stabilisation. Studies suggest that infections are not caused by the initial contamination but the organisms acquired in the hospital. Subsequent primary wound closure after adequate wound care and fracture stabilisation should be a safe concept and should not increase the rate of complications. In a retrospective study we analysed 95 patients with open tibial fractures Gustilo-Anderson Type 1-3a treated at two different teaching hospitals with primary fracture stabilisation and delayed wound closure as group I and primary fracture stabilisation and primary wound closure as group II. Exclusion criteria to the study were the following conditions: Grade 3b and 3c fractures, polytrauma, other fractures, significant medical history, previous surgery 6 months prior to admission. In group I 46 patients (38 males, 8 females) with a mean age of 30.2 years (16-56) were included. 19 sustained Grade 1 open, 16 Grade 2 open, 4 Grade 3a open and 7 gunshot fractures to the shaft of the tibia. In group II 49 patients (36 males, 13 females) with a mean age of 33.4 (18-69) were included. 19 sustained Grade 1 open, 19 Grade 2 open, 3 Grade 3a open and 8 gunshot fractures. The mean follow-up in group 1 was 11.5 (9-18) and 11.7 (8-16) months. The criteria for post-operative infection were clinical/radiological.Introduction
Material/methods
The level of hamstring antagonist activation is thought to be related to knee functionality following anterior cruciate ligament (ACL) injury/surgery as pronounced co-activation can control anterior tibial translation (ATT). The purpose of this study was to examine relationships between knee functionality and hamstring antagonist activation during isokinetic knee extension in ACL deficient (ACLD) and ACL reconstructed (ACLR) patients. Knee functionality was rated using the Cincinnati Knee Rating System for the involved limb of 10 chronic, functional ACLD patients and 27 ACLR patients (14 using a patella tendon (PT) graft and 13 using a semitendinosus/gracilis tendon (STGT) graft). Each subject also performed maximal effort isokinetic knee extension and flexion at 180°. s-1 for the involved limb with electromyographic (EMG) electrodes attached to the semitendinosus (ST) and biceps femoris (BF) muscles. Antagonist activity of the ST and BF muscles was calculated in 10° intervals between 80-10° knee flexion. For the ACLD group, Pearson product moment correlations revealed significant (p<0.05) moderate, positive relationships between knee functionality and ST and BF antagonist activity across the majority of the knee flexion intervals. For both ACLR groups, several significant (p<0.05) moderate, negative associations were found between ST and BF antagonist activity and knee functionality. Amplified hamstring antagonist activity in ACLD patients at flexion angles representative of those at footstrike and deceleration improves knee functionality as increased crossbridge formation increases hamstring stiffness and decreases ATT. Lower-level hamstring activation is sufficient to unload the ACL graft and improve knee functionality in ACLR patients.
