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The Bone & Joint Journal
Vol. 101-B, Issue 11 | Pages 1431 - 1437
1 Nov 2019
Harrison-Brown M Scholes C Ebrahimi M Field C Cordingley R Kerr D Farah S Kohan L

Aims

It is not known whether change in patient-reported outcome measures (PROMs) over time can be predicted by factors present at surgery, or early follow-up. The aim of this study was to identify factors associated with changes in PROM status between two-year evaluation and medium-term follow-up.

Patients and Methods

Patients undergoing Birmingham Hip Resurfacing completed the Veteran’s Rand 36 (VR-36), modified Harris Hip Score (mHHS), Tegner Activity Score, and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) at two years and a minimum of three years. A change in score was assessed against minimal clinically important difference (MCID) and patient-acceptable symptom state (PASS) thresholds. Binary logistic regression was used to assess the relationship between patient factors and deterioration in PASS status between follow-ups.


The Bone & Joint Journal
Vol. 101-B, Issue 1 | Pages 113 - 120
1 Jan 2019
Scholes CJ Ebrahimi M Farah SB Field C Cordingley R Kerr D Kohan L

Aims

The aim of this study was to report the implant survival and patient-reported outcome measures (PROMs) in a consecutive series of patients aged less than 50 years at the time of arthroplasty using the Birmingham Hip Resurfacing system (BHR), with a minimum follow-up of ten years.

Patients and Methods

A total of 226 patients with osteoarthritis of the hip, who underwent BHR and presented to a single surgeon, were included in the study. Survival of the implant was confirmed by cross-checking with the Australian Orthopaedic Association National Joint Replacement Registry. Kaplan–Meier survival curves with 95% confidence intervals (CIs) were constructed. Pre- and postoperative PROMs were compared with t-tests, and postoperative scores were compared using anchor analysis with age and gender matched normative data.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_15 | Pages 104 - 104
1 Nov 2018
Scholes C Ebrahimi M Farah S Field C Kerr D Kohan L
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The aim of this study was to report the procedure survival and patient-reported outcomes in a consecutive series of patients <50yrs at the time of hip arthroplasty with a metal-on-metal hip resurfacing system who have progressed to a minimum of 10yrs follow-up. Patients presenting for treatment of degenerative conditions of the hip electing to undergo hip resurfacing were included in a clinical registry (N=226 patients; 238 procedures). Procedure survival was confirmed by crosschecking to the Australian Orthopaedic Association National Joint Replacement Registry and comparing to all procedures by other surgeons nationwide. Kaplan-meier survival curves with 95% confidence intervals were constructed, while patient-reported outcome measures were compared with t-tests and postoperative scores assessed with anchor analysis to age and gender-matched normative data. At mean follow up of 12 years, six cases were revised with a cumulative survival rate of 96.8% (95%CI 94.2–99.4) at 15 years. Majority of revisions were early (<3yrs) and occurred in females (N=4). Patient-reported general health, disease state, hip function and activity level maintained large improvements beyond 10 years post-implantation and were equal to or exceeded age and gender-matched normative data. Metal-on-metal hip resurfacing in males and females aged <50 years at time of surgery demonstrated a high rate of cumulative survival beyond 10 years follow up. The results demonstrate excellent outcomes in this age group.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_8 | Pages 116 - 116
1 May 2016
Kohan L Field C Kerr D Farah S
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The Birmingham hip resurfacing (Smith & Nephew, Tennessee) (BHR) has been used in younger more active patients.

Aim

We report on our experience of 206 BHR procedures in patients aged 50 years or less with a minimum ten year follow-up. Clinical outcome scores, body mass index (BMI), gender and age were analysed to investigate resurfacing outcomes.

