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The Bone & Joint Journal
Vol. 101-B, Issue 8 | Pages 1024 - 1031
1 Aug 2019
Preoperative surgical risk stratification in osteosarcoma based on the proximity to the major vessels
Fujiwara T Medellin MR Sambri A Tsuda Y Balko J Sumathi V Gregory J Jeys L Abudu A
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Aims

The aim of this study was to determine the risk of local recurrence and survival in patients with osteosarcoma based on the proximity of the tumour to the major vessels.

Patients and Methods

A total of 226 patients with high-grade non-metastatic osteosarcoma in the limbs were investigated. Median age at diagnosis was 15 years (4 to 67) with the ratio of male to female patients being 1.5:1. The most common site of the tumour was the femur (n = 103) followed by tibia (n = 66). The vascular proximity was categorized based on the preoperative MRI after neoadjuvant chemotherapy into four types: type 1 > 5 mm; type 2 ≤ 5 mm, > 0 mm; type 3 attached; type 4 surrounded.

Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_3 | Pages 44 - 44
1 Apr 2018
THE DEGENERATION PROCESS ALTERS THE BIOMECHANICAL PROPERTIES OF MENISCAL TISSUE
Warnecke D Balko J Schild NB Wang P Bieger R Ignatius A Mizaikoff B Reichel H Dürselen L
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Introduction

With processing age, meniscus degeneration occurs which is often associated with osteoarthritis. Existing data about the influence of degeneration on the biomechanical properties of the meniscus are still contradictory, or completely unknown regarding the hydraulic permeability. Thus, the aim of this study was to characterise the biomechanical properties and structural composition of the meniscal tissue depending on its degree of degeneration.

Methods

Menisci of 24 TKR-patients (≈67.1 yrs.) were harvested and the degeneration of each region (pars anterior PA, pars intermedia PI, pars posterior PP) classified according to Pauli et al. For biomechanical characterisation, confined compression tests (20% strain; velocity: 3%h0/min, relaxation time: 1h) to determine equilibrium modulus (HA) and hydraulic permeability (k) and tensile tests (velocity: 5%l0/min) to determine the tensile modulus were performed. Therefore, cylindrical (Ø= 4.6mm, initial height h0≈ 2.3mm) and dumbbell-shaped (3.5mm × 1.4mm × 3.5mm) samples were punched out of each region and flattened to achieve parallel surfaces. Additionally, collagen and proteoglycan (PG) content were analysed by calculating the area-under-curve of their specific wavelength ranges (1293–1356cm−1 and 980–1120cm−1, respectively) using infrared (IR) spectroscopy. To identify differences regarding the meniscus regions or its degeneration, a statistically mixed model was used.