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Bone & Joint Open
Vol. 3, Issue 9 | Pages 716 - 725
15 Sep 2022
Boulton C Harrison C Wilton T Armstrong R Young E Pegg D Wilkinson JM

Data of high quality are critical for the meaningful interpretation of registry information. The National Joint Registry (NJR) was established in 2002 as the result of an unexpectedly high failure rate of a cemented total hip arthroplasty. The NJR began data collection in 2003. In this study we report on the outcomes following the establishment of a formal data quality (DQ) audit process within the NJR, within which each patient episode entry is validated against the hospital unit’s Patient Administration System and vice-versa. This process enables bidirectional validation of every NJR entry and retrospective correction of any errors in the dataset. In 2014/15 baseline average compliance was 92.6% and this increased year-on-year with repeated audit cycles to 96.0% in 2018/19, with 76.4% of units achieving > 95% compliance. Following the closure of the audit cycle, an overall compliance rate of 97.9% was achieved for the 2018/19 period. An automated system was initiated in 2018 to reduce administrative burden and to integrate the DQ process into standard workflows. Our processes and quality improvement results demonstrate that DQ may be implemented successfully at national level, while minimizing the burden on hospitals.

Cite this article: Bone Jt Open 2022;3(9):716–725.


Bone & Joint Research
Vol. 6, Issue 9 | Pages 550 - 556
1 Sep 2017
Tsang C Boulton C Burgon V Johansen A Wakeman R Cromwell DA

Objectives

The National Hip Fracture Database (NHFD) publishes hospital-level risk-adjusted mortality rates following hip fracture surgery in England, Wales and Northern Ireland. The performance of the risk model used by the NHFD was compared with the widely-used Nottingham Hip Fracture Score.

Methods

Data from 94 hospitals on patients aged 60 to 110 who had hip fracture surgery between May 2013 and July 2013 were analysed. Data were linked to the Office for National Statistics (ONS) death register to calculate the 30-day mortality rate. Risk of death was predicted for each patient using the NHFD and Nottingham models in a development dataset using logistic regression to define the models’ coefficients. This was followed by testing the performance of these refined models in a second validation dataset.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 30 - 30
1 Sep 2012
Al-Atassi T Chou D Boulton C Moran C
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Introduction

Cemented hemiarthroplasty for neck of femur fractures has been advocated over uncemented hemiarthroplasty due to better post-operative recovery and patient satisfaction. However, studies have shown adverse effects of bone cement on the cardio-respiratory system which may lead to higher morbidity and mortality. Therefore, in some institutes, the use of an uncemented prosthesis has been adopted for patients with a high number of co-morbidities. The aim was to compare early mortality rates for cemented vs. uncemented hemiarthroplasties.

Method

Cohort study of displaced intracapsular hip fractures treated with hemiarthroplasty between 1999–2009 at one institute. A total of 3094 hemiarthroplasties performed; out of which 1002(32.4%) were cemented and 2092(67.6%) were uncemented. 48hour and 30day mortality rates for the two groups were compared and a multivariate Cox regression model used to eliminate confounding factors. Significant confounding factor included age, sex, mini mental test score, medical co-morbidities, Nottingham Hip Fracture Score and delay to surgery.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 188 - 188
1 Jun 2012
Phillips J Boulton C Moran C Manktelow A
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We have identified 69 patients with Vancouver B1 periprosthetic fractures around stable femoral implants. Open reduction internal fixation is the recommended treatment; however recent studies have revealed high rates of nonunion. We have reviewed the fixation techniques utilized to treat these patients, and identified outcomes in relation to rates of union, further surgery and mortality.

Patients were identified from a prospective database of all trauma admissions at Nottingham University Hospitals from 1999 to 2010. Hospital notes were independently reviewed and data retrieved.

69 patients were identified. Mean age 77 years and 63% were female. 51 (74%) occurred around total hip replacements and 18 (26%) around hip hemiarthroplasty after a previous hip fracture.

Periprosthetic fracture occurred around an Exeter stem (n=18), Charnley (n=10), Austin Moore (n=15), other (n=6). 20 patients had undergone previous revision surgery. The mean time from index surgery to fracture was 58 months (median 24) around primary stems, and 48 months (median 22) around revision stems.

