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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_III | Pages 70 - 70
1 Feb 2012
Watts A Teoh K Beggs I Porter D
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This study investigates the experience of one treatment centre with routine surveillance MRI following excision of sarcoma. Casenotes, MRI and histology reports for fifty-nine patients were reviewed. The primary outcome was the presence of local tumour recurrence and whether this was identified on surveillance or interval scanning. Forty-eight patients had a diagnosis of soft tissue sarcoma, the remaining 11 a primary bone tumour. Fifteen patients had local recurrence (25%). Eight were identified on surveillance scan, and the remaining 7 required interval scans.

Surveillance scanning has a role in the early detection of local recurrence of bone and soft tissue sarcoma.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 379 - 380
1 Jul 2010
Cowie J Beggs I Gibson J
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Background: Several recent studies have compared incorporation of autograft with that of allograft or synthetic bone substitutes in anterior cervical discectomy and fusion (ACDF). These studies have almost universally relied on plain radiography to assess bone incorporation despite the fact that we know, from similar lumbar spine studies, that bone ingrowth is over-estimated.

Our aim was to determine the exactly whether bone incorporation may be correctly assessed by this method by comparing the results to those obtained by spiral CT imaging.

Methods: 15 patients underwent ACDF. Helical CT scans were obtained. Fusion was defined as trabecular continuity across the disc space anterior, through and posterior to the cage proximally and distally and assessed by two of the authors independently.

Results: 14 of the 15 patients appeared to have solid incorporation of bone graft/substitute on plain radiography, 19 out of 20 cages. These findings were not however replicated on CT imaging. The autograft was not considered to have been incorporated proximally above the cage in 5 cases and distally in 6 cases.

Discussion: The implication of our results is that there is at least a false positive rate of bone incorporation of 20–25%. Pseudarthroses are generally painful and therefore we would recommend that spiral CT imaging is performed in patients who have ongoing pain following ACDF.

Ethics approval: COREC Ethics committee number 06/S1104/34

Interest Statement: None of the authors have received any grants to carry out this research.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 397 - 398
1 Jul 2008
Watts A Teoh K Evans T Beggs I Porter D
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Introduction: Local recurrence of tumour following definitive treatment of bone or soft tissue sarcoma is a predictor of increased morbidity. Early detection of local recurrence may affect outcome. The role of magnetic resonance imaging (MRI) screening following definitive treatment is controversial. This study investigates the experience of one treatment centre with routine surveillance MRI following treatment of sarcoma.

Methods: Patients were identified from the records of the Regional Sarcoma Group. With Local Ethics Committee approval the casenotes, MRI and histology reports for sixty-five patients who had routine surveillance MRI scans following definitive treatment of sarcoma in a single treatment centre were reviewed. The minimum follow up period was 24 months. The primary outcome was the presence of local tumour recurrence and whether this was identified on surveillance or interval scanning.

Results: There were sixty-four patients identified with a bone or soft tissue sarcoma. All had undergone surveillance scanning biannually for the first year then annually. Six patients with Ewing’s sarcoma were excluded because they had not had surgical excision. Fifty-eight patients (59% men) with a bone or soft tissue sarcoma without metastasis between 1996 and 2003 were available for study. The median age at diagnosis was 53 years (range 6–78 years). Eighty three percent had a diagnosis of soft tissue sarcoma. Ten patients had a primary bone tumour. Fourteen patients had local recurrence (24%). Six were identified on surveillance scan, and the remaining eight required interval scans because of clinical suspicion of tumour recurrence. There were no statistical differences in gender, age, or tumour characteristics between those identified on surveillance or interval scans. All those detected on surveillance had intra-lesional or marginal resections.

Conclusions: Surveillance scanning has a role in the early detection of local recurrence of bone and soft tissue sarcoma. Whether this results improvements in prognosis require longer-term follow up studies.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 6 | Pages 685 - 696
1 Jun 2008
Robinson CM Jenkins PJ Markham PE Beggs I

The sternoclavicular joint is vulnerable to the same disease processes as other synovial joints, the most common of which are instability from injury, osteoarthritis, infection and rheumatoid disease. Patients may also present with other conditions, which are unique to the joint, or are manifestations of a systemic disease process. The surgeon should be aware of these possibilities when assessing a patient with a painful, swollen sternoclavicular joint.


The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 4 | Pages 484 - 487
1 Apr 2008
Watts AC Teoh K Evans T Beggs I Robb J Porter D

This study reports the experience of one treatment centre with routine surveillance MRI following excision of musculoskeletal sarcoma. The case notes, MRI and histology reports for 57 patients were reviewed. The primary outcome was local tumour recurrence detected on either surveillance MRI in asymptomatic patients, or interval MRI in patients with clinical concern. A total of 47 patients had a diagnosis of soft-tissue sarcoma and ten of a primary bone tumour. A total of 13 patients (22%) had local recurrence. Nine were identified on a surveillance scan, and four by interval scans. The cost of surveillance is estimated to be £4414 per recurrence detected if low-grade tumours with clear resection margins are excluded. Surveillance scanning has a role in the early detection of local recurrence of bone and soft-tissue sarcoma.


The Journal of Bone & Joint Surgery British Volume
Vol. 76-B, Issue 5 | Pages 688 - 689
1 Sep 1994
Johnstone A Beggs I


The Journal of Bone & Joint Surgery British Volume
Vol. 68-B, Issue 2 | Pages 305 - 310
1 Mar 1986
Dohler Souter W Beggs I Smith G

Hyperphosphatasia, or hereditary bone dysplasia with hyperphosphatasaemia, is a rare genetic disorder which is characterised by failure to transform woven into lamellar bone. Clinical, radiological and histological features establish the diagnosis, fractures, deformities, diffuse sclerosis on radiographs and high serum alkaline phosphatase being characteristic. We report the case of a 27-year-old man with follow-up at the same hospital for 20 years. Attempts at treatment with calcitonin and disocium etidronate (EHDP) failed, but stapling of the growth plates at the knee was successfully performed. Transverse "brittle" fractures of the humerus, lower leg and ribs healed normally, but internal fixation and late bone grafting were required for a subtrochanteric stress fracture of the femur at the age of 24 years. At present the patient has no clinical problems and leads a normal life.