The purpose of this study was to evaluate the
expression of acid-sensing ion channels (ASICs) in the capsule and synovial
fluid of patients with frozen shoulder. Capsular tissue and synovial
fluid were obtained from 18 patients with idiopathic frozen shoulder
(FS group) and 18 patients with instability of the shoulder (control
group). The expressions of ASIC1, ASIC2, and ASIC3 in the capsule
were determined using the reverse transcriptase-polymerase chain
reaction, immunoblot analysis, and immunohistochemistry (IHC). The
concentrations in synovial fluid were evaluated using an enzyme-linked
immunosorbent assay. The mRNA expression of ASIC1, ASIC2 and ASIC3 in the capsule
were significantly increased in the FS group compared with the control
group. The protein levels of these three ASICs were also increased.
The increased expressions were confirmed by IHC. Of the ASICs, ASIC3
showed the greatest increase in both mRNA and levels of expression
compared with the control group. The levels of ASIC1 and ASIC3 in
synovial fluid were significantly increased in the FS group. This study suggests that ASICs may play a role as mediators of
inflammatory pain and be involved in the pathogenesis of frozen
shoulder. Cite this article:
To assess the clinical comparison of closed suction drainage group and non drainage group after simultaneous total knee atrhroplasty. We analyzed the thigh circumference, ecchymosis, wound infection, transfusion amount, knee score and range of motion in 140cases (70patients) done with PFC or PFC-sigma model between 1998 and 2005. 100 cases of them(group )were inserted hemovac and the others (group )were not inserted hemovac. The average thigh circumference in group was 43.8cm (preoperative), and 47.3cm(postoperative), in group was 43.2cm (preoperative) and 47.9cm (postoperative). The knees that had no drains had a higher incidence of ecchymosis. However, the final result of knee score and range of motion of knee joint were not affected significantly by nonuse of closed suction drainage. There were no infection sign in both groups. The clinical comparison of closed suction drainage group and non drainage group after simultaneous bilateral total knee arthroplasty was not significantly different in wound healing, clinical and rehabilitation course. The use of suction drainage must be carefully selected after primary total knee arthroplasty.