6 patients (9%) were treated non-operatively. Five of these had undisplaced fractures (all healed but one required revision due to loosening) and one was too unwell.

63 patients (91%) were treated by open reduction internal fixation. Of these, single plate fixation was performed in 40 cases (64%). In the vast majority of cases, lag screw fixation of the fracture with a long (>12 hole) pre-contoured 4.5mm locking plate was utilised with cables. Both locking and cortical screws were used to achieve stable fixation (Figure 1). A double plate technique was used in 16 cases (25%), where plates were placed perpendicularly to each other (laterally and anteriorly). Strut grafts were used in 13 cases (21%). 7 patients (11%) were treated with cables alone.

23 patients have subsequently died (33%). Two have been lost to follow up and three are awaiting union. There is a mean follow-up of 35 months.

Deep infection occurred in 4 cases (6%). Non-union occurred in four cases (6%). Two of these were infected and one was treated with cables alone. Malunion occurred in one case treated with cables. One patient had a dislocation and two superficial infections occurred.

Further surgery took place in 8 patients (12%). Three of the infected cases were revised and one underwent wound washout. The two other non-unions were revised. Three further revisions were performed: one for malunion, one for aseptic loosening (treated non-operatively) and another for a second periprosthetic fracture. Superficial wound washout was performed in one case.

Mortality was 10% at 3 months, 22% at 1 year and 47% at 3 years.

We have identified that union can be achieved in the majority of cases after periprosthetic fracture fixation. Cable fixation was associated with a high complication rate (7 cases: two requiring revision surgery: one nonunion, one malunion).

We recommend that Vancouver B1 periprosthetic fractures are treated with meticulous technique to achieve anatomical reduction and fracture compression using lag screw technique and plating. Further mechanical support can be provided through the use of a second plate, cables and/or strut grafts.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 187 - 187
1 Jun 2012
Phillips J Boulton C Moran C Manktelow A
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The clinical results of the cemented Exeter stem in primary hip surgery have been excellent. The Exeter ‘philosophy’ has also been extended into the treatment of displaced intracapsular hip fractures with ‘cemented bipolars’ and the Exeter Trauma Stem (Howmedica).

We have identified an increase in the number of periprosthetic fractures that we see around the Exeter stem. We have also identified a particular group of patients with comminuted fractures around ‘well fixed’ Exeter stems after primary hip surgery that present a particular difficult clinical problem.

Prior to fracture, the stems are not loose, the cement mantle remains sound and bone quality surrounding the reconstruction is good, i.e. classifying it as a Vancouver B1. However the comminuted nature of the fracture makes reduction and fixation with traditional methods difficult. Therefore in these particular circumstances it is often better to manage these as B2 or even B3 fractures, with distal bypass and uncemented reconstruction.

Over an eleven-year period since 1999, 185 patients have been admitted to Nottingham University Hospitals with a periprosthetic femoral fracture around a hip replacement. These patients were identified from a prospective database of all trauma patients admitted to the institution. Of these patients we have identified a cohort of 21 patients (11%) with a periprosthetic fracture around an Exeter polished stem. Hospital notes were independently reviewed and data retrieved. Outcome data was collected with end points of fracture union, re-revision surgery and death. Data was also collected on immediate and long term post-operative complications.

The mean age was 76 years at time of fracture, and 52% were male. The mean duration between primary index surgery and fracture was 18 months (median 11 months).

15 patients were classified as Vancouver B1, and six as B2 fractures. Of the B1 fractures, 14 underwent fixation and one was treated non-operatively. Of the B2 fractures, four were revised, one was revised and fixed using a plate, and one was fixed using a double-plating technique. Prior to fracture, none of the implants were deemed loose although one patient was under review of a stress fracture which subsequently displaced.

One patient died prior to fracture union. All the other patients subsequently went onto unite at a mean of 4 months. There were no deep infections, non- or malunions. No patient underwent further surgery. Dislocation occurred in one patient and a superficial wound infection occurred in one patient which responded to antibiotic treatment. Three other patients have subsequently died at seven, twelve and fifty-three months post fracture due to unrelated causes.

