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Orthopaedic Proceedings
Vol. 99-B, Issue SUPP_2 | Pages 102 - 102
1 Jan 2017
Gindraux F Lepage D Loisel F Nallet A Tropet Y Obert L
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Used routinely in maxillofacial reconstructive surgery, the chondrocostal graft is also applied to hand surgery in traumatic or pathologic indications. The purpose of this overview was to analyze at long-term follow-up the radiological and histological evolution of this autograft, in hand and wrist surgery. We extrapolated this autograft technique to the elbow by using perichondrium.

Since 1992, 148 patients have undergone chondrocostal autograft: 116 osteoarthritis of the thumb carpometacarpal joint, 18 radioscaphoid arthritis, 6 articular malunions of the distal radius, 4 kienbock's disease, and 4 traumatic loss of cartilage of the proximal interphalangeal (PIP) joint. Perichondrium autografts were used in 3 patients with elbow osteoarthritis.

Magnetic Resonance Imaging (MRI) was performed in 19 patients with a mean follow-up of 68 months (4–159). Histological studies were performed on: i) perioperative chondrocostal grafts (n=3), ii) chondrocostal grafts explanted between 2 and 48 months after surgery (n=10), and iii) perioperative perichondrium grafts (n=2).

Whatever the indication, the reconstruction by a chondrocostal/ostochondrocostal or perichondrium graft yielded satisfactory clinical results at long-term follow-up. The main question was the viability of the graft.

For rib cartilage grafting: The radiological study indicated the non-wear of the graft and a certain degree of ossification. The MRI and histology confirmed a very small degree of osseous metaplasia and graft viability. The biopsies showed neo-vascularization of the cartilage that had undergone morphological, constitutional and architectural changes. Comparison of these structural modifications with perioperative chondrocostal graft histology is in progress.

For perichondrium grafting: The first cases gave satisfactory clinical results but must be confirmed on a larger number of patients. Histological results highlighted a tissue composed of one fibrous layer and one cartilage-like layer, a common composition of supporting tissue.

Despite the strong mechanical strain in the hand and wrist, chondrocostal graft is a biological arthroplasty that is trustworthy and secure over the long term, although it can cause infrequent complications inherent to this type of surgery. Despite the inevitable histological modification, the cartilage remains alive and is of satisfactory quality at long term follow-up and fulfills the requirements for interposition and reconstruction of an articular surface.

The perichondrium graft constitutes a new arsenal to cure cartilage resurfacing. The importance of perichondrium for the survival of the grafted cartilage, as previously reported, as well as its role in resurfacing, is being investigated.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 119 - 119
1 Mar 2009
Obert L leclerc G daniel L tropet Y garbuio P
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PURPOSE: To compare the functionnal and radiological results concerning the “same” distal radius fracture of 3 different and consecutive procedure : dorsal plate, pins and palmar plate.

MATERIAL AND METHOD: Sixty two patients with a dorsally displaced extra-articular fracture of the distal radius were treated by dorsal plating [group 1, 20 patients, mean age 59,9 yo (25–87)], pinning [group 2, (22 patients, mean age 55,6 yo (17–83)] and volar plating [group 3, 20 patients mean age 57,1 yo (17–78)]. Patients were evaluated by a surgeon not involved in the treatment. Posttreatment evaluations consisted of measurements of range of motion, grip strength, radiographic evaluations between post operative time and last follow up, and evaluation by Herzberg scoring, associated with Gartland and Werley rating system and completion of Disability of Arm, Shoulder, and Hand questionnaires. Comparaison of three groups was performed with Kruskall-Wallis or ANOVA test (quantitatives variables) and Khi-2 (qualitatives variables) (p-value < 0.05).

RESULTS : Operative time was same for plate groups but two times more than pin groups. In Group 1 most complications and fair functionnal results were reported (32%) in spite highest follow up. Group 3 showed best results in flexion-extension, with DASH scoring, ulnar variance conservation, and most excellent and good results with Gartland and werley rating system. In group 2 and 3 same percentage of complications were pointed: 5%. Indenpendtly of tretament best results were reported in men, less than 30 yo.

