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Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_17 | Pages 88 - 88
1 Dec 2018
SURGICAL SITE INFECTIONS FOLLOWING IMPLANT REMOVAL: THE EFFECT OF ANTIBIOTIC PROPHYLAXIS. RESULTS OF THE WIFI TRIAL
Sanders F Backes M Dingemans S Goslings C Schepers T
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Aim

Following clean (class I, not contaminated) surgical procedures, the rate of surgical site infection (SSI) should be less than approximately 2%. However, an infection rate of 12.2% has been reported following removal of orthopedic implants used for treatment of fractures below the knee. The objective of this trial was to evaluate the effect of a single dose of preoperative antibiotic prophylaxis on the incidence of SSIs following removal of orthopedic implants used for treatment of fractures below the knee.

Method

This multicenter, double-blind, randomized clinical trial included 500 patients from 19 hospitals with a follow-up of 6 months. Eligible were patients aged 18 to 75 years with previous surgical treatment for fractures below the knee who were undergoing removal of orthopedic implants. Exclusion criteria were an active infection or fistula, antibiotic treatment, reimplantation of osteosynthesis material in the same session, allergy for cephalosporins, known kidney disease, immunosuppressant use, or pregnancy. The intervention was a single preoperative intravenous dose of 1000 mg of cefazolin (cefazolin group, n = 228) or sodium chloride (0.9%; saline group, n = 242). Primary outcome was SSI within 30 days as measured by the criteria from the US Centers for Disease Control and Prevention. Secondary outcome measures were functional outcome, health-related quality of life, and patient satisfaction.

Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 164 - 164
1 May 2011
COMPARISON OF COMPUTED TOMOGRAPHY AND MAGNETIC RESONANCE IMAGING IN TRIAGE OF SUSPECTED SCAPHOID FRACTURES
Mallee W Doornberg J Ring D Van Dijk N Maas M Goslings C
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Background: This study tested the null hypothesis that computed tomography (CT) and magnetic resonance imaging (MRI) have the same diagnostic performance characteristics for triage of suspected scaphoid fractures.

Methods: Thirty-four consecutive patients with a suspected scaphoid fracture (post-injury tenderness of the scaphoid and normal radiographs) underwent CT and MRI within ten days after trauma. CT-reconstructions were made in planes defined by the long axis of the scaphoid. The reference standard for a true fracture of the scaphoid was 6-week follow-up radiographs in four views, based on current literature. A panel including surgeons and radiologists came to a consensus diagnosis for each type of imaging considered in a randomized and blinded fashion, independent of the other types of imaging. We calculated sensitivity, specificity and accuracy as well as positive (PPV) and negative predictive values (NPV) for both imaging modalities.

Results: According to the reference standard there were six true fractures of the scaphoid (prevalence 18%). CT diagnosed fracture of the scaphoid in five patients (15%), with one false positive, two false negative and four true positive results. MRI diagnosed a fracture in seven patients (21%), with three false positive, two false negative and four true positive results. Sensitivity, specificity and accuracy for CT were 67%, 96% and 91%; and for MRI 67%, 89% and 85% respectively. According to the McNemar test for paired binary data for each imaging modality these differences were not significant. The positive predictive values using Bayes’ formula were 76% for CT and 54% for MRI. Negative predictive values were 94% for CT and 93% for MRI.

Conclusions: CT and MRI had comparable diagnostic characteristics. Both were subject to both false positive and false negative interpretations. They were better to rule out a fracture than to rule one in. The best reference standard for a true fracture is debatable