In our series of patients, in addition to the more standard fracture patterns, we have identified a very much more comminuted fracture. Indeed, we have described the appearance as if the tapered stem behaves like an axe, splitting the proximal femur as a consequence of a direct axial load. As a consequence of the injury, the cement mantle itself is severely disrupted. There is significant comminution and soft tissue stripping, calling into question the viability of the residual fragments. Treatment of this type of fracture using a combination of plates, screws and cables is unlikely to provide a sufficiently sound reconstruction. In our experience we believe these fractures around previously ‘well fixed’ Exeter stems should be treated as B2/B3 injuries.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 141 - 141
1 Mar 2012
Farmer J Aladin A Earnshaw S Boulton C Moran C
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Developments in plate technology have increased interest in the operative fixation of Colles' fracture. The vast majority of patients are treated non-operatively, yet there are few medium or long-term outcome studies.

The aim of this study was to evaluate medium-term outcome of a cohort of patients who previously received treatment in a plaster cast. 236 patients entered two previous prospective, randomised control studies comparing closed reduction techniques or plaster cast type. Both studies showed no difference in clinical or radiological outcome between groups. 43% of this cohort had a final dorsal tilt of > 10° and 44% had final radial shortening of >2mm. All patients now have a minimum follow-up of five years and 60 have died. The remaining 176 patients were contacted by post and asked to complete two validated patient-based questionnaires: a modified Patient Evaluation Measure and a quickDASH. 112 replies were received. The mean age of patients is 67 years (range 23 – 91 years). 31 patients are employed and 57 retired. 77% of patients had a quickDASH score of less than 20. 59% of patients never experience wrist pain whilst 8% of patients have daily pain.

All Patient Evaluation Measures have shown a median score of 12 or less (0=excellent, 100= terrible). The best score was for pain (median 4; IQR 2-12) and the worst for grip strength (median 12; IQR 4 – 41). No radiological outcome 5 weeks after injury correlated with any outcome score, except for dorsal tilt, which correlated with difficulty with fiddly tasks (p=0.04) and carpal malalignment which correlated with interference with work (p=0.04).

In conclusion, our results show a good functional outcome five years after non-operative management of Colles' fracture. A degree of malunion is acceptable and in the light of our results the economic impact of surgery must be evaluated.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 96 - 96
1 Mar 2012
Edwards C Boulton C Counsell A Moran C
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The aim of this study was to investigate the risk factors, financial costs and outcomes associated with infection after hip fracture surgery.

Prospective hip fracture data from the University Hospital, Nottingham, was analysed, assessing patients with either deep or superficial wound infections admitted over a five year period.

3605 patients underwent hip fracture surgery. 2.3% of these patients developed a wound infection of which 1.2% were deep wound infections. 75% of infections were due to Staphylococcus aureus and 50% of all infections were caused by methicillin-resistant Staphylococcus aureus.

No statistically significant risk factors for the development of infection were identified in this study.

Length of stay, cost of treatment and pre-discharge mortality were all increased with deep infection. Deep wound infection increased the average length of stay from 28 days to 100 days. This quadrupled the ward costs. The mean overall hospital cost of treating a hip fracture complicated by deep wound infection was £34903 compared to £8979 fro those who did not develop infection. Pre-discharge mortality increased from 24.2% in the control group to 30% in the infected group (p<0.006).

MRSA significantly increased costs, LOS, and pre-discharge mortality compared with non-MRSA infection.

These results show the huge impact that infection after hip fracture surgery has both on mortality and hospital costs.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 97 - 97
1 Mar 2012
Chantrey J Blanckley S Boulton C Moran C
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The aim of the study was to assess the mortality associated with a hip fracture at 5 years in a geriatric population, and to evaluate the influence of age, cognitive state, mobility and residential status on long term survival after hip fracture.

This study forms part of a prospective audit of all patients with a hip fracture admitted to Queen's Medical Centre, Nottingham. Every patient has a detailed admission questionnaire completed including details of the injury, medical history, residence and mobility. All data is collected by independent audit personnel using a detailed proforma. Integration with the database of the Office for National Statistics ensured accurate mortality data for every patient in the study for at least 5 years. All patients admitted in a 2 year period were included and divided into two groups: group B (<80 yrs age, Abbreviated Mental Test score 7/10, admitted from own home, independently mobile) and group A (any patient who did not fulfil all of group B criteria). A multivariate analysis indicated these as important variables that predicted mortality. Exclusion criteria: pathological hip fracture or bilateral hip fractures.

