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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_14 | Pages 6 - 6
1 Nov 2021
Edwards T Maslivec A Ng G Woringer M Wiik A Cobb J
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Patients may be able to return to higher level activities following hip arthroplasty with modern techniques and prostheses, but the Oxford hip score, the standard PROM used by the NJS exhibits severe skew and kurtosis. The commonest score is 48/48. Most patients score above 40 preventing any discrimination between approaches or prostheses. We therefore sought both subjective and objective metrics which were relevant and valid without skew or high kurtosis in postoperative patients. The Metabolic Equivalent of Task (MET) reports energy usage in kcal/min burnt across a range of activities, condensed into a score of 0–25. A MET over 8 is considered ‘conditioning exercise’ tethered to life expectancy. A 2 point difference in average MET is considered a clinically relevant difference. Walking speed is a simple valid metric tethered to life expectancy, with a 0.1m/sec difference in walking speed equates to a clinically important difference.

Oxford Hip Score (OHS), and the MET were prospectively recorded in 221 primary hip arthroplasty procedures pre-operatively and at 1-year using a web based application. Pre and postoperative Gait analysis was undertaken on a subgroup of 34 patients, in comparison with age and sex matched controls.

Post-operatively, the OHS demonstrated significant skewed distributions with ceiling effects of 41% scoring 48/48. The MET was normally distributed around a mean of 10.3, with a standard deviation of 3.8 and no ceiling effect. Walking speed was normally distributed around a mean of 1.8m/sec, with a standard deviation was 0.15 m/sec

The MET is a simple patient reported score, which is normally distributed in patients following hip arthroplasty, around a mean of 10.3 with a standard deviation of 3.8. This valid activity metric correlates well with fast walking speed. This is also normally distributed with a standard deviation of over 0.1m/sec confirming low kurtosis. These simple measures have face validity: undertaking less active pastimes and being unable to keep up with other walkers are obviously inadvisable. The normal kurtosis of these metrics suggest that they may able to detect clinically relevant differences in outcome which are undetectable with commonly used PROMs. For surgeons developing less invasive approaches or using novel stems, these measures may detect clinically important improvements undetectable by the Oxford Hip Score.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_2 | Pages 26 - 26
1 Jan 2019
Choudhury A Auvient E Iranpour F Lambkin R Wiik A Hing C Cobb J
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Patellofemoral osteoarthritis (PFOA) affects 32% men and 36% women over the age of 60years and is associated with anterior knee pain, stiffness, and poor mobility. Patellofemoral arthroplasty (PFA) is a bone-sparing treatment for isolated PFOA. This study set out to investigate the relationship between patient-related outcome measures (PROMs) and measurements obtained from gait analysis before and after PFA. There are currently no studies relating to gait analysis and PFA available in the literature

A prospective cohort study was conducted of ten patients known to have isolated PFOA who had undergone PFA compared to a gender and age matched control group. The patients were also asked to complete questionnaires (Oxford knee score (OKS), EQ-5D-5L) before surgery and one year after surgery. Gait analysis was done on an instrumented treadmill comparing Ground reaction force parameters between the control and pre and post-operative PFA patients

The average age 60 (49–69) years with a female to male ratio of 9:1. Patient and healthy subjects were matched for age and gender, with no significant difference in BMI. Post-op PFA improvement in gait seen in ground reaction force at 6.5km/h. Base support difference was statistically significant both on the flat P=0.0001 and uphill P=0.429 (5% inclination) and P=0.0062 (10% inclination). PROMS response rate was 70%(7/10) pre-operative and 60%(6/10) post-operative. EQ-5D-5L scores reflected patient health state was better post-operatively.

This study found that gait analysis provides an objective measure of functional gait and reflected by significant quality-of-life improvement of patients post PFA. Literature lacks studies relating to gait-analysis and PFA. Valuable information provided by this study highlights that PFA has a beneficial outcome reflected by PROMs and improvement in vertical ground reaction force and gait

Further research is needed to assess how care-providers may use gait-analysis as part of patient care plans for PFOA patients.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_4 | Pages 18 - 18
1 Apr 2018
Farrokhnik R Wiik A Brevadt M Lambkin R Cobb J
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The use of hip resurfacing arthroplasty (HRA) has largely regressed due to the fear of metal-on-metal bearings. However committed HRA users continue to assert the functional advantages that a geometry retaining implant would have on a patient”s hip. Currently worldwide, HRA is only recommended to men who demand an active lifestyle. Despite this precarious indication, it is not clear to what extent HRA has on higher activity function. The aim of this study was to determine the functional extent to which could be achieved with HRA. The primary objective is to assess the loading pattern change for patients implanted with HRA at high walking speeds and inclinations. The second objective is to compare their loading features to a healthy group to determine if a normal gait pattern could be achieved.

