Introduction

Uncemented components necessitate accurate intraoperative assessment of size to avoid complications such as calcar fracture and subsidence whilst maintaining bone stock on the acetabular side. Potential problems can be anticipated pre-operatively with the use of a templating system. We proposed that pre-operative digital templating could accurately assess femoral and acetabular component size.

Introduction: Quadriceps femoris (QF) atrophy has been associated with the development of knee OA and is a major cause of functional limitations in affected individuals. TKA reliably reduces pain but improvements in function are less predictable and deficits may persist for up to 2 years post-operatively. Patients undergoing elective surgery are routinely optimized medically but we hypothesized that pre-operative strength and fitness improvements would also enhance outcome.

Objectives: To determine the effect of a 6 week lower limb strengthening programme on post-operative QF strength and CSA, pain and functional scores.

To determine changes in Myosin Heavy Chain (MHC) isoform, hypertrophy marker IGF-1 and atrophy markers MuRF-1 and MAFbx.

Methods: 20 volunteers currently awaiting TKA were randomly assigned to a control [C] or intervention [I] group. [I] completed a 6 week home based, supervised exercise programme. Post-operatively all patients completed a standard inpatient physiotherapy routine.

Assessments were completed at baseline (T=0), T=6 weeks (just prior to operation) and 3 months post-operatively (T=18 weeks). Assessments included isokinetic dynamometry; MRI QF CSA and American Knee Society scores. A percutaneous muscle biopsy of the vastus lateralis muscle was also performed at T=0 and T=6 under local anaesthesia.

Results: At baseline there were no significant differences in parameters between groups. At T=18, [I] showed an 86% difference in QF peak torque above controls (P=0.003). CSA also improved by 6% versus a drop of 2.5% in [C] (P=0.041). Both groups showed improvements in Knee society function scores but [I] improved by 13 points more than [C] (P=0.044).

MHC IIa mRNA expression increased by 40% whilst IIx decreased by 60% representing a shift to a less fatigable fibre type (P=0.05 and 0.028 respectively). IGF-1, MuRF-1 and MAFbx mRNA levels did not change significantly in either group.

Conclusion: To our knowledge we have documented for the first time post-operative benefits by using a pre-operative training programme in TKA. This was manifest by continued rise in quadriceps peak torque, CSA and improved Knee society functional scores. We have also demonstrated the preservation of muscle plasticity in knee OA and suggest that factors other than known hypertrophy and atrophy pathways may be responsible.

Introduction: After total knee arthroplasty (TKA) patients develop marked asymmetrical quadriceps femoris (QFM) weakness due to neurological activation deficits and muscle atrophy; this is associated with a slow (type I) to fast (type II) shift in myosin heavy chain (MHC) expression. Preoperative resistance training (prehabilitation) has been shown to improve strength and function after TKA however is considered costly and labour intensive. Neuromuscular electrical stimulation (NMES) offers the potential for unsupervised training, although its role in prehabilitation has not been investigated.

Aims: Determine changes in myosin heavy chain (MHC) mRNA expression following preoperative NMES.

Evaluate the ability of NMES prehabilitation to improve strength and functional recovery post-TKA.

Methods: Randomised control efficacy study applying NMES to the affected QFM for 20 min, 5 days/week, for 8 weeks pre-TKA. Isometric QFM strength was determined dynametrically and muscle cross-sectional area (CSA) calculated from MRI axial images. Function was assessed with a walk test, stair-climb test, and chair-rise test. Real-time PCR analysed MHC mRNA expression. All evaluations were performed at baseline and preoperatively with strength, CSA and function also tested at 6 and 12 weeks post-TKA.

Results: Patients scheduled for TKA were recruited and randomised into control (n=9) or NMES (n=5) groups. Only the NMES group increased strength (27.8%; p=0.05) and CSA (7.4%; p=0.013) preoperatively. MHC type II mRNA decreased by 42% (p=0.078) indicating a fast to slow fibre shift. Function also improved in the NMES group (stair climb [p=0.006]; chair rise [p=0.018]). While all patients deteriorated after surgery, only the NMES group had notable strength gain from 6 to 12 weeks (53%; p=0.011) with associated functional recovery (stair-climb, p=0.017; chair-rise, p=0.01; walking speed, p=0.014). There were differences seen between the groups at 3 months post-TKA: stair climb (61.6%, p=0.04) and chair rise (28.4%, p=0.013). There was greater muscle atrophy seen in the controls than the NMES group post-TKA when compared to baseline (12.1% [p=0.034] versus 3.7% [ns]).

