Purpose: Medial opening wedge high tibial osteotomy (MOW-HTO) is a well-described operative method for the treatment of medial gonarthrosis in selected patients. One of the concerns with MOW-HTO is the potential delayed or nonunion across the medial gap. Traditionally, this gap was filled with autograft to facilitate union. Although alternative graft options, such as allograft, are available and have theoretical advantages over autograft, little is known about their efficacy relative to autograft in MOW-HTO. The purpose of our study was to perform a retrospective matched cohort study comparing union, re-operation and complication rates between autograft and morselized allograft as filler for the medial gap created in MOW-HTO.

Method: Forty patients who underwent MOW-HTO for sympathetic varus deformity with the use of autograft bone were matched for age, sex, body mass index, deformity and deformity correction with 40 patients who underwent the same procedure with the use of morselized bone allograft. The operative technique utilized, type of hardware fixation and rehabilitation program were similar for both groups. The primary outcome assessed was union rate as evaluated on radiographs by two independent blinded examiners. Re-operation and complication rates were assessed as secondary outcomes.

Results: A total of 73/80 patients in the study (91%) developed union, 4/80 (5%) developed nonunion, and 3/80 (4%) required early revision. The union rate was 95% and 88% in the autograft and allograft groups respectively. Three percent in the autograft and 8% in the allograft groups developed nonunion (p=0.64). Thirteen percent of the autograft patients required re-operation compared to 18% from the allograft patients (p=0.53). Complications were encountered in 28% of the autograft group and in 23% of the allograft group (p > 0.05). There was a 10% incidence of harvest site complications in the autograft group. The average operative time was 21 minutes shorter using allograft compared with using autograft (p< 0.01).

Conclusion: No statistical significant difference was demonstrated between the groups for union, re-operation rates and overall complication rates. However, the autograft group had a significant 10% incidence of harvest site complications and a statistically significant increased operative time. We conlcude that allograft is safe and efficacious to use in valgus producing MOW-HTO. Allograft avoids harvest site complications and is associated with decreased operative time when compared to autograft.

Purpose: Medial compartment osteoarthritis (OA) is the most common primary osteoarthritis of the knee, but the treatment of this disease in young patients remains controversial. High tibial osteotomy (HTO), medial unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) are all viable options. Gait analysis is one tool available to clinically assess knee kinematics, and may prove to be a good way of predicting functional outcomes of these different surgical procedures. The purpose of this study was to compare the knee kinematics, function, and quality of life of patients that underwent either a medial opening wedge HTO, UKA, or TKA for primary medial compartment OA.

Method: A matched prospective cohort study of patients between the ages of 45 and 65 who had undergone an HTO, UKA, or TKA for primary medial compartment knee OA was undertaken over a 3-year period. Primary outcome measures were gait variables, namely knee adduction moments, as measured through gait analysis. Secondary measures included quality of life (WOMAC), functional performance tests (six minute walk and timed-up-and-go), self-reported functional ability (LEFS), and general health (SF-36). Gait and functional performance tests were evaluated preoperatively and at 6, 12, and 24 months postoperatively. Self-reported quality of life, function and general health were assessed preoperatively and at 3, 6, 12, and 24 months post-operatively.

Results: Twenty HTOs, 19 medial UKAs, and 17 TKAs were matched for Kellgren-Lawrence grade of medial OA, age at surgery, and body mass index. Significant differences were observed between the three groups in step length and peak adduction moments at 24 months. Significant differences were observed in preoperative WOMAC pain and function scores, KOOS pain scores, and LEFS, but no significantly different outcome measures were observed postoperatively. Lateral Black-burne-Peel and modified Insall-Salvati ratios were the only significant radiographic differences observed between groups at 24 months.

Conclusion: To our knowledge, no gait analysis study exists comparing the medial opening wedge HTO to UKA or TKA. The results of this study suggest that most gait variables except step length and knee adduction moments are similar between groups. Moreover, except for patellar height, there were no major functional or radiographic differences between these groups.