Between 2012 and 2016, a total of 28 prospective unilateral HRA patients were analysed on an instrumented treadmill from a single centre. All 28 patient patients had a uniform implant type and had no other lower limb operations or disease. Perioperative plain orthogonal radiographs were used to measure hip length and global hip offset change. A healthy control group (n=35) were analysed to compare. All HRA patients gait characteristics were assessed at incrementally higher speeds and inclinations to determine the extent of improvement HRA has on a challenging activity. A Student t-test along with a multivariate analysis was done with significance set at α=0.05. Weight and height variance was accounted with Hof normalisation.

The HRA and control group were reasonably matched for age (57 vs 55yrs), BMI (27 vs 25) and height (175 vs 170cm) respectively. Hip measurements revealed less than 5mm change for all cases. The mean time from initial preoperative gait assessment to postoperative assessment was 30 months (24–48months). The mean top walking speed for controls was 1.97m/s and postoperatively 2.1 m/sec for the HRA group. The significant (p<0.001) loading change during flat walking can be seen with restoration of symmetry. Walking at an inclination demonstrated a marked change during weight acceptance (p<0.001) and a loading pattern returning to near normal.

This prospective study found HRA patients walking faster than age matched controls. They demonstrated a significant change in their loading pattern, by significantly shifting load from the unaffected side to the implanted side. Uphill walking, an activity which requires more hip flexion, demonstrated a change in stance phase which was near normal. This small comparative study confirms near physiological function can be achieved with HRA at higher activity levels.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_3 | Pages 76 - 76
1 Feb 2017
Cobb J Wiik A Brevadt MJ Auvinet E Van Der Straeten C
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Intro

Across much of medicine, activity levels predict life expectancy, with low levels of activity being associated with increased mortality, and higher levels of activity being associated with longer healthier lives. Resurfacing is a technically demanding procedure that has suffered significant fallout from the failure of a couple of poorly performing designs. However strong evidence associates resurfacing with improved life expectancy in both the short and longer term following surgery.

We wondered if there was any relationship between the function of hips following surgery and the extent of that surgery. Could a longer stem inside the femur be the reason for a slightly reduced step length? We proposed the nul hypothesis that there was no clinically relevant difference between stem length and gait.

Method

After informed consent each subject was allowed a 5 minute acclimatisation period at 4km/hr on the instrumented treadmill (Kistler Gaitway, Amherst, NY). Their gait performance on an increasing incline at 5, 10 and 15%. At all 0.5km incremental intervals of speed, the vertical component of the ground reaction forces, center of pressure and temporal measurements were collected for both limbs with a sampling frequency of 100Hz over 10sec.

They were also asked to log onto our JointPRO website and report their function using Oxford, EQ5D, and Imperial scores.

Owing to current restrictions in indications, the patient groups selected were not comparable. However, from our database of over 800 patients who have been through the gait lab. 82 subjects were tested from 2 diagnostic groups (29 conventional THR, 27 hip resurfacing) and compared with a slightly younger group of 26 healthy controls. Patients were excluded if less than 12 months postop, or with any other documented joint disease or medical comorbidities which might affect gait performance.

Body weight scaling was also applied to the outputted mechanical data to correct for mass differences. All variables for each subject group were compared to each other using an analysis of variance (ANOVA) with Tukey post hoc test with significance set at α=0.05.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_4 | Pages 34 - 34
1 Feb 2017
Brevadt MJ Wiik A Aqil A Auvinet E Loh C Johal H Van Der Straeten C Cobb J
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Introduction

Financial and human cost effectiveness is an increasing evident outcome measure of surgical innovation. Considering the human element, the aim is to restore the individual to their “normal” state by sparing anatomy without compromising implant performance. Gait lab studies have shown differences between different implants at top walking speed, but none to our knowledge have analysed differing total hip replacement patients through the entire range of gait speed and incline to show differences. The purpose of this gait study was to 1) determine if a new short stem femoral implant would return patients back to normal 2) compare its performance to established hip resurfacing and long stem total hip replacement (THR) implants.

Method

110 subjects were tested on an instrumented treadmill (Kistler Gaitway), 4 groups (short-stem THR, long-stem THR, hip resurfacing and healthy controls) of 28, 29, 27, and 26 respectively. The new short femoral stem patients (Furlong Evolution, JRI) were taken from the ongoing Evolution Hip trial that have been tested on the treadmill minimum 12months postop. The long stem total hip replacements and hip resurfacing groups were identified from our 800+ patient treadmill database, and only included with tests minimum 12 months postop and had no other joint disease or medical comorbidities which would affect gait performance.