1319 patients fitted the inclusion criteria. 1068 patients fulfilled criteria for group A, 251 patients for group B. Overall mortality was 71% at 5 years. The excess mortality for the first year was 43%. 151 patients (60%) of group B were still alive at 5 years in comparison with only 231 (22%) of group A. Increased survival was shown for each variable: independent mobility RR 2.34 (p<0.05), admitted from home RR 3.81 (p<0.05), age<80 years RR 3.95 (p<0.05) and AMT 7/10 RR 5.45 (p<0.05).

These results facilitate early recognition of those patients with an increased chance of long-term survival that may be suitable for surgical treatment, such as total hip replacement, which have a good long-term outcome.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 314 - 314
1 Jul 2011
Karantana A Boulton C Shu KSS Moran C
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Methods: We examined prospectively collected data from 6782 consecutive hip fractures to identify 327 fractures in female patients aged 65 years and younger. We report on demographic characteristics, treatment and outcome. We compare this group with a cohort of 4810 consecutive hip fractures in older females.

Results: Not surprisingly, younger women had higher levels of mobility and independence than their older counterparts. However, over 20% mobilised with aids, needed help with activities of daily living and/or had significant co-morbidity. A significantly higher proportion of younger patients were smokers. This had a strong influence on the relative risk of “early” as opposed to “late” fracture (Hazard Ratio 4.7, p< 0.01). Mortality was 0.7% at 30 days and 4.2% at one year.

We calculated age-related incidence of hip fracture in the local population and noted the first significant increase at the interval between 40–44 and 45–49, rather than the age of 50, which is when the onset of screening of hip fracture patients for osteoporosis occurs in most health areas. Lag screw fixation was the most common method of operative fixation. General complication rates were low, as were reoperation rates for cemented prostheses. Intracapsular fractures are an interesting subgroup. When displaced, 39% (61/158) had lag screw fixation and 61% (97/158) were treated by arthroplasty. Kaplan-Meier implant survivorship of displaced intra-capsular fractures treated by reduction and lag screw fixation was 82% at two and 71% at five years.

Conclusion: Hip fractures in females to 65 years of age are sustained by a population at risk as a result of patho-physiology. Treatment in this age group, particularly of intracapsular fractures, remains a topic of debate. Understanding the characteristics of these patients, may lead to an improved opportunity, if not for prevention, at least for intervention.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 6 | Pages 801 - 805
1 Jun 2011
Quah C Boulton C Moran C

This is the first study to use the English Indices of Multiple Deprivation 2007, the Government’s official measure of multiple deprivation, to analyse the effect of socioeconomic status on the incidence of fractures of the hip and their outcome and mortality. Our sample consisted of all patients admitted to hospital with a fracture of the hip (n = 7511) in Nottingham between 1999 and 2009.

The incidence was 1.3 times higher (p = 0.038) in the most deprived populations than in the least deprived; the most deprived suffered a fracture, on average, 1.1 years earlier (82.0 years versus 83.1 years, p < 0.001). The mortality rate proved to be significantly higher in the most deprived population (log-rank test, p = 0.033), who also had a higher number of comorbidities (p = 0.001).

This study has shown an increase in the incidence of fracture of the hip in the most deprived population, but no association between socioeconomic status and mortality at 30 days. Preventative programmes aimed at reducing the risk of hip fracture should be targeted towards the more deprived if they are to make a substantial impact.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 5 | Pages 658 - 664
1 May 2011
Karantana A Boulton C Bouliotis G Shu KSS Scammell BE Moran CG

We examined prospectively collected data from 6782 consecutive hip fractures and identified 327 fractures in 315 women aged ≤65 years. We report on their demographic characteristics, treatment and outcome and compare them with a cohort of 4810 hip fractures in 4542 women aged > 65 years.

The first significant increase in age-related incidence of hip fracture was at 45, rather than 50, which is when screening by the osteoporosis service starts in most health areas. Hip fractures in younger women are sustained by a population at risk as a result of underlying disease. Mortality of younger women with hip fracture was 46 times the background mortality of the female population. Smoking had a strong influence on the relative risk of ‘early’ (≤ 65 years of age) fracture.