Purpose: Simultaneous high tibial osteotomy (HTO) and anterior cruciate ligament (ACL) reconstruction has been proposed as a treatment for patients with combined medial compartment knee osteoarthritis (OA) and ACL deficiency. Although goals of surgery are to correct malalignment, decrease knee joint load and enable continued participation in sports, few prospective studies evaluating these outcomes exist. Therefore, the objective of this study was to evaluate two-year changes in frontal plane alignment, dynamic knee joint load and self-reported function during sport after simultaneous HTO and ACL reconstruction.

Method: Thirty patients with varus alignment, medial compartment knee OA and ACL deficiency have undergone medial opening wedge HTO and hamstring tendon ACL reconstruction during a single operation. Full-length, standing AP radiographs (mechanical axis angle), dynamic knee joint loads (the peak external adduction moment about the knee during self-paced walking) and the Knee Injury and Osteoarthritis Outcome Scale (KOOS) were completed before and 24 months after surgery.

Results: Based on the 14 patients currently at 24.9 ± 1.67 months postop (12 males; age = 38.5 ± 7.5 yrs.; BMI = 29.5 ± 5.6, median Kellgren and Lawrence grade = 2), mechanical axis angle decreased significantly (p< 0.005) from −6.2 ± 3.63° to 0.29±1.94°. Despite a small (0.06 ± 0.10m/s), but significant (p< 0.05), increase in self-paced walking speed after surgery, the peak knee adduction moment decreased significantly (p < 0.001) from 2.96 ± 0.61 %BW*ht to 1.58 ± 0.48 %BW*ht [mean decrease = 1.38 %BW*ht (95% CI: 0.87 – 1.89)]. Each domain of the KOOS also improved significantly (p< 0.05), with the mean sports and recreation domain increasing (p=0.001) from 26.92 ± 24.29 to 66.54 ± 28.09 [mean increase = 39.62 (95% CI: 20.09 – 51.14)]. Data from 30 patients will be available at time of presentation.

Conclusion: Two-year outcomes after simultaneous medial opening wedge HTO and ACL reconstruction suggest this treatment results in substantial improvements in alignment, knee joint load and self-reported functioning during sport.

Previous research suggests knee joint moments and muscle activity during walking are altered in patients with anterior cruciate ligament (ACL) deficiency and in patients with medial compartment knee osteoarthritis (OA). The objective of this study was to compare knee joint flexion and adduction moments and the extent of quadriceps-hamstring muscle co-contraction before and one year after combined simultaneous ACL reconstruction and high tibial osteotomy (HTO).

Eighteen patients (three females, fifteen males; age = 40 ± 8 yrs.; BMI = 28.8 ± 5.77) with ACL deficiency and OA affecting primarily the medial compartment of the knee underwent ACL reconstruction (hamstring autograft) and medial opening wedge HTO procedures during a single operation. All patients completed pre-operative and one-year postoperative quantitative gait assessments. Three-dimensional kinetic and kinematic data were collected during self-paced walking and used to calculate the peak external flexion and adduction moments about the knee. Electromyographic (EMG) activity was collected from the hamstrings and quadriceps and used to calculate the co-contraction ratio. Peak moments and co-contraction ratios were compared pre and postoperatively using paired t-tests.

The peak knee flexion moment decreased from 2.31 ± 1.14 to 1.33 ± 0.73 %BW*ht (p=0.001); mean decrease = 0.98 %BW*ht (95%CI: 0.49–1.47). The peak knee adduction moment decreased from 2.81 ± 0.62 to 1.69 ± 0.61 %BW*ht (p< 0.001); mean decrease = 1.12 %BW*ht (95% CI: 0.80–1.43). The quadriceps-hamstring co-contraction ratio decreased from 0.82 ± 0.14 to 0.72 ± 0.18 (p=0.056); mean decrease = 0.10 (95% CI: −0.003 – 0.21).