Methods

200 patients (158 males and 42 females) with an average operation age of 43.33 years (SD ±5.66) were investigated. There were 6 bilateral procedures The mean follow-up period was 12.44 years (SD ±1.71). The arthroplasties were completed between April 1999 and December 2002 by one surgeon. Data and outcome measurements were collected prospectively and analysed retrospectively. We evaluated Harris Hip Scores, Short Form-36 (SF-36v2) Scores, Tegner Activity Score Scores and McMaster Universities Osteoarthritis Index Scores (WOMAC) comparatively at preoperative, six month and yearly intervals.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_8 | Pages 117 - 117
1 May 2016
Kohan L Kerr D Farah S Field C Nguyen D
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Aim

Adverse tissue reactions have been a concern in relation to metal components, particularly in hip replacements. We look at a possible correlation between hip joint effusion and metal ion levels.

Materials and methods

56 patients,(42M, 14F) agreed to the study. All had metal-on-mental arthroplasties. Average age was 64.2 (SD 9.8). All patients were asymptomatic.

Ultrasound examination performed by one ultrasonographer, using a Sonosite M-Turbo machine with a C60X/5-2 MHz transducer.

Cobalt levels were assessed using an inductively coupled plasma mass spectrometer. Chromium levels were assessed using a graphite furnace atomic absorption spectrometer.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 120 - 120
1 Jan 2016
Kohan L Farah S Field C Nguyen D Kerr D
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There has recently been an increase in the number of hip replacement procedures performed through an anterior approach. Every procedure has a risk profile, and in the case of a new procedure or technique it is important to investigate the incidence of complications. The aim of this study is to identify the complications encountered in the first 100 patients treated with the minimally invasive anterior approach.

This is a case series of the first 100 hips treated and were assessed for complications. These were classified according to the severity and outcome [1]. The 100 hip comprised of 98 patients; 46 males and 52 females with an average operation age on 70.1 (±9.38) years. There were 2 bilateral procedures. Specific patient selection criteria were used. All complications occurred within one month of surgery. Complications such as fracture, deep vein thrombosis (DVT), cup malposition, femoral stem malposition, retained screw, excessive acetabular reaming and skin numbness were noted. Complications associated with fracture were characterized as either periprosthetic or trochanteric. Clinical outcome scores of SF36v2, WOMAC, Harris Hip and Tegner activity score were analysed at pre-operative, 6 months, 12 months 24 months and 36 months intervals.

A total of 13 early complications occurred. Of these 13 complications the most common complications were trochanteric fracture, 3 instances (3.00%), periprosthetic fracture, 2 (2.00%), DVT, 2 (2.00%), numbness, 2 (2.00%) and loosening. Other complications recorded were cup malposition, 1 (1.00%), femoral stem malpositon, 1 (1.00%), retained screw, 1 (1.00%) and excessive acetabular reaming, 1 (1.00%). All fractures occurred in patients over the age of 60 years.

Significant differences (p<0.05) were observed between all clinical outcomes measures pre-operatively and postoperatively (6, 12, 24 and 36 months). The unfamiliarity of the approach, however, increased operating time, and exposure problems, lead to trochanteric fracture.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_2 | Pages 119 - 119
1 Jan 2016
Kohan L Farah S Field C Kerr D Nguyen D
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Introduction

Dissatisfaction with the posterior approach to total hip replacement has led to the anterior approach being adopted with enthusiasm in some areas.

Objectives

We aim to assess any difference between the 2 approaches and if so, the magnitude of this difference.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_3 | Pages 90 - 90
1 Jan 2016
Nizam I Kohan L Kerr D Field C
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Introduction

The observation of elevated heavy metal ions in arthroplasty patients in association with complications has led to concern on the part of patients and surgeons. The aim of this study was to determine the levels of cobalt chromium ions in three compartments, the joint fluid, plasma, and CSF.

Method

Patients were divided into 3 groups:

239 without any implant(M132F108)

50 having a supplementary implant, with a well performing contralateral THR.

