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Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_10 | Pages 29 - 29
1 Aug 2021
Fishley W Selvaratnam V Carluke I Partington P Reed M Kramer D Wilson M Hubble M Howell J Timperley A Whitehouse S Kassam A Petheram T
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Femoral cement-in-cement revision is a well described technique to reduce morbidity and complications in hip revision surgery. Traditional techniques for septic revision necessitate removal of all bone cement from the femur. In our two institutions, we have been using a cement-in-cement technique, leaving the distal femoral cement in selected cases for septic hip revision surgery.

Between February 2010 and September 2019, 89 patients with prosthetic hip infection underwent first or single stage procedures leaving the distal femoral cement in situ and performing a cement-in-cement revision. The mean patient age was 72.0 years (24–92). The median time from the last arthroplasty procedure was 29.0 months (1–294).

81 patients underwent revision using a cemented Exeter stem, 7 patients received an articulating spacer, and one patient underwent excision arthroplasty with the distal cement left in situ. Patients received clinical and radiographic follow-up with a mean of 42.8 months (range 11.0–120.1 months). Oxford hip scores were collected from each institution's existing databases.

9 patients (10.1%) died within one year of surgery. No deaths were directly related to joint infection or the surgery. One patient was lost to follow up before one year.

Of the remainder, 7 patients (8.9%) required further procedures for infection and were therefore considered to be treatment failures. 6 patients (7.6%) underwent planned second stage procedures with no recurrence of infection. 7 patients (8.9%) had further surgery for non-infective reasons. The Kaplan-Meier estimate of infection free survival at one year was 93.7% (95% CI 88.4 to 99.0%).

No patients underwent revision for stem loosening. Oxford hip scores were available at over one year postoperatively for 51 patients with a mean score of 30.6, and a mean gain of 11.9.

In our combined cohort of patients, cement-in-cement revision had an infection eradication rate of 91.1%. Patient selection is crucial, and the procedure can only be performed when there is a well-fixed cement mantle. However, when strict criteria are followed, this technique offers potential significant benefits to surgeons performing this challenging surgery, and more importantly the patients undergoing them.


Introduction

Analysis of registry data shows that few units achieve results better than 99·98% control limits. Implant selection is considered a predictor of outcome variation in joint replacement. We analysed the outcomes of a unit with statistically “better than expected” results and compared to all other units within the National Joint Registry for England, Wales, Northern Ireland and Isle of Man (NJR). We sought to determine whether improved implant survival following primary total hip replacement (THR) is a centre effect or mediated by implant selection.

Methods

We identified 664,761 THRs in the NJR. The exposure was the unit in which the THR was implanted and the outcome all-cause revision. Net failure was estimated using Kaplan-Meier and adjusted analyses used flexible parametric survival analysis.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_6 | Pages 22 - 22
1 May 2019
Takada R Whitehouse S Hubble M Wilson M Howell J Timperley A Kassam A
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Introduction

Varus alignment of the femoral component in total hip arthroplasty (THA) is thought to be a risk factor for implant loosening and early revision surgery. The purpose of this study was to evaluate whether the Exeter stem tolerates varus alignment and assess if this theoretical malalignment has an influence on clinical outcomes.

Methods

A total of 4126 consecutive THAs were reviewed for patients between 2006 and 2012 to allow for a minimum five-year follow-up. To determine the effects of the stem alignment on results, the hips were classified into 3 groups on the basis of stem alignment in initial postoperative anteroposterior radiographs. The alignment of the stem was defined as neutral, valgus (≥ 3° of lateral deviation), or varus (≥ 3° of medial deviation). The primary outcome was all cause revision with patient related outcomes assessed with Oxford hip score pre and post-operatively.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_6 | Pages 24 - 24
1 May 2019
Kassam A Whitehouse S Wilson M Hubble M Timperley A Howell J
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Introduction

Rationing of orthopaedic services is increasingly being used by Care Commissioning Groups (CCG) within the United Kingdom to restrict the numbers of patients being referred for Total Hip Arthroplasty (THA). In Devon, only patients with an Oxford Hip Score (OHS) less than 20 are referred on for specialist Orthopaedic Review. The aim of this study was to look at long term outcomes after THA to see if this rationing has any rational base to justify its use

Methods

Consecutive patients undergoing THA in Exeter between 1996 and 2012 had OHS' collected prospectively pre-operatively and a minimum of 4 years post-operatively. These scores were analysed looking for trends in patient related outcome scores.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_1 | Pages 41 - 41
1 Jan 2018
Timperley A Hanly R
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The SPAIRE technique (Spare Piriformis And Internus, Repair Externus) involves a muscle sparing mini-posterior approach to the hip.

