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Bone & Joint Open
Vol. 3, Issue 11 | Pages 898 - 906
15 Nov 2022
Dakin H Rombach I Dritsaki M Gray A Ball C Lamb SE Nanchahal J

Aims

To estimate the potential cost-effectiveness of adalimumab compared with standard care alone for the treatment of early-stage Dupuytren’s disease (DD) and the value of further research from an NHS perspective.

Methods

We used data from the Repurposing anti-TNF for Dupuytren’s disease (RIDD) randomized controlled trial of intranodular adalimumab injections in patients with early-stage progressive DD. RIDD found that intranodular adalimumab injections reduced nodule hardness and size in patients with early-stage DD, indicating the potential to control disease progression. A within-trial cost-utility analysis compared four adalimumab injections with no further treatment against standard care alone, taking a 12-month time horizon and using prospective data on EuroQol five-dimension five-level questionnaire (EQ-5D-5L) and resource use from the RIDD trial. We also developed a patient-level simulation model similar to a Markov model to extrapolate trial outcomes over a lifetime using data from the RIDD trial and a literature review. This also evaluated repeated courses of adalimumab each time the nodule reactivated (every three years) in patients who initially responded.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_II | Pages 99 - 99
1 Feb 2012
Candal-Couto J Gamble G Astley T Rothwell A Ball C
Full Access

The aim of the New Zealand National Shoulder Arthroplasty Register is to evaluate the provision of shoulder arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all shoulder replacements performed in New Zealand.

An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete the Oxford Shoulder Score and comment on post-operative complications.

Data from 686 consecutive primary and 44 revision shoulder arthroplasties were prospectively collected from January 2000 until December 2003. 82 surgeons performed shoulder arthroplasty during the study period but only 9 performed on average more than 5 per year. Their results at 6 months were statistically superior to those provided by other surgeons. Amongst all diagnoses, osteoarthritis scored significantly better than the rest and for this condition total shoulder replacement scored higher than hemiarthroplasty. 15 different prostheses were used, many of them too infrequently. There was no difference in outcome amongst the 5 most commonly used prostheses. The number of complications reported by patients and the revision rate within the study period was low. No benefit was observed in the use of laminar flow theatre to prevent infection.

The combination of technical data about the joint implanted and the individual patient assessment has made the New Zealand Shoulder Arthroplasty Register unique in its own kind. Our findings are in general agreement with the current literature and supports the idea that shoulder arthroplasty is better provided by surgeons with a higher yearly case-load.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 222 - 222
1 Mar 2010
Caughey M Brick M Ball C Brown C Leigh W
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The aim of this study is to prepare for the introduction of the world’s first nationwide registry of all rotator cuff tears proceeding to operative management.

Patient’s are scored pre-operatively and again at six and 12 months post-op using the Flex SF functional scale, pain scales and work and activity levels. A questionnaire is filled out by the operating surgeon on the day of surgery detailing pathology and the operative methods used.

This study is a New Zealand Shoulder and Elbow Society initiative begun in 2007. New Zealand is ideally suited with a small, cohesive group of orthopaedic surgeons. Rotator cuff surgery is advancing rapidly with changes in surgical approach from open to arthroscopic, and repair methods from bone tunnels to various choices of anchors. A wide range of surgical methods are used within New Zealand, presenting an opportunity to use the large numbers generated by a registry to give valuable information guiding future treatment.

The operation day questionnaire includes information on tear size, surgical approach, repair methods, biceps and AC joint pathology and rehabilitation.

More than 100 patients have already been registered in the pilot study and a number have completed the six month questionnaire. These early results will be presented, along with important information for the large number of surgeons who will become involved when the nationwide registry commences.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 221 - 221
1 Mar 2010
Leigh W Ball C Brown C
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Dislocation of the elbow with associated fractures of the radial head and the coronoid process of the ulna have been referred to as the “terrible triad of the elbow” because of the difficulties in treating this injury and the poor outcomes.

The orthopaedic database, Orthoscope, was used to identify all patients with dislocation of the ulnohumeral joint and fracture of both the head of the radius and the coronoid process of the ulna, seen and treated at Auckland City Hospital since 1998.

All patients were invited to follow up appointments to evaluate the outcomes achieved. The research protocol was approved by the local research committee. Follow up appointments consisted of clinic al examination, assessing the range of elbow motion, an elbow radiograph and a functional assessment, using the DASH score and the American Shoulder and Elbow Society scoring systems.