– 16 large head MoM arthroplasty (Birmingham modular M7F9)

– 44 a Birmingham resurfacing(M39F5)

6 revisions of MoM bearings(M3F3)

Blood and CSF specimens were harvested at the time of induction of anaesthesia. Joint fluid was aspirated before the surgical incision was made under sterile conditions. Cobalt was assayed using an Agilent7500ce inductively coupled plasma mass spectrometer. Chromium was assayed with a graphite furnace atomic absorption spectrometer (Varian240zlGFAAS). Bivariate correlations were used to determine similarities between group


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 100 - 100
1 Mar 2013
Kohan L Field C Kerr D
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Comparisons of blood metal ion levels of cobalt and chromium (CoCr) between metal-on-metal total and resurfacing hip arthroplasties are limited. High levels of CoCr may result in long-term adverse biological effects. We compare metal ions levels between total and resurfacing implants.

70 patients (28 males and 42 females) had a total hip arthroplasty using the Birmingham (Smith & Nephew) modular femoral component and a variety of stems, articulating with the Birmingham resurfacing component. The average age was 65.5 (±6.8) years and an average follow-up of 6.0 (±2.2) years. 170 patients (145 male and 25 female had a Birmingham resurfacing arthroplasty with an average age of 54.7 (±9.9) years and an average follow-up of 5.9 (±3.0) years. CoCr levels were measured. Bivariate correlations and independent samples t-tests were applied to determine similarities and differences within and between groups.

Average ion levels in total arthroplasty patients were: Co 114.17 (±94.01) nmol/L (range 2–414); and Cr 75.12 (±68.45) nmol/L (range 10–312). Average levels in hip resurfacing arthroplasty were: Co 55.98 (±79.5) nmol/L (range 7–505); and Cr 70.77 (±87.41) nmol/L (range 5–751). Both total and resurfacing groups showed significant correlations (p<0.01) between Co and Cr levels. A significant difference was observed between the total and resurfacing group Co levels (p<0.0001). No significant difference was shown between group Cr levels (p>0.672).

The average total hip replacement CoCr levels were higher than the hip resurfacing levels. While the overall activity level may be higher in the resurfacing group, possibly the incidence of stop/start frequency may be higher in the total hip replacement group.

Hip resurfacing arthroplasty average CoCr levels are lower than those of total hip replacement patients. Associations between Co and Cr metal ion levels are shown within each group. Co levels differ significantly between groups where Cr does not. Long-term follow-up of CoCr levels are required.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 228 - 228
1 Mar 2013
Kohan L Field C Kerr D
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The Repicci modification of the Marmor unicompartmental arthroplasty (UKA) has provided a minimally invasive alternative to proximal tibial osteotomy for localised osteoarthritis. Advantages of UKA include preservation of bone, faster rehabilitation and maintained function. This study analyses the survivorship of the Repicci medial compartment arthroplasty with a minimum 10-year follow-up.

438 medial UKR procedures were performed between 01/01/1998 and 01/07/2001 included 68 bilateral procedures in 370 patients. The patients comprised of 229 males and 141 females. A specific set of selection criteria were used, including clinical, radiological, an arthroscopic data. The average age at operation was 66.7 years. The average follow-up was 12.8 years. For the patients who are not reachable, we sought the help of the Australian joint replacement registry. All revisions were identified. Procedures were reviewed to determine survivorship and function. Clinical outcomes scores of SF36v2. WOMAC and Oxford Knee were analysed at pre-operative, 1, 3, 5 and 10 year intervals.

In 54 patients (64 procedures) the implant was in situ at the time of death. Revision was carried out in 37 knees (8.5%) at a mean time period of 7.8 years (1–13) post-operatively. Of the revisions, the commonest cause was progression of arthritic changes in the lateral compartment, 25 patients. Loosening of the tibial component was present in six patients and for six patients whose data was obtained from the registry, revision was documented, but no cause was identified. Kaplan-Meier investigation showed survivorship of 91.6% to 12.5 years. Average pre-operative, 1, 3, 5 and 10 years SF36v2 Total scores were 107.80, 124.57, 124.83, 111.14 and 121.47. WOMAC Total scores for pre-operative, 1, 3, 5 and 10 years were 51.96, 83.34, 80.59, 82.00 and 78.54. Oxford Knee scores for pre-operative, 1, 3, 5 and 10 years were 35.76, 20.99, 19.28, 19.61 and 21.16.