DISCUSSION : If dorsal plate remains logical, such a fixation is challenging with high percentage of complications. In such extrarticular distal radius fracture palmar plate as pinning reach good and reliable functionnal results. Reduction of the palmar cortex remains probably the technical point. If the palmar plate is sufficiently rigid it can offer adequate stability for the treatment of the distal radius fracture in which the anterior and/or posterior metaphyseal cortex is frequently comminuted severely.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 178 - 178
1 Mar 2009
Obert L Lepage D Rochet S Klingelschmitt S Blagonoskonov O Tropet Y Garbuio P
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Introduction: Occult fractures of carpal bones are underestimed. To be treated succesfully fractures of the scaphoid must be identified at an early stage. A delay in detection may result in non union. We validated with 3 prospective studies a new tool using scintigraphy : The quantitative Xray bone scan (QRS)

Material and Methods: A previous preliminary prospective study with 60 patients was performed and published to valid the QRS as a step in diagnosis of wrist occult bones fractures equal to RMI. This exam is a bone scan with 2 improvments.

1) A quantification of the fixation spot : If the spot is two times more important on the injuried wrist (than controlateral side) the fracture is sure.

2) If you combine plain Xrays of the the wrist with scintigraphy the fracture is automatically located. This previous report pointed that repeat set of scaphoid views, dynamic and static, Ct scan, proved unsuitable for screening occult fractures of the wrist.

Result: Between november 97 and march 04, 667 patients were enrolled in a prospective continue study. 40% (260/667) of patients with an injury of the wrist with normal X ray sustained an occult fracture. QRS was performed at an average of 17,7 days after the injury and after clinical exam and repeat set of scaphoid view. Scaphoid fractures were most frequent. Fixation was most important if scintigraphy was performed between 11 and 20 days after the injury. Fixation did not depend on age, sex, volume of the bone, and delay (after 15 days).

Discussion: As Dikson, Dias, Thompson, and Kuckla, repeat set of scaphoid view are unable to improve significativally the number of occult fractures of the wrist. RMI as reported by Kuckla can reduce the need for further imaging procedure. RMI and scintigraphy are both the best exam to diagnose surely an occult fracture of the wrist. But QRS does not over diagnose, as RMI, bones fracture’s.

Conclusion: “Plaster cast and wait” is not the treatment for occult carpal bones fracture’s. The quantitative Xray bone scan is able to diagnose such fractures with short delay.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 178 - 178
1 Mar 2009
Obert L Lepage D Rochet S Gallinet D Garbuio P Tropet Y
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Objective: 6 cases of postraumatic arthritis of the distal radius treated by chondro costal graft are reported with a minimum follow up of 2 years

Material and methods: 6 patients (One 22 years old patient with a dislocated radiocarpal joint 6 months after an injury, 3 patients (48, 52 and 53 years old) respectively 1, 1,5 and 2 years after a intraarticular fracture of distal radius and a patient (74 years old) with radio lunate arthritis reported two mains complaints : pain and stiffness. The last patient was a female with a destruction of radio scaphoid joint after septic complication of scaphoid surgery. Location of the cartilage defect was central in two cases and palmar in the others. A dorsal approach in one case, a palmar approach in the five others allowed reduction and reconstruction of the destroyed radial part of joint. An osteochondro costal graft harvested on the eight’s rib was inserted and fixed by plate in place of the articular impaction. Plaster cast of 3 months in the first case and 1 month in the others cases followed the articular reconstruction

Results : No complication have been pointed. Union was achieved in all 6 cases. Integration and viability of the graft were evaluated with RMI. At the highest follow up functionnal result are excellent in the youngest first case (male, 22 years old) where motion and grasp are similar than the controlateral side. In the 4 others cases of mal union patients were pain free in daily activity with a functionnal wrist score of 72/100 (54–82) and a DASH of 38,3 (22,5–51,7). Only the case with the septic problem failed with pain at follow up.