Evidence will be prevented that the principle function of the “short external rotator” muscle group is primarily as an abductor and extensor of the flexed hip and has a profound influenced on weight bearing rising and propulsive motions; also that details of the insertions of the piriformis tendon and conjoint insertion of obturator internus and the gemelli (the Quadriceps Coxa) have previously been poorly appreciated. We have developed a surgical technique (SPAIRE) during which the only tendon released, and subsequently repaired, is obturator externus.

The author has carried out the SPAIRE technique for all routine hip arthroplasties for the last 18 months. This cohort has been compared with a matched control group for a comprehensive array of outcome measures. Results show no disadvantage of using the technique. On-table stability is so impressive that when the SPAIRE technique has been used no postoperative restrictions whatsoever are placed on the patient who is immediately encouraged to exercise the hip through a full excursion of movement.

Fewer tendons are damaged using the SPAIRE technique than any other approach to the hip including Direct Anterior and Direct Superior approaches. Randomised prospective studies are on-going using objective measurements of Gait and muscle power as well as functional and patient reported outcomes to prove benefit of the SPAIRE technique. For hemiarthroplasty cases a separate RCT is being undertaken comparing the SPAIRE technique with a direct lateral approach. It is believed that this technique may become the default technique for hemi- and total- hip arthroplasty through a posterior approach and for all hip fracture arthroplasty cases.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 38 - 38
1 Jun 2017
Cnudde P Nemes S Mohaddes M Timperley A Garellick G Burström K Rolfson O
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The risk of dying following total hip replacement (THR) is low and has declined over the last decades. The influence of comorbidities and worse physical status on mortality leads to the idea that patient-reported health status may also be a predictor of mortality. Although this has not been demonstrated in THR surgery, some studies in other fields have reported an association. The aim of this study was to investigate the relationship between patient-reported health status before THR and the risk of dying up to 5 years post-operatively.

The Swedish Hip Arthroplasty Register runs a nationwide PROMs program including the EQ-5D questionnaire to routinely monitor patients undergoing THR in Sweden. For these analyses, we used register data on 42,862 patients with hip osteoarthritis operated with THR between 2008 and 2012. Relative survival ratio was calculated by dividing the observed survival in the patient group by age- and gender-adjusted expected survival of the general population. Multivariable modelling proceeded with time-transformed Cox proportional hazards. Pre-operative responses to the five EQ-5D dimensions along with age, gender, education status, year of surgery, and hospital type were used as independent variables.

As a group THR patients had a better survival than the general population. Broken down by the five EQ-5D dimensions we observed differentiated survival patters. For all dimensions, those reporting moderate problems (level 2) had higher mortality than those reporting no problems (level 1) and those reporting extreme problems (level 3) had higher mortality than those reporting level 1 or 2.

Worse health status according to the EQ-5D before THR is associated with higher mortality up to five years after surgery. The complexity of the interactions between different patient-factors associated with outcomes complicates accurate assessments of risks and expected benefits for individual patients. EQ-5D responses may be useful in a multifactorial individualized risk assessment before THR.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 48 - 48
1 Jun 2017
Cnudde P Nemes S Bülow E Timperley A Kärrholm J Malchau H Garellick G Rolfson O
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Prospectively collected data is an important source of information subjected to change over time. What surgeons were doing in 1999 might not be the case anymore in 2016 and this change in time also applies to a number of factors related to the performance and outcome of total hip replacement. We evaluated the evolution of factors related to the patient, the surgical procedure, socio-economy and various outcome parameters after merging the databases of the Swedish Hip Arthroplasty Register, Statistics Sweden and the National Board of Health and Welfare.

Data on 193,253 THRs (164,113 patients) operated between 1999 and 2012 were merged with databases including general information about the Swedish population and about hospital care. We studied the evolution of surgical volume, patient demographics, socio-economic factors, surgical factors, length of stay, mortality rate, adverse events, re-operation and revision rates and PROMs.

Most patients were operated because of primary osteoarthritis and this share increased further during the period at the expense of decreasing number of patients with inflammatory OA and hip fracture. Comorbidity and ASA scores increased for each year. The share of all cemented implants has dropped from 92% to 68% with a corresponding increase of all uncemented from 2% to 16%.

Length of stay decreased with about 50 percent to 4.5 days in 2012. The 30- and 90-day mortality rate dropped to 0.4% and 0.7%. Re-operation and revision rates at 2 years were lower in the more recent years. The postoperative PROMs are improving despite the preoperative pain scores getting worse.

Even in Sweden, always been considered as a very conservative country with regards to hip replacement surgery, the demographics of the patients, the comorbidities and the primary diagnosis for surgery are changing. Despite these changes the outcomes like mortality, re-operations, revisions and PROMs are improving.


Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_12 | Pages 25 - 25
1 Jun 2017
Evans J Maggs J Smeatham A Charity J Timperley A
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When Radiolucent lines (RLL) are observed around cemented acetabular components, they may progress and be associated with loosening.

We reviewed the incidence and progression of RLLs around the Exeter Contemporary flanged acetabular component and compared our results with other published series.