There were 32 patients identified, from Orthoscope, and invited for follow up. Six patients, who had moved overseas, were lost to follow up and two others declined follow up. 23 patients (24 elbows) remained for evaluation. All patients returned for the described assessment protocol. There were 10 male patients and 13 female patients, with a mean age of 46.9 (range, 29 to 67 years). The average arc of ulnohumeral motion was 122 degrees (range; 110 degrees to 140 degrees) and that of forearm rotation was 138 degrees (range, 35 degrees to 170 degrees).

The radial head component was fixed in a standard fashion with repair, or replacement, and no radial head excisions were undertaken. Coronoid fractures were treated with screw fixation or suturing, with drill holes or anchors. To augment stability, a lateral ligament repair was undertaken in most patients. All patients, except one, would undergo the procedure again if needed.

Elbow fracture-dislocations are historically very unstable and are prone to numerous complications. With operative treatment of the radial head, with repair or replacement, to restore stability through radiocapitellar contact, coronoid and lateral ligament repair, good range of movement and stability can be achieved.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 340 - 340
1 May 2009
Everts N Astley T Ball C Poon P
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Reverse shoulder arthroplasty has been used to treat arthritis of the shoulder with no rotator cuff. The purpose of this study is to review the short term outcome of reverse shoulder arthroplasty performed at North Shore Hospital.

Between 2003 and 2007, 54 consecutive patients were treated with the SMR reverse shoulder prosthesis. Patients were assessed using the visual analogue pain score, patient satisfaction rating, the American Shoulder and Elbow Society Shoulder score, the Oxford shoulder score, the Short Form – 12, and by radiographs. We also reviewed clinical and radiographic complications.

Nine patients underwent surgery for fracture, two for chronic dislocation and 43 for cuff tear arthropathy, including four revisions. The mean age at surgery was 77.8 years (range 54–91 years). 53 of the implanted prostheses were SMR (Lima Orthotec) and one was a Delta (De Puy). Patient assessment is still in progress, but findings so far show very favourable early outcomes.

We report a large consecutive series of patients who had the reverse prothesis at North Shore hospital. To the best of our knowledge, there has been no previous publication of results of the SMR reverse prosthesis


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 341 - 341
1 May 2009
Pandit S Astley T Ball C Poon P
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Avulsion of the distal biceps tendon is an uncommon clinical entity accounting for 3% of all biceps tendon injuries. Various surgical techniques for its repair have been reported, however, the optimal technique is unknown. The two-incision technique is used by three upper limb surgeons at North Shore Hospital. There has been some concern regarding the risk of heterotopic bone formation with this technique. We present a review of a series of patients with distal biceps tendon ruptures treated with the modified two-incision technique to identify and describe any complications that we encountered and also assess the clinical, functional and radiological outcomes of our patients.

Over a 4-year period from 2002–2006, 42 distal biceps tendons repairs using the two-incision technique were identified from the hospital database. All 42 patients were males with an average age of 51.9 years. Patients were followed-up prospectively and reviewed at a clinic where they filled out the SF-12 questionnaire and a Mayo Elbow Performance Score was assessed. Clinical assessment was carried out with regards to their range of flexion-extension and their pronation-supination. All peripheral nerves were examined. Isokinetic elbow flexion-extension and forearm pronation-supination were measured and compared to the unaffected extremity. X-rays were taken to identify heterotrophic ossification or proximal radioulnar synostoses.

Our review, so far, indicates a good clinical and functional outcome in most of our patients. We identified one patient with heterotrophic bone formation requiring excision. Two patients had a transient lateral ante-brachial cutaneous nerve parasthesia and two patients had re-ruptures following surgery.

