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Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_3 | Pages 15 - 15
1 Apr 2015
Brydone A Henderson F Allen D
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Since the establishment of our department a multi-modal approach to thromboprophylaxis that uses aspirin for chemical prophylaxis was adopted. In accordance with the latest national recommendations, our routine chemical prophylaxis following arthroplasty was changed to rivaroxaban in 2012 and then dalteparin in 2013.

This study aimed to compare venous thromboembolism (VTE) rates during the use of the aspirin-based protocol used from 2004 to 2011 with recent, rivaroxaban and dalteparin-based guidelines.

Outcome data from ISD Scotland was retrieved and radiology reports performed for CT pulmonary angiograms and lower limb doppler ultrasound scans in our institution were assessed to identify cases of VTE following primary hip or knee arthroplasty. The incidence of pulmonary embolism (PE) and proximal deep venous thrombosis (DVT) was calculated for each year and compared using a Chi-squared test. Additionally, the change in extended thromboprophylaxis regimen was surveyed by recording the discharge prescriptions for consecutive arthroplasty patients for March every year.

There were 90 radiologically confirmed cases of DVT or PE between 2004 and 2011 (incidence of 0.71%). The DVT/PE rate was subsequently 0.67% in 2012 and 0.69% in 2013, with a further 29 cases identified. This does not represent a significant change in the venous thromboembolism rates and remains below the national incidence of VTE (1.06%).

Aspirin alone was used as chemical thromboprophylaxis in 80.8% of patients from 2004 to 2011, 50.9% in 2012, and 12.1% in 2013.

The incidence of VTE at our centre remains favourable to national figures, but the modification of thromboprophylaxis guidelines will incur additional financial costs and has not had a significant reduction on the rate of VTE.


The Bone & Joint Journal
Vol. 96-B, Issue 11 | Pages 1515 - 1519
1 Nov 2014
Allen D Sale G

Although patients with a history of venous thromboembolism (VTE) who undergo lower limb joint replacement are thought to be at high risk of further VTE, the actual rate of recurrence has not been reported.

The purpose of this study was to identify the recurrence rate of VTE in patients who had undergone lower limb joint replacement, and to compare it with that of patients who had undergone a joint replacement without a history of VTE.

From a pool of 6646 arthroplasty procedures (3344 TKR, 2907 THR, 243 revision THR, 152 revision TKR) in 5967 patients (68% female, mean age 67.7; 21 to 96) carried out between 2009 and 2011, we retrospectively identified 118 consecutive treatment episodes in 106 patients (65% female, mean age 70; 51 to 88,) who had suffered a previous VTE. Despite mechanical prophylaxis and anticoagulation with warfarin, we had four recurrences by three months (3.4% of 118) and six by one year (5.1% of 118). In comparison, in all our other joint replacements the rate of VTE was 0.54% (35/6528).

The relative risk of a VTE by 90 days in patients who had undergone a joint replacement with a history of VTE compared with those with a joint replacement and no history of VTE was 6.3 (95% confidence interval, 2.3 to 17.5). There were five complications in the previous VTE group related to bleeding or over-anticoagulation.

Cite this article: Bone Joint J 2014;96-B:1515–19.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_3 | Pages 14 - 14
1 Feb 2014
Allen D Panousis K
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Patients with a history of venous thromboembolism (VTE) are considered at very high risk for recurrence after lower limb arthroplasty (LLA). However, the chance of a new VTE episode after LLA has not been yet quantified. The aim of this study was to define the incidence of VTE recurrence following knee and hip arthroplasty.

The case notes for all LLA patients treated at our hospital from 2009 to 2011 were reviewed. There were 5946 primary and revision LLA operations in total; 118 of these interventions were performed in 106 patients with a history of VTE. This group included 69 females and 37 males with a mean age of 69.9. Routine thromboprophylaxis for LLA patients included mechanical (footpumps & TED stockings) plus chemical prophylaxis using Aspirin 150 mg for 6 weeks. Patients with a VTE history had the same mechanical prophylaxis but received warfarin for 3 months.

There were no fatal VTEs within 90 days of surgery. There were 5 episodes (4.2%) of VTE recurrence and specifically 4 PE and one DVT (femoral vein) at 4 months after the operation. Two of the PEs were asymptomatic, diagnosed on CTPA scans being requested for low O2 saturations on routine monitoring. In the group of patients without a VTE history there were 35 VTE episodes (0.6%), indicating a significantly lower rate of VTE (p=0.001) in comparison with the study group.

Patients with a history of VTE had a 4.2% chance of having a further VTE. This is seven times greater than the rate among all other patients despite using more aggressive chemoprophylaxis.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXVI | Pages 78 - 78
1 Jun 2012
Mathieson C Jigajinni M McLean A Purcell M Fraser M Allen D Brown J Alakandy L
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Purpose

Patients with ankylosing spondylitis (AS) are vulnerable to cervical spine injury following relatively minor trauma. The authors present a retrospective review to determine the characteristics, treatment and outcome following cervical spine injury in these patients.

Methods

Retrospective analysis of case notes and images of patients with AS admitted to the Spinal Injury Unit over a 10-year period.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 250 - 250
1 Jul 2011
Beaulé P Allen D Doucette S Ramadan O
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Purpose: Femoroacetabular impingement (FAI) has recently been described as a cause of adult hip pain and a precursor of hip osteoarthritis. Pincer type is secondary to acetabular retroversion or coxa profunda and Cam type is secondary to lack of concavity/offset of the antero-lateral femoral head-neck junction. Purpose of this study was to determine the prevalence of bilateral deformity in patients with cam type FAI as well as the presence of associated acetabular abnormalities.