Conclusion: Reconstruction of a partially destroyed articular surface by a costal graft is reliable and allows filling and resurfacing an articular cartilage void. If chondro costal graft is currently used in maxillo facial surgery it is the first report in post traumatic arthritis secondary to intra articular mal union.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 234 - 234
1 Jul 2008
LEPAGE D PARRATTE B TATU L VUILLIER F TROPET Y MONNIER G
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Purpose of the study: Spastic hypertony of the upper limb produces pronation of the forearm with flexion of the wrist and fingers. Treatment is generally based on injections of botulinum toxin and sometimes on selective neurotomy.

Material and methods: In order to achieve better selection of the motor branches innervating the muscles requires a precise knowledge of the extramuscular innervation. Similarly, for botulinum toxin, injections must be made as close as possible to zones with the greatest density of intramuscular nerve endings, considered as the zones having the greatest number of neuromuscular junctions. Knowledge of these zones is currently insufficient. We therefore conducted a macroscopic then microscopic dissection of the muscles of the ventral forearm in 30 specimens to study extra- and intra-muscular innervations and the distributions of the nerve endings.

Results: Surface maps were drawn to describe the precise localization of the motor branches for each muscle. These maps were designed as guides for surgical approaches for selective neurotomy. Then for each muscle, the zones with the greatest density of nerve endings were delimited in segments which could be used to define optimal zones of injection of botulinum toxin.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 272 - 272
1 Jul 2008
REHBY L JEUNET L BONIN N FORTERRE O TROPET Y GARBUIO P
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Purpose of the study: Locked centromedullary nailing has proven efficacy for the treament of tibial shaft fractures but its use remains controversial for the most distal fractures. The purpose of this work was to assess clinical and radiological outcome of nailing procedures used to treat fractures of the lower quarter of the leg.

Material and methods: Fifty-eight fractures of the lower quarter of the leg were treated by locked centromedul-lary nailing between 1999 and 2002. All patients were included in the analysis. Twenty-four patients aged 44 years on average (range 18–68 years) were reviewed by an independent operator at mean 43.2 months follow-up (range 18–70). Four types of nail were used, on an orthopedic table for 47 procedures and with a hanging leg for 11. The fibula was not fixed.

Results: Early complications were: compartment syndrome (n=2) and infection (n=3). Postoperative alignment was anatomic or good in 86%. Mean time to weight bearing was 66 days (range 0–180). Nonunion occurred in six patients who required revision. Secondary displacement was noted in ten patients. Knee motion was normal in all patients and ankle motion was normal in 80%. Mean time to resumed occupational activity was 5.7 months (range 1–18). At last follow-up, bone healing had been achieved in all patients.

Discussion: As compared with data in the literature, we found that locked centromedullary nailing allows early weight bearing with less risk of infection for radiological results comparable with those obtained with plate fixation. The secondary displacements resulted from defective locking of inappropriately adapted materials (holes insufficiently distal).

Conclusion: Locked centromedullary nailing is a treatment of choice for fractures of the distal quarter of the leg. Use of new nails with more distal holes should improve outcome by allowing distal locking with at least two screws in all cases.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 292 - 292
1 Jul 2008
ROCHET S OBERT L LEPAGE D VERDENET J CARDOT J MONNIER G TROPET Y GARBUIO P
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Purpose of the study: Occult fractures of the carpal bone are underestimated. An undetected fracture of the scaphoid will not be immobilized and will lead to nonunion and osteoarthritic degradation. In order to avoid late diagnosis and functional loss, in addition to lost chances and legal suites, we validated a quantitative radioscin-tigraphic (QRS) tool in a randomized prospective trial conducted from 1997 to 2003 in a routine practice setting. The series included 667 patients with wrist trauma presenting a normal plain x-ray one day 0. After day 8 these patients underwent QRS.