Significant differences (p<0.0001) were observed between all pre-operative and post-operative 1, 3, 5 and 10 year outcomes of SF36v2, WOMAC and Oxford Knee scores.

UKR is an operation which is often regarded as a temporising procedure, on the way to a total knee replacement, the attrition rate is less than 1% per year, indicates that long-term function is a goal which may be achievable.

UKR provides satisfactory function, with a low revision rate, and a minimally invasive approach does not decrease the efficacy, while currently, improving function, speed of recovery, and patient satisfaction. Patient selection, particularly in relation to the status of the lateral compartment articular surface may be an important aspect in minimising revision incidence.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 101 - 101
1 Mar 2013
Kohan L Field C Kerr D
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The Birmingham mid-head hip resurfacing arthroplasty (Smith & Nephew, Tennessee) (BMHR) is designed for use in patients with avascular necrosis of the femoral head. The BMHR has limited short-mid term follow-up results. We report the experience of 27 consecutive BMHR procedures with a minimum two year follow-up.

23 patients (20 males and 3 females) with an average operation age of 49.8 years (SD ±10.9) (22–65) were investigated. The mean follow-up period was 3.0 years (SD ±0.77). The operations were between April 2008 and November 2011 by one surgeon. Data and outcome measurements were collected prospectively and analysed retrospectively. Procedures were reviewed to determine function. We evaluated Harris Hip Scores, Short Form-36 (SF-36v2) Scores, Tegner Activity Score Scores and McMaster Universities Osteoarthritis Index Scores (WOMAC) comparatively at preoperative, six month and yearly intervals. Paired samples t-tests were applied to determine improvements where p<0.05 was deemed as significant.

There were no patient deaths. There were no revisions. Harris Hip scores for pre-operative 6, 12, 24 and 36 month intervals were: 52.30, 84.14, 83.07, 87.50 and 89.50. Average pre-operative 6, 12, 24 and 36 month SF36v2 Total scores were: 116.54, 124.32, 130.44, 135.97 and 133.18. Tegner scores for pre-operative 2.75, 3.29, 3.00, 3.67 and 3.01. WOMAC Total scores for aforementioned intervals for the posterior approach were: 59.51, 84.22, 90.30, 86.86 and 92.25.

The mean Harris Hip scores improved significantly between preoperative and 6, 12, 24 and 36 months (p<0.001). The mean SF-36v2 physical scores improved significantly between preoperative and 6, 12, 24 and 36 months (p<0.016). WOMAC scores improved significantly between preoperative and 6, 12, 24 and 36 months (p<0.017).

The presence of avascular necrosis significantly increases the revision rate for hip resurfacing surgery. The BMHR prosthesis, in this short term follow-up, appears to avoid the main cause of failure, femoral component loosening. Longer term efficacy remains to be seen. We plan to continue close supervision of these patients.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 102 - 102
1 Mar 2013
Kohan L Field C Kerr D
Full Access

The Birmingham Hip Resurfacing (BHR) has been used in the younger more active patient for the treatment of advanced osteoarthritis. Long-term follow-up of the BHR is limited. The Australian national joint replacement registry shows that failure rates vary greatly, depending on implant types. 77 consecutive BHR procedures with a minimum ten year follow-up are reported.

There were 70 patients (44 males and 26 females) with an average operation age of 57.4 years (SD ±12.6). All patients were evaluated, including the “learning curve” patients. The mean follow-up period was 11.42 years (SD ±0.50). The arthroplasties were performed between April 1999 and December 2000 by one surgeon, with a standardised patient selection set of criteria. Data and outcome measurements were collected prospectively and analysed retrospectively. We evaluated Harris Hip Scores, Short Form-36 (SF-36v2) Scores, Tegner Activity Score Scores and McMaster Universities Osteoarthritis Index Scores (WOMAC) comparatively at preoperative, six month and yearly intervals

In 8 patients (10 procedures) the implant was in situ at the time of death. Revision was carried out in 6 hips (7.8%) at a mean time period of 2.5 years (0–10) post-operatively. Failure was due to femoral neck fracture in four patients, acetabular loosening in one and avascular necrosis of the femoral head, leading to loosening, in one patient. Kaplan-Meier analysis showed survivorship of 92.2% to 10 years. The mean Harris Hip scores (paired t-test, p<0.05) improved significantly from 59.7 preoperatively to 80.1 at ten years. The mean SF-36v2 physical scores (paired t-test, p<0.05) improved significantly from 35.09 preoperatively to 47.83 at ten years. WOMAC scores (paired t-test, p<0.05) improved significantly from 54.61 preoperatively to 85.89 at ten years.