Conclusions: This study has shown that 8 weeks preoperative quadriceps strengthening using home-based NMES can safely and effectively attenuate the extent and duration of QFM weakness and atrophy after primary TKA. This translates into significantly faster functional recovery thereby expediting a return to normal activities.

Introduction: The pilon fracture extending from the distal tibial metaphysis into the ankle joint represents one of the most challenging injuries faced by orthopaedic surgeons. Achieving the ideal of anatomic reduction and stable fixation is often impeded by the frequently severe soft tissue injuries associated with these fractures. In June 2004 we began treating intra-articular pilon fractures by minimally invasive techniques.

Methods: The minimally invasive technique used involves reduction of the fracture by ligamentotaxis with the use of the traction table and manipulation of the foot to correct rotation, varus/valgus, pro/recurvatum. Any further reduction where necessary was performed using an ankle arthroscope and a probe introduced through stab incisions anteriorly. Following reduction a distal tibial locking plate was applied percutaneously to the medial of the tibia. Locking screws were then inserted percutaneously. All significant anterior or posterior distal tibial fragment were fixed separately with an anterior percutaneously inserted interfragmentary compression screw.

We compared all cases of closed intra-articluar fractures (AO types C2 and C3) fixed by the method described above in a one year period (June 2004 – June 2005) – Group 1 (n = 26), with the immediate previous one year period (June 2003 – June 2004) of matched closed fracture pattern fixed by formal open reduction and internal fixation – Group 2 (n = 16).

Mean follow up was 26 months. All bony and soft tissue complications were recorded. A specific assessment of foot and ankle outcome was undertaken using the American Orthopaedic Foot and Ankle Score (AOFAS). Scoring was undertaken on two separate occasions at a mean of 9 and 24 months post operatively, by orthopaedic surgeons blinded to the treatment modality. The mean of the two scores was then recorded. It has been previously demonstrated that the functional outcome in pilon fractures improves for approximately 2 years after injury.

Results: We observed a much higher incidence of complications in the open reduction group when compared with the minimally invasive group. An excellent AOFAS result was obtained in 83% (20/24) of the patients in the minimally invasive group, the same result was achieved in only 12.5% of the formal open reduction and fixation group.

Conclusion – The use of the minimally invasive reduction method described here in combination with the insertion of percutaneous fixation, in the form a medial locking plate with or without additional percutaneously inserted antero-posterior screws represents a valuable method of treating the most complex of closed pilon fractures.

Introduction: K wiring is a popular technique to help maintain anatomic reduction of distal radial fractures. It has the advantage of being a semi-closed procedure, which is simple to perform. Complications related to K wires include infection, migration and damage to tendons and nerves.

We aimed to perform a randomized prospective study to determine the outcome of Buried versus Exposed K wire placement.

Methods: We prospectively recruited 60 consecutive patients with displaced distal radius fractures requiring K wiring to our study. They were randomized to Buried versus Exposed K wire groups.

Patient details were collected and follow up was performed at 2 and 6 weeks post op.

Infection at pin sites was measured on a 0 to 6 point scale. Superficial radial nerve was assessed with light touch and 2 point discrimination. EPL tendon was also assessed for damage.

Results: 60 consecutive patients were recruited to the study and randomized to buried or exposed k wires. There were 30 patients in each group.

No damage to EPL tendon was recorded in either group at 6/52 follow up.

There was a slight increased rate of superficial infection at exposed pin sites noted at 2/52 follow up however this was not seen at the 6/52 follow up. Superficial radial nerve damage was noted in one case only. This was in the buried k wire group and occurred following removal of the radial wire.

Conclusion: There appears to be slight increased risk of superficial pin site infection in the exposed k wire group at 2/52 but this is not seen at 6/52 follow up. Buried k wires require a second procedure to remove the wires and this runs the risk of superficial radial nerve damage.