Lag screw fixation was the most common method of operative treatment. General complication rates were low, as were re-operation rates for cemented prostheses. Kaplan-Meier implant survivorship of displaced intracapsular fractures treated by reduction and lag screw fixation was 71% (95% confidence interval 56 to 81) at five years. The best form of treatment remains controversial.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 137 - 137
1 May 2011
Chou D Taylor A Boulton C Moran C
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Aims: Reverse oblique intertrochanteric fractures (OTA/ AO 31-A3) have unique biomechanical properties that confer difficulties in obtaining stable fixation with the conventional sliding dynamic condylar screw. Recent studies have recommended the use of cephalocondylic intramedullary devices for these unstable fractures. Both the Proximal Femoral Nail (PFN) and the Gamma Nail (GN) have shown good outcome results but the results of treatment with the IMHS have not been reported in the literature.

Methods: Between 1999–2008 6724 consecutive hip fractures were treated at our institute. There were 2586 extracapsular fractures and 307 subtrochanteric fractures. 115 of the extracapsular fractures had a reverse oblique pattern and 63 of these were treated with the IMHS. We retrospectively reviewed clinical and radiological records for the reverse oblique intertrochanteric fractures treated with the IMHS. Follow-up duration ranged from 8 months to 6 years.

Results: Among the 63 patients treated with the IMHS, 56 (88%) fractures were reduced satisfactorily with only one poorly positioned hip screw in the femoral head. There were no cases of femoral shaft fracture, screw cut-out or collapse at the fracture site. The orthopaedic complications were two cases of mal-rotation, two cases of non-union, two cases of distal locking bolts backing out, and one cracked nail. 30 day mortality was 6.5%.

Conclusion: Cephalo-medullary nailing devices have been recommended for the treatment of reverse oblique intertrochanteric femoral fractures. Our clinical and radiological outcomes with the IMHS compare favourably to the results in reports where other cephalo-medullary devices have been used. Therefore we consider the IMHS a good option for the treatment of these unstable fractures.


The Journal of Bone & Joint Surgery British Volume
Vol. 93-B, Issue 3 | Pages 393 - 398
1 Mar 2011
Findlay JM Keogh MJ Boulton C Forward DP Moran CG

We performed a retrospective study of a departmental database to assess the efficacy of a new model of orthopaedic care on the outcome of patients with a fracture of the proximal femur. All 1578 patients admitted to a university teaching hospital with a fracture of the proximal femur between December 2007 and December 2009 were included. The allocation of Foundation doctors years 1 and 2 was restructured from individual teams covering several wards to pairs covering individual wards. No alterations were made in the numbers of doctors, their hours, out-of-hours cover, or any other aspect of standard patient care. Outcome measures comprised 30-day mortality and cause, complications and length of stay. Mortality was reduced from 11.7% to 7.6% (p = 0.007, Cox’s regression analysis); adjusted odds ratio was 1.559 (95% confidence interval 1.128 to 2.156). Reductions were seen in Clostridium difficile colitis (p = 0.017), deep wound infection (p = 0.043) and gastrointestinal haemorrhage (p = 0.033). There were no differences in any patient risk factors (except the prevalence of chronic obstructive pulmonary disease), cause of death and length of stay before and after intervention. The underlying mechanisms are unclear, but may include improved efficiency and medical contact time.

These findings may have implications for all specialties caring for patients on several wards, and we believe they justify a prospective trial to further assess this effect.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 6 | Pages 770 - 777
1 Jun 2008
Edwards C Counsell A Boulton C Moran CG

Prospective data on hip fracture from 3686 patients at a United Kingdom teaching hospital were analysed to investigate the risk factors, financial costs and outcomes associated with deep or superficial wound infections after hip fracture surgery.

In 1.2% (41) of patients a deep wound infection developed, and 1.1% (39) had a superficial wound infection. A total of 57 of 80 infections (71.3%) were due to Staphylococcus aureus and 39 (48.8%) were due to MRSA.

No statistically significant pre-operative risk factors were detected. Length of stay, cost of treatment and pre-discharge mortality all significantly increased with deep wound infection. The one-year mortality was 30%, and this increased to 50% in those who developed an infection (p < 0.001). A deep infection resulted in doubled operative costs, tripled investigation costs and quadrupled ward costs.

MRSA infection increased costs, length of stay, and pre-discharge mortality compared with non-MRSA infection.