Material and methods: The principle of the technique consists in a classical technetium scintigraphy with two technical improvements:

quantification of uptake: uptake two-fold greater on the injured side is a sign of «certain» fracture;

software superposition of the scintigraphic image and the radiographic image used to localize the bone fracture.

Results: Forty percent of the wrist trauma patients (260/667) with a normal plain x-ray presented an occult fracture (uptake > 2 on QRS). QRS was performed on day 17.7 on average. Fractures of the scaphoid were the most frequent (42%). The uptake ratio was higher if the QRS was performed from day 11 to day 20. Statistical analysis showed that uptake ratio > 2 was independent of age, gender, bone volume, and time to QRS.

Discussion: As demonstrated by Dikson, Dias, Thomp-son and Kuckla, repeated x-ray images do not increase the rate of diagnosis of carpal bone fractures. Spitz demonstrated that scintigraphic uptake on the trauma side more than twice that on the healthy side is a sign of fracture. Garbuio, NOvert and Lepage validated QRS as a sensitive and specific diagnostic tool for occult fractures. They demonstrated that QRS is less costly, more reliable than MRI and that there are no false positives.

Conclusion: Exploration of a «bone problem» in a patient with wrist trauma must not ignore sensitive and specific tests. Ultrasonography is operator-dependent and requires validation. We thought that QRS would not resist the development of routine MRI, but observed the contrary. QRS remains the gold standard diagnostic tool for ruling out a fracture of the carpal bones.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 178 - 178
1 Mar 2006
Obert L Lepage D Clappaz P Huot D Tropet Y Garbuio P
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Aim: Treatment of unrecons tructible comminuted fractures of the radial head remains a therapeutic challenge. There is limited information on the outcome of management of these injuries with metal radial head implant. Before choosing one of them, two groups of patients were rewieved in a retrospective study comparing resection and Swanson implant.

Material and methods: 39 patients sustained unreconstructible radial head fracture between 1969 and 1992. Two groups of 24 patients were reviewed clinically and radiologically by a surgeon not involved in treatment. Functionnal outcomes of the elbow (morrey scoring – SOO scoring system, instability, cubitus valgus) and involvement of the wrist (pain, grasp, RUD instability) were evaluated with a mean follow up of 15 years (6–27,7). Elbow or wrist arthritis, ulnar variance, and evolution of Swanson implant’s were evaluated on standard Xray. 1/2 patient was a man and 1/3 cases consisted in a professional injury. Resec tion group: 16 patients with a mean age of 39 (19–65), treated with a mean preoperative delay of 29,6 days (0–150) were rewieved with a mean follow up of 18,9 years (6–27,7). There were 75% Mason type-III injuries associated with dislocation of the elbow in 18% cases. Swanson group: 8 patients with a mean age of 36 (21–57), treated with a mean preoperative delay of 4,1 days (0–15) were rewieved with a mean follow up of 12 years (8,1–20). There were 88% Mason type-III injuries with no dislocation in that group.

Results: The following criteria did not show any significant differences between both groups: Morrey scoring 77/100, SOO scoring 7,4/11, mean flexion was 130°, mean deficient extension was 18°, mean pronation 60°, mean supination 67°, grasp reached 90% of the contralateral side. Arthritis was pointed in same frequency at the elbow level (87%), and wrist level (66%) in each group. 94% of pa tients in resection group and 89% in Swanson group were satisfied. Excellent and good results are reported most frequently in Swanson group (37% resection group, 51% Swanson group). In resection group following complications were significantly more frequent: ulnar nerve irritation (2x), ulnar head dislocation (2x), ulnar head instability (3x), paraarticular ossification (5x), ulnar variance positive in all cases (mean value 3,20 mm). In the Swanson group only one implant was destroyed at the follow up.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 179 - 179
1 Mar 2006
Obert L Leclerc G D. Lepage D Clappaz P Tropet Y Garbuio P
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Aim: The purpose of the study was to evaluate the feasibility of Norian SRS bone cement injected into a distal radius following reduction and stable fixation in preventing shortening and loss of pronation-supination.