Thus it would appear that leaving k wires exposed is the safer and more convenient method of K wiring the displaced distal radius fracture.

Introduction: Fasting overnight NPO (Nulla per os) has been routine before surgery for the past century. The practice was previously designed to reduce the risk of pulmonary aspiration on induction. However this practice has been challenged over the recent years and is changing anaesthetic practices are now more liberal. There are many new concepts aimed at improving patient outcome by regulating metabolic, endocrine, inflammatory and immune responses. This combined with better patient satisfaction and lower anxiety has led to research in this area.

Overnight fasting can induce post operative insulin resistance. Insulin resistance is related to infectious morbidity and increased hospital length of stay (HLOS). Previously this concept was only important in diabetic patients. Surgery places the body under metabolic stress and even a short period of fasting will change the metabolic state of the patient. Indeed physical trauma can cause a triad known as the “diabetes of injury”: insulin resistance, hyperglycaemia and glucose intolerance. Preparation for surgery by maintaining a fasted state and catabolic metabolism may have deleterious consequences for the patient.

Previous studies on elective patients has shown that pre operative carbohydrate loading can reduce insulin resistance and mitigate the inflammatory response by immunomodulation. It has not previously been shown to have an effect in the hip fracture population. This particular group of patients are often elderly and require medical and anaesthetic work up. This delay can mean that the patient is kept fasting for prolonged periods and often overnight.

Methods: With full ethical approval at Connolly Hospital we prospectively randomised all femoral and hip fractures for surgery. We excluded diabetics and pregnant women from the study. A high carbohydrate drink called Nutritia Pre Op was selected. Random serum glucose was taken on admission. Patients were randomised and selected for the trial by hidden ballot. Anaesthetic approval was sought for each case. We compared our standard treatment for hip and femoral fractures of strict NPO prior to surgery versus giving patients the Pre Op drink. Each carton was 200ml and up to 4 were given the night before surgery. In the morning the patients were given another 2 drinks. There was a strict minimum 2 hour NPO period before leaving the ward. Glucose levels were then taken at 1 and 12 hours post operatively to assess whether hyperglycaemia was present. As per laboratory values a normoglycaemia was considered as 4–6mmol/l. Gender, age, type of operation, HLOS, complications and re-admissions were noted.

Results: In total 17 patients were enrolled in the study. Group A had 9 patients and were kept NPO as the control group. Group B had 8 patients enlisted in the Pre Op Drink group. In group A, 6 of 9 (67%) patients had a post operative hyperglycaemia. Average age in group A was 79.6 years with an average HLOS of 15.8 days. 4 patients between them required 8 readmissions over a 3 month post operative period. Group B showed 2 out of 8 (25%) patients had a hyperglycaemia. They had an average age of 69 years with an average HLOS of 11.75 days. 4 patients required 4 readmissions.

Conclusions: Pre Op high carbohydrate drinks significantly decrease post operative hyperglycaemia as per the laboratory ranges. This in turn supports that it decrease insulin resistance by preparing the body for surgery in a fed state. In the same way that one would not prepare for a marathon by fasting 24 hours before hand so the body recognizes that the surgical stress is not best dealt with when in a fasted state. The control group had twice as many readmissions and a longer HLOS. Previous studies show that there is decreased anxiety, thirst and hunger both pre and post operatively. We have shown that this is a safe drink to give and that post operative hyperglycaemia was better controlled.

Introduction: Quadriceps femoris muscle (QFM) weakness has been associated with the development and progression of knee osteoarthritis, primarily due to arthrogenic muscle inhibition. Neuromuscular electrical stimulation (NMES) devices cause muscle contraction by circumventing these neural inhibitory feedback pathways. While it has been proposed this occurs in a reversed pattern of muscle fibre recruitment, the molecular mechanisms have not been clearly elucidated.