Method: One hundred and thirteen patients with symptomatic cam impingement (alpha (α) angle of Notzli > 55.5°) of at least one hip were evaluated. Eighty-two males, 31 females with an average age of 37.9 yrs (16–55). Standardized AP pelvis and bilateral Dunn views were reviewed. Alpha angle of Notzli was measured on Dunn views. Cam impingement was defined by α angle > 55.5 on the Dunn view and Pincer impingement was defined by the presence of either acetabular retroversion or coxa profunda. Statistical analysis was done using the two tailed paired t-test, chi-square test and intra-class correlation coefficient. Odds Ratios were calculated using conditional logistic regression.

Results: Eighty-eight patients (77.8%) had bilateral deformity and 27% had symptoms in both hips. Mean α angles were higher for bilateral impingement deformity than for the impingement side only when unilateral deformity was present (72.10 versus 64.50, p< 0.001). Forty-four percent of hips with an impingement deformity also had a pincer deformity, either acetabular retroversion or coxa profunda. Painful hips had a statistically significant higher mean alpha angle than asymptomatic ones (69.70 versus 63.10, p< 0.001)). Comparing hips with α angles of 61–70 with those < 60 found an odds ratio of being painful of 2.59 (95% CI: 1.32–5.08, p=0.006). Hips with α angles > 71 had an odds ratio of being painful of 2.54 (95% CI: 1.3–4.96, p=0.007).

Conclusion: The majority of patients with cam type FAI have bilateral deformities and an associated acetabular deformity less commonly. The severity of the deformity at the femoral head neck junction is a significant determining factor for the development of hip symptoms. This information is important as we better define the natural history of this deformity as well as devise effective treatment strategies.


The Journal of Bone & Joint Surgery British Volume
Vol. 91-B, Issue 5 | Pages 589 - 594
1 May 2009
Allen D Beaulé PE Ramadan O Doucette S

Femoroacetabular impingement is a cause of hip pain in adults and is potentially a precursor of osteoarthritis. Our aim in this study was to determine the prevalence of bilateral deformity in patients with symptomatic cam-type femoroacetabular impingement as well as the presence of associated acetabular abnormalities and hip pain. We included all patients aged 55 years or less seen by the senior author for hip pain, with at least one anteroposterior and lateral pelvic radiograph available. All patients with dysplasia and/or arthritis were excluded. A total of 113 patients with a symptomatic cam-impingement deformity of at least one hip was evaluated. There were 82 men and 31 women with a mean age of 37.9 years (16 to 55).

Bilateral cam-type deformity was present in 88 patients (77.8%) while only 23 of those (26.1%) had bilateral hip pain. Painful hips had a statistically significant higher mean alpha angle than asymptomatic hips (69.9° vs 63.1°, p < 0.001). Hips with an alpha angle of more than 60° had an odds ratio of being painful of 2.59 (95% confidence interval 1.32 to 5.08, p = 0.006) compared with those with an alpha angle of less than 60°. Of the 201 hips with a cam-impingement deformity 42% (84) also had a pincer deformity.

Most patients with cam-type femoroacetabular impingement had bilateral deformities and there was an associated acetabular deformity in 84 of 201 patients (42%). This information is important in order to define the natural history of these deformities, and to determine treatment.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_II | Pages 190 - 191
1 Jul 2002
Wigderowitz C Allen D Hilmi O Dent J
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The Souter-Strathclyde total elbow has been used in our unit since 1989. The current study reviews the results of the first 10 years of practice and compares them with reported results. Pain relief, complication rate, functional outcome and patient satisfaction were evaluated.

The primary indication for replacement was pain in the presence of advanced rheumatoid destruction of the joint on radiography, classified according to Souter (1989). Complications had been dealt with as appropriate, reviewed retrospectively and classified according to Dent et al (1995). Pain, activities of daily living and overall satisfaction were assessed by questionnaire. They were measured clinically for range of movement, power, stability and elbow performance using the Mayo Elbow Performance Score. Follow up x-rays were assessed for evidence of loosening. Fifty elbows were replaced in 43 patients, 34 female and nine male. There were 24 right and 26 left elbows. All patients had rheumatoid arthritis; one patient had an associated traumatic injury to the elbow. The pre-operative radiographs available for review were 10 grade 3, 12 grade 4 and 17 grade 5. The mean age of the patients was 65 years (range: 33–83 years). The average follow up was five years (range: 1-10 years). Fourteen patients died and one was lost to follow up, leaving 33 elbows in 28 patients. There were 12 complications, eight were type A, four elbows had a transient radial palsy, three had ulnar neuritis and there was one pressure sore. The only type B complication was a persisting subluxation in extension. There were three type C complications with early revision, a humeral fracture revised to a humeral resection implant, a subluxated joint revised to an ulnar retentive prosthesis and one deep infection revised to an excision arthroplasty. Twenty-four had no pain, six had occasional pain, one got pain with heavy use and two had pain at night. For ADL, two patients could not reach their mouth with difficult feeding and five had trouble toileting. All were able to dress themselves and turn taps. The preoperative range motion was 110° (±23.1°) Flex., 40° (±11.5°) Ext., 45° (±12.2°) Pron., and 46° (±36.9°) Sup. Postoperatively the mean ranges were 131° (±13.1°) Flex., 32° (±16°) Ext., 81° (±14°) Pron. and 72° (±32°) supination. By the Mayo performance score 67% had excellent results, 8% had good results, 17% fair and 8% poor. 67% of patients were extremely pleased with their results and only one was dissatisfied. No elbows had radiological evidence of loosening requiring revision.

There was substantial pain relief and an increase in the range of motion. The number of complications was acceptable and the patient satisfaction level was very high. The Souter-Strathclyde elbow arthroplasty is an appropriate option in rheumatoid patients with elbow destruction.