This study represents a relatively large series of patients. Our results reveal that the two-incision technique is an effective surgical option for the repair of ruptured distal biceps tendons. We found that radioulnar synostoses and heterotrophic ossification are rare following the muscle splitting modification of the two-incision technique.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 259 - 259
1 May 2009
Malone A Funk L Mohammed K Ball C
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We document intra-articular pathology in collision athletes with shoulder instability and describe the ‘collision shoulder’ – a direct impact without dislocation, with unusual labral injury, significant intra-articular pathology and neurology. 183 collision athletes were treated for labral injuries in 3 centres. Details of injury mechanism and intra-articular pathology at surgery were recorded. Premier league and International (Elite) comprised 72 players. A tackle was implicated in 52% of injuries and 65% had a dislocation. The mechanism of injury was ABduction External Rotation (ABER) in 45%, direct impact 36%, abduction only 8% and axial load 6%. Dislocation occurred in 51% of shoulders with ABER mechanism. A Bankart lesion was found in 79% of these shoulders; Hill-Sachs in 58% and Bony Bankart in 26%. Inferoposterior labral tears were present in only 11%, Superior Labral Antero-Posterior (SLAP) lesions in 32% and partial injury to the rotator cuff in 32%. In those sustaining a direct impact to the shoulder, 61% did not document dislocation, had a high incidence of inferoposterior labral involvement (50%), neurological symptoms (32%), but a low incidence of Bankart (33%), Hill-Sachs (22%) and Bony Bankart (11%) lesions. The mechanism did not affect incidence of superior labral/SLAP tears (18%), or capsular tears (including Humeral Avulsion of Glenohumeral Ligaments – HAGL) – 15%. Elite athletes had less dislocations (43% vs 74%) irrespective of mechanism, but were 40% more likely to have neurology, posteroinferior labral, cartilaginous or capsular injuries. They had twice the incidence of Bony Bankart and rotator cuff lesions and 5 times more SLAP/superior labral tears. Collision athletes with shoulder instability have a wide spectrum of pathoanatomy of the labrum and frequent associated intra-articular lesions. Significant injury often occurs in the Elite athlete and those sustaining a direct hit without dislocation (the ‘Collision Shoulder’).


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 341 - 341
1 May 2009
Ball C Mohammed K Funk L Malone A
Full Access

The spectrum of pathoanatomy in collision athletes with shoulder instability is wide, with a high incidence of extended labral lesions and associated intra-articular injuries. The ‘collision shoulder’ describes an injury sustained by direct impact to the shoulder without dislocation, but with extensive labral damage and a high incidence of other intra-articular pathology and neurological symptoms.

One hundred and eighty-three collision athletes (rugby and rugby league) were treated for labral injuries related to their sport in three different centres. Details of the mechanism of injury and findings at surgery were recorded. Only 60% of athletes in the series presented following a documented dislocation or subluxation episode of the shoulder. An additional pattern of injury was recognised in the remaining athletes involving a direct impact injury to the shoulder. In these athletes the clinical symptoms and signs were less specific but there was a high incidence of ‘dead arm’ at the time of injury (72%).

The spectrum of pathology in this series was wide with a high incidence of associated intra-articular lesions. In those athletes with an impact type of injury without dislocation there was more extensive labral pathology with a high incidence of posterior labral tears (50%). The incidence of associated chondral lesions was similarly very high but significant bony pathology was less common than in the dislocation group (11 % versus 26%). Elite athletes had less frank dislocations but were more likely to sustain neurological injury, posterior labral tears, SLAP lesions and cartilaginous and capsular injuries.

The incidence of all lesions in this series of collision athletes is higher than those previously published. These lesions often occurred in the absence of a frank dislocation (the ‘collision shoulder). It is important to anticipate additional pathology when planning definitive management in these patients, with surgery tailored to the specific lesions found. The athlete with an impact type of injury without dislocation can do well following surgery, with a high rate of return to contact sport, either at the same or a higher level.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 211 - 211
1 Jul 2008
Candal-Couto J Gamble G Astley T Rothwell A Ball C
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The aim of the New Zealand Elbow Arthroplasty Register is to evaluate the provision of elbow arthroplasty across the entire country by both recording accurate technical information and measuring the clinical outcomes of all elbow replacements performed in New Zealand. An initial form is completed at the time of surgery which includes details of the patient, surgical indications, the surgical procedure, the implant and the operating surgeon. Six months following surgery, all registered patients are asked to complete a questionnaire to measure the pain and function of the replaced elbow and to comment on any post operative complications. Data from 99 consecutive primary and 16 revision elbow arthroplasties was prospectively collected from January 2000 till December 2003. Rheumatoid arthritis was the commonest indication (63 cases) and the outcome was significantly better than for trauma and osteoarthritis. The Coonrad-Morrey was the most commonly used prosthesis (86 cases) followed by the Kudo (eight cases) and the Acclaim (five cases). 21 surgeons performed elbow arthroplasty during the study period but only five performed on average more than one case per year. Their results at six months were statistically superior to those provided by other surgeons. The number of complications reported by patients and the revision rate within the study period was low. An infection was seen in only two patients. The New Zealand Elbow Arthroplasty Register has become a robust method of assessment of the provision of elbow arthroplasty within the country. Our findings support the idea that elbow arthroplasty should not be performed by general orthopaedic surgeons on an occasional basis.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 332 - 332
1 Sep 2005
Ball C Hassan A
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Introduction and Aims: Isolated rupture of the subscapularis tendon is an uncommon condition that has generally been treated by early surgical repair. However, very little information is available regarding functional outcome following surgery. The purpose of this study was to evaluate patient reported outcome following surgical repair with a minimum follow-up of 12 months.