Methods: This randomised control efficacy study applied NMES to the affected QFM for 20 min, 5 days a week, for 8 weeks. Strength was assessed dynometrically and function determined using validated measures (timed stair climb, chair rise and 25 metre walk tests). A quantitative polymerase chain reaction (PCR) method measured quantities of types I, IIa, and IIx myosin heavy chain (MHC) mRNA of muscle specimens taken from vastus lateralis of the affected QFM. Expression of genetic markers associated with muscle wasting (MAFbx and MURF-1; E3 muscle specific ligases of the ubiquitin proteasome pathway) and muscle anabolic states (IGF-1) were also determined. Statistical analysis was performed using ANOVA’s and independent t-test’s where appropriate.

Results: Sixteen patients (10 women and 6 men) with radiologically severe knee OA were recruited and randomised into a control (n=6) or intervention (n=10) group. Groups were similar in terms of age (64.8 ± 11.0 vs. 64.6 ± 7.6; mean ± SD) and BMI (31.8 ± 6.1 vs.30.7 ± 2.9). There were significant improvements in function (stair climb [p< 0.01]; chair rise [p< 0.01]) and QFM strength (isokinetic [p< 0.01]; isometric [p< 0.01]) in the NMES group at week 8 compared to week 0. At the genetic level, IGF1 expression significantly increased two-fold in the NMES group (p< 0.05); Despite a 17% decrease in MAFbx expression, neither it nor MURF-1 changed significantly. MHC-I and MHC-IIa mRNA expression did not change in either group; MHC-IIx decreased by 42% in the NMES group only but was not statistically significant.

Conclusions: The use of an 8 week NMES program produces significant quadriceps strength gain with associated functional improvements in subjects with severe knee OA. Expression of muscle atrophy markers did not change significantly; however increased IGF-1 expression could potentially inhibit further muscle atrophy. Of the 3 MHC mRNA isoforms, only MHC-IIx demonstrated a change in response to NMES. These results would indicate NMES induces early quadriceps strength gain by a predominantly neurological adaptation.

Quadriceps femoris muscle (QFM) weakness is associated with the development of knee osteoarthritis (OA). Neuromusclar electrical stimulation (NMES) circumvents neural inhibition causing muscle contraction, however there is little reported data demonstrating its role in knee OA. Our aim was to evaluate the effectiveness of a NMES program in patients with knee OA.

Sixteen patients (10 women, 6 men) with severe knee OA were randomised into control (n=6) or intervention (n=10) groups. These were similar in terms of age (64.8 ± 11.0 vs. 64.6 ± 7.6; mean ± SD) and BMI (31.8 ± 6.11 vs.30.7 ± 2.9). NMES was applied using a garment-based stimulator for 20 min/day, 5 d/wk for 8 weeks. Isokinetic and isometric QFM strength were determined at baseline, and weeks 2, 5, and 8 using a dynomometer. Functional assessments involved a 25 metre timed walk test (TWT), timed stair-climb test (SCT), and timed chair-rise test (CRT) at baseline and week 8. Subjects recorded NMES session duration in a log book while the device also recorded total treatment time.

Function significantly improved in the NMES group as determined by the timed SCT (p< 0.01) and the timed CRT (p< 0.01) at week 8 compared to week 0. Isometric QFM strength was significantly higher in the NMES group at weeks 2, 5 and 8 than week 0. Compared to week 0, isokinetic hamstring strength increased significantly in the NMES group at week 2, week 5 and week 8 while isokinetic QFM strength increased at week 5 (p< 0.05) and week 8 (p< 0.01). Patient recorded compliance was 99.5% (range, 97.1%–100%) and overall usage recorded on the stimulator was 96.1% ± 13.2.

The use of a portable home-based NMES program produced significant QFM strength gain with associated improvement in function in patients with severe knee OA. Compliance was excellent overall.

Background: Quadriceps femoris muscle (QFM) weakness has been implicated in the development of knee osteoarthritis (OA) as well as predicting functional ability after TKA. Preoperative strengthening (prehabilitation) may be facilitated by applying neuromuscular electrical stimulation (NMES) to the affected QFM using a garment-based portable stimulator.

Methods: Single blind, randomised control efficacy study with NMES applied to the affected QFM for 20 min, 5 days a week, for 8 weeks pre-TKA. Isokinetic and isometric strength was assessed at baseline, week 2, week 5 and immediately pre-op. Function was assessed using a 25 metre timed walk test (TWT), timed stair-climb test (SCT), and timed chair-rise test (CRT) at baseline and pre-op.