The present findings suggest that combined simultaneous ACL reconstruction and HTO significantly decreases knee flexion and adduction moments during walking. Although the present findings suggest that the quadriceps-hamstring co-contraction ratio also decreases, future research with more patients is required to confidently evaluate potential changes in muscle activity. These findings are consistent with an overall reduction in dynamic knee joint load.

The purpose of our study is to determine if hamstring autograft size can be predicted preoperatively. We will define a relationship between patient body size (BMI, height, and weight) and harvested graft size, as well as define a relationship between the preoperative MRI cross-sectional area (CSA) of hamstring tendons and harvested graft size. This information will be useful as a tool for preoperative planning in graft choice selection.

The pre-operative MRIs of one hundred and four patients (62M, 42F) who underwent ACL reconstruction using hamstring autografts were analyzed. Cross-sectional area (CSA) of the ST and G was measured on a single axial MRI image at the level of the knee joint. Combined CSA of both tendons was then compared to the diameter of the four-strand hamstring autograft measured intra-operatively. Patient BMI, height and weight was also compared to intraoperative hamstring autograft size. Linear regression analysis was then performed to define the relationship and predictive value of body size on graft diameter.

Mean graft size was 7.4mm (range 6 – 9). Average graft size for men and women, 7.6mm and 7.1mm, respectively. Predicting graft size from BMI: r= 0.29, R2= 0.08. Predicting graft size from height: r= 0.52, R2= 0.27. Predicting graft size from weight: r= 0.5, R2= 0.25. On preoperative MRI, the mean CSA of ST and G was 9.8mm2 (range 5.4 – 17.7) and 4.5mm2 (range 1.8 – 9.4) respectively, with a total CSA of 14.3mm2 (range 8.4 – 25). If the total CSA was greater than 12mm2, a graft of 7.0mm or greater could be predicted 93% of the time, with sensitivity and specificity, 78% and 76%, respectively, and a LR of 3.25.

Body size is a poor predictor of hamstring graft size in ACL reconstruction, and therefore a large patient does not always provide a large graft from harvested hamstring tendons. MRI assessment of hamstring tendons can be a useful tool for preoperative planning, providing a strong predictive value of graft size from a simple calculation.

Measures of lower limb alignment and knee joint load during walking were evaluated before and six months after medial opening wedge high tibial osteotomy (HTO) in ninety-five patients with knee medial compartment osteoarthritis (OA). Full-length standing radiographs were used to calculate the mechanical axis angle, and a gait analysis was performed to calculate the external adduction moment about the knee. Results indicated significant decreases in mechanical axis angle and peak adduction moment. These findings provide an indication of the early success of HTO in reducing the extent of lower limb malalignment and knee joint load during walking.

Medial opening wedge high tibial osteotomy (HTO) is intended to correct lower limb malalignment, resulting in decreased medial knee joint load and improved function. Due to the potential for the amount of alignment correction to change over time after surgery, frequent follow-up evaluations are encouraged.

To evaluate the early changes in lower limb alignment and medial knee joint load experienced during walking after medial opening wedge HTO.

Ninety-five patients (seventy-nine males, sixteen females; age range = 21–76 years; BMI range = 18.0–38.5) with knee joint OA affecting primarily the medial compartment underwent radiographic and gait analyses pre-surgically and six months following HTO. Full-length standing radiographs were obtained on both occasions and used to measure the static mechanical axis angle. Three-dimensional kinetic and kinematic data were also collected and combined to calculate the external knee joint adduction moment, an indirect measure of knee joint load. Paired t-tests indicated the mechanical axis angle (mean decrease = 8.32 degrees, 95% CI = 7.54,9.10) and peak external knee joint adduction moment (mean decrease = 1.61%BW*ht, 95% CI = 1.25,1.95) significantly decreased post-operatively (p< 0.001). These results indicate less varus angulation and reduced medial knee joint load following HTO.

These preliminary findings suggest that medial opening wedge HTO is an effective surgical treatment for improving alignment and reducing knee joint load.

Although these early results are promising, future research is required to determine the long-term success of this surgery in the treatment of knee OA.

Funding:

CIHR, NSERC, Arthrex Inc.