All subjects were tested through their entire range of gait speeds and incline after having a 5 minute habituation period. Speed were increased 0.5kmh until maximum walking speed achieved and inclines at 4kmh for 5,10,15%. At all incremental intervals of speed 10seconds ere collected, including vertical ground reaction forces (normalized to body mass), center of pressure and temporal measurements were for both limbs (fs=100Hz). Symmetry Index(SI) were calculated on a range of features comparing leg with implanted hip to the contralateral normal hip. Group means for each feature for each subject group were compared using an analysis of variance (ANOVA) with Tukey post-hoc test with significance set at α=0.05.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_1 | Pages 5 - 5
1 Jan 2017
Brevadt M Wiik A Aqil A Johal H Van Der Straeten C Cobb J
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Financial and human cost effectiveness is an increasing evident outcome measure of surgical innovation. Considering the human element, the aim is to restore the individual to their “normal” state by sparing anatomy without compromising implant performance. Gait lab studies have shown differences between different implants at top walking speed, but none to our knowledge have analysed differing total hip replacement patients through the entire range of gait speed and incline to show differences. The purpose of this gait study was to 1) determine if a new short stem femoral implant would return patients back to normal 2) compare its performance to established hip resurfacing and long stem total hip replacement (THR) implants.

110 subjects were tested on an instrumented treadmill (Kistler Gaitway, Amherst, NY), 4 groups (short-stem THR, long-stem THR, hip resurfacing and healthy controls) of 28, 29, 27, and 26 respectively. The new short femoral stem patients (Furlong Evolution, JRI) were taken from the ongoing Evolution Hip trial that have been tested on the treadmill with minimum 12months postop. The long stem total hip replacements and hip resurfacing groups were identified from out 800 patient gait database. They were only chosen if they were 12 months postop and had no other joint disease or medical comorbidities which would affect gait performance.

All subjects were tested through their entire range of gait speeds and incline after having a 5 minute habituation period. Speed intervals were at 0.5kms increments until maximum walking speed achieved and inclines at 4kms for 5, 10, 15%. At all incremental intervals of speed, the vertical component of the ground reaction forces, center of pressure and temporal measurements were collected for both limbs with a sampling frequency of 100Hz. Body weight scaling was applied to correct for mass differences and a symmetry index to compare the implanted hip to the contralateral normal hip. All variables for each subject group were compared to each other using an analysis of variance (ANOVA) with Tukey post hoc test with significance set at α=0.05.

The four experimental groups were reasonably matched for demographics and the implant groups for PROMs. Hip resurfacing had a clear top walking speed advantage, but when assessing the symmetry index on all speeds and incline, all groups were not significantly different. Push-off and step length was statistically less favourable for the short/long THR group (p=0.005–0.05) depending on speed/incline.

The primary aim of this study was determine if implant design affected gait symmetry and performance. Interestingly, irrespective of implant design, symmetry with regards to weight acceptance, impulse, push-off and step length was returned to normal when comparing to healthy controls. However individual implant performance on the flat and incline, showed inferior (p<0.05) push-off force and step length in the short stem and long stem THR groups when compared to controls. Age and gender may have played a part for the short stem group. It appears that the early gait outcomes for the short stem device are promising. Assessment at the 3 year mark should be conclusive.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_8 | Pages 58 - 58
1 May 2016
Brevadt M Manning V Wiik A Aqil A Dadia S Cobb J
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Introduction

Femoral component design is a key part of hip arthroplasty performance. We have previously reported that a hip resurfacing offered functional improved performance over a long stem. However resurfacing is not popular for many reasons, so there is a growing trend towards shorter femoral stems, which have the added benefit of ease of introduction through less invasive incisions. Concern is also developing about the impact of longer stems on lifetime risk of periprosthetic fracture, which should be reduced by the use of a shorter stem. For these reasons, we wanted to know whether a shorter stem offered any functional improvement over a conventional long stem. We surmised that longer stems in hip implants might stiffen the femoral shaft, altering the mechanical properties.

Materials and Methods

From our database of over 800 patients who have been tested in the lab, we identified 95 patients with a hip replacement performed on only one side, with no other lower limb co-morbidities, and a control group:

19 with long stem implant, age 66 ± 14 (LONG)

40 with short stem implant, age 69 ± 9 (SHORT)

26 with resurfacing, age 60 ± 8 (RESURF)

43 healthy control with no history of arthroplasty, age 59 ± 10 (CONTROL)

All groups were matched for BMI and gender.

