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Bone & Joint Research
Vol. 8, Issue 2 | Pages 101 - 106
1 Feb 2019
Patient-specific meniscus prototype based on 3D bioprinting of human cell-laden scaffold
Filardo G Petretta M Cavallo C Roseti L Durante S Albisinni U Grigolo B
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Objectives

Meniscal injuries are often associated with an active lifestyle. The damage of meniscal tissue puts young patients at higher risk of undergoing meniscal surgery and, therefore, at higher risk of osteoarthritis. In this study, we undertook proof-of-concept research to develop a cellularized human meniscus by using 3D bioprinting technology.

Methods

A 3D model of bioengineered medial meniscus tissue was created, based on MRI scans of a human volunteer. The Digital Imaging and Communications in Medicine (DICOM) data from these MRI scans were processed using dedicated software, in order to obtain an STL model of the structure. The chosen 3D Discovery printing tool was a microvalve-based inkjet printhead. Primary mesenchymal stem cells (MSCs) were isolated from bone marrow and embedded in a collagen-based bio-ink before printing. LIVE/DEAD assay was performed on realized cell-laden constructs carrying MSCs in order to evaluate cell distribution and viability.

Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 186 - 186
1 Jul 2014
FE-BASED BONE STRENGTH CAN CLASSIFY PROXIMAL FEMUR FRACTURES IN A CASE-CONTROL RETROSPECTIVE STUDY
Falcinelli C Schileo E Balistreri L Baruffaldi F Toni A Albisinni U Ceccarelli F Milandri L Viceconti M Taddei F
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Summary Statement

In a retrospective study, FE-based bone strength from CT data showed a greater ability than aBMD to discriminate proximal femur fractures versus controls.

Introduction

Personalised Finite Element (FE) models from Computed Tomography (CT) data are superior to bone mineral density (BMD) in predicting proximal femoral strength in vitro [Cody, 1999]. However, results similar to BMD were obtained in vivo, in retrospective classification of generic prevalent fractures [Amin, 2011] and in prospective classification of femoral fractures [Orwoll, 2009]. The aim of this work is to test, in a case-control retrospective study, the ability of a different, validated FE modelling procedure [Schileo, 2008] to: (i) discriminate between groups of proximal femoral fractures and controls; (ii) individually classify fractures and controls.

Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 47 - 47
1 Jul 2014
PREVALENCE OF PINCER-LIKE RADIOGRAPHIC PATTERNS AMONG GENERAL POPULATION: A CT AND X-RAY BASED DESCRIPTIVE STUDY ON 118 INDIVIDUALS
Trisolino G Strazzari A Stagni C Tedesco G Albisinni U Martucci E Dallari D
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Summary Statement

Pincer deformities are involved in the genesis of femoro-acetabular impingement (FAI). Radiographic patterns suggestive of pincer deformities are common among general population. Prevalence of the pincer deformities among general population may be overestimated if only plain radiographs are considered.

Background

Pincer deformities (coxa profunda, protrusio acetabuli, global retroversion, isolated cranial over-coverage) have been advocated as a cause of femoro-acetabular impingement (FAI) and early hip osteoarthritis (OA). Different radiographic patterns may advocate the presence of a pincer deformity. The prevalence of these radiographic patterns among general adult population, as their role in early hip OA, is poorly defined.