Method: Thirteen consecutive patients underwent arthroscopy followed by open surgical repair of an isolated traumatic rupture of the subscapularis tendon. A deltopectoral approach was used in all cases with repair of the tendon using suture anchors. Tenodesis of the long head of the biceps tendon was carried out in all patients because of instability or rupture. Standardised pre- and post-operative examinations were performed which included goniometric measurements of range of motion and an assessment of subscapularis function and strength. The ASES Shoulder Assessment Form was completed both pre-operatively and at final review.

Results: All patients reported significant pain and functional limitations pre-operatively, with an average pain score of 7/10 and ASES score of 41.2. Limitation of active arm elevation and clinical evidence of sub-scapularis rupture was present in all but one patient. At an average follow-up of 18 months all patients were satisfied and would undergo the procedure again. The average ASES score improved to 91.9, with all patients reporting minimal or no pain. All patients regained overhead elevation and external rotation to within 10 degrees of the other side. Internal rotation and subscapularis function improved in all patients. There were no complications.

Conclusion: Early surgical repair of isolated tears of the subscapularis tendon provides excellent pain relief and reliable restoration of shoulder function and strength. Patient satisfaction is high and the average ASES score can be significantly improved. Associated abnormalities of the long head of biceps tendon are common and should be addressed at the time of surgery.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 265 - 265
1 Mar 2004
Ridgeway S Steinlechner C Tai C Graevett-Ball C Carey-Smith R Harrison D
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Aims: To study the outcome of lumbar spinal fusions in patients with chronic lower back pain due to degenerative spinal disorders. Methods: 85 patients with DSD’s, a mean age of 46.4 years, back pain for at least 2 years (mean=7.7years) and failed conservative treatment for at least 1 year were admitted to the study. Questionnaires recorded socio-demographic characteristics; changes in pain, clinical findings, disability (Oswestry (ODI)), employment, radiographic fusion, patient satisfaction and complications. All patients had 3, 6, 12 and 24-month follow-ups. Results: There were 37 males (44.9years) and 48 females (47.6 years) with a mean BMI of 24.8; 49% were smokers. Pain improved significantly at 3months (p< 0.001); no deterioration at 2 years with 38.4% having no back pain. Motor (p< 0.01), sensory (p< 0.05) and Oswestry Disability (0.001) improved significantly at 3 months and continued throughout. Unemployment improved significantly 30.4% to 16.5% at 2 years (p< 0.04). Radiographic fusion occurred in 91.8%, instrument failure in 11.8% and 9.4% required re-operation. Patient satisfaction revealed a significant increase in excellent (p< 0.02) and poor (p< 0.03) results. Instrument failure correlated strongly with ODI (r=0.94, p< 0.04). No other significant correlations. Conclusions:With the correct patient selection, lumbar fusions for DSD’s lead to a significantly improved outcome at 2 years, with an acceptable complication rate. There is no correlation between radiographic fusion and outcome, but instrument failure leads to significantly worse outcome


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 245 - 245
1 Mar 2004
Ridgeway S Tai C Carey-Smith R Graevett-Ball C Harrison H
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Aims: To investigate the functional outcome with different autologous bone graft weights in posterolateral lumbar spine instrumentation for DSD’s. Methods: A total of 79 patients (mean age of 47.2) with chronic lower back pain for at least 2 years, with at least 1 year of failed conservative treatment and who were undergoing pos-terolateral spinal instrumentation for DSD’s were admitted to the trial. Patients were randomised into three groups to receive bone graft weights of 25g (Group A=26 patients), 50g (Group B=30 patients) and 100g (Group C=23 patients) per segment. Pain, clinical characteristics, disability (Oswestry), radiographic fusion, patient satisfaction and complications were recorded at 3, 6, 12 and 24-month follow-ups. Results: At 2 years, Group B (50g) had a significantly improved Oswestry Index, pain intensity, motor and sensory changes, and overall patient satisfaction than Group C (100g), which was significantly better than Group A (25g). There was no correlation between bone graft weight and radiographic fusion, between fusion and outcome, nor smoking and fusion or bone graft weight. Complications were similar. Conclusions: Patients had significantly better functional and clinical outcomes with bone graft weights of 50g. Bone graft weights of 25g had the worse outcomes and 100g did not seem to have any beneficial affect over 50g. We recommend autologous bone graft weights of 50g per fused spinal segments in this group of surgical patients.