Participants were asked to walk on an instrumented treadmill. Initially a 5 minute warm up at 4 km/h, then tests at increasing speed in 0.5 km/h increments. Maximum walking speed was determined by the patients themselves, or when subjects moved from walking to running.

Ground reaction forces (GRF) were measured in 20 second intervals at each speed. Features were calculated based on the mean GRF for each trial, and on symmetry measures such as first peak force (heel strike), second peak force (toe-off), the rate at which the foot was loaded and unloaded, and step length.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_7 | Pages 89 - 89
1 May 2016
Cobb J Collins R Wiik A Brevadt M Auvinet E Manning V
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Any arthroplasty that offers superior function needs to be assessed using metrics that are capable of detecting those functions. The Oxford Hip Score (OHS), the Harris Hip Score (HHS) and WOMAC are patient reported outcome measures (PROMs) with well documented ceiling effects: following hip arthroplasty, many patients are clustered close to full marks following surgery. Two recent well conducted randomised clinical trials made exactly this error, by using OHS and WOMAC to detect a differences in outcome between hip resurfacing and hip arthroplasty despite published data already showing in single arm studies that these two procedures score close to full marks using either of these PROMS.

We have already reported that patients with hip resurfacing arthroplasty (HRA) were able to walk faster and with more normal stride length than patients with well performing hip replacements. In an attempt to relate this functional superiority to an outcome measure that does not rely upon the use of expensive machinery, we developed a patient centred outcome measure (PCOM) based upon a method developed by Philip Noble's group, and the University of Arizona's Metabolic Equivalent of Task Index (MET). This PCOM allows patients to select the functions that matter to them personally against which the success of their own operation will be measured, with greater sensitivity to intensity than is achieved by the UCLA.

Our null hypothesis was that this PCOM would be no more successful than the PROMs in routine use in discriminating between types of hip arthroplasty, and that there would be no difference in gait between patients following these procedures.

From our database of over 800 patients whose gait has been assessed in the lab, we identified 22 patients with a well performing conventional THAs, and matched them for age, sex, BMI, height, preop diagnosis with 22 patients with a well performing conventional THA. Both were compared with healthy controls using the novel PCOM and in a gait lab.

Results

PROMs for the two groups were almost identical, while HRA scored higher in the PCOM. The 9% difference was significant (p<0.05). At top walking speed, HRA were 10% faster, with a 9% longer stride length, both of these metrics also reached significance.

Discussion

Function following hip replacement is very good, with high satisfaction rates, but the use of a PCOM, and objective measures of function reveal substantial inferiority of THA over THR in two well matched groups. This 9% difference is well over the 5% difference that is considered ‘clinically relevant’. When coupled with the very strong data regarding life expectancy and infection, this functional data makes a compelling case for the use of resurfacing in active adults.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_1 | Pages 91 - 91
1 Jan 2016
Cobb J Boey J Manning V Wiik A
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Introduction

Our primary hypothesis was simple: does gait on a downhill gradient distinguish between types of knee arthroplasty? Our secondary hypotheses were these: are stride length and other kinematic variables affected by cruciate ligament integrity following knee arthroplasty?

Participants

Ethical approval was sought and gained prior to commencement of the study. 52 subjects were tested on the instrumented treadmill, 3 groups (UKA, TKA, and young healthy control) of 19, 14, and 19 respectively. The two high performing arthroplasty groups were recruited from a database of patient related outcome measures (PROMs) and were chosen based on high Oxford knee scores (OKS) with a minimum 12 months post hip arthroplasty.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 18 - 18
1 Jan 2013
Wiik A Tankard S Lewis A Krishnan S Amis A Cobb J
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Background

High functional aspirations and an active ageing population equate to a growing number of patients awaiting hip arthroplasty demanding superior biomechanical function. The purpose of this study was to compare the biomechanics of top walking speed between two commonly used hip arthroplasty procedures to determine if a performance advantage existed.

Methods

A retrospective comparative study was performed using sixty-seven subjects, twenty-two subjects in both hip resurfacing and total hip arthroplasty groups along with twenty-three healthy controls. All arthroplasty subjects were recruited based on high psychometric scoring and had been performed through a posterior approach, and had been discharged from follow-up. On an instrumented treadmill each subject was measured by a researcher blinded to which procedure that patient had undergone. After a six minute acclimatization period, the speed was increased incrementally until top walking performance had been attained. At all increments, ground reaction forces and temporospatial measurements were collected.