The BHR prosthesis, in this series, has been shown to be effective, reliable, and durable in this group of highly active, relatively young patients. Problems with metallic debris, sensitivity reactions, and osteolysis have not been seen. However, we believe that with better selection criteria, improved understanding of component positioning and surgical techniques, results can be improved.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_15 | Pages 103 - 103
1 Mar 2013
Kohan L Field C Kerr D
Full Access

There is a report that higher failure rate in uncemented total knee replacement components due to loosening. However, uncemented fixation has been an attractive concept because of bone preservation and revision surgery, potential improved load transfer, and decreased surgical time. “Regenerex” is a porous titanium layer with excellent initial fixation, and the promise of providing favourable biological fixation. This is used with the Biomet Vanguard total knee replacement.

14 patients had undergone total knee replacement surgery comprising 11 men and three women with an average age of 63.07 years, and a body mass index of 30.33. Three of these patients required revision, because of tibial component loosening within 12 months of surgery. There were two men and one woman with an average age of 63.33 and BMI of 34.55. Clinically, patients developed pain and a gradual deformity as a result of a symmetrical collapse of the proximal tibial bony support surface.

Histopathology on the removed specimens shows the development of fibre cartilaginous metaplasia with evidence of necrotic bone. This was similar in all patients. There was no foreign body giant cell reaction, and no evidence of infection. The appearance was suggested of osteonecrosis, occurring gradually.

The incidence of frequency of this complication with this component in our experience is of concern, and the aim of this presentation is to determine whether this is a more widespread phenomenon.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLI | Pages 85 - 85
1 Sep 2012
Kohan L Field C Kerr D
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There has recently been an increase in the number of hip replacement procedures performed through an anterior approach. Every procedure has a risk profile, and in the case of a new procedure or technique it is important to investigate the incidence of complications. The aim of this study is to identify the complications encountered in the first 100 patients treated with the minimally invasive anterior approach.

This is a case series of the first 100 hips treated and were assessed for complications. These were classified according to the severity and outcome [1]. The 100 hip comprised of 98 patients; 46 males and 52 females with an average operation age on 70.1 (±9.38) years. There were 2 bilateral procedures. Specific patient selection criteria were used. All complications occurred within one month of surgery. Complications such as fracture, deep vein thrombosis (DVT), cup malposition, femoral stem malposition, retained screw, excessive acetabular reaming and skin numbness were noted. Complications associated with fracture were characterised as either periprosthetic or trochanteric. Clinical outcome scores of SF36v2, WOMAC, Harris Hip and Tegner activity score were analysed at pre-operative, 6 months, 12 months 24 months and 36 months intervals.

A total of 13 early complications occurred. Of these 13 complications the most common complications were trochanteric fracture, 3 instances (3.00%), periprosthetic fracture, 2 (2.00%), DVT, 2 (2.00%), numbness, 2 (2.00%) and loosening. Other complications recorded were cup malposition, 1 (1.00%), femoral stem malpositon, 1 (1.00%), retained screw, 1 (1.00%) and excessive acetabular reaming, 1 (1.00%). All fractures occurred in patients over the age of 60 years. There were no dislocations.

Significant differences (p<0.05) were observed between all clinical outcomes measures pre-operatively and postoperatively (6, 12, 24 and 36 months). The unfamiliarity of the approach, however, increased operating time, and exposure problems, lead to trochanteric fracture.


The Journal of Bone & Joint Surgery British Volume
Vol. 61-B, Issue 1 | Pages 96 - 100
1 Feb 1979
Hughes S Field C Kennedy M Dash C