Results: 13 patients (8 women and 5 men) scheduled for TKA for knee OA were recruited and randomised into a control (n=5) or intervention (n=8) group. Groups were similar in terms of age (65.5 ± 6.8 vs. 61.8 ± 9.0; mean ± SD) and BMI (29.7 ± 2.1 vs.33.2 ± 5.6). There was an improvement in SCT (p< 0.01) and CRT (p< 0.01) in the NMES group at week 8 compared to week 0. Isokinetic hamstring strength and isometric QFM strength increased significantly at weeks 2, 5 and 8 compared to baseline whereas isokinetic QFM strength only increased at week 5 (p< 0.05) and week 8 (p< 0.01) compared to baseline.

Conclusion: The use of a portable home-based NMES program for 8 weeks results in significant strength gains with associated improvements in function in patients scheduled for TKA for knee OA.

Introduction: It is standard procedure in our unit to use compartment pressure monitoring in all patients presenting with tibial fractures. A sustained difference of less than 30mmhg between the diastolic blood pressure and the compartment pressure (known as the delta pressure) is taken as an indication for fasciotomy.

Aim: To review the impact continuous compartment pressure monitoring has on the management of patients with tibial fractures.

Methods and materials: Between January 2004 and June 2006, 28 patients admitted to our unit following tibial fracture had a compartment pressure monitor inserted. The outer sheath from a 16G cannula connected to an arterial manometer was used in each case.

The records of these 28 patients were reviewed. Twenty three were male. Ages ranged from 19 to 83 years old. Eight patients had open fractures and 20 had closed fractures. Seven patients (25%) had difficulties with communication which could have impeded or delayed the diagnosis of a compartment syndrome.

Results: Average delta pressure ranged from nine to 69mmHg in our patient population. High energy injuries resulted in a significantly lower delta pressure (p=0.05). Open fractures were more likely to result from high energy, although this was not statistically significant (p=0.068). Two patients had fasciotomy performed based on clinical picture and a sustained decrease in delta pressure. No patient had a missed compartment syndrome.

Conclusion: Continuous compartment pressure monitoring is especially useful in patients who are most at risk for compartment syndrome i.e. those having sustained high energy injury or open fractures. It can also aid decision making when the clinical picture of compartment syndrome is equivocal, or when a patient’s ability to communicate pain is impaired.

However, due to the ease of use and the low cost involved, we recommend that all patients with tibial fracture should have continuous compartment pressure monitoring performed.

Introduction: In the United Kingdom, the wait for hip or knee joint replacement surgery can be particularly long. There are conflicting research accounts whether debilitating symptoms, such as pain and the effects on physical function and quality of life deteriorate or remain the same in individuals who are on the waiting list for hip or knee joint replacement. This study was conducted to investigate the severity of pain, level of physical function and quality of life amongst adults with osteoarthritis awaiting hip or knee joint replacement.

Methods: A longitudinal study was undertaken in the North West of England during 2003–2005. A total of 105 patients listed for primary hip or knee joint replacement were recruited, interviewed at baseline, and followed-up at three, six and nine months, or until their joint replacement. Measurement tools used were a visual analogue scale (VAS), Western Ontario McMaster’s University (WOMAC) Osteoarthritis Index and the Medical Outcomes Study Short Form Health Survey (SF-36).

Results: High levels of pain and poor physical function and quality of life were experienced by patients on the waiting list for joint replacement. At the three month follow-up (n=84) changes in VAS pain scores (0.6; 95% CIs mean difference 0.3,1.0); WOMAC pain scores (1.2 (95% CIs mean difference 0.7, 1.8) and WOMAC physical function scores (4.8; 95% CIs mean difference 2.8, 6.7) were significantly worse compared to baseline. However, there were minimal changes in quality of life as measured by the SF-36 while on the waiting list.

Discussion: The often long wait for joint replacement surgery and deterioration in pain and physical function has highlighted the need for active management by health professionals while patients are on the waiting list. There needs to be a clinical reassessment of patients by health professionals while on the waiting list for joint replacement.