Ultra-High Molecular Weight Polyethylene (UHMWPE) can be made radiopaque through the diffusion of an oil-based contrast agent (Lipiodol Ultra-fluid). A similar process is used for Vitamin E incorporated polyethylene, which has a well-established clinical history. This study aimed to quantify the leaching of Lipiodol and compare to vitamin E polyethylene. GUR 1050 polyethylene (4 mm thickness) was cut into squares, 10 mm2. Samples (n=5) were immersed in 25 ml Lipiodol (Guerbet, France), or 15 ml Vitamin E (L-atocopherol, Sigma-Aldrich, UK). To facilitate diffusion, samples were held at 105°C for 18 hours. After treatment, all samples were immersed in DMEM (Sigma-Aldrich, UK) with Penicillin Streptomycin (Sigma-Aldrich, Kent, UK) at 4%v/v and held at 37°C in an incubator. Untreated polyethylene samples were included as controls. Leaching was quantified gravimetrically at weeks 2, 4 and 8. The radiopacity of the Lipiodol-diffused samples was investigated from µCT images (162kV, resolution 0.2 mm, X Tec, XT H 225 ST, Nikon Metrology, UK).Abstract
Objectives
Method
Oil-based fluids can be used to enhance the properties of polyethylene materials. For example, vitamin E infused polyethylene has a superior oxidation resistance and Lipiodol infused polyethylene has an enhanced X-ray attenuation. The aim of this study was to evaluate the long-term influence of oily fluid on the chemical, physical and tensile properties of polyethylene. An accelerated ageing procedure (an elevated temperature (80°C) for four weeks in air1) was used to investigate the oxidative stability (ASTM F2012-17)2, tensile (ISO 527)3 and thermal properties4 of oil treated polyethylene (n=5, GUR 1050, Celanese, Germany)and compared with clinically used polyethylene controls (oil-free standard and thermally treated polyethylene). All the experiments were performed on aged and unaged specimens in accordance to international standards and compared to currently available literature. A Kruskal-Wallis test was performed using a custom MATLAB code (R2017a, USA); with p < 0.05 considered statistically significant.Abstract
Objectives
Methods
Ultra-high molecular weight polyethylene (UHMWPE) is a commonly used as bearing material in joint replacement devices. UHMWPE implants can be hard to see on a standard X-ray because UHMWPE does not readily attenuate X-rays. Radiopaque UHMWPE would enable direct imaging of the bearing both during and after surgery, providing in vivo assessment of bearing position, dislocation or fracture, and potentially a direct measure of wear. The X-ray attenuation of UHMWPE was increased by diffusing an FDA approved contrast agent (Lipiodol) into UHMWPE parts (Zaribaf et al, 2018). The aim of this study was to evaluate the optimal level of radiopacity for a UHMWPE bearing. Samples of un-irradiated medical grade UHMWPE (GUR 1050) were machined into 4mm standard medium Oxford Unicompartmental bearings. Samples were immersed in Lipiodol Ultra Fluid (Guerbert, France) at elevated temperatures (85 °C, 95 °C and 105 °C) for 24 h to achieve three different levels of radiopacity. A phantom set-up was used for X-ray imaging; the phantom contained two perspex rods to represent bone, with the metallic tibial tray and polyethylene bearing fixed to the end of one rod and the metallic femoral component fixed to the other rod. Radiographs of the samples were taken (n=5) with the components positioned in full extension. To ensure consistency, the images of all the samples were taken simultaneously alongside an untreated part. The results of our ongoing study demonstrate that the radiopacity of UHMWPE can be enhanced using Lipiodol and the parts are visible in a clinical radiographs. The identification of the optimal treatment from a clinical perspective is ongoing; we are currently running a survey with clinicians to find the consensus on the optimal radiopacity taking into account the metallic components and alignment. Future work will involve a RSA study to assess the feasibility of measuring wear directly from the bearing.