Material and methods: Between 1998 and 2000 48 patients with a mean age of 65 (54–82) sustained distal radius fracture (AO classification stage A in 26 cases, B in 15 cases, C in 7 cases) with metaphyseal comminution. Functionnal and radiological outcomes of the wrist (O’ Brien scorring, Gartland and Werley scoring, DASH) were evaluated with a mean follow up of 46 months (36–56) by a surgeon not involved in treatment. Fixation was performed in 34 cases by pins, in 14 cases by dorsal plate, in 2 cases by external fixator.

Results: 4 patient lost of follow up and 5 mal union were excluded of final evaluation. 3 RSD were pointed on the 39 evaluated patients. O’ Brien scoring reached 84/100 (54–100), Gartland and Werley scoring reached 4,6 (0–11) with 89% excellent and good results, DASH reached 23,6 (5,8–62,7). Ulnar variance changed less than 2mm between postoperative time and maximal follow up in 88%. There were no clinically adverse effects but one case of volar extrusion of injected Norian was pointed with resolutive evolution. Bone substitute was always in place at the longest follow up.

Discussion: Adams, Pogue, Mc Queen pointed the bio-mecanical and clinical advantage to fill the void secondary to the comminution to avoid the shortening of the radius. First cases reported by Kopylov and Jupiter, and prospective series of Kopylov, Sanchez Sotello and Cassidy proved the interest of an adaptative injectable cement in case of comminution. Injectable bone substitute allows to maintain the ulnar variance in competition with bone graft or bio ceramic.

Conclusion: Norian is able to fill a metaphyseal void but fixation of the fracture remains necessary.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 99 - 99
1 Apr 2005
Obert L Jarry A Elias B Candelier G Garbuio P Tropet Y
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Purpose: Pluridisciplinary therapeutic management is well defined for metastatic long bones. There are few prognostic criteria enabling an evidence-based choice between palliative surgery or abstention. We report a series of 24 metastatic femurs treated by palliative surgery and evaluated with the Tokuyashi score.

Material and methods: Sixteen women and eight men, mean age 71 years (5!-89) underwent centromedullary nailing of a metastatic femur (13/16 breast cancer in women, 20.24 other metastases. The Toskuhashi score was > 6 for 16/24 patients with pain unresponsive to morphine. Thirteen patients had fractured femurs and eleven had frail femurs due to the metastasis. Mean time to surgery was six days (1–15).

Results: A solid nail was used for four patients and a reconstruction nail for twenty. Operative time was 93 minutes (57–123). Blood loss was 200 l (150–350). There no intraoperative complications (fat embolus) excepting one tulip femur. Hospital stay was 23 days (8–55). Survival was 148 days (8–510) in patients with a frail metastatic tumour. Eight deaths occurred in patients with a fractured metastatic tumour (six within the first three postoperative weeks), two after preventive nailing. Weight bearing in living patients with a fractured femur was possible at 57 days (30–90). Only six patients required morphine in the early postoperative period. For the femurs with an isolated metastasis, the antalgesic effect of centromedullary nailing was significant (p< 0.05). There was a significant correlation between thee Tokuyashi score and mean survival. Mean survival in patients with a score < 3 was 2.1 months. Mean survival in patients with a score > 6 was 17 months.

Conclusion: Centromedullary nailing of the femur for metastatic fracture or fragilisation remains the treatment of choice for patients with short life expectancy. This technique limits pain while preserving independence as long as possible. The Tokuyashi score is correlated with patient survival. If this easy to establish score is too low (< 3), the survival can be expected to be insufficient for any surgical benefit.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 131 - 131
1 Apr 2005
Lepage D Obert L Givry F Clappaz P Garbuio P Tropet Y
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Purpose: We report our experience with costal osteochondral autografts of the scaphoid for the treatment of radioscaphoid osteoarthritis complicating chronic scapholunate non-union or dissociation.