We reviewed a consecutive series of 203 sockets with a minimum 10-year follow-up. Up to date radiographs were reviewed by 2 independent assessors for the presence, location and thickness of RLL and an assessment for loosening/migration was made. Initial post-operative radiographs were examined for any case with RLLs at review.

There were no revisions for aseptic loosening. 103 hips remained in situ with a minimum follow up of 10 years. Lucent lines were seen on 37/103 (36%) of hips with a mean follow up of 12.1 years (10.0–13.9 years). In these 37 hips, the lucency was present in one zone in 84%, two zones in 8% and all three zones in 8%.

Of the 37 hips with a RLL at minimum 10 years follow up, five exhibited a RLL immediately post-operatively. All 5 of these lines were initially isolated to zone 1 and progressed over the 10 years around at least 1 more zone. Only one line became circumferential, although the cup did not migrate.

Compared to previous papers (DeLee & Charnley, Hodgkinson and Garcia-Cimbrelo) the presence of RLL at 10 years is reduced in our series (table 2) and no cup migrated. All RLL seen in cups at both 10 years and immediate post-operatively in our series progressed (table 3), unlike in the previous studies. This reduction in lucent lines may be down to modern cementing techniques, cup design or a combination of both.

For any figures or tables, please contact the authors directly by clicking on ‘Info & Metrics’ above to access author contact details.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 31 - 31
1 Jun 2016
Westerman R Whitehouse S Howell J Hubble M Timperley A Wilson M
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Introduction

The Exeter Hip femoral component remains largely unchanged from the original design, introduced in 1970. It is a highly polished, modular, double tapered stem and has undergone various minor modifications to surface, modularity and most recently the taper; changed to the current V40TM design in 2000.

The effect of any design modification cannot easily be foreseen and greater emphasis is now placed on ensuring appropriate monitoring for such implants.

Methods

We present the results of the first 540 V40TM Exeter THAs performed in our Centre between December 2000 and May 2002. All patients were reviewed prospectively at 1, 5 and 10 years following surgery.


Orthopaedic Proceedings
Vol. 98-B, Issue SUPP_11 | Pages 1 - 1
1 Jun 2016
Hanly R Doyle F Whitehouse S Timperley A
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Introduction

Post-operative gait abnormalities are recognized following total hip arthroplasty (THA). Despite global improvement in functional outcome, gait abnormality persists for a decade or more. In this study 3-dimensional gait analysis (3DGA) was performed using a portable system with Inertial Measurement Units (IMUs) to quantify this abnormality.

Methods

The gait of 55 patients with monarthrodial hip arthrosis was measured pre-operatively and at one year post-surgery. Patients with medical co-morbidity or other conditions affecting their gait were excluded. Six IMUs were aligned at the level of the anterior superior iliac spines, mid-thigh and mid-leg. Data was analysed using proprietary software. Each patient underwent a conventional THA using a posterolateral approach. 92 healthy individuals were assessed for comparison.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 40 - 40
1 Nov 2015
Sathu A Timperley A Hubble M Wilson M Whitehouse S Howell J
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Introduction

There is sparse evidence regarding the survivorship beyond 20 years of both uncemented and cemented hip replacements in patients 50 years and under. We report a unique series reviewing 20–26 year follow-up of patients ≤50 years with cemented Exeter THR.

Materials and Methods

We reviewed the survivorship with clinical and radiological outcomes of 138 consecutive cemented THR's in 113 patients ≤50 years. The pre-op diagnoses included Osteoarthritis (30%), DDH (25%), RA (9%) and Post traumatic OA (5%), and 31% of patients had previous surgery to the hip. All patients were followed up at 5 year intervals and there was no patient lost to follow up.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 44 - 44
1 Nov 2015
Maggs J Smeatham A Charity J Whitehouse S Gie G Timperley A
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Introduction

We report on the outcome of a cemented flanged acetabular component at a minimum of 10 years post-operatively.

Patients/Materials & Methods

Two hundred and three hips were reviewed in 194 consecutive patients who underwent primary total hip arthroplasty using this implant. Cases with acetabular defects requiring bone grafting were excluded. Functional and radiological data were prospectively recorded.


Orthopaedic Proceedings
Vol. 97-B, Issue SUPP_12 | Pages 37 - 37
1 Nov 2015
Kazi H Whitehouse S Timperley A
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Introduction

Cemented stems have given good results with no difference in outcome when comparing taper slip and composite beam designs in short-term randomised trials. We aimed to ascertain differences in outcome between the different cemented design philosophies using a large-scale registry analysis.

Materials and Methods

A retrospective cohort study of National Joint Registry of England and Wales (NJREW) was conducted. The study population included all primary total hip operations performed in the UK from 1 April 2003 to 31 September 2012. All cemented stems were identified and categorised as taper slip (polished) or composite beam (non-polished).