Material and methods: The technique was used for nine patients from 1994 to 2001 (eight men and one woman, mean age 45 years, age range 26–62). The proximal two-thirds of the scaphoid were resected. An osteocartilaginous graft was harvested from the ninth rib and after remodelling to the scaphoid cavity was fixed to the base of the scaphoid with a Kirshner wire.

Results: Mean follow-up was 2.5 years. Pain improved significantly in all patients. Force was 80% on average compared with the healthy side. Mean wrist motion in flexion and extension was 91° (70–150°).

Conclusion: This technique has provided encouraging preliminary results in terms of restored force and wrist motion. It is an interesting alternative to conventional techniques.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 49
1 Mar 2002
Obert L Grelet V Jeunet L Polette A Tropet Y Garuio P
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Purpose: Fractures o the distal radius remain a problem difficult to resolve. A post-operative displacement is observed in about half the cases. The displacement is generally a secondary shortening with mis- or unrecognized metaphyseal comminution. In the United State, autologous bone graft is widely used, which, like bone substitutes also used in France, allows appropriate filling of the metaphyseal comminution which always remains open after pin withdrawal. We present a prospective series of 30 patients with a fracture of the distal radius treated by pin or plate fixation in combination with Norian to fill the substance loss subsequent to metaphyseal comminution.

Material and methods: Thirty patients were treated between November 1998 and March 1999 for fracture of the distal radius with posterior displacement. The inclusion criterion was comminution > 2 according to the Laulan classification. All were treated by osteosynthesis with plate or pin fixation and insertion of Norian. There were 26 women and 4 men. Twenty-two patients had an articular fracture. Plate fixation was used in ten patients and pin fixation in 19.

The fracture involved the dominant side in 21 cases. The fracture was closed in all cases. Norian was injected after osteosynthesis following the recommendations of the manufacturer (impaction of the cavity rims created by the comminution, no motion for 10 min after injection). All patients were reviewed at 1, 3 and 6 months and at last follow-up. The flexion-extension and pronation-supination amplitudes were measured, as was the muscle force.

Results: All patients were reviewed with a minimum follow-up of at least 2 years. Mean age was 65 years (545–82). All fractures had consolidated. There were three defective calluses in patients aged over 80 years with osteoporosis; the clinical outcome was better than the radiological image. Three patients developed reflex dystrophy. Mean amplitudes were: flexion 43.6°, extension 52.3°, pronation 63°, supination 70°. The mean wrist force was 52 kpa. No complications related to Norian were observed. Two biopsies were made and showed, in one case at six months, early signs of osteointegration. The product disappeared progressively after 2 years but not in all patients. The immediate postoperative ulnar variance was unchanged at last follow-up. In seven patients the ulnar variance was modified with impaction of the fracture line but with no effect on pronation-supination.

Discussion: Metaphyseal comminution after fracture of the distal radius is a classical observation. It may be located posteriorly or anteriorly and leads to secondary impaction before or after pin withdrawal. To avoid this problem, and the inversion of the ulnar variance, the bone defect must be filed at the initial surgical procedure. Solutions include bone grafts (autograft, allograft, xenograft) and injection of methylmethacrylate. Bone substitutes can now be used to fill the gap without the theoretical or real risk of bacterial contamination. The first studies in animal models were published in 1995. Kopylov and Jupiter demonstrated the contribution of Norian for fractures of the lower end of the radius to avoid impaction and improve pronation-supination.

Conclusion: Metaphyseal comminution of fractures of the distal radius is a real problem. If the gap is not filled during the initial surgical treatment, impaction with inversion of the ulnar variance can lead to pronation-supination insufficiency. Norian SRS can be used to fill the bone defect producing mechanical results as good as or better than compression cancellous grafts. The produce is resorbed slowly and is easy to use. Its high cost is undoubtedly an inconvenience limiting its use to “young” patients with fractures of the distal radius. After 70 years, the absence of a strong correlation between the radiological and clinical result suggests a less “aggressive